id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-264159-e9071tyv	Lin, Weikang Nicholas	The Role of Single-Cell Technology in the Study and Control of Infectious Diseases	2020-06-10		.txt	text/plain	13339	580	36	In pathophysiological studies of infectious disease, single-cell omics offer excellent spatial-temporal resolution that help to not only reconstruct the uneven subcellular distribution of pathogen across the entire host cell population, but also reveal the sequence of immune events accompanied by the change of immune cell profiles. Moreover, viral mutation can be correlated with host gene expression status at the single-cell level to further investigate their potential mutual effect on one another throughout the course of infection and reveal the dynamic host responses and pathogen adaptations in the progression of infection [32] . Technologies that enable the simultaneous measurement of multiple parameters facilitate high-resolution characterization of transcripts and protein at the single-cell level and boost our understanding of how host immune responses are initiated and orchestrated against infection. As covered earlier in this review, the main applications of scRNA-seq in infectious disease study comprise of the following: (1) studying effect of host cell heterogeneity on infection, (2) identifying host immune responses, and (3) antibody discovery.	./cache/cord-264159-e9071tyv.txt	./txt/cord-264159-e9071tyv.txt