id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000372-wzwpyvll	Castelló, Alfredo	The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases	2011-04-14		.txt	text/plain	16333	781	45	These findings are in agreement with the fact that host mRNA transcription takes place in 2A pro -expressing cells when both translation and RNA nuclear export are inhibited, upon cleavage of eIF4G and Nups [17] . In this regard, PV 2A pro has been very useful for examining the requirements for eIF4G to translate different cellular or viral mRNAs. In addition to this, in this paper, we have highlighted the role of PV 2A pro not only in the processing of the poliovirus polyprotein but also in the interaction with the host-cell. In particular, PV 2A pro cleaves cell proteins involved in transcription, pre-mRNA splicing, nucleus/cytoplasm transport and translation, in order to hijack those host functions and to concentrate the cellular resources on the production of the viral progeny.	./cache/cord-000372-wzwpyvll.txt	./txt/cord-000372-wzwpyvll.txt