id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002764-px0cz6qn	Lin, Yuan	Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs	2017-11-17		.txt	text/plain	8369	429	51	These were based on fusions of an IDR derived from the RNA granule protein FUS (fused in sarcoma) to a multivalent poly-Src homology 3 (SH3) domain protein that phase-separates when mixed with a poly-proline–rich-motif (polyPRM) ligand. These were based on fusions of an IDR derived from the RNA granule protein FUS (fused in sarcoma) to a multivalent poly-Src homology 3 (SH3) domain protein that phase-separates when mixed with a poly-proline-rich-motif (polyPRM) ligand. Tyrosine mutations also block recruitment of IDRs into hydrogels and/or phase-separated liquids formed by the RNA-binding protein hnRNPA2 (47) and FUS (29) , as well as into RNA granules in cells (29) . We found that, when tethered to a polySH3 domain protein that phase-separates when mixed with a cognate poly-proline-rich motif (polyPRM) ligand, wildtype FUS decreases the threshold concentration for LLPS by 8-fold.	./cache/cord-002764-px0cz6qn.txt	./txt/cord-002764-px0cz6qn.txt