id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011701-toevn37u	Venkatesan, Sudhir	Antiviral treatment for outpatient use during an influenza pandemic: a decision tree model of outcomes averted and cost-effectiveness	2018-06-28		.txt	text/plain	4204	207	41	METHODS: We developed a spreadsheet-based, decision tree model to assess outcomes averted and cost-effectiveness of antiviral treatment for outpatient use from the perspective of the healthcare payer in the UK. CONCLUSIONS: This analysis shows that across pandemic scenarios, antiviral treatment can be cost-saving for population groups at high risk of influenza-related complications. [15] [16] [17] Two meta-analyses of the extant clinical trial data, examining outcomes based on the intention-to-treat-influenza infected (ITTI) approach, found that early NAI treatment (≤48 h of symptom onset) was associated with a risk reduction of 59 18 and 63% 19 for hospital admission in otherwise healthy patients with influenza. We present a spreadsheet-based decision tree model that evaluates the impact of community-based NAI treatment in terms of the averted influenza-related hospitalizations and associated costeffectiveness in a range of pandemic scenarios. We found that community-based NAI treatment would avert a significant proportion of hospitalizations and deaths, particularly in high-risk patients, across the pandemic scenarios we explored in this analysis.	./cache/cord-011701-toevn37u.txt	./txt/cord-011701-toevn37u.txt