id sid tid token lemma pos cord-309161-ceahghs1 1 1 key key NN cord-309161-ceahghs1 1 2 : : : cord-309161-ceahghs1 1 3 cord-309161-ceahghs1 cord-309161-ceahghs1 NNP cord-309161-ceahghs1 1 4 authors author NNS cord-309161-ceahghs1 1 5 : : : cord-309161-ceahghs1 1 6 Epel Epel NNP cord-309161-ceahghs1 1 7 , , , cord-309161-ceahghs1 1 8 Elissa Elissa NNP cord-309161-ceahghs1 1 9 S. S. NNP cord-309161-ceahghs1 1 10 title title NN cord-309161-ceahghs1 1 11 : : : cord-309161-ceahghs1 2 1 The the DT cord-309161-ceahghs1 2 2 geroscience geroscience NN cord-309161-ceahghs1 2 3 agenda agenda NN cord-309161-ceahghs1 2 4 : : : cord-309161-ceahghs1 2 5 What what WP cord-309161-ceahghs1 2 6 does do VBZ cord-309161-ceahghs1 2 7 stress stress NN cord-309161-ceahghs1 2 8 have have VB cord-309161-ceahghs1 2 9 to to TO cord-309161-ceahghs1 2 10 do do VB cord-309161-ceahghs1 2 11 with with IN cord-309161-ceahghs1 2 12 it -PRON- PRP cord-309161-ceahghs1 2 13 ? ? . cord-309161-ceahghs1 3 1 date date NN cord-309161-ceahghs1 3 2 : : : cord-309161-ceahghs1 3 3 2020 2020 CD cord-309161-ceahghs1 3 4 - - HYPH cord-309161-ceahghs1 3 5 09 09 CD cord-309161-ceahghs1 3 6 - - HYPH cord-309161-ceahghs1 3 7 28 28 CD cord-309161-ceahghs1 3 8 journal journal NN cord-309161-ceahghs1 3 9 : : : cord-309161-ceahghs1 4 1 Ageing age VBG cord-309161-ceahghs1 4 2 Res Res NNP cord-309161-ceahghs1 4 3 Rev Rev NNP cord-309161-ceahghs1 4 4 DOI DOI NNP cord-309161-ceahghs1 4 5 : : : cord-309161-ceahghs1 4 6 10.1016 10.1016 CD cord-309161-ceahghs1 4 7 / / SYM cord-309161-ceahghs1 4 8 j.arr.2020.101167 j.arr.2020.101167 NNS cord-309161-ceahghs1 4 9 sha sha NNP cord-309161-ceahghs1 4 10 : : : cord-309161-ceahghs1 4 11 878f5e16439eac3eeef7710675fa9e03db5d1ed9 878f5e16439eac3eeef7710675fa9e03db5d1ed9 CD cord-309161-ceahghs1 4 12 doc_id doc_id CD cord-309161-ceahghs1 4 13 : : : cord-309161-ceahghs1 4 14 309161 309161 CD cord-309161-ceahghs1 4 15 cord_uid cord_uid FW cord-309161-ceahghs1 4 16 : : : cord-309161-ceahghs1 5 1 ceahghs1 ceahghs1 NNP cord-309161-ceahghs1 5 2 Geroscience Geroscience NNP cord-309161-ceahghs1 5 3 offers offer VBZ cord-309161-ceahghs1 5 4 a a DT cord-309161-ceahghs1 5 5 counterpoint counterpoint NN cord-309161-ceahghs1 5 6 to to IN cord-309161-ceahghs1 5 7 the the DT cord-309161-ceahghs1 5 8 challenged challenge VBN cord-309161-ceahghs1 5 9 pursuit pursuit NN cord-309161-ceahghs1 5 10 of of IN cord-309161-ceahghs1 5 11 curing cure VBG cord-309161-ceahghs1 5 12 diseases disease NNS cord-309161-ceahghs1 5 13 of of IN cord-309161-ceahghs1 5 14 aging age VBG cord-309161-ceahghs1 5 15 by by IN cord-309161-ceahghs1 5 16 focusing focus VBG cord-309161-ceahghs1 5 17 on on IN cord-309161-ceahghs1 5 18 slowing slow VBG cord-309161-ceahghs1 5 19 the the DT cord-309161-ceahghs1 5 20 biological biological JJ cord-309161-ceahghs1 5 21 aging aging NN cord-309161-ceahghs1 5 22 process process NN cord-309161-ceahghs1 5 23 for for IN cord-309161-ceahghs1 5 24 extended extend VBN