id sid tid token lemma pos cord-026384-ejk9wjr1 1 1 key key NN cord-026384-ejk9wjr1 1 2 : : : cord-026384-ejk9wjr1 2 1 cord-026384-ejk9wjr1 cord-026384-ejk9wjr1 NNS cord-026384-ejk9wjr1 2 2 authors author NNS cord-026384-ejk9wjr1 2 3 : : : cord-026384-ejk9wjr1 3 1 Crilly Crilly NNP cord-026384-ejk9wjr1 3 2 , , , cord-026384-ejk9wjr1 3 3 Colin Colin NNP cord-026384-ejk9wjr1 3 4 J. J. NNP cord-026384-ejk9wjr1 3 5 ; ; : cord-026384-ejk9wjr1 3 6 Haneuse Haneuse NNP cord-026384-ejk9wjr1 3 7 , , , cord-026384-ejk9wjr1 3 8 Sebastien Sebastien NNP cord-026384-ejk9wjr1 3 9 ; ; : cord-026384-ejk9wjr1 3 10 Litt Litt NNP cord-026384-ejk9wjr1 3 11 , , , cord-026384-ejk9wjr1 3 12 Jonathan Jonathan NNP cord-026384-ejk9wjr1 3 13 S. S. NNP cord-026384-ejk9wjr1 3 14 title title NN cord-026384-ejk9wjr1 3 15 : : : cord-026384-ejk9wjr1 4 1 Predicting predict VBG cord-026384-ejk9wjr1 4 2 the the DT cord-026384-ejk9wjr1 4 3 outcomes outcome NNS cord-026384-ejk9wjr1 4 4 of of IN cord-026384-ejk9wjr1 4 5 preterm preterm JJ cord-026384-ejk9wjr1 4 6 neonates neonate NNS cord-026384-ejk9wjr1 4 7 beyond beyond IN cord-026384-ejk9wjr1 4 8 the the DT cord-026384-ejk9wjr1 4 9 neonatal neonatal JJ cord-026384-ejk9wjr1 4 10 intensive intensive JJ cord-026384-ejk9wjr1 4 11 care care NN cord-026384-ejk9wjr1 4 12 unit unit NN cord-026384-ejk9wjr1 4 13 : : : cord-026384-ejk9wjr1 4 14 What what WP cord-026384-ejk9wjr1 4 15 are be VBP cord-026384-ejk9wjr1 4 16 we -PRON- PRP cord-026384-ejk9wjr1 4 17 missing miss VBG cord-026384-ejk9wjr1 4 18 ? ? . cord-026384-ejk9wjr1 5 1 date date NN cord-026384-ejk9wjr1 5 2 : : : cord-026384-ejk9wjr1 5 3 2020 2020 CD cord-026384-ejk9wjr1 5 4 - - HYPH cord-026384-ejk9wjr1 5 5 05 05 CD cord-026384-ejk9wjr1 5 6 - - HYPH cord-026384-ejk9wjr1 5 7 19 19 CD cord-026384-ejk9wjr1 5 8 journal journal NN cord-026384-ejk9wjr1 5 9 : : : cord-026384-ejk9wjr1 6 1 Pediatr Pediatr NNP cord-026384-ejk9wjr1 6 2 Res Res NNP cord-026384-ejk9wjr1 6 3 DOI DOI NNP cord-026384-ejk9wjr1 6 4 : : : cord-026384-ejk9wjr1 6 5 10.1038 10.1038 CD cord-026384-ejk9wjr1 6 6 / / SYM cord-026384-ejk9wjr1 6 7 s41390 s41390 CD cord-026384-ejk9wjr1 6 8 - - HYPH cord-026384-ejk9wjr1 6 9 020 020 CD cord-026384-ejk9wjr1 6 10 - - HYPH cord-026384-ejk9wjr1 6 11 0968 0968 CD cord-026384-ejk9wjr1 6 12 - - SYM cord-026384-ejk9wjr1 6 13 5 5 CD cord-026384-ejk9wjr1 7 1 sha sha NNP cord-026384-ejk9wjr1 7 2 : : : cord-026384-ejk9wjr1 7 3 1327e3a53273b298098892f88ce6388793aa703e 1327e3a53273b298098892f88ce6388793aa703e CD cord-026384-ejk9wjr1 7 4 doc_id doc_id CD cord-026384-ejk9wjr1 8 1 : : : cord-026384-ejk9wjr1 8 2 26384 26384 CD cord-026384-ejk9wjr1 8 3 cord_uid cord_uid NNS cord-026384-ejk9wjr1 8 4 : : : cord-026384-ejk9wjr1 9 1 ejk9wjr1 ejk9wjr1 NNS cord-026384-ejk9wjr1 9 2 ABSTRACT ABSTRACT NNP cord-026384-ejk9wjr1 9 3 : : : cord-026384-ejk9wjr1 10 1 Preterm Preterm NNP cord-026384-ejk9wjr1 10 2 infants infant NNS cord-026384-ejk9wjr1 10 3 are be VBP cord-026384-ejk9wjr1 10 4 a a DT cord-026384-ejk9wjr1 10 5 population population NN cord-026384-ejk9wjr1 10 6 at at IN cord-026384-ejk9wjr1 10 7 high high JJ cord-026384-ejk9wjr1 10 8 risk risk NN cord-026384-ejk9wjr1 10 9 for for IN cord-026384-ejk9wjr1 10 10 mortality mortality NN cord-026384-ejk9wjr1 10 11 and and CC cord-026384-ejk9wjr1 10 12 adverse adverse JJ cord-026384-ejk9wjr1 10 13 health health NN cord-026384-ejk9wjr1 10 14 outcomes outcome NNS cord-026384-ejk9wjr1 10 15 . . . cord-026384-ejk9wjr1 11 1 With with IN cord-026384-ejk9wjr1 11 2 recent recent JJ cord-026384-ejk9wjr1 11 3 improvements improvement NNS cord-026384-ejk9wjr1 11 4 in in IN cord-026384-ejk9wjr1 11 5 survival survival NN cord-026384-ejk9wjr1 11 6 to to IN cord-026384-ejk9wjr1 11 7 childhood childhood NN cord-026384-ejk9wjr1 11 8 , , , cord-026384-ejk9wjr1 11 9 increasing increase VBG cord-026384-ejk9wjr1 11 10 attention attention NN cord-026384-ejk9wjr1 11 11 is be VBZ cord-026384-ejk9wjr1 11 12 being be VBG cord-026384-ejk9wjr1 11 13 paid pay VBN cord-026384-ejk9wjr1 11 14 to to IN cord-026384-ejk9wjr1 11 15 risk risk NN cord-026384-ejk9wjr1 11 16 of of IN cord-026384-ejk9wjr1 11 17 long long JJ cord-026384-ejk9wjr1 11 18 - - HYPH cord-026384-ejk9wjr1 11 19 term term NN cord-026384-ejk9wjr1 11 20 morbidity morbidity NN cord-026384-ejk9wjr1 11 21 , , , cord-026384-ejk9wjr1 11 22 specifically specifically RB cord-026384-ejk9wjr1 11 23 during during IN cord-026384-ejk9wjr1 11 24 childhood childhood NN cord-026384-ejk9wjr1 11 25 and and CC cord-026384-ejk9wjr1 11 26 young young JJ cord-026384-ejk9wjr1 11 27 - - HYPH cord-026384-ejk9wjr1 11 28 adulthood adulthood NN cord-026384-ejk9wjr1 11 29 . . . cord-026384-ejk9wjr1 12 1 Although although IN cord-026384-ejk9wjr1 12 2 numerous numerous JJ cord-026384-ejk9wjr1 12 3 tools tool NNS cord-026384-ejk9wjr1 12 4 for for IN cord-026384-ejk9wjr1 12 5 predicting predict VBG cord-026384-ejk9wjr1 12 6 the the DT cord-026384-ejk9wjr1 12 7 functional functional JJ cord-026384-ejk9wjr1 12 8 outcomes outcome NNS cord-026384-ejk9wjr1 12 9 of of IN cord-026384-ejk9wjr1 12 10 preterm preterm JJ cord-026384-ejk9wjr1 12 11 neonates neonate NNS cord-026384-ejk9wjr1 12 12 have have VBP cord-026384-ejk9wjr1 12 13 been be VBN cord-026384-ejk9wjr1 12 14 developed develop VBN cord-026384-ejk9wjr1 12 15 in in IN cord-026384-ejk9wjr1 12 16 the the DT cord-026384-ejk9wjr1 12 17 past past JJ cord-026384-ejk9wjr1 12 18 three three CD cord-026384-ejk9wjr1 12 19 decades decade NNS cord-026384-ejk9wjr1 12 20 , , , cord-026384-ejk9wjr1 12 21 no no DT cord-026384-ejk9wjr1 12 22 studies study NNS cord-026384-ejk9wjr1 12 23 have have VBP cord-026384-ejk9wjr1 12 24 provided provide VBN cord-026384-ejk9wjr1 12 25 a a DT cord-026384-ejk9wjr1 12 26 comprehensive comprehensive JJ cord-026384-ejk9wjr1 12 27 overview overview NN cord-026384-ejk9wjr1 12 28 of of IN cord-026384-ejk9wjr1 12 29 these these DT cord-026384-ejk9wjr1 12 30 tools tool NNS cord-026384-ejk9wjr1 12 31 , , , cord-026384-ejk9wjr1 12 32 along along IN cord-026384-ejk9wjr1 12 33 with with IN cord-026384-ejk9wjr1 12 34 their -PRON- PRP$ cord-026384-ejk9wjr1 12 35 strengths strength NNS cord-026384-ejk9wjr1 12 36 and and CC cord-026384-ejk9wjr1 12 37 weaknesses weakness NNS cord-026384-ejk9wjr1 12 38 . . . cord-026384-ejk9wjr1 13 1 The the DT cord-026384-ejk9wjr1 13 2 purpose purpose NN cord-026384-ejk9wjr1 13 3 of of IN cord-026384-ejk9wjr1 13 4 this this DT cord-026384-ejk9wjr1 13 5 article article NN cord-026384-ejk9wjr1 13 6 is be VBZ cord-026384-ejk9wjr1 13 7 to to TO cord-026384-ejk9wjr1 13 8 provide provide VB cord-026384-ejk9wjr1 13 9 an an DT cord-026384-ejk9wjr1 13 10 in in IN cord-026384-ejk9wjr1 13 11 - - HYPH cord-026384-ejk9wjr1 13 12 depth depth NN cord-026384-ejk9wjr1 13 13 , , , cord-026384-ejk9wjr1 13 14 narrative narrative NN cord-026384-ejk9wjr1 13 15 review review NN cord-026384-ejk9wjr1 13 16 of of IN cord-026384-ejk9wjr1 13 17 the the DT cord-026384-ejk9wjr1 13 18 current current JJ cord-026384-ejk9wjr1 13 19 risk risk NN cord-026384-ejk9wjr1 13 20 models model NNS cord-026384-ejk9wjr1 13 21 available available JJ cord-026384-ejk9wjr1 13 22 for for IN cord-026384-ejk9wjr1 13 23 predicting predict VBG cord-026384-ejk9wjr1 13 24 the the DT cord-026384-ejk9wjr1 13 25 functional functional JJ cord-026384-ejk9wjr1 13 26 outcomes outcome NNS cord-026384-ejk9wjr1 13 27 of of IN cord-026384-ejk9wjr1 13 28 preterm preterm JJ cord-026384-ejk9wjr1 13 29 neonates neonate NNS cord-026384-ejk9wjr1 13 30 . . . cord-026384-ejk9wjr1 14 1 A a DT cord-026384-ejk9wjr1 14 2 total total NN cord-026384-ejk9wjr1 14 3 of of IN cord-026384-ejk9wjr1 14 4 32 32 CD cord-026384-ejk9wjr1 14 5 studies study NNS cord-026384-ejk9wjr1 14 6 describing describe VBG cord-026384-ejk9wjr1 14 7 43 43 CD cord-026384-ejk9wjr1 14 8 separate separate JJ cord-026384-ejk9wjr1 14 9 models model NNS cord-026384-ejk9wjr1 14 10 were be VBD cord-026384-ejk9wjr1 14 11 considered consider VBN cord-026384-ejk9wjr1 14 12 . . . cord-026384-ejk9wjr1 15 1 We -PRON- PRP cord-026384-ejk9wjr1 15 2 found find VBD cord-026384-ejk9wjr1 15 3 that that IN cord-026384-ejk9wjr1 15 4 most most JJS cord-026384-ejk9wjr1 15 5 studies study NNS cord-026384-ejk9wjr1 15 6 used use VBD cord-026384-ejk9wjr1 15 7 similar similar JJ cord-026384-ejk9wjr1 15 8 physiologic physiologic JJ cord-026384-ejk9wjr1 15 9 variables variable NNS cord-026384-ejk9wjr1 15 10 and and CC cord-026384-ejk9wjr1 15 11 standard standard JJ cord-026384-ejk9wjr1 15 12 regression regression NN cord-026384-ejk9wjr1 15 13 techniques technique NNS cord-026384-ejk9wjr1 15 14 to to TO cord-026384-ejk9wjr1 15 15 develop develop VB cord-026384-ejk9wjr1 15 16 models model NNS cord-026384-ejk9wjr1 15 17 that that WDT cord-026384-ejk9wjr1 15 18 primarily primarily RB cord-026384-ejk9wjr1 15 19 predict predict VBP cord-026384-ejk9wjr1 15 20 the the DT cord-026384-ejk9wjr1 15 21 risk risk NN cord-026384-ejk9wjr1 15 22 of of IN cord-026384-ejk9wjr1 15 23 poor poor JJ cord-026384-ejk9wjr1 15 24 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 15 25 outcomes outcome NNS cord-026384-ejk9wjr1 15 26 . . . cord-026384-ejk9wjr1 16 1 With with IN cord-026384-ejk9wjr1 16 2 a a DT cord-026384-ejk9wjr1 16 3 recently recently RB cord-026384-ejk9wjr1 16 4 expanded expand VBN cord-026384-ejk9wjr1 16 5 knowledge knowledge NN cord-026384-ejk9wjr1 16 6 regarding regard VBG cord-026384-ejk9wjr1 16 7 the the DT cord-026384-ejk9wjr1 16 8 many many JJ cord-026384-ejk9wjr1 16 9 factors factor NNS cord-026384-ejk9wjr1 16 10 that that WDT cord-026384-ejk9wjr1 16 11 affect affect VBP cord-026384-ejk9wjr1 16 12 neurodevelopment neurodevelopment JJ cord-026384-ejk9wjr1 16 13 and and CC cord-026384-ejk9wjr1 16 14 other other JJ cord-026384-ejk9wjr1 16 15 important important JJ cord-026384-ejk9wjr1 16 16 outcomes outcome NNS cord-026384-ejk9wjr1 16 17 , , , cord-026384-ejk9wjr1 16 18 as as RB cord-026384-ejk9wjr1 16 19 well well RB cord-026384-ejk9wjr1 16 20 as as IN cord-026384-ejk9wjr1 16 21 a a DT cord-026384-ejk9wjr1 16 22 better well JJR cord-026384-ejk9wjr1 16 23 understanding understanding NN cord-026384-ejk9wjr1 16 24 of of IN cord-026384-ejk9wjr1 16 25 the the DT cord-026384-ejk9wjr1 16 26 limitations limitation NNS cord-026384-ejk9wjr1 16 27 of of IN cord-026384-ejk9wjr1 16 28 traditional traditional JJ cord-026384-ejk9wjr1 16 29 analytic analytic JJ cord-026384-ejk9wjr1 16 30 methods method NNS cord-026384-ejk9wjr1 16 31 , , , cord-026384-ejk9wjr1 16 32 we -PRON- PRP cord-026384-ejk9wjr1 16 33 argue argue VBP cord-026384-ejk9wjr1 16 34 that that IN cord-026384-ejk9wjr1 16 35 there there EX cord-026384-ejk9wjr1 16 36 is be VBZ cord-026384-ejk9wjr1 16 37 great great JJ cord-026384-ejk9wjr1 16 38 room room NN cord-026384-ejk9wjr1 16 39 for for IN cord-026384-ejk9wjr1 16 40 improvement improvement NN cord-026384-ejk9wjr1 16 41 in in IN cord-026384-ejk9wjr1 16 42 creating create VBG cord-026384-ejk9wjr1 16 43 risk risk NN cord-026384-ejk9wjr1 16 44 prediction prediction NN cord-026384-ejk9wjr1 16 45 tools tool NNS cord-026384-ejk9wjr1 16 46 for for IN cord-026384-ejk9wjr1 16 47 preterm preterm JJ cord-026384-ejk9wjr1 16 48 neonates neonate NNS cord-026384-ejk9wjr1 16 49 . . . cord-026384-ejk9wjr1 17 1 We -PRON- PRP cord-026384-ejk9wjr1 17 2 also also RB cord-026384-ejk9wjr1 17 3 consider consider VBP cord-026384-ejk9wjr1 17 4 the the DT cord-026384-ejk9wjr1 17 5 ethical ethical JJ cord-026384-ejk9wjr1 17 6 implications implication NNS cord-026384-ejk9wjr1 17 7 of of IN cord-026384-ejk9wjr1 17 8 utilizing utilize VBG cord-026384-ejk9wjr1 17 9 these these DT cord-026384-ejk9wjr1 17 10 tools tool NNS cord-026384-ejk9wjr1 17 11 for for IN cord-026384-ejk9wjr1 17 12 clinical clinical JJ cord-026384-ejk9wjr1 17 13 decision decision NN cord-026384-ejk9wjr1 17 14 - - HYPH cord-026384-ejk9wjr1 17 15 making making NN cord-026384-ejk9wjr1 17 16 . . . cord-026384-ejk9wjr1 18 1 IMPACT impact NN cord-026384-ejk9wjr1 18 2 : : : cord-026384-ejk9wjr1 19 1 Based base VBN cord-026384-ejk9wjr1 19 2 on on IN cord-026384-ejk9wjr1 19 3 a a DT cord-026384-ejk9wjr1 19 4 literature literature NN cord-026384-ejk9wjr1 19 5 review review NN cord-026384-ejk9wjr1 19 6 of of IN cord-026384-ejk9wjr1 19 7 risk risk NN cord-026384-ejk9wjr1 19 8 prediction prediction NN cord-026384-ejk9wjr1 19 9 models model NNS cord-026384-ejk9wjr1 19 10 for for IN cord-026384-ejk9wjr1 19 11 preterm preterm JJ cord-026384-ejk9wjr1 19 12 neonates neonate NNS cord-026384-ejk9wjr1 19 13 predicting predict VBG cord-026384-ejk9wjr1 19 14 functional functional JJ cord-026384-ejk9wjr1 19 15 outcomes outcome NNS cord-026384-ejk9wjr1 19 16 , , , cord-026384-ejk9wjr1 19 17 future future JJ cord-026384-ejk9wjr1 19 18 models model NNS cord-026384-ejk9wjr1 19 19 should should MD cord-026384-ejk9wjr1 19 20 aim aim VB cord-026384-ejk9wjr1 19 21 for for IN cord-026384-ejk9wjr1 19 22 more more RBR cord-026384-ejk9wjr1 19 23 consistent consistent JJ cord-026384-ejk9wjr1 19 24 outcomes outcome NNS cord-026384-ejk9wjr1 19 25 definitions definition NNS cord-026384-ejk9wjr1 19 26 , , , cord-026384-ejk9wjr1 19 27 standardized standardized JJ cord-026384-ejk9wjr1 19 28 assessment assessment NN cord-026384-ejk9wjr1 19 29 schedules schedule NNS cord-026384-ejk9wjr1 19 30 and and CC cord-026384-ejk9wjr1 19 31 measurement measurement NN cord-026384-ejk9wjr1 19 32 tools tool NNS cord-026384-ejk9wjr1 19 33 , , , cord-026384-ejk9wjr1 19 34 and and CC cord-026384-ejk9wjr1 19 35 consideration consideration NN cord-026384-ejk9wjr1 19 36 of of IN cord-026384-ejk9wjr1 19 37 risk risk NN cord-026384-ejk9wjr1 19 38 beyond beyond IN cord-026384-ejk9wjr1 19 39 physiologic physiologic JJ cord-026384-ejk9wjr1 19 40 antecedents antecedent NNS cord-026384-ejk9wjr1 19 41 . . . cord-026384-ejk9wjr1 20 1 Our -PRON- PRP$ cord-026384-ejk9wjr1 20 2 review review NN cord-026384-ejk9wjr1 20 3 provides provide VBZ cord-026384-ejk9wjr1 20 4 a a DT cord-026384-ejk9wjr1 20 5 comprehensive comprehensive JJ cord-026384-ejk9wjr1 20 6 analysis analysis NN cord-026384-ejk9wjr1 20 7 and and CC cord-026384-ejk9wjr1 20 8 critique critique NN cord-026384-ejk9wjr1 20 9 of of IN cord-026384-ejk9wjr1 20 10 risk risk NN cord-026384-ejk9wjr1 20 11 prediction prediction NN cord-026384-ejk9wjr1 20 12 models model NNS cord-026384-ejk9wjr1 20 13 developed develop VBN cord-026384-ejk9wjr1 20 14 for for IN cord-026384-ejk9wjr1 20 15 preterm preterm JJ cord-026384-ejk9wjr1 20 16 neonates neonate NNS cord-026384-ejk9wjr1 20 17 , , , cord-026384-ejk9wjr1 20 18 specifically specifically RB cord-026384-ejk9wjr1 20 19 predicting predict VBG cord-026384-ejk9wjr1 20 20 functional functional JJ cord-026384-ejk9wjr1 20 21 outcomes outcome NNS cord-026384-ejk9wjr1 20 22 instead instead RB cord-026384-ejk9wjr1 20 23 of of IN cord-026384-ejk9wjr1 20 24 mortality mortality NN cord-026384-ejk9wjr1 20 25 , , , cord-026384-ejk9wjr1 20 26 to to TO cord-026384-ejk9wjr1 20 27 reveal reveal VB cord-026384-ejk9wjr1 20 28 areas area NNS cord-026384-ejk9wjr1 20 29 of of IN cord-026384-ejk9wjr1 20 30 improvement improvement NN cord-026384-ejk9wjr1 20 31 for for IN cord-026384-ejk9wjr1 20 32 future future JJ cord-026384-ejk9wjr1 20 33 studies study NNS cord-026384-ejk9wjr1 20 34 aiming aim VBG cord-026384-ejk9wjr1 20 35 to to TO cord-026384-ejk9wjr1 20 36 develop develop VB cord-026384-ejk9wjr1 20 37 risk risk NN cord-026384-ejk9wjr1 20 38 prediction prediction NN cord-026384-ejk9wjr1 20 39 tools tool NNS cord-026384-ejk9wjr1 20 40 for for IN cord-026384-ejk9wjr1 20 41 this this DT cord-026384-ejk9wjr1 20 42 population population NN cord-026384-ejk9wjr1 20 43 . . . cord-026384-ejk9wjr1 21 1 To to IN cord-026384-ejk9wjr1 21 2 our -PRON- PRP$ cord-026384-ejk9wjr1 21 3 knowledge knowledge NN cord-026384-ejk9wjr1 21 4 , , , cord-026384-ejk9wjr1 21 5 this this DT cord-026384-ejk9wjr1 21 6 is be VBZ cord-026384-ejk9wjr1 21 7 the the DT cord-026384-ejk9wjr1 21 8 first first JJ cord-026384-ejk9wjr1 21 9 literature literature NN cord-026384-ejk9wjr1 21 10 review review NN cord-026384-ejk9wjr1 21 11 and and CC cord-026384-ejk9wjr1 21 12 narrative narrative NN cord-026384-ejk9wjr1 21 13 analysis analysis NN cord-026384-ejk9wjr1 21 14 of of IN cord-026384-ejk9wjr1 21 15 risk risk NN cord-026384-ejk9wjr1 21 16 prediction prediction NN cord-026384-ejk9wjr1 21 17 models model NNS cord-026384-ejk9wjr1 21 18 for for IN cord-026384-ejk9wjr1 21 19 preterm preterm JJ cord-026384-ejk9wjr1 21 20 neonates neonate NNS cord-026384-ejk9wjr1 21 21 regarding regard VBG cord-026384-ejk9wjr1 21 22 their -PRON- PRP$ cord-026384-ejk9wjr1 21 23 functional functional JJ cord-026384-ejk9wjr1 21 24 outcomes outcome NNS cord-026384-ejk9wjr1 21 25 . . . cord-026384-ejk9wjr1 22 1 Preterm Preterm NNP cord-026384-ejk9wjr1 22 2 infants infant NNS cord-026384-ejk9wjr1 22 3 have have VBP cord-026384-ejk9wjr1 22 4 long long RB cord-026384-ejk9wjr1 22 5 been be VBN cord-026384-ejk9wjr1 22 6 recognized recognize VBN cord-026384-ejk9wjr1 22 7 as as IN cord-026384-ejk9wjr1 22 8 a a DT cord-026384-ejk9wjr1 22 9 population population NN cord-026384-ejk9wjr1 22 10 at at IN cord-026384-ejk9wjr1 22 11 high high JJ cord-026384-ejk9wjr1 22 12 risk risk NN cord-026384-ejk9wjr1 22 13 for for IN cord-026384-ejk9wjr1 22 14 mortality mortality NN cord-026384-ejk9wjr1 22 15 and and CC cord-026384-ejk9wjr1 22 16 adverse adverse JJ cord-026384-ejk9wjr1 22 17 functional functional JJ cord-026384-ejk9wjr1 22 18 outcomes outcome NNS cord-026384-ejk9wjr1 22 19 , , , cord-026384-ejk9wjr1 22 20 including include VBG cord-026384-ejk9wjr1 22 21 cerebral cerebral JJ cord-026384-ejk9wjr1 22 22 palsy palsy JJ cord-026384-ejk9wjr1 22 23 and and CC cord-026384-ejk9wjr1 22 24 intellectual intellectual JJ cord-026384-ejk9wjr1 22 25 impairment impairment NN cord-026384-ejk9wjr1 22 26 . . . cord-026384-ejk9wjr1 23 1 1 1 LS cord-026384-ejk9wjr1 24 1 As as IN cord-026384-ejk9wjr1 24 2 mortality mortality NN cord-026384-ejk9wjr1 24 3 rates rate NNS cord-026384-ejk9wjr1 24 4 for for IN cord-026384-ejk9wjr1 24 5 preterm preterm JJ cord-026384-ejk9wjr1 24 6 neonates neonate NNS cord-026384-ejk9wjr1 24 7 decline decline VBP cord-026384-ejk9wjr1 24 8 and and CC cord-026384-ejk9wjr1 24 9 more more RBR cord-026384-ejk9wjr1 24 10 survive survive VB cord-026384-ejk9wjr1 24 11 to to IN cord-026384-ejk9wjr1 24 12 childhood childhood NN cord-026384-ejk9wjr1 24 13 , , , cord-026384-ejk9wjr1 24 14 2,3 2,3 CD cord-026384-ejk9wjr1 24 15 attention attention NN cord-026384-ejk9wjr1 24 16 has have VBZ cord-026384-ejk9wjr1 24 17 increasingly increasingly RB cord-026384-ejk9wjr1 24 18 turned turn VBN cord-026384-ejk9wjr1 24 19 towards towards IN cord-026384-ejk9wjr1 24 20 measuring measure VBG cord-026384-ejk9wjr1 24 21 longer long JJR cord-026384-ejk9wjr1 24 22 - - HYPH cord-026384-ejk9wjr1 24 23 term term NN cord-026384-ejk9wjr1 24 24 morbidities morbidity NNS cord-026384-ejk9wjr1 24 25 and and CC cord-026384-ejk9wjr1 24 26 related relate VBN cord-026384-ejk9wjr1 24 27 functional functional JJ cord-026384-ejk9wjr1 24 28 impairments impairment NNS cord-026384-ejk9wjr1 24 29 during during IN cord-026384-ejk9wjr1 24 30 childhood childhood NN cord-026384-ejk9wjr1 24 31 and and CC cord-026384-ejk9wjr1 24 32 young young JJ cord-026384-ejk9wjr1 24 33 - - HYPH cord-026384-ejk9wjr1 24 34 adulthood adulthood NN cord-026384-ejk9wjr1 24 35 , , , cord-026384-ejk9wjr1 24 36 as as RB cord-026384-ejk9wjr1 24 37 well well RB cord-026384-ejk9wjr1 24 38 as as IN cord-026384-ejk9wjr1 24 39 identifying identify VBG cord-026384-ejk9wjr1 24 40 risk risk NN cord-026384-ejk9wjr1 24 41 factors factor NNS cord-026384-ejk9wjr1 24 42 related relate VBN cord-026384-ejk9wjr1 24 43 to to IN cord-026384-ejk9wjr1 24 44 these these DT cord-026384-ejk9wjr1 24 45 complications complication NNS cord-026384-ejk9wjr1 24 46 . . . cord-026384-ejk9wjr1 25 1 4 4 LS cord-026384-ejk9wjr1 25 2 , , , cord-026384-ejk9wjr1 25 3 5 5 CD cord-026384-ejk9wjr1 26 1 While while IN cord-026384-ejk9wjr1 26 2 child child NN cord-026384-ejk9wjr1 26 3 - - HYPH cord-026384-ejk9wjr1 26 4 specific specific JJ cord-026384-ejk9wjr1 26 5 characteristics characteristic NNS cord-026384-ejk9wjr1 26 6 , , , cord-026384-ejk9wjr1 26 7 such such JJ cord-026384-ejk9wjr1 26 8 as as IN cord-026384-ejk9wjr1 26 9 gestational gestational JJ cord-026384-ejk9wjr1 26 10 age age NN cord-026384-ejk9wjr1 26 11 , , , cord-026384-ejk9wjr1 26 12 birth birth NN cord-026384-ejk9wjr1 26 13 weight weight NN cord-026384-ejk9wjr1 26 14 , , , cord-026384-ejk9wjr1 26 15 and and CC cord-026384-ejk9wjr1 26 16 sex sex NN cord-026384-ejk9wjr1 26 17 , , , cord-026384-ejk9wjr1 26 18 are be VBP cord-026384-ejk9wjr1 26 19 well well RB cord-026384-ejk9wjr1 26 20 established establish VBN cord-026384-ejk9wjr1 26 21 as as IN cord-026384-ejk9wjr1 26 22 predictors predictor NNS cord-026384-ejk9wjr1 26 23 of of IN cord-026384-ejk9wjr1 26 24 adverse adverse JJ cord-026384-ejk9wjr1 26 25 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 26 26 outcomes outcome NNS cord-026384-ejk9wjr1 26 27 , , , cord-026384-ejk9wjr1 26 28 6 6 CD cord-026384-ejk9wjr1 26 29 - - SYM cord-026384-ejk9wjr1 26 30 8 8 CD cord-026384-ejk9wjr1 26 31 recent recent JJ cord-026384-ejk9wjr1 26 32 work work NN cord-026384-ejk9wjr1 26 33 has have VBZ cord-026384-ejk9wjr1 26 34 identified identify VBN cord-026384-ejk9wjr1 26 35 additional additional JJ cord-026384-ejk9wjr1 26 36 factors factor NNS cord-026384-ejk9wjr1 26 37 , , , cord-026384-ejk9wjr1 26 38 including include VBG cord-026384-ejk9wjr1 26 39 bronchopulmonary bronchopulmonary JJ cord-026384-ejk9wjr1 26 40 dysplasia dysplasia NN cord-026384-ejk9wjr1 26 41 and and CC cord-026384-ejk9wjr1 26 42 family family NN cord-026384-ejk9wjr1 26 43 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 26 44 status status NN cord-026384-ejk9wjr1 26 45 , , , cord-026384-ejk9wjr1 26 46 that that WDT cord-026384-ejk9wjr1 26 47 are be VBP cord-026384-ejk9wjr1 26 48 correlated correlate VBN cord-026384-ejk9wjr1 26 49 with with IN cord-026384-ejk9wjr1 26 50 relevant relevant JJ cord-026384-ejk9wjr1 26 51 outcomes outcome NNS cord-026384-ejk9wjr1 26 52 , , , cord-026384-ejk9wjr1 26 53 such such JJ cord-026384-ejk9wjr1 26 54 as as IN cord-026384-ejk9wjr1 26 55 poor poor JJ cord-026384-ejk9wjr1 26 56 neuromotor neuromotor NN cord-026384-ejk9wjr1 26 57 performance performance NN cord-026384-ejk9wjr1 26 58 and and CC cord-026384-ejk9wjr1 26 59 low low JJ cord-026384-ejk9wjr1 26 60 intelligence intelligence NN cord-026384-ejk9wjr1 26 61 quotient quotient NN cord-026384-ejk9wjr1 26 62 at at IN cord-026384-ejk9wjr1 26 63 school school NN cord-026384-ejk9wjr1 26 64 age age NN cord-026384-ejk9wjr1 26 65 . . . cord-026384-ejk9wjr1 26 66 9 9 CD cord-026384-ejk9wjr1 27 1 In in IN cord-026384-ejk9wjr1 27 2 clinical clinical JJ cord-026384-ejk9wjr1 27 3 settings setting NNS cord-026384-ejk9wjr1 27 4 , , , cord-026384-ejk9wjr1 27 5 the the DT cord-026384-ejk9wjr1 27 6 assessment assessment NN cord-026384-ejk9wjr1 27 7 of of IN cord-026384-ejk9wjr1 27 8 prognosis prognosis NN cord-026384-ejk9wjr1 27 9 can can MD cord-026384-ejk9wjr1 27 10 vary vary VB cord-026384-ejk9wjr1 27 11 widely widely RB cord-026384-ejk9wjr1 27 12 across across IN cord-026384-ejk9wjr1 27 13 neonatologists neonatologist NNS cord-026384-ejk9wjr1 27 14 , , , cord-026384-ejk9wjr1 27 15 10 10 CD cord-026384-ejk9wjr1 27 16 making make VBG cord-026384-ejk9wjr1 27 17 a a DT cord-026384-ejk9wjr1 27 18 valid valid JJ cord-026384-ejk9wjr1 27 19 and and CC cord-026384-ejk9wjr1 27 20 reliable reliable JJ cord-026384-ejk9wjr1 27 21 predictive predictive JJ cord-026384-ejk9wjr1 27 22 model model NN cord-026384-ejk9wjr1 27 23 for for IN cord-026384-ejk9wjr1 27 24 long long JJ cord-026384-ejk9wjr1 27 25 - - HYPH cord-026384-ejk9wjr1 27 26 term term NN cord-026384-ejk9wjr1 27 27 outcomes outcome NNS cord-026384-ejk9wjr1 27 28 a a DT cord-026384-ejk9wjr1 27 29 highly highly RB cord-026384-ejk9wjr1 27 30 sought seek VBN cord-026384-ejk9wjr1 27 31 - - HYPH cord-026384-ejk9wjr1 27 32 after after IN cord-026384-ejk9wjr1 27 33 clinical clinical JJ cord-026384-ejk9wjr1 27 34 tool tool NN cord-026384-ejk9wjr1 27 35 . . . cord-026384-ejk9wjr1 28 1 Moreover moreover RB cord-026384-ejk9wjr1 28 2 , , , cord-026384-ejk9wjr1 28 3 predicting predict VBG cord-026384-ejk9wjr1 28 4 outcomes outcome NNS cord-026384-ejk9wjr1 28 5 is be VBZ cord-026384-ejk9wjr1 28 6 vital vital JJ cord-026384-ejk9wjr1 28 7 when when WRB cord-026384-ejk9wjr1 28 8 making make VBG cord-026384-ejk9wjr1 28 9 decisions decision NNS cord-026384-ejk9wjr1 28 10 regarding regard VBG cord-026384-ejk9wjr1 28 11 which which WDT cord-026384-ejk9wjr1 28 12 therapeutic therapeutic JJ cord-026384-ejk9wjr1 28 13 interventions intervention NNS cord-026384-ejk9wjr1 28 14 to to TO cord-026384-ejk9wjr1 28 15 apply apply VB cord-026384-ejk9wjr1 28 16 , , , cord-026384-ejk9wjr1 28 17 when when WRB cord-026384-ejk9wjr1 28 18 providing provide VBG cord-026384-ejk9wjr1 28 19 critical critical JJ cord-026384-ejk9wjr1 28 20 data datum NNS cord-026384-ejk9wjr1 28 21 to to IN cord-026384-ejk9wjr1 28 22 parents parent NNS cord-026384-ejk9wjr1 28 23 for for IN cord-026384-ejk9wjr1 28 24 informed informed JJ cord-026384-ejk9wjr1 28 25 decision decision NN cord-026384-ejk9wjr1 28 26 - - HYPH cord-026384-ejk9wjr1 28 27 making making NN cord-026384-ejk9wjr1 28 28 , , , cord-026384-ejk9wjr1 28 29 and and CC cord-026384-ejk9wjr1 28 30 when when WRB cord-026384-ejk9wjr1 28 31 matching match VBG cord-026384-ejk9wjr1 28 32 infants infant NNS cord-026384-ejk9wjr1 28 33 with with IN cord-026384-ejk9wjr1 28 34 outpatient outpatient NN cord-026384-ejk9wjr1 28 35 services service NNS cord-026384-ejk9wjr1 28 36 to to TO cord-026384-ejk9wjr1 28 37 best best RB cord-026384-ejk9wjr1 28 38 meet meet VB cord-026384-ejk9wjr1 28 39 their -PRON- PRP$ cord-026384-ejk9wjr1 28 40 needs need NNS cord-026384-ejk9wjr1 28 41 . . . cord-026384-ejk9wjr1 29 1 In in IN cord-026384-ejk9wjr1 29 2 addition addition NN cord-026384-ejk9wjr1 29 3 , , , cord-026384-ejk9wjr1 29 4 prediction prediction NN cord-026384-ejk9wjr1 29 5 models model NNS cord-026384-ejk9wjr1 29 6 are be VBP cord-026384-ejk9wjr1 29 7 useful useful JJ cord-026384-ejk9wjr1 29 8 in in IN cord-026384-ejk9wjr1 29 9 evaluating evaluate VBG cord-026384-ejk9wjr1 29 10 Neonatal Neonatal NNP cord-026384-ejk9wjr1 29 11 Intensive Intensive NNP cord-026384-ejk9wjr1 29 12 Care Care NNP cord-026384-ejk9wjr1 29 13 Unit Unit NNP cord-026384-ejk9wjr1 29 14 ( ( -LRB- cord-026384-ejk9wjr1 29 15 NICU NICU NNP cord-026384-ejk9wjr1 29 16 ) ) -RRB- cord-026384-ejk9wjr1 29 17 performance performance NN cord-026384-ejk9wjr1 29 18 and and CC cord-026384-ejk9wjr1 29 19 allowing allow VBG cord-026384-ejk9wjr1 29 20 for for IN cord-026384-ejk9wjr1 29 21 between between IN cord-026384-ejk9wjr1 29 22 - - HYPH cord-026384-ejk9wjr1 29 23 center center NN cord-026384-ejk9wjr1 29 24 comparisons comparison NNS cord-026384-ejk9wjr1 29 25 with with IN cord-026384-ejk9wjr1 29 26 proper proper JJ cord-026384-ejk9wjr1 29 27 adjustment adjustment NN cord-026384-ejk9wjr1 29 28 for for IN cord-026384-ejk9wjr1 29 29 the the DT cord-026384-ejk9wjr1 29 30 severity severity NN cord-026384-ejk9wjr1 29 31 of of IN cord-026384-ejk9wjr1 29 32 cases case NNS cord-026384-ejk9wjr1 29 33 being be VBG cord-026384-ejk9wjr1 29 34 treated treat VBN cord-026384-ejk9wjr1 29 35 . . . cord-026384-ejk9wjr1 30 1 11 11 CD cord-026384-ejk9wjr1 31 1 Numerous numerous JJ cord-026384-ejk9wjr1 31 2 prediction prediction NN cord-026384-ejk9wjr1 31 3 tools tool NNS cord-026384-ejk9wjr1 31 4 have have VBP cord-026384-ejk9wjr1 31 5 been be VBN cord-026384-ejk9wjr1 31 6 developed develop VBN cord-026384-ejk9wjr1 31 7 to to TO cord-026384-ejk9wjr1 31 8 quantify quantify VB cord-026384-ejk9wjr1 31 9 the the DT cord-026384-ejk9wjr1 31 10 risk risk NN cord-026384-ejk9wjr1 31 11 of of IN cord-026384-ejk9wjr1 31 12 death death NN cord-026384-ejk9wjr1 31 13 for for IN cord-026384-ejk9wjr1 31 14 preterm preterm JJ cord-026384-ejk9wjr1 31 15 neonates neonate NNS cord-026384-ejk9wjr1 31 16 in in IN cord-026384-ejk9wjr1 31 17 the the DT cord-026384-ejk9wjr1 31 18 NICU NICU NNP cord-026384-ejk9wjr1 31 19 setting setting NN cord-026384-ejk9wjr1 31 20 , , , cord-026384-ejk9wjr1 31 21 including include VBG cord-026384-ejk9wjr1 31 22 the the DT cord-026384-ejk9wjr1 31 23 Score score NN cord-026384-ejk9wjr1 31 24 for for IN cord-026384-ejk9wjr1 31 25 Neonatal Neonatal NNP cord-026384-ejk9wjr1 31 26 Acute acute JJ cord-026384-ejk9wjr1 31 27 Physiology Physiology NNP cord-026384-ejk9wjr1 31 28 ( ( -LRB- cord-026384-ejk9wjr1 31 29 SNAP snap VB cord-026384-ejk9wjr1 31 30 ) ) -RRB- cord-026384-ejk9wjr1 31 31 and and CC cord-026384-ejk9wjr1 31 32 the the DT cord-026384-ejk9wjr1 31 33 Clinical Clinical NNP cord-026384-ejk9wjr1 31 34 Risk Risk NNP cord-026384-ejk9wjr1 31 35 Index Index NNP cord-026384-ejk9wjr1 31 36 for for IN cord-026384-ejk9wjr1 31 37 Babies baby NNS cord-026384-ejk9wjr1 31 38 ( ( -LRB- cord-026384-ejk9wjr1 31 39 CRIB crib NN cord-026384-ejk9wjr1 31 40 ) ) -RRB- cord-026384-ejk9wjr1 31 41 . . . cord-026384-ejk9wjr1 32 1 12 12 CD cord-026384-ejk9wjr1 33 1 The the DT cord-026384-ejk9wjr1 33 2 National National NNP cord-026384-ejk9wjr1 33 3 Institute Institute NNP cord-026384-ejk9wjr1 33 4 of of IN cord-026384-ejk9wjr1 33 5 Child Child NNP cord-026384-ejk9wjr1 33 6 Health Health NNP cord-026384-ejk9wjr1 33 7 and and CC cord-026384-ejk9wjr1 33 8 Human Human NNP cord-026384-ejk9wjr1 33 9 Development Development NNP cord-026384-ejk9wjr1 33 10 ( ( -LRB- cord-026384-ejk9wjr1 33 11 NICHD NICHD NNP cord-026384-ejk9wjr1 33 12 ) ) -RRB- cord-026384-ejk9wjr1 33 13 risk risk NN cord-026384-ejk9wjr1 33 14 calculator calculator NN cord-026384-ejk9wjr1 33 15 , , , cord-026384-ejk9wjr1 33 16 predicting predict VBG cord-026384-ejk9wjr1 33 17 survival survival NN cord-026384-ejk9wjr1 33 18 with with IN cord-026384-ejk9wjr1 33 19 and and CC cord-026384-ejk9wjr1 33 20 without without IN cord-026384-ejk9wjr1 33 21 neurosensory neurosensory JJ cord-026384-ejk9wjr1 33 22 impairment impairment NN cord-026384-ejk9wjr1 33 23 , , , cord-026384-ejk9wjr1 33 24 is be VBZ cord-026384-ejk9wjr1 33 25 widely widely RB cord-026384-ejk9wjr1 33 26 used use VBN cord-026384-ejk9wjr1 33 27 to to TO cord-026384-ejk9wjr1 33 28 counsel counsel VB cord-026384-ejk9wjr1 33 29 families family NNS cord-026384-ejk9wjr1 33 30 in in IN cord-026384-ejk9wjr1 33 31 the the DT cord-026384-ejk9wjr1 33 32 setting setting NN cord-026384-ejk9wjr1 33 33 of of IN cord-026384-ejk9wjr1 33 34 threatened threaten VBN cord-026384-ejk9wjr1 33 35 delivery delivery NN cord-026384-ejk9wjr1 33 36 at at IN cord-026384-ejk9wjr1 33 37 the the DT cord-026384-ejk9wjr1 33 38 edges edge NNS cord-026384-ejk9wjr1 33 39 of of IN cord-026384-ejk9wjr1 33 40 viability viability NN cord-026384-ejk9wjr1 33 41 . . . cord-026384-ejk9wjr1 34 1 13 13 CD cord-026384-ejk9wjr1 35 1 Furthermore furthermore RB cord-026384-ejk9wjr1 35 2 , , , cord-026384-ejk9wjr1 35 3 there there EX cord-026384-ejk9wjr1 35 4 are be VBP cord-026384-ejk9wjr1 35 5 numerous numerous JJ cord-026384-ejk9wjr1 35 6 other other JJ cord-026384-ejk9wjr1 35 7 models model NNS cord-026384-ejk9wjr1 35 8 that that WDT cord-026384-ejk9wjr1 35 9 use use VBP cord-026384-ejk9wjr1 35 10 clinical clinical JJ cord-026384-ejk9wjr1 35 11 data datum NNS cord-026384-ejk9wjr1 35 12 from from IN cord-026384-ejk9wjr1 35 13 the the DT cord-026384-ejk9wjr1 35 14 NICU NICU NNP cord-026384-ejk9wjr1 35 15 stay stay NN cord-026384-ejk9wjr1 35 16 to to TO cord-026384-ejk9wjr1 35 17 predict predict VB cord-026384-ejk9wjr1 35 18 risk risk NN cord-026384-ejk9wjr1 35 19 for for IN cord-026384-ejk9wjr1 35 20 poor poor JJ cord-026384-ejk9wjr1 35 21 functional functional JJ cord-026384-ejk9wjr1 35 22 outcomes outcome NNS cord-026384-ejk9wjr1 35 23 in in IN cord-026384-ejk9wjr1 35 24 infancy infancy NN cord-026384-ejk9wjr1 35 25 and and CC cord-026384-ejk9wjr1 35 26 school school NN cord-026384-ejk9wjr1 35 27 age age NN cord-026384-ejk9wjr1 35 28 . . . cord-026384-ejk9wjr1 36 1 14 14 CD cord-026384-ejk9wjr1 36 2 , , , cord-026384-ejk9wjr1 36 3 15 15 CD cord-026384-ejk9wjr1 36 4 While while IN cord-026384-ejk9wjr1 36 5 several several JJ cord-026384-ejk9wjr1 36 6 studies study NNS cord-026384-ejk9wjr1 36 7 have have VBP cord-026384-ejk9wjr1 36 8 categorized categorize VBN cord-026384-ejk9wjr1 36 9 and and CC cord-026384-ejk9wjr1 36 10 evaluated evaluate VBN cord-026384-ejk9wjr1 36 11 the the DT cord-026384-ejk9wjr1 36 12 risk risk NN cord-026384-ejk9wjr1 36 13 prediction prediction NN cord-026384-ejk9wjr1 36 14 models model NNS cord-026384-ejk9wjr1 36 15 developed develop VBD cord-026384-ejk9wjr1 36 16 and and CC cord-026384-ejk9wjr1 36 17 validated validate VBN cord-026384-ejk9wjr1 36 18 in in IN cord-026384-ejk9wjr1 36 19 recent recent JJ cord-026384-ejk9wjr1 36 20 decades decade NNS cord-026384-ejk9wjr1 36 21 for for IN cord-026384-ejk9wjr1 36 22 mortality mortality NN cord-026384-ejk9wjr1 36 23 , , , cord-026384-ejk9wjr1 36 24 12 12 CD cord-026384-ejk9wjr1 36 25 , , , cord-026384-ejk9wjr1 36 26 16 16 CD cord-026384-ejk9wjr1 36 27 no no DT cord-026384-ejk9wjr1 36 28 studies study NNS cord-026384-ejk9wjr1 36 29 have have VBP cord-026384-ejk9wjr1 36 30 compared compare VBN cord-026384-ejk9wjr1 36 31 and and CC cord-026384-ejk9wjr1 36 32 contrasted contrast VBN cord-026384-ejk9wjr1 36 33 risk risk NN cord-026384-ejk9wjr1 36 34 prediction prediction NN cord-026384-ejk9wjr1 36 35 models model NNS cord-026384-ejk9wjr1 36 36 for for IN cord-026384-ejk9wjr1 36 37 non non JJ cord-026384-ejk9wjr1 36 38 - - JJ cord-026384-ejk9wjr1 36 39 mortality mortality JJ cord-026384-ejk9wjr1 36 40 outcomes outcome NNS cord-026384-ejk9wjr1 36 41 . . . cord-026384-ejk9wjr1 37 1 Recently recently RB cord-026384-ejk9wjr1 37 2 , , , cord-026384-ejk9wjr1 37 3 Linsell Linsell NNP cord-026384-ejk9wjr1 37 4 et et FW cord-026384-ejk9wjr1 37 5 al al NNP cord-026384-ejk9wjr1 37 6 . . . cord-026384-ejk9wjr1 38 1 17 17 CD cord-026384-ejk9wjr1 38 2 published publish VBD cord-026384-ejk9wjr1 38 3 a a DT cord-026384-ejk9wjr1 38 4 systematic systematic JJ cord-026384-ejk9wjr1 38 5 review review NN cord-026384-ejk9wjr1 38 6 of of IN cord-026384-ejk9wjr1 38 7 risk risk NN cord-026384-ejk9wjr1 38 8 factor factor NN cord-026384-ejk9wjr1 38 9 models model NNS cord-026384-ejk9wjr1 38 10 for for IN cord-026384-ejk9wjr1 38 11 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 38 12 outcomes outcome NNS cord-026384-ejk9wjr1 38 13 in in IN cord-026384-ejk9wjr1 38 14 children child NNS cord-026384-ejk9wjr1 38 15 born bear VBD cord-026384-ejk9wjr1 38 16 very very RB cord-026384-ejk9wjr1 38 17 preterm preterm NNS cord-026384-ejk9wjr1 38 18 or or CC cord-026384-ejk9wjr1 38 19 very very RB cord-026384-ejk9wjr1 38 20 low low JJ cord-026384-ejk9wjr1 38 21 birth birth NN cord-026384-ejk9wjr1 38 22 weight weight NN cord-026384-ejk9wjr1 38 23 ( ( -LRB- cord-026384-ejk9wjr1 38 24 VLBW VLBW NNP cord-026384-ejk9wjr1 38 25 ) ) -RRB- cord-026384-ejk9wjr1 38 26 . . . cord-026384-ejk9wjr1 39 1 However however RB cord-026384-ejk9wjr1 39 2 , , , cord-026384-ejk9wjr1 39 3 this this DT cord-026384-ejk9wjr1 39 4 review review NN cord-026384-ejk9wjr1 39 5 focused focus VBD cord-026384-ejk9wjr1 39 6 primarily primarily RB cord-026384-ejk9wjr1 39 7 on on IN cord-026384-ejk9wjr1 39 8 overall overall JJ cord-026384-ejk9wjr1 39 9 trends trend NNS cord-026384-ejk9wjr1 39 10 in in IN cord-026384-ejk9wjr1 39 11 model model NN cord-026384-ejk9wjr1 39 12 development development NN cord-026384-ejk9wjr1 39 13 and and CC cord-026384-ejk9wjr1 39 14 validation validation NN cord-026384-ejk9wjr1 39 15 rather rather RB cord-026384-ejk9wjr1 39 16 than than IN cord-026384-ejk9wjr1 39 17 a a DT cord-026384-ejk9wjr1 39 18 detailed detailed JJ cord-026384-ejk9wjr1 39 19 consideration consideration NN cord-026384-ejk9wjr1 39 20 of of IN cord-026384-ejk9wjr1 39 21 individual individual JJ cord-026384-ejk9wjr1 39 22 models model NNS cord-026384-ejk9wjr1 39 23 . . . cord-026384-ejk9wjr1 40 1 In in IN cord-026384-ejk9wjr1 40 2 this this DT cord-026384-ejk9wjr1 40 3 article article NN cord-026384-ejk9wjr1 40 4 , , , cord-026384-ejk9wjr1 40 5 we -PRON- PRP