id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-048322-5eqdrd52	Aigner, Achim	Delivery Systems for the Direct Application of siRNAs to Induce RNA Interference (RNAi) In Vivo	2006-05-18		.txt	text/plain	7333	363	41	The antitumorigenic effects of PEI/siRNA-mediated in vivo gene-targeting of tumor-relevant proteins like in mouse tumor xenograft models are described. The efficient protection against enzymatic or nonenzymatic degradation is particularly important for RNA molecules including siRNAs. In fact, while the therapeutic potential of siRNAs for the treatment of various diseases is in principle very promising, limitations of transfer vectors may turn out to be rate-limiting in the development of RNAi-based therapeutic strategies. Their ultimate success, however, will Figure 4 : Systemic treatment of mice with PEI-complexed HER-2-specific siRNAs leads to reduced growth of subcutaneous SKOV-3 tumor xenografts due to decreased HER-2 expression. RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo Atelocollagenmediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo	./cache/cord-048322-5eqdrd52.txt	./txt/cord-048322-5eqdrd52.txt