id author title date pages extension mime words sentences flesch summary cache txt cord-035110-5lkzhjfh Zhu, Le Isolation and characterization of exosomes for cancer research 2020-11-10 .txt text/plain 14672 743 34 Another study reported that triple-negative breast cancer (TNBC) cells can activate stromal cells by releasing exosomes containing unshielded RNAs that mimic viral components to co-opt anti-viral immune responses, thereby promoting tumor growth [115] . Furthermore, CAF-derived exosomes contain intact metabolites, including amino acids, lipids, and TCA-cycle intermediates, which are internalized by prostate cancer cells to promote tumor growth [122] . EGFR carried in exosomes secreted from gastric cancer cells can be delivered to the liver and integrated into the plasma membrane of liver stromal cells, thus favoring the development of a liver-like microenvironment and promoting liver-specific metastasis [147] . In addition, abundant studies have demonstrated that tumor-derived exosomes can modulate the cell biology of MDSCs, including increasing their expansion, promoting their activation, and enhancing their immunosuppressive function [162] . Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E ./cache/cord-035110-5lkzhjfh.txt ./txt/cord-035110-5lkzhjfh.txt