cord-026384-ejk9wjr1 40 6 conduct conduct VBP cord-026384-ejk9wjr1 40 7 an an DT cord-026384-ejk9wjr1 40 8 in in IN cord-026384-ejk9wjr1 40 9 - - HYPH cord-026384-ejk9wjr1 40 10 depth depth NN cord-026384-ejk9wjr1 40 11 , , , cord-026384-ejk9wjr1 40 12 narrative narrative NN cord-026384-ejk9wjr1 40 13 review review NN cord-026384-ejk9wjr1 40 14 of of IN cord-026384-ejk9wjr1 40 15 the the DT cord-026384-ejk9wjr1 40 16 current current JJ cord-026384-ejk9wjr1 40 17 risk risk NN cord-026384-ejk9wjr1 40 18 models model NNS cord-026384-ejk9wjr1 40 19 available available JJ cord-026384-ejk9wjr1 40 20 for for IN cord-026384-ejk9wjr1 40 21 predicting predict VBG cord-026384-ejk9wjr1 40 22 the the DT cord-026384-ejk9wjr1 40 23 functional functional JJ cord-026384-ejk9wjr1 40 24 outcomes outcome NNS cord-026384-ejk9wjr1 40 25 of of IN cord-026384-ejk9wjr1 40 26 preterm preterm JJ cord-026384-ejk9wjr1 40 27 neonates neonate NNS cord-026384-ejk9wjr1 40 28 , , , cord-026384-ejk9wjr1 40 29 evaluating evaluate VBG cord-026384-ejk9wjr1 40 30 their -PRON- PRP$ cord-026384-ejk9wjr1 40 31 relative relative JJ cord-026384-ejk9wjr1 40 32 strengths strength NNS cord-026384-ejk9wjr1 40 33 and and CC cord-026384-ejk9wjr1 40 34 weaknesses weakness NNS cord-026384-ejk9wjr1 40 35 in in IN cord-026384-ejk9wjr1 40 36 variable variable NN cord-026384-ejk9wjr1 40 37 and and CC cord-026384-ejk9wjr1 40 38 outcome outcome NN cord-026384-ejk9wjr1 40 39 selection selection NN cord-026384-ejk9wjr1 40 40 , , , cord-026384-ejk9wjr1 40 41 and and CC cord-026384-ejk9wjr1 40 42 considering consider VBG cord-026384-ejk9wjr1 40 43 how how WRB cord-026384-ejk9wjr1 40 44 risk risk NN cord-026384-ejk9wjr1 40 45 model model NN cord-026384-ejk9wjr1 40 46 development development NN cord-026384-ejk9wjr1 40 47 and and CC cord-026384-ejk9wjr1 40 48 validation validation NN cord-026384-ejk9wjr1 40 49 can can MD cord-026384-ejk9wjr1 40 50 be be VB cord-026384-ejk9wjr1 40 51 improved improve VBN cord-026384-ejk9wjr1 40 52 in in IN cord-026384-ejk9wjr1 40 53 the the DT cord-026384-ejk9wjr1 40 54 future future NN cord-026384-ejk9wjr1 40 55 . . . cord-026384-ejk9wjr1 41 1 Towards towards IN cord-026384-ejk9wjr1 41 2 this this DT cord-026384-ejk9wjr1 41 3 , , , cord-026384-ejk9wjr1 41 4 we -PRON- PRP cord-026384-ejk9wjr1 41 5 first first RB cord-026384-ejk9wjr1 41 6 provide provide VBP cord-026384-ejk9wjr1 41 7 an an DT cord-026384-ejk9wjr1 41 8 overview overview NN cord-026384-ejk9wjr1 41 9 of of IN cord-026384-ejk9wjr1 41 10 the the DT cord-026384-ejk9wjr1 41 11 different different JJ cord-026384-ejk9wjr1 41 12 risk risk NN cord-026384-ejk9wjr1 41 13 models model NNS cord-026384-ejk9wjr1 41 14 developed develop VBN cord-026384-ejk9wjr1 41 15 since since IN cord-026384-ejk9wjr1 41 16 1990 1990 CD cord-026384-ejk9wjr1 41 17 . . . cord-026384-ejk9wjr1 42 1 We -PRON- PRP cord-026384-ejk9wjr1 42 2 then then RB cord-026384-ejk9wjr1 42 3 frame frame VBP cord-026384-ejk9wjr1 42 4 our -PRON- PRP$ cord-026384-ejk9wjr1 42 5 review review NN cord-026384-ejk9wjr1 42 6 of of IN cord-026384-ejk9wjr1 42 7 these these DT cord-026384-ejk9wjr1 42 8 models model NNS cord-026384-ejk9wjr1 42 9 in in IN cord-026384-ejk9wjr1 42 10 terms term NNS cord-026384-ejk9wjr1 42 11 of of IN cord-026384-ejk9wjr1 42 12 the the DT cord-026384-ejk9wjr1 42 13 outcomes outcome NNS cord-026384-ejk9wjr1 42 14 predicted predict VBN cord-026384-ejk9wjr1 42 15 , , , cord-026384-ejk9wjr1 42 16 the the DT cord-026384-ejk9wjr1 42 17 range range NN cord-026384-ejk9wjr1 42 18 of of IN cord-026384-ejk9wjr1 42 19 predictors predictor NNS cord-026384-ejk9wjr1 42 20 considered consider VBN cord-026384-ejk9wjr1 42 21 , , , cord-026384-ejk9wjr1 42 22 and and CC cord-026384-ejk9wjr1 42 23 the the DT cord-026384-ejk9wjr1 42 24 statistical statistical JJ cord-026384-ejk9wjr1 42 25 methods method NNS cord-026384-ejk9wjr1 42 26 used use VBN cord-026384-ejk9wjr1 42 27 to to TO cord-026384-ejk9wjr1 42 28 select select VB cord-026384-ejk9wjr1 42 29 the the DT cord-026384-ejk9wjr1 42 30 variables variable NNS cord-026384-ejk9wjr1 42 31 included include VBN cord-026384-ejk9wjr1 42 32 in in IN cord-026384-ejk9wjr1 42 33 the the DT cord-026384-ejk9wjr1 42 34 final final JJ cord-026384-ejk9wjr1 42 35 model model NN cord-026384-ejk9wjr1 42 36 , , , cord-026384-ejk9wjr1 42 37 as as RB cord-026384-ejk9wjr1 42 38 well well RB cord-026384-ejk9wjr1 42 39 as as IN cord-026384-ejk9wjr1 42 40 to to TO cord-026384-ejk9wjr1 42 41 assess assess VB cord-026384-ejk9wjr1 42 42 the the DT cord-026384-ejk9wjr1 42 43 predictive predictive JJ cord-026384-ejk9wjr1 42 44 performance performance NN cord-026384-ejk9wjr1 42 45 of of IN cord-026384-ejk9wjr1 42 46 the the DT cord-026384-ejk9wjr1 42 47 model model NN cord-026384-ejk9wjr1 42 48 . . . cord-026384-ejk9wjr1 43 1 Finally finally RB cord-026384-ejk9wjr1 43 2 , , , cord-026384-ejk9wjr1 43 3 the the DT cord-026384-ejk9wjr1 43 4 ethical ethical JJ cord-026384-ejk9wjr1 43 5 implications implication NNS cord-026384-ejk9wjr1 43 6 of of IN cord-026384-ejk9wjr1 43 7 integrating integrate VBG cord-026384-ejk9wjr1 43 8 risk risk NN cord-026384-ejk9wjr1 43 9 stratification stratification NN cord-026384-ejk9wjr1 43 10 into into IN cord-026384-ejk9wjr1 43 11 standard standard JJ cord-026384-ejk9wjr1 43 12 clinical clinical JJ cord-026384-ejk9wjr1 43 13 care care NN cord-026384-ejk9wjr1 43 14 for for IN cord-026384-ejk9wjr1 43 15 preterm preterm JJ cord-026384-ejk9wjr1 43 16 neonates neonate NNS cord-026384-ejk9wjr1 43 17 are be VBP cord-026384-ejk9wjr1 43 18 considered consider VBN cord-026384-ejk9wjr1 43 19 . . . cord-026384-ejk9wjr1 44 1 We -PRON- PRP cord-026384-ejk9wjr1 44 2 conducted conduct VBD cord-026384-ejk9wjr1 44 3 a a DT cord-026384-ejk9wjr1 44 4 manual manual JJ cord-026384-ejk9wjr1 44 5 search search NN cord-026384-ejk9wjr1 44 6 for for IN cord-026384-ejk9wjr1 44 7 relevant relevant JJ cord-026384-ejk9wjr1 44 8 literature literature NN cord-026384-ejk9wjr1 44 9 via via IN cord-026384-ejk9wjr1 44 10 PubMed PubMed NNP cord-026384-ejk9wjr1 44 11 , , , cord-026384-ejk9wjr1 44 12 entering enter VBG cord-026384-ejk9wjr1 44 13 combinations combination NNS cord-026384-ejk9wjr1 44 14 of of IN cord-026384-ejk9wjr1 44 15 key key JJ cord-026384-ejk9wjr1 44 16 terms term NNS cord-026384-ejk9wjr1 44 17 synonymous synonymous JJ cord-026384-ejk9wjr1 44 18 with with IN cord-026384-ejk9wjr1 44 19 " " `` cord-026384-ejk9wjr1 44 20 prediction prediction NN cord-026384-ejk9wjr1 44 21 tool tool NN cord-026384-ejk9wjr1 44 22 , , , cord-026384-ejk9wjr1 44 23 " " '' cord-026384-ejk9wjr1 44 24 " " `` cord-026384-ejk9wjr1 44 25 preterm preterm NNS cord-026384-ejk9wjr1 44 26 , , , cord-026384-ejk9wjr1 44 27 " " '' cord-026384-ejk9wjr1 44 28 and and CC cord-026384-ejk9wjr1 44 29 " " `` cord-026384-ejk9wjr1 44 30 functional functional JJ cord-026384-ejk9wjr1 44 31 outcome outcome NN cord-026384-ejk9wjr1 44 32 " " '' cord-026384-ejk9wjr1 44 33 and and CC cord-026384-ejk9wjr1 44 34 reading read VBG cord-026384-ejk9wjr1 44 35 the the DT cord-026384-ejk9wjr1 44 36 abstracts abstract NNS cord-026384-ejk9wjr1 44 37 of of IN cord-026384-ejk9wjr1 44 38 resulting result VBG cord-026384-ejk9wjr1 44 39 studies study NNS cord-026384-ejk9wjr1 44 40 ( ( -LRB- cord-026384-ejk9wjr1 44 41 Table table NN cord-026384-ejk9wjr1 44 42 1 1 CD cord-026384-ejk9wjr1 44 43 ) ) -RRB- cord-026384-ejk9wjr1 44 44 . . . cord-026384-ejk9wjr1 45 1 Studies study NNS cord-026384-ejk9wjr1 45 2 with with IN cord-026384-ejk9wjr1 45 3 abstracts abstract NNS cord-026384-ejk9wjr1 45 4 that that WDT cord-026384-ejk9wjr1 45 5 appeared appear VBD cord-026384-ejk9wjr1 45 6 related related JJ cord-026384-ejk9wjr1 45 7 to to IN cord-026384-ejk9wjr1 45 8 our -PRON- PRP$ cord-026384-ejk9wjr1 45 9 review review NN cord-026384-ejk9wjr1 45 10 were be VBD cord-026384-ejk9wjr1 45 11 then then RB cord-026384-ejk9wjr1 45 12 read read VBN cord-026384-ejk9wjr1 45 13 in in IN cord-026384-ejk9wjr1 45 14 full full JJ cord-026384-ejk9wjr1 45 15 to to TO cord-026384-ejk9wjr1 45 16 identify identify VB cord-026384-ejk9wjr1 45 17 prediction prediction NN cord-026384-ejk9wjr1 45 18 models model NNS cord-026384-ejk9wjr1 45 19 that that WDT cord-026384-ejk9wjr1 45 20 were be VBD cord-026384-ejk9wjr1 45 21 eligible eligible JJ cord-026384-ejk9wjr1 45 22 for for IN cord-026384-ejk9wjr1 45 23 inclusion inclusion NN cord-026384-ejk9wjr1 45 24 . . . cord-026384-ejk9wjr1 46 1 Reference reference NN cord-026384-ejk9wjr1 46 2 lists list NNS cord-026384-ejk9wjr1 46 3 of of IN cord-026384-ejk9wjr1 46 4 included include VBN cord-026384-ejk9wjr1 46 5 studies study NNS cord-026384-ejk9wjr1 46 6 were be VBD cord-026384-ejk9wjr1 46 7 also also RB cord-026384-ejk9wjr1 46 8 reviewed review VBN cord-026384-ejk9wjr1 46 9 , , , cord-026384-ejk9wjr1 46 10 as as IN cord-026384-ejk9wjr1 46 11 were be VBD cord-026384-ejk9wjr1 46 12 articles article NNS cord-026384-ejk9wjr1 46 13 that that WDT cord-026384-ejk9wjr1 46 14 later later RB cord-026384-ejk9wjr1 46 15 cited cite VBD cord-026384-ejk9wjr1 46 16 these these DT cord-026384-ejk9wjr1 46 17 original original JJ cord-026384-ejk9wjr1 46 18 studies study NNS cord-026384-ejk9wjr1 46 19 . . . cord-026384-ejk9wjr1 47 1 Prediction prediction NN cord-026384-ejk9wjr1 47 2 tools tool NNS cord-026384-ejk9wjr1 47 3 were be VBD cord-026384-ejk9wjr1 47 4 defined define VBN cord-026384-ejk9wjr1 47 5 as as IN cord-026384-ejk9wjr1 47 6 multivariable multivariable JJ cord-026384-ejk9wjr1 47 7 risk risk NN cord-026384-ejk9wjr1 47 8 factor factor NN cord-026384-ejk9wjr1 47 9 analyses analysis NNS cord-026384-ejk9wjr1 47 10 ( ( -LRB- cord-026384-ejk9wjr1 47 11 > > NFP cord-026384-ejk9wjr1 47 12 2 2 CD cord-026384-ejk9wjr1 47 13 variables variable NNS cord-026384-ejk9wjr1 47 14 ) ) -RRB- cord-026384-ejk9wjr1 47 15 aiming aim VBG cord-026384-ejk9wjr1 47 16 to to TO cord-026384-ejk9wjr1 47 17 predict predict VB cord-026384-ejk9wjr1 47 18 the the DT cord-026384-ejk9wjr1 47 19 probability probability NN cord-026384-ejk9wjr1 47 20 of of IN cord-026384-ejk9wjr1 47 21 developing develop VBG cord-026384-ejk9wjr1 47 22 functional functional JJ cord-026384-ejk9wjr1 47 23 outcomes outcome NNS cord-026384-ejk9wjr1 47 24 beyond beyond IN cord-026384-ejk9wjr1 47 25 6 6 CD cord-026384-ejk9wjr1 47 26 months month NNS cord-026384-ejk9wjr1 47 27 corrected correct VBN cord-026384-ejk9wjr1 47 28 age age NN cord-026384-ejk9wjr1 47 29 . . . cord-026384-ejk9wjr1 48 1 Models model NNS cord-026384-ejk9wjr1 48 2 that that WDT cord-026384-ejk9wjr1 48 3 solely solely RB cord-026384-ejk9wjr1 48 4 investigated investigate VBN cord-026384-ejk9wjr1 48 5 associations association NNS cord-026384-ejk9wjr1 48 6 between between IN cord-026384-ejk9wjr1 48 7 individual individual JJ cord-026384-ejk9wjr1 48 8 risk risk NN cord-026384-ejk9wjr1 48 9 factors factor NNS cord-026384-ejk9wjr1 48 10 and and CC cord-026384-ejk9wjr1 48 11 outcomes outcome NNS cord-026384-ejk9wjr1 48 12 were be VBD cord-026384-ejk9wjr1 48 13 excluded exclude VBN cord-026384-ejk9wjr1 48 14 , , , cord-026384-ejk9wjr1 48 15 as as IN cord-026384-ejk9wjr1 48 16 were be VBD cord-026384-ejk9wjr1 48 17 models model NNS cord-026384-ejk9wjr1 48 18 that that WDT cord-026384-ejk9wjr1 48 19 were be VBD cord-026384-ejk9wjr1 48 20 not not RB cord-026384-ejk9wjr1 48 21 evaluated evaluate VBN cord-026384-ejk9wjr1 48 22 for for IN cord-026384-ejk9wjr1 48 23 predictive predictive JJ cord-026384-ejk9wjr1 48 24 ability ability NN cord-026384-ejk9wjr1 48 25 in in IN cord-026384-ejk9wjr1 48 26 terms term NNS cord-026384-ejk9wjr1 48 27 of of IN cord-026384-ejk9wjr1 48 28 either either CC cord-026384-ejk9wjr1 48 29 a a DT cord-026384-ejk9wjr1 48 30 validation validation NN cord-026384-ejk9wjr1 48 31 study study NN cord-026384-ejk9wjr1 48 32 or or CC cord-026384-ejk9wjr1 48 33 an an DT cord-026384-ejk9wjr1 48 34 assessment assessment NN cord-026384-ejk9wjr1 48 35 for for IN cord-026384-ejk9wjr1 48 36 performance performance NN cord-026384-ejk9wjr1 48 37 , , , cord-026384-ejk9wjr1 48 38 discrimination discrimination NN cord-026384-ejk9wjr1 48 39 , , , cord-026384-ejk9wjr1 48 40 or or CC cord-026384-ejk9wjr1 48 41 calibration calibration NN cord-026384-ejk9wjr1 48 42 . . . cord-026384-ejk9wjr1 49 1 Tests test NNS cord-026384-ejk9wjr1 49 2 used use VBD cord-026384-ejk9wjr1 49 3 to to TO cord-026384-ejk9wjr1 49 4 evaluate evaluate VB cord-026384-ejk9wjr1 49 5 a a DT cord-026384-ejk9wjr1 49 6 model model NN cord-026384-ejk9wjr1 49 7 's 's POS cord-026384-ejk9wjr1 49 8 overall overall JJ cord-026384-ejk9wjr1 49 9 performance performance NN cord-026384-ejk9wjr1 49 10 were be VBD cord-026384-ejk9wjr1 49 11 R R NNP cord-026384-ejk9wjr1 49 12 2 2 CD cord-026384-ejk9wjr1 49 13 , , , cord-026384-ejk9wjr1 49 14 adjusted adjust VBN cord-026384-ejk9wjr1 49 15 R R NNP cord-026384-ejk9wjr1 49 16 2 2 CD cord-026384-ejk9wjr1 49 17 , , , cord-026384-ejk9wjr1 49 18 and and CC cord-026384-ejk9wjr1 49 19 the the DT cord-026384-ejk9wjr1 49 20 Brier Brier NNP cord-026384-ejk9wjr1 49 21 score score NN cord-026384-ejk9wjr1 49 22 . . . cord-026384-ejk9wjr1 50 1 The the DT cord-026384-ejk9wjr1 50 2 use use NN cord-026384-ejk9wjr1 50 3 of of IN cord-026384-ejk9wjr1 50 4 a a DT cord-026384-ejk9wjr1 50 5 receiver receiver NN cord-026384-ejk9wjr1 50 6 operating operating NN cord-026384-ejk9wjr1 50 7 characteristic characteristic NN cord-026384-ejk9wjr1 50 8 ( ( -LRB- cord-026384-ejk9wjr1 50 9 ROC ROC NNP cord-026384-ejk9wjr1 50 10 ) ) -RRB- cord-026384-ejk9wjr1 50 11 curve curve NN cord-026384-ejk9wjr1 50 12 or or CC cord-026384-ejk9wjr1 50 13 a a DT cord-026384-ejk9wjr1 50 14 C c NN cord-026384-ejk9wjr1 50 15 - - HYPH cord-026384-ejk9wjr1 50 16 index index NN cord-026384-ejk9wjr1 50 17 evaluated evaluate VBD cord-026384-ejk9wjr1 50 18 a a DT cord-026384-ejk9wjr1 50 19 model model NN cord-026384-ejk9wjr1 50 20 's 's POS cord-026384-ejk9wjr1 50 21 discrimination discrimination NN cord-026384-ejk9wjr1 50 22 , , , cord-026384-ejk9wjr1 50 23 and and CC cord-026384-ejk9wjr1 50 24 the the DT cord-026384-ejk9wjr1 50 25 Hosmer Hosmer NNP cord-026384-ejk9wjr1 50 26 - - HYPH cord-026384-ejk9wjr1 50 27 Lemeshow Lemeshow NNP cord-026384-ejk9wjr1 50 28 test test NN cord-026384-ejk9wjr1 50 29 was be VBD cord-026384-ejk9wjr1 50 30 considered consider VBN cord-026384-ejk9wjr1 50 31 to to TO cord-026384-ejk9wjr1 50 32 evaluate evaluate VB cord-026384-ejk9wjr1 50 33 a a DT cord-026384-ejk9wjr1 50 34 model model NN cord-026384-ejk9wjr1 50 35 's 's POS cord-026384-ejk9wjr1 50 36 calibration calibration NN cord-026384-ejk9wjr1 50 37 . . . cord-026384-ejk9wjr1 51 1 18 18 CD cord-026384-ejk9wjr1 52 1 Preterm Preterm NNP cord-026384-ejk9wjr1 52 2 neonates neonate NNS cord-026384-ejk9wjr1 52 3 were be VBD cord-026384-ejk9wjr1 52 4 defined define VBN cord-026384-ejk9wjr1 52 5 as as IN cord-026384-ejk9wjr1 52 6 < < NNP cord-026384-ejk9wjr1 52 7 37 37 CD cord-026384-ejk9wjr1 52 8 weeks week NNS cord-026384-ejk9wjr1 52 9 of of IN cord-026384-ejk9wjr1 52 10 completed complete VBN cord-026384-ejk9wjr1 52 11 gestational gestational JJ cord-026384-ejk9wjr1 52 12 age age NN cord-026384-ejk9wjr1 52 13 . . . cord-026384-ejk9wjr1 53 1 Models model NNS cord-026384-ejk9wjr1 53 2 with with IN cord-026384-ejk9wjr1 53 3 VLBW VLBW NNP cord-026384-ejk9wjr1 53 4 neonates neonate NNS cord-026384-ejk9wjr1 54 1 < < NNP cord-026384-ejk9wjr1 54 2 1500 1500 CD cord-026384-ejk9wjr1 54 3 g g NN cord-026384-ejk9wjr1 54 4 were be VBD cord-026384-ejk9wjr1 54 5 also also RB cord-026384-ejk9wjr1 54 6 included include VBN cord-026384-ejk9wjr1 54 7 , , , cord-026384-ejk9wjr1 54 8 since since IN cord-026384-ejk9wjr1 54 9 in in IN cord-026384-ejk9wjr1 54 10 the the DT cord-026384-ejk9wjr1 54 11 past past JJ cord-026384-ejk9wjr1 54 12 birth birth NN cord-026384-ejk9wjr1 54 13 weight weight NN cord-026384-ejk9wjr1 54 14 served serve VBD cord-026384-ejk9wjr1 54 15 as as IN cord-026384-ejk9wjr1 54 16 a a DT cord-026384-ejk9wjr1 54 17 substitute substitute NN cord-026384-ejk9wjr1 54 18 for for IN cord-026384-ejk9wjr1 54 19 measuring measure VBG cord-026384-ejk9wjr1 54 20 prematurity prematurity NN cord-026384-ejk9wjr1 54 21 when when WRB cord-026384-ejk9wjr1 54 22 gestational gestational JJ cord-026384-ejk9wjr1 54 23 age age NN cord-026384-ejk9wjr1 54 24 could could MD cord-026384-ejk9wjr1 54 25 not not RB cord-026384-ejk9wjr1 54 26 be be VB cord-026384-ejk9wjr1 54 27 accurately accurately RB cord-026384-ejk9wjr1 54 28 determined determine VBN cord-026384-ejk9wjr1 54 29 . . . cord-026384-ejk9wjr1 55 1 Models model NNS cord-026384-ejk9wjr1 55 2 were be VBD cord-026384-ejk9wjr1 55 3 excluded exclude VBN cord-026384-ejk9wjr1 55 4 if if IN cord-026384-ejk9wjr1 55 5 they -PRON- PRP cord-026384-ejk9wjr1 55 6 used use VBD cord-026384-ejk9wjr1 55 7 a a DT cord-026384-ejk9wjr1 55 8 cohort cohort NN cord-026384-ejk9wjr1 55 9 entirely entirely RB cord-026384-ejk9wjr1 55 10 composed compose VBN cord-026384-ejk9wjr1 55 11 of of IN cord-026384-ejk9wjr1 55 12 infants infant NNS cord-026384-ejk9wjr1 55 13 born bear VBN cord-026384-ejk9wjr1 55 14 prior prior RB cord-026384-ejk9wjr1 55 15 to to IN cord-026384-ejk9wjr1 55 16 1 1 CD cord-026384-ejk9wjr1 55 17 January January NNP cord-026384-ejk9wjr1 55 18 1990 1990 CD cord-026384-ejk9wjr1 55 19 ; ; : cord-026384-ejk9wjr1 55 20 those those DT cord-026384-ejk9wjr1 55 21 born bear VBN cord-026384-ejk9wjr1 55 22 after after IN cord-026384-ejk9wjr1 55 23 1990 1990 CD cord-026384-ejk9wjr1 55 24 were be VBD cord-026384-ejk9wjr1 55 25 likely likely JJ cord-026384-ejk9wjr1 55 26 to to TO cord-026384-ejk9wjr1 55 27 have have VB cord-026384-ejk9wjr1 55 28 had have VBN cord-026384-ejk9wjr1 55 29 surfactant surfactant NN cord-026384-ejk9wjr1 55 30 therapy therapy NN cord-026384-ejk9wjr1 55 31 available available JJ cord-026384-ejk9wjr1 55 32 in in IN cord-026384-ejk9wjr1 55 33 the the DT cord-026384-ejk9wjr1 55 34 event event NN cord-026384-ejk9wjr1 55 35 of of IN cord-026384-ejk9wjr1 55 36 respiratory respiratory JJ cord-026384-ejk9wjr1 55 37 distress distress NN cord-026384-ejk9wjr1 55 38 syndrome syndrome NN cord-026384-ejk9wjr1 55 39 , , , cord-026384-ejk9wjr1 55 40 which which WDT cord-026384-ejk9wjr1 55 41 significantly significantly RB cord-026384-ejk9wjr1 55 42 reduced reduce VBD cord-026384-ejk9wjr1 55 43 the the DT cord-026384-ejk9wjr1 55 44 morbidity morbidity NN cord-026384-ejk9wjr1 55 45 and and CC cord-026384-ejk9wjr1 55 46 mortality mortality NN cord-026384-ejk9wjr1 55 47 rates rate NNS cord-026384-ejk9wjr1 55 48 among among IN cord-026384-ejk9wjr1 55 49 preterm preterm JJ cord-026384-ejk9wjr1 55 50 neonates neonate NNS cord-026384-ejk9wjr1 55 51 nationwide nationwide JJ cord-026384-ejk9wjr1 55 52 . . . cord-026384-ejk9wjr1 56 1 19 19 CD cord-026384-ejk9wjr1 56 2 , , , cord-026384-ejk9wjr1 56 3 20 20 CD cord-026384-ejk9wjr1 56 4 Models model NNS cord-026384-ejk9wjr1 56 5 were be VBD cord-026384-ejk9wjr1 56 6 also also RB cord-026384-ejk9wjr1 56 7 excluded exclude VBN cord-026384-ejk9wjr1 56 8 if if IN cord-026384-ejk9wjr1 56 9 they -PRON- PRP cord-026384-ejk9wjr1 56 10 limited limit VBD cord-026384-ejk9wjr1 56 11 their -PRON- PRP$ cord-026384-ejk9wjr1 56 12 prediction prediction NN cord-026384-ejk9wjr1 56 13 to to IN cord-026384-ejk9wjr1 56 14 the the DT cord-026384-ejk9wjr1 56 15 outcome outcome NN cord-026384-ejk9wjr1 56 16 of of IN cord-026384-ejk9wjr1 56 17 survival survival NN cord-026384-ejk9wjr1 56 18 , , , cord-026384-ejk9wjr1 56 19 if if IN cord-026384-ejk9wjr1 56 20 they -PRON- PRP cord-026384-ejk9wjr1 56 21 incorporated incorporate VBD cord-026384-ejk9wjr1 56 22 variables variable NNS cord-026384-ejk9wjr1 56 23 measured measure VBN cord-026384-ejk9wjr1 56 24 after after IN cord-026384-ejk9wjr1 56 25 initial initial JJ cord-026384-ejk9wjr1 56 26 NICU NICU NNP cord-026384-ejk9wjr1 56 27 discharge discharge NN cord-026384-ejk9wjr1 56 28 , , , cord-026384-ejk9wjr1 56 29 or or CC cord-026384-ejk9wjr1 56 30 if if IN cord-026384-ejk9wjr1 56 31 they -PRON- PRP cord-026384-ejk9wjr1 56 32 included include VBD cord-026384-ejk9wjr1 56 33 subjects subject NNS cord-026384-ejk9wjr1 56 34 who who WP cord-026384-ejk9wjr1 56 35 were be VBD cord-026384-ejk9wjr1 56 36 not not RB cord-026384-ejk9wjr1 56 37 necessarily necessarily RB cord-026384-ejk9wjr1 56 38 transferred transfer VBN cord-026384-ejk9wjr1 56 39 to to IN cord-026384-ejk9wjr1 56 40 a a DT cord-026384-ejk9wjr1 56 41 NICU NICU NNP cord-026384-ejk9wjr1 56 42 for for IN cord-026384-ejk9wjr1 56 43 further further JJ cord-026384-ejk9wjr1 56 44 care care NN cord-026384-ejk9wjr1 56 45 following follow VBG cord-026384-ejk9wjr1 56 46 delivery delivery NN cord-026384-ejk9wjr1 56 47 . . . cord-026384-ejk9wjr1 57 1 Finally finally RB cord-026384-ejk9wjr1 57 2 , , , cord-026384-ejk9wjr1 57 3 we -PRON- PRP cord-026384-ejk9wjr1 57 4 excluded exclude VBD cord-026384-ejk9wjr1 57 5 tools tool NNS cord-026384-ejk9wjr1 57 6 that that WDT cord-026384-ejk9wjr1 57 7 only only RB cord-026384-ejk9wjr1 57 8 predicted predict VBD cord-026384-ejk9wjr1 57 9 outcomes outcome NNS cord-026384-ejk9wjr1 57 10 to to IN cord-026384-ejk9wjr1 57 11 an an DT cord-026384-ejk9wjr1 57 12 age age NN cord-026384-ejk9wjr1 57 13 of of IN cord-026384-ejk9wjr1 57 14 < < $ cord-026384-ejk9wjr1 57 15 6 6 CD cord-026384-ejk9wjr1 57 16 months month NNS cord-026384-ejk9wjr1 57 17 corrected correct VBD cord-026384-ejk9wjr1 57 18 age age NN cord-026384-ejk9wjr1 57 19 , , , cord-026384-ejk9wjr1 57 20 as as RB cord-026384-ejk9wjr1 57 21 well well RB cord-026384-ejk9wjr1 57 22 as as IN cord-026384-ejk9wjr1 57 23 case case NN cord-026384-ejk9wjr1 57 24 reports report NNS cord-026384-ejk9wjr1 57 25 , , , cord-026384-ejk9wjr1 57 26 narrative narrative NN cord-026384-ejk9wjr1 57 27 reviews review NNS cord-026384-ejk9wjr1 57 28 , , , cord-026384-ejk9wjr1 57 29 and and CC cord-026384-ejk9wjr1 57 30 tools tool NNS cord-026384-ejk9wjr1 57 31 reported report VBN cord-026384-ejk9wjr1 57 32 in in IN cord-026384-ejk9wjr1 57 33 languages language NNS cord-026384-ejk9wjr1 57 34 other other JJ cord-026384-ejk9wjr1 57 35 than than IN cord-026384-ejk9wjr1 57 36 English English NNP cord-026384-ejk9wjr1 57 37 . . . cord-026384-ejk9wjr1 58 1 Overview overview NN cord-026384-ejk9wjr1 58 2 of of IN cord-026384-ejk9wjr1 58 3 risk risk NN cord-026384-ejk9wjr1 58 4 prediction prediction NN cord-026384-ejk9wjr1 58 5 models model NNS cord-026384-ejk9wjr1 58 6 Table Table NNP cord-026384-ejk9wjr1 59 1 2 2 LS cord-026384-ejk9wjr1 59 2 lists list VBZ cord-026384-ejk9wjr1 59 3 all all DT cord-026384-ejk9wjr1 59 4 32 32 CD cord-026384-ejk9wjr1 59 5 studies study NNS cord-026384-ejk9wjr1 59 6 with with IN cord-026384-ejk9wjr1 59 7 risk risk NN cord-026384-ejk9wjr1 59 8 prediction prediction NN cord-026384-ejk9wjr1 59 9 models model NNS cord-026384-ejk9wjr1 59 10 that that WDT cord-026384-ejk9wjr1 59 11 meet meet VBP cord-026384-ejk9wjr1 59 12 the the DT cord-026384-ejk9wjr1 59 13 inclusion inclusion NN cord-026384-ejk9wjr1 59 14 and and CC cord-026384-ejk9wjr1 59 15 exclusion exclusion NN cord-026384-ejk9wjr1 59 16 criteria criterion NNS cord-026384-ejk9wjr1 59 17 . . . cord-026384-ejk9wjr1 60 1 [ [ -LRB- cord-026384-ejk9wjr1 60 2 13 13 CD cord-026384-ejk9wjr1 60 3 ] ] -RRB- cord-026384-ejk9wjr1 60 4 [ [ -LRB- cord-026384-ejk9wjr1 60 5 14 14 CD cord-026384-ejk9wjr1 60 6 ] ] -RRB- cord-026384-ejk9wjr1 61 1 [ [ -LRB- cord-026384-ejk9wjr1 61 2 15 15 CD cord-026384-ejk9wjr1 61 3 ] ] -RRB- cord-026384-ejk9wjr1 62 1 From from IN cord-026384-ejk9wjr1 62 2 these these DT cord-026384-ejk9wjr1 62 3 , , , cord-026384-ejk9wjr1 62 4 a a DT cord-026384-ejk9wjr1 62 5 total total NN cord-026384-ejk9wjr1 62 6 of of IN cord-026384-ejk9wjr1 62 7 43 43 CD cord-026384-ejk9wjr1 62 8 distinct distinct JJ cord-026384-ejk9wjr1 62 9 models model NNS cord-026384-ejk9wjr1 62 10 were be VBD cord-026384-ejk9wjr1 62 11 reported report VBN cord-026384-ejk9wjr1 62 12 . . . cord-026384-ejk9wjr1 63 1 From from IN cord-026384-ejk9wjr1 63 2 mortality mortality NN cord-026384-ejk9wjr1 63 3 to to IN cord-026384-ejk9wjr1 63 4 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 63 5 impairment impairment NN cord-026384-ejk9wjr1 63 6 Since since IN cord-026384-ejk9wjr1 63 7 1990 1990 CD cord-026384-ejk9wjr1 63 8 , , , cord-026384-ejk9wjr1 63 9 several several JJ cord-026384-ejk9wjr1 63 10 mortality mortality NN cord-026384-ejk9wjr1 63 11 prediction prediction NN cord-026384-ejk9wjr1 63 12 tools tool NNS cord-026384-ejk9wjr1 63 13 have have VBP cord-026384-ejk9wjr1 63 14 been be VBN cord-026384-ejk9wjr1 63 15 evaluated evaluate VBN cord-026384-ejk9wjr1 63 16 in in IN cord-026384-ejk9wjr1 63 17 regards regard NNS cord-026384-ejk9wjr1 63 18 to to IN cord-026384-ejk9wjr1 63 19 their -PRON- PRP$ cord-026384-ejk9wjr1 63 20 ability ability NN cord-026384-ejk9wjr1 63 21 to to TO cord-026384-ejk9wjr1 63 22 predict predict VB cord-026384-ejk9wjr1 63 23 the the DT cord-026384-ejk9wjr1 63 24 likelihood likelihood NN cord-026384-ejk9wjr1 63 25 of of IN cord-026384-ejk9wjr1 63 26 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 63 27 impairment impairment NN cord-026384-ejk9wjr1 63 28 ( ( -LRB- cord-026384-ejk9wjr1 63 29 NDI NDI NNP cord-026384-ejk9wjr1 63 30 ) ) -RRB- cord-026384-ejk9wjr1 63 31 among among IN cord-026384-ejk9wjr1 63 32 neonates neonate NNS cord-026384-ejk9wjr1 63 33 surviving survive VBG cord-026384-ejk9wjr1 63 34 to to IN cord-026384-ejk9wjr1 63 35 NICU NICU NNP cord-026384-ejk9wjr1 63 36 discharge discharge NN cord-026384-ejk9wjr1 63 37 . . . cord-026384-ejk9wjr1 64 1 One one CD cord-026384-ejk9wjr1 64 2 such such JJ cord-026384-ejk9wjr1 64 3 model model NN cord-026384-ejk9wjr1 64 4 is be VBZ cord-026384-ejk9wjr1 64 5 the the DT cord-026384-ejk9wjr1 64 6 CRIB CRIB NNP cord-026384-ejk9wjr1 64 7 , , , cord-026384-ejk9wjr1 64 8 which which WDT cord-026384-ejk9wjr1 64 9 incorporates incorporate VBZ cord-026384-ejk9wjr1 64 10 six six CD cord-026384-ejk9wjr1 64 11 physiologic physiologic JJ cord-026384-ejk9wjr1 64 12 variables variable NNS cord-026384-ejk9wjr1 64 13 collected collect VBN cord-026384-ejk9wjr1 64 14 within within IN cord-026384-ejk9wjr1 64 15 the the DT cord-026384-ejk9wjr1 64 16 first first JJ cord-026384-ejk9wjr1 64 17 12 12 CD cord-026384-ejk9wjr1 64 18 h h NN cord-026384-ejk9wjr1 64 19 of of IN cord-026384-ejk9wjr1 64 20 the the DT cord-026384-ejk9wjr1 64 21 preterm preterm JJ cord-026384-ejk9wjr1 64 22 infant infant NN cord-026384-ejk9wjr1 64 23 's 's POS cord-026384-ejk9wjr1 64 24 life life NN cord-026384-ejk9wjr1 64 25 : : : cord-026384-ejk9wjr1 64 26 birth birth NN cord-026384-ejk9wjr1 64 27 weight weight NN cord-026384-ejk9wjr1 64 28 , , , cord-026384-ejk9wjr1 64 29 gestational gestational JJ cord-026384-ejk9wjr1 64 30 age age NN cord-026384-ejk9wjr1 64 31 , , , cord-026384-ejk9wjr1 64 32 presence presence NN cord-026384-ejk9wjr1 64 33 of of IN cord-026384-ejk9wjr1 64 34 congenital congenital JJ cord-026384-ejk9wjr1 64 35 malformations malformation NNS cord-026384-ejk9wjr1 64 36 , , , cord-026384-ejk9wjr1 64 37 maximum maximum JJ cord-026384-ejk9wjr1 64 38 base base NN cord-026384-ejk9wjr1 64 39 excess excess NN cord-026384-ejk9wjr1 64 40 , , , cord-026384-ejk9wjr1 64 41 and and CC cord-026384-ejk9wjr1 64 42 minimum minimum NN cord-026384-ejk9wjr1 64 43 and and CC cord-026384-ejk9wjr1 64 44 maximum maximum JJ cord-026384-ejk9wjr1 64 45 FiO FiO NNS cord-026384-ejk9wjr1 64 46 2 2 CD cord-026384-ejk9wjr1 64 47 requirement requirement NN cord-026384-ejk9wjr1 64 48 . . . cord-026384-ejk9wjr1 65 1 50 50 CD cord-026384-ejk9wjr1 65 2 Fowlie Fowlie NNP cord-026384-ejk9wjr1 65 3 et et NNP cord-026384-ejk9wjr1 65 4 al al NNP cord-026384-ejk9wjr1 65 5 . . . cord-026384-ejk9wjr1 66 1 24 24 CD cord-026384-ejk9wjr1 66 2 evaluated evaluate VBD cord-026384-ejk9wjr1 66 3 how how WRB cord-026384-ejk9wjr1 66 4 CRIB CRIB NNP cord-026384-ejk9wjr1 66 5 models model NNS cord-026384-ejk9wjr1 66 6 obtained obtain VBN cord-026384-ejk9wjr1 66 7 at at IN cord-026384-ejk9wjr1 66 8 differing differ VBG cord-026384-ejk9wjr1 66 9 time time NN cord-026384-ejk9wjr1 66 10 periods period NNS cord-026384-ejk9wjr1 66 11 over over IN cord-026384-ejk9wjr1 66 12 the the DT cord-026384-ejk9wjr1 66 13 first first JJ cord-026384-ejk9wjr1 66 14 7 7 CD cord-026384-ejk9wjr1 66 15 days day NNS cord-026384-ejk9wjr1 66 16 of of IN cord-026384-ejk9wjr1 66 17 life life NN cord-026384-ejk9wjr1 66 18 predicted predict VBD cord-026384-ejk9wjr1 66 19 severe severe JJ cord-026384-ejk9wjr1 66 20 disability disability NN cord-026384-ejk9wjr1 66 21 among among IN cord-026384-ejk9wjr1 66 22 a a DT cord-026384-ejk9wjr1 66 23 group group NN cord-026384-ejk9wjr1 66 24 of of IN cord-026384-ejk9wjr1 66 25 infants infant NNS cord-026384-ejk9wjr1 66 26 born bear VBN cord-026384-ejk9wjr1 66 27 > > XX cord-026384-ejk9wjr1 66 28 31 31 CD cord-026384-ejk9wjr1 66 29 weeks week NNS cord-026384-ejk9wjr1 66 30 gestational gestational JJ cord-026384-ejk9wjr1 66 31 age age NN cord-026384-ejk9wjr1 66 32 or or CC cord-026384-ejk9wjr1 66 33 VLBW VLBW NNP cord-026384-ejk9wjr1 66 34 . . . cord-026384-ejk9wjr1 67 1 In in IN cord-026384-ejk9wjr1 67 2 another another DT cord-026384-ejk9wjr1 67 3 study study NN cord-026384-ejk9wjr1 67 4 , , , cord-026384-ejk9wjr1 67 5 Fowlie Fowlie NNP cord-026384-ejk9wjr1 67 6 et et NNP cord-026384-ejk9wjr1 67 7 al al NNP cord-026384-ejk9wjr1 67 8 . . . cord-026384-ejk9wjr1 67 9 25 25 CD cord-026384-ejk9wjr1 67 10 incorporated incorporate VBN cord-026384-ejk9wjr1 67 11 cranial cranial JJ cord-026384-ejk9wjr1 67 12 ultrasound ultrasound NN cord-026384-ejk9wjr1 67 13 findings finding NNS cord-026384-ejk9wjr1 67 14 on on IN cord-026384-ejk9wjr1 67 15 day day NN cord-026384-ejk9wjr1 67 16 of of IN cord-026384-ejk9wjr1 67 17 life life NN cord-026384-ejk9wjr1 67 18 3 3 CD cord-026384-ejk9wjr1 67 19 along along RB cord-026384-ejk9wjr1 67 20 with with IN cord-026384-ejk9wjr1 67 21 CRIB crib NN cord-026384-ejk9wjr1 67 22 scores score NNS cord-026384-ejk9wjr1 67 23 between between IN cord-026384-ejk9wjr1 67 24 48 48 CD cord-026384-ejk9wjr1 67 25 and and CC cord-026384-ejk9wjr1 67 26 72 72 CD cord-026384-ejk9wjr1 67 27 h h NN cord-026384-ejk9wjr1 67 28 of of IN cord-026384-ejk9wjr1 67 29 life life NN cord-026384-ejk9wjr1 67 30 into into IN cord-026384-ejk9wjr1 67 31 their -PRON- PRP$ cord-026384-ejk9wjr1 67 32 prediction prediction NN cord-026384-ejk9wjr1 67 33 model model NN cord-026384-ejk9wjr1 67 34 . . . cord-026384-ejk9wjr1 68 1 Subsequent subsequent JJ cord-026384-ejk9wjr1 68 2 studies study NNS cord-026384-ejk9wjr1 68 3 analyzed analyze VBD cord-026384-ejk9wjr1 68 4 the the DT cord-026384-ejk9wjr1 68 5 CRIB crib NN cord-026384-ejk9wjr1 68 6 in in IN cord-026384-ejk9wjr1 68 7 its -PRON- PRP$ cord-026384-ejk9wjr1 68 8 original original JJ cord-026384-ejk9wjr1 68 9 12-h 12-h CD cord-026384-ejk9wjr1 68 10 form form NN cord-026384-ejk9wjr1 68 11 and and CC cord-026384-ejk9wjr1 68 12 , , , cord-026384-ejk9wjr1 68 13 with with IN cord-026384-ejk9wjr1 68 14 only only RB cord-026384-ejk9wjr1 68 15 one one CD cord-026384-ejk9wjr1 68 16 exception exception NN cord-026384-ejk9wjr1 68 17 , , , cord-026384-ejk9wjr1 68 18 23 23 CD cord-026384-ejk9wjr1 68 19 determined determine VBD cord-026384-ejk9wjr1 68 20 that that IN cord-026384-ejk9wjr1 68 21 it -PRON- PRP cord-026384-ejk9wjr1 68 22 was be VBD cord-026384-ejk9wjr1 68 23 not not RB cord-026384-ejk9wjr1 68 24 a a DT cord-026384-ejk9wjr1 68 25 useful useful JJ cord-026384-ejk9wjr1 68 26 tool tool NN cord-026384-ejk9wjr1 68 27 for for IN cord-026384-ejk9wjr1 68 28 predicting predict VBG cord-026384-ejk9wjr1 68 29 long long JJ cord-026384-ejk9wjr1 68 30 - - HYPH cord-026384-ejk9wjr1 68 31 term term NN cord-026384-ejk9wjr1 68 32 NDI NDI NNP cord-026384-ejk9wjr1 68 33 or or CC cord-026384-ejk9wjr1 68 34 other other JJ cord-026384-ejk9wjr1 68 35 morbidities morbidity NNS cord-026384-ejk9wjr1 68 36 . . . cord-026384-ejk9wjr1 69 1 [ [ -LRB- cord-026384-ejk9wjr1 69 2 26 26 CD cord-026384-ejk9wjr1 69 3 ] ] -RRB- cord-026384-ejk9wjr1 69 4 [ [ -LRB- cord-026384-ejk9wjr1 69 5 27 27 CD cord-026384-ejk9wjr1 69 6 ] ] -RRB- cord-026384-ejk9wjr1 69 7 [ [ -LRB- cord-026384-ejk9wjr1 69 8 28 28 CD cord-026384-ejk9wjr1 69 9 ] ] -RRB- cord-026384-ejk9wjr1 70 1 [ [ -LRB- cord-026384-ejk9wjr1 70 2 29 29 CD cord-026384-ejk9wjr1 70 3 ] ] -RRB- cord-026384-ejk9wjr1 71 1 A a DT cord-026384-ejk9wjr1 71 2 second second JJ cord-026384-ejk9wjr1 71 3 example example NN cord-026384-ejk9wjr1 71 4 is be VBZ cord-026384-ejk9wjr1 71 5 the the DT cord-026384-ejk9wjr1 71 6 SNAP snap JJ cord-026384-ejk9wjr1 71 7 score score NN cord-026384-ejk9wjr1 71 8 . . . cord-026384-ejk9wjr1 72 1 51 51 CD cord-026384-ejk9wjr1 72 2 SNAP snap VB cord-026384-ejk9wjr1 72 3 uses use VBZ cord-026384-ejk9wjr1 72 4 28 28 CD cord-026384-ejk9wjr1 72 5 physiologic physiologic JJ cord-026384-ejk9wjr1 72 6 parameters parameter NNS cord-026384-ejk9wjr1 72 7 collected collect VBN cord-026384-ejk9wjr1 72 8 over over IN cord-026384-ejk9wjr1 72 9 the the DT cord-026384-ejk9wjr1 72 10 first first JJ cord-026384-ejk9wjr1 72 11 24 24 CD cord-026384-ejk9wjr1 72 12 h h NN cord-026384-ejk9wjr1 72 13 of of IN cord-026384-ejk9wjr1 72 14 life life NN cord-026384-ejk9wjr1 72 15 to to TO cord-026384-ejk9wjr1 72 16 predict predict VB cord-026384-ejk9wjr1 72 17 survival survival NN cord-026384-ejk9wjr1 72 18 to to IN cord-026384-ejk9wjr1 72 19 NICU NICU NNP cord-026384-ejk9wjr1 72 20 discharge discharge NN cord-026384-ejk9wjr1 72 21 , , , cord-026384-ejk9wjr1 72 22 and and CC cord-026384-ejk9wjr1 72 23 was be VBD cord-026384-ejk9wjr1 72 24 modified modify VBN cord-026384-ejk9wjr1 72 25 to to TO cord-026384-ejk9wjr1 72 26 predict predict VB cord-026384-ejk9wjr1 72 27 NDI NDI NNP cord-026384-ejk9wjr1 72 28 at at IN cord-026384-ejk9wjr1 72 29 1 1 CD cord-026384-ejk9wjr1 72 30 year year NN cord-026384-ejk9wjr1 72 31 and and CC cord-026384-ejk9wjr1 72 32 2 2 CD cord-026384-ejk9wjr1 72 33 - - SYM cord-026384-ejk9wjr1 72 34 3 3 CD cord-026384-ejk9wjr1 72 35 years year NNS cord-026384-ejk9wjr1 72 36 of of IN cord-026384-ejk9wjr1 72 37 age age NN cord-026384-ejk9wjr1 72 38 . . . cord-026384-ejk9wjr1 73 1 A a DT cord-026384-ejk9wjr1 73 2 subsequent subsequent JJ cord-026384-ejk9wjr1 73 3 assessment assessment NN cord-026384-ejk9wjr1 73 4 of of IN cord-026384-ejk9wjr1 73 5 both both CC cord-026384-ejk9wjr1 73 6 the the DT cord-026384-ejk9wjr1 73 7 SNAP snap NN cord-026384-ejk9wjr1 73 8 and and CC cord-026384-ejk9wjr1 73 9 the the DT cord-026384-ejk9wjr1 73 10 SNAP snap NN cord-026384-ejk9wjr1 73 11 with with IN cord-026384-ejk9wjr1 73 12 Perinatal Perinatal NNP cord-026384-ejk9wjr1 73 13 Extension Extension NNP cord-026384-ejk9wjr1 73 14 42 42 CD cord-026384-ejk9wjr1 73 15 showed show VBD cord-026384-ejk9wjr1 73 16 a a DT cord-026384-ejk9wjr1 73 17 poor poor JJ cord-026384-ejk9wjr1 73 18 predictive predictive JJ cord-026384-ejk9wjr1 73 19 value value NN cord-026384-ejk9wjr1 73 20 for for IN cord-026384-ejk9wjr1 73 21 morbidity morbidity NN cord-026384-ejk9wjr1 73 22 at at IN cord-026384-ejk9wjr1 73 23 4 4 CD cord-026384-ejk9wjr1 73 24 years year NNS cord-026384-ejk9wjr1 73 25 of of IN cord-026384-ejk9wjr1 73 26 age age NN cord-026384-ejk9wjr1 73 27 for for IN cord-026384-ejk9wjr1 73 28 children child NNS cord-026384-ejk9wjr1 73 29 born bear VBN cord-026384-ejk9wjr1 73 30 VLBW VLBW NNP cord-026384-ejk9wjr1 73 31 and/or and/or CC cord-026384-ejk9wjr1 73 32 with with IN cord-026384-ejk9wjr1 73 33 gestational gestational JJ cord-026384-ejk9wjr1 73 34 age age NN cord-026384-ejk9wjr1 73 35 ≤31 ≤31 ADD cord-026384-ejk9wjr1 73 36 weeks week NNS cord-026384-ejk9wjr1 73 37 . . . cord-026384-ejk9wjr1 74 1 28 28 CD cord-026384-ejk9wjr1 75 1 Finally finally RB cord-026384-ejk9wjr1 75 2 , , , cord-026384-ejk9wjr1 75 3 the the DT cord-026384-ejk9wjr1 75 4 Neonatal Neonatal NNP cord-026384-ejk9wjr1 75 5 Therapeutic Therapeutic NNP cord-026384-ejk9wjr1 75 6 Intervention Intervention NNP cord-026384-ejk9wjr1 75 7 Scoring Scoring NNP cord-026384-ejk9wjr1 75 8 System System NNP cord-026384-ejk9wjr1 75 9 , , , cord-026384-ejk9wjr1 75 10 a a DT cord-026384-ejk9wjr1 75 11 comprehensive comprehensive JJ cord-026384-ejk9wjr1 75 12 exam exam NN cord-026384-ejk9wjr1 75 13 - - HYPH cord-026384-ejk9wjr1 75 14 based base VBN