id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303319-v3iyur78	Abe, Takayuki	Cytosolic DNA‐sensing immune response and viral infection	2019-02-26		.txt	text/plain	7788	355	38	The findings of these studies have suggested that antiviral responses are mediated by cytosolic or intracellular compartment sensors and their adaptor molecules (e.g., TLR, myeloid differentiation primary response 88, retinoic acid inducible gene‐I, IFN‐β promoter stimulator‐1, cyclic GMP‐AMP synthase and stimulator of IFN genes axis) for the primary sensing of virus‐derived nucleic acids, leading to production of type I IFNs, pro‐inflammatory cytokines and chemokines by the host cells. Thus far, many different immune evasion strategies employed by various viruses have been identified, including: (i) interference with the functions of the host innate immune response via physical interactions with viral antagonistic proteins targeted to sensors, adaptors, related intracellular kinases and transcription factors; (ii) inducing degradation or specific cleavage at the protein level; and (iii) sequestration of signal transduction molecules targeting the PTM systems.	./cache/cord-303319-v3iyur78.txt	./txt/cord-303319-v3iyur78.txt