id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267027-diwm1940	Le, Shu-Yun	Conserved tertiary structure elements in the 5′ untranslated region of human enteroviruses and rhinoviruses	1992-12-31		.txt	text/plain	4348	270	59	Abstract A combination of comparative sequence analysis and thermodynamic methods reveals the conservation of tertiary structure elements in the 5′ untranslated region (UTR) of human enteroviruses and rhinoviruses. Base pairings between highly conserved 17-nucleotide (nt) and 21-nt sequences in the 5′ UTR of human enteroviruses and rhinoviruses constitute a predicted pseudoknot that is significantly more stable than those that can be formed from a large set of randomly shuffled sequences. The predicted pseudoknots, K2 (tertiary interactions: between the region 497-501 and 550-554) and K3 (579-581 and 600-602) in the RLP of PV2L were found to be totally conserved in all 22 human enteroviruses and rhinoviruses. Based on the common RNA secondary structures (Le and Zuker, 1990 ) of the 5' UTR in 18 human enteroviruses and rhinoviruses, two sequences complementary to the highly conserved polypyrimidine sequence in all picornaviruses were identified in human 18 S rRNA .	./cache/cord-267027-diwm1940.txt	./txt/cord-267027-diwm1940.txt