cord-026384-ejk9wjr1 75 15 prediction prediction NN cord-026384-ejk9wjr1 75 16 tool tool NN cord-026384-ejk9wjr1 75 17 for for IN cord-026384-ejk9wjr1 75 18 mortality mortality NN cord-026384-ejk9wjr1 75 19 , , , cord-026384-ejk9wjr1 75 20 52 52 CD cord-026384-ejk9wjr1 75 21 was be VBD cord-026384-ejk9wjr1 75 22 found find VBN cord-026384-ejk9wjr1 75 23 to to TO cord-026384-ejk9wjr1 75 24 have have VB cord-026384-ejk9wjr1 75 25 a a DT cord-026384-ejk9wjr1 75 26 poor poor JJ cord-026384-ejk9wjr1 75 27 predictive predictive JJ cord-026384-ejk9wjr1 75 28 value value NN cord-026384-ejk9wjr1 75 29 for for IN cord-026384-ejk9wjr1 75 30 adverse adverse JJ cord-026384-ejk9wjr1 75 31 outcomes outcome NNS cord-026384-ejk9wjr1 75 32 at at IN cord-026384-ejk9wjr1 75 33 4 4 CD cord-026384-ejk9wjr1 75 34 years year NNS cord-026384-ejk9wjr1 75 35 of of IN cord-026384-ejk9wjr1 75 36 age age NN cord-026384-ejk9wjr1 75 37 in in IN cord-026384-ejk9wjr1 75 38 children child NNS cord-026384-ejk9wjr1 75 39 born bear VBD cord-026384-ejk9wjr1 75 40 very very RB cord-026384-ejk9wjr1 75 41 preterm preterm NNS cord-026384-ejk9wjr1 75 42 or or CC cord-026384-ejk9wjr1 75 43 VLBW VLBW NNP cord-026384-ejk9wjr1 75 44 . . . cord-026384-ejk9wjr1 76 1 28 28 CD cord-026384-ejk9wjr1 76 2 Shortened shorten VBN cord-026384-ejk9wjr1 76 3 forms form NNS cord-026384-ejk9wjr1 76 4 of of IN cord-026384-ejk9wjr1 76 5 the the DT cord-026384-ejk9wjr1 76 6 early early JJ cord-026384-ejk9wjr1 76 7 physiology physiology NN cord-026384-ejk9wjr1 76 8 - - HYPH cord-026384-ejk9wjr1 76 9 based base VBN cord-026384-ejk9wjr1 76 10 scoring scoring NN cord-026384-ejk9wjr1 76 11 systems system NNS cord-026384-ejk9wjr1 76 12 were be VBD cord-026384-ejk9wjr1 76 13 developed develop VBN cord-026384-ejk9wjr1 76 14 and and CC cord-026384-ejk9wjr1 76 15 assessed assess VBN cord-026384-ejk9wjr1 76 16 for for IN cord-026384-ejk9wjr1 76 17 their -PRON- PRP$ cord-026384-ejk9wjr1 76 18 ability ability NN cord-026384-ejk9wjr1 76 19 to to TO cord-026384-ejk9wjr1 76 20 predict predict VB cord-026384-ejk9wjr1 76 21 outcomes outcome NNS cord-026384-ejk9wjr1 76 22 in in IN cord-026384-ejk9wjr1 76 23 childhood childhood NN cord-026384-ejk9wjr1 76 24 . . . cord-026384-ejk9wjr1 77 1 Application application NN cord-026384-ejk9wjr1 77 2 of of IN cord-026384-ejk9wjr1 77 3 the the DT cord-026384-ejk9wjr1 77 4 CRIB CRIB NNP cord-026384-ejk9wjr1 77 5 - - HYPH cord-026384-ejk9wjr1 77 6 II II NNP cord-026384-ejk9wjr1 77 7 on on IN cord-026384-ejk9wjr1 77 8 a a DT cord-026384-ejk9wjr1 77 9 small small JJ cord-026384-ejk9wjr1 77 10 cohort cohort NN cord-026384-ejk9wjr1 77 11 ( ( -LRB- cord-026384-ejk9wjr1 77 12 n n NN cord-026384-ejk9wjr1 77 13 = = SYM cord-026384-ejk9wjr1 77 14 107 107 CD cord-026384-ejk9wjr1 77 15 ) ) -RRB- cord-026384-ejk9wjr1 77 16 of of IN cord-026384-ejk9wjr1 77 17 infants infant NNS cord-026384-ejk9wjr1 77 18 born bear VBN cord-026384-ejk9wjr1 78 1 < < NNP cord-026384-ejk9wjr1 78 2 1250 1250 CD cord-026384-ejk9wjr1 78 3 g g NNP cord-026384-ejk9wjr1 78 4 predicted predict VBD cord-026384-ejk9wjr1 78 5 significant significant JJ cord-026384-ejk9wjr1 78 6 NDI NDI NNP cord-026384-ejk9wjr1 78 7 at at IN cord-026384-ejk9wjr1 78 8 3 3 CD cord-026384-ejk9wjr1 78 9 years year NNS cord-026384-ejk9wjr1 78 10 of of IN cord-026384-ejk9wjr1 78 11 age age NN cord-026384-ejk9wjr1 78 12 . . . cord-026384-ejk9wjr1 79 1 39 39 CD cord-026384-ejk9wjr1 80 1 However however RB cord-026384-ejk9wjr1 80 2 , , , cord-026384-ejk9wjr1 80 3 a a DT cord-026384-ejk9wjr1 80 4 subsequent subsequent JJ cord-026384-ejk9wjr1 80 5 evaluation evaluation NN cord-026384-ejk9wjr1 80 6 in in IN cord-026384-ejk9wjr1 80 7 a a DT cord-026384-ejk9wjr1 80 8 much much RB cord-026384-ejk9wjr1 80 9 larger large JJR cord-026384-ejk9wjr1 80 10 cohort cohort NN cord-026384-ejk9wjr1 80 11 ( ( -LRB- cord-026384-ejk9wjr1 80 12 n n NN cord-026384-ejk9wjr1 80 13 = = SYM cord-026384-ejk9wjr1 80 14 1328 1328 CD cord-026384-ejk9wjr1 80 15 ) ) -RRB- cord-026384-ejk9wjr1 80 16 of of IN cord-026384-ejk9wjr1 80 17 preterm preterm JJ cord-026384-ejk9wjr1 80 18 infants infant NNS cord-026384-ejk9wjr1 81 1 < < NNP cord-026384-ejk9wjr1 81 2 29 29 CD cord-026384-ejk9wjr1 81 3 weeks week NNS cord-026384-ejk9wjr1 82 1 gestational gestational JJ cord-026384-ejk9wjr1 82 2 age age NN cord-026384-ejk9wjr1 82 3 concluded conclude VBD cord-026384-ejk9wjr1 82 4 that that IN cord-026384-ejk9wjr1 82 5 the the DT cord-026384-ejk9wjr1 82 6 CRIB CRIB NNP cord-026384-ejk9wjr1 82 7 - - HYPH cord-026384-ejk9wjr1 82 8 II II NNP cord-026384-ejk9wjr1 82 9 did do VBD cord-026384-ejk9wjr1 82 10 no no RB cord-026384-ejk9wjr1 82 11 better well JJR cord-026384-ejk9wjr1 82 12 than than IN cord-026384-ejk9wjr1 82 13 gestational gestational JJ cord-026384-ejk9wjr1 82 14 age age NN cord-026384-ejk9wjr1 82 15 or or CC cord-026384-ejk9wjr1 82 16 birth birth NN cord-026384-ejk9wjr1 82 17 weight weight NN cord-026384-ejk9wjr1 82 18 alone alone RB cord-026384-ejk9wjr1 82 19 in in IN cord-026384-ejk9wjr1 82 20 predicting predict VBG cord-026384-ejk9wjr1 82 21 moderate moderate JJ cord-026384-ejk9wjr1 82 22 to to IN cord-026384-ejk9wjr1 82 23 severe severe JJ cord-026384-ejk9wjr1 82 24 functional functional JJ cord-026384-ejk9wjr1 82 25 disability disability NN cord-026384-ejk9wjr1 82 26 at at IN cord-026384-ejk9wjr1 82 27 2 2 CD cord-026384-ejk9wjr1 82 28 - - SYM cord-026384-ejk9wjr1 82 29 3 3 CD cord-026384-ejk9wjr1 82 30 years year NNS cord-026384-ejk9wjr1 82 31 of of IN cord-026384-ejk9wjr1 82 32 age age NN cord-026384-ejk9wjr1 82 33 . . . cord-026384-ejk9wjr1 83 1 40 40 CD cord-026384-ejk9wjr1 83 2 Studies study NNS cord-026384-ejk9wjr1 83 3 have have VBP cord-026384-ejk9wjr1 83 4 supported support VBN cord-026384-ejk9wjr1 83 5 an an DT cord-026384-ejk9wjr1 83 6 association association NN cord-026384-ejk9wjr1 83 7 between between IN cord-026384-ejk9wjr1 83 8 the the DT cord-026384-ejk9wjr1 83 9 SNAP SNAP NNP cord-026384-ejk9wjr1 83 10 - - HYPH cord-026384-ejk9wjr1 83 11 II II NNP cord-026384-ejk9wjr1 83 12 and and CC cord-026384-ejk9wjr1 83 13 SNAPPE SNAPPE NNP cord-026384-ejk9wjr1 83 14 - - HYPH cord-026384-ejk9wjr1 83 15 II II NNP cord-026384-ejk9wjr1 83 16 scores score NNS cord-026384-ejk9wjr1 83 17 and and CC cord-026384-ejk9wjr1 83 18 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 83 19 outcomes outcome NNS cord-026384-ejk9wjr1 83 20 and and CC cord-026384-ejk9wjr1 84 1 small small JJ cord-026384-ejk9wjr1 84 2 head head NN cord-026384-ejk9wjr1 84 3 circumference circumference NN cord-026384-ejk9wjr1 84 4 at at IN cord-026384-ejk9wjr1 84 5 24 24 CD cord-026384-ejk9wjr1 84 6 months month NNS cord-026384-ejk9wjr1 84 7 corrected correct VBD cord-026384-ejk9wjr1 84 8 age age NN cord-026384-ejk9wjr1 84 9 . . . cord-026384-ejk9wjr1 85 1 High high JJ cord-026384-ejk9wjr1 85 2 SNAP snap NN cord-026384-ejk9wjr1 85 3 - - HYPH cord-026384-ejk9wjr1 85 4 II ii NN cord-026384-ejk9wjr1 85 5 scores score NNS cord-026384-ejk9wjr1 85 6 were be VBD cord-026384-ejk9wjr1 85 7 shown show VBN cord-026384-ejk9wjr1 85 8 to to TO cord-026384-ejk9wjr1 85 9 correlate correlate VB cord-026384-ejk9wjr1 85 10 with with IN cord-026384-ejk9wjr1 85 11 adverse adverse JJ cord-026384-ejk9wjr1 85 12 neurological neurological JJ cord-026384-ejk9wjr1 85 13 , , , cord-026384-ejk9wjr1 85 14 cognitive cognitive JJ cord-026384-ejk9wjr1 85 15 , , , cord-026384-ejk9wjr1 85 16 and and CC cord-026384-ejk9wjr1 85 17 behavioral behavioral JJ cord-026384-ejk9wjr1 85 18 outcomes outcome NNS cord-026384-ejk9wjr1 85 19 up up IN cord-026384-ejk9wjr1 85 20 to to TO cord-026384-ejk9wjr1 85 21 10 10 CD cord-026384-ejk9wjr1 85 22 years year NNS cord-026384-ejk9wjr1 85 23 of of IN cord-026384-ejk9wjr1 85 24 age age NN cord-026384-ejk9wjr1 85 25 within within IN cord-026384-ejk9wjr1 85 26 a a DT cord-026384-ejk9wjr1 85 27 large large JJ cord-026384-ejk9wjr1 85 28 cohort cohort NN cord-026384-ejk9wjr1 85 29 ( ( -LRB- cord-026384-ejk9wjr1 85 30 n n NN cord-026384-ejk9wjr1 85 31 = = SYM cord-026384-ejk9wjr1 85 32 874 874 CD cord-026384-ejk9wjr1 85 33 ) ) -RRB- cord-026384-ejk9wjr1 85 34 of of IN cord-026384-ejk9wjr1 85 35 children child NNS cord-026384-ejk9wjr1 85 36 born bear VBD cord-026384-ejk9wjr1 85 37 very very RB cord-026384-ejk9wjr1 85 38 preterm preterm NNS cord-026384-ejk9wjr1 85 39 . . . cord-026384-ejk9wjr1 86 1 43 43 CD cord-026384-ejk9wjr1 86 2 Antenatal Antenatal NNP cord-026384-ejk9wjr1 86 3 risk risk NN cord-026384-ejk9wjr1 86 4 factors factor NNS cord-026384-ejk9wjr1 87 1 Several several JJ cord-026384-ejk9wjr1 87 2 groups group NNS cord-026384-ejk9wjr1 87 3 have have VBP cord-026384-ejk9wjr1 87 4 used use VBN cord-026384-ejk9wjr1 87 5 data datum NNS cord-026384-ejk9wjr1 87 6 from from IN cord-026384-ejk9wjr1 87 7 the the DT cord-026384-ejk9wjr1 87 8 NICHD NICHD NNP cord-026384-ejk9wjr1 87 9 's 's POS cord-026384-ejk9wjr1 87 10 Neonatal Neonatal NNP cord-026384-ejk9wjr1 87 11 Research Research NNP cord-026384-ejk9wjr1 87 12 Network Network NNP cord-026384-ejk9wjr1 87 13 ( ( -LRB- cord-026384-ejk9wjr1 87 14 NRN NRN NNP cord-026384-ejk9wjr1 87 15 ) ) -RRB- cord-026384-ejk9wjr1 87 16 to to TO cord-026384-ejk9wjr1 87 17 design design VB cord-026384-ejk9wjr1 87 18 and and CC cord-026384-ejk9wjr1 87 19 test test VB cord-026384-ejk9wjr1 87 20 various various JJ cord-026384-ejk9wjr1 87 21 risk risk NN cord-026384-ejk9wjr1 87 22 prediction prediction NN cord-026384-ejk9wjr1 87 23 models model NNS cord-026384-ejk9wjr1 87 24 for for IN cord-026384-ejk9wjr1 87 25 extremely extremely RB cord-026384-ejk9wjr1 87 26 low low JJ cord-026384-ejk9wjr1 87 27 birth birth NN cord-026384-ejk9wjr1 87 28 weight weight NN cord-026384-ejk9wjr1 87 29 ( ( -LRB- cord-026384-ejk9wjr1 87 30 ELBW ELBW NNP cord-026384-ejk9wjr1 87 31 ) ) -RRB- cord-026384-ejk9wjr1 87 32 newborns newborn NNS cord-026384-ejk9wjr1 87 33 . . . cord-026384-ejk9wjr1 88 1 One one CD cord-026384-ejk9wjr1 88 2 of of IN cord-026384-ejk9wjr1 88 3 the the DT cord-026384-ejk9wjr1 88 4 most most RBS cord-026384-ejk9wjr1 88 5 widely widely RB cord-026384-ejk9wjr1 88 6 used use VBN cord-026384-ejk9wjr1 88 7 risk risk NN cord-026384-ejk9wjr1 88 8 prediction prediction NN cord-026384-ejk9wjr1 88 9 tools tool NNS cord-026384-ejk9wjr1 88 10 developed develop VBN cord-026384-ejk9wjr1 88 11 from from IN cord-026384-ejk9wjr1 88 12 this this DT cord-026384-ejk9wjr1 88 13 cohort cohort NN cord-026384-ejk9wjr1 88 14 was be VBD cord-026384-ejk9wjr1 88 15 by by IN cord-026384-ejk9wjr1 88 16 Tyson Tyson NNP cord-026384-ejk9wjr1 88 17 et et NNP cord-026384-ejk9wjr1 88 18 al al NNP cord-026384-ejk9wjr1 88 19 . . NNP cord-026384-ejk9wjr1 88 20 , , , cord-026384-ejk9wjr1 88 21 13 13 CD cord-026384-ejk9wjr1 88 22 Postnatal postnatal JJ cord-026384-ejk9wjr1 88 23 morbidity morbidity NN cord-026384-ejk9wjr1 89 1 A a DT cord-026384-ejk9wjr1 89 2 large large JJ cord-026384-ejk9wjr1 89 3 cohort cohort NN cord-026384-ejk9wjr1 89 4 study study NN cord-026384-ejk9wjr1 89 5 ( ( -LRB- cord-026384-ejk9wjr1 89 6 n n NN cord-026384-ejk9wjr1 89 7 = = SYM cord-026384-ejk9wjr1 89 8 910 910 CD cord-026384-ejk9wjr1 89 9 ) ) -RRB- cord-026384-ejk9wjr1 89 10 from from IN cord-026384-ejk9wjr1 89 11 Schmidt Schmidt NNP cord-026384-ejk9wjr1 89 12 et et NNP cord-026384-ejk9wjr1 89 13 al al NNP cord-026384-ejk9wjr1 89 14 . . . cord-026384-ejk9wjr1 90 1 15 15 CD cord-026384-ejk9wjr1 90 2 , , , cord-026384-ejk9wjr1 90 3 32 32 CD cord-026384-ejk9wjr1 90 4 used use VBN cord-026384-ejk9wjr1 90 5 data datum NNS cord-026384-ejk9wjr1 90 6 from from IN cord-026384-ejk9wjr1 90 7 ELBW ELBW NNP cord-026384-ejk9wjr1 90 8 neonates neonate NNS cord-026384-ejk9wjr1 90 9 500 500 CD cord-026384-ejk9wjr1 90 10 - - SYM cord-026384-ejk9wjr1 90 11 999 999 CD cord-026384-ejk9wjr1 91 1 g g NNP cord-026384-ejk9wjr1 91 2 enrolled enrol VBD cord-026384-ejk9wjr1 91 3 in in IN cord-026384-ejk9wjr1 91 4 the the DT cord-026384-ejk9wjr1 91 5 international international JJ cord-026384-ejk9wjr1 91 6 Trial Trial NNP cord-026384-ejk9wjr1 91 7 of of IN cord-026384-ejk9wjr1 91 8 Indomethacin Indomethacin NNP cord-026384-ejk9wjr1 91 9 Prophylaxis Prophylaxis NNP cord-026384-ejk9wjr1 91 10 in in IN cord-026384-ejk9wjr1 91 11 Preterms Preterms NNP cord-026384-ejk9wjr1 91 12 ( ( -LRB- cord-026384-ejk9wjr1 91 13 TIPP TIPP NNP cord-026384-ejk9wjr1 91 14 ) ) -RRB- cord-026384-ejk9wjr1 91 15 . . . cord-026384-ejk9wjr1 92 1 They -PRON- PRP cord-026384-ejk9wjr1 92 2 found find VBD cord-026384-ejk9wjr1 92 3 that that IN cord-026384-ejk9wjr1 92 4 the the DT cord-026384-ejk9wjr1 92 5 presence presence NN cord-026384-ejk9wjr1 92 6 of of IN cord-026384-ejk9wjr1 92 7 three three CD cord-026384-ejk9wjr1 92 8 morbidities morbidity NNS cord-026384-ejk9wjr1 92 9 at at IN cord-026384-ejk9wjr1 92 10 36 36 CD cord-026384-ejk9wjr1 92 11 weeks week NNS cord-026384-ejk9wjr1 92 12 post post JJ cord-026384-ejk9wjr1 92 13 - - JJ cord-026384-ejk9wjr1 92 14 menstrual menstrual JJ cord-026384-ejk9wjr1 92 15 age age NN cord-026384-ejk9wjr1 93 1 -bronchopulmonary -bronchopulmonary JJ cord-026384-ejk9wjr1 94 1 dysplasia dysplasia NN cord-026384-ejk9wjr1 94 2 , , , cord-026384-ejk9wjr1 94 3 serious serious JJ cord-026384-ejk9wjr1 94 4 brain brain NN cord-026384-ejk9wjr1 94 5 injury injury NN cord-026384-ejk9wjr1 94 6 , , , cord-026384-ejk9wjr1 94 7 and and CC cord-026384-ejk9wjr1 94 8 severe severe JJ cord-026384-ejk9wjr1 94 9 retinopathy retinopathy NN cord-026384-ejk9wjr1 94 10 of of IN cord-026384-ejk9wjr1 94 11 prematurity prematurity NN cord-026384-ejk9wjr1 94 12 - - , cord-026384-ejk9wjr1 94 13 had have VBD cord-026384-ejk9wjr1 94 14 a a DT cord-026384-ejk9wjr1 94 15 significant significant JJ cord-026384-ejk9wjr1 94 16 and and CC cord-026384-ejk9wjr1 94 17 additive additive NN cord-026384-ejk9wjr1 94 18 effect effect NN cord-026384-ejk9wjr1 94 19 on on IN cord-026384-ejk9wjr1 94 20 the the DT cord-026384-ejk9wjr1 94 21 risk risk NN cord-026384-ejk9wjr1 94 22 for for IN cord-026384-ejk9wjr1 94 23 death death NN cord-026384-ejk9wjr1 94 24 or or CC cord-026384-ejk9wjr1 94 25 poor poor JJ cord-026384-ejk9wjr1 94 26 neurologic neurologic JJ cord-026384-ejk9wjr1 94 27 outcome outcome NN cord-026384-ejk9wjr1 94 28 at at IN cord-026384-ejk9wjr1 94 29 18 18 CD cord-026384-ejk9wjr1 94 30 months month NNS cord-026384-ejk9wjr1 95 1 corrected correct VBN cord-026384-ejk9wjr1 95 2 age age NN cord-026384-ejk9wjr1 95 3 . . . cord-026384-ejk9wjr1 96 1 They -PRON- PRP cord-026384-ejk9wjr1 96 2 developed develop VBD cord-026384-ejk9wjr1 96 3 a a DT cord-026384-ejk9wjr1 96 4 model model NN cord-026384-ejk9wjr1 96 5 from from IN cord-026384-ejk9wjr1 96 6 this this DT cord-026384-ejk9wjr1 96 7 relationship relationship NN cord-026384-ejk9wjr1 96 8 that that WDT cord-026384-ejk9wjr1 96 9 has have VBZ cord-026384-ejk9wjr1 96 10 been be VBN cord-026384-ejk9wjr1 96 11 corroborated corroborate VBN cord-026384-ejk9wjr1 96 12 in in IN cord-026384-ejk9wjr1 96 13 two two CD cord-026384-ejk9wjr1 96 14 studies study NNS cord-026384-ejk9wjr1 96 15 with with IN cord-026384-ejk9wjr1 96 16 smaller small JJR cord-026384-ejk9wjr1 96 17 samples sample NNS cord-026384-ejk9wjr1 96 18 and and CC cord-026384-ejk9wjr1 96 19 by by IN cord-026384-ejk9wjr1 96 20 Schmidt Schmidt NNP cord-026384-ejk9wjr1 96 21 et et NNP cord-026384-ejk9wjr1 96 22 al al NNP cord-026384-ejk9wjr1 96 23 . . . cord-026384-ejk9wjr1 97 1 15 15 CD cord-026384-ejk9wjr1 97 2 in in IN cord-026384-ejk9wjr1 97 3 a a DT cord-026384-ejk9wjr1 97 4 separate separate JJ cord-026384-ejk9wjr1 97 5 , , , cord-026384-ejk9wjr1 97 6 large large JJ cord-026384-ejk9wjr1 97 7 cohort cohort NN cord-026384-ejk9wjr1 97 8 in in IN cord-026384-ejk9wjr1 97 9 which which WDT cord-026384-ejk9wjr1 97 10 the the DT cord-026384-ejk9wjr1 97 11 definition definition NN cord-026384-ejk9wjr1 97 12 of of IN cord-026384-ejk9wjr1 97 13 poor poor JJ cord-026384-ejk9wjr1 97 14 outcome outcome NN cord-026384-ejk9wjr1 97 15 was be VBD cord-026384-ejk9wjr1 97 16 expanded expand VBN cord-026384-ejk9wjr1 97 17 from from IN cord-026384-ejk9wjr1 97 18 solely solely RB cord-026384-ejk9wjr1 97 19 NDI NDI NNP cord-026384-ejk9wjr1 97 20 to to IN cord-026384-ejk9wjr1 97 21 " " `` cord-026384-ejk9wjr1 97 22 poor poor JJ cord-026384-ejk9wjr1 97 23 general general JJ cord-026384-ejk9wjr1 97 24 health health NN cord-026384-ejk9wjr1 97 25 . . . cord-026384-ejk9wjr1 98 1 " " '' cord-026384-ejk9wjr1 99 1 33 33 CD cord-026384-ejk9wjr1 99 2 , , , cord-026384-ejk9wjr1 99 3 34 34 CD cord-026384-ejk9wjr1 99 4 Letting let VBG cord-026384-ejk9wjr1 99 5 the the DT cord-026384-ejk9wjr1 99 6 machines machine NNS cord-026384-ejk9wjr1 99 7 decide decide VB cord-026384-ejk9wjr1 99 8 Some some DT cord-026384-ejk9wjr1 99 9 innovative innovative JJ cord-026384-ejk9wjr1 99 10 work work NN cord-026384-ejk9wjr1 99 11 has have VBZ cord-026384-ejk9wjr1 99 12 been be VBN cord-026384-ejk9wjr1 99 13 recently recently RB cord-026384-ejk9wjr1 99 14 performed perform VBN cord-026384-ejk9wjr1 99 15 by by IN cord-026384-ejk9wjr1 99 16 Ambalavanan Ambalavanan NNP cord-026384-ejk9wjr1 99 17 et et NNP cord-026384-ejk9wjr1 99 18 al al NNP cord-026384-ejk9wjr1 99 19 . . . cord-026384-ejk9wjr1 100 1 14 14 CD cord-026384-ejk9wjr1 100 2 , , , cord-026384-ejk9wjr1 100 3 35 35 CD cord-026384-ejk9wjr1 100 4 in in IN cord-026384-ejk9wjr1 100 5 creating create VBG cord-026384-ejk9wjr1 100 6 several several JJ cord-026384-ejk9wjr1 100 7 risk risk NN cord-026384-ejk9wjr1 100 8 prediction prediction NN cord-026384-ejk9wjr1 100 9 models model NNS cord-026384-ejk9wjr1 100 10 . . . cord-026384-ejk9wjr1 101 1 45 45 CD cord-026384-ejk9wjr1 102 1 Along along IN cord-026384-ejk9wjr1 102 2 with with IN cord-026384-ejk9wjr1 102 3 studies study NNS cord-026384-ejk9wjr1 102 4 developing develop VBG cord-026384-ejk9wjr1 102 5 risk risk NN cord-026384-ejk9wjr1 102 6 prediction prediction NN cord-026384-ejk9wjr1 102 7 tools tool NNS cord-026384-ejk9wjr1 102 8 with with IN cord-026384-ejk9wjr1 102 9 data datum NNS cord-026384-ejk9wjr1 102 10 from from IN cord-026384-ejk9wjr1 102 11 the the DT cord-026384-ejk9wjr1 102 12 NRN NRN NNP cord-026384-ejk9wjr1 102 13 and and CC cord-026384-ejk9wjr1 102 14 the the DT cord-026384-ejk9wjr1 102 15 TIPP TIPP NNP cord-026384-ejk9wjr1 102 16 to to TO cord-026384-ejk9wjr1 102 17 predict predict VB cord-026384-ejk9wjr1 102 18 the the DT cord-026384-ejk9wjr1 102 19 outcomes outcome NNS cord-026384-ejk9wjr1 102 20 of of IN cord-026384-ejk9wjr1 102 21 death death NN cord-026384-ejk9wjr1 102 22 and and CC cord-026384-ejk9wjr1 102 23 NDI NDI NNP cord-026384-ejk9wjr1 102 24 or or CC cord-026384-ejk9wjr1 102 25 solely solely RB cord-026384-ejk9wjr1 102 26 NDI NDI NNP cord-026384-ejk9wjr1 102 27 , , , cord-026384-ejk9wjr1 102 28 the the DT cord-026384-ejk9wjr1 102 29 group group NN cord-026384-ejk9wjr1 102 30 made make VBD cord-026384-ejk9wjr1 102 31 the the DT cord-026384-ejk9wjr1 102 32 only only JJ cord-026384-ejk9wjr1 102 33 risk risk NN cord-026384-ejk9wjr1 102 34 prediction prediction NN cord-026384-ejk9wjr1 102 35 tool tool NN cord-026384-ejk9wjr1 102 36 for for IN cord-026384-ejk9wjr1 102 37 the the DT cord-026384-ejk9wjr1 102 38 outcome outcome NN cord-026384-ejk9wjr1 102 39 of of IN cord-026384-ejk9wjr1 102 40 rehospitalization rehospitalization NN cord-026384-ejk9wjr1 102 41 , , , cord-026384-ejk9wjr1 102 42 both both CC cord-026384-ejk9wjr1 102 43 general general JJ cord-026384-ejk9wjr1 102 44 and and CC cord-026384-ejk9wjr1 102 45 specifically specifically RB cord-026384-ejk9wjr1 102 46 for for IN cord-026384-ejk9wjr1 102 47 respiratory respiratory JJ cord-026384-ejk9wjr1 102 48 complications complication NNS cord-026384-ejk9wjr1 102 49 , , , cord-026384-ejk9wjr1 102 50 using use VBG cord-026384-ejk9wjr1 102 51 a a DT cord-026384-ejk9wjr1 102 52 combination combination NN cord-026384-ejk9wjr1 102 53 of of IN cord-026384-ejk9wjr1 102 54 physiologic physiologic JJ cord-026384-ejk9wjr1 102 55 and and CC cord-026384-ejk9wjr1 102 56 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 102 57 variables variable NNS cord-026384-ejk9wjr1 102 58 incorporated incorporate VBN cord-026384-ejk9wjr1 102 59 into into IN cord-026384-ejk9wjr1 102 60 a a DT cord-026384-ejk9wjr1 102 61 decision decision NN cord-026384-ejk9wjr1 102 62 tree tree NN cord-026384-ejk9wjr1 102 63 approach approach NN cord-026384-ejk9wjr1 102 64 . . . cord-026384-ejk9wjr1 103 1 They -PRON- PRP cord-026384-ejk9wjr1 103 2 have have VBP cord-026384-ejk9wjr1 103 3 also also RB cord-026384-ejk9wjr1 103 4 been be VBN cord-026384-ejk9wjr1 103 5 the the DT cord-026384-ejk9wjr1 103 6 only only JJ cord-026384-ejk9wjr1 103 7 group group NN cord-026384-ejk9wjr1 103 8 to to TO cord-026384-ejk9wjr1 103 9 create create VB cord-026384-ejk9wjr1 103 10 neural neural JJ cord-026384-ejk9wjr1 103 11 network network NN cord-026384-ejk9wjr1 103 12 - - HYPH cord-026384-ejk9wjr1 103 13 trained train VBN cord-026384-ejk9wjr1 103 14 models model NNS cord-026384-ejk9wjr1 103 15 , , , cord-026384-ejk9wjr1 103 16 using use VBG cord-026384-ejk9wjr1 103 17 the the DT cord-026384-ejk9wjr1 103 18 same same JJ cord-026384-ejk9wjr1 103 19 small small JJ cord-026384-ejk9wjr1 103 20 cohort cohort NN cord-026384-ejk9wjr1 103 21 to to TO cord-026384-ejk9wjr1 103 22 predict predict VB cord-026384-ejk9wjr1 103 23 major major JJ cord-026384-ejk9wjr1 103 24 handicap handicap NN cord-026384-ejk9wjr1 103 25 , , , cord-026384-ejk9wjr1 103 26 low low JJ cord-026384-ejk9wjr1 103 27 mental mental JJ cord-026384-ejk9wjr1 103 28 development development NN cord-026384-ejk9wjr1 103 29 index index NN cord-026384-ejk9wjr1 103 30 ( ( -LRB- cord-026384-ejk9wjr1 103 31 MDI MDI NNP cord-026384-ejk9wjr1 103 32 ) ) -RRB- cord-026384-ejk9wjr1 103 33 , , , cord-026384-ejk9wjr1 103 34 or or CC cord-026384-ejk9wjr1 103 35 low low JJ cord-026384-ejk9wjr1 103 36 psychomotor psychomotor NN cord-026384-ejk9wjr1 103 37 development development NN cord-026384-ejk9wjr1 103 38 index index NN cord-026384-ejk9wjr1 103 39 ( ( -LRB- cord-026384-ejk9wjr1 103 40 PDI PDI NNP cord-026384-ejk9wjr1 103 41 ) ) -RRB- cord-026384-ejk9wjr1 103 42 . . . cord-026384-ejk9wjr1 104 1 The the DT cord-026384-ejk9wjr1 104 2 advantage advantage NN cord-026384-ejk9wjr1 104 3 of of IN cord-026384-ejk9wjr1 104 4 using use VBG cord-026384-ejk9wjr1 104 5 neural neural JJ cord-026384-ejk9wjr1 104 6 networks network NNS cord-026384-ejk9wjr1 104 7 - - , cord-026384-ejk9wjr1 104 8 algorithms algorithm NNS cord-026384-ejk9wjr1 104 9 that that WDT cord-026384-ejk9wjr1 104 10 can can MD cord-026384-ejk9wjr1 104 11 " " `` cord-026384-ejk9wjr1 104 12 learn learn VB cord-026384-ejk9wjr1 104 13 " " `` cord-026384-ejk9wjr1 104 14 mathematical mathematical JJ cord-026384-ejk9wjr1 104 15 relationships relationship NNS cord-026384-ejk9wjr1 104 16 between between IN cord-026384-ejk9wjr1 104 17 a a DT cord-026384-ejk9wjr1 104 18 series series NN cord-026384-ejk9wjr1 104 19 of of IN cord-026384-ejk9wjr1 104 20 independent independent JJ cord-026384-ejk9wjr1 104 21 variables variable NNS cord-026384-ejk9wjr1 104 22 and and CC cord-026384-ejk9wjr1 104 23 a a DT cord-026384-ejk9wjr1 104 24 set set NN cord-026384-ejk9wjr1 104 25 of of IN cord-026384-ejk9wjr1 104 26 outcomes outcome NNS cord-026384-ejk9wjr1 104 27 - - : cord-026384-ejk9wjr1 104 28 is be VBZ cord-026384-ejk9wjr1 104 29 the the DT cord-026384-ejk9wjr1 104 30 ability ability NN cord-026384-ejk9wjr1 104 31 to to TO cord-026384-ejk9wjr1 104 32 model model VB cord-026384-ejk9wjr1 104 33 complex complex JJ cord-026384-ejk9wjr1 104 34 or or CC cord-026384-ejk9wjr1 104 35 nonlinear nonlinear JJ cord-026384-ejk9wjr1 104 36 relationships relationship NNS cord-026384-ejk9wjr1 104 37 that that WDT cord-026384-ejk9wjr1 104 38 can can MD cord-026384-ejk9wjr1 104 39 be be VB cord-026384-ejk9wjr1 104 40 elucidated elucidate VBN cord-026384-ejk9wjr1 104 41 by by IN cord-026384-ejk9wjr1 104 42 the the DT cord-026384-ejk9wjr1 104 43 model model NN cord-026384-ejk9wjr1 104 44 without without IN cord-026384-ejk9wjr1 104 45 having have VBG cord-026384-ejk9wjr1 104 46 to to TO cord-026384-ejk9wjr1 104 47 consider consider VB cord-026384-ejk9wjr1 104 48 these these DT cord-026384-ejk9wjr1 104 49 relationships relationship NNS cord-026384-ejk9wjr1 104 50 a a DT cord-026384-ejk9wjr1 104 51 priori priori FW cord-026384-ejk9wjr1 104 52 ( ( -LRB- cord-026384-ejk9wjr1 104 53 as as IN cord-026384-ejk9wjr1 104 54 is be VBZ cord-026384-ejk9wjr1 104 55 typically typically RB cord-026384-ejk9wjr1 104 56 required require VBN cord-026384-ejk9wjr1 104 57 when when WRB cord-026384-ejk9wjr1 104 58 using use VBG cord-026384-ejk9wjr1 104 59 multiple multiple JJ cord-026384-ejk9wjr1 104 60 regression regression NN cord-026384-ejk9wjr1 104 61 models model NNS cord-026384-ejk9wjr1 104 62 ) ) -RRB- cord-026384-ejk9wjr1 104 63 . . . cord-026384-ejk9wjr1 105 1 Despite despite IN cord-026384-ejk9wjr1 105 2 the the DT cord-026384-ejk9wjr1 105 3 use use NN cord-026384-ejk9wjr1 105 4 of of IN cord-026384-ejk9wjr1 105 5 innovative innovative JJ cord-026384-ejk9wjr1 105 6 approaches approach NNS cord-026384-ejk9wjr1 105 7 , , , cord-026384-ejk9wjr1 105 8 however however RB cord-026384-ejk9wjr1 105 9 , , , cord-026384-ejk9wjr1 105 10 none none NN cord-026384-ejk9wjr1 105 11 of of IN cord-026384-ejk9wjr1 105 12 these these DT cord-026384-ejk9wjr1 105 13 models model NNS cord-026384-ejk9wjr1 105 14 differed differ VBD cord-026384-ejk9wjr1 105 15 from from IN cord-026384-ejk9wjr1 105 16 other other JJ cord-026384-ejk9wjr1 105 17 studies study NNS cord-026384-ejk9wjr1 105 18 in in IN cord-026384-ejk9wjr1 105 19 predictive predictive JJ cord-026384-ejk9wjr1 105 20 strength strength NN cord-026384-ejk9wjr1 105 21 or or CC cord-026384-ejk9wjr1 105 22 even even RB cord-026384-ejk9wjr1 105 23 had have VBD cord-026384-ejk9wjr1 105 24 high high JJ cord-026384-ejk9wjr1 105 25 predictive predictive JJ cord-026384-ejk9wjr1 105 26 efficacy efficacy NN cord-026384-ejk9wjr1 105 27 . . . cord-026384-ejk9wjr1 106 1 31 31 CD cord-026384-ejk9wjr1 106 2 Limitations limitation NNS cord-026384-ejk9wjr1 106 3 of of IN cord-026384-ejk9wjr1 106 4 prior prior JJ cord-026384-ejk9wjr1 106 5 approaches approach NNS cord-026384-ejk9wjr1 107 1 The the DT cord-026384-ejk9wjr1 107 2 above above JJ cord-026384-ejk9wjr1 107 3 literature literature NN cord-026384-ejk9wjr1 107 4 review review NN cord-026384-ejk9wjr1 107 5 highlights highlight VBZ cord-026384-ejk9wjr1 107 6 the the DT cord-026384-ejk9wjr1 107 7 substantial substantial JJ cord-026384-ejk9wjr1 107 8 interest interest NN cord-026384-ejk9wjr1 107 9 in in IN cord-026384-ejk9wjr1 107 10 developing develop VBG cord-026384-ejk9wjr1 107 11 a a DT cord-026384-ejk9wjr1 107 12 clinically clinically RB cord-026384-ejk9wjr1 107 13 useful useful JJ cord-026384-ejk9wjr1 107 14 risk risk NN cord-026384-ejk9wjr1 107 15 prediction prediction NN cord-026384-ejk9wjr1 107 16 model model NN cord-026384-ejk9wjr1 107 17 and and CC cord-026384-ejk9wjr1 107 18 the the DT cord-026384-ejk9wjr1 107 19 limits limit NNS cord-026384-ejk9wjr1 107 20 of of IN cord-026384-ejk9wjr1 107 21 efforts effort NNS cord-026384-ejk9wjr1 107 22 to to IN cord-026384-ejk9wjr1 107 23 date date NN cord-026384-ejk9wjr1 107 24 . . . cord-026384-ejk9wjr1 108 1 Notwithstanding notwithstanding IN cord-026384-ejk9wjr1 108 2 their -PRON- PRP$ cord-026384-ejk9wjr1 108 3 differing differ VBG cord-026384-ejk9wjr1 108 4 inclusion inclusion NN cord-026384-ejk9wjr1 108 5 and and CC cord-026384-ejk9wjr1 108 6 exclusion exclusion NN cord-026384-ejk9wjr1 108 7 criteria criterion NNS cord-026384-ejk9wjr1 108 8 , , , cord-026384-ejk9wjr1 108 9 existing exist VBG cord-026384-ejk9wjr1 108 10 risk risk NN cord-026384-ejk9wjr1 108 11 prediction prediction NN cord-026384-ejk9wjr1 108 12 models model NNS cord-026384-ejk9wjr1 108 13 are be VBP cord-026384-ejk9wjr1 108 14 relatively relatively RB cord-026384-ejk9wjr1 108 15 similar similar JJ cord-026384-ejk9wjr1 108 16 in in IN cord-026384-ejk9wjr1 108 17 terms term NNS cord-026384-ejk9wjr1 108 18 of of IN cord-026384-ejk9wjr1 108 19 variables variable NNS cord-026384-ejk9wjr1 108 20 selected select VBN cord-026384-ejk9wjr1 108 21 , , , cord-026384-ejk9wjr1 108 22 outcomes outcome NNS cord-026384-ejk9wjr1 108 23 analyzed analyze VBN cord-026384-ejk9wjr1 108 24 , , , cord-026384-ejk9wjr1 108 25 and and CC cord-026384-ejk9wjr1 108 26 statistical statistical JJ cord-026384-ejk9wjr1 108 27 strategies strategy NNS cord-026384-ejk9wjr1 108 28 employed employ VBN cord-026384-ejk9wjr1 108 29 . . . cord-026384-ejk9wjr1 109 1 With with IN cord-026384-ejk9wjr1 109 2 few few JJ cord-026384-ejk9wjr1 109 3 exceptions exception NNS cord-026384-ejk9wjr1 109 4 , , , cord-026384-ejk9wjr1 109 5 the the DT cord-026384-ejk9wjr1 109 6 limitations limitation NNS cord-026384-ejk9wjr1 109 7 of of IN cord-026384-ejk9wjr1 109 8 existing exist VBG cord-026384-ejk9wjr1 109 9 risk risk NN cord-026384-ejk9wjr1 109 10 prediction prediction NN cord-026384-ejk9wjr1 109 11 models model NNS cord-026384-ejk9wjr1 109 12 are be VBP cord-026384-ejk9wjr1 109 13 especially especially RB cord-026384-ejk9wjr1 109 14 apparent apparent JJ cord-026384-ejk9wjr1 109 15 in in IN cord-026384-ejk9wjr1 109 16 their -PRON- PRP$ cord-026384-ejk9wjr1 109 17 reliance reliance NN cord-026384-ejk9wjr1 109 18 on on IN cord-026384-ejk9wjr1 109 19 solely solely RB cord-026384-ejk9wjr1 109 20 biologic biologic JJ cord-026384-ejk9wjr1 109 21 variables variable NNS cord-026384-ejk9wjr1 109 22 and and CC cord-026384-ejk9wjr1 109 23 traditional traditional JJ cord-026384-ejk9wjr1 109 24 analytic analytic JJ cord-026384-ejk9wjr1 109 25 methods method NNS cord-026384-ejk9wjr1 109 26 ill ill RB cord-026384-ejk9wjr1 109 27 - - HYPH cord-026384-ejk9wjr1 109 28 equipped equipped JJ cord-026384-ejk9wjr1 109 29 to to TO cord-026384-ejk9wjr1 109 30 handle handle VB cord-026384-ejk9wjr1 109 31 the the DT cord-026384-ejk9wjr1 109 32 statistical statistical JJ cord-026384-ejk9wjr1 109 33 complexity complexity NN cord-026384-ejk9wjr1 109 34 necessary necessary JJ cord-026384-ejk9wjr1 109 35 for for IN cord-026384-ejk9wjr1 109 36 risk risk NN cord-026384-ejk9wjr1 109 37 modeling modeling NN cord-026384-ejk9wjr1 109 38 . . . cord-026384-ejk9wjr1 110 1 Identifying identify VBG cord-026384-ejk9wjr1 110 2 important important JJ cord-026384-ejk9wjr1 110 3 outcomes outcome NNS cord-026384-ejk9wjr1 110 4 . . . cord-026384-ejk9wjr1 111 1 The the DT cord-026384-ejk9wjr1 111 2 majority majority NN cord-026384-ejk9wjr1 111 3 of of IN cord-026384-ejk9wjr1 111 4 risk risk NN cord-026384-ejk9wjr1 111 5 prediction prediction NN cord-026384-ejk9wjr1 111 6 models model NNS cord-026384-ejk9wjr1 111 7 defined define VBD cord-026384-ejk9wjr1 111 8 NDI NDI NNP cord-026384-ejk9wjr1 111 9 as as IN cord-026384-ejk9wjr1 111 10 their -PRON- PRP$ cord-026384-ejk9wjr1 111 11 primary primary JJ cord-026384-ejk9wjr1 111 12 outcome outcome NN cord-026384-ejk9wjr1 111 13 of of IN cord-026384-ejk9wjr1 111 14 interest interest NN cord-026384-ejk9wjr1 111 15 . . . cord-026384-ejk9wjr1 112 1 Making make VBG cord-026384-ejk9wjr1 112 2 a a DT cord-026384-ejk9wjr1 112 3 determination determination NN cord-026384-ejk9wjr1 112 4 of of IN cord-026384-ejk9wjr1 112 5 impairment impairment NN cord-026384-ejk9wjr1 112 6 often often RB cord-026384-ejk9wjr1 112 7 relies rely VBZ cord-026384-ejk9wjr1 112 8 on on IN cord-026384-ejk9wjr1 112 9 standardized standardized JJ cord-026384-ejk9wjr1 112 10 measures measure NNS cord-026384-ejk9wjr1 112 11 of of IN cord-026384-ejk9wjr1 112 12 cognition cognition NN cord-026384-ejk9wjr1 112 13 in in IN cord-026384-ejk9wjr1 112 14 concert concert NN cord-026384-ejk9wjr1 112 15 with with IN cord-026384-ejk9wjr1 112 16 neurosensory neurosensory JJ cord-026384-ejk9wjr1 112 17 deficits deficit NNS cord-026384-ejk9wjr1 112 18 . . . cord-026384-ejk9wjr1 113 1 Yet yet RB cord-026384-ejk9wjr1 113 2 , , , cord-026384-ejk9wjr1 113 3 researchers researcher NNS cord-026384-ejk9wjr1 113 4 often often RB cord-026384-ejk9wjr1 113 5 define define VBP cord-026384-ejk9wjr1 113 6 NDI NDI NNP cord-026384-ejk9wjr1 113 7 in in IN cord-026384-ejk9wjr1 113 8 different different JJ cord-026384-ejk9wjr1 113 9 ways way NNS cord-026384-ejk9wjr1 113 10 , , , cord-026384-ejk9wjr1 113 11 making make VBG cord-026384-ejk9wjr1 113 12 betweenstudy betweenstudy NN cord-026384-ejk9wjr1 113 13 comparisons comparison NNS cord-026384-ejk9wjr1 113 14 difficult difficult JJ cord-026384-ejk9wjr1 113 15 . . . cord-026384-ejk9wjr1 114 1 NDI NDI NNP cord-026384-ejk9wjr1 114 2 is be VBZ cord-026384-ejk9wjr1 114 3 a a DT cord-026384-ejk9wjr1 114 4 construct construct NN cord-026384-ejk9wjr1 114 5 relating relate VBG cord-026384-ejk9wjr1 114 6 to to IN cord-026384-ejk9wjr1 114 7 global global JJ cord-026384-ejk9wjr1 114 8 abilities ability NNS cord-026384-ejk9wjr1 114 9 encompassing encompass VBG cord-026384-ejk9wjr1 114 10 cognition cognition NN cord-026384-ejk9wjr1 114 11 , , , cord-026384-ejk9wjr1 114 12 language language NN cord-026384-ejk9wjr1 114 13 , , , cord-026384-ejk9wjr1 114 14 motor motor NN cord-026384-ejk9wjr1 114 15 function function NN cord-026384-ejk9wjr1 114 16 , , , cord-026384-ejk9wjr1 114 17 and and CC cord-026384-ejk9wjr1 114 18 vision vision NN cord-026384-ejk9wjr1 114 19 and and CC cord-026384-ejk9wjr1 114 20 hearing hearing NN cord-026384-ejk9wjr1 114 21 . . . cord-026384-ejk9wjr1 115 1 While while IN cord-026384-ejk9wjr1 115 2 the the DT cord-026384-ejk9wjr1 115 3 tools tool NNS cord-026384-ejk9wjr1 115 4 used use VBN cord-026384-ejk9wjr1 115 5 to to TO cord-026384-ejk9wjr1 115 6 identify identify VB cord-026384-ejk9wjr1 115 7 NDI NDI NNP cord-026384-ejk9wjr1 115 8 are be VBP cord-026384-ejk9wjr1 115 9 often often RB cord-026384-ejk9wjr1 115 10 also also RB cord-026384-ejk9wjr1 115 11 used use VBN cord-026384-ejk9wjr1 115 12 to to TO cord-026384-ejk9wjr1 115 13 make make VB cord-026384-ejk9wjr1 115 14 diagnoses diagnosis NNS cord-026384-ejk9wjr1 115 15 of of IN cord-026384-ejk9wjr1 115 16 developmental developmental JJ cord-026384-ejk9wjr1 115 17 delay delay NN cord-026384-ejk9wjr1 115 18 , , , cord-026384-ejk9wjr1 115 19 NDI NDI NNP cord-026384-ejk9wjr1 115 20 is be VBZ cord-026384-ejk9wjr1 115 21 not not RB cord-026384-ejk9wjr1 115 22 a a DT cord-026384-ejk9wjr1 115 23 clinical clinical JJ cord-026384-ejk9wjr1 115 24 term term NN cord-026384-ejk9wjr1 115 25 or or CC cord-026384-ejk9wjr1 115 26 diagnosis diagnosis NN cord-026384-ejk9wjr1 115 27 in in IN cord-026384-ejk9wjr1 115 28 and and CC cord-026384-ejk9wjr1 115 29 of of IN cord-026384-ejk9wjr1 115 30 itself -PRON- PRP cord-026384-ejk9wjr1 115 31 . . . cord-026384-ejk9wjr1 116 1 Many many JJ cord-026384-ejk9wjr1 116 2 of of IN cord-026384-ejk9wjr1 116 3 the the DT cord-026384-ejk9wjr1 116 4 remaining remain VBG cord-026384-ejk9wjr1 116 5 studies study NNS cord-026384-ejk9wjr1 116 6 also also RB cord-026384-ejk9wjr1 116 7 predicted predict VBD cord-026384-ejk9wjr1 116 8 functional functional JJ cord-026384-ejk9wjr1 116 9 outcomes outcome NNS cord-026384-ejk9wjr1 116 10 , , , cord-026384-ejk9wjr1 116 11 such such JJ cord-026384-ejk9wjr1 116 12 as as IN cord-026384-ejk9wjr1 116 13 academic academic JJ cord-026384-ejk9wjr1 116 14 performance performance NN cord-026384-ejk9wjr1 116 15 , , , cord-026384-ejk9wjr1 116 16 executive executive JJ cord-026384-ejk9wjr1 116 17 function function NN cord-026384-ejk9wjr1 116 18 , , , cord-026384-ejk9wjr1 116 19 language language NN cord-026384-ejk9wjr1 116 20 ability ability NN cord-026384-ejk9wjr1 116 21 , , , cord-026384-ejk9wjr1 116 22 and and CC cord-026384-ejk9wjr1 116 23 autism autism NN cord-026384-ejk9wjr1 116 24 spectrum spectrum NN cord-026384-ejk9wjr1 116 25 disorder disorder NN cord-026384-ejk9wjr1 116 26 ( ( -LRB- cord-026384-ejk9wjr1 116 27 ASD ASD NNP cord-026384-ejk9wjr1 116 28 ) ) -RRB- cord-026384-ejk9wjr1 116 29 . . . cord-026384-ejk9wjr1 117 1 These these DT cord-026384-ejk9wjr1 117 2 outcomes outcome NNS cord-026384-ejk9wjr1 117 3 may may MD cord-026384-ejk9wjr1 117 4 be be VB cord-026384-ejk9wjr1 117 5 more more RBR cord-026384-ejk9wjr1 117 6 meaningful meaningful JJ cord-026384-ejk9wjr1 117 7 to to IN cord-026384-ejk9wjr1 117 8 parents parent NNS cord-026384-ejk9wjr1 117 9 and