id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001989-6gi3o5mu	Faber, Timor	Meta-analyses including non-randomized studies of therapeutic interventions: a methodological review	2016-03-22		.txt	text/plain	8227	443	32	METHODS: For this methodological review, we searched MEDLINE via PubMed, from January 1, 2013 to December 31, 2013 for meta-analyses including at least one non-randomized study evaluating therapeutic interventions. CONCLUSIONS: Some key methodological components of the systematic review process—search for grey literature, description of the type of NRSI included, assessment of risk of confounding bias and reporting of whether crude or adjusted estimates were combined—are not adequately carried out or reported in meta-analyses including NRSI. Therefore, an increasing number of systematic reviews and meta-analyses are including data from non-randomized studies to assess therapeutic interventions. To illustrate: a metaanalysis that investigated the association of the use of statins and risk of cancer would was considered a therapeutic evaluation if the authors planned to include RCTs. Individual patient data meta-analyses were also excluded, as were non-randomized studies that conducted a meta-analysis of the literature as secondary analysis.	./cache/cord-001989-6gi3o5mu.txt	./txt/cord-001989-6gi3o5mu.txt