id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010120-mqvm9zn4	Dinman, Jonathan D.	Ribosomal frameshifting in yeast viruses	2004-01-29		.txt	text/plain	6721	406	64	Ribosomal frameshifting is different from frameshift suppression in that these events are directed by specific mRNA sequences and structures, rather than being a consequence of mutations in host gene products, e.g. tRNAs containing four base anticodon loops. In eukaryotes, frameshifting in the +1, or 3' direction has been observed in the Ty retrotransposable elements in yeast (for review, see reference 25), and in the ornithine decarboxylase antizyme gene in mammalian ~e l l s .~~,~~ In Tyl and Ty3, +1 they splice their RNA.4 I: s6 All of these classes ribosomal frameshifting between the T Y A and T Y B genes in Tyl and the GAG3 and POL3 genes in Ty3 also results in the production of Gag-Pol fusion proteins. A longer ribosomal pause over the slippery site would follow, yielding increased efficiencies of -1 ribosomal frame~hifting.~.'~ A weak point of this model is that, in some mRNA pseudoknots, stem 1 is only five or six base pairs in slippery site, eliminating frameshifting.	./cache/cord-010120-mqvm9zn4.txt	./txt/cord-010120-mqvm9zn4.txt