id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016209-6p9btua0	Merl, S.	Targeting Viral Heart Disease by RNA Interference	2008		.txt	text/plain	7170	429	41	The use of highly specific siRNAs targeting distinct regions of the viral genome ( Fig. 1) as well as host genes that are relevant for virus entry and maturation represents a novel therapeutic strategy to cure or attenuate in particular coxsackievirus-mediated diseases. Several laboratories obtained significant inhibition of the HIV-1 replication applying both synthetic and vector-derived siRNAs/shRNAs directed against the viral genome and HIV-encoded RNAs, such as the TAR element, tat, rev, gag, env, vif, nef and reverse transcriptase (Boden et al. In our previous work, the application of the most effective siRNA directed against the RNA dependent RNA polymerase 3D resulted in an approximately fourfold prolonged survival of coxsackievirus-infected cells and an inhibition of viral replication by more than 10 5 -fold compared to control siRNAs (Merl and Wessely 2007) . Even though previous studies reported efficient suppression of hepatitis C virus replication by siRNAs targeting single-stranded regions inbetween two stem-loop motifs of the viral 5′ UTR (Yokota et al.	./cache/cord-016209-6p9btua0.txt	./txt/cord-016209-6p9btua0.txt