id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299747-qovrstak	Deval, Jerome	Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus	2014-09-17		.txt	text/plain	4336	247	45	title: Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus Jerome Deval, Julian A Symons and Leo Beigelman A number of important human infections are caused by positive-strand RNA viruses, yet almost none can be treated with small molecule antiviral therapeutics. The initial major class of nucleoside analogs of therapeutic potential to demonstrate potent inhibition of HCV RNA polymerase activity were 2 0 C-methyl-ribonucleosides, The first 2 0 C-methyl ribonucleosides were originally synthesized in the 1960s [18] . 0 -azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture	./cache/cord-299747-qovrstak.txt	./txt/cord-299747-qovrstak.txt