id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-281020-g1muealp	Belov, George A	(+)RNA viruses rewire cellular pathways to build replication organelles	2012-10-01		.txt	text/plain	3965	202	30	The universal requirement of (+)RNA viruses for cellular membranes for genome replication, and the formation of membranous replication organelles with similar architecture, suggest that they target essential control mechanisms of membrane metabolism conserved among eukaryotes. These viruses universally require cellular membranes for assembly of their replication complexescontaining viral proteins, RNA, and host factorsto amplify their genome. Expression of poliovirus and HCV proteins in the presence of BFA resulted in the appearance of new membrane structures that are indistinguishable from those observed without the drug, indicating that GBF1 is more probably involved in the function of replication organelles than in their formation [41, 45] . For HCV, the absence of PI4KIIIa activity induced a dramatic change in the ultrastructural morphology of the membranous replication complex, suggesting a role of PI4P in recruiting specific membrane-shaping proteins [51 ] .	./cache/cord-281020-g1muealp.txt	./txt/cord-281020-g1muealp.txt