id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293163-udcw1mx5	Lu, Patrick Y.	Modulation of angiogenesis with siRNA inhibitors for novel therapeutics	2005-02-04		.txt	text/plain	6378	329	34	The functional validation of angiogenic factors for their specific role has been greatly facilitated by the use of RNAi inhibitors, revealing a network involving the early activation of the VEGF pathway and interactions among MMPs and adhesion molecules, leading to the regulation of signal transduction pathways. MMP9 and MMP2 are important for the mobilization of sequestered VEGF and initiation of tumor angiogenesis [17] , whereas specific integrins mediate interactions between endothelial cells and the BM by activating the integrin receptor signaling that controls many key functions, such as proliferation [18] . The involvement, revealed by siRNA, of diacylglycerol kinase a (Dgka) in hepatocyte growth factor (HGF)-stimulated cell migration, which impaired angiogenesis in vitro, indicated its essential role in both proliferative and migratory response to VEGF, and suggested that it is a novel therapeutic target for controlling angiogenesis [43] .	./cache/cord-293163-udcw1mx5.txt	./txt/cord-293163-udcw1mx5.txt