id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001228-4eh22ek7	Ofori, Leslie O.	High-Affinity Recognition of HIV-1 Frameshift-Stimulating RNA Alters Frameshifting in Vitro and Interferes with HIV-1 Infectivity	2014-01-05		.txt	text/plain	6288	339	53	32 Thus, as far as we are aware, there are no reported examples of synthetic molecules able to alter HIV-1 frameshifting and interfere with viral infectivity via selective, high-affinity binding to the FSS RNA. Building on our laboratory's longstanding interest in understanding the factors that drive affinity and sequence selectivity in small molecule recognition of RNA, 33 we previously reported the use of an 11,325-member resin-bound dynamic combinatorial library 34 (designed based on the structure of DNA-binding, bisintercalating peptide antibiotics) to identify a compound (1) able to bind the HIV-1 FSS upper stem-loop with moderate affinity (K D = 4.1 ± 2.4 μM immobilized on an surface plasmon resonance (SPR) chip via one of its amine groups; K D = 350 ± 110 nM in solution as measured by fluorescence 35 ) and good selectivity.	./cache/cord-001228-4eh22ek7.txt	./txt/cord-001228-4eh22ek7.txt