id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006068-w3if1hns	Marshak-Rothstein, Ann	Toll-like receptors in systemic autoimmune disease	2006		.txt	text/plain	10093	442	41	This Review summarizes recent in vitro and in vivo studies that point to an important connection between DNA-and RNA-containing immune complexes, the production of type I interferons (IFNs; that is, IFNα and IFNβ), the activation of TLRs and subsequent events in the development and/or the progression of systemic autoimmune diseases. . b | IFNα upregulates expression of Toll-like receptor 7 (TLR7) by B cells, promotes cell death and increased release of certain RNA autoantigens, and primes pDCs to respond more effectively to immune complexes. A limited number of studies have now provided data consistent with the idea that TLR7 and TLR9 have key roles in the production of pathogenic autoantibodies and/or in the development of clinical features of autoimmunity in experimental animals ( Mice that are homozygous for the lpr mutation do not express a functional form of the death receptor CD95 (also known as FAS), and they develop a lymphoproliferative disease that is similar to Canale-Smith syndrome in humans.	./cache/cord-006068-w3if1hns.txt	./txt/cord-006068-w3if1hns.txt