id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283346-0v4b6do2	Ansari, Abdul Wahid	Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1 (HIV-1)-infected individuals	2006-08-17		.txt	text/plain	4326	220	48	CCL2 was the most strongly regulated gene at mRNA level and its serum concentration was significantly elevated in viremic compared with aviremic and HIV-1 seronegative controls, indicating a positive correlation between viremia and CCL2. For example, the C-C chemokines macrophage inflammatory protein (MIP)-1a/CCL3, MIP-1b/CCL4 and regulated upon activation, normal T cell expressed and secreted (RANTES)/ CCL5 inhibit M-tropic HIV-1 infection by competing with the virus for its binding to the co-receptor CCR5 (11) (12) (13) (14) (15) (16) (17) . To investigate the impact of HIV-1 viremia on the host inflammatory cytokine/chemokine network, more specifically on CCL2, we utilized DNA microarray approach on PBMC RNA derived from HIV-1-infected viremic and aviremic individuals. In this study, we report that HIV-1 viremic patients show an altered expression of key inflammatory cytokines and chemokines as compared with aviremic individuals. Furthermore, increased mRNA transcripts were again detected in CCL2, CXCL10 and IFN-c when more RNA samples derived from additional aviremic and viremic patients were analyzed individually.	./cache/cord-283346-0v4b6do2.txt	./txt/cord-283346-0v4b6do2.txt