id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-023865-6rafp3x3	Surjit, Milan	The Nucleocapsid Protein of the SARS Coronavirus: Structure, Function and Therapeutic Potential	2009-07-22		.txt	text/plain	9210	448	45	Towards the end of the article, we will also discuss some recent reports regarding the possible clinically relevant use of the nucleocapsid protein, as a candidate diagnostic tool and vaccine against SARS-CoV infection. Interestingly, biochemically mediated inhibition of GSK3 activity in SARS-CoV infected cells also leads to around 80% reduction in viral titer and subsequent induction of a virus-induced cytopathic effect. Further, S-phase specific gene products like cyclin E and CDK2 were found to be downregulated in SARS-CoV infected cell lysate, which suggested that the observed phenomenon may be relevant in vivo. Based on this observation, Palese's laboratory has studied the IFN inhibitory property of different SARS-CoV proteins, which revealed that ORF3, ORF6 as well as the N-protein have the ability to independently inhibit IFN production through different mechanisms. Intracellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein: absence of nucleolar accumulation during infection and after expression as a recombinant protein in vero cells	./cache/cord-023865-6rafp3x3.txt	./txt/cord-023865-6rafp3x3.txt