id author title date pages extension mime words sentences flesch summary cache txt cord-264678-wt0lvhfl Wu, Tzong-Yuan IRSS: a web-based tool for automatic layout and analysis of IRES secondary structure prediction and searching system in silico 2009-05-27 .txt text/plain 5333 306 58 To develop the IRES search system, it will be necessary to screen the database of virus sequences by the prediction of secondary structure to identify the candidate IRES element in the virus genome, especially those positive strand viruses with 5' untranslated regions. Enterovirus IRES domain IV [25] , was first selected as a target to compare with the whole genome sequences from four different viruses (Enterovirus 71 (U22521), Bovine Enterovirus (NC_001859), Human Rhinovirus (NC_001617) and Hepatitis C virus (NC_004102) [26] [27] [28] ) were downloaded into IRSS and ran UTR2SQ.pl program to proceed RNA secondary structure prediction (see Figure 1 ). First, the IRSS search capability is evaluated while virus genomes sequences were substituted for the entire UTRdb. The known IRES element which was used for RNA comparison was selected such as HCV IRES domain III structure for example. ./cache/cord-264678-wt0lvhfl.txt ./txt/cord-264678-wt0lvhfl.txt