id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289038-15yp9uqy	Chow, Jonathan Tak-Sum	Prediction and Analysis of SARS-CoV-2-Targeting MicroRNA in Human Lung Epithelium	2020-08-26		.txt	text/plain	5312	445	62	The purpose of this study was to identify microRNA with predicted binding sites in the SARS-CoV-2 genome, compare these to their microRNA expression profiles in lung epithelial tissue and make inference towards possible roles for microRNA in mitigating coronavirus infection. Another recent study used a high-throughput reporter screen of miRNA from human and mouse respiratory epithelial cells to identify hsa-miR-127-3p, hsa-miR-486-5p, and hsa-miR-593-5p as contributors to the antiviral defence against influenza A virus by targeting the genomes of the H3N2 and attenuated PR8 (H1N1) viral strains [16] . Given the wealth of evidence supporting a role for miRNA in host cell antiviral defence mechanisms, we sought to identify human miRNA that have the potential to target the SARS-CoV-2 genome. DEA of Calu3 cells infected with SARS-CoV revealed that only hsa-miR-155-3p (upregulated) and hsa-let-7a-3p (downregulated) out of the 128 miRNA we identified in this study, were differentially expressed ( Figure 4B ).	./cache/cord-289038-15yp9uqy.txt	./txt/cord-289038-15yp9uqy.txt