and CC cord-026384-ejk9wjr1 117 10 providers provider NNS cord-026384-ejk9wjr1 117 11 than than IN cord-026384-ejk9wjr1 117 12 NDI NDI NNP cord-026384-ejk9wjr1 117 13 . . . cord-026384-ejk9wjr1 118 1 54 54 CD cord-026384-ejk9wjr1 119 1 To to IN cord-026384-ejk9wjr1 119 2 date date NN cord-026384-ejk9wjr1 119 3 , , , cord-026384-ejk9wjr1 119 4 only only RB cord-026384-ejk9wjr1 119 5 four four CD cord-026384-ejk9wjr1 119 6 studies study NNS cord-026384-ejk9wjr1 119 7 have have VBP cord-026384-ejk9wjr1 119 8 considered consider VBN cord-026384-ejk9wjr1 119 9 outcomes outcome NNS cord-026384-ejk9wjr1 119 10 unrelated unrelated JJ cord-026384-ejk9wjr1 119 11 to to IN cord-026384-ejk9wjr1 119 12 neurodevelopment neurodevelopment NN cord-026384-ejk9wjr1 119 13 , , , cord-026384-ejk9wjr1 119 14 such such JJ cord-026384-ejk9wjr1 119 15 as as IN cord-026384-ejk9wjr1 119 16 impaired impaired JJ cord-026384-ejk9wjr1 119 17 pulmonary pulmonary JJ cord-026384-ejk9wjr1 119 18 function function NN cord-026384-ejk9wjr1 119 19 , , , cord-026384-ejk9wjr1 119 20 " " '' cord-026384-ejk9wjr1 119 21 poor poor JJ cord-026384-ejk9wjr1 119 22 general general JJ cord-026384-ejk9wjr1 119 23 health health NN cord-026384-ejk9wjr1 119 24 , , , cord-026384-ejk9wjr1 119 25 " " '' cord-026384-ejk9wjr1 119 26 and and CC cord-026384-ejk9wjr1 119 27 rehospitalization rehospitalization NN cord-026384-ejk9wjr1 119 28 rates rate NNS cord-026384-ejk9wjr1 119 29 . . . cord-026384-ejk9wjr1 120 1 15 15 CD cord-026384-ejk9wjr1 120 2 , , , cord-026384-ejk9wjr1 120 3 28 28 CD cord-026384-ejk9wjr1 120 4 , , , cord-026384-ejk9wjr1 120 5 45 45 CD cord-026384-ejk9wjr1 120 6 , , , cord-026384-ejk9wjr1 120 7 49 49 CD cord-026384-ejk9wjr1 120 8 While while IN cord-026384-ejk9wjr1 120 9 the the DT cord-026384-ejk9wjr1 120 10 emphasis emphasis NN cord-026384-ejk9wjr1 120 11 on on IN cord-026384-ejk9wjr1 120 12 NDI NDI NNP cord-026384-ejk9wjr1 120 13 is be VBZ cord-026384-ejk9wjr1 120 14 unsurprising unsurprising JJ cord-026384-ejk9wjr1 120 15 given give VBN cord-026384-ejk9wjr1 120 16 the the DT cord-026384-ejk9wjr1 120 17 high high JJ cord-026384-ejk9wjr1 120 18 - - HYPH cord-026384-ejk9wjr1 120 19 risk risk NN cord-026384-ejk9wjr1 120 20 population population NN cord-026384-ejk9wjr1 120 21 , , , cord-026384-ejk9wjr1 120 22 moderate moderate JJ cord-026384-ejk9wjr1 120 23 to to IN cord-026384-ejk9wjr1 120 24 severe severe JJ cord-026384-ejk9wjr1 120 25 NDI NDI NNP cord-026384-ejk9wjr1 120 26 only only RB cord-026384-ejk9wjr1 120 27 affects affect VBZ cord-026384-ejk9wjr1 120 28 a a DT cord-026384-ejk9wjr1 120 29 minority minority NN cord-026384-ejk9wjr1 120 30 of of IN cord-026384-ejk9wjr1 120 31 the the DT cord-026384-ejk9wjr1 120 32 preterm preterm JJ cord-026384-ejk9wjr1 120 33 population population NN cord-026384-ejk9wjr1 120 34 . . . cord-026384-ejk9wjr1 121 1 55 55 CD cord-026384-ejk9wjr1 121 2 , , , cord-026384-ejk9wjr1 121 3 56 56 CD cord-026384-ejk9wjr1 121 4 Studies study NNS cord-026384-ejk9wjr1 121 5 have have VBP cord-026384-ejk9wjr1 121 6 revealed reveal VBN cord-026384-ejk9wjr1 121 7 numerous numerous JJ cord-026384-ejk9wjr1 121 8 additional additional JJ cord-026384-ejk9wjr1 121 9 adverse adverse JJ cord-026384-ejk9wjr1 121 10 outcomes outcome NNS cord-026384-ejk9wjr1 121 11 that that WDT cord-026384-ejk9wjr1 121 12 preterm preterm JJR cord-026384-ejk9wjr1 121 13 individuals individual NNS cord-026384-ejk9wjr1 121 14 are be VBP cord-026384-ejk9wjr1 121 15 more more RBR cord-026384-ejk9wjr1 121 16 likely likely JJ cord-026384-ejk9wjr1 121 17 to to TO cord-026384-ejk9wjr1 121 18 experience experience VB cord-026384-ejk9wjr1 121 19 compared compare VBN cord-026384-ejk9wjr1 121 20 to to IN cord-026384-ejk9wjr1 121 21 their -PRON- PRP$ cord-026384-ejk9wjr1 121 22 full full JJ cord-026384-ejk9wjr1 121 23 - - HYPH cord-026384-ejk9wjr1 121 24 term term NN cord-026384-ejk9wjr1 121 25 counterparts counterpart NNS cord-026384-ejk9wjr1 121 26 , , , cord-026384-ejk9wjr1 121 27 such such JJ cord-026384-ejk9wjr1 121 28 as as IN cord-026384-ejk9wjr1 121 29 impaired impaired JJ cord-026384-ejk9wjr1 121 30 respiratory respiratory JJ cord-026384-ejk9wjr1 121 31 , , , cord-026384-ejk9wjr1 121 32 cardiovascular cardiovascular JJ cord-026384-ejk9wjr1 121 33 , , , cord-026384-ejk9wjr1 121 34 and and CC cord-026384-ejk9wjr1 121 35 metabolic metabolic JJ cord-026384-ejk9wjr1 121 36 function function NN cord-026384-ejk9wjr1 121 37 . . . cord-026384-ejk9wjr1 122 1 [ [ -LRB- cord-026384-ejk9wjr1 122 2 57 57 CD cord-026384-ejk9wjr1 122 3 ] ] -RRB- cord-026384-ejk9wjr1 122 4 [ [ -LRB- cord-026384-ejk9wjr1 122 5 58 58 CD cord-026384-ejk9wjr1 122 6 ] ] -RRB- cord-026384-ejk9wjr1 123 1 [ [ -LRB- cord-026384-ejk9wjr1 123 2 59 59 CD cord-026384-ejk9wjr1 123 3 ] ] -RRB- cord-026384-ejk9wjr1 123 4 [ [ -LRB- cord-026384-ejk9wjr1 123 5 60 60 CD cord-026384-ejk9wjr1 123 6 ] ] -RRB- cord-026384-ejk9wjr1 123 7 [ [ -LRB- cord-026384-ejk9wjr1 123 8 61 61 CD cord-026384-ejk9wjr1 123 9 ] ] -RRB- cord-026384-ejk9wjr1 124 1 [ [ -LRB- cord-026384-ejk9wjr1 124 2 62 62 CD cord-026384-ejk9wjr1 124 3 ] ] -RRB- cord-026384-ejk9wjr1 124 4 [ [ -LRB- cord-026384-ejk9wjr1 124 5 63 63 CD cord-026384-ejk9wjr1 124 6 ] ] -RRB- cord-026384-ejk9wjr1 125 1 [ [ -LRB- cord-026384-ejk9wjr1 125 2 64 64 CD cord-026384-ejk9wjr1 125 3 ] ] -RRB- cord-026384-ejk9wjr1 126 1 [ [ -LRB- cord-026384-ejk9wjr1 126 2 65 65 CD cord-026384-ejk9wjr1 126 3 ] ] -RRB- cord-026384-ejk9wjr1 127 1 [ [ -LRB- cord-026384-ejk9wjr1 127 2 66 66 CD cord-026384-ejk9wjr1 127 3 ] ] -RRB- cord-026384-ejk9wjr1 128 1 Neurodevelopment Neurodevelopment NNP cord-026384-ejk9wjr1 128 2 has have VBZ cord-026384-ejk9wjr1 128 3 been be VBN cord-026384-ejk9wjr1 128 4 linked link VBN cord-026384-ejk9wjr1 128 5 to to IN cord-026384-ejk9wjr1 128 6 chronic chronic JJ cord-026384-ejk9wjr1 128 7 health health NN cord-026384-ejk9wjr1 128 8 problems problem NNS cord-026384-ejk9wjr1 128 9 in in IN cord-026384-ejk9wjr1 128 10 later later JJ cord-026384-ejk9wjr1 128 11 childhood childhood NN cord-026384-ejk9wjr1 128 12 . . . cord-026384-ejk9wjr1 129 1 67 67 CD cord-026384-ejk9wjr1 130 1 Limiting limit VBG cord-026384-ejk9wjr1 130 2 risk risk NN cord-026384-ejk9wjr1 130 3 prediction prediction NN cord-026384-ejk9wjr1 130 4 to to TO cord-026384-ejk9wjr1 130 5 moderate moderate VB cord-026384-ejk9wjr1 130 6 to to IN cord-026384-ejk9wjr1 130 7 severe severe JJ cord-026384-ejk9wjr1 130 8 NDI NDI NNP cord-026384-ejk9wjr1 130 9 therefore therefore RB cord-026384-ejk9wjr1 130 10 ignores ignore VBZ cord-026384-ejk9wjr1 130 11 other other JJ cord-026384-ejk9wjr1 130 12 , , , cord-026384-ejk9wjr1 130 13 more more RBR cord-026384-ejk9wjr1 130 14 common common JJ cord-026384-ejk9wjr1 130 15 complications complication NNS cord-026384-ejk9wjr1 130 16 that that WDT cord-026384-ejk9wjr1 130 17 preterm preterm JJR cord-026384-ejk9wjr1 130 18 infants infant NNS cord-026384-ejk9wjr1 130 19 are be VBP cord-026384-ejk9wjr1 130 20 likely likely JJ cord-026384-ejk9wjr1 130 21 to to TO cord-026384-ejk9wjr1 130 22 face face VB cord-026384-ejk9wjr1 130 23 that that WDT cord-026384-ejk9wjr1 130 24 have have VBP cord-026384-ejk9wjr1 130 25 an an DT cord-026384-ejk9wjr1 130 26 impact impact NN cord-026384-ejk9wjr1 130 27 on on IN cord-026384-ejk9wjr1 130 28 neurodevelopment neurodevelopment NN cord-026384-ejk9wjr1 130 29 . . . cord-026384-ejk9wjr1 131 1 This this DT cord-026384-ejk9wjr1 131 2 represents represent VBZ cord-026384-ejk9wjr1 131 3 a a DT cord-026384-ejk9wjr1 131 4 missed missed JJ cord-026384-ejk9wjr1 131 5 opportunity opportunity NN cord-026384-ejk9wjr1 131 6 for for IN cord-026384-ejk9wjr1 131 7 researchers researcher NNS cord-026384-ejk9wjr1 131 8 to to TO cord-026384-ejk9wjr1 131 9 better better RB cord-026384-ejk9wjr1 131 10 understand understand VB cord-026384-ejk9wjr1 131 11 what what WP cord-026384-ejk9wjr1 131 12 variables variable NNS cord-026384-ejk9wjr1 131 13 influence influence VBP cord-026384-ejk9wjr1 131 14 the the DT cord-026384-ejk9wjr1 131 15 likelihood likelihood NN cord-026384-ejk9wjr1 131 16 that that IN cord-026384-ejk9wjr1 131 17 these these DT cord-026384-ejk9wjr1 131 18 problems problem NNS cord-026384-ejk9wjr1 131 19 occur occur VBP cord-026384-ejk9wjr1 131 20 . . . cord-026384-ejk9wjr1 132 1 The the DT cord-026384-ejk9wjr1 132 2 impact impact NN cord-026384-ejk9wjr1 132 3 of of IN cord-026384-ejk9wjr1 132 4 developmental developmental JJ cord-026384-ejk9wjr1 132 5 disability disability NN cord-026384-ejk9wjr1 132 6 on on IN cord-026384-ejk9wjr1 132 7 the the DT cord-026384-ejk9wjr1 132 8 child child NN cord-026384-ejk9wjr1 132 9 and and CC cord-026384-ejk9wjr1 132 10 family family NN cord-026384-ejk9wjr1 132 11 is be VBZ cord-026384-ejk9wjr1 132 12 completely completely RB cord-026384-ejk9wjr1 132 13 absent absent JJ cord-026384-ejk9wjr1 132 14 from from IN cord-026384-ejk9wjr1 132 15 current current JJ cord-026384-ejk9wjr1 132 16 risk risk NN cord-026384-ejk9wjr1 132 17 models model NNS cord-026384-ejk9wjr1 132 18 . . . cord-026384-ejk9wjr1 133 1 Health health NN cord-026384-ejk9wjr1 133 2 - - HYPH cord-026384-ejk9wjr1 133 3 related relate VBN cord-026384-ejk9wjr1 133 4 quality quality NN cord-026384-ejk9wjr1 133 5 of of IN cord-026384-ejk9wjr1 133 6 life life NN cord-026384-ejk9wjr1 133 7 ( ( -LRB- cord-026384-ejk9wjr1 133 8 HRQL HRQL NNP cord-026384-ejk9wjr1 133 9 ) ) -RRB- cord-026384-ejk9wjr1 133 10 , , , cord-026384-ejk9wjr1 133 11 which which WDT cord-026384-ejk9wjr1 133 12 distinguishes distinguish VBZ cord-026384-ejk9wjr1 133 13 itself -PRON- PRP cord-026384-ejk9wjr1 133 14 as as IN cord-026384-ejk9wjr1 133 15 a a DT cord-026384-ejk9wjr1 133 16 personal personal JJ cord-026384-ejk9wjr1 133 17 rather rather RB cord-026384-ejk9wjr1 133 18 than than IN cord-026384-ejk9wjr1 133 19 third third JJ cord-026384-ejk9wjr1 133 20 - - HYPH cord-026384-ejk9wjr1 133 21 party party NN cord-026384-ejk9wjr1 133 22 valuation valuation NN cord-026384-ejk9wjr1 133 23 of of IN cord-026384-ejk9wjr1 133 24 a a DT cord-026384-ejk9wjr1 133 25 patient patient NN cord-026384-ejk9wjr1 133 26 's 's POS cord-026384-ejk9wjr1 133 27 physical physical JJ cord-026384-ejk9wjr1 133 28 and and CC cord-026384-ejk9wjr1 133 29 emotional emotional JJ cord-026384-ejk9wjr1 133 30 well well NN cord-026384-ejk9wjr1 133 31 - - HYPH cord-026384-ejk9wjr1 133 32 being being NN cord-026384-ejk9wjr1 133 33 , , , cord-026384-ejk9wjr1 133 34 is be VBZ cord-026384-ejk9wjr1 133 35 being be VBG cord-026384-ejk9wjr1 133 36 increasingly increasingly RB cord-026384-ejk9wjr1 133 37 appreciated appreciate VBN cord-026384-ejk9wjr1 133 38 as as IN cord-026384-ejk9wjr1 133 39 an an DT cord-026384-ejk9wjr1 133 40 important important JJ cord-026384-ejk9wjr1 133 41 metric metric NN cord-026384-ejk9wjr1 133 42 necessary necessary JJ cord-026384-ejk9wjr1 133 43 to to TO cord-026384-ejk9wjr1 133 44 fully fully RB cord-026384-ejk9wjr1 133 45 understand understand VB cord-026384-ejk9wjr1 133 46 the the DT cord-026384-ejk9wjr1 133 47 impact impact NN cord-026384-ejk9wjr1 133 48 of of IN cord-026384-ejk9wjr1 133 49 prematurity prematurity NN cord-026384-ejk9wjr1 133 50 . . . cord-026384-ejk9wjr1 134 1 68 68 CD cord-026384-ejk9wjr1 135 1 In in IN cord-026384-ejk9wjr1 135 2 a a DT cord-026384-ejk9wjr1 135 3 French french JJ cord-026384-ejk9wjr1 135 4 national national JJ cord-026384-ejk9wjr1 135 5 survey survey NN cord-026384-ejk9wjr1 135 6 , , , cord-026384-ejk9wjr1 135 7 the the DT cord-026384-ejk9wjr1 135 8 majority majority NN cord-026384-ejk9wjr1 135 9 of of IN cord-026384-ejk9wjr1 135 10 neonatologists neonatologist NNS cord-026384-ejk9wjr1 135 11 , , , cord-026384-ejk9wjr1 135 12 obstetricians obstetrician NNS cord-026384-ejk9wjr1 135 13 , , , cord-026384-ejk9wjr1 135 14 and and CC cord-026384-ejk9wjr1 135 15 pediatric pediatric JJ cord-026384-ejk9wjr1 135 16 neurologists neurologist NNS cord-026384-ejk9wjr1 135 17 stated state VBD cord-026384-ejk9wjr1 135 18 that that IN cord-026384-ejk9wjr1 135 19 predicting predict VBG cord-026384-ejk9wjr1 135 20 HRQL HRQL NNP cord-026384-ejk9wjr1 135 21 in in IN cord-026384-ejk9wjr1 135 22 the the DT cord-026384-ejk9wjr1 135 23 long long JJ cord-026384-ejk9wjr1 135 24 term term NN cord-026384-ejk9wjr1 135 25 for for IN cord-026384-ejk9wjr1 135 26 preterm preterm JJ cord-026384-ejk9wjr1 135 27 infants infant NNS cord-026384-ejk9wjr1 135 28 would would MD cord-026384-ejk9wjr1 135 29 be be VB cord-026384-ejk9wjr1 135 30 beneficial beneficial JJ cord-026384-ejk9wjr1 135 31 for for IN cord-026384-ejk9wjr1 135 32 consulting consult VBG cord-026384-ejk9wjr1 135 33 parents parent NNS cord-026384-ejk9wjr1 135 34 about about IN cord-026384-ejk9wjr1 135 35 what what WP cord-026384-ejk9wjr1 135 36 additional additional JJ cord-026384-ejk9wjr1 135 37 responsibilities responsibility NNS cord-026384-ejk9wjr1 135 38 they -PRON- PRP cord-026384-ejk9wjr1 135 39 can can MD cord-026384-ejk9wjr1 135 40 anticipate anticipate VB cord-026384-ejk9wjr1 135 41 in in IN cord-026384-ejk9wjr1 135 42 caring care VBG cord-026384-ejk9wjr1 135 43 for for IN cord-026384-ejk9wjr1 135 44 their -PRON- PRP$ cord-026384-ejk9wjr1 135 45 child child NN cord-026384-ejk9wjr1 135 46 . . . cord-026384-ejk9wjr1 136 1 69 69 CD cord-026384-ejk9wjr1 137 1 The the DT cord-026384-ejk9wjr1 137 2 trajectory trajectory NN cord-026384-ejk9wjr1 137 3 of of IN cord-026384-ejk9wjr1 137 4 HRQL HRQL NNP cord-026384-ejk9wjr1 137 5 from from IN cord-026384-ejk9wjr1 137 6 childhood childhood NN cord-026384-ejk9wjr1 137 7 to to IN cord-026384-ejk9wjr1 137 8 young young JJ cord-026384-ejk9wjr1 137 9 - - HYPH cord-026384-ejk9wjr1 137 10 adulthood adulthood NN cord-026384-ejk9wjr1 137 11 appears appear VBZ cord-026384-ejk9wjr1 137 12 to to TO cord-026384-ejk9wjr1 137 13 improve improve VB cord-026384-ejk9wjr1 137 14 in in IN cord-026384-ejk9wjr1 137 15 both both CC cord-026384-ejk9wjr1 137 16 VLBW VLBW NNP cord-026384-ejk9wjr1 137 17 and and CC cord-026384-ejk9wjr1 137 18 extremely extremely RB cord-026384-ejk9wjr1 137 19 low low JJ cord-026384-ejk9wjr1 137 20 gestational gestational JJ cord-026384-ejk9wjr1 137 21 age age NN cord-026384-ejk9wjr1 137 22 populations population NNS cord-026384-ejk9wjr1 137 23 . . . cord-026384-ejk9wjr1 138 1 70 70 CD cord-026384-ejk9wjr1 138 2 Prediction prediction NN cord-026384-ejk9wjr1 138 3 modeling modeling NN cord-026384-ejk9wjr1 138 4 might may MD cord-026384-ejk9wjr1 138 5 aid aid VB cord-026384-ejk9wjr1 138 6 in in IN cord-026384-ejk9wjr1 138 7 determining determine VBG cord-026384-ejk9wjr1 138 8 which which WDT cord-026384-ejk9wjr1 138 9 factors factor NNS cord-026384-ejk9wjr1 138 10 could could MD cord-026384-ejk9wjr1 138 11 positively positively RB cord-026384-ejk9wjr1 138 12 or or CC cord-026384-ejk9wjr1 138 13 negatively negatively RB cord-026384-ejk9wjr1 138 14 impact impact VB cord-026384-ejk9wjr1 138 15 HRQL HRQL NNS cord-026384-ejk9wjr1 138 16 in in IN cord-026384-ejk9wjr1 138 17 this this DT cord-026384-ejk9wjr1 138 18 vulnerable vulnerable JJ cord-026384-ejk9wjr1 138 19 population population NN cord-026384-ejk9wjr1 138 20 . . . cord-026384-ejk9wjr1 139 1 Finally finally RB cord-026384-ejk9wjr1 139 2 , , , cord-026384-ejk9wjr1 139 3 we -PRON- PRP cord-026384-ejk9wjr1 139 4 must must MD cord-026384-ejk9wjr1 139 5 consider consider VB cord-026384-ejk9wjr1 139 6 the the DT cord-026384-ejk9wjr1 139 7 age age NN cord-026384-ejk9wjr1 139 8 at at IN cord-026384-ejk9wjr1 139 9 which which WDT cord-026384-ejk9wjr1 139 10 outcomes outcome NNS cord-026384-ejk9wjr1 139 11 are be VBP cord-026384-ejk9wjr1 139 12 being be VBG cord-026384-ejk9wjr1 139 13 predicted predict VBN cord-026384-ejk9wjr1 139 14 . . . cord-026384-ejk9wjr1 140 1 It -PRON- PRP cord-026384-ejk9wjr1 140 2 is be VBZ cord-026384-ejk9wjr1 140 3 evident evident JJ cord-026384-ejk9wjr1 140 4 that that IN cord-026384-ejk9wjr1 140 5 lower low JJR cord-026384-ejk9wjr1 140 6 gestational gestational JJ cord-026384-ejk9wjr1 140 7 age age NN cord-026384-ejk9wjr1 140 8 is be VBZ cord-026384-ejk9wjr1 140 9 inversely inversely RB cord-026384-ejk9wjr1 140 10 proportional proportional JJ cord-026384-ejk9wjr1 140 11 to to IN cord-026384-ejk9wjr1 140 12 rates rate NNS cord-026384-ejk9wjr1 140 13 of of IN cord-026384-ejk9wjr1 140 14 NDI NDI NNP cord-026384-ejk9wjr1 140 15 and and CC cord-026384-ejk9wjr1 140 16 academic academic JJ cord-026384-ejk9wjr1 140 17 achievement achievement NN cord-026384-ejk9wjr1 140 18 in in IN cord-026384-ejk9wjr1 140 19 adolescence adolescence NN cord-026384-ejk9wjr1 140 20 . . . cord-026384-ejk9wjr1 141 1 71 71 CD cord-026384-ejk9wjr1 141 2 , , , cord-026384-ejk9wjr1 141 3 72 72 CD cord-026384-ejk9wjr1 142 1 However however RB cord-026384-ejk9wjr1 142 2 , , , cord-026384-ejk9wjr1 142 3 the the DT cord-026384-ejk9wjr1 142 4 vast vast JJ cord-026384-ejk9wjr1 142 5 majority majority NN cord-026384-ejk9wjr1 142 6 of of IN cord-026384-ejk9wjr1 142 7 risk risk NN cord-026384-ejk9wjr1 142 8 prediction prediction NN cord-026384-ejk9wjr1 142 9 models model NNS cord-026384-ejk9wjr1 142 10 assessed assess VBD cord-026384-ejk9wjr1 142 11 outcomes outcome NNS cord-026384-ejk9wjr1 142 12 at at IN cord-026384-ejk9wjr1 142 13 the the DT cord-026384-ejk9wjr1 142 14 age age NN cord-026384-ejk9wjr1 142 15 of of IN cord-026384-ejk9wjr1 142 16 3 3 CD cord-026384-ejk9wjr1 142 17 years year NNS cord-026384-ejk9wjr1 142 18 or or CC cord-026384-ejk9wjr1 142 19 less less JJR cord-026384-ejk9wjr1 142 20 , , , cord-026384-ejk9wjr1 142 21 with with IN cord-026384-ejk9wjr1 142 22 only only RB cord-026384-ejk9wjr1 142 23 three three CD cord-026384-ejk9wjr1 142 24 studies study NNS cord-026384-ejk9wjr1 142 25 doing do VBG cord-026384-ejk9wjr1 142 26 so so RB cord-026384-ejk9wjr1 142 27 at at IN cord-026384-ejk9wjr1 142 28 10 10 CD cord-026384-ejk9wjr1 142 29 years year NNS cord-026384-ejk9wjr1 142 30 of of IN cord-026384-ejk9wjr1 142 31 age age NN cord-026384-ejk9wjr1 142 32 or or CC cord-026384-ejk9wjr1 142 33 above above RB cord-026384-ejk9wjr1 142 34 . . . cord-026384-ejk9wjr1 143 1 Although although IN cord-026384-ejk9wjr1 143 2 early early JJ cord-026384-ejk9wjr1 143 3 childhood childhood NN cord-026384-ejk9wjr1 143 4 outcomes outcome NNS cord-026384-ejk9wjr1 143 5 may may MD cord-026384-ejk9wjr1 143 6 give give VB cord-026384-ejk9wjr1 143 7 clues clue NNS cord-026384-ejk9wjr1 143 8 about about IN cord-026384-ejk9wjr1 143 9 later later JJ cord-026384-ejk9wjr1 143 10 development development NN cord-026384-ejk9wjr1 143 11 , , , cord-026384-ejk9wjr1 143 12 many many JJ cord-026384-ejk9wjr1 143 13 problems problem NNS cord-026384-ejk9wjr1 143 14 do do VBP cord-026384-ejk9wjr1 143 15 not not RB cord-026384-ejk9wjr1 143 16 manifest manifest VB cord-026384-ejk9wjr1 143 17 until until IN cord-026384-ejk9wjr1 143 18 later later RB cord-026384-ejk9wjr1 143 19 in in IN cord-026384-ejk9wjr1 143 20 childhood childhood NN cord-026384-ejk9wjr1 143 21 , , , cord-026384-ejk9wjr1 143 22 such such JJ cord-026384-ejk9wjr1 143 23 as as IN cord-026384-ejk9wjr1 143 24 learning learn VBG cord-026384-ejk9wjr1 143 25 disabilities disability NNS cord-026384-ejk9wjr1 143 26 and and CC cord-026384-ejk9wjr1 143 27 certain certain JJ cord-026384-ejk9wjr1 143 28 psychiatric psychiatric JJ cord-026384-ejk9wjr1 143 29 disorders disorder NNS cord-026384-ejk9wjr1 143 30 . . . cord-026384-ejk9wjr1 144 1 Developmental developmental JJ cord-026384-ejk9wjr1 144 2 disability disability NN cord-026384-ejk9wjr1 144 3 severity severity NN cord-026384-ejk9wjr1 144 4 can can MD cord-026384-ejk9wjr1 144 5 fluctuate fluctuate VB cord-026384-ejk9wjr1 144 6 throughout throughout IN cord-026384-ejk9wjr1 144 7 childhood childhood NN cord-026384-ejk9wjr1 144 8 , , , cord-026384-ejk9wjr1 144 9 with with IN cord-026384-ejk9wjr1 144 10 catch catch NN cord-026384-ejk9wjr1 144 11 - - HYPH cord-026384-ejk9wjr1 144 12 up up NN cord-026384-ejk9wjr1 144 13 occurring occur VBG cord-026384-ejk9wjr1 144 14 in in IN cord-026384-ejk9wjr1 144 15 early early JJ cord-026384-ejk9wjr1 144 16 preterm preterm JJR cord-026384-ejk9wjr1 144 17 children child NNS cord-026384-ejk9wjr1 144 18 and and CC cord-026384-ejk9wjr1 144 19 worsening worsen VBG cord-026384-ejk9wjr1 144 20 delay delay NN cord-026384-ejk9wjr1 144 21 in in IN cord-026384-ejk9wjr1 144 22 some some DT cord-026384-ejk9wjr1 144 23 moderate moderate JJ cord-026384-ejk9wjr1 144 24 and and CC cord-026384-ejk9wjr1 144 25 late late JJ cord-026384-ejk9wjr1 144 26 preterm preterm JJ cord-026384-ejk9wjr1 144 27 children child NNS cord-026384-ejk9wjr1 144 28 . . . cord-026384-ejk9wjr1 145 1 73 73 CD cord-026384-ejk9wjr1 145 2 , , , cord-026384-ejk9wjr1 145 3 74 74 CD cord-026384-ejk9wjr1 146 1 Although although IN cord-026384-ejk9wjr1 146 2 cohorts cohort NNS cord-026384-ejk9wjr1 146 3 of of IN cord-026384-ejk9wjr1 146 4 preterm preterm JJ cord-026384-ejk9wjr1 146 5 infants infant NNS cord-026384-ejk9wjr1 146 6 are be VBP cord-026384-ejk9wjr1 146 7 not not RB cord-026384-ejk9wjr1 146 8 usually usually RB cord-026384-ejk9wjr1 146 9 followed follow VBN cord-026384-ejk9wjr1 146 10 for for IN cord-026384-ejk9wjr1 146 11 more more JJR cord-026384-ejk9wjr1 146 12 than than IN cord-026384-ejk9wjr1 146 13 several several JJ cord-026384-ejk9wjr1 146 14 years year NNS cord-026384-ejk9wjr1 146 15 , , , cord-026384-ejk9wjr1 146 16 likely likely RB cord-026384-ejk9wjr1 146 17 due due IN cord-026384-ejk9wjr1 146 18 to to IN cord-026384-ejk9wjr1 146 19 lack lack NN cord-026384-ejk9wjr1 146 20 of of IN cord-026384-ejk9wjr1 146 21 resources resource NNS cord-026384-ejk9wjr1 146 22 and and CC cord-026384-ejk9wjr1 146 23 expense expense NN cord-026384-ejk9wjr1 146 24 , , , cord-026384-ejk9wjr1 146 25 recent recent JJ cord-026384-ejk9wjr1 146 26 studies study NNS cord-026384-ejk9wjr1 146 27 have have VBP cord-026384-ejk9wjr1 146 28 used use VBN cord-026384-ejk9wjr1 146 29 data datum NNS cord-026384-ejk9wjr1 146 30 from from IN cord-026384-ejk9wjr1 146 31 national national JJ cord-026384-ejk9wjr1 146 32 registries registry NNS cord-026384-ejk9wjr1 146 33 to to TO cord-026384-ejk9wjr1 146 34 link link VB cord-026384-ejk9wjr1 146 35 neonatal neonatal JJ cord-026384-ejk9wjr1 146 36 clinical clinical JJ cord-026384-ejk9wjr1 146 37 data datum NNS cord-026384-ejk9wjr1 146 38 to to IN cord-026384-ejk9wjr1 146 39 sampled sample VBN cord-026384-ejk9wjr1 146 40 adults adult NNS cord-026384-ejk9wjr1 146 41 , , , cord-026384-ejk9wjr1 146 42 providing provide VBG cord-026384-ejk9wjr1 146 43 evidence evidence NN cord-026384-ejk9wjr1 146 44 of of IN cord-026384-ejk9wjr1 146 45 increased increase VBN cord-026384-ejk9wjr1 146 46 rates rate NNS cord-026384-ejk9wjr1 146 47 of of IN cord-026384-ejk9wjr1 146 48 adverse adverse JJ cord-026384-ejk9wjr1 146 49 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 146 50 , , , cord-026384-ejk9wjr1 146 51 behavioral behavioral JJ cord-026384-ejk9wjr1 146 52 , , , cord-026384-ejk9wjr1 146 53 and and CC cord-026384-ejk9wjr1 146 54 educational educational JJ cord-026384-ejk9wjr1 146 55 outcomes outcome NNS cord-026384-ejk9wjr1 146 56 among among IN cord-026384-ejk9wjr1 146 57 adults adult NNS cord-026384-ejk9wjr1 146 58 born bear VBD cord-026384-ejk9wjr1 146 59 preterm preterm NNS cord-026384-ejk9wjr1 146 60 . . . cord-026384-ejk9wjr1 147 1 75 75 CD cord-026384-ejk9wjr1 147 2 , , , cord-026384-ejk9wjr1 147 3 76 76 CD cord-026384-ejk9wjr1 147 4 Opportunities opportunity NNS cord-026384-ejk9wjr1 147 5 are be VBP cord-026384-ejk9wjr1 147 6 therefore therefore RB cord-026384-ejk9wjr1 147 7 available available JJ cord-026384-ejk9wjr1 147 8 to to TO cord-026384-ejk9wjr1 147 9 use use VB cord-026384-ejk9wjr1 147 10 long long JJ cord-026384-ejk9wjr1 147 11 - - HYPH cord-026384-ejk9wjr1 147 12 term term NN cord-026384-ejk9wjr1 147 13 data datum NNS cord-026384-ejk9wjr1 147 14 to to TO cord-026384-ejk9wjr1 147 15 extend extend VB cord-026384-ejk9wjr1 147 16 risk risk NN cord-026384-ejk9wjr1 147 17 prediction prediction NN cord-026384-ejk9wjr1 147 18 models model NNS cord-026384-ejk9wjr1 147 19 beyond beyond IN cord-026384-ejk9wjr1 147 20 the the DT cord-026384-ejk9wjr1 147 21 first first JJ cord-026384-ejk9wjr1 147 22 few few JJ cord-026384-ejk9wjr1 147 23 years year NNS cord-026384-ejk9wjr1 147 24 of of IN cord-026384-ejk9wjr1 147 25 life life NN cord-026384-ejk9wjr1 147 26 . . . cord-026384-ejk9wjr1 148 1 Variable variable JJ cord-026384-ejk9wjr1 148 2 selection selection NN cord-026384-ejk9wjr1 148 3 . . . cord-026384-ejk9wjr1 149 1 Most Most JJS cord-026384-ejk9wjr1 149 2 of of IN cord-026384-ejk9wjr1 149 3 the the DT cord-026384-ejk9wjr1 149 4 risk risk NN cord-026384-ejk9wjr1 149 5 models model NNS cord-026384-ejk9wjr1 149 6 reviewed review VBN cord-026384-ejk9wjr1 149 7 relied rely VBD cord-026384-ejk9wjr1 149 8 primarily primarily RB cord-026384-ejk9wjr1 149 9 on on IN cord-026384-ejk9wjr1 149 10 physiologic physiologic JJ cord-026384-ejk9wjr1 149 11 and and CC cord-026384-ejk9wjr1 149 12 clinical clinical JJ cord-026384-ejk9wjr1 149 13 measures measure NNS cord-026384-ejk9wjr1 149 14 obtained obtain VBN cord-026384-ejk9wjr1 149 15 during during IN cord-026384-ejk9wjr1 149 16 the the DT cord-026384-ejk9wjr1 149 17 NICU NICU NNP cord-026384-ejk9wjr1 149 18 stay stay NN cord-026384-ejk9wjr1 149 19 . . . cord-026384-ejk9wjr1 150 1 While while IN cord-026384-ejk9wjr1 150 2 an an DT cord-026384-ejk9wjr1 150 3 emphasis emphasis NN cord-026384-ejk9wjr1 150 4 on on IN cord-026384-ejk9wjr1 150 5 biologic biologic JJ cord-026384-ejk9wjr1 150 6 risk risk NN cord-026384-ejk9wjr1 150 7 factors factor NNS cord-026384-ejk9wjr1 150 8 is be VBZ cord-026384-ejk9wjr1 150 9 clearly clearly RB cord-026384-ejk9wjr1 150 10 reasonable reasonable JJ cord-026384-ejk9wjr1 150 11 given give VBN cord-026384-ejk9wjr1 150 12 the the DT cord-026384-ejk9wjr1 150 13 known know VBN cord-026384-ejk9wjr1 150 14 associations association NNS cord-026384-ejk9wjr1 150 15 between between IN cord-026384-ejk9wjr1 150 16 perinatal perinatal JJ cord-026384-ejk9wjr1 150 17 morbidities morbidity NNS cord-026384-ejk9wjr1 150 18 and and CC cord-026384-ejk9wjr1 150 19 long long JJ cord-026384-ejk9wjr1 150 20 - - HYPH cord-026384-ejk9wjr1 150 21 term term NN cord-026384-ejk9wjr1 150 22 outcomes outcome NNS cord-026384-ejk9wjr1 150 23 , , , cord-026384-ejk9wjr1 150 24 there there EX cord-026384-ejk9wjr1 150 25 is be VBZ cord-026384-ejk9wjr1 150 26 strong strong JJ cord-026384-ejk9wjr1 150 27 evidence evidence NN cord-026384-ejk9wjr1 150 28 in in IN cord-026384-ejk9wjr1 150 29 the the DT cord-026384-ejk9wjr1 150 30 literature literature NN cord-026384-ejk9wjr1 150 31 suggesting suggest VBG cord-026384-ejk9wjr1 150 32 associations association NNS cord-026384-ejk9wjr1 150 33 between between IN cord-026384-ejk9wjr1 150 34 sociodemographic sociodemographic JJ cord-026384-ejk9wjr1 150 35 factors factor NNS cord-026384-ejk9wjr1 150 36 like like IN cord-026384-ejk9wjr1 150 37 parental parental JJ cord-026384-ejk9wjr1 150 38 race race NN cord-026384-ejk9wjr1 150 39 , , , cord-026384-ejk9wjr1 150 40 education education NN cord-026384-ejk9wjr1 150 41 , , , cord-026384-ejk9wjr1 150 42 and and CC cord-026384-ejk9wjr1 150 43 age age NN cord-026384-ejk9wjr1 150 44 , , , cord-026384-ejk9wjr1 150 45 and and CC cord-026384-ejk9wjr1 150 46 outcomes outcome NNS cord-026384-ejk9wjr1 150 47 such such JJ cord-026384-ejk9wjr1 150 48 as as IN cord-026384-ejk9wjr1 150 49 cognitive cognitive JJ cord-026384-ejk9wjr1 150 50 impairment impairment NN cord-026384-ejk9wjr1 150 51 , , , cord-026384-ejk9wjr1 150 52 cerebral cerebral JJ cord-026384-ejk9wjr1 150 53 palsy palsy NN cord-026384-ejk9wjr1 150 54 , , , cord-026384-ejk9wjr1 150 55 and and CC cord-026384-ejk9wjr1 150 56 mental mental JJ cord-026384-ejk9wjr1 150 57 health health NN cord-026384-ejk9wjr1 150 58 disorders disorder NNS cord-026384-ejk9wjr1 150 59 in in IN cord-026384-ejk9wjr1 150 60 children child NNS cord-026384-ejk9wjr1 150 61 born bear VBD cord-026384-ejk9wjr1 150 62 preterm preterm NNS cord-026384-ejk9wjr1 150 63 . . . cord-026384-ejk9wjr1 151 1 More more RBR cord-026384-ejk9wjr1 151 2 specific specific JJ cord-026384-ejk9wjr1 151 3 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 151 4 variables variable NNS cord-026384-ejk9wjr1 151 5 such such JJ cord-026384-ejk9wjr1 151 6 as as IN cord-026384-ejk9wjr1 151 7 lower low JJR cord-026384-ejk9wjr1 151 8 parental parental JJ cord-026384-ejk9wjr1 151 9 education education NN cord-026384-ejk9wjr1 151 10 , , , cord-026384-ejk9wjr1 151 11 maternal maternal JJ cord-026384-ejk9wjr1 151 12 income income NN cord-026384-ejk9wjr1 151 13 , , , cord-026384-ejk9wjr1 151 14 insurance insurance NN cord-026384-ejk9wjr1 151 15 status status NN cord-026384-ejk9wjr1 151 16 , , , cord-026384-ejk9wjr1 151 17 foreign foreign JJ cord-026384-ejk9wjr1 151 18 country country NN cord-026384-ejk9wjr1 151 19 of of IN cord-026384-ejk9wjr1 151 20 birth birth NN cord-026384-ejk9wjr1 151 21 by by IN cord-026384-ejk9wjr1 151 22 a a DT cord-026384-ejk9wjr1 151 23 parent parent NN cord-026384-ejk9wjr1 151 24 , , , cord-026384-ejk9wjr1 151 25 and and CC cord-026384-ejk9wjr1 151 26 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 151 27 status status NN cord-026384-ejk9wjr1 151 28 as as IN cord-026384-ejk9wjr1 151 29 defined define VBN cord-026384-ejk9wjr1 151 30 by by IN cord-026384-ejk9wjr1 151 31 the the DT cord-026384-ejk9wjr1 151 32 Elly Elly NNP cord-026384-ejk9wjr1 151 33 - - HYPH cord-026384-ejk9wjr1 151 34 Irving Irving NNP cord-026384-ejk9wjr1 151 35 Socioeconomic Socioeconomic NNP cord-026384-ejk9wjr1 151 36 Index Index NNP cord-026384-ejk9wjr1 151 37 have have VBP cord-026384-ejk9wjr1 151 38 been be VBN cord-026384-ejk9wjr1 151 39 repeatedly repeatedly RB cord-026384-ejk9wjr1 151 40 correlated correlate VBN cord-026384-ejk9wjr1 151 41 with with IN cord-026384-ejk9wjr1 151 42 reduced reduce VBN cord-026384-ejk9wjr1 151 43 mental mental JJ cord-026384-ejk9wjr1 151 44 development development NN cord-026384-ejk9wjr1 151 45 index index NN cord-026384-ejk9wjr1 151 46 , , , cord-026384-ejk9wjr1 151 47 psychomotor psychomotor NNP cord-026384-ejk9wjr1 151 48 development development NN cord-026384-ejk9wjr1 151 49 index index NN cord-026384-ejk9wjr1 151 50 , , , cord-026384-ejk9wjr1 151 51 intelligence intelligence NN cord-026384-ejk9wjr1 151 52 quotient quotient NN cord-026384-ejk9wjr1 151 53 , , , cord-026384-ejk9wjr1 151 54 and and CC cord-026384-ejk9wjr1 151 55 social social JJ cord-026384-ejk9wjr1 151 56 competence competence NN cord-026384-ejk9wjr1 151 57 throughout throughout IN cord-026384-ejk9wjr1 151 58 childhood childhood NN cord-026384-ejk9wjr1 151 59 . . . cord-026384-ejk9wjr1 152 1 71 71 CD cord-026384-ejk9wjr1 152 2 , , , cord-026384-ejk9wjr1 152 3 72 72 CD cord-026384-ejk9wjr1 152 4 , , , cord-026384-ejk9wjr1 152 5 [ [ -LRB- cord-026384-ejk9wjr1 152 6 77 77 CD cord-026384-ejk9wjr1 152 7 ] ] -RRB- cord-026384-ejk9wjr1 153 1 [ [ -LRB- cord-026384-ejk9wjr1 153 2 78 78 CD cord-026384-ejk9wjr1 153 3 ] ] -RRB- cord-026384-ejk9wjr1 153 4 [ [ -LRB- cord-026384-ejk9wjr1 153 5 79 79 CD cord-026384-ejk9wjr1 153 6 ] ] -RRB- cord-026384-ejk9wjr1 154 1 [ [ -LRB- cord-026384-ejk9wjr1 154 2 80 80 CD cord-026384-ejk9wjr1 154 3 ] ] -RRB- cord-026384-ejk9wjr1 155 1 [ [ -LRB- cord-026384-ejk9wjr1 155 2 81 81 CD cord-026384-ejk9wjr1 155 3 ] ] -RRB- cord-026384-ejk9wjr1 156 1 [ [ -LRB- cord-026384-ejk9wjr1 156 2 82 82 CD cord-026384-ejk9wjr1 156 3 ] ] -RRB- cord-026384-ejk9wjr1 157 1 The the DT cord-026384-ejk9wjr1 157 2 geographic geographic JJ cord-026384-ejk9wjr1 157 3 area area NN cord-026384-ejk9wjr1 157 4 in in IN cord-026384-ejk9wjr1 157 5 which which WDT cord-026384-ejk9wjr1 157 6 preterm preterm JJ cord-026384-ejk9wjr1 157 7 neonates neonate NNS cord-026384-ejk9wjr1 157 8 are be VBP cord-026384-ejk9wjr1 157 9 raised raise VBN cord-026384-ejk9wjr1 157 10 could could MD cord-026384-ejk9wjr1 157 11 also also RB cord-026384-ejk9wjr1 157 12 have have VB cord-026384-ejk9wjr1 157 13 a a DT cord-026384-ejk9wjr1 157 14 profound profound JJ cord-026384-ejk9wjr1 157 15 influence influence NN cord-026384-ejk9wjr1 157 16 on on IN cord-026384-ejk9wjr1 157 17 their -PRON- PRP$ cord-026384-ejk9wjr1 157 18 development development NN cord-026384-ejk9wjr1 157 19 . . . cord-026384-ejk9wjr1 158 1 Neighborhood neighborhood NN cord-026384-ejk9wjr1 158 2 poverty poverty NN cord-026384-ejk9wjr1 158 3 rate rate NN cord-026384-ejk9wjr1 158 4 , , , cord-026384-ejk9wjr1 158 5 high high JJ cord-026384-ejk9wjr1 158 6 school school NN cord-026384-ejk9wjr1 158 7 dropout dropout NN cord-026384-ejk9wjr1 158 8 rate rate NN cord-026384-ejk9wjr1 158 9 , , , cord-026384-ejk9wjr1 158 10 and and CC cord-026384-ejk9wjr1 158 11 place place NN cord-026384-ejk9wjr1 158 12 of of IN cord-026384-ejk9wjr1 158 13 residence residence NN cord-026384-ejk9wjr1 159 1 ( ( -LRB- cord-026384-ejk9wjr1 159 2 metropolitan metropolitan JJ cord-026384-ejk9wjr1 159 3 vs. vs. FW cord-026384-ejk9wjr1 159 4 non non JJ cord-026384-ejk9wjr1 159 5 - - JJ cord-026384-ejk9wjr1 159 6 metropolitan metropolitan JJ cord-026384-ejk9wjr1 159 7 ) ) -RRB- cord-026384-ejk9wjr1 159 8 have have VBP cord-026384-ejk9wjr1 159 9 all all DT cord-026384-ejk9wjr1 159 10 been be VBN cord-026384-ejk9wjr1 159 11 correlated correlate VBN cord-026384-ejk9wjr1 159 12 with with IN cord-026384-ejk9wjr1 159 13 academic academic JJ cord-026384-ejk9wjr1 159 14 skills skill NNS cord-026384-ejk9wjr1 159 15 and and CC cord-026384-ejk9wjr1 159 16 rate rate NN cord-026384-ejk9wjr1 159 17 of of IN cord-026384-ejk9wjr1 159 18 mental mental JJ cord-026384-ejk9wjr1 159 19 health health NN cord-026384-ejk9wjr1 159 20 disorders disorder NNS cord-026384-ejk9wjr1 159 21 among among IN cord-026384-ejk9wjr1 159 22 low low JJ cord-026384-ejk9wjr1 159 23 birth birth NN cord-026384-ejk9wjr1 159 24 weight weight NN cord-026384-ejk9wjr1 159 25 children child NNS cord-026384-ejk9wjr1 159 26 . . . cord-026384-ejk9wjr1 160 1 83 83 CD cord-026384-ejk9wjr1 161 1 , , , cord-026384-ejk9wjr1 161 2 84 84 CD cord-026384-ejk9wjr1 161 3 Only only RB cord-026384-ejk9wjr1 161 4 12 12 CD cord-026384-ejk9wjr1 161 5 of of IN cord-026384-ejk9wjr1 161 6 the the DT cord-026384-ejk9wjr1 161 7 43 43 CD cord-026384-ejk9wjr1 161 8 models model NNS cord-026384-ejk9wjr1 161 9 reviewed review VBN cord-026384-ejk9wjr1 161 10 included include VBD cord-026384-ejk9wjr1 161 11 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 161 12 variables variable NNS cord-026384-ejk9wjr1 161 13 . . . cord-026384-ejk9wjr1 162 1 This this DT cord-026384-ejk9wjr1 162 2 may may MD cord-026384-ejk9wjr1 162 3 be be VB cord-026384-ejk9wjr1 162 4 due due JJ cord-026384-ejk9wjr1 162 5 , , , cord-026384-ejk9wjr1 162 6 at at IN cord-026384-ejk9wjr1 162 7 least least JJS cord-026384-ejk9wjr1 162 8 in in IN cord-026384-ejk9wjr1 162 9 part part NN cord-026384-ejk9wjr1 162 10 , , , cord-026384-ejk9wjr1 162 11 to to IN cord-026384-ejk9wjr1 162 12 the the DT cord-026384-ejk9wjr1 162 13 difficulty difficulty NN cord-026384-ejk9wjr1 162 14 in in IN cord-026384-ejk9wjr1 162 15 obtaining obtain VBG cord-026384-ejk9wjr1 162 16 social social JJ cord-026384-ejk9wjr1 162 17 , , , cord-026384-ejk9wjr1 162 18 economic economic JJ cord-026384-ejk9wjr1 162 19 , , , cord-026384-ejk9wjr1 162 20 and and CC cord-026384-ejk9wjr1 162 21 demographic demographic JJ cord-026384-ejk9wjr1 162 22 data datum NNS cord-026384-ejk9wjr1 162 23 ; ; : cord-026384-ejk9wjr1 162 24 these these DT cord-026384-ejk9wjr1 162 25 variables variable NNS cord-026384-ejk9wjr1 162 26 are be VBP cord-026384-ejk9wjr1 162 27 often often RB cord-026384-ejk9wjr1 162 28 not not RB cord-026384-ejk9wjr1 162 29 collected collect VBN cord-026384-ejk9wjr1 162 30 upon upon IN cord-026384-ejk9wjr1 162 31 hospital hospital NN cord-026384-ejk9wjr1 162 32 admission admission NN cord-026384-ejk9wjr1 162 33 . . . cord-026384-ejk9wjr1 163 1 Additionally additionally RB cord-026384-ejk9wjr1 163 2 , , , cord-026384-ejk9wjr1 163 3 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 163 4 information information NN cord-026384-ejk9wjr1 163 5 is be VBZ cord-026384-ejk9wjr1 163 6 often often RB cord-026384-ejk9wjr1 163 7 poorly poorly RB cord-026384-ejk9wjr1 163 8 , , , cord-026384-ejk9wjr1 163 9 inaccurately