id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295019-8tf8ah6g	Weber, Wilfried	Emerging biomedical applications of synthetic biology	2011-11-29		.txt	text/plain	9511	475	36	Synthetic mammalian transcription circuits consisting of a chimeric small-molecule-responsive transcription factor and a cognate synthetic promoter were originally designed for future gene-based therapies, and the aim was to adjust therapeutic transgene expression in mammalian cells in response to a pharmacologically active substance 34, 47, 49, 91 . When mammalian cells that are transgenic for the screening circuit are exposed to a compound library, they detect and modulate reporter gene expression in the presence of a non-toxic, cellpermeable and bioavailable molecule that has a classspecific core structure and corresponding drug activity (for example, antibiotic activity) (FIG. The availability of compact RNA sensor-actuators that are easy to design and to alter and that control transgene expression in response to intracellular levels of key proteins may also improve the ability to link metabolic disease states with gene-based therapeutic interventions.	./cache/cord-295019-8tf8ah6g.txt	./txt/cord-295019-8tf8ah6g.txt