id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312392-8zxl48af	Buonavoglia, Canio	Canine Coronavirus Highly Pathogenic for Dogs	2006-03-17		.txt	text/plain	1169	67	53	We report an outbreak of fatal disease in puppies caused by a pathogenic variant of CCoV that was isolated from organs with severe lesions. NSP 3b (22 aa) was 49 aa shorter than expected because of a 38-nucleotide deletion and a frame shift mutation in the downstream sequence that introduced To confirm the pathogenic potential of strain CB/05, we experimentally infected two 6-month-old dogs (authorization no. Experimental infection of dogs with the virus isolate resulted in a severe systemic disease that mimicked the clinical symptoms observed in the outbreak. Epidemiologic studies are required to determine whether the pantropic CCoV strain is a new coronavirus variant emerging in canine populations or a widespread infectious agent of dogs that usually goes undetected. Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease Genotype-specific fluorogenic RT-PCR assays for the detection and quantitation of canine coronavirus type I and type II RNA in faecal samples of dogs	./cache/cord-312392-8zxl48af.txt	./txt/cord-312392-8zxl48af.txt