inaccurately RB cord-026384-ejk9wjr1 163 10 , , , cord-026384-ejk9wjr1 163 11 and and CC cord-026384-ejk9wjr1 163 12 variably variably RB cord-026384-ejk9wjr1 163 13 recorded record VBN cord-026384-ejk9wjr1 163 14 or or CC cord-026384-ejk9wjr1 163 15 is be VBZ cord-026384-ejk9wjr1 163 16 largely largely RB cord-026384-ejk9wjr1 163 17 missing missing JJ cord-026384-ejk9wjr1 163 18 . . . cord-026384-ejk9wjr1 164 1 85 85 CD cord-026384-ejk9wjr1 165 1 Some some DT cord-026384-ejk9wjr1 165 2 risk risk NN cord-026384-ejk9wjr1 165 3 prediction prediction NN cord-026384-ejk9wjr1 165 4 models model NNS cord-026384-ejk9wjr1 165 5 collected collect VBD cord-026384-ejk9wjr1 165 6 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 165 7 variables variable NNS cord-026384-ejk9wjr1 165 8 at at IN cord-026384-ejk9wjr1 165 9 the the DT cord-026384-ejk9wjr1 165 10 follow follow NN cord-026384-ejk9wjr1 165 11 - - HYPH cord-026384-ejk9wjr1 165 12 up up NN cord-026384-ejk9wjr1 165 13 visit visit NN cord-026384-ejk9wjr1 165 14 when when WRB cord-026384-ejk9wjr1 165 15 outcomes outcome NNS cord-026384-ejk9wjr1 165 16 were be VBD cord-026384-ejk9wjr1 165 17 assessed assess VBN cord-026384-ejk9wjr1 165 18 . . . cord-026384-ejk9wjr1 166 1 This this DT cord-026384-ejk9wjr1 166 2 is be VBZ cord-026384-ejk9wjr1 166 3 an an DT cord-026384-ejk9wjr1 166 4 imperfect imperfect JJ cord-026384-ejk9wjr1 166 5 method method NN cord-026384-ejk9wjr1 166 6 given give VBN cord-026384-ejk9wjr1 166 7 that that IN cord-026384-ejk9wjr1 166 8 factors factor NNS cord-026384-ejk9wjr1 166 9 such such JJ cord-026384-ejk9wjr1 166 10 as as IN cord-026384-ejk9wjr1 166 11 household household NN cord-026384-ejk9wjr1 166 12 setting setting NN cord-026384-ejk9wjr1 166 13 and and CC cord-026384-ejk9wjr1 166 14 family family NN cord-026384-ejk9wjr1 166 15 income income NN cord-026384-ejk9wjr1 166 16 may may MD cord-026384-ejk9wjr1 166 17 change change VB cord-026384-ejk9wjr1 166 18 substantially substantially RB cord-026384-ejk9wjr1 166 19 in in IN cord-026384-ejk9wjr1 166 20 the the DT cord-026384-ejk9wjr1 166 21 years year NNS cord-026384-ejk9wjr1 166 22 following follow VBG cord-026384-ejk9wjr1 166 23 NICU NICU NNP cord-026384-ejk9wjr1 166 24 discharge discharge NN cord-026384-ejk9wjr1 166 25 and and CC cord-026384-ejk9wjr1 166 26 affect affect VBP cord-026384-ejk9wjr1 166 27 children child NNS cord-026384-ejk9wjr1 166 28 's 's POS cord-026384-ejk9wjr1 166 29 health health NN cord-026384-ejk9wjr1 166 30 . . . cord-026384-ejk9wjr1 167 1 86 86 CD cord-026384-ejk9wjr1 167 2 , , , cord-026384-ejk9wjr1 167 3 87 87 CD cord-026384-ejk9wjr1 168 1 In in IN cord-026384-ejk9wjr1 168 2 some some DT cord-026384-ejk9wjr1 168 3 models model NNS cord-026384-ejk9wjr1 168 4 , , , cord-026384-ejk9wjr1 168 5 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 168 6 variables variable NNS cord-026384-ejk9wjr1 168 7 were be VBD cord-026384-ejk9wjr1 168 8 not not RB cord-026384-ejk9wjr1 168 9 included include VBN cord-026384-ejk9wjr1 168 10 because because IN cord-026384-ejk9wjr1 168 11 they -PRON- PRP cord-026384-ejk9wjr1 168 12 did do VBD cord-026384-ejk9wjr1 168 13 not not RB cord-026384-ejk9wjr1 168 14 significantly significantly RB cord-026384-ejk9wjr1 168 15 improve improve VB cord-026384-ejk9wjr1 168 16 the the DT cord-026384-ejk9wjr1 168 17 model model NN cord-026384-ejk9wjr1 168 18 's 's POS cord-026384-ejk9wjr1 168 19 predictive predictive JJ cord-026384-ejk9wjr1 168 20 ability ability NN cord-026384-ejk9wjr1 168 21 . . . cord-026384-ejk9wjr1 169 1 45 45 CD cord-026384-ejk9wjr1 170 1 Testing test VBG cord-026384-ejk9wjr1 170 2 the the DT cord-026384-ejk9wjr1 170 3 effects effect NNS cord-026384-ejk9wjr1 170 4 of of IN cord-026384-ejk9wjr1 170 5 social social JJ cord-026384-ejk9wjr1 170 6 factors factor NNS cord-026384-ejk9wjr1 170 7 on on IN cord-026384-ejk9wjr1 170 8 infant infant NN cord-026384-ejk9wjr1 170 9 and and CC cord-026384-ejk9wjr1 170 10 child child NN cord-026384-ejk9wjr1 170 11 outcomes outcome NNS cord-026384-ejk9wjr1 170 12 requires require VBZ cord-026384-ejk9wjr1 170 13 samples sample NNS cord-026384-ejk9wjr1 170 14 that that WDT cord-026384-ejk9wjr1 170 15 are be VBP cord-026384-ejk9wjr1 170 16 socially socially RB cord-026384-ejk9wjr1 170 17 and and CC cord-026384-ejk9wjr1 170 18 economically economically RB cord-026384-ejk9wjr1 170 19 diverse diverse JJ cord-026384-ejk9wjr1 170 20 . . . cord-026384-ejk9wjr1 171 1 Even even RB cord-026384-ejk9wjr1 171 2 large large JJ cord-026384-ejk9wjr1 171 3 , , , cord-026384-ejk9wjr1 171 4 diverse diverse JJ cord-026384-ejk9wjr1 171 5 study study NN cord-026384-ejk9wjr1 171 6 populations population NNS cord-026384-ejk9wjr1 171 7 may may MD cord-026384-ejk9wjr1 171 8 become become VB cord-026384-ejk9wjr1 171 9 more more RBR cord-026384-ejk9wjr1 171 10 homogeneous homogeneous JJ cord-026384-ejk9wjr1 171 11 over over IN cord-026384-ejk9wjr1 171 12 time time NN cord-026384-ejk9wjr1 171 13 , , , cord-026384-ejk9wjr1 171 14 as as IN cord-026384-ejk9wjr1 171 15 subjects subject NNS cord-026384-ejk9wjr1 171 16 of of IN cord-026384-ejk9wjr1 171 17 lower low JJR cord-026384-ejk9wjr1 171 18 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 171 19 status status NN cord-026384-ejk9wjr1 171 20 and and CC cord-026384-ejk9wjr1 171 21 non non JJ cord-026384-ejk9wjr1 171 22 - - JJ cord-026384-ejk9wjr1 171 23 white white JJ cord-026384-ejk9wjr1 171 24 race race NN cord-026384-ejk9wjr1 171 25 are be VBP cord-026384-ejk9wjr1 171 26 more more RBR cord-026384-ejk9wjr1 171 27 likely likely JJ cord-026384-ejk9wjr1 171 28 to to TO cord-026384-ejk9wjr1 171 29 drop drop VB cord-026384-ejk9wjr1 171 30 out out IN cord-026384-ejk9wjr1 171 31 of of IN cord-026384-ejk9wjr1 171 32 studies study NNS cord-026384-ejk9wjr1 171 33 dependent dependent JJ cord-026384-ejk9wjr1 171 34 on on IN cord-026384-ejk9wjr1 171 35 long long JJ cord-026384-ejk9wjr1 171 36 - - HYPH cord-026384-ejk9wjr1 171 37 term term NN cord-026384-ejk9wjr1 171 38 follow follow NN cord-026384-ejk9wjr1 171 39 - - HYPH cord-026384-ejk9wjr1 171 40 up up NN cord-026384-ejk9wjr1 171 41 . . . cord-026384-ejk9wjr1 172 1 41 41 CD cord-026384-ejk9wjr1 173 1 And and CC cord-026384-ejk9wjr1 173 2 treating treat VBG cord-026384-ejk9wjr1 173 3 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 173 4 variables variable NNS cord-026384-ejk9wjr1 173 5 as as IN cord-026384-ejk9wjr1 173 6 statistically statistically RB cord-026384-ejk9wjr1 173 7 independent independent JJ cord-026384-ejk9wjr1 173 8 factors factor NNS cord-026384-ejk9wjr1 173 9 rather rather RB cord-026384-ejk9wjr1 173 10 than than IN cord-026384-ejk9wjr1 173 11 interrelated interrelated JJ cord-026384-ejk9wjr1 173 12 might may MD cord-026384-ejk9wjr1 173 13 minimize minimize VB cord-026384-ejk9wjr1 173 14 the the DT cord-026384-ejk9wjr1 173 15 impact impact NN cord-026384-ejk9wjr1 173 16 of of IN cord-026384-ejk9wjr1 173 17 contextual contextual JJ cord-026384-ejk9wjr1 173 18 information information NN cord-026384-ejk9wjr1 173 19 on on IN cord-026384-ejk9wjr1 173 20 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 173 21 outcomes outcome NNS cord-026384-ejk9wjr1 173 22 . . . cord-026384-ejk9wjr1 174 1 Model model NN cord-026384-ejk9wjr1 174 2 development development NN cord-026384-ejk9wjr1 174 3 . . . cord-026384-ejk9wjr1 175 1 Of of IN cord-026384-ejk9wjr1 175 2 the the DT cord-026384-ejk9wjr1 175 3 32 32 CD cord-026384-ejk9wjr1 175 4 papers paper NNS cord-026384-ejk9wjr1 175 5 included include VBN cord-026384-ejk9wjr1 175 6 in in IN cord-026384-ejk9wjr1 175 7 the the DT cord-026384-ejk9wjr1 175 8 review review NN cord-026384-ejk9wjr1 175 9 , , , cord-026384-ejk9wjr1 175 10 12 12 CD cord-026384-ejk9wjr1 175 11 reported report VBD cord-026384-ejk9wjr1 175 12 on on IN cord-026384-ejk9wjr1 175 13 de de NNP cord-026384-ejk9wjr1 175 14 novo novo NNP cord-026384-ejk9wjr1 175 15 risk risk NN cord-026384-ejk9wjr1 175 16 prediction prediction NN cord-026384-ejk9wjr1 175 17 tools tool NNS cord-026384-ejk9wjr1 175 18 . . . cord-026384-ejk9wjr1 176 1 The the DT cord-026384-ejk9wjr1 176 2 other other JJ cord-026384-ejk9wjr1 176 3 20 20 CD cord-026384-ejk9wjr1 176 4 studies study NNS cord-026384-ejk9wjr1 176 5 either either CC cord-026384-ejk9wjr1 176 6 evaluated evaluate VBD cord-026384-ejk9wjr1 176 7 a a DT cord-026384-ejk9wjr1 176 8 previous previous JJ cord-026384-ejk9wjr1 176 9 model model NN cord-026384-ejk9wjr1 176 10 or or CC cord-026384-ejk9wjr1 176 11 adjusted adjust VBD cord-026384-ejk9wjr1 176 12 a a DT cord-026384-ejk9wjr1 176 13 prior prior JJ cord-026384-ejk9wjr1 176 14 model model NN cord-026384-ejk9wjr1 176 15 by by IN cord-026384-ejk9wjr1 176 16 changing change VBG cord-026384-ejk9wjr1 176 17 the the DT cord-026384-ejk9wjr1 176 18 times time NNS cord-026384-ejk9wjr1 176 19 at at IN cord-026384-ejk9wjr1 176 20 which which WDT cord-026384-ejk9wjr1 176 21 data datum NNS cord-026384-ejk9wjr1 176 22 were be VBD cord-026384-ejk9wjr1 176 23 collected collect VBN cord-026384-ejk9wjr1 176 24 or or CC cord-026384-ejk9wjr1 176 25 by by IN cord-026384-ejk9wjr1 176 26 adding add VBG cord-026384-ejk9wjr1 176 27 additional additional JJ cord-026384-ejk9wjr1 176 28 variables variable NNS cord-026384-ejk9wjr1 176 29 . . . cord-026384-ejk9wjr1 177 1 The the DT cord-026384-ejk9wjr1 177 2 approach approach NN cord-026384-ejk9wjr1 177 3 to to TO cord-026384-ejk9wjr1 177 4 prediction prediction VB cord-026384-ejk9wjr1 177 5 tool tool NN cord-026384-ejk9wjr1 177 6 development development NN cord-026384-ejk9wjr1 177 7 was be VBD cord-026384-ejk9wjr1 177 8 almost almost RB cord-026384-ejk9wjr1 177 9 uniform uniform JJ cord-026384-ejk9wjr1 177 10 among among IN cord-026384-ejk9wjr1 177 11 the the DT cord-026384-ejk9wjr1 177 12 studies study NNS cord-026384-ejk9wjr1 177 13 , , , cord-026384-ejk9wjr1 177 14 with with IN cord-026384-ejk9wjr1 177 15 nine nine CD cord-026384-ejk9wjr1 177 16 of of IN cord-026384-ejk9wjr1 177 17 the the DT cord-026384-ejk9wjr1 177 18 models model NNS cord-026384-ejk9wjr1 177 19 solely solely RB cord-026384-ejk9wjr1 177 20 using use VBG cord-026384-ejk9wjr1 177 21 regression regression NN cord-026384-ejk9wjr1 177 22 techniques technique NNS cord-026384-ejk9wjr1 177 23 to to TO cord-026384-ejk9wjr1 177 24 select select VB cord-026384-ejk9wjr1 177 25 variables variable NNS cord-026384-ejk9wjr1 177 26 . . . cord-026384-ejk9wjr1 178 1 Ambalavanan Ambalavanan NNP cord-026384-ejk9wjr1 178 2 et et NNP cord-026384-ejk9wjr1 178 3 al al NNP cord-026384-ejk9wjr1 178 4 . . NNP cord-026384-ejk9wjr1 178 5 deviated deviate VBD cord-026384-ejk9wjr1 178 6 from from IN cord-026384-ejk9wjr1 178 7 this this DT cord-026384-ejk9wjr1 178 8 method method NN cord-026384-ejk9wjr1 178 9 in in IN cord-026384-ejk9wjr1 178 10 three three CD cord-026384-ejk9wjr1 178 11 separate separate JJ cord-026384-ejk9wjr1 178 12 studies study NNS cord-026384-ejk9wjr1 178 13 : : : cord-026384-ejk9wjr1 178 14 two two CD cord-026384-ejk9wjr1 178 15 using use VBG cord-026384-ejk9wjr1 178 16 classification classification NN cord-026384-ejk9wjr1 178 17 tree tree NN cord-026384-ejk9wjr1 178 18 analysis analysis NN cord-026384-ejk9wjr1 178 19 , , , cord-026384-ejk9wjr1 178 20 35 35 CD cord-026384-ejk9wjr1 178 21 , , , cord-026384-ejk9wjr1 178 22 45 45 CD cord-026384-ejk9wjr1 178 23 and and CC cord-026384-ejk9wjr1 178 24 one one CD cord-026384-ejk9wjr1 178 25 using use VBG cord-026384-ejk9wjr1 178 26 a a DT cord-026384-ejk9wjr1 178 27 four four CD cord-026384-ejk9wjr1 178 28 - - HYPH cord-026384-ejk9wjr1 178 29 layer layer NN cord-026384-ejk9wjr1 178 30 back back NN cord-026384-ejk9wjr1 178 31 - - HYPH cord-026384-ejk9wjr1 178 32 propagation propagation NN cord-026384-ejk9wjr1 178 33 neural neural JJ cord-026384-ejk9wjr1 178 34 network network NN cord-026384-ejk9wjr1 178 35 . . . cord-026384-ejk9wjr1 179 1 31 31 CD cord-026384-ejk9wjr1 180 1 Each each DT cord-026384-ejk9wjr1 180 2 new new JJ cord-026384-ejk9wjr1 180 3 model model NN cord-026384-ejk9wjr1 180 4 - - : cord-026384-ejk9wjr1 180 5 with with IN cord-026384-ejk9wjr1 180 6 the the DT cord-026384-ejk9wjr1 180 7 exception exception NN cord-026384-ejk9wjr1 180 8 of of IN cord-026384-ejk9wjr1 180 9 the the DT cord-026384-ejk9wjr1 180 10 neural neural JJ cord-026384-ejk9wjr1 180 11 networkbased networkbased JJ cord-026384-ejk9wjr1 180 12 model model NN cord-026384-ejk9wjr1 180 13 by by IN cord-026384-ejk9wjr1 180 14 Ambalavanan Ambalavanan NNP cord-026384-ejk9wjr1 180 15 et et NNP cord-026384-ejk9wjr1 180 16 al al NNP cord-026384-ejk9wjr1 180 17 . . . cord-026384-ejk9wjr1 181 1 35 35 CD cord-026384-ejk9wjr1 181 2 , , , cord-026384-ejk9wjr1 181 3 45 45 CD cord-026384-ejk9wjr1 181 4 -depended -depende VBN cord-026384-ejk9wjr1 182 1 on on IN cord-026384-ejk9wjr1 182 2 an an DT cord-026384-ejk9wjr1 182 3 approach approach NN cord-026384-ejk9wjr1 182 4 in in IN cord-026384-ejk9wjr1 182 5 which which WDT cord-026384-ejk9wjr1 182 6 individual individual JJ cord-026384-ejk9wjr1 182 7 variables variable NNS cord-026384-ejk9wjr1 182 8 were be VBD cord-026384-ejk9wjr1 182 9 selected select VBN cord-026384-ejk9wjr1 182 10 and and CC cord-026384-ejk9wjr1 182 11 treated treat VBN cord-026384-ejk9wjr1 182 12 as as IN cord-026384-ejk9wjr1 182 13 independent independent JJ cord-026384-ejk9wjr1 182 14 of of IN cord-026384-ejk9wjr1 182 15 one one CD cord-026384-ejk9wjr1 182 16 another another DT cord-026384-ejk9wjr1 182 17 as as IN cord-026384-ejk9wjr1 182 18 they -PRON- PRP cord-026384-ejk9wjr1 182 19 were be VBD cord-026384-ejk9wjr1 182 20 analyzed analyze VBN cord-026384-ejk9wjr1 182 21 in in IN cord-026384-ejk9wjr1 182 22 their -PRON- PRP$ cord-026384-ejk9wjr1 182 23 ability ability NN cord-026384-ejk9wjr1 182 24 to to TO cord-026384-ejk9wjr1 182 25 predict predict VB cord-026384-ejk9wjr1 182 26 the the DT cord-026384-ejk9wjr1 182 27 outcome outcome NN cord-026384-ejk9wjr1 182 28 of of IN cord-026384-ejk9wjr1 182 29 interest interest NN cord-026384-ejk9wjr1 182 30 . . . cord-026384-ejk9wjr1 183 1 Yet yet RB cord-026384-ejk9wjr1 183 2 , , , cord-026384-ejk9wjr1 183 3 variables variable NNS cord-026384-ejk9wjr1 183 4 may may MD cord-026384-ejk9wjr1 183 5 , , , cord-026384-ejk9wjr1 183 6 in in IN cord-026384-ejk9wjr1 183 7 fact fact NN cord-026384-ejk9wjr1 183 8 , , , cord-026384-ejk9wjr1 183 9 not not RB cord-026384-ejk9wjr1 183 10 act act VB cord-026384-ejk9wjr1 183 11 independently independently RB cord-026384-ejk9wjr1 183 12 . . . cord-026384-ejk9wjr1 184 1 While while IN cord-026384-ejk9wjr1 184 2 parsing parse VBG cord-026384-ejk9wjr1 184 3 the the DT cord-026384-ejk9wjr1 184 4 roles role NNS cord-026384-ejk9wjr1 184 5 of of IN cord-026384-ejk9wjr1 184 6 potential potential JJ cord-026384-ejk9wjr1 184 7 interrelationships interrelationship NNS cord-026384-ejk9wjr1 184 8 may may MD cord-026384-ejk9wjr1 184 9 be be VB cord-026384-ejk9wjr1 184 10 computationally computationally RB cord-026384-ejk9wjr1 184 11 onerous onerous JJ cord-026384-ejk9wjr1 184 12 and and CC cord-026384-ejk9wjr1 184 13 treating treat VBG cord-026384-ejk9wjr1 184 14 them -PRON- PRP cord-026384-ejk9wjr1 184 15 independently independently RB cord-026384-ejk9wjr1 184 16 may may MD cord-026384-ejk9wjr1 184 17 lead lead VB cord-026384-ejk9wjr1 184 18 to to IN cord-026384-ejk9wjr1 184 19 a a DT cord-026384-ejk9wjr1 184 20 more more RBR cord-026384-ejk9wjr1 184 21 parsimonious parsimonious JJ cord-026384-ejk9wjr1 184 22 model model NN cord-026384-ejk9wjr1 184 23 , , , cord-026384-ejk9wjr1 184 24 this this DT cord-026384-ejk9wjr1 184 25 may may MD cord-026384-ejk9wjr1 184 26 be be VB cord-026384-ejk9wjr1 184 27 at at IN cord-026384-ejk9wjr1 184 28 the the DT cord-026384-ejk9wjr1 184 29 expense expense NN cord-026384-ejk9wjr1 184 30 of of IN cord-026384-ejk9wjr1 184 31 accuracy accuracy NN cord-026384-ejk9wjr1 184 32 . . . cord-026384-ejk9wjr1 185 1 Alternative alternative JJ cord-026384-ejk9wjr1 185 2 computational computational JJ cord-026384-ejk9wjr1 185 3 approaches approach NNS cord-026384-ejk9wjr1 185 4 are be VBP cord-026384-ejk9wjr1 185 5 needed need VBN cord-026384-ejk9wjr1 185 6 to to TO cord-026384-ejk9wjr1 185 7 account account VB cord-026384-ejk9wjr1 185 8 for for IN cord-026384-ejk9wjr1 185 9 the the DT cord-026384-ejk9wjr1 185 10 differential differential JJ cord-026384-ejk9wjr1 185 11 likelihoods likelihood NNS cord-026384-ejk9wjr1 185 12 of of IN cord-026384-ejk9wjr1 185 13 certain certain JJ cord-026384-ejk9wjr1 185 14 outcomes outcome NNS cord-026384-ejk9wjr1 185 15 on on IN cord-026384-ejk9wjr1 185 16 the the DT cord-026384-ejk9wjr1 185 17 causal causal JJ cord-026384-ejk9wjr1 185 18 pathway pathway NN cord-026384-ejk9wjr1 185 19 from from IN cord-026384-ejk9wjr1 185 20 preterm preterm JJR cord-026384-ejk9wjr1 185 21 birth birth NN cord-026384-ejk9wjr1 185 22 to to IN cord-026384-ejk9wjr1 185 23 later later RB cord-026384-ejk9wjr1 185 24 childhood childhood NN cord-026384-ejk9wjr1 185 25 outcome outcome NN cord-026384-ejk9wjr1 185 26 . . . cord-026384-ejk9wjr1 186 1 Nonlinear nonlinear JJ cord-026384-ejk9wjr1 186 2 statistical statistical JJ cord-026384-ejk9wjr1 186 3 tools tool NNS cord-026384-ejk9wjr1 186 4 should should MD cord-026384-ejk9wjr1 186 5 be be VB cord-026384-ejk9wjr1 186 6 further further RB cord-026384-ejk9wjr1 186 7 utilized utilize VBN cord-026384-ejk9wjr1 186 8 in in IN cord-026384-ejk9wjr1 186 9 risk risk NN cord-026384-ejk9wjr1 186 10 prediction prediction NN cord-026384-ejk9wjr1 186 11 model model NN cord-026384-ejk9wjr1 186 12 development development NN cord-026384-ejk9wjr1 186 13 to to TO cord-026384-ejk9wjr1 186 14 examine examine VB cord-026384-ejk9wjr1 186 15 the the DT cord-026384-ejk9wjr1 186 16 relationships relationship NNS cord-026384-ejk9wjr1 186 17 between between IN cord-026384-ejk9wjr1 186 18 variables variable NNS cord-026384-ejk9wjr1 186 19 and and CC cord-026384-ejk9wjr1 186 20 outcomes outcome NNS cord-026384-ejk9wjr1 186 21 of of IN cord-026384-ejk9wjr1 186 22 interest interest NN cord-026384-ejk9wjr1 186 23 . . . cord-026384-ejk9wjr1 187 1 Machine machine NN cord-026384-ejk9wjr1 187 2 learning learning NN cord-026384-ejk9wjr1 187 3 , , , cord-026384-ejk9wjr1 187 4 for for IN cord-026384-ejk9wjr1 187 5 instance instance NN cord-026384-ejk9wjr1 187 6 , , , cord-026384-ejk9wjr1 187 7 is be VBZ cord-026384-ejk9wjr1 187 8 a a DT cord-026384-ejk9wjr1 187 9 method method NN cord-026384-ejk9wjr1 187 10 of of IN cord-026384-ejk9wjr1 187 11 inputting inputte VBG cord-026384-ejk9wjr1 187 12 a a DT cord-026384-ejk9wjr1 187 13 group group NN cord-026384-ejk9wjr1 187 14 of of IN cord-026384-ejk9wjr1 187 15 variables variable NNS cord-026384-ejk9wjr1 187 16 and and CC cord-026384-ejk9wjr1 187 17 generating generate VBG cord-026384-ejk9wjr1 187 18 a a DT cord-026384-ejk9wjr1 187 19 predictive predictive JJ cord-026384-ejk9wjr1 187 20 model model NN cord-026384-ejk9wjr1 187 21 without without IN cord-026384-ejk9wjr1 187 22 making make VBG cord-026384-ejk9wjr1 187 23 assumptions assumption NNS cord-026384-ejk9wjr1 187 24 of of IN cord-026384-ejk9wjr1 187 25 independence independence NN cord-026384-ejk9wjr1 187 26 between between IN cord-026384-ejk9wjr1 187 27 the the DT cord-026384-ejk9wjr1 187 28 factors factor NNS cord-026384-ejk9wjr1 187 29 or or CC cord-026384-ejk9wjr1 187 30 that that IN cord-026384-ejk9wjr1 187 31 specific specific JJ cord-026384-ejk9wjr1 187 32 factors factor NNS cord-026384-ejk9wjr1 187 33 would would MD cord-026384-ejk9wjr1 187 34 contribute contribute VB cord-026384-ejk9wjr1 187 35 the the DT cord-026384-ejk9wjr1 187 36 most most JJS cord-026384-ejk9wjr1 187 37 to to IN cord-026384-ejk9wjr1 187 38 the the DT cord-026384-ejk9wjr1 187 39 model model NN cord-026384-ejk9wjr1 187 40 . . . cord-026384-ejk9wjr1 188 1 88 88 CD cord-026384-ejk9wjr1 189 1 Different different JJ cord-026384-ejk9wjr1 189 2 forms form NNS cord-026384-ejk9wjr1 189 3 of of IN cord-026384-ejk9wjr1 189 4 machine machine NN cord-026384-ejk9wjr1 189 5 learning learning NN cord-026384-ejk9wjr1 189 6 have have VBP cord-026384-ejk9wjr1 189 7 already already RB cord-026384-ejk9wjr1 189 8 been be VBN cord-026384-ejk9wjr1 189 9 employed employ VBN cord-026384-ejk9wjr1 189 10 in in IN cord-026384-ejk9wjr1 189 11 NICU NICU NNP cord-026384-ejk9wjr1 189 12 's 's POS cord-026384-ejk9wjr1 189 13 to to TO cord-026384-ejk9wjr1 189 14 extract extract VB cord-026384-ejk9wjr1 189 15 the the DT cord-026384-ejk9wjr1 189 16 most most RBS cord-026384-ejk9wjr1 189 17 important important JJ cord-026384-ejk9wjr1 189 18 variables variable NNS cord-026384-ejk9wjr1 189 19 for for IN cord-026384-ejk9wjr1 189 20 predicting predict VBG cord-026384-ejk9wjr1 189 21 outcomes outcome NNS cord-026384-ejk9wjr1 189 22 such such JJ cord-026384-ejk9wjr1 189 23 as as IN cord-026384-ejk9wjr1 189 24 days day NNS cord-026384-ejk9wjr1 189 25 to to TO cord-026384-ejk9wjr1 189 26 discharge discharge VB cord-026384-ejk9wjr1 189 27 . . . cord-026384-ejk9wjr1 190 1 89 89 CD cord-026384-ejk9wjr1 191 1 The the DT cord-026384-ejk9wjr1 191 2 non non JJ cord-026384-ejk9wjr1 191 3 - - JJ cord-026384-ejk9wjr1 191 4 independence independence NN cord-026384-ejk9wjr1 191 5 of of IN cord-026384-ejk9wjr1 191 6 risk risk NN cord-026384-ejk9wjr1 191 7 factors factor NNS cord-026384-ejk9wjr1 191 8 is be VBZ cord-026384-ejk9wjr1 191 9 also also RB cord-026384-ejk9wjr1 191 10 complicated complicate VBN cord-026384-ejk9wjr1 191 11 by by IN cord-026384-ejk9wjr1 191 12 the the DT cord-026384-ejk9wjr1 191 13 role role NN cord-026384-ejk9wjr1 191 14 of of IN cord-026384-ejk9wjr1 191 15 time time NN cord-026384-ejk9wjr1 191 16 in in IN cord-026384-ejk9wjr1 191 17 models model NNS cord-026384-ejk9wjr1 191 18 of of IN cord-026384-ejk9wjr1 191 19 human human JJ cord-026384-ejk9wjr1 191 20 health health NN cord-026384-ejk9wjr1 191 21 and and CC cord-026384-ejk9wjr1 191 22 development development NN cord-026384-ejk9wjr1 191 23 . . . cord-026384-ejk9wjr1 192 1 The the DT cord-026384-ejk9wjr1 192 2 lifecourse lifecourse NNP cord-026384-ejk9wjr1 192 3 framework framework NN cord-026384-ejk9wjr1 192 4 describes describe VBZ cord-026384-ejk9wjr1 192 5 how how WRB cord-026384-ejk9wjr1 192 6 an an DT cord-026384-ejk9wjr1 192 7 accumulation accumulation NN cord-026384-ejk9wjr1 192 8 or or CC cord-026384-ejk9wjr1 192 9 " " `` cord-026384-ejk9wjr1 192 10 chains chain NNS cord-026384-ejk9wjr1 192 11 " " '' cord-026384-ejk9wjr1 192 12 of of IN cord-026384-ejk9wjr1 192 13 risk risk NN cord-026384-ejk9wjr1 192 14 experienced experience VBN cord-026384-ejk9wjr1 192 15 over over IN cord-026384-ejk9wjr1 192 16 time time NN cord-026384-ejk9wjr1 192 17 and and CC cord-026384-ejk9wjr1 192 18 at at IN cord-026384-ejk9wjr1 192 19 certain certain JJ cord-026384-ejk9wjr1 192 20 critical critical JJ cord-026384-ejk9wjr1 192 21 periods period NNS cord-026384-ejk9wjr1 192 22 impact impact NN cord-026384-ejk9wjr1 192 23 later later RB cord-026384-ejk9wjr1 192 24 health health NN cord-026384-ejk9wjr1 192 25 outcomes outcome NNS cord-026384-ejk9wjr1 192 26 . . . cord-026384-ejk9wjr1 193 1 90 90 CD cord-026384-ejk9wjr1 194 1 In in IN cord-026384-ejk9wjr1 194 2 the the DT cord-026384-ejk9wjr1 194 3 context context NN cord-026384-ejk9wjr1 194 4 of of IN cord-026384-ejk9wjr1 194 5 preterm preterm JJ cord-026384-ejk9wjr1 194 6 birth birth NN cord-026384-ejk9wjr1 194 7 , , , cord-026384-ejk9wjr1 194 8 the the DT cord-026384-ejk9wjr1 194 9 risk risk NN cord-026384-ejk9wjr1 194 10 of of IN cord-026384-ejk9wjr1 194 11 being be VBG cord-026384-ejk9wjr1 194 12 born bear VBN cord-026384-ejk9wjr1 194 13 early early RB cord-026384-ejk9wjr1 194 14 is be VBZ cord-026384-ejk9wjr1 194 15 not not RB cord-026384-ejk9wjr1 194 16 uniform uniform JJ cord-026384-ejk9wjr1 194 17 across across IN cord-026384-ejk9wjr1 194 18 populations population NNS cord-026384-ejk9wjr1 194 19 and and CC cord-026384-ejk9wjr1 194 20 dependent dependent JJ cord-026384-ejk9wjr1 194 21 on on IN cord-026384-ejk9wjr1 194 22 a a DT cord-026384-ejk9wjr1 194 23 given give VBN cord-026384-ejk9wjr1 194 24 set set NN cord-026384-ejk9wjr1 194 25 of of IN cord-026384-ejk9wjr1 194 26 maternal maternal JJ cord-026384-ejk9wjr1 194 27 risks risk NNS cord-026384-ejk9wjr1 194 28 . . . cord-026384-ejk9wjr1 195 1 In in IN cord-026384-ejk9wjr1 195 2 turn turn NN cord-026384-ejk9wjr1 195 3 , , , cord-026384-ejk9wjr1 195 4 the the DT cord-026384-ejk9wjr1 195 5 degree degree NN cord-026384-ejk9wjr1 195 6 of of IN cord-026384-ejk9wjr1 195 7 prematurity prematurity NN cord-026384-ejk9wjr1 195 8 imparts impart VBZ cord-026384-ejk9wjr1 195 9 differential differential JJ cord-026384-ejk9wjr1 195 10 risk risk NN cord-026384-ejk9wjr1 195 11 for for IN cord-026384-ejk9wjr1 195 12 developing develop VBG cord-026384-ejk9wjr1 195 13 complications complication NNS cord-026384-ejk9wjr1 195 14 such such JJ cord-026384-ejk9wjr1 195 15 as as IN cord-026384-ejk9wjr1 195 16 bronchopulmonary bronchopulmonary JJ cord-026384-ejk9wjr1 195 17 dysplasia dysplasia NN cord-026384-ejk9wjr1 195 18 , , , cord-026384-ejk9wjr1 195 19 necrotizing necrotize VBG cord-026384-ejk9wjr1 195 20 enterocolitis enterocolitis NN cord-026384-ejk9wjr1 195 21 , , , cord-026384-ejk9wjr1 195 22 or or CC cord-026384-ejk9wjr1 195 23 retinopathy retinopathy NN cord-026384-ejk9wjr1 195 24 of of IN cord-026384-ejk9wjr1 195 25 prematurity prematurity NN cord-026384-ejk9wjr1 195 26 . . . cord-026384-ejk9wjr1 196 1 These these DT cord-026384-ejk9wjr1 196 2 morbidities morbidity NNS cord-026384-ejk9wjr1 196 3 then then RB cord-026384-ejk9wjr1 196 4 , , , cord-026384-ejk9wjr1 196 5 in in IN cord-026384-ejk9wjr1 196 6 turn turn NN cord-026384-ejk9wjr1 196 7 , , , cord-026384-ejk9wjr1 196 8 increase increase VB cord-026384-ejk9wjr1 196 9 risks risk NNS cord-026384-ejk9wjr1 196 10 for for IN cord-026384-ejk9wjr1 196 11 further further JJ cord-026384-ejk9wjr1 196 12 medical medical JJ cord-026384-ejk9wjr1 196 13 and and CC cord-026384-ejk9wjr1 196 14 developmental developmental JJ cord-026384-ejk9wjr1 196 15 impairment impairment NN cord-026384-ejk9wjr1 196 16 . . . cord-026384-ejk9wjr1 197 1 These these DT cord-026384-ejk9wjr1 197 2 time time NN cord-026384-ejk9wjr1 197 3 - - HYPH cord-026384-ejk9wjr1 197 4 varying vary VBG cord-026384-ejk9wjr1 197 5 probabilities probability NNS cord-026384-ejk9wjr1 197 6 can can MD cord-026384-ejk9wjr1 197 7 be be VB cord-026384-ejk9wjr1 197 8 modeled model VBN cord-026384-ejk9wjr1 197 9 and and CC cord-026384-ejk9wjr1 197 10 incorporated incorporate VBN cord-026384-ejk9wjr1 197 11 into into IN cord-026384-ejk9wjr1 197 12 prediction prediction NN cord-026384-ejk9wjr1 197 13 tools tool NNS cord-026384-ejk9wjr1 197 14 to to IN cord-026384-ejk9wjr1 197 15 more more RBR cord-026384-ejk9wjr1 197 16 accurately accurately RB cord-026384-ejk9wjr1 197 17 capture capture VB cord-026384-ejk9wjr1 197 18 the the DT cord-026384-ejk9wjr1 197 19 longitudinal longitudinal JJ cord-026384-ejk9wjr1 197 20 and and CC cord-026384-ejk9wjr1 197 21 varying vary VBG cord-026384-ejk9wjr1 197 22 relationships relationship NNS cord-026384-ejk9wjr1 197 23 between between IN cord-026384-ejk9wjr1 197 24 exposures exposure NNS cord-026384-ejk9wjr1 197 25 and and CC cord-026384-ejk9wjr1 197 26 outcomes outcome NNS cord-026384-ejk9wjr1 197 27 and and CC cord-026384-ejk9wjr1 197 28 improve improve VB cord-026384-ejk9wjr1 197 29 thereby thereby RB cord-026384-ejk9wjr1 197 30 estimations estimation NNS cord-026384-ejk9wjr1 197 31 of of IN cord-026384-ejk9wjr1 197 32 risk risk NN cord-026384-ejk9wjr1 197 33 . . . cord-026384-ejk9wjr1 198 1 [ [ -LRB- cord-026384-ejk9wjr1 198 2 91 91 CD cord-026384-ejk9wjr1 198 3 ] ] -RRB- cord-026384-ejk9wjr1 198 4 [ [ -LRB- cord-026384-ejk9wjr1 198 5 92 92 CD cord-026384-ejk9wjr1 198 6 ] ] -RRB- cord-026384-ejk9wjr1 199 1 [ [ -LRB- cord-026384-ejk9wjr1 199 2 93 93 CD cord-026384-ejk9wjr1 199 3 ] ] -RRB- cord-026384-ejk9wjr1 200 1 A a DT cord-026384-ejk9wjr1 200 2 final final JJ cord-026384-ejk9wjr1 200 3 methodological methodological JJ cord-026384-ejk9wjr1 200 4 concern concern NN cord-026384-ejk9wjr1 200 5 regarding regard VBG cord-026384-ejk9wjr1 200 6 model model NN cord-026384-ejk9wjr1 200 7 development development NN cord-026384-ejk9wjr1 200 8 is be VBZ cord-026384-ejk9wjr1 200 9 whether whether IN cord-026384-ejk9wjr1 200 10 and and CC cord-026384-ejk9wjr1 200 11 how how WRB cord-026384-ejk9wjr1 200 12 the the DT cord-026384-ejk9wjr1 200 13 competing compete VBG cord-026384-ejk9wjr1 200 14 risk risk NN cord-026384-ejk9wjr1 200 15 of of IN cord-026384-ejk9wjr1 200 16 death death NN cord-026384-ejk9wjr1 200 17 is be VBZ cord-026384-ejk9wjr1 200 18 considered consider VBN cord-026384-ejk9wjr1 200 19 when when WRB cord-026384-ejk9wjr1 200 20 the the DT cord-026384-ejk9wjr1 200 21 outcome outcome NN cord-026384-ejk9wjr1 200 22 being be VBG cord-026384-ejk9wjr1 200 23 predicted predict VBN cord-026384-ejk9wjr1 200 24 is be VBZ cord-026384-ejk9wjr1 200 25 non non JJ cord-026384-ejk9wjr1 200 26 - - JJ cord-026384-ejk9wjr1 200 27 terminal terminal JJ cord-026384-ejk9wjr1 200 28 . . . cord-026384-ejk9wjr1 201 1 Consider consider VB cord-026384-ejk9wjr1 201 2 , , , cord-026384-ejk9wjr1 201 3 for for IN cord-026384-ejk9wjr1 201 4 example example NN cord-026384-ejk9wjr1 201 5 , , , cord-026384-ejk9wjr1 201 6 the the DT cord-026384-ejk9wjr1 201 7 task task NN cord-026384-ejk9wjr1 201 8 of of IN cord-026384-ejk9wjr1 201 9 developing develop VBG cord-026384-ejk9wjr1 201 10 a a DT cord-026384-ejk9wjr1 201 11 model model NN cord-026384-ejk9wjr1 201 12 for for IN cord-026384-ejk9wjr1 201 13 the the DT cord-026384-ejk9wjr1 201 14 risk risk NN cord-026384-ejk9wjr1 201 15 of of IN cord-026384-ejk9wjr1 201 16 NDI NDI NNP cord-026384-ejk9wjr1 201 17 at at IN cord-026384-ejk9wjr1 201 18 10 10 CD cord-026384-ejk9wjr1 201 19 years year NNS cord-026384-ejk9wjr1 201 20 of of IN cord-026384-ejk9wjr1 201 21 age age NN cord-026384-ejk9wjr1 201 22 . . . cord-026384-ejk9wjr1 202 1 How how WRB cord-026384-ejk9wjr1 202 2 one one PRP cord-026384-ejk9wjr1 202 3 handles handle VBZ cord-026384-ejk9wjr1 202 4 death death NN cord-026384-ejk9wjr1 202 5 can can MD cord-026384-ejk9wjr1 202 6 have have VB cord-026384-ejk9wjr1 202 7 a a DT cord-026384-ejk9wjr1 202 8 dramatic dramatic JJ cord-026384-ejk9wjr1 202 9 effect effect NN cord-026384-ejk9wjr1 202 10 on on IN cord-026384-ejk9wjr1 202 11 the the DT cord-026384-ejk9wjr1 202 12 model model NN cord-026384-ejk9wjr1 202 13 , , , cord-026384-ejk9wjr1 202 14 especially especially RB cord-026384-ejk9wjr1 202 15 since since IN cord-026384-ejk9wjr1 202 16 mortality mortality NN cord-026384-ejk9wjr1 202 17 is be VBZ cord-026384-ejk9wjr1 202 18 relatively relatively RB cord-026384-ejk9wjr1 202 19 high high JJ cord-026384-ejk9wjr1 202 20 among among IN cord-026384-ejk9wjr1 202 21 preterm preterm JJ cord-026384-ejk9wjr1 202 22 infants infant NNS cord-026384-ejk9wjr1 202 23 . . . cord-026384-ejk9wjr1 203 1 Moreover moreover RB cord-026384-ejk9wjr1 203 2 , , , cord-026384-ejk9wjr1 203 3 if if IN cord-026384-ejk9wjr1 203 4 death death NN cord-026384-ejk9wjr1 203 5 is be VBZ cord-026384-ejk9wjr1 203 6 treated treat VBN cord-026384-ejk9wjr1 203 7 simply simply RB cord-026384-ejk9wjr1 203 8 as as IN cord-026384-ejk9wjr1 203 9 a a DT cord-026384-ejk9wjr1 203 10 censoring censoring NN cord-026384-ejk9wjr1 203 11 mechanism mechanism NN cord-026384-ejk9wjr1 203 12 , , , cord-026384-ejk9wjr1 203 13 as as IN cord-026384-ejk9wjr1 203 14 it -PRON- PRP cord-026384-ejk9wjr1 203 15 is be VBZ cord-026384-ejk9wjr1 203 16 often often RB cord-026384-ejk9wjr1 203 17 done do VBN cord-026384-ejk9wjr1 203 18 in in IN cord-026384-ejk9wjr1 203 19 time time NN cord-026384-ejk9wjr1 203 20 - - HYPH cord-026384-ejk9wjr1 203 21 to to IN cord-026384-ejk9wjr1 203 22 - - HYPH cord-026384-ejk9wjr1 203 23 event event NN cord-026384-ejk9wjr1 203 24 analyses analysis NNS cord-026384-ejk9wjr1 203 25 such such JJ cord-026384-ejk9wjr1 203 26 as as IN cord-026384-ejk9wjr1 203 27 those those DT cord-026384-ejk9wjr1 203 28 based base VBN cord-026384-ejk9wjr1 203 29 on on IN cord-026384-ejk9wjr1 203 30 the the DT cord-026384-ejk9wjr1 203 31 Cox Cox NNP cord-026384-ejk9wjr1 203 32 model model NN cord-026384-ejk9wjr1 203 33 , , , cord-026384-ejk9wjr1 203 34 then then RB cord-026384-ejk9wjr1 203 35 the the DT cord-026384-ejk9wjr1 203 36 overall overall JJ cord-026384-ejk9wjr1 203 37 risk risk NN cord-026384-ejk9wjr1 203 38 of of IN cord-026384-ejk9wjr1 203 39 NDI NDI NNP cord-026384-ejk9wjr1 203 40 will will MD cord-026384-ejk9wjr1 203 41 be be VB cord-026384-ejk9wjr1 203 42 artificially artificially RB cord-026384-ejk9wjr1 203 43 reduced reduce VBN cord-026384-ejk9wjr1 203 44 ; ; : cord-026384-ejk9wjr1 203 45 those those DT cord-026384-ejk9wjr1 203 46 children child NNS cord-026384-ejk9wjr1 203 47 who who WP cord-026384-ejk9wjr1 203 48 die die VBP cord-026384-ejk9wjr1 203 49 before before IN cord-026384-ejk9wjr1 203 50 being be VBG cord-026384-ejk9wjr1 203 51 diagnosed diagnose VBN cord-026384-ejk9wjr1 203 52 with with IN cord-026384-ejk9wjr1 203 53 NDI NDI NNP cord-026384-ejk9wjr1 203 54 will will MD cord-026384-ejk9wjr1 203 55 be be VB cord-026384-ejk9wjr1 203 56 viewed view VBN cord-026384-ejk9wjr1 203 57 as as IN cord-026384-ejk9wjr1 203 58 remaining remain VBG cord-026384-ejk9wjr1 203 59 at at IN cord-026384-ejk9wjr1 203 60 risk risk NN cord-026384-ejk9wjr1 203 61 even even RB cord-026384-ejk9wjr1 203 62 though though IN cord-026384-ejk9wjr1 203 63 they -PRON- PRP cord-026384-ejk9wjr1 203 64 can can MD cord-026384-ejk9wjr1 203 65 not not RB cord-026384-ejk9wjr1 203 66 possibly possibly RB cord-026384-ejk9wjr1 203 67 be be VB cord-026384-ejk9wjr1 203 68 subsequently subsequently RB cord-026384-ejk9wjr1 203 69 diagnosed diagnose VBN cord-026384-ejk9wjr1 203 70 with with IN cord-026384-ejk9wjr1 203 71 NDI NDI NNP cord-026384-ejk9wjr1 203 72 . . . cord-026384-ejk9wjr1 204 1 While while IN cord-026384-ejk9wjr1 204 2 an an DT cord-026384-ejk9wjr1 204 3 alternative alternative NN cord-026384-ejk9wjr1 204 4 to to IN cord-026384-ejk9wjr1 204 5 this this DT cord-026384-ejk9wjr1 204 6 would would MD cord-026384-ejk9wjr1 204 7 be be VB cord-026384-ejk9wjr1 204 8 to to TO cord-026384-ejk9wjr1 204 9 use use VB cord-026384-ejk9wjr1 204 10 a a DT cord-026384-ejk9wjr1 204 11 composite composite JJ cord-026384-ejk9wjr1 204 12 outcome outcome NN cord-026384-ejk9wjr1 204 13 of of IN cord-026384-ejk9wjr1 204 14 time time NN cord-026384-ejk9wjr1 204 15 the the DT cord-026384-ejk9wjr1 204 16 first first JJ cord-026384-ejk9wjr1 204 17 of of IN cord-026384-ejk9wjr1 204 18 NDI NDI NNP cord-026384-ejk9wjr1 204 19 or or CC cord-026384-ejk9wjr1 204 20 death death NN cord-026384-ejk9wjr1 204 21 , , , cord-026384-ejk9wjr1 204 22 doing do VBG cord-026384-ejk9wjr1 204 23 so so RB cord-026384-ejk9wjr1 204 24 may may MD cord-026384-ejk9wjr1 204 25 result result VB cord-026384-ejk9wjr1 204 26 in in IN cord-026384-ejk9wjr1 204 27 a a DT cord-026384-ejk9wjr1 204 28 model model NN cord-026384-ejk9wjr1 204 29 that that WDT cord-026384-ejk9wjr1 204 30 is be VBZ cord-026384-ejk9wjr1 204 31 unable unable JJ cord-026384-ejk9wjr1 204 32 to to TO cord-026384-ejk9wjr1 204 33 predict predict VB cord-026384-ejk9wjr1 204 34 either either DT cord-026384-ejk9wjr1 204 35 event event NN cord-026384-ejk9wjr1 204 36 well well RB cord-026384-ejk9wjr1 204 37 . . . cord-026384-ejk9wjr1 205 1 Instead instead RB cord-026384-ejk9wjr1 205 2 , , , cord-026384-ejk9wjr1 205 3 one one CD cord-026384-ejk9wjr1 205 4 promising promise VBG cord-026384-ejk9wjr1 205 5 avenue avenue NN cord-026384-ejk9wjr1 205 6 is be VBZ cord-026384-ejk9wjr1 205 7 to to TO cord-026384-ejk9wjr1 205 8 frame frame VB cord-026384-ejk9wjr1 205 9 the the DT cord-026384-ejk9wjr1 205 10 development development NN cord-026384-ejk9wjr1 205 11 of of IN cord-026384-ejk9wjr1 205 12 a a DT cord-026384-ejk9wjr1 205 13 prediction prediction NN cord-026384-ejk9wjr1 205 14 model model NN cord-026384-ejk9wjr1 205 15 for for IN cord-026384-ejk9wjr1 205 16 NDI NDI NNP cord-026384-ejk9wjr1 205 17 within within IN cord-026384-ejk9wjr1 205 18 the the DT cord-026384-ejk9wjr1 205 19 semi semi RB cord-026384-ejk9wjr1 205 20 - - JJ cord-026384-ejk9wjr1 205 21 competing competing