id author title date pages extension mime words sentences flesch summary cache txt cord-021481-tvs1pnib Singh, Gatikrushna Cellular RNA Helicases Support Early and Late Events in Retroviral Replication 2018-08-17 .txt text/plain 6039 359 43 Introns FIGURE 7.1 Critical events in HIV-1 replication are supported by RNA helicases Early steps in HIV-1 replication involve reverse transcription in the cytosol of capsid-associated viral RNA (n = 2) to double-stranded cDNA that transits the nuclear pore and integrates into the host chromosome (blue lines) to form a provirus (red line surrounded by black dotted line) with the involvement of at least two RHs (DHX9, DDX19A). The study of CTE/TAP activity significantly expanded knowledge of nucleocytoplasmic transport of cell mRNAs and regulation by many virus RNAs. Ten years ago and in context RSV, a genetically simple avian retrovirus, DDX19B/yeast DBP5 was determined to facilitate nuclear export of genome-length unspliced RNA (LeBlanc et al., 2007) . Influenza A virus polymerase recruits the RNA helicase DDX19 to promote the nuclear export of viral mRNAs RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs ./cache/cord-021481-tvs1pnib.txt ./txt/cord-021481-tvs1pnib.txt