id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314019-8n0jafsk	Feng, Qian	Induction and suppression of innate antiviral responses by picornaviruses	2014-07-18		.txt	text/plain	7215	358	43	We focus on two important and well-studied genera of picornaviruses, namely Enterovirus and Cardiovirus, and discuss how their RNAs are recognized by RLRs, and how they antagonize the IFN-a/b induction pathway and SG formation in infected cells. Picornavirus infections activate a cytosolic RNA sensor, MDA5, which in turn, induces a type I interferon response, a crucial component of antiviral immunity. Picornavirus infections activate a cytosolic RNA sensor, MDA5, which in turn, induces a type I interferon response, a crucial component of antiviral immunity. However, it is important to point out that the caspase-and proteasome-mediated MDA5 cleavage events were observed under conditions where MDA5 expression level was artificially upregulated prior to infection (either by poly(I:C) or viral RNA transfections) [39, 42] , which may sensitize cells for virus-induced apoptosis, thereby promote caspase-and proteasome-mediated protein degradations.	./cache/cord-314019-8n0jafsk.txt	./txt/cord-314019-8n0jafsk.txt