id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003597-zj3w9ptj	Altman, Matthew C.	Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children	2019-04-08		.txt	text/plain	13552	661	44	We combined nasal virus PCR, nasal and peripheral blood cell differentials, and nasal and blood RNA-seq for serial sample collections at baseline and longitudinally during episodes when participants reported cold symptoms to determine the key molecular pathways associated with subsequent asthma exacerbations. The primary aim of the study was to identify patterns of gene expression induced during events that progressed to asthma exacerbations (exacerbation, Ex + ), defined by clinical symptoms that resulted in systemic corticosteroid use within 10 d of cold Fig. 1 | Study design and primary and secondary endpoints. From nasal and blood samples, we combined measured cell percentages with RNA-seq data and used cell deconvolution and WGCNA to construct and validate a repertoire of 94 distinct gene expression modules representing a diverse array of biological functions (Supplementary Fig. 1 and Supplementary Table 1 ).	./cache/cord-003597-zj3w9ptj.txt	./txt/cord-003597-zj3w9ptj.txt