id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000088-1xgjdhkx	Faria, Nuno R	Rooting human parechovirus evolution in time	2009-07-15		.txt	text/plain	4011	214	51	Using both strict and relaxed clock Bayesian phylogenetics we investigated 1) the substitutions rates of the structural P1 and capsid VP1 regions and 2) evolutionary timescale of currently circulating HPeV lineages. Their evolutionary history and population dynamics can be reconstructed by means of genealogy-based coalescent approaches using nucleotide sequences sampled over an epidemiological time frame in order to estimate timed viral ancestry as well as the rates of genetic change [27, 29] . We first identified the best-fitting substitution model for the HPeV sequences using the Modelgenerator package (GTR + Γ) [35] , and tested whether the evolution of the P1 and VP1 genetic regions was better described by a strict or relaxed lognormal molecular clock. The Bayesian analysis presented here first indicates that the structural P1 and the capsid VP1 region of this viral species evolve at a high rate of evolutionary change (~10 -3 substitutions per site per year).	./cache/cord-000088-1xgjdhkx.txt	./txt/cord-000088-1xgjdhkx.txt