id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256918-mauzesor	Domingo, Esteban	Quasispecies and the implications for virus persistence and escape	1998-07-15		.txt	text/plain	2093	112	38	Objectives: To discuss indeterminations inherent to a quasispecies structure and to the analytical procedures to define it, biological implications of quasispecies, and the need to take into account this type of population structure, in order to design effective strategies to prevent and control diseases caused by highly variable viruses. Results: Quasispecies have many biological implications, extending from viral pathogenesis to the emergence of new pathogens, rapid antigenic variation, and alterations in cell tropism, virulence, host range and viral gene expression. Since adaptability of RNA viruses is key to viral pathogenesis and strategies for disease control, it would seem obvious that quasispecies should have been regarded as highly relevant to these questions (Domingo, 1989 (Domingo, , 1996 Domingo and Holland, 1992; Duarte et al., 1994; Novella et al., 1995) . The evolution of an RNA virus may be rapid or slow, but mutant swarms are always hidden in their replicating genome populations.	./cache/cord-256918-mauzesor.txt	./txt/cord-256918-mauzesor.txt