JJ cord-026384-ejk9wjr1 205 22 risks risk NNS cord-026384-ejk9wjr1 205 23 paradigm paradigm NN cord-026384-ejk9wjr1 205 24 . . . cord-026384-ejk9wjr1 206 1 94 94 CD cord-026384-ejk9wjr1 206 2 , , , cord-026384-ejk9wjr1 206 3 95 95 CD cord-026384-ejk9wjr1 207 1 Briefly briefly RB cord-026384-ejk9wjr1 207 2 , , , cord-026384-ejk9wjr1 207 3 semicompeting semicompeting NN cord-026384-ejk9wjr1 207 4 risks risk NNS cord-026384-ejk9wjr1 207 5 refer refer VBP cord-026384-ejk9wjr1 207 6 to to IN cord-026384-ejk9wjr1 207 7 settings setting NNS cord-026384-ejk9wjr1 207 8 where where WRB cord-026384-ejk9wjr1 207 9 one one CD cord-026384-ejk9wjr1 207 10 event event NN cord-026384-ejk9wjr1 207 11 is be VBZ cord-026384-ejk9wjr1 207 12 a a DT cord-026384-ejk9wjr1 207 13 competing compete VBG cord-026384-ejk9wjr1 207 14 risk risk NN cord-026384-ejk9wjr1 207 15 for for IN cord-026384-ejk9wjr1 207 16 the the DT cord-026384-ejk9wjr1 207 17 other other JJ cord-026384-ejk9wjr1 207 18 , , , cord-026384-ejk9wjr1 207 19 but but CC cord-026384-ejk9wjr1 207 20 not not RB cord-026384-ejk9wjr1 207 21 vice vice RB cord-026384-ejk9wjr1 207 22 versa versa RB cord-026384-ejk9wjr1 207 23 . . . cord-026384-ejk9wjr1 208 1 This this DT cord-026384-ejk9wjr1 208 2 is be VBZ cord-026384-ejk9wjr1 208 3 distinct distinct JJ cord-026384-ejk9wjr1 208 4 from from IN cord-026384-ejk9wjr1 208 5 standard standard JJ cord-026384-ejk9wjr1 208 6 competing compete VBG cord-026384-ejk9wjr1 208 7 risks risk NNS cord-026384-ejk9wjr1 208 8 , , , cord-026384-ejk9wjr1 208 9 where where WRB cord-026384-ejk9wjr1 208 10 each each DT cord-026384-ejk9wjr1 208 11 event event NN cord-026384-ejk9wjr1 208 12 is be VBZ cord-026384-ejk9wjr1 208 13 competing compete VBG cord-026384-ejk9wjr1 208 14 for for IN cord-026384-ejk9wjr1 208 15 the the DT cord-026384-ejk9wjr1 208 16 other other JJ cord-026384-ejk9wjr1 208 17 ( ( -LRB- cord-026384-ejk9wjr1 208 18 e.g. e.g. RB cord-026384-ejk9wjr1 208 19 , , , cord-026384-ejk9wjr1 208 20 death death NN cord-026384-ejk9wjr1 208 21 due due IN cord-026384-ejk9wjr1 208 22 to to IN cord-026384-ejk9wjr1 208 23 one one CD cord-026384-ejk9wjr1 208 24 cause cause NN cord-026384-ejk9wjr1 208 25 or or CC cord-026384-ejk9wjr1 208 26 another another DT cord-026384-ejk9wjr1 208 27 ) ) -RRB- cord-026384-ejk9wjr1 208 28 . . . cord-026384-ejk9wjr1 209 1 To to IN cord-026384-ejk9wjr1 209 2 the the DT cord-026384-ejk9wjr1 209 3 best good JJS cord-026384-ejk9wjr1 209 4 of of IN cord-026384-ejk9wjr1 209 5 our -PRON- PRP$ cord-026384-ejk9wjr1 209 6 knowledge knowledge NN cord-026384-ejk9wjr1 209 7 , , , cord-026384-ejk9wjr1 209 8 however however RB cord-026384-ejk9wjr1 209 9 , , , cord-026384-ejk9wjr1 209 10 semi semi JJ cord-026384-ejk9wjr1 209 11 - - JJ cord-026384-ejk9wjr1 209 12 competing competing JJ cord-026384-ejk9wjr1 209 13 risks risk NNS cord-026384-ejk9wjr1 209 14 have have VBP cord-026384-ejk9wjr1 209 15 not not RB cord-026384-ejk9wjr1 209 16 been be VBN cord-026384-ejk9wjr1 209 17 applied apply VBN cord-026384-ejk9wjr1 209 18 to to IN cord-026384-ejk9wjr1 209 19 the the DT cord-026384-ejk9wjr1 209 20 study study NN cord-026384-ejk9wjr1 209 21 of of IN cord-026384-ejk9wjr1 209 22 long long JJ cord-026384-ejk9wjr1 209 23 - - HYPH cord-026384-ejk9wjr1 209 24 term term NN cord-026384-ejk9wjr1 209 25 outcomes outcome NNS cord-026384-ejk9wjr1 209 26 among among IN cord-026384-ejk9wjr1 209 27 preterm preterm JJ cord-026384-ejk9wjr1 209 28 infants infant NNS cord-026384-ejk9wjr1 209 29 . . . cord-026384-ejk9wjr1 210 1 Model model NN cord-026384-ejk9wjr1 210 2 evaluation evaluation NN cord-026384-ejk9wjr1 210 3 . . . cord-026384-ejk9wjr1 211 1 Waljee Waljee NNP cord-026384-ejk9wjr1 211 2 et et NNP cord-026384-ejk9wjr1 211 3 al al NNP cord-026384-ejk9wjr1 211 4 . . . cord-026384-ejk9wjr1 212 1 18 18 CD cord-026384-ejk9wjr1 212 2 provide provide VBP cord-026384-ejk9wjr1 212 3 a a DT cord-026384-ejk9wjr1 212 4 summary summary NN cord-026384-ejk9wjr1 212 5 of of IN cord-026384-ejk9wjr1 212 6 methods method NNS cord-026384-ejk9wjr1 212 7 for for IN cord-026384-ejk9wjr1 212 8 assessing assess VBG cord-026384-ejk9wjr1 212 9 the the DT cord-026384-ejk9wjr1 212 10 performance performance NN cord-026384-ejk9wjr1 212 11 of of IN cord-026384-ejk9wjr1 212 12 a a DT cord-026384-ejk9wjr1 212 13 predictive predictive JJ cord-026384-ejk9wjr1 212 14 model model NN cord-026384-ejk9wjr1 212 15 , , , cord-026384-ejk9wjr1 212 16 categorizing categorize VBG cord-026384-ejk9wjr1 212 17 them -PRON- PRP cord-026384-ejk9wjr1 212 18 into into IN cord-026384-ejk9wjr1 212 19 three three CD cord-026384-ejk9wjr1 212 20 types type NNS cord-026384-ejk9wjr1 212 21 : : : cord-026384-ejk9wjr1 212 22 overall overall JJ cord-026384-ejk9wjr1 212 23 model model NN cord-026384-ejk9wjr1 212 24 performance performance NN cord-026384-ejk9wjr1 212 25 , , , cord-026384-ejk9wjr1 212 26 which which WDT cord-026384-ejk9wjr1 212 27 focuses focus VBZ cord-026384-ejk9wjr1 212 28 on on IN cord-026384-ejk9wjr1 212 29 the the DT cord-026384-ejk9wjr1 212 30 extent extent NN cord-026384-ejk9wjr1 212 31 of of IN cord-026384-ejk9wjr1 212 32 variation variation NN cord-026384-ejk9wjr1 212 33 in in IN cord-026384-ejk9wjr1 212 34 risk risk NN cord-026384-ejk9wjr1 212 35 explained explain VBN cord-026384-ejk9wjr1 212 36 by by IN cord-026384-ejk9wjr1 212 37 the the DT cord-026384-ejk9wjr1 212 38 model model NN cord-026384-ejk9wjr1 212 39 ; ; : cord-026384-ejk9wjr1 212 40 calibration calibration NN cord-026384-ejk9wjr1 212 41 , , , cord-026384-ejk9wjr1 212 42 which which WDT cord-026384-ejk9wjr1 212 43 assesses assess VBZ cord-026384-ejk9wjr1 212 44 differences difference NNS cord-026384-ejk9wjr1 212 45 between between IN cord-026384-ejk9wjr1 212 46 observed observed JJ cord-026384-ejk9wjr1 212 47 and and CC cord-026384-ejk9wjr1 212 48 predicted predict VBD cord-026384-ejk9wjr1 212 49 event event NN cord-026384-ejk9wjr1 212 50 rates rate NNS cord-026384-ejk9wjr1 212 51 ; ; : cord-026384-ejk9wjr1 212 52 and and CC cord-026384-ejk9wjr1 212 53 discrimination discrimination NN cord-026384-ejk9wjr1 212 54 , , , cord-026384-ejk9wjr1 212 55 which which WDT cord-026384-ejk9wjr1 212 56 assesses assess VBZ cord-026384-ejk9wjr1 212 57 the the DT cord-026384-ejk9wjr1 212 58 ability ability NN cord-026384-ejk9wjr1 212 59 to to TO cord-026384-ejk9wjr1 212 60 distinguish distinguish VB cord-026384-ejk9wjr1 212 61 between between IN cord-026384-ejk9wjr1 212 62 patients patient NNS cord-026384-ejk9wjr1 212 63 who who WP cord-026384-ejk9wjr1 212 64 do do VBP cord-026384-ejk9wjr1 212 65 and and CC cord-026384-ejk9wjr1 212 66 do do VBP cord-026384-ejk9wjr1 212 67 not not RB cord-026384-ejk9wjr1 212 68 experience experience VB cord-026384-ejk9wjr1 212 69 the the DT cord-026384-ejk9wjr1 212 70 outcome outcome NN cord-026384-ejk9wjr1 212 71 of of IN cord-026384-ejk9wjr1 212 72 interest interest NN cord-026384-ejk9wjr1 212 73 . . . cord-026384-ejk9wjr1 213 1 The the DT cord-026384-ejk9wjr1 213 2 majority majority NN cord-026384-ejk9wjr1 213 3 of of IN cord-026384-ejk9wjr1 213 4 studies study NNS cord-026384-ejk9wjr1 213 5 in in IN cord-026384-ejk9wjr1 213 6 our -PRON- PRP$ cord-026384-ejk9wjr1 213 7 review review NN cord-026384-ejk9wjr1 213 8 assessed assess VBD cord-026384-ejk9wjr1 213 9 their -PRON- PRP$ cord-026384-ejk9wjr1 213 10 models model NNS cord-026384-ejk9wjr1 213 11 with with IN cord-026384-ejk9wjr1 213 12 ROC ROC NNP cord-026384-ejk9wjr1 213 13 curve curve NN cord-026384-ejk9wjr1 213 14 analysis analysis NN cord-026384-ejk9wjr1 213 15 , , , cord-026384-ejk9wjr1 213 16 a a DT cord-026384-ejk9wjr1 213 17 method method NN cord-026384-ejk9wjr1 213 18 of of IN cord-026384-ejk9wjr1 213 19 assessing assess VBG cord-026384-ejk9wjr1 213 20 discrimination discrimination NN cord-026384-ejk9wjr1 213 21 . . . cord-026384-ejk9wjr1 214 1 While while IN cord-026384-ejk9wjr1 214 2 widely widely RB cord-026384-ejk9wjr1 214 3 used use VBN cord-026384-ejk9wjr1 214 4 , , , cord-026384-ejk9wjr1 214 5 there there EX cord-026384-ejk9wjr1 214 6 is be VBZ cord-026384-ejk9wjr1 214 7 some some DT cord-026384-ejk9wjr1 214 8 debate debate NN cord-026384-ejk9wjr1 214 9 with with IN cord-026384-ejk9wjr1 214 10 regard regard NN cord-026384-ejk9wjr1 214 11 to to IN cord-026384-ejk9wjr1 214 12 ROC ROC NNP cord-026384-ejk9wjr1 214 13 - - HYPH cord-026384-ejk9wjr1 214 14 based base VBN cord-026384-ejk9wjr1 214 15 assessments assessment NNS cord-026384-ejk9wjr1 214 16 , , , cord-026384-ejk9wjr1 214 17 specifically specifically RB cord-026384-ejk9wjr1 214 18 in in IN cord-026384-ejk9wjr1 214 19 regard regard NN cord-026384-ejk9wjr1 214 20 to to IN cord-026384-ejk9wjr1 214 21 its -PRON- PRP$ cord-026384-ejk9wjr1 214 22 lack lack NN cord-026384-ejk9wjr1 214 23 of of IN cord-026384-ejk9wjr1 214 24 sensitivity sensitivity NN cord-026384-ejk9wjr1 214 25 in in IN cord-026384-ejk9wjr1 214 26 assessing assess VBG cord-026384-ejk9wjr1 214 27 differences difference NNS cord-026384-ejk9wjr1 214 28 between between IN cord-026384-ejk9wjr1 214 29 good good JJ cord-026384-ejk9wjr1 214 30 predictive predictive JJ cord-026384-ejk9wjr1 214 31 models model NNS cord-026384-ejk9wjr1 214 32 . . . cord-026384-ejk9wjr1 215 1 96 96 CD cord-026384-ejk9wjr1 216 1 Although although IN cord-026384-ejk9wjr1 216 2 several several JJ cord-026384-ejk9wjr1 216 3 novel novel JJ cord-026384-ejk9wjr1 216 4 performance performance NN cord-026384-ejk9wjr1 216 5 measures measure NNS cord-026384-ejk9wjr1 216 6 for for IN cord-026384-ejk9wjr1 216 7 comparing compare VBG cord-026384-ejk9wjr1 216 8 discrimination discrimination NN cord-026384-ejk9wjr1 216 9 among among IN cord-026384-ejk9wjr1 216 10 models model NNS cord-026384-ejk9wjr1 216 11 have have VBP cord-026384-ejk9wjr1 216 12 been be VBN cord-026384-ejk9wjr1 216 13 proposed propose VBN cord-026384-ejk9wjr1 216 14 , , , cord-026384-ejk9wjr1 216 15 none none NN cord-026384-ejk9wjr1 216 16 have have VBP cord-026384-ejk9wjr1 216 17 been be VBN cord-026384-ejk9wjr1 216 18 employed employ VBN cord-026384-ejk9wjr1 216 19 in in IN cord-026384-ejk9wjr1 216 20 the the DT cord-026384-ejk9wjr1 216 21 context context NN cord-026384-ejk9wjr1 216 22 of of IN cord-026384-ejk9wjr1 216 23 comparing compare VBG cord-026384-ejk9wjr1 216 24 risk risk NN cord-026384-ejk9wjr1 216 25 prediction prediction NN cord-026384-ejk9wjr1 216 26 tools tool NNS cord-026384-ejk9wjr1 216 27 for for IN cord-026384-ejk9wjr1 216 28 preterm preterm JJ cord-026384-ejk9wjr1 216 29 neonates neonate NNS cord-026384-ejk9wjr1 216 30 . . . cord-026384-ejk9wjr1 217 1 97 97 CD cord-026384-ejk9wjr1 217 2 , , , cord-026384-ejk9wjr1 217 3 98 98 CD cord-026384-ejk9wjr1 217 4 Few few JJ cord-026384-ejk9wjr1 217 5 studies study NNS cord-026384-ejk9wjr1 217 6 employed employ VBD cord-026384-ejk9wjr1 217 7 analyses analysis NNS cord-026384-ejk9wjr1 217 8 other other JJ cord-026384-ejk9wjr1 217 9 than than IN cord-026384-ejk9wjr1 217 10 ROC ROC NNP cord-026384-ejk9wjr1 217 11 . . . cord-026384-ejk9wjr1 218 1 Only only RB cord-026384-ejk9wjr1 218 2 six six CD cord-026384-ejk9wjr1 218 3 in in IN cord-026384-ejk9wjr1 218 4 our -PRON- PRP$ cord-026384-ejk9wjr1 218 5 review review NN cord-026384-ejk9wjr1 218 6 assessed assess VBD cord-026384-ejk9wjr1 218 7 overall overall JJ cord-026384-ejk9wjr1 218 8 performance performance NN cord-026384-ejk9wjr1 218 9 with with IN cord-026384-ejk9wjr1 218 10 R R NNP cord-026384-ejk9wjr1 218 11 2 2 CD cord-026384-ejk9wjr1 218 12 or or CC cord-026384-ejk9wjr1 218 13 partial partial JJ cord-026384-ejk9wjr1 218 14 R r NN cord-026384-ejk9wjr1 218 15 2 2 CD cord-026384-ejk9wjr1 218 16 , , , cord-026384-ejk9wjr1 218 17 and and CC cord-026384-ejk9wjr1 218 18 five five CD cord-026384-ejk9wjr1 218 19 evaluated evaluate VBN cord-026384-ejk9wjr1 218 20 calibration calibration NN cord-026384-ejk9wjr1 218 21 using use VBG cord-026384-ejk9wjr1 218 22 the the DT cord-026384-ejk9wjr1 218 23 Hosmer Hosmer NNP cord-026384-ejk9wjr1 218 24 - - HYPH cord-026384-ejk9wjr1 218 25 Lemeshow Lemeshow NNP cord-026384-ejk9wjr1 218 26 test test NN cord-026384-ejk9wjr1 218 27 . . . cord-026384-ejk9wjr1 219 1 Another another DT cord-026384-ejk9wjr1 219 2 four four CD cord-026384-ejk9wjr1 219 3 studies study NNS cord-026384-ejk9wjr1 219 4 assessed assess VBD cord-026384-ejk9wjr1 219 5 internal internal JJ cord-026384-ejk9wjr1 219 6 validation validation NN cord-026384-ejk9wjr1 219 7 with with IN cord-026384-ejk9wjr1 219 8 either either CC cord-026384-ejk9wjr1 219 9 an an DT cord-026384-ejk9wjr1 219 10 internal internal JJ cord-026384-ejk9wjr1 219 11 validation validation NN cord-026384-ejk9wjr1 219 12 set set VBN cord-026384-ejk9wjr1 219 13 or or CC cord-026384-ejk9wjr1 219 14 bootstrapping bootstrappe VBG cord-026384-ejk9wjr1 219 15 techniques technique NNS cord-026384-ejk9wjr1 219 16 . . . cord-026384-ejk9wjr1 220 1 99 99 CD cord-026384-ejk9wjr1 221 1 There there EX cord-026384-ejk9wjr1 221 2 were be VBD cord-026384-ejk9wjr1 221 3 nine nine CD cord-026384-ejk9wjr1 221 4 studies study NNS cord-026384-ejk9wjr1 221 5 meeting meeting NN cord-026384-ejk9wjr1 221 6 inclusion inclusion NN cord-026384-ejk9wjr1 221 7 criteria criterion NNS cord-026384-ejk9wjr1 221 8 solely solely RB cord-026384-ejk9wjr1 221 9 because because IN cord-026384-ejk9wjr1 221 10 they -PRON- PRP cord-026384-ejk9wjr1 221 11 had have VBD cord-026384-ejk9wjr1 221 12 models model NNS cord-026384-ejk9wjr1 221 13 that that WDT cord-026384-ejk9wjr1 221 14 were be VBD cord-026384-ejk9wjr1 221 15 externally externally RB cord-026384-ejk9wjr1 221 16 validated validate VBN cord-026384-ejk9wjr1 221 17 via via IN cord-026384-ejk9wjr1 221 18 other other JJ cord-026384-ejk9wjr1 221 19 studies study NNS cord-026384-ejk9wjr1 221 20 . . . cord-026384-ejk9wjr1 222 1 Schmidt Schmidt NNP cord-026384-ejk9wjr1 222 2 et et NNP cord-026384-ejk9wjr1 222 3 al al NNP cord-026384-ejk9wjr1 222 4 . . . cord-026384-ejk9wjr1 223 1 32 32 CD cord-026384-ejk9wjr1 223 2 reported report VBD cord-026384-ejk9wjr1 223 3 odds odd NNS cord-026384-ejk9wjr1 223 4 ratio ratio NN cord-026384-ejk9wjr1 223 5 associations association NNS cord-026384-ejk9wjr1 223 6 for for IN cord-026384-ejk9wjr1 223 7 their -PRON- PRP$ cord-026384-ejk9wjr1 223 8 3-morbidity 3-morbidity CD cord-026384-ejk9wjr1 223 9 model model NN cord-026384-ejk9wjr1 223 10 , , , cord-026384-ejk9wjr1 223 11 which which WDT cord-026384-ejk9wjr1 223 12 are be VBP cord-026384-ejk9wjr1 223 13 not not RB cord-026384-ejk9wjr1 223 14 a a DT cord-026384-ejk9wjr1 223 15 reliable reliable JJ cord-026384-ejk9wjr1 223 16 method method NN cord-026384-ejk9wjr1 223 17 of of IN cord-026384-ejk9wjr1 223 18 determining determine VBG cord-026384-ejk9wjr1 223 19 the the DT cord-026384-ejk9wjr1 223 20 strength strength NN cord-026384-ejk9wjr1 223 21 of of IN cord-026384-ejk9wjr1 223 22 risk risk NN cord-026384-ejk9wjr1 223 23 prediction prediction NN cord-026384-ejk9wjr1 223 24 tools tool NNS cord-026384-ejk9wjr1 223 25 . . . cord-026384-ejk9wjr1 224 1 100 100 CD cord-026384-ejk9wjr1 224 2 Future future JJ cord-026384-ejk9wjr1 224 3 risk risk NN cord-026384-ejk9wjr1 224 4 model model NN cord-026384-ejk9wjr1 224 5 assessments assessment NNS cord-026384-ejk9wjr1 224 6 for for IN cord-026384-ejk9wjr1 224 7 preterm preterm JJ cord-026384-ejk9wjr1 224 8 neonates neonate NNS cord-026384-ejk9wjr1 224 9 should should MD cord-026384-ejk9wjr1 224 10 at at IN cord-026384-ejk9wjr1 224 11 minimum minimum NN cord-026384-ejk9wjr1 224 12 include include VB cord-026384-ejk9wjr1 224 13 an an DT cord-026384-ejk9wjr1 224 14 ROC ROC NNP cord-026384-ejk9wjr1 224 15 curve curve NN cord-026384-ejk9wjr1 224 16 analysis analysis NN cord-026384-ejk9wjr1 224 17 , , , cord-026384-ejk9wjr1 224 18 although although IN cord-026384-ejk9wjr1 224 19 assessments assessment NNS cord-026384-ejk9wjr1 224 20 of of IN cord-026384-ejk9wjr1 224 21 overall overall JJ cord-026384-ejk9wjr1 224 22 performance performance NN cord-026384-ejk9wjr1 224 23 and and CC cord-026384-ejk9wjr1 224 24 calibration calibration NN cord-026384-ejk9wjr1 224 25 would would MD cord-026384-ejk9wjr1 224 26 also also RB cord-026384-ejk9wjr1 224 27 be be VB cord-026384-ejk9wjr1 224 28 helpful helpful JJ cord-026384-ejk9wjr1 224 29 . . . cord-026384-ejk9wjr1 225 1 Validation validation NN cord-026384-ejk9wjr1 225 2 with with IN cord-026384-ejk9wjr1 225 3 a a DT cord-026384-ejk9wjr1 225 4 different different JJ cord-026384-ejk9wjr1 225 5 sample sample NN cord-026384-ejk9wjr1 225 6 from from IN cord-026384-ejk9wjr1 225 7 the the DT cord-026384-ejk9wjr1 225 8 development development NN cord-026384-ejk9wjr1 225 9 set set NN cord-026384-ejk9wjr1 225 10 is be VBZ cord-026384-ejk9wjr1 225 11 also also RB cord-026384-ejk9wjr1 225 12 advised advise VBN cord-026384-ejk9wjr1 225 13 , , , cord-026384-ejk9wjr1 225 14 ideally ideally RB cord-026384-ejk9wjr1 225 15 with with IN cord-026384-ejk9wjr1 225 16 a a DT cord-026384-ejk9wjr1 225 17 population population NN cord-026384-ejk9wjr1 225 18 outside outside IN cord-026384-ejk9wjr1 225 19 the the DT cord-026384-ejk9wjr1 225 20 original original JJ cord-026384-ejk9wjr1 225 21 cohort cohort NN cord-026384-ejk9wjr1 225 22 . . . cord-026384-ejk9wjr1 226 1 18 18 CD cord-026384-ejk9wjr1 226 2 CONCLUSION CONCLUSION NNP cord-026384-ejk9wjr1 226 3 Risk Risk NNP cord-026384-ejk9wjr1 226 4 assessment assessment NN cord-026384-ejk9wjr1 226 5 and and CC cord-026384-ejk9wjr1 226 6 outcomes outcome NNS cord-026384-ejk9wjr1 226 7 prediction prediction NN cord-026384-ejk9wjr1 226 8 are be VBP cord-026384-ejk9wjr1 226 9 valuable valuable JJ cord-026384-ejk9wjr1 226 10 tools tool NNS cord-026384-ejk9wjr1 226 11 in in IN cord-026384-ejk9wjr1 226 12 medical medical JJ cord-026384-ejk9wjr1 226 13 decision decision NN cord-026384-ejk9wjr1 226 14 - - HYPH cord-026384-ejk9wjr1 226 15 making making NN cord-026384-ejk9wjr1 226 16 . . . cord-026384-ejk9wjr1 227 1 Fortunately fortunately RB cord-026384-ejk9wjr1 227 2 , , , cord-026384-ejk9wjr1 227 3 infants infant NNS cord-026384-ejk9wjr1 227 4 born bear VBN cord-026384-ejk9wjr1 227 5 prematurely prematurely RB cord-026384-ejk9wjr1 227 6 enjoy enjoy VBP cord-026384-ejk9wjr1 227 7 ever ever RB cord-026384-ejk9wjr1 227 8 - - HYPH cord-026384-ejk9wjr1 227 9 increasing increase VBG cord-026384-ejk9wjr1 227 10 likelihood likelihood NN cord-026384-ejk9wjr1 227 11 of of IN cord-026384-ejk9wjr1 227 12 survival survival NN cord-026384-ejk9wjr1 227 13 . . . cord-026384-ejk9wjr1 228 1 Research research NN cord-026384-ejk9wjr1 228 2 over over IN cord-026384-ejk9wjr1 228 3 the the DT cord-026384-ejk9wjr1 228 4 past past JJ cord-026384-ejk9wjr1 228 5 several several JJ cord-026384-ejk9wjr1 228 6 decades decade NNS cord-026384-ejk9wjr1 228 7 has have VBZ cord-026384-ejk9wjr1 228 8 highlighted highlight VBN cord-026384-ejk9wjr1 228 9 the the DT cord-026384-ejk9wjr1 228 10 many many JJ cord-026384-ejk9wjr1 228 11 influences influence NNS cord-026384-ejk9wjr1 228 12 , , , cord-026384-ejk9wjr1 228 13 physiologic physiologic JJ cord-026384-ejk9wjr1 228 14 and and CC cord-026384-ejk9wjr1 228 15 psychosocial psychosocial JJ cord-026384-ejk9wjr1 228 16 , , , cord-026384-ejk9wjr1 228 17 affecting affect VBG cord-026384-ejk9wjr1 228 18 neurodevelopment neurodevelopment NN cord-026384-ejk9wjr1 228 19 , , , cord-026384-ejk9wjr1 228 20 HRQL HRQL NNP cord-026384-ejk9wjr1 228 21 , , , cord-026384-ejk9wjr1 228 22 and and CC cord-026384-ejk9wjr1 228 23 health health NN cord-026384-ejk9wjr1 228 24 services service NNS cord-026384-ejk9wjr1 228 25 utilization utilization NN cord-026384-ejk9wjr1 228 26 . . . cord-026384-ejk9wjr1 229 1 Yet yet RB cord-026384-ejk9wjr1 229 2 , , , cord-026384-ejk9wjr1 229 3 the the DT cord-026384-ejk9wjr1 229 4 wealth wealth NN cord-026384-ejk9wjr1 229 5 of of IN cord-026384-ejk9wjr1 229 6 knowledge knowledge NN cord-026384-ejk9wjr1 229 7 gained gain VBN cord-026384-ejk9wjr1 229 8 from from IN cord-026384-ejk9wjr1 229 9 longitudinal longitudinal JJ cord-026384-ejk9wjr1 229 10 studies study NNS cord-026384-ejk9wjr1 229 11 of of IN cord-026384-ejk9wjr1 229 12 growth growth NN cord-026384-ejk9wjr1 229 13 and and CC cord-026384-ejk9wjr1 229 14 development development NN cord-026384-ejk9wjr1 229 15 is be VBZ cord-026384-ejk9wjr1 229 16 not not RB cord-026384-ejk9wjr1 229 17 reflected reflect VBN cord-026384-ejk9wjr1 229 18 in in IN cord-026384-ejk9wjr1 229 19 current current JJ cord-026384-ejk9wjr1 229 20 risk risk NN cord-026384-ejk9wjr1 229 21 prediction prediction NN cord-026384-ejk9wjr1 229 22 models model NNS cord-026384-ejk9wjr1 229 23 . . . cord-026384-ejk9wjr1 230 1 Moreover moreover RB cord-026384-ejk9wjr1 230 2 , , , cord-026384-ejk9wjr1 230 3 some some DT cord-026384-ejk9wjr1 230 4 of of IN cord-026384-ejk9wjr1 230 5 the the DT cord-026384-ejk9wjr1 230 6 most most RBS cord-026384-ejk9wjr1 230 7 wellknown wellknown JJ cord-026384-ejk9wjr1 230 8 and and CC cord-026384-ejk9wjr1 230 9 widely widely RB cord-026384-ejk9wjr1 230 10 used use VBN cord-026384-ejk9wjr1 230 11 tools tool NNS cord-026384-ejk9wjr1 230 12 today today NN cord-026384-ejk9wjr1 230 13 , , , cord-026384-ejk9wjr1 230 14 such such JJ cord-026384-ejk9wjr1 230 15 as as IN cord-026384-ejk9wjr1 230 16 Tyson Tyson NNP cord-026384-ejk9wjr1 230 17 et et NNP cord-026384-ejk9wjr1 230 18 al al NNP cord-026384-ejk9wjr1 230 19 . . NNP cord-026384-ejk9wjr1 230 20 's 's POS cord-026384-ejk9wjr1 230 21 13 13 CD cord-026384-ejk9wjr1 230 22 fivefactor fivefactor NN cord-026384-ejk9wjr1 230 23 model model NN cord-026384-ejk9wjr1 230 24 , , , cord-026384-ejk9wjr1 230 25 were be VBD cord-026384-ejk9wjr1 230 26 developed develop VBN cord-026384-ejk9wjr1 230 27 nearly nearly RB cord-026384-ejk9wjr1 230 28 two two CD cord-026384-ejk9wjr1 230 29 decades decade NNS cord-026384-ejk9wjr1 230 30 ago ago RB cord-026384-ejk9wjr1 230 31 . . . cord-026384-ejk9wjr1 231 1 As as IN cord-026384-ejk9wjr1 231 2 advances advance NNS cord-026384-ejk9wjr1 231 3 in in IN cord-026384-ejk9wjr1 231 4 neonatal neonatal JJ cord-026384-ejk9wjr1 231 5 intensive intensive JJ cord-026384-ejk9wjr1 231 6 care care NN cord-026384-ejk9wjr1 231 7 progressively progressively RB cord-026384-ejk9wjr1 231 8 reduce reduce VBP cord-026384-ejk9wjr1 231 9 the the DT cord-026384-ejk9wjr1 231 10 risk risk NN cord-026384-ejk9wjr1 231 11 of of IN cord-026384-ejk9wjr1 231 12 certain certain JJ cord-026384-ejk9wjr1 231 13 outcomes outcome NNS cord-026384-ejk9wjr1 231 14 , , , cord-026384-ejk9wjr1 231 15 it -PRON- PRP cord-026384-ejk9wjr1 231 16 is be VBZ cord-026384-ejk9wjr1 231 17 clear clear JJ cord-026384-ejk9wjr1 231 18 that that IN cord-026384-ejk9wjr1 231 19 these these DT cord-026384-ejk9wjr1 231 20 older old JJR cord-026384-ejk9wjr1 231 21 models model NNS cord-026384-ejk9wjr1 231 22 require require VBP cord-026384-ejk9wjr1 231 23 updating update VBG cord-026384-ejk9wjr1 231 24 if if IN cord-026384-ejk9wjr1 231 25 they -PRON- PRP cord-026384-ejk9wjr1 231 26 are be VBP cord-026384-ejk9wjr1 231 27 to to TO cord-026384-ejk9wjr1 231 28 be be VB cord-026384-ejk9wjr1 231 29 of of IN cord-026384-ejk9wjr1 231 30 continued continue VBN cord-026384-ejk9wjr1 231 31 clinical clinical JJ cord-026384-ejk9wjr1 231 32 use use NN cord-026384-ejk9wjr1 231 33 . . . cord-026384-ejk9wjr1 232 1 It -PRON- PRP cord-026384-ejk9wjr1 232 2 should should MD cord-026384-ejk9wjr1 232 3 be be VB cord-026384-ejk9wjr1 232 4 recognized recognize VBN cord-026384-ejk9wjr1 232 5 that that IN cord-026384-ejk9wjr1 232 6 there there EX cord-026384-ejk9wjr1 232 7 are be VBP cord-026384-ejk9wjr1 232 8 potential potential JJ cord-026384-ejk9wjr1 232 9 ethical ethical JJ cord-026384-ejk9wjr1 232 10 ramifications ramification NNS cord-026384-ejk9wjr1 232 11 to to IN cord-026384-ejk9wjr1 232 12 incorporating incorporate VBG cord-026384-ejk9wjr1 232 13 more more JJR cord-026384-ejk9wjr1 232 14 psychosocial psychosocial JJ cord-026384-ejk9wjr1 232 15 factors factor NNS cord-026384-ejk9wjr1 232 16 and and CC cord-026384-ejk9wjr1 232 17 outcomes outcome NNS cord-026384-ejk9wjr1 232 18 into into IN cord-026384-ejk9wjr1 232 19 risk risk NN cord-026384-ejk9wjr1 232 20 prediction prediction NN cord-026384-ejk9wjr1 232 21 models model NNS cord-026384-ejk9wjr1 232 22 , , , cord-026384-ejk9wjr1 232 23 such such JJ cord-026384-ejk9wjr1 232 24 as as IN cord-026384-ejk9wjr1 232 25 crossing cross VBG cord-026384-ejk9wjr1 232 26 the the DT cord-026384-ejk9wjr1 232 27 line line NN cord-026384-ejk9wjr1 232 28 from from IN cord-026384-ejk9wjr1 232 29 risk risk NN cord-026384-ejk9wjr1 232 30 stratification stratification NN cord-026384-ejk9wjr1 232 31 to to IN cord-026384-ejk9wjr1 232 32 " " `` cord-026384-ejk9wjr1 232 33 profiling profile VBG cord-026384-ejk9wjr1 232 34 " " '' cord-026384-ejk9wjr1 232 35 patients patient NNS cord-026384-ejk9wjr1 232 36 and and CC cord-026384-ejk9wjr1 232 37 offering offer VBG cord-026384-ejk9wjr1 232 38 different different JJ cord-026384-ejk9wjr1 232 39 treatment treatment NN cord-026384-ejk9wjr1 232 40 decisions decision NNS cord-026384-ejk9wjr1 232 41 based base VBN cord-026384-ejk9wjr1 232 42 on on IN cord-026384-ejk9wjr1 232 43 race race NN cord-026384-ejk9wjr1 232 44 or or CC cord-026384-ejk9wjr1 232 45 class class NN cord-026384-ejk9wjr1 232 46 . . . cord-026384-ejk9wjr1 233 1 101 101 CD cord-026384-ejk9wjr1 234 1 However however RB cord-026384-ejk9wjr1 234 2 , , , cord-026384-ejk9wjr1 234 3 physician physician NN cord-026384-ejk9wjr1 234 4 predictions prediction NNS cord-026384-ejk9wjr1 234 5 without without IN cord-026384-ejk9wjr1 234 6 the the DT cord-026384-ejk9wjr1 234 7 aid aid NN cord-026384-ejk9wjr1 234 8 of of IN cord-026384-ejk9wjr1 234 9 prediction prediction NN cord-026384-ejk9wjr1 234 10 tools tool NNS cord-026384-ejk9wjr1 234 11 are be VBP cord-026384-ejk9wjr1 234 12 highly highly RB cord-026384-ejk9wjr1 234 13 inconsistent inconsistent JJ cord-026384-ejk9wjr1 234 14 during during IN cord-026384-ejk9wjr1 234 15 counseling counseling NN cord-026384-ejk9wjr1 234 16 at at IN cord-026384-ejk9wjr1 234 17 the the DT cord-026384-ejk9wjr1 234 18 margins margin NNS cord-026384-ejk9wjr1 234 19 of of IN cord-026384-ejk9wjr1 234 20 viability viability NN cord-026384-ejk9wjr1 234 21 , , , cord-026384-ejk9wjr1 234 22 and and CC cord-026384-ejk9wjr1 234 23 further further JJ cord-026384-ejk9wjr1 234 24 research research NN cord-026384-ejk9wjr1 234 25 is be VBZ cord-026384-ejk9wjr1 234 26 needed need VBN cord-026384-ejk9wjr1 234 27 regarding regard VBG cord-026384-ejk9wjr1 234 28 the the DT cord-026384-ejk9wjr1 234 29 level level NN cord-026384-ejk9wjr1 234 30 of of IN cord-026384-ejk9wjr1 234 31 influence influence NN cord-026384-ejk9wjr1 234 32 that that WDT cord-026384-ejk9wjr1 234 33 physicians physician NNS cord-026384-ejk9wjr1 234 34 actually actually RB cord-026384-ejk9wjr1 234 35 have have VBP cord-026384-ejk9wjr1 234 36 on on IN cord-026384-ejk9wjr1 234 37 caregiver caregiver NN cord-026384-ejk9wjr1 234 38 decision decision NN cord-026384-ejk9wjr1 234 39 - - HYPH cord-026384-ejk9wjr1 234 40 making making NN cord-026384-ejk9wjr1 234 41 during during IN cord-026384-ejk9wjr1 234 42 counseling counseling NN cord-026384-ejk9wjr1 234 43 , , , cord-026384-ejk9wjr1 234 44 as as RB cord-026384-ejk9wjr1 234 45 well well RB cord-026384-ejk9wjr1 234 46 as as IN cord-026384-ejk9wjr1 234 47 the the DT cord-026384-ejk9wjr1 234 48 extent extent NN cord-026384-ejk9wjr1 234 49 to to TO cord-026384-ejk9wjr1 234 50 which which WDT cord-026384-ejk9wjr1 234 51 risk risk NN cord-026384-ejk9wjr1 234 52 prediction prediction NN cord-026384-ejk9wjr1 234 53 tools tool NNS cord-026384-ejk9wjr1 234 54 would would MD cord-026384-ejk9wjr1 234 55 change change VB cord-026384-ejk9wjr1 234 56 their -PRON- PRP$ cord-026384-ejk9wjr1 234 57 approach approach NN cord-026384-ejk9wjr1 234 58 to to IN cord-026384-ejk9wjr1 234 59 counseling counseling NN cord-026384-ejk9wjr1 234 60 . . . cord-026384-ejk9wjr1 235 1 10 10 CD cord-026384-ejk9wjr1 236 1 In in IN cord-026384-ejk9wjr1 236 2 addition addition NN cord-026384-ejk9wjr1 236 3 , , , cord-026384-ejk9wjr1 236 4 despite despite IN cord-026384-ejk9wjr1 236 5 recent recent JJ cord-026384-ejk9wjr1 236 6 innovation innovation NN cord-026384-ejk9wjr1 236 7 in in IN cord-026384-ejk9wjr1 236 8 statistical statistical JJ cord-026384-ejk9wjr1 236 9 approaches approach NNS cord-026384-ejk9wjr1 236 10 to to TO cord-026384-ejk9wjr1 236 11 risk risk VB cord-026384-ejk9wjr1 236 12 modeling modeling NN cord-026384-ejk9wjr1 236 13 , , , cord-026384-ejk9wjr1 236 14 such such JJ cord-026384-ejk9wjr1 236 15 as as IN cord-026384-ejk9wjr1 236 16 machine machine NN cord-026384-ejk9wjr1 236 17 learning learning NN cord-026384-ejk9wjr1 236 18 , , , cord-026384-ejk9wjr1 236 19 most most JJS cord-026384-ejk9wjr1 236 20 prediction prediction NN cord-026384-ejk9wjr1 236 21 tools tool NNS cord-026384-ejk9wjr1 236 22 rely rely VBP cord-026384-ejk9wjr1 236 23 on on IN cord-026384-ejk9wjr1 236 24 standard standard JJ cord-026384-ejk9wjr1 236 25 regression regression NN cord-026384-ejk9wjr1 236 26 techniques technique NNS cord-026384-ejk9wjr1 236 27 . . . cord-026384-ejk9wjr1 237 1 Insofar insofar RB cord-026384-ejk9wjr1 237 2 that that DT cord-026384-ejk9wjr1 237 3 risk risk VBP cord-026384-ejk9wjr1 237 4 prediction prediction NN cord-026384-ejk9wjr1 237 5 models model NNS cord-026384-ejk9wjr1 237 6 will will MD cord-026384-ejk9wjr1 237 7 continue continue VB cord-026384-ejk9wjr1 237 8 to to TO cord-026384-ejk9wjr1 237 9 be be VB cord-026384-ejk9wjr1 237 10 developed develop VBN cord-026384-ejk9wjr1 237 11 for for IN cord-026384-ejk9wjr1 237 12 preterm preterm JJ cord-026384-ejk9wjr1 237 13 neonatal neonatal JJ cord-026384-ejk9wjr1 237 14 care care NN cord-026384-ejk9wjr1 237 15 , , , cord-026384-ejk9wjr1 237 16 making make VBG cord-026384-ejk9wjr1 237 17 use use NN cord-026384-ejk9wjr1 237 18 of of IN cord-026384-ejk9wjr1 237 19 the the DT cord-026384-ejk9wjr1 237 20 clinical clinical JJ cord-026384-ejk9wjr1 237 21 data datum NNS cord-026384-ejk9wjr1 237 22 available available JJ cord-026384-ejk9wjr1 237 23 in in IN cord-026384-ejk9wjr1 237 24 most most JJS cord-026384-ejk9wjr1 237 25 modern modern JJ cord-026384-ejk9wjr1 237 26 electronic electronic JJ cord-026384-ejk9wjr1 237 27 health health NN cord-026384-ejk9wjr1 237 28 records record NNS cord-026384-ejk9wjr1 237 29 and and CC cord-026384-ejk9wjr1 237 30 taking take VBG cord-026384-ejk9wjr1 237 31 into into IN cord-026384-ejk9wjr1 237 32 consideration consideration NN cord-026384-ejk9wjr1 237 33 the the DT cord-026384-ejk9wjr1 237 34 analytic analytic JJ cord-026384-ejk9wjr1 237 35 challenges challenge NNS cord-026384-ejk9wjr1 237 36 related relate VBN cord-026384-ejk9wjr1 237 37 to to IN cord-026384-ejk9wjr1 237 38 unequal unequal JJ cord-026384-ejk9wjr1 237 39 prior prior JJ cord-026384-ejk9wjr1 237 40 probabilities probability NNS cord-026384-ejk9wjr1 237 41 of of IN cord-026384-ejk9wjr1 237 42 exposures exposure NNS cord-026384-ejk9wjr1 237 43 , , , cord-026384-ejk9wjr1 237 44 non non JJ cord-026384-ejk9wjr1 237 45 - - JJ cord-026384-ejk9wjr1 237 46 independence independence NN cord-026384-ejk9wjr1 237 47 of of IN cord-026384-ejk9wjr1 237 48 variables variable NNS cord-026384-ejk9wjr1 237 49 , , , cord-026384-ejk9wjr1 237 50 and and CC cord-026384-ejk9wjr1 237 51 semi semi RB cord-026384-ejk9wjr1 237 52 - - JJ cord-026384-ejk9wjr1 237 53 competing competing JJ cord-026384-ejk9wjr1 237 54 risk risk NN cord-026384-ejk9wjr1 237 55 can can MD cord-026384-ejk9wjr1 237 56 only only RB cord-026384-ejk9wjr1 237 57 strengthen strengthen VB cord-026384-ejk9wjr1 237 58 our -PRON- PRP$ cord-026384-ejk9wjr1 237 59 approach approach NN cord-026384-ejk9wjr1 237 60 to to IN cord-026384-ejk9wjr1 237 61 predicting predict VBG cord-026384-ejk9wjr1 237 62 outcomes outcome NNS cord-026384-ejk9wjr1 237 63 . . . cord-026384-ejk9wjr1 238 1 We -PRON- PRP cord-026384-ejk9wjr1 238 2 therefore therefore RB cord-026384-ejk9wjr1 238 3 recommend recommend VBP cord-026384-ejk9wjr1 238 4 taking take VBG cord-026384-ejk9wjr1 238 5 a a DT cord-026384-ejk9wjr1 238 6 broader broad JJR cord-026384-ejk9wjr1 238 7 view view NN cord-026384-ejk9wjr1 238 8 of of IN cord-026384-ejk9wjr1 238 9 risk risk NN cord-026384-ejk9wjr1 238 10 , , , cord-026384-ejk9wjr1 238 11 incorporating incorporate VBG cord-026384-ejk9wjr1 238 12 these these DT cord-026384-ejk9wjr1 238 13 concepts concept NNS cord-026384-ejk9wjr1 238 14 in in IN cord-026384-ejk9wjr1 238 15 creating create VBG cord-026384-ejk9wjr1 238 16 stronger strong JJR cord-026384-ejk9wjr1 238 17 risk risk NN cord-026384-ejk9wjr1 238 18 prediction prediction NN cord-026384-ejk9wjr1 238 19 tools tool NNS cord-026384-ejk9wjr1 238 20 that that WDT cord-026384-ejk9wjr1 238 21 can can MD cord-026384-ejk9wjr1 238 22 ultimately ultimately RB cord-026384-ejk9wjr1 238 23 serve serve VB cord-026384-ejk9wjr1 238 24 to to TO cord-026384-ejk9wjr1 238 25 benefit benefit VB cord-026384-ejk9wjr1 238 26 the the DT cord-026384-ejk9wjr1 238 27 long long JJ cord-026384-ejk9wjr1 238 28 - - HYPH cord-026384-ejk9wjr1 238 29 term term NN cord-026384-ejk9wjr1 238 30 care care NN cord-026384-ejk9wjr1 238 31 of of IN cord-026384-ejk9wjr1 238 32 preterm preterm JJ cord-026384-ejk9wjr1 238 33 neonates neonate NNS cord-026384-ejk9wjr1 238 34 . . . cord-026384-ejk9wjr1 239 1 C.J.C. C.J.C. NNP cord-026384-ejk9wjr1 239 2 and and CC cord-026384-ejk9wjr1 239 3 J.S.L. J.S.L. NNP cord-026384-ejk9wjr1 239 4 designed design VBD cord-026384-ejk9wjr1 239 5 and and CC cord-026384-ejk9wjr1 239 6 carried carry VBD cord-026384-ejk9wjr1 239 7 out out RP cord-026384-ejk9wjr1 239 8 this this DT cord-026384-ejk9wjr1 239 9 literature literature NN cord-026384-ejk9wjr1 239 10 review review NN cord-026384-ejk9wjr1 239 11 . . . cord-026384-ejk9wjr1 240 1 C.J.C. C.J.C. NNP cord-026384-ejk9wjr1 240 2 , , , cord-026384-ejk9wjr1 240 3 J.S.L. J.S.L. NNP cord-026384-ejk9wjr1 240 4 , , , cord-026384-ejk9wjr1 240 5 and and CC cord-026384-ejk9wjr1 240 6 S.H. S.H. NNP cord-026384-ejk9wjr1 240 7 worked work VBD cord-026384-ejk9wjr1 240 8 jointly jointly RB cord-026384-ejk9wjr1 240 9 in in IN cord-026384-ejk9wjr1 240 10 the the DT cord-026384-ejk9wjr1 240 11 analysis analysis NN cord-026384-ejk9wjr1 240 12 and and CC cord-026384-ejk9wjr1 240 13 interpretation interpretation NN cord-026384-ejk9wjr1 240 14 of of IN cord-026384-ejk9wjr1 240 15 the the DT cord-026384-ejk9wjr1 240 16 literature literature NN cord-026384-ejk9wjr1 240 17 review review NN cord-026384-ejk9wjr1 240 18 results result NNS cord-026384-ejk9wjr1 240 19 , , , cord-026384-ejk9wjr1 240 20 as as RB cord-026384-ejk9wjr1 240 21 well well RB cord-026384-ejk9wjr1 240 22 as as IN cord-026384-ejk9wjr1 240 23 the the DT cord-026384-ejk9wjr1 240 24 drafting drafting NN cord-026384-ejk9wjr1 240 25 and and CC cord-026384-ejk9wjr1 240 26 revision revision NN cord-026384-ejk9wjr1 240 27 of of IN cord-026384-ejk9wjr1 240 28 this this DT cord-026384-ejk9wjr1 240 29 article article NN cord-026384-ejk9wjr1 240 30 . . . cord-026384-ejk9wjr1 241 1 All all DT cord-026384-ejk9wjr1 241 2 three three CD cord-026384-ejk9wjr1 241 3 authors author NNS cord-026384-ejk9wjr1 241 4 gave give VBD cord-026384-ejk9wjr1 241 5 final final JJ cord-026384-ejk9wjr1 241 6 approval approval NN cord-026384-ejk9wjr1 241 7 of of IN cord-026384-ejk9wjr1 241 8 the the DT cord-026384-ejk9wjr1 241 9 version version NN cord-026384-ejk9wjr1 241 10 to to TO cord-026384-ejk9wjr1 241 11 be be VB cord-026384-ejk9wjr1 241 12 published publish VBN cord-026384-ejk9wjr1 241 13 . . . cord-026384-ejk9wjr1 242 1 On on IN cord-026384-ejk9wjr1 242 2 the the DT cord-026384-ejk9wjr1 242 3 influence influence NN cord-026384-ejk9wjr1 242 4 of of IN cord-026384-ejk9wjr1 242 5 abnormal abnormal JJ cord-026384-ejk9wjr1 242 6 parturition parturition NN cord-026384-ejk9wjr1 242 7 , , , cord-026384-ejk9wjr1 242 8 difficult difficult JJ cord-026384-ejk9wjr1 242 9 labours labour NNS cord-026384-ejk9wjr1 242 10 , , , cord-026384-ejk9wjr1 242 11 premature premature JJ cord-026384-ejk9wjr1 242 12 birth birth NN cord-026384-ejk9wjr1 242 13 , , , cord-026384-ejk9wjr1 242 14 and and CC cord-026384-ejk9wjr1 242 15 asphyxia asphyxia NN cord-026384-ejk9wjr1 242 16 neonatorum neonatorum NNP cord-026384-ejk9wjr1 