id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-035287-l6trtvil	Kanno, Takeshi	Who Needs Gastroprotection in 2020?	2020-11-11		.txt	text/plain	7651	325	43	pylori eradication, PPI therapy, COX-2 inhibition, and prostaglandin analogues in preventing peptic ulcer bleeding and focus on which high-risk groups these approaches could be recommended. This excess could be related to bias and confounding factors inherent with database studies, but a systematic review [26] of RCTs supported this finding, and patients on dual antiplatelet therapy had almost twice the rate of gastrointestinal bleeding compared to those taking ASA alone. pylori as the same systematic review [56] found an approximately four-fold increased risk of developing peptic ulcer bleeding in those taking NSAIDS and a 6-fold increase in patients where both factors were present. Clinical data support this hypothesis with a systematic review [85] of 18 RCTs involving over 10,000 participants demonstrating that PPIs reduced PUD bleeds by approximately 80% compared to controls although the effect was less marked in patients who were already taking NSAID therapy long term.	./cache/cord-035287-l6trtvil.txt	./txt/cord-035287-l6trtvil.txt