id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012552-porty653	Tan, Kun	The role of the NMD factor UPF3B in olfactory sensory neurons	2020-08-10		.txt	text/plain	11512	600	52	Single-cell RNA-sequencing (scRNA-seq) analysis demonstrated considerable heterogeneity of olfactory sensory neuron (OSN) cell populations in wild-type (WT) mice, and revealed that UPF3B loss influences specific subsets of these cell populations. RNA-seq and Ribotag analyses identified classes of mRNAs expressed and translated at different levels in WT and Upf3b-null mOSNs. Integrating multiple computational approaches, UPF3B-dependent NMD target transcripts that are candidates to mediate the functions of NMD in mOSNs were identified in vivo. We identified UPF3B-regulated genes in mOSNs by performing RNA-seq analysis on FACSpurified mOSNs (YFP+ cells) from R26-eYFP; Omp-Cre mice (Figure 1-figure supplement 1B) . Among the antimicrobial genes expressed and upregulated in Upf3b-null OSN precursors and OSNs was Camp (also known as 'Cramp'), which encodes a member of the cathelicidin family of antimicrobial peptides that has an important role in the defense against microbial infections, and functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation (Zhang and Gallo, 2016) .	./cache/cord-012552-porty653.txt	./txt/cord-012552-porty653.txt