id author title date pages extension mime words sentences flesch summary cache txt cord-287153-jbuuph6w Lund, Morten Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) 2016-10-21 .txt text/plain 7435 399 54 The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus (SAV). The SAV RNA level in heart was significantly lower in the co-infected fish at 4 and 6 WPC-SAV compared to the SAV3 controls (p < 0.05). Using a non-parametric rank test of the ordinal histopathological score, changes in pancreas were found to be significantly lower at 4 and 6 WPC-SAV in both early and late co-infection compared to the SAV control groups (p < 0.05), except at 4 WPC-SAV in the PRV-SAV3-late group (Figures 6 and 7) . Microarray analysis was performed on hearts sampled at 4 and 6 WPC-SAV from the late co-infection and differences between the SAV3 control and PRV-SAV3-late group were analyzed (Table 2) . SAV RNA levels in heart were significantly lower 6 WPC-SAV in the early co-infected groups compared to the SAV controls. ./cache/cord-287153-jbuuph6w.txt ./txt/cord-287153-jbuuph6w.txt