242 17 , , , cord-026384-ejk9wjr1 242 18 on on IN cord-026384-ejk9wjr1 242 19 the the DT cord-026384-ejk9wjr1 242 20 mental mental JJ cord-026384-ejk9wjr1 242 21 and and CC cord-026384-ejk9wjr1 242 22 physical physical JJ cord-026384-ejk9wjr1 242 23 condition condition NN cord-026384-ejk9wjr1 242 24 of of IN cord-026384-ejk9wjr1 242 25 the the DT cord-026384-ejk9wjr1 242 26 child child NN cord-026384-ejk9wjr1 242 27 , , , cord-026384-ejk9wjr1 242 28 especially especially RB cord-026384-ejk9wjr1 242 29 in in IN cord-026384-ejk9wjr1 242 30 relation relation NN cord-026384-ejk9wjr1 242 31 to to IN cord-026384-ejk9wjr1 242 32 deformities deformity NNS cord-026384-ejk9wjr1 242 33 Trends trend NNS cord-026384-ejk9wjr1 242 34 in in IN cord-026384-ejk9wjr1 242 35 care care NN cord-026384-ejk9wjr1 242 36 practices practice NNS cord-026384-ejk9wjr1 242 37 , , , cord-026384-ejk9wjr1 242 38 morbidity morbidity NN cord-026384-ejk9wjr1 242 39 , , , cord-026384-ejk9wjr1 242 40 and and CC cord-026384-ejk9wjr1 242 41 mortality mortality NN cord-026384-ejk9wjr1 242 42 of of IN cord-026384-ejk9wjr1 242 43 extremely extremely RB cord-026384-ejk9wjr1 242 44 preterm preterm JJ cord-026384-ejk9wjr1 242 45 neonates neonate NNS cord-026384-ejk9wjr1 242 46 Survival survival NN cord-026384-ejk9wjr1 242 47 of of IN cord-026384-ejk9wjr1 242 48 infants infant NNS cord-026384-ejk9wjr1 242 49 born bear VBN cord-026384-ejk9wjr1 242 50 at at IN cord-026384-ejk9wjr1 242 51 periviable periviable JJ cord-026384-ejk9wjr1 242 52 gestational gestational JJ cord-026384-ejk9wjr1 242 53 ages age NNS cord-026384-ejk9wjr1 242 54 Outcomes outcome NNS cord-026384-ejk9wjr1 242 55 of of IN cord-026384-ejk9wjr1 242 56 preterm preterm JJ cord-026384-ejk9wjr1 242 57 infants infant NNS cord-026384-ejk9wjr1 242 58 : : : cord-026384-ejk9wjr1 242 59 morbidity morbidity NN cord-026384-ejk9wjr1 242 60 replaces replace VBZ cord-026384-ejk9wjr1 242 61 mortality mortality NNP cord-026384-ejk9wjr1 242 62 Institute Institute NNP cord-026384-ejk9wjr1 242 63 of of IN cord-026384-ejk9wjr1 242 64 Medicine Medicine NNP cord-026384-ejk9wjr1 242 65 Committee Committee NNP cord-026384-ejk9wjr1 242 66 on on IN cord-026384-ejk9wjr1 242 67 Understanding Understanding NNP cord-026384-ejk9wjr1 242 68 Premature Premature NNP cord-026384-ejk9wjr1 242 69 Birth Birth NNP cord-026384-ejk9wjr1 242 70 and and CC cord-026384-ejk9wjr1 242 71 Assuring assure VBG cord-026384-ejk9wjr1 242 72 Healthy Healthy NNP cord-026384-ejk9wjr1 242 73 Outcomes Outcomes NNPS cord-026384-ejk9wjr1 242 74 . . . cord-026384-ejk9wjr1 243 1 Preterm Preterm NNP cord-026384-ejk9wjr1 243 2 Birth birth NN cord-026384-ejk9wjr1 243 3 : : : cord-026384-ejk9wjr1 243 4 Causes cause NNS cord-026384-ejk9wjr1 243 5 , , , cord-026384-ejk9wjr1 243 6 Consequences consequence NNS cord-026384-ejk9wjr1 243 7 , , , cord-026384-ejk9wjr1 243 8 and and CC cord-026384-ejk9wjr1 243 9 Prevention Prevention NNP cord-026384-ejk9wjr1 243 10 Influence influence NN cord-026384-ejk9wjr1 243 11 of of IN cord-026384-ejk9wjr1 243 12 birth birth NN cord-026384-ejk9wjr1 243 13 weight weight NN cord-026384-ejk9wjr1 243 14 , , , cord-026384-ejk9wjr1 243 15 sex sex NN cord-026384-ejk9wjr1 243 16 , , , cord-026384-ejk9wjr1 243 17 and and CC cord-026384-ejk9wjr1 243 18 plurality plurality NN cord-026384-ejk9wjr1 243 19 on on IN cord-026384-ejk9wjr1 243 20 neonatal neonatal JJ cord-026384-ejk9wjr1 243 21 loss loss NN cord-026384-ejk9wjr1 243 22 in in IN cord-026384-ejk9wjr1 243 23 United United NNP cord-026384-ejk9wjr1 243 24 States States NNP cord-026384-ejk9wjr1 243 25 Preterm Preterm NNP cord-026384-ejk9wjr1 243 26 neonatal neonatal JJ cord-026384-ejk9wjr1 243 27 morbidity morbidity NN cord-026384-ejk9wjr1 243 28 and and CC cord-026384-ejk9wjr1 243 29 mortality mortality NN cord-026384-ejk9wjr1 243 30 by by IN cord-026384-ejk9wjr1 243 31 gestational gestational JJ cord-026384-ejk9wjr1 243 32 age age NN cord-026384-ejk9wjr1 243 33 : : : cord-026384-ejk9wjr1 243 34 a a DT cord-026384-ejk9wjr1 243 35 contemporary contemporary JJ cord-026384-ejk9wjr1 243 36 cohort cohort NN cord-026384-ejk9wjr1 243 37 Gestational gestational JJ cord-026384-ejk9wjr1 243 38 age age NN cord-026384-ejk9wjr1 243 39 and and CC cord-026384-ejk9wjr1 243 40 birthweight birthweight JJ cord-026384-ejk9wjr1 243 41 for for IN cord-026384-ejk9wjr1 243 42 risk risk NN cord-026384-ejk9wjr1 243 43 assessment assessment NN cord-026384-ejk9wjr1 243 44 of of IN cord-026384-ejk9wjr1 243 45 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 243 46 impairment impairment NN cord-026384-ejk9wjr1 243 47 or or CC cord-026384-ejk9wjr1 243 48 death death NN cord-026384-ejk9wjr1 243 49 in in IN cord-026384-ejk9wjr1 243 50 extremely extremely RB cord-026384-ejk9wjr1 243 51 preterm preterm JJ cord-026384-ejk9wjr1 243 52 infants infant NNS cord-026384-ejk9wjr1 244 1 Neurodevelopmental neurodevelopmental DT cord-026384-ejk9wjr1 244 2 outcome outcome NN cord-026384-ejk9wjr1 244 3 at at IN cord-026384-ejk9wjr1 244 4 5 5 CD cord-026384-ejk9wjr1 244 5 years year NNS cord-026384-ejk9wjr1 244 6 of of IN cord-026384-ejk9wjr1 244 7 age age NN cord-026384-ejk9wjr1 244 8 of of IN cord-026384-ejk9wjr1 244 9 a a DT cord-026384-ejk9wjr1 244 10 national national JJ cord-026384-ejk9wjr1 244 11 cohort cohort NN cord-026384-ejk9wjr1 244 12 of of IN cord-026384-ejk9wjr1 244 13 extremely extremely RB cord-026384-ejk9wjr1 244 14 low low JJ cord-026384-ejk9wjr1 244 15 birth birth NN cord-026384-ejk9wjr1 244 16 weight weight NN cord-026384-ejk9wjr1 244 17 infants infant NNS cord-026384-ejk9wjr1 244 18 who who WP cord-026384-ejk9wjr1 244 19 were be VBD cord-026384-ejk9wjr1 244 20 born bear VBN cord-026384-ejk9wjr1 244 21 in in IN cord-026384-ejk9wjr1 244 22 1996 1996 CD cord-026384-ejk9wjr1 244 23 - - SYM cord-026384-ejk9wjr1 244 24 1997 1997 CD cord-026384-ejk9wjr1 245 1 Comparing compare VBG cord-026384-ejk9wjr1 245 2 neonatal neonatal JJ cord-026384-ejk9wjr1 245 3 morbidity morbidity NN cord-026384-ejk9wjr1 245 4 and and CC cord-026384-ejk9wjr1 245 5 mortality mortality NN cord-026384-ejk9wjr1 245 6 estimates estimate NNS cord-026384-ejk9wjr1 245 7 across across IN cord-026384-ejk9wjr1 245 8 specialty specialty NN cord-026384-ejk9wjr1 245 9 in in IN cord-026384-ejk9wjr1 245 10 periviable periviable JJ cord-026384-ejk9wjr1 245 11 counseling counseling NN cord-026384-ejk9wjr1 246 1 Prognosis prognosis NN cord-026384-ejk9wjr1 246 2 and and CC cord-026384-ejk9wjr1 246 3 prognostic prognostic JJ cord-026384-ejk9wjr1 246 4 research research NN cord-026384-ejk9wjr1 246 5 : : : cord-026384-ejk9wjr1 247 1 what what WP cord-026384-ejk9wjr1 247 2 , , , cord-026384-ejk9wjr1 247 3 why why WRB cord-026384-ejk9wjr1 247 4 , , , cord-026384-ejk9wjr1 247 5 and and CC cord-026384-ejk9wjr1 247 6 how how WRB cord-026384-ejk9wjr1 247 7 ? ? . cord-026384-ejk9wjr1 248 1 Neonatal neonatal JJ cord-026384-ejk9wjr1 248 2 disease disease NN cord-026384-ejk9wjr1 248 3 severity severity NN cord-026384-ejk9wjr1 248 4 scoring score VBG cord-026384-ejk9wjr1 248 5 systems system NNS cord-026384-ejk9wjr1 248 6 Intensive intensive JJ cord-026384-ejk9wjr1 248 7 care care NN cord-026384-ejk9wjr1 248 8 for for IN cord-026384-ejk9wjr1 248 9 extreme extreme JJ cord-026384-ejk9wjr1 248 10 prematurity prematurity NN cord-026384-ejk9wjr1 248 11 - - HYPH cord-026384-ejk9wjr1 248 12 moving move VBG cord-026384-ejk9wjr1 248 13 beyond beyond IN cord-026384-ejk9wjr1 248 14 gestational gestational JJ cord-026384-ejk9wjr1 248 15 age age NN cord-026384-ejk9wjr1 248 16 Outcome outcome NN cord-026384-ejk9wjr1 248 17 trajectories trajectory NNS cord-026384-ejk9wjr1 248 18 in in IN cord-026384-ejk9wjr1 248 19 extremely extremely RB cord-026384-ejk9wjr1 248 20 preterm preterm JJ cord-026384-ejk9wjr1 248 21 infants infant NNS cord-026384-ejk9wjr1 248 22 Prediction Prediction NNP cord-026384-ejk9wjr1 248 23 of of IN cord-026384-ejk9wjr1 248 24 late late JJ cord-026384-ejk9wjr1 248 25 death death NN cord-026384-ejk9wjr1 248 26 or or CC cord-026384-ejk9wjr1 248 27 disability disability NN cord-026384-ejk9wjr1 248 28 at at IN cord-026384-ejk9wjr1 248 29 age age NN cord-026384-ejk9wjr1 248 30 5 5 CD cord-026384-ejk9wjr1 248 31 years year NNS cord-026384-ejk9wjr1 248 32 using use VBG cord-026384-ejk9wjr1 248 33 a a DT cord-026384-ejk9wjr1 248 34 count count NN cord-026384-ejk9wjr1 248 35 of of IN cord-026384-ejk9wjr1 248 36 3 3 CD cord-026384-ejk9wjr1 248 37 neonatal neonatal JJ cord-026384-ejk9wjr1 248 38 morbidities morbidity NNS cord-026384-ejk9wjr1 248 39 in in IN cord-026384-ejk9wjr1 248 40 very very RB cord-026384-ejk9wjr1 248 41 low low JJ cord-026384-ejk9wjr1 248 42 birth birth NN cord-026384-ejk9wjr1 248 43 weight weight NN cord-026384-ejk9wjr1 248 44 infants infant NNS cord-026384-ejk9wjr1 248 45 Prediction Prediction NNP cord-026384-ejk9wjr1 248 46 of of IN cord-026384-ejk9wjr1 248 47 mortality mortality NN cord-026384-ejk9wjr1 248 48 in in IN cord-026384-ejk9wjr1 248 49 very very RB cord-026384-ejk9wjr1 248 50 premature premature JJ cord-026384-ejk9wjr1 248 51 infants infant NNS cord-026384-ejk9wjr1 248 52 : : : cord-026384-ejk9wjr1 248 53 a a DT cord-026384-ejk9wjr1 248 54 systematic systematic JJ cord-026384-ejk9wjr1 248 55 review review NN cord-026384-ejk9wjr1 248 56 of of IN cord-026384-ejk9wjr1 248 57 prediction prediction NN cord-026384-ejk9wjr1 248 58 models model NNS cord-026384-ejk9wjr1 248 59 Risk risk NN cord-026384-ejk9wjr1 248 60 factor factor NN cord-026384-ejk9wjr1 248 61 models model NNS cord-026384-ejk9wjr1 248 62 for for IN cord-026384-ejk9wjr1 248 63 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 248 64 outcomes outcome NNS cord-026384-ejk9wjr1 248 65 in in IN cord-026384-ejk9wjr1 248 66 children child NNS cord-026384-ejk9wjr1 248 67 born bear VBD cord-026384-ejk9wjr1 248 68 very very RB cord-026384-ejk9wjr1 248 69 preterm preterm NNS cord-026384-ejk9wjr1 248 70 or or CC cord-026384-ejk9wjr1 248 71 with with IN cord-026384-ejk9wjr1 248 72 very very RB cord-026384-ejk9wjr1 248 73 low low JJ cord-026384-ejk9wjr1 248 74 birth birth NN cord-026384-ejk9wjr1 248 75 weight weight NN cord-026384-ejk9wjr1 248 76 : : : cord-026384-ejk9wjr1 249 1 a a DT cord-026384-ejk9wjr1 249 2 systematic systematic JJ cord-026384-ejk9wjr1 249 3 review review NN cord-026384-ejk9wjr1 249 4 of of IN cord-026384-ejk9wjr1 249 5 methodology methodology NN cord-026384-ejk9wjr1 249 6 and and CC cord-026384-ejk9wjr1 249 7 reporting report VBG cord-026384-ejk9wjr1 249 8 A a DT cord-026384-ejk9wjr1 249 9 primer primer NN cord-026384-ejk9wjr1 249 10 on on IN cord-026384-ejk9wjr1 249 11 predictive predictive JJ cord-026384-ejk9wjr1 249 12 models model NNS cord-026384-ejk9wjr1 249 13 Pulmonary pulmonary JJ cord-026384-ejk9wjr1 249 14 surfactant surfactant NN cord-026384-ejk9wjr1 249 15 therapy therapy NN cord-026384-ejk9wjr1 250 1 The the DT cord-026384-ejk9wjr1 250 2 future future NN cord-026384-ejk9wjr1 250 3 of of IN cord-026384-ejk9wjr1 250 4 exogenous exogenous JJ cord-026384-ejk9wjr1 250 5 surfactant surfactant NN cord-026384-ejk9wjr1 250 6 therapy therapy NN cord-026384-ejk9wjr1 250 7 Nursery Nursery NNP cord-026384-ejk9wjr1 250 8 Neurobiologic Neurobiologic NNP cord-026384-ejk9wjr1 250 9 Risk Risk NNP cord-026384-ejk9wjr1 250 10 Score Score NNP cord-026384-ejk9wjr1 250 11 and and CC cord-026384-ejk9wjr1 250 12 outcome outcome NN cord-026384-ejk9wjr1 250 13 at at IN cord-026384-ejk9wjr1 250 14 18 18 CD cord-026384-ejk9wjr1 250 15 months month NNS cord-026384-ejk9wjr1 250 16 Evaluation Evaluation NNP cord-026384-ejk9wjr1 250 17 of of IN cord-026384-ejk9wjr1 250 18 the the DT cord-026384-ejk9wjr1 250 19 ability ability NN cord-026384-ejk9wjr1 250 20 of of IN cord-026384-ejk9wjr1 250 21 neurobiological neurobiological JJ cord-026384-ejk9wjr1 250 22 , , , cord-026384-ejk9wjr1 250 23 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 250 24 and and CC cord-026384-ejk9wjr1 250 25 socio socio JJ cord-026384-ejk9wjr1 250 26 - - HYPH cord-026384-ejk9wjr1 250 27 economic economic JJ cord-026384-ejk9wjr1 250 28 variables variable NNS cord-026384-ejk9wjr1 250 29 to to TO cord-026384-ejk9wjr1 250 30 predict predict VB cord-026384-ejk9wjr1 250 31 cognitive cognitive JJ cord-026384-ejk9wjr1 250 32 outcome outcome NN cord-026384-ejk9wjr1 250 33 in in IN cord-026384-ejk9wjr1 250 34 premature premature JJ cord-026384-ejk9wjr1 250 35 infants infant NNS cord-026384-ejk9wjr1 250 36 . . . cord-026384-ejk9wjr1 251 1 Child Child NNP cord-026384-ejk9wjr1 251 2 Care Care NNP cord-026384-ejk9wjr1 251 3 Health Health NNP cord-026384-ejk9wjr1 251 4 Dev Dev NNP cord-026384-ejk9wjr1 251 5 Increased increase VBN cord-026384-ejk9wjr1 251 6 survival survival NN cord-026384-ejk9wjr1 251 7 and and CC cord-026384-ejk9wjr1 251 8 deteriorating deteriorate VBG cord-026384-ejk9wjr1 251 9 developmental developmental JJ cord-026384-ejk9wjr1 251 10 outcome outcome NN cord-026384-ejk9wjr1 251 11 in in IN cord-026384-ejk9wjr1 251 12 23 23 CD cord-026384-ejk9wjr1 251 13 to to TO cord-026384-ejk9wjr1 251 14 25 25 CD cord-026384-ejk9wjr1 251 15 week week NN cord-026384-ejk9wjr1 251 16 old old JJ cord-026384-ejk9wjr1 251 17 gestation gestation NN cord-026384-ejk9wjr1 251 18 infants infant NNS cord-026384-ejk9wjr1 251 19 , , , cord-026384-ejk9wjr1 251 20 1990 1990 CD cord-026384-ejk9wjr1 251 21 - - SYM cord-026384-ejk9wjr1 251 22 4 4 CD cord-026384-ejk9wjr1 251 23 compared compare VBN cord-026384-ejk9wjr1 251 24 with with IN cord-026384-ejk9wjr1 251 25 1984 1984 CD cord-026384-ejk9wjr1 251 26 - - SYM cord-026384-ejk9wjr1 251 27 9 9 CD cord-026384-ejk9wjr1 251 28 Measurement Measurement NNP cord-026384-ejk9wjr1 251 29 properties property NNS cord-026384-ejk9wjr1 251 30 of of IN cord-026384-ejk9wjr1 251 31 the the DT cord-026384-ejk9wjr1 251 32 Clinical Clinical NNP cord-026384-ejk9wjr1 251 33 Risk Risk NNP cord-026384-ejk9wjr1 251 34 Index Index NNP cord-026384-ejk9wjr1 251 35 for for IN cord-026384-ejk9wjr1 251 36 Babies baby NNS cord-026384-ejk9wjr1 251 37 - - : cord-026384-ejk9wjr1 251 38 reliabilty reliabilty NN cord-026384-ejk9wjr1 251 39 , , , cord-026384-ejk9wjr1 251 40 validity validity NN cord-026384-ejk9wjr1 251 41 beyond beyond IN cord-026384-ejk9wjr1 251 42 the the DT cord-026384-ejk9wjr1 251 43 first first JJ cord-026384-ejk9wjr1 251 44 12 12 CD cord-026384-ejk9wjr1 251 45 hours hour NNS cord-026384-ejk9wjr1 251 46 , , , cord-026384-ejk9wjr1 251 47 and and CC cord-026384-ejk9wjr1 251 48 responsiveness responsiveness NN cord-026384-ejk9wjr1 251 49 over over IN cord-026384-ejk9wjr1 251 50 7 7 CD cord-026384-ejk9wjr1 251 51 days day NNS cord-026384-ejk9wjr1 251 52 Predicting predict VBG cord-026384-ejk9wjr1 251 53 the the DT cord-026384-ejk9wjr1 251 54 outcomes outcome NNS cord-026384-ejk9wjr1 251 55 of of IN cord-026384-ejk9wjr1 251 56 preterm preterm JJ cord-026384-ejk9wjr1 251 57 neonates neonate NNS cord-026384-ejk9wjr1 251 58 beyond beyond IN cord-026384-ejk9wjr1 251 59 the the DT cord-026384-ejk9wjr1 251 60 neonatal neonatal JJ cord-026384-ejk9wjr1 251 61 intensive intensive JJ cord-026384-ejk9wjr1 252 1 Predicting predict VBG cord-026384-ejk9wjr1 252 2 outcome outcome NN cord-026384-ejk9wjr1 252 3 in in IN cord-026384-ejk9wjr1 252 4 very very RB cord-026384-ejk9wjr1 252 5 low low JJ cord-026384-ejk9wjr1 252 6 birthweight birthweight JJ cord-026384-ejk9wjr1 252 7 infants infant NNS cord-026384-ejk9wjr1 252 8 using use VBG cord-026384-ejk9wjr1 252 9 an an DT cord-026384-ejk9wjr1 252 10 objective objective JJ cord-026384-ejk9wjr1 252 11 measure measure NN cord-026384-ejk9wjr1 252 12 of of IN cord-026384-ejk9wjr1 252 13 illness illness NN cord-026384-ejk9wjr1 252 14 severity severity NN cord-026384-ejk9wjr1 252 15 and and CC cord-026384-ejk9wjr1 252 16 cranial cranial JJ cord-026384-ejk9wjr1 252 17 ultrasound ultrasound NN cord-026384-ejk9wjr1 252 18 scanning scanning NN cord-026384-ejk9wjr1 252 19 Is be VBZ cord-026384-ejk9wjr1 252 20 the the DT cord-026384-ejk9wjr1 252 21 CRIB CRIB NNP cord-026384-ejk9wjr1 252 22 score score NN cord-026384-ejk9wjr1 252 23 ( ( -LRB- cord-026384-ejk9wjr1 252 24 Clinical Clinical NNP cord-026384-ejk9wjr1 252 25 Risk Risk NNP cord-026384-ejk9wjr1 252 26 Index Index NNP cord-026384-ejk9wjr1 252 27 for for IN cord-026384-ejk9wjr1 252 28 babies baby NNS cord-026384-ejk9wjr1 252 29 ) ) -RRB- cord-026384-ejk9wjr1 252 30 a a DT cord-026384-ejk9wjr1 252 31 valid valid JJ cord-026384-ejk9wjr1 252 32 tool tool NN cord-026384-ejk9wjr1 252 33 in in IN cord-026384-ejk9wjr1 252 34 predicting predict VBG cord-026384-ejk9wjr1 252 35 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 252 36 outcome outcome NN cord-026384-ejk9wjr1 252 37 in in IN cord-026384-ejk9wjr1 252 38 extremely extremely RB cord-026384-ejk9wjr1 252 39 low low JJ cord-026384-ejk9wjr1 252 40 birth birth NN cord-026384-ejk9wjr1 252 41 weight weight NN cord-026384-ejk9wjr1 252 42 infants infant NNS cord-026384-ejk9wjr1 252 43 ? ? . cord-026384-ejk9wjr1 253 1 The the DT cord-026384-ejk9wjr1 253 2 CRIB crib NN cord-026384-ejk9wjr1 253 3 ( ( -LRB- cord-026384-ejk9wjr1 253 4 Clinical Clinical NNP cord-026384-ejk9wjr1 253 5 Risk Risk NNP cord-026384-ejk9wjr1 253 6 Index Index NNP cord-026384-ejk9wjr1 253 7 for for IN cord-026384-ejk9wjr1 253 8 Babies baby NNS cord-026384-ejk9wjr1 253 9 ) ) -RRB- cord-026384-ejk9wjr1 253 10 score score VBP cord-026384-ejk9wjr1 253 11 and and CC cord-026384-ejk9wjr1 253 12 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 253 13 impairment impairment NN cord-026384-ejk9wjr1 253 14 at at IN cord-026384-ejk9wjr1 253 15 one one CD cord-026384-ejk9wjr1 253 16 year year NN cord-026384-ejk9wjr1 253 17 corrected correct VBD cord-026384-ejk9wjr1 253 18 age age NN cord-026384-ejk9wjr1 253 19 in in IN cord-026384-ejk9wjr1 253 20 very very RB cord-026384-ejk9wjr1 253 21 low low JJ cord-026384-ejk9wjr1 253 22 birth birth NN cord-026384-ejk9wjr1 253 23 weight weight NN cord-026384-ejk9wjr1 253 24 infants infant NNS cord-026384-ejk9wjr1 253 25 Can Can MD cord-026384-ejk9wjr1 253 26 severity severity NN cord-026384-ejk9wjr1 253 27 - - HYPH cord-026384-ejk9wjr1 253 28 of of IN cord-026384-ejk9wjr1 253 29 - - HYPH cord-026384-ejk9wjr1 253 30 illness illness NN cord-026384-ejk9wjr1 253 31 indices index NNS cord-026384-ejk9wjr1 253 32 for for IN cord-026384-ejk9wjr1 253 33 neonatal neonatal JJ cord-026384-ejk9wjr1 253 34 intensive intensive JJ cord-026384-ejk9wjr1 253 35 care care NN cord-026384-ejk9wjr1 253 36 predict predict VBP cord-026384-ejk9wjr1 253 37 outcome outcome NN cord-026384-ejk9wjr1 253 38 at at IN cord-026384-ejk9wjr1 253 39 4 4 CD cord-026384-ejk9wjr1 253 40 years year NNS cord-026384-ejk9wjr1 253 41 of of IN cord-026384-ejk9wjr1 253 42 age age NN cord-026384-ejk9wjr1 253 43 ? ? . cord-026384-ejk9wjr1 254 1 Neurodevelopment Neurodevelopment NNP cord-026384-ejk9wjr1 254 2 of of IN cord-026384-ejk9wjr1 254 3 children child NNS cord-026384-ejk9wjr1 254 4 born bear VBD cord-026384-ejk9wjr1 254 5 very very RB cord-026384-ejk9wjr1 254 6 preterm preterm NNS cord-026384-ejk9wjr1 254 7 and and CC cord-026384-ejk9wjr1 254 8 free free JJ cord-026384-ejk9wjr1 254 9 of of IN cord-026384-ejk9wjr1 254 10 severe severe JJ cord-026384-ejk9wjr1 254 11 disabilities disability NNS cord-026384-ejk9wjr1 254 12 : : : cord-026384-ejk9wjr1 254 13 the the DT cord-026384-ejk9wjr1 254 14 Nord Nord NNP cord-026384-ejk9wjr1 254 15 - - HYPH cord-026384-ejk9wjr1 254 16 Pas Pas NNP cord-026384-ejk9wjr1 254 17 de de FW cord-026384-ejk9wjr1 254 18 Calais Calais NNP cord-026384-ejk9wjr1 254 19 Epipage Epipage NNP cord-026384-ejk9wjr1 254 20 cohort cohort NN cord-026384-ejk9wjr1 254 21 study study NN cord-026384-ejk9wjr1 254 22 Chronic chronic JJ cord-026384-ejk9wjr1 254 23 physiologic physiologic JJ cord-026384-ejk9wjr1 254 24 instability instability NN cord-026384-ejk9wjr1 254 25 is be VBZ cord-026384-ejk9wjr1 254 26 associated associate VBN cord-026384-ejk9wjr1 254 27 with with IN cord-026384-ejk9wjr1 254 28 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 254 29 morbidity morbidity NN cord-026384-ejk9wjr1 254 30 at at IN cord-026384-ejk9wjr1 254 31 one one CD cord-026384-ejk9wjr1 254 32 and and CC cord-026384-ejk9wjr1 254 33 two two CD cord-026384-ejk9wjr1 254 34 years year NNS cord-026384-ejk9wjr1 254 35 in in IN cord-026384-ejk9wjr1 254 36 extremely extremely RB cord-026384-ejk9wjr1 254 37 premature premature JJ cord-026384-ejk9wjr1 254 38 infants infant NNS cord-026384-ejk9wjr1 254 39 Prediction Prediction NNP cord-026384-ejk9wjr1 254 40 of of IN cord-026384-ejk9wjr1 254 41 neurologic neurologic JJ cord-026384-ejk9wjr1 254 42 morbidity morbidity NN cord-026384-ejk9wjr1 254 43 in in IN cord-026384-ejk9wjr1 254 44 extremely extremely RB cord-026384-ejk9wjr1 254 45 low low JJ cord-026384-ejk9wjr1 254 46 birth birth NN cord-026384-ejk9wjr1 254 47 weight weight NN cord-026384-ejk9wjr1 254 48 infants infant NNS cord-026384-ejk9wjr1 254 49 Impact Impact NNP cord-026384-ejk9wjr1 254 50 of of IN cord-026384-ejk9wjr1 254 51 bronchopulmonary bronchopulmonary JJ cord-026384-ejk9wjr1 254 52 dysplasia dysplasia NN cord-026384-ejk9wjr1 254 53 , , , cord-026384-ejk9wjr1 254 54 brain brain NN cord-026384-ejk9wjr1 254 55 injury injury NN cord-026384-ejk9wjr1 254 56 , , , cord-026384-ejk9wjr1 254 57 and and CC cord-026384-ejk9wjr1 254 58 severe severe JJ cord-026384-ejk9wjr1 254 59 retinopathy retinopathy NN cord-026384-ejk9wjr1 254 60 on on IN cord-026384-ejk9wjr1 254 61 the the DT cord-026384-ejk9wjr1 254 62 outcome outcome NN cord-026384-ejk9wjr1 254 63 of of IN cord-026384-ejk9wjr1 254 64 extremely extremely RB cord-026384-ejk9wjr1 254 65 low low JJ cord-026384-ejk9wjr1 254 66 - - HYPH cord-026384-ejk9wjr1 254 67 birth birth NN cord-026384-ejk9wjr1 254 68 - - HYPH cord-026384-ejk9wjr1 254 69 weight weight NN cord-026384-ejk9wjr1 254 70 infants infant NNS cord-026384-ejk9wjr1 254 71 at at IN cord-026384-ejk9wjr1 254 72 18 18 CD cord-026384-ejk9wjr1 254 73 months month NNS cord-026384-ejk9wjr1 254 74 : : : cord-026384-ejk9wjr1 254 75 results result NNS cord-026384-ejk9wjr1 254 76 from from IN cord-026384-ejk9wjr1 254 77 the the DT cord-026384-ejk9wjr1 254 78 trial trial NN cord-026384-ejk9wjr1 254 79 of of IN cord-026384-ejk9wjr1 254 80 indomethacin indomethacin JJ cord-026384-ejk9wjr1 254 81 prophylaxis prophylaxis NN cord-026384-ejk9wjr1 254 82 in in IN cord-026384-ejk9wjr1 254 83 preterms preterms NNP cord-026384-ejk9wjr1 254 84 Impact Impact NNP cord-026384-ejk9wjr1 254 85 at at IN cord-026384-ejk9wjr1 254 86 age age NN cord-026384-ejk9wjr1 254 87 11 11 CD cord-026384-ejk9wjr1 254 88 years year NNS cord-026384-ejk9wjr1 254 89 of of IN cord-026384-ejk9wjr1 254 90 major major JJ cord-026384-ejk9wjr1 254 91 neonatal neonatal JJ cord-026384-ejk9wjr1 254 92 morbidities morbidity NNS cord-026384-ejk9wjr1 254 93 in in IN cord-026384-ejk9wjr1 254 94 children child NNS cord-026384-ejk9wjr1 254 95 born bear VBD cord-026384-ejk9wjr1 254 96 extremely extremely RB cord-026384-ejk9wjr1 254 97 preterm preterm JJR cord-026384-ejk9wjr1 254 98 Effect effect NN cord-026384-ejk9wjr1 254 99 of of IN cord-026384-ejk9wjr1 254 100 severe severe JJ cord-026384-ejk9wjr1 254 101 neonatal neonatal JJ cord-026384-ejk9wjr1 254 102 morbidities morbidity NNS cord-026384-ejk9wjr1 254 103 on on IN cord-026384-ejk9wjr1 254 104 long long JJ cord-026384-ejk9wjr1 254 105 term term NN cord-026384-ejk9wjr1 254 106 outcome outcome NN cord-026384-ejk9wjr1 254 107 in in IN cord-026384-ejk9wjr1 254 108 extremely extremely RB cord-026384-ejk9wjr1 254 109 low low JJ cord-026384-ejk9wjr1 254 110 birthweight birthweight JJ cord-026384-ejk9wjr1 254 111 infants infant NNS cord-026384-ejk9wjr1 254 112 Early early JJ cord-026384-ejk9wjr1 254 113 prediction prediction NN cord-026384-ejk9wjr1 254 114 of of IN cord-026384-ejk9wjr1 254 115 poor poor JJ cord-026384-ejk9wjr1 254 116 outcome outcome NN cord-026384-ejk9wjr1 254 117 in in IN cord-026384-ejk9wjr1 254 118 extremely extremely RB cord-026384-ejk9wjr1 254 119 low low JJ cord-026384-ejk9wjr1 254 120 birth birth NN cord-026384-ejk9wjr1 254 121 weight weight NN cord-026384-ejk9wjr1 254 122 infants infant NNS cord-026384-ejk9wjr1 254 123 by by IN cord-026384-ejk9wjr1 254 124 classification classification NN cord-026384-ejk9wjr1 254 125 tree tree NN cord-026384-ejk9wjr1 254 126 analysis analysis NN cord-026384-ejk9wjr1 254 127 Consequences consequence NNS cord-026384-ejk9wjr1 254 128 and and CC cord-026384-ejk9wjr1 254 129 risks risk NNS cord-026384-ejk9wjr1 254 130 of of IN cord-026384-ejk9wjr1 254 131 < < NNP cord-026384-ejk9wjr1 254 132 1000-g 1000-g CD cord-026384-ejk9wjr1 254 133 birth birth NN cord-026384-ejk9wjr1 254 134 weight weight NN cord-026384-ejk9wjr1 254 135 for for IN cord-026384-ejk9wjr1 254 136 neuropsychological neuropsychological JJ cord-026384-ejk9wjr1 254 137 skills skill NNS cord-026384-ejk9wjr1 254 138 , , , cord-026384-ejk9wjr1 254 139 achievement achievement NN cord-026384-ejk9wjr1 254 140 , , , cord-026384-ejk9wjr1 254 141 and and CC cord-026384-ejk9wjr1 254 142 adaptive adaptive JJ cord-026384-ejk9wjr1 254 143 functioning function VBG cord-026384-ejk9wjr1 254 144 Clinical clinical JJ cord-026384-ejk9wjr1 254 145 data datum NNS cord-026384-ejk9wjr1 255 1 predict predict VB cord-026384-ejk9wjr1 255 2 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 255 3 outcome outcome NN cord-026384-ejk9wjr1 255 4 better well RBR cord-026384-ejk9wjr1 255 5 than than IN cord-026384-ejk9wjr1 255 6 head head NN cord-026384-ejk9wjr1 255 7 ultrasound ultrasound NN cord-026384-ejk9wjr1 255 8 in in IN cord-026384-ejk9wjr1 255 9 extremely extremely RB cord-026384-ejk9wjr1 255 10 low low JJ cord-026384-ejk9wjr1 255 11 birth birth NN cord-026384-ejk9wjr1 255 12 weight weight NN cord-026384-ejk9wjr1 255 13 infants infant NNS cord-026384-ejk9wjr1 256 1 Infant infant NN cord-026384-ejk9wjr1 256 2 outcomes outcome NNS cord-026384-ejk9wjr1 256 3 after after IN cord-026384-ejk9wjr1 256 4 periviable periviable JJ cord-026384-ejk9wjr1 256 5 birth birth NN cord-026384-ejk9wjr1 256 6 ; ; , cord-026384-ejk9wjr1 256 7 external external JJ cord-026384-ejk9wjr1 256 8 validation validation NN cord-026384-ejk9wjr1 256 9 of of IN cord-026384-ejk9wjr1 256 10 the the DT cord-026384-ejk9wjr1 256 11 neonatal neonatal JJ cord-026384-ejk9wjr1 256 12 research research NN cord-026384-ejk9wjr1 256 13 network network NN cord-026384-ejk9wjr1 256 14 estimator estimator NN cord-026384-ejk9wjr1 256 15 with with IN cord-026384-ejk9wjr1 256 16 the the DT cord-026384-ejk9wjr1 256 17 BEAM BEAM NNP cord-026384-ejk9wjr1 256 18 Trial Trial NNP cord-026384-ejk9wjr1 256 19 Clinical Clinical NNP cord-026384-ejk9wjr1 256 20 Risk Risk NNP cord-026384-ejk9wjr1 256 21 Index Index NNP cord-026384-ejk9wjr1 256 22 for for IN cord-026384-ejk9wjr1 256 23 Babies baby NNS cord-026384-ejk9wjr1 256 24 score score VBP cord-026384-ejk9wjr1 256 25 for for IN cord-026384-ejk9wjr1 256 26 the the DT cord-026384-ejk9wjr1 256 27 prediction prediction NN cord-026384-ejk9wjr1 256 28 of of IN cord-026384-ejk9wjr1 256 29 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 256 30 outcomes outcome NNS cord-026384-ejk9wjr1 256 31 at at IN cord-026384-ejk9wjr1 256 32 3 3 CD cord-026384-ejk9wjr1 256 33 years year NNS cord-026384-ejk9wjr1 256 34 of of IN cord-026384-ejk9wjr1 256 35 age age NN cord-026384-ejk9wjr1 256 36 in in IN cord-026384-ejk9wjr1 256 37 infants infant NNS cord-026384-ejk9wjr1 256 38 of of IN cord-026384-ejk9wjr1 256 39 very very RB cord-026384-ejk9wjr1 256 40 low low JJ cord-026384-ejk9wjr1 256 41 birthweight birthweight JJ cord-026384-ejk9wjr1 256 42 NSW NSW NNP cord-026384-ejk9wjr1 256 43 and and CC cord-026384-ejk9wjr1 256 44 ACT ACT NNP cord-026384-ejk9wjr1 256 45 Neonatal Neonatal NNP cord-026384-ejk9wjr1 256 46 Intensive Intensive NNP cord-026384-ejk9wjr1 256 47 Care Care NNP cord-026384-ejk9wjr1 256 48 Units Units NNPS cord-026384-ejk9wjr1 256 49 Audit Audit NNP cord-026384-ejk9wjr1 256 50 Group Group NNP cord-026384-ejk9wjr1 256 51 . . . cord-026384-ejk9wjr1 257 1 Can Can MD cord-026384-ejk9wjr1 257 2 the the DT cord-026384-ejk9wjr1 257 3 early early JJ cord-026384-ejk9wjr1 257 4 condition condition NN cord-026384-ejk9wjr1 257 5 at at IN cord-026384-ejk9wjr1 257 6 admission admission NN cord-026384-ejk9wjr1 257 7 of of IN cord-026384-ejk9wjr1 257 8 a a DT cord-026384-ejk9wjr1 257 9 high high JJ cord-026384-ejk9wjr1 257 10 - - HYPH cord-026384-ejk9wjr1 257 11 risk risk NN cord-026384-ejk9wjr1 257 12 infant infant NN cord-026384-ejk9wjr1 257 13 aid aid NN cord-026384-ejk9wjr1 257 14 in in IN cord-026384-ejk9wjr1 257 15 the the DT cord-026384-ejk9wjr1 257 16 prediction prediction NN cord-026384-ejk9wjr1 257 17 of of IN cord-026384-ejk9wjr1 257 18 mortality mortality NN cord-026384-ejk9wjr1 257 19 and and CC cord-026384-ejk9wjr1 257 20 poor poor JJ cord-026384-ejk9wjr1 257 21 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 257 22 outcome outcome NN cord-026384-ejk9wjr1 257 23 ? ? . cord-026384-ejk9wjr1 258 1 A a DT cord-026384-ejk9wjr1 258 2 population population NN cord-026384-ejk9wjr1 258 3 study study NN cord-026384-ejk9wjr1 258 4 in in IN cord-026384-ejk9wjr1 258 5 Australia Australia NNP cord-026384-ejk9wjr1 258 6 Autism Autism NNP cord-026384-ejk9wjr1 258 7 spectrum spectrum NN cord-026384-ejk9wjr1 258 8 disorders disorder NNS cord-026384-ejk9wjr1 258 9 in in IN cord-026384-ejk9wjr1 258 10 extremely extremely RB cord-026384-ejk9wjr1 258 11 preterm preterm JJ cord-026384-ejk9wjr1 258 12 children child NNS cord-026384-ejk9wjr1 258 13 SNAP snap VB cord-026384-ejk9wjr1 258 14 - - HYPH cord-026384-ejk9wjr1 258 15 II II NNP cord-026384-ejk9wjr1 258 16 and and CC cord-026384-ejk9wjr1 258 17 SNAPPE SNAPPE NNP cord-026384-ejk9wjr1 258 18 - - HYPH cord-026384-ejk9wjr1 258 19 II II NNP cord-026384-ejk9wjr1 258 20 and and CC cord-026384-ejk9wjr1 258 21 the the DT cord-026384-ejk9wjr1 258 22 risk risk NN cord-026384-ejk9wjr1 258 23 of of IN cord-026384-ejk9wjr1 258 24 structural structural JJ cord-026384-ejk9wjr1 258 25 and and CC cord-026384-ejk9wjr1 258 26 functional functional JJ cord-026384-ejk9wjr1 258 27 brain brain NN cord-026384-ejk9wjr1 258 28 disorders disorder NNS cord-026384-ejk9wjr1 258 29 in in IN cord-026384-ejk9wjr1 258 30 extremely extremely RB cord-026384-ejk9wjr1 258 31 low low JJ cord-026384-ejk9wjr1 258 32 gestational gestational JJ cord-026384-ejk9wjr1 258 33 age age NN cord-026384-ejk9wjr1 258 34 newborns newborn NNS cord-026384-ejk9wjr1 258 35 : : : cord-026384-ejk9wjr1 258 36 the the DT cord-026384-ejk9wjr1 258 37 ELGAN ELGAN NNP cord-026384-ejk9wjr1 258 38 study study NN cord-026384-ejk9wjr1 258 39 Early early JJ cord-026384-ejk9wjr1 258 40 postnatal postnatal JJ cord-026384-ejk9wjr1 258 41 illness illness NN cord-026384-ejk9wjr1 258 42 severity severity NN cord-026384-ejk9wjr1 258 43 scores score NNS cord-026384-ejk9wjr1 258 44 predict predict VBP cord-026384-ejk9wjr1 258 45 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 258 46 impairments impairment NNS cord-026384-ejk9wjr1 258 47 at at IN cord-026384-ejk9wjr1 258 48 10 10 CD cord-026384-ejk9wjr1 258 49 years year NNS cord-026384-ejk9wjr1 258 50 of of IN cord-026384-ejk9wjr1 258 51 age age NN cord-026384-ejk9wjr1 258 52 in in IN cord-026384-ejk9wjr1 258 53 children child NNS cord-026384-ejk9wjr1 258 54 born bear VBD cord-026384-ejk9wjr1 258 55 extremely extremely RB cord-026384-ejk9wjr1 258 56 preterm preterm NNS cord-026384-ejk9wjr1 258 57 High high JJ cord-026384-ejk9wjr1 258 58 prevalence prevalence NN cord-026384-ejk9wjr1 258 59 / / SYM cord-026384-ejk9wjr1 258 60 low low JJ cord-026384-ejk9wjr1 258 61 severity severity NN cord-026384-ejk9wjr1 258 62 language language NN cord-026384-ejk9wjr1 258 63 delay delay NN cord-026384-ejk9wjr1 258 64 in in IN cord-026384-ejk9wjr1 258 65 preschool preschool NN cord-026384-ejk9wjr1 258 66 children child NNS cord-026384-ejk9wjr1 258 67 born bear VBD cord-026384-ejk9wjr1 258 68 very very RB cord-026384-ejk9wjr1 258 69 preterm preterm JJR cord-026384-ejk9wjr1 258 70 Identification identification NN cord-026384-ejk9wjr1 258 71 of of IN cord-026384-ejk9wjr1 258 72 extremely extremely RB cord-026384-ejk9wjr1 258 73 premature premature JJ cord-026384-ejk9wjr1 258 74 infants infant NNS cord-026384-ejk9wjr1 258 75 at at IN cord-026384-ejk9wjr1 258 76 high high JJ cord-026384-ejk9wjr1 258 77 risk risk NN cord-026384-ejk9wjr1 258 78 of of IN cord-026384-ejk9wjr1 258 79 rehospitalization rehospitalization NN cord-026384-ejk9wjr1 258 80 Screening Screening NNP cord-026384-ejk9wjr1 258 81 for for IN cord-026384-ejk9wjr1 258 82 autism autism NN cord-026384-ejk9wjr1 258 83 spectrum spectrum NN cord-026384-ejk9wjr1 258 84 disorders disorder NNS cord-026384-ejk9wjr1 258 85 in in IN cord-026384-ejk9wjr1 258 86 extremely extremely RB cord-026384-ejk9wjr1 258 87 preterm preterm JJ cord-026384-ejk9wjr1 258 88 infants infant NNS cord-026384-ejk9wjr1 259 1 Perinatal perinatal JJ cord-026384-ejk9wjr1 259 2 risk risk NN cord-026384-ejk9wjr1 259 3 factors factor NNS cord-026384-ejk9wjr1 259 4 for for IN cord-026384-ejk9wjr1 259 5 neurocognitive neurocognitive JJ cord-026384-ejk9wjr1 259 6 impairments impairment NNS cord-026384-ejk9wjr1 259 7 in in IN cord-026384-ejk9wjr1 259 8 preschool preschool NN cord-026384-ejk9wjr1 259 9 children child NNS cord-026384-ejk9wjr1 259 10 born bear VBD cord-026384-ejk9wjr1 259 11 very very RB cord-026384-ejk9wjr1 259 12 preterm preterm JJR cord-026384-ejk9wjr1 259 13 Correlation correlation NN cord-026384-ejk9wjr1 259 14 between between IN cord-026384-ejk9wjr1 259 15 initial initial JJ cord-026384-ejk9wjr1 259 16 neonatal neonatal JJ cord-026384-ejk9wjr1 259 17 and and CC cord-026384-ejk9wjr1 259 18 early early JJ cord-026384-ejk9wjr1 259 19 childhood childhood NN cord-026384-ejk9wjr1 259 20 outcomes outcome NNS cord-026384-ejk9wjr1 259 21 following follow VBG cord-026384-ejk9wjr1 259 22 preterm preterm NNS cord-026384-ejk9wjr1 259 23 birth birth NN cord-026384-ejk9wjr1 259 24 Bronchopulmonary Bronchopulmonary NNP cord-026384-ejk9wjr1 259 25 dysplasia dysplasia NN cord-026384-ejk9wjr1 259 26 and and CC cord-026384-ejk9wjr1 259 27 perinatal perinatal JJ cord-026384-ejk9wjr1 259 28 characteristics characteristic NNS cord-026384-ejk9wjr1 260 1 predict predict VB cord-026384-ejk9wjr1 260 2 1-year 1-year CD cord-026384-ejk9wjr1 260 3 respiratory respiratory JJ cord-026384-ejk9wjr1 260 4 outcomes outcome NNS cord-026384-ejk9wjr1 260 5 in in IN cord-026384-ejk9wjr1 260 6 newborns newborn NNS cord-026384-ejk9wjr1 260 7 born bear VBN cord-026384-ejk9wjr1 260 8 at at IN cord-026384-ejk9wjr1 260 9 extremely extremely RB cord-026384-ejk9wjr1 260 10 low low JJ cord-026384-ejk9wjr1 260 11 gestational gestational JJ cord-026384-ejk9wjr1 260 12 age age NN cord-026384-ejk9wjr1 260 13 : : : cord-026384-ejk9wjr1 260 14 a a DT cord-026384-ejk9wjr1 260 15 prospective prospective JJ cord-026384-ejk9wjr1 260 16 cohort cohort NN cord-026384-ejk9wjr1 260 17 study study NN cord-026384-ejk9wjr1 260 18 The the DT cord-026384-ejk9wjr1 260 19 International International NNP cord-026384-ejk9wjr1 260 20 Neonatal Neonatal NNP cord-026384-ejk9wjr1 260 21 Network Network NNP cord-026384-ejk9wjr1 260 22 . . . cord-026384-ejk9wjr1 261 1 The the DT cord-026384-ejk9wjr1 261 2 CRIB crib NN cord-026384-ejk9wjr1 261 3 ( ( -LRB- cord-026384-ejk9wjr1 261 4 Clinical Clinical NNP cord-026384-ejk9wjr1 261 5 Risk Risk NNP cord-026384-ejk9wjr1 261 6 Index Index NNP cord-026384-ejk9wjr1 261 7 for for IN cord-026384-ejk9wjr1 261 8 Babies baby NNS cord-026384-ejk9wjr1 261 9 ) ) -RRB- cord-026384-ejk9wjr1 261 10 score score VBP cord-026384-ejk9wjr1 261 11 : : : cord-026384-ejk9wjr1 261 12 a a DT cord-026384-ejk9wjr1 261 13 tool tool NN cord-026384-ejk9wjr1 261 14 for for IN cord-026384-ejk9wjr1 261 15 assessing assess VBG cord-026384-ejk9wjr1 261 16 initial initial JJ cord-026384-ejk9wjr1 261 17 neonatal neonatal JJ cord-026384-ejk9wjr1 261 18 risk risk NN cord-026384-ejk9wjr1 261 19 and and CC cord-026384-ejk9wjr1 261 20 comparing compare VBG cord-026384-ejk9wjr1 261 21 performance performance NN cord-026384-ejk9wjr1 261 22 of of IN cord-026384-ejk9wjr1 261 23 neonatal neonatal JJ cord-026384-ejk9wjr1 261 24 intensive intensive JJ cord-026384-ejk9wjr1 261 25 care care NN cord-026384-ejk9wjr1 