id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-255607-dbexsugq	Wu, Yang	Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3	2020-05-31		.txt	text/plain	6410	357	48	Our preliminary results revealed that endogenous TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3), the key components in the IFN signaling pathway were downregulated in PEDV infected IPEC-J2 cells by iTRAQ analysis. Moreover, PEDV nsp15 can directly degrade the RNA levels of TBK1 and IRF3 dependent on its EndoU activity to suppress IFN production and constrain the induction of IFN stimulated genes (ISGs), by which PEDV antagonizes the host innate response to facilitate its replication. Previous studies suggest that PEDV can restrain host innate immune response by different strategies, such as by degradation or cleavage of key factors essential the IFN signaling pathway [25, 26] , competitive interaction between viral encoded proteins and modulators for IFN production [27, 28] , or localization changes of antiviral components [29] .	./cache/cord-255607-dbexsugq.txt	./txt/cord-255607-dbexsugq.txt