id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-298779-0mjizsoo	Narendrula, Rashmi	RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines	2016-02-24		.txt	text/plain	7172	364	49	The abnormal RNA disruption bands that occur upon chemotherapy drug exposure are smaller in molecular weight than the 28S and/or 18S rRNAs. To determine whether the abnormal bands originate from the 28S and/or 18S rRNAs, Northern blotting experiments were performed on total RNA prepared from A2780 cells after incubation in the absence or presence of docetaxel for up to 48 h (Fig. 4) . Previous studies have shown that a variety of apoptosisinducing agents with distinct mechanisms of action (glucocorticoids, okadaic acid, tumor necrosis factor (TNF), dexamethasone, a calcium ionophore and a tricothecene mycotoxin) were able to induce an ordered, apoptosis-associated rRNA degradation in several different cell types, including plant cells and the unicellular organism yeast [11-13, 15-17, 24] . However, this study is the first to report the ability of structurally distinct cytotoxic chemotherapy agents with different mechanisms of action to induce the formation of high molecular weight rRNA degradation fragments (Figs.	./cache/cord-298779-0mjizsoo.txt	./txt/cord-298779-0mjizsoo.txt