261 26 units unit NNS cord-026384-ejk9wjr1 261 27 Score score VBP cord-026384-ejk9wjr1 261 28 for for IN cord-026384-ejk9wjr1 261 29 neonatal neonatal JJ cord-026384-ejk9wjr1 261 30 acute acute JJ cord-026384-ejk9wjr1 261 31 physiology physiology NN cord-026384-ejk9wjr1 261 32 : : : cord-026384-ejk9wjr1 261 33 a a DT cord-026384-ejk9wjr1 261 34 physiologic physiologic JJ cord-026384-ejk9wjr1 261 35 severity severity NN cord-026384-ejk9wjr1 261 36 index index NN cord-026384-ejk9wjr1 261 37 for for IN cord-026384-ejk9wjr1 261 38 neonatal neonatal JJ cord-026384-ejk9wjr1 261 39 intensive intensive JJ cord-026384-ejk9wjr1 261 40 care care NN cord-026384-ejk9wjr1 261 41 Neonatal neonatal JJ cord-026384-ejk9wjr1 261 42 therapeutic therapeutic JJ cord-026384-ejk9wjr1 261 43 intervention intervention NN cord-026384-ejk9wjr1 261 44 scoring scoring NN cord-026384-ejk9wjr1 261 45 system system NN cord-026384-ejk9wjr1 261 46 : : : cord-026384-ejk9wjr1 261 47 a a DT cord-026384-ejk9wjr1 261 48 therapy therapy NN cord-026384-ejk9wjr1 261 49 - - HYPH cord-026384-ejk9wjr1 261 50 based base VBN cord-026384-ejk9wjr1 261 51 severity severity NN cord-026384-ejk9wjr1 261 52 - - HYPH cord-026384-ejk9wjr1 261 53 of of IN cord-026384-ejk9wjr1 261 54 - - HYPH cord-026384-ejk9wjr1 261 55 illness illness NN cord-026384-ejk9wjr1 261 56 index index NN cord-026384-ejk9wjr1 261 57 Prediction Prediction NNP cord-026384-ejk9wjr1 261 58 of of IN cord-026384-ejk9wjr1 261 59 death death NN cord-026384-ejk9wjr1 261 60 for for IN cord-026384-ejk9wjr1 261 61 extremely extremely RB cord-026384-ejk9wjr1 261 62 premature premature JJ cord-026384-ejk9wjr1 261 63 infants infant NNS cord-026384-ejk9wjr1 261 64 in in IN cord-026384-ejk9wjr1 261 65 a a DT cord-026384-ejk9wjr1 261 66 population population NN cord-026384-ejk9wjr1 261 67 - - HYPH cord-026384-ejk9wjr1 261 68 based base VBN cord-026384-ejk9wjr1 261 69 cohort cohort NN cord-026384-ejk9wjr1 261 70 Parental parental JJ cord-026384-ejk9wjr1 261 71 perspectives perspective NNS cord-026384-ejk9wjr1 261 72 regarding regard VBG cord-026384-ejk9wjr1 261 73 outcomes outcome NNS cord-026384-ejk9wjr1 261 74 of of IN cord-026384-ejk9wjr1 261 75 very very RB cord-026384-ejk9wjr1 261 76 preterm preterm JJ cord-026384-ejk9wjr1 261 77 infants infant NNS cord-026384-ejk9wjr1 261 78 : : : cord-026384-ejk9wjr1 261 79 toward toward IN cord-026384-ejk9wjr1 261 80 a a DT cord-026384-ejk9wjr1 261 81 balanced balanced JJ cord-026384-ejk9wjr1 261 82 approach approach NN cord-026384-ejk9wjr1 261 83 Risk risk NN cord-026384-ejk9wjr1 261 84 of of IN cord-026384-ejk9wjr1 261 85 developmental developmental JJ cord-026384-ejk9wjr1 261 86 delay delay NN cord-026384-ejk9wjr1 261 87 increases increase VBZ cord-026384-ejk9wjr1 261 88 exponentially exponentially RB cord-026384-ejk9wjr1 261 89 as as IN cord-026384-ejk9wjr1 261 90 gestational gestational JJ cord-026384-ejk9wjr1 261 91 age age NN cord-026384-ejk9wjr1 261 92 of of IN cord-026384-ejk9wjr1 261 93 preterm preterm JJ cord-026384-ejk9wjr1 261 94 infants infant NNS cord-026384-ejk9wjr1 261 95 decreases decrease VBZ cord-026384-ejk9wjr1 261 96 : : : cord-026384-ejk9wjr1 261 97 a a DT cord-026384-ejk9wjr1 261 98 cohort cohort NN cord-026384-ejk9wjr1 261 99 study study NN cord-026384-ejk9wjr1 261 100 at at IN cord-026384-ejk9wjr1 261 101 age age NN cord-026384-ejk9wjr1 261 102 4 4 CD cord-026384-ejk9wjr1 261 103 years year NNS cord-026384-ejk9wjr1 262 1 Preterm Preterm NNP cord-026384-ejk9wjr1 262 2 birth birth NN cord-026384-ejk9wjr1 262 3 - - HYPH cord-026384-ejk9wjr1 262 4 associated associate VBN cord-026384-ejk9wjr1 262 5 neurodevelopmental neurodevelopmental JJ cord-026384-ejk9wjr1 262 6 impairment impairment NN cord-026384-ejk9wjr1 262 7 estimates estimate NNS cord-026384-ejk9wjr1 262 8 at at IN cord-026384-ejk9wjr1 262 9 regional regional JJ cord-026384-ejk9wjr1 262 10 and and CC cord-026384-ejk9wjr1 262 11 global global JJ cord-026384-ejk9wjr1 262 12 levels level NNS cord-026384-ejk9wjr1 262 13 for for IN cord-026384-ejk9wjr1 262 14 2010 2010 CD cord-026384-ejk9wjr1 262 15 Late late JJ cord-026384-ejk9wjr1 262 16 respiratory respiratory JJ cord-026384-ejk9wjr1 262 17 outcomes outcome NNS cord-026384-ejk9wjr1 262 18 after after IN cord-026384-ejk9wjr1 262 19 preterm preterm NNS cord-026384-ejk9wjr1 262 20 birth birth NN cord-026384-ejk9wjr1 262 21 Respiratory respiratory JJ cord-026384-ejk9wjr1 262 22 health health NN cord-026384-ejk9wjr1 262 23 in in IN cord-026384-ejk9wjr1 262 24 pre pre JJ cord-026384-ejk9wjr1 262 25 - - JJ cord-026384-ejk9wjr1 262 26 school school JJ cord-026384-ejk9wjr1 262 27 and and CC cord-026384-ejk9wjr1 262 28 school school NN cord-026384-ejk9wjr1 262 29 age age NN cord-026384-ejk9wjr1 262 30 children child NNS cord-026384-ejk9wjr1 262 31 following follow VBG cord-026384-ejk9wjr1 262 32 extremely extremely RB cord-026384-ejk9wjr1 262 33 preterm preterm JJR cord-026384-ejk9wjr1 262 34 birth birth NN cord-026384-ejk9wjr1 262 35 Preterm Preterm NNP cord-026384-ejk9wjr1 262 36 delivery delivery NN cord-026384-ejk9wjr1 262 37 and and CC cord-026384-ejk9wjr1 262 38 asthma asthma NN cord-026384-ejk9wjr1 262 39 : : : cord-026384-ejk9wjr1 262 40 a a DT cord-026384-ejk9wjr1 262 41 systematic systematic JJ cord-026384-ejk9wjr1 262 42 review review NN cord-026384-ejk9wjr1 262 43 and and CC cord-026384-ejk9wjr1 262 44 metaanalysis metaanalysis NN cord-026384-ejk9wjr1 262 45 Preterm Preterm NNP cord-026384-ejk9wjr1 262 46 birth birth NN cord-026384-ejk9wjr1 262 47 , , , cord-026384-ejk9wjr1 262 48 infant infant NN cord-026384-ejk9wjr1 262 49 weight weight NN cord-026384-ejk9wjr1 262 50 gain gain NN cord-026384-ejk9wjr1 262 51 , , , cord-026384-ejk9wjr1 262 52 and and CC cord-026384-ejk9wjr1 262 53 childhood childhood NN cord-026384-ejk9wjr1 262 54 asthma asthma NN cord-026384-ejk9wjr1 262 55 risk risk NN cord-026384-ejk9wjr1 262 56 : : : cord-026384-ejk9wjr1 262 57 a a DT cord-026384-ejk9wjr1 262 58 meta meta JJ cord-026384-ejk9wjr1 262 59 - - HYPH cord-026384-ejk9wjr1 262 60 analysis analysis NN cord-026384-ejk9wjr1 262 61 of of IN cord-026384-ejk9wjr1 262 62 147,000 147,000 CD cord-026384-ejk9wjr1 262 63 European european JJ cord-026384-ejk9wjr1 262 64 children child NNS cord-026384-ejk9wjr1 263 1 Preterm Preterm NNP cord-026384-ejk9wjr1 263 2 birth birth NN cord-026384-ejk9wjr1 263 3 : : : cord-026384-ejk9wjr1 263 4 risk risk NN cord-026384-ejk9wjr1 263 5 factor factor NN cord-026384-ejk9wjr1 263 6 for for IN cord-026384-ejk9wjr1 263 7 early early JJ cord-026384-ejk9wjr1 263 8 - - HYPH cord-026384-ejk9wjr1 263 9 onset onset NN cord-026384-ejk9wjr1 263 10 chronic chronic NN cord-026384-ejk9wjr1 263 11 diseases disease NNS cord-026384-ejk9wjr1 263 12 Preterm Preterm NNP cord-026384-ejk9wjr1 263 13 heart heart NN cord-026384-ejk9wjr1 263 14 in in IN cord-026384-ejk9wjr1 263 15 adult adult NN cord-026384-ejk9wjr1 263 16 life life NN cord-026384-ejk9wjr1 264 1 : : : cord-026384-ejk9wjr1 264 2 cardiovascular cardiovascular JJ cord-026384-ejk9wjr1 264 3 magnetic magnetic JJ cord-026384-ejk9wjr1 264 4 resonance resonance NN cord-026384-ejk9wjr1 264 5 reveals reveal VBZ cord-026384-ejk9wjr1 264 6 distinct distinct JJ cord-026384-ejk9wjr1 264 7 differences difference NNS cord-026384-ejk9wjr1 264 8 in in IN cord-026384-ejk9wjr1 264 9 left left JJ cord-026384-ejk9wjr1 264 10 ventricular ventricular JJ cord-026384-ejk9wjr1 264 11 mass mass NN cord-026384-ejk9wjr1 264 12 , , , cord-026384-ejk9wjr1 264 13 geometry geometry NN cord-026384-ejk9wjr1 264 14 , , , cord-026384-ejk9wjr1 264 15 and and CC cord-026384-ejk9wjr1 264 16 function function VB cord-026384-ejk9wjr1 264 17 Right right JJ cord-026384-ejk9wjr1 264 18 ventricular ventricular JJ cord-026384-ejk9wjr1 264 19 systolic systolic JJ cord-026384-ejk9wjr1 264 20 dysfunction dysfunction NN cord-026384-ejk9wjr1 264 21 in in IN cord-026384-ejk9wjr1 264 22 young young JJ cord-026384-ejk9wjr1 264 23 adults adult NNS cord-026384-ejk9wjr1 264 24 born bear VBD cord-026384-ejk9wjr1 264 25 preterm preterm JJ cord-026384-ejk9wjr1 264 26 Elevated elevated JJ cord-026384-ejk9wjr1 264 27 blood blood NN cord-026384-ejk9wjr1 264 28 pressure pressure NN cord-026384-ejk9wjr1 264 29 in in IN cord-026384-ejk9wjr1 264 30 preterm preterm NNS cord-026384-ejk9wjr1 264 31 - - HYPH cord-026384-ejk9wjr1 264 32 born bear VBN cord-026384-ejk9wjr1 264 33 offspring offspring NN cord-026384-ejk9wjr1 264 34 associates associate NNS cord-026384-ejk9wjr1 264 35 with with IN cord-026384-ejk9wjr1 264 36 a a DT cord-026384-ejk9wjr1 264 37 distinct distinct JJ cord-026384-ejk9wjr1 264 38 antiangiogenic antiangiogenic JJ cord-026384-ejk9wjr1 264 39 state state NN cord-026384-ejk9wjr1 264 40 and and CC cord-026384-ejk9wjr1 264 41 microvascular microvascular JJ cord-026384-ejk9wjr1 264 42 abnormalities abnormality NNS cord-026384-ejk9wjr1 264 43 in in IN cord-026384-ejk9wjr1 264 44 adult adult NN cord-026384-ejk9wjr1 264 45 life life NN cord-026384-ejk9wjr1 264 46 Preterm Preterm NNP cord-026384-ejk9wjr1 264 47 birth birth NN cord-026384-ejk9wjr1 264 48 and and CC cord-026384-ejk9wjr1 264 49 the the DT cord-026384-ejk9wjr1 264 50 metabolic metabolic JJ cord-026384-ejk9wjr1 264 51 syndrome syndrome NN cord-026384-ejk9wjr1 264 52 in in IN cord-026384-ejk9wjr1 264 53 adult adult NN cord-026384-ejk9wjr1 264 54 life life NN cord-026384-ejk9wjr1 264 55 : : : cord-026384-ejk9wjr1 264 56 a a DT cord-026384-ejk9wjr1 264 57 systematic systematic JJ cord-026384-ejk9wjr1 264 58 review review NN cord-026384-ejk9wjr1 264 59 and and CC cord-026384-ejk9wjr1 264 60 meta meta NN cord-026384-ejk9wjr1 264 61 - - HYPH cord-026384-ejk9wjr1 264 62 analysis analysis NN cord-026384-ejk9wjr1 264 63 Prevalence prevalence NN cord-026384-ejk9wjr1 264 64 of of IN cord-026384-ejk9wjr1 264 65 diabetes diabetes NN cord-026384-ejk9wjr1 264 66 and and CC cord-026384-ejk9wjr1 264 67 obesity obesity NN cord-026384-ejk9wjr1 264 68 in in IN cord-026384-ejk9wjr1 264 69 association association NN cord-026384-ejk9wjr1 264 70 with with IN cord-026384-ejk9wjr1 264 71 prematurity prematurity NN cord-026384-ejk9wjr1 264 72 and and CC cord-026384-ejk9wjr1 264 73 growth growth NN cord-026384-ejk9wjr1 264 74 restriction restriction NN cord-026384-ejk9wjr1 264 75 Prematurity prematurity NN cord-026384-ejk9wjr1 264 76 : : : cord-026384-ejk9wjr1 264 77 an an DT cord-026384-ejk9wjr1 264 78 overview overview NN cord-026384-ejk9wjr1 264 79 and and CC cord-026384-ejk9wjr1 264 80 public public JJ cord-026384-ejk9wjr1 264 81 health health NN cord-026384-ejk9wjr1 264 82 implications implication NNS cord-026384-ejk9wjr1 264 83 Measurement Measurement NNP cord-026384-ejk9wjr1 264 84 of of IN cord-026384-ejk9wjr1 264 85 quality quality NN cord-026384-ejk9wjr1 264 86 of of IN cord-026384-ejk9wjr1 264 87 life life NN cord-026384-ejk9wjr1 264 88 of of IN cord-026384-ejk9wjr1 264 89 survivors survivor NNS cord-026384-ejk9wjr1 264 90 of of IN cord-026384-ejk9wjr1 264 91 neonatal neonatal JJ cord-026384-ejk9wjr1 264 92 intensive intensive JJ cord-026384-ejk9wjr1 264 93 care care NN cord-026384-ejk9wjr1 264 94 : : : cord-026384-ejk9wjr1 264 95 critique critique NN cord-026384-ejk9wjr1 264 96 and and CC cord-026384-ejk9wjr1 264 97 implications implication NNS cord-026384-ejk9wjr1 264 98 Quality quality NN cord-026384-ejk9wjr1 264 99 of of IN cord-026384-ejk9wjr1 264 100 life life NN cord-026384-ejk9wjr1 264 101 assessment assessment NN cord-026384-ejk9wjr1 264 102 in in IN cord-026384-ejk9wjr1 264 103 preterm preterm JJR cord-026384-ejk9wjr1 264 104 children child NNS cord-026384-ejk9wjr1 264 105 : : : cord-026384-ejk9wjr1 264 106 physicians physician NNS cord-026384-ejk9wjr1 264 107 ' ' POS cord-026384-ejk9wjr1 264 108 knowledge knowledge NN cord-026384-ejk9wjr1 264 109 , , , cord-026384-ejk9wjr1 264 110 attitude attitude NN cord-026384-ejk9wjr1 264 111 , , , cord-026384-ejk9wjr1 264 112 belief belief NN cord-026384-ejk9wjr1 264 113 , , , cord-026384-ejk9wjr1 264 114 practice practice NN cord-026384-ejk9wjr1 264 115 -a -a : cord-026384-ejk9wjr1 264 116 KABP KABP NNP cord-026384-ejk9wjr1 264 117 study study NN cord-026384-ejk9wjr1 264 118 Health Health NNP cord-026384-ejk9wjr1 264 119 - - HYPH cord-026384-ejk9wjr1 264 120 related relate VBN cord-026384-ejk9wjr1 264 121 quality quality NN cord-026384-ejk9wjr1 264 122 of of IN cord-026384-ejk9wjr1 264 123 life life NN cord-026384-ejk9wjr1 264 124 and and CC cord-026384-ejk9wjr1 264 125 emotional emotional JJ cord-026384-ejk9wjr1 264 126 and and CC cord-026384-ejk9wjr1 264 127 behavioral behavioral JJ cord-026384-ejk9wjr1 264 128 difficulties difficulty NNS cord-026384-ejk9wjr1 264 129 after after IN cord-026384-ejk9wjr1 264 130 extreme extreme JJ cord-026384-ejk9wjr1 264 131 preterm preterm JJR cord-026384-ejk9wjr1 264 132 birth birth NN cord-026384-ejk9wjr1 264 133 : : : cord-026384-ejk9wjr1 264 134 developmental developmental JJ cord-026384-ejk9wjr1 264 135 trajectories trajectory NNS cord-026384-ejk9wjr1 265 1 Prognostic prognostic JJ cord-026384-ejk9wjr1 265 2 factors factor NNS cord-026384-ejk9wjr1 265 3 for for IN cord-026384-ejk9wjr1 265 4 poor poor JJ cord-026384-ejk9wjr1 265 5 cognitive cognitive JJ cord-026384-ejk9wjr1 265 6 development development NN cord-026384-ejk9wjr1 265 7 in in IN cord-026384-ejk9wjr1 265 8 children child NNS cord-026384-ejk9wjr1 265 9 born bear VBD cord-026384-ejk9wjr1 265 10 very very RB cord-026384-ejk9wjr1 265 11 preterm preterm NNS cord-026384-ejk9wjr1 265 12 or or CC cord-026384-ejk9wjr1 265 13 with with IN cord-026384-ejk9wjr1 265 14 very very RB cord-026384-ejk9wjr1 265 15 low low JJ cord-026384-ejk9wjr1 265 16 birth birth NN cord-026384-ejk9wjr1 265 17 weight weight NN cord-026384-ejk9wjr1 265 18 : : : cord-026384-ejk9wjr1 265 19 a a DT cord-026384-ejk9wjr1 265 20 systematic systematic JJ cord-026384-ejk9wjr1 265 21 review review NN cord-026384-ejk9wjr1 266 1 Prognostic prognostic JJ cord-026384-ejk9wjr1 266 2 factors factor NNS cord-026384-ejk9wjr1 266 3 for for IN cord-026384-ejk9wjr1 266 4 cerebral cerebral JJ cord-026384-ejk9wjr1 266 5 palsy palsy JJ cord-026384-ejk9wjr1 266 6 and and CC cord-026384-ejk9wjr1 266 7 motor motor NN cord-026384-ejk9wjr1 266 8 impairment impairment NN cord-026384-ejk9wjr1 266 9 in in IN cord-026384-ejk9wjr1 266 10 children child NNS cord-026384-ejk9wjr1 266 11 born bear VBD cord-026384-ejk9wjr1 266 12 very very RB cord-026384-ejk9wjr1 266 13 preterm preterm NNS cord-026384-ejk9wjr1 266 14 or or CC cord-026384-ejk9wjr1 266 15 very very RB cord-026384-ejk9wjr1 266 16 low low JJ cord-026384-ejk9wjr1 266 17 birthweight birthweight NN cord-026384-ejk9wjr1 266 18 : : : cord-026384-ejk9wjr1 266 19 a a DT cord-026384-ejk9wjr1 266 20 systematic systematic JJ cord-026384-ejk9wjr1 266 21 review review NN cord-026384-ejk9wjr1 266 22 Evidence evidence NN cord-026384-ejk9wjr1 266 23 for for IN cord-026384-ejk9wjr1 266 24 catchup catchup NN cord-026384-ejk9wjr1 266 25 in in IN cord-026384-ejk9wjr1 266 26 cognition cognition NN cord-026384-ejk9wjr1 266 27 and and CC cord-026384-ejk9wjr1 266 28 receptive receptive JJ cord-026384-ejk9wjr1 266 29 vocabulary vocabulary NN cord-026384-ejk9wjr1 266 30 among among IN cord-026384-ejk9wjr1 266 31 adolescents adolescent NNS cord-026384-ejk9wjr1 266 32 born bear VBN cord-026384-ejk9wjr1 266 33 very very RB cord-026384-ejk9wjr1 266 34 preterm preterm RB cord-026384-ejk9wjr1 267 1 The the DT cord-026384-ejk9wjr1 267 2 economic economic JJ cord-026384-ejk9wjr1 267 3 burden burden NN cord-026384-ejk9wjr1 267 4 of of IN cord-026384-ejk9wjr1 267 5 prematurity prematurity NN cord-026384-ejk9wjr1 267 6 in in IN cord-026384-ejk9wjr1 267 7 Canada Canada NNP cord-026384-ejk9wjr1 267 8 Changing change VBG cord-026384-ejk9wjr1 267 9 definitions definition NNS cord-026384-ejk9wjr1 267 10 of of IN cord-026384-ejk9wjr1 267 11 long long JJ cord-026384-ejk9wjr1 267 12 - - HYPH cord-026384-ejk9wjr1 267 13 term term NN cord-026384-ejk9wjr1 267 14 followup followup NN cord-026384-ejk9wjr1 267 15 : : : cord-026384-ejk9wjr1 267 16 should should MD cord-026384-ejk9wjr1 267 17 " " `` cord-026384-ejk9wjr1 267 18 long long JJ cord-026384-ejk9wjr1 267 19 term term NN cord-026384-ejk9wjr1 267 20 " " '' cord-026384-ejk9wjr1 267 21 be be VB cord-026384-ejk9wjr1 267 22 even even RB cord-026384-ejk9wjr1 267 23 longer long JJR cord-026384-ejk9wjr1 267 24 ? ? . cord-026384-ejk9wjr1 268 1 Functional functional JJ cord-026384-ejk9wjr1 268 2 outcomes outcome NNS cord-026384-ejk9wjr1 268 3 of of IN cord-026384-ejk9wjr1 268 4 very very RB cord-026384-ejk9wjr1 268 5 premature premature JJ cord-026384-ejk9wjr1 268 6 infants infant NNS cord-026384-ejk9wjr1 268 7 into into IN cord-026384-ejk9wjr1 268 8 adulthood adulthood NN cord-026384-ejk9wjr1 268 9 Social social JJ cord-026384-ejk9wjr1 268 10 competence competence NN cord-026384-ejk9wjr1 268 11 of of IN cord-026384-ejk9wjr1 268 12 preschool preschool NN cord-026384-ejk9wjr1 268 13 children child NNS cord-026384-ejk9wjr1 268 14 born bear VBD cord-026384-ejk9wjr1 268 15 very very RB cord-026384-ejk9wjr1 268 16 preterm preterm JJR cord-026384-ejk9wjr1 268 17 Prediction Prediction NNP cord-026384-ejk9wjr1 268 18 of of IN cord-026384-ejk9wjr1 268 19 cognitive cognitive JJ cord-026384-ejk9wjr1 268 20 abilities ability NNS cord-026384-ejk9wjr1 268 21 at at IN cord-026384-ejk9wjr1 268 22 the the DT cord-026384-ejk9wjr1 268 23 age age NN cord-026384-ejk9wjr1 268 24 of of IN cord-026384-ejk9wjr1 268 25 5 5 CD cord-026384-ejk9wjr1 268 26 years year NNS cord-026384-ejk9wjr1 268 27 using use VBG cord-026384-ejk9wjr1 268 28 developmental developmental JJ cord-026384-ejk9wjr1 268 29 follow follow NN cord-026384-ejk9wjr1 268 30 - - HYPH cord-026384-ejk9wjr1 268 31 up up RP cord-026384-ejk9wjr1 268 32 assessments assessment NNS cord-026384-ejk9wjr1 268 33 at at IN cord-026384-ejk9wjr1 268 34 the the DT cord-026384-ejk9wjr1 268 35 age age NN cord-026384-ejk9wjr1 268 36 of of IN cord-026384-ejk9wjr1 268 37 2 2 CD cord-026384-ejk9wjr1 268 38 and and CC cord-026384-ejk9wjr1 268 39 3 3 CD cord-026384-ejk9wjr1 268 40 years year NNS cord-026384-ejk9wjr1 268 41 in in IN cord-026384-ejk9wjr1 268 42 very very RB cord-026384-ejk9wjr1 268 43 preterm preterm JJR cord-026384-ejk9wjr1 268 44 children child NNS cord-026384-ejk9wjr1 268 45 Predicting predict VBG cord-026384-ejk9wjr1 268 46 the the DT cord-026384-ejk9wjr1 268 47 outcomes outcome NNS cord-026384-ejk9wjr1 268 48 of of IN cord-026384-ejk9wjr1 268 49 preterm preterm JJ cord-026384-ejk9wjr1 268 50 neonates neonate NNS cord-026384-ejk9wjr1 268 51 beyond beyond IN cord-026384-ejk9wjr1 268 52 the the DT cord-026384-ejk9wjr1 268 53 neonatal neonatal JJ cord-026384-ejk9wjr1 268 54 intensive intensive JJ cord-026384-ejk9wjr1 268 55 Perinatal perinatal JJ cord-026384-ejk9wjr1 268 56 risk risk NN cord-026384-ejk9wjr1 268 57 factors factor NNS cord-026384-ejk9wjr1 268 58 of of IN cord-026384-ejk9wjr1 268 59 adverse adverse JJ cord-026384-ejk9wjr1 268 60 outcome outcome NN cord-026384-ejk9wjr1 268 61 in in IN cord-026384-ejk9wjr1 268 62 very very RB cord-026384-ejk9wjr1 268 63 preterm preterm JJR cord-026384-ejk9wjr1 268 64 children child NNS cord-026384-ejk9wjr1 268 65 : : : cord-026384-ejk9wjr1 268 66 a a DT cord-026384-ejk9wjr1 268 67 role role NN cord-026384-ejk9wjr1 268 68 of of IN cord-026384-ejk9wjr1 268 69 initial initial JJ cord-026384-ejk9wjr1 268 70 treatment treatment NN cord-026384-ejk9wjr1 268 71 of of IN cord-026384-ejk9wjr1 268 72 respiratory respiratory JJ cord-026384-ejk9wjr1 268 73 insufficiency insufficiency NN cord-026384-ejk9wjr1 268 74 ? ? . cord-026384-ejk9wjr1 269 1 The the DT cord-026384-ejk9wjr1 269 2 relationship relationship NN cord-026384-ejk9wjr1 269 3 between between IN cord-026384-ejk9wjr1 269 4 behavior behavior NN cord-026384-ejk9wjr1 269 5 ratings rating NNS cord-026384-ejk9wjr1 269 6 and and CC cord-026384-ejk9wjr1 269 7 concurrent concurrent JJ cord-026384-ejk9wjr1 269 8 and and CC cord-026384-ejk9wjr1 269 9 subsequent subsequent JJ cord-026384-ejk9wjr1 269 10 mental mental JJ cord-026384-ejk9wjr1 269 11 and and CC cord-026384-ejk9wjr1 269 12 motor motor NN cord-026384-ejk9wjr1 269 13 performance performance NN cord-026384-ejk9wjr1 269 14 in in IN cord-026384-ejk9wjr1 269 15 toddlers toddler NNS cord-026384-ejk9wjr1 269 16 born bear VBN cord-026384-ejk9wjr1 269 17 at at IN cord-026384-ejk9wjr1 269 18 extremely extremely RB cord-026384-ejk9wjr1 269 19 low low JJ cord-026384-ejk9wjr1 269 20 birth birth NN cord-026384-ejk9wjr1 269 21 weight weight NN cord-026384-ejk9wjr1 270 1 Prognostic prognostic JJ cord-026384-ejk9wjr1 270 2 factors factor NNS cord-026384-ejk9wjr1 270 3 for for IN cord-026384-ejk9wjr1 270 4 behavioral behavioral JJ cord-026384-ejk9wjr1 270 5 problems problem NNS cord-026384-ejk9wjr1 270 6 and and CC cord-026384-ejk9wjr1 270 7 psychiatric psychiatric JJ cord-026384-ejk9wjr1 270 8 disorders disorder NNS cord-026384-ejk9wjr1 270 9 in in IN cord-026384-ejk9wjr1 270 10 children child NNS cord-026384-ejk9wjr1 270 11 born bear VBD cord-026384-ejk9wjr1 270 12 very very RB cord-026384-ejk9wjr1 270 13 preterm preterm NNS cord-026384-ejk9wjr1 270 14 or or CC cord-026384-ejk9wjr1 270 15 very very RB cord-026384-ejk9wjr1 270 16 low low JJ cord-026384-ejk9wjr1 270 17 birth birth NN cord-026384-ejk9wjr1 270 18 weight weight NN cord-026384-ejk9wjr1 270 19 : : : cord-026384-ejk9wjr1 270 20 a a DT cord-026384-ejk9wjr1 270 21 systematic systematic JJ cord-026384-ejk9wjr1 270 22 review review NN cord-026384-ejk9wjr1 270 23 Neurodevelopmental Neurodevelopmental NNP cord-026384-ejk9wjr1 270 24 outcomes outcome NNS cord-026384-ejk9wjr1 270 25 of of IN cord-026384-ejk9wjr1 270 26 extremely extremely RB cord-026384-ejk9wjr1 270 27 low low JJ cord-026384-ejk9wjr1 270 28 birth birth NN cord-026384-ejk9wjr1 270 29 weight weight NN cord-026384-ejk9wjr1 270 30 infants infant NNS cord-026384-ejk9wjr1 271 1 < < XX cord-026384-ejk9wjr1 271 2 32 32 CD cord-026384-ejk9wjr1 271 3 weeks week NNS cord-026384-ejk9wjr1 271 4 ' ' POS cord-026384-ejk9wjr1 271 5 gestation gestation NN cord-026384-ejk9wjr1 271 6 between between IN cord-026384-ejk9wjr1 271 7 Neighborhood Neighborhood NNP cord-026384-ejk9wjr1 271 8 influences influence NNS cord-026384-ejk9wjr1 271 9 on on IN cord-026384-ejk9wjr1 271 10 the the DT cord-026384-ejk9wjr1 271 11 academic academic JJ cord-026384-ejk9wjr1 271 12 achievement achievement NN cord-026384-ejk9wjr1 271 13 of of IN cord-026384-ejk9wjr1 271 14 extremely extremely RB cord-026384-ejk9wjr1 271 15 low low JJ cord-026384-ejk9wjr1 271 16 birth birth NN cord-026384-ejk9wjr1 271 17 weight weight NN cord-026384-ejk9wjr1 271 18 children child NNS cord-026384-ejk9wjr1 271 19 Mental mental JJ cord-026384-ejk9wjr1 271 20 health health NN cord-026384-ejk9wjr1 271 21 outcomes outcome NNS cord-026384-ejk9wjr1 271 22 in in IN cord-026384-ejk9wjr1 271 23 US US NNP cord-026384-ejk9wjr1 271 24 children child NNS cord-026384-ejk9wjr1 271 25 and and CC cord-026384-ejk9wjr1 271 26 adolescents adolescent NNS cord-026384-ejk9wjr1 271 27 born bear VBN cord-026384-ejk9wjr1 271 28 prematurely prematurely RB cord-026384-ejk9wjr1 271 29 or or CC cord-026384-ejk9wjr1 271 30 with with IN cord-026384-ejk9wjr1 271 31 low low JJ cord-026384-ejk9wjr1 271 32 birthweight birthweight JJ cord-026384-ejk9wjr1 271 33 Measurement Measurement NNP cord-026384-ejk9wjr1 271 34 of of IN cord-026384-ejk9wjr1 271 35 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 271 36 status status NN cord-026384-ejk9wjr1 271 37 in in IN cord-026384-ejk9wjr1 271 38 health health NN cord-026384-ejk9wjr1 271 39 disparities disparity NNS cord-026384-ejk9wjr1 271 40 research research NN cord-026384-ejk9wjr1 271 41 Family Family NNP cord-026384-ejk9wjr1 271 42 income income NN cord-026384-ejk9wjr1 271 43 trajectory trajectory NN cord-026384-ejk9wjr1 271 44 during during IN cord-026384-ejk9wjr1 271 45 childhood childhood NN cord-026384-ejk9wjr1 271 46 is be VBZ cord-026384-ejk9wjr1 271 47 associated associate VBN cord-026384-ejk9wjr1 271 48 with with IN cord-026384-ejk9wjr1 271 49 adiposity adiposity NN cord-026384-ejk9wjr1 271 50 in in IN cord-026384-ejk9wjr1 271 51 adolescence adolescence NN cord-026384-ejk9wjr1 271 52 : : : cord-026384-ejk9wjr1 271 53 a a DT cord-026384-ejk9wjr1 271 54 latent latent JJ cord-026384-ejk9wjr1 271 55 class class NN cord-026384-ejk9wjr1 271 56 growth growth NN cord-026384-ejk9wjr1 271 57 analysis analysis NN cord-026384-ejk9wjr1 271 58 Family Family NNP cord-026384-ejk9wjr1 271 59 income income NN cord-026384-ejk9wjr1 271 60 trajectory trajectory NN cord-026384-ejk9wjr1 271 61 during during IN cord-026384-ejk9wjr1 271 62 childhood childhood NN cord-026384-ejk9wjr1 271 63 is be VBZ cord-026384-ejk9wjr1 271 64 associated associate VBN cord-026384-ejk9wjr1 271 65 with with IN cord-026384-ejk9wjr1 271 66 adolescent adolescent JJ cord-026384-ejk9wjr1 271 67 cigarette cigarette NN cord-026384-ejk9wjr1 271 68 smoking smoking NN cord-026384-ejk9wjr1 271 69 and and CC cord-026384-ejk9wjr1 271 70 alcohol alcohol NN cord-026384-ejk9wjr1 271 71 use use NN cord-026384-ejk9wjr1 271 72 Machine machine NN cord-026384-ejk9wjr1 271 73 learning learn VBG cord-026384-ejk9wjr1 271 74 in in IN cord-026384-ejk9wjr1 271 75 medicine medicine NN cord-026384-ejk9wjr1 271 76 : : : cord-026384-ejk9wjr1 271 77 a a DT cord-026384-ejk9wjr1 271 78 primer primer NN cord-026384-ejk9wjr1 271 79 for for IN cord-026384-ejk9wjr1 271 80 physicians physician NNS cord-026384-ejk9wjr1 271 81 Predicting predict VBG cord-026384-ejk9wjr1 271 82 discharge discharge NN cord-026384-ejk9wjr1 271 83 dates date NNS cord-026384-ejk9wjr1 271 84 from from IN cord-026384-ejk9wjr1 271 85 the the DT cord-026384-ejk9wjr1 271 86 NICU NICU NNP cord-026384-ejk9wjr1 271 87 using use VBG cord-026384-ejk9wjr1 271 88 progress progress NN cord-026384-ejk9wjr1 271 89 note note NN cord-026384-ejk9wjr1 271 90 data datum NNS cord-026384-ejk9wjr1 272 1 A a DT cord-026384-ejk9wjr1 272 2 Life Life NNP cord-026384-ejk9wjr1 272 3 Course Course NNP cord-026384-ejk9wjr1 272 4 Approach Approach NNP cord-026384-ejk9wjr1 272 5 to to IN cord-026384-ejk9wjr1 272 6 Chronic Chronic NNP cord-026384-ejk9wjr1 272 7 Diseases Diseases NNPS cord-026384-ejk9wjr1 272 8 Epidemiology epidemiology NN cord-026384-ejk9wjr1 272 9 2nd 2nd NN cord-026384-ejk9wjr1 272 10 edn edn NN cord-026384-ejk9wjr1 272 11 . . . cord-026384-ejk9wjr1 273 1 A a DT cord-026384-ejk9wjr1 273 2 Life Life NNP cord-026384-ejk9wjr1 273 3 Course Course NNP cord-026384-ejk9wjr1 273 4 Approach Approach NNP cord-026384-ejk9wjr1 273 5 to to IN cord-026384-ejk9wjr1 273 6 Adult adult NN cord-026384-ejk9wjr1 273 7 health health NN cord-026384-ejk9wjr1 273 8 Scientists scientist NNS cord-026384-ejk9wjr1 273 9 rise rise VBP cord-026384-ejk9wjr1 273 10 up up RP cord-026384-ejk9wjr1 273 11 against against IN cord-026384-ejk9wjr1 273 12 statistical statistical JJ cord-026384-ejk9wjr1 273 13 significance significance NN cord-026384-ejk9wjr1 273 14 The the DT cord-026384-ejk9wjr1 273 15 ASA ASA NNP cord-026384-ejk9wjr1 273 16 's 's POS cord-026384-ejk9wjr1 273 17 Statement statement NN cord-026384-ejk9wjr1 273 18 on on IN cord-026384-ejk9wjr1 273 19 p p NN cord-026384-ejk9wjr1 273 20 - - HYPH cord-026384-ejk9wjr1 273 21 values value NNS cord-026384-ejk9wjr1 273 22 : : : cord-026384-ejk9wjr1 273 23 context context NN cord-026384-ejk9wjr1 273 24 , , , cord-026384-ejk9wjr1 273 25 process process NN cord-026384-ejk9wjr1 273 26 , , , cord-026384-ejk9wjr1 273 27 and and CC cord-026384-ejk9wjr1 273 28 purpose purpose NN cord-026384-ejk9wjr1 273 29 Time time NN cord-026384-ejk9wjr1 273 30 for for IN cord-026384-ejk9wjr1 273 31 clinicians clinician NNS cord-026384-ejk9wjr1 273 32 to to TO cord-026384-ejk9wjr1 273 33 embrace embrace VB cord-026384-ejk9wjr1 273 34 their -PRON- PRP$ cord-026384-ejk9wjr1 273 35 inner inner JJ cord-026384-ejk9wjr1 273 36 Bayesian Bayesian NNP cord-026384-ejk9wjr1 273 37 ? ? . cord-026384-ejk9wjr1 274 1 Reanalysis reanalysis NN cord-026384-ejk9wjr1 274 2 of of IN cord-026384-ejk9wjr1 274 3 results result NNS cord-026384-ejk9wjr1 274 4 of of IN cord-026384-ejk9wjr1 274 5 a a DT cord-026384-ejk9wjr1 274 6 clinical clinical JJ cord-026384-ejk9wjr1 274 7 trial trial NN cord-026384-ejk9wjr1 274 8 of of IN cord-026384-ejk9wjr1 274 9 extracorporeal extracorporeal JJ cord-026384-ejk9wjr1 274 10 membrane membrane NN cord-026384-ejk9wjr1 274 11 oxygenation oxygenation NN cord-026384-ejk9wjr1 274 12 Semi Semi NNP cord-026384-ejk9wjr1 274 13 - - JJ cord-026384-ejk9wjr1 274 14 competing compete VBG cord-026384-ejk9wjr1 274 15 risks risk NNS cord-026384-ejk9wjr1 274 16 data datum NNS cord-026384-ejk9wjr1 274 17 analysis analysis NN cord-026384-ejk9wjr1 274 18 : : : cord-026384-ejk9wjr1 274 19 accounting account VBG cord-026384-ejk9wjr1 274 20 for for IN cord-026384-ejk9wjr1 274 21 death death NN cord-026384-ejk9wjr1 274 22 as as IN cord-026384-ejk9wjr1 274 23 a a DT cord-026384-ejk9wjr1 274 24 competing compete VBG cord-026384-ejk9wjr1 274 25 risk risk NN cord-026384-ejk9wjr1 274 26 when when WRB cord-026384-ejk9wjr1 274 27 the the DT cord-026384-ejk9wjr1 274 28 outcome outcome NN cord-026384-ejk9wjr1 274 29 of of IN cord-026384-ejk9wjr1 274 30 interest interest NN cord-026384-ejk9wjr1 274 31 is be VBZ cord-026384-ejk9wjr1 274 32 nonterminal nonterminal NNP cord-026384-ejk9wjr1 274 33 Beyond Beyond NNP cord-026384-ejk9wjr1 274 34 composite composite JJ cord-026384-ejk9wjr1 274 35 endpoints endpoint NNS cord-026384-ejk9wjr1 274 36 analysis analysis NN cord-026384-ejk9wjr1 274 37 : : : cord-026384-ejk9wjr1 274 38 semicompeting semicompeting NN cord-026384-ejk9wjr1 274 39 risks risk NNS cord-026384-ejk9wjr1 274 40 as as IN cord-026384-ejk9wjr1 274 41 an an DT cord-026384-ejk9wjr1 274 42 underutilized underutilized JJ cord-026384-ejk9wjr1 274 43 framework framework NN cord-026384-ejk9wjr1 274 44 for for IN cord-026384-ejk9wjr1 274 45 cancer cancer NN cord-026384-ejk9wjr1 274 46 research research NN cord-026384-ejk9wjr1 274 47 Use use NN cord-026384-ejk9wjr1 274 48 and and CC cord-026384-ejk9wjr1 274 49 misuse misuse NN cord-026384-ejk9wjr1 274 50 of of IN cord-026384-ejk9wjr1 274 51 the the DT cord-026384-ejk9wjr1 274 52 receiver receiver NN cord-026384-ejk9wjr1 274 53 operating operate VBG cord-026384-ejk9wjr1 274 54 characteristic characteristic JJ cord-026384-ejk9wjr1 274 55 curve curve NN cord-026384-ejk9wjr1 274 56 in in IN cord-026384-ejk9wjr1 274 57 risk risk NN cord-026384-ejk9wjr1 274 58 prediction prediction NN cord-026384-ejk9wjr1 274 59 Assessing assess VBG cord-026384-ejk9wjr1 274 60 the the DT cord-026384-ejk9wjr1 274 61 performance performance NN cord-026384-ejk9wjr1 274 62 of of IN cord-026384-ejk9wjr1 274 63 prediction prediction NN cord-026384-ejk9wjr1 274 64 models model NNS cord-026384-ejk9wjr1 274 65 : : : cord-026384-ejk9wjr1 274 66 a a DT cord-026384-ejk9wjr1 274 67 framework framework NN cord-026384-ejk9wjr1 274 68 for for IN cord-026384-ejk9wjr1 274 69 traditional traditional JJ cord-026384-ejk9wjr1 274 70 and and CC cord-026384-ejk9wjr1 274 71 novel novel JJ cord-026384-ejk9wjr1 274 72 measures measure NNS cord-026384-ejk9wjr1 274 73 Novel novel JJ cord-026384-ejk9wjr1 274 74 metrics metric NNS cord-026384-ejk9wjr1 274 75 for for IN cord-026384-ejk9wjr1 274 76 evaluating evaluate VBG cord-026384-ejk9wjr1 274 77 improvement improvement NN cord-026384-ejk9wjr1 274 78 in in IN cord-026384-ejk9wjr1 274 79 discrimination discrimination NN cord-026384-ejk9wjr1 274 80 : : : cord-026384-ejk9wjr1 274 81 net net JJ cord-026384-ejk9wjr1 274 82 reclassification reclassification NN cord-026384-ejk9wjr1 274 83 and and CC cord-026384-ejk9wjr1 274 84 integrated integrated JJ cord-026384-ejk9wjr1 274 85 discrimination discrimination NN cord-026384-ejk9wjr1 274 86 improvement improvement NN cord-026384-ejk9wjr1 274 87 for for IN cord-026384-ejk9wjr1 274 88 normal normal JJ cord-026384-ejk9wjr1 274 89 variables variable NNS cord-026384-ejk9wjr1 274 90 and and CC cord-026384-ejk9wjr1 274 91 nested nested JJ cord-026384-ejk9wjr1 274 92 models model NNS cord-026384-ejk9wjr1 275 1 Multivariable multivariable JJ cord-026384-ejk9wjr1 275 2 prognostic prognostic JJ cord-026384-ejk9wjr1 275 3 models model NNS cord-026384-ejk9wjr1 275 4 : : : cord-026384-ejk9wjr1 275 5 issues issue NNS cord-026384-ejk9wjr1 275 6 in in IN cord-026384-ejk9wjr1 275 7 developing develop VBG cord-026384-ejk9wjr1 275 8 models model NNS cord-026384-ejk9wjr1 275 9 , , , cord-026384-ejk9wjr1 275 10 evaluating evaluate VBG cord-026384-ejk9wjr1 275 11 assumptions assumption NNS cord-026384-ejk9wjr1 275 12 and and CC cord-026384-ejk9wjr1 275 13 adequacy adequacy NN cord-026384-ejk9wjr1 275 14 , , , cord-026384-ejk9wjr1 275 15 and and CC cord-026384-ejk9wjr1 275 16 measuring measure VBG cord-026384-ejk9wjr1 275 17 and and CC cord-026384-ejk9wjr1 275 18 reducing reduce VBG cord-026384-ejk9wjr1 275 19 errors error NNS cord-026384-ejk9wjr1 275 20 Limitations limitation NNS cord-026384-ejk9wjr1 275 21 of of IN cord-026384-ejk9wjr1 275 22 the the DT cord-026384-ejk9wjr1 275 23 odds odd NNS cord-026384-ejk9wjr1 275 24 ratio ratio NN cord-026384-ejk9wjr1 275 25 in in IN cord-026384-ejk9wjr1 275 26 gauging gauge VBG cord-026384-ejk9wjr1 275 27 the the DT cord-026384-ejk9wjr1 275 28 performance performance NN cord-026384-ejk9wjr1 275 29 of of IN cord-026384-ejk9wjr1 275 30 a a DT cord-026384-ejk9wjr1 275 31 diagnostic diagnostic JJ cord-026384-ejk9wjr1 275 32 , , , cord-026384-ejk9wjr1 275 33 prognostic prognostic JJ cord-026384-ejk9wjr1 275 34 , , , cord-026384-ejk9wjr1 275 35 or or CC cord-026384-ejk9wjr1 275 36 screening screening NN cord-026384-ejk9wjr1 275 37 marker marker NN cord-026384-ejk9wjr1 276 1 Just just RB cord-026384-ejk9wjr1 276 2 health health NN cord-026384-ejk9wjr1 276 3 : : : cord-026384-ejk9wjr1 276 4 on on IN cord-026384-ejk9wjr1 276 5 the the DT cord-026384-ejk9wjr1 276 6 conditions condition NNS cord-026384-ejk9wjr1 276 7 for for IN cord-026384-ejk9wjr1 276 8 acceptable acceptable JJ cord-026384-ejk9wjr1 276 9 and and CC cord-026384-ejk9wjr1 276 10 unacceptable unacceptable JJ cord-026384-ejk9wjr1 276 11 priority priority NN cord-026384-ejk9wjr1 276 12 settings setting NNS cord-026384-ejk9wjr1 276 13 with with IN cord-026384-ejk9wjr1 276 14 respect respect NN cord-026384-ejk9wjr1 276 15 to to IN cord-026384-ejk9wjr1 276 16 patients patient NNS cord-026384-ejk9wjr1 276 17 ' ' POS cord-026384-ejk9wjr1 276 18 socioeconomic socioeconomic JJ cord-026384-ejk9wjr1 276 19 status status NN cord-026384-ejk9wjr1 276 20 AUC auc NN cord-026384-ejk9wjr1 276 21 : : : cord-026384-ejk9wjr1 276 22 0.703 0.703 CD cord-026384-ejk9wjr1 276 23 Sensitivity sensitivity NN cord-026384-ejk9wjr1 276 24 : : : cord-026384-ejk9wjr1 276 25 27.6 27.6 CD cord-026384-ejk9wjr1 276 26 % % NN cord-026384-ejk9wjr1 276 27 Specificity specificity NN cord-026384-ejk9wjr1 276 28 : : : cord-026384-ejk9wjr1 276 29 87.3 87.3 CD cord-026384-ejk9wjr1 276 30 % % NN cord-026384-ejk9wjr1 276 31 Competing Competing NNP cord-026384-ejk9wjr1 276 32 interests interest NNS cord-026384-ejk9wjr1 276 33 : : : cord-026384-ejk9wjr1 277 1 The the DT cord-026384-ejk9wjr1 277 2 authors author NNS cord-026384-ejk9wjr1 277 3 declare declare VBP cord-026384-ejk9wjr1 277 4 no no DT cord-026384-ejk9wjr1 277 5 competing compete VBG cord-026384-ejk9wjr1 277 6 interests interest NNS cord-026384-ejk9wjr1 277 7 . . . cord-026384-ejk9wjr1 278 1 Publisher publisher NN cord-026384-ejk9wjr1 278 2 's 's POS cord-026384-ejk9wjr1 278 3 note note NN cord-026384-ejk9wjr1 278 4 Springer Springer NNP cord-026384-ejk9wjr1 278 5 Nature Nature NNP cord-026384-ejk9wjr1 278 6 remains remain VBZ cord-026384-ejk9wjr1 278 7 neutral neutral JJ cord-026384-ejk9wjr1 278 8 with with IN cord-026384-ejk9wjr1 278 9 regard regard NN cord-026384-ejk9wjr1 278 10 to to IN cord-026384-ejk9wjr1 278 11 jurisdictional jurisdictional JJ cord-026384-ejk9wjr1 278 12 claims claim NNS cord-026384-ejk9wjr1 278 13 in in IN cord-026384-ejk9wjr1 278 14 published publish VBN cord-026384-ejk9wjr1 278 15 maps map NNS cord-026384-ejk9wjr1 278 16 and and CC cord-026384-ejk9wjr1 278 17 institutional institutional JJ cord-026384-ejk9wjr1 278 18 affiliations affiliation NNS cord-026384-ejk9wjr1 278 19 . . .