id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-019076-4qu9j953	Ulferts, Rachel	Expression and Functions of SARS Coronavirus Replicative Proteins	2009-07-22		.txt	text/plain	10036	516	52	In this chapter, we review our current understanding of the expression and functions of key replicative enzymes, such as RNA polymerases, helicase, ribonucleases, ribose-2′-O-methyltransferase and other replicase gene-encoded proteins involved in genome expression, virus–host interactions and other processes. The RTC includes the key replicative proteins of the virus, such as RNA-dependent RNA polymerase (RdRp) and helicase activities, as well as enzymes that are thought to be involved in the processing and modification of viral and/or cellular RNAs, such as primase, endoribonuclease, exoribonuclease and ribose-2 0 -O-methyltransferase activities (for recent reviews, see Masters 2006; Ziebuhr 2005 Ziebuhr , 2008 . SARS-CoV pp1a and pp1ab are co-and post-translationally processed by two proteases, a papain-like protease (PL pro ) and the main protease (M pro , nsp5), resulting in 16 mature products called nonstructural proteins (nsps) 1-16 The 5 0 -terminal ORF(s) expressed from specific RNAs is/are shown as boxes.	./cache/cord-019076-4qu9j953.txt	./txt/cord-019076-4qu9j953.txt