cord-309161-ceahghs1 5 25 healthspan healthspan NNP cord-309161-ceahghs1 5 26 earlier early RBR cord-309161-ceahghs1 5 27 in in IN cord-309161-ceahghs1 5 28 life life NN cord-309161-ceahghs1 5 29 . . . cord-309161-ceahghs1 6 1 Remarkable remarkable JJ cord-309161-ceahghs1 6 2 progress progress NN cord-309161-ceahghs1 6 3 has have VBZ cord-309161-ceahghs1 6 4 led lead VBN cord-309161-ceahghs1 6 5 this this DT cord-309161-ceahghs1 6 6 field field NN cord-309161-ceahghs1 6 7 toward toward IN cord-309161-ceahghs1 6 8 animal animal NN cord-309161-ceahghs1 6 9 trials trial NNS cord-309161-ceahghs1 6 10 and and CC cord-309161-ceahghs1 6 11 the the DT cord-309161-ceahghs1 6 12 next next JJ cord-309161-ceahghs1 6 13 challenge challenge NN cord-309161-ceahghs1 6 14 lies lie VBZ cord-309161-ceahghs1 6 15 with with IN cord-309161-ceahghs1 6 16 translation translation NN cord-309161-ceahghs1 6 17 to to IN cord-309161-ceahghs1 6 18 humans human NNS cord-309161-ceahghs1 6 19 . . . cord-309161-ceahghs1 7 1 There there EX cord-309161-ceahghs1 7 2 is be VBZ cord-309161-ceahghs1 7 3 an an DT cord-309161-ceahghs1 7 4 emerging emerge VBG cord-309161-ceahghs1 7 5 number number NN cord-309161-ceahghs1 7 6 of of IN cord-309161-ceahghs1 7 7 small small JJ cord-309161-ceahghs1 7 8 human human JJ cord-309161-ceahghs1 7 9 trials trial NNS cord-309161-ceahghs1 7 10 that that WDT cord-309161-ceahghs1 7 11 can can MD cord-309161-ceahghs1 7 12 take take VB cord-309161-ceahghs1 7 13 advantage advantage NN cord-309161-ceahghs1 7 14 of of IN cord-309161-ceahghs1 7 15 new new JJ cord-309161-ceahghs1 7 16 models model NNS cord-309161-ceahghs1 7 17 integrating integrate VBG cord-309161-ceahghs1 7 18 behavioral behavioral JJ cord-309161-ceahghs1 7 19 and and CC cord-309161-ceahghs1 7 20 social social JJ cord-309161-ceahghs1 7 21 factors factor NNS cord-309161-ceahghs1 7 22 . . . cord-309161-ceahghs1 8 1 Understanding understand VBG cord-309161-ceahghs1 8 2 dynamic dynamic JJ cord-309161-ceahghs1 8 3 aging aging NN cord-309161-ceahghs1 8 4 mechanisms mechanism NNS cord-309161-ceahghs1 8 5 , , , cord-309161-ceahghs1 8 6 given give VBN cord-309161-ceahghs1 8 7 the the DT cord-309161-ceahghs1 8 8 powerful powerful JJ cord-309161-ceahghs1 8 9 social social JJ cord-309161-ceahghs1 8 10 determinants determinant NNS cord-309161-ceahghs1 8 11 of of IN cord-309161-ceahghs1 8 12 aging age VBG cord-309161-ceahghs1 8 13 ( ( -LRB- cord-309161-ceahghs1 8 14 Crimmins Crimmins NNP cord-309161-ceahghs1 8 15 , , , cord-309161-ceahghs1 8 16 2019 2019 CD cord-309161-ceahghs1 8 17 ) ) -RRB- cord-309161-ceahghs1 8 18 and and CC cord-309161-ceahghs1 8 19 human human JJ cord-309161-ceahghs1 8 20 variability variability NN cord-309161-ceahghs1 8 21 and and CC cord-309161-ceahghs1 8 22 environmental environmental JJ cord-309161-ceahghs1 8 23 contexts context NNS cord-309161-ceahghs1 8 24 ( ( -LRB- cord-309161-ceahghs1 8 25 Moffitt Moffitt NNP cord-309161-ceahghs1 8 26 , , , cord-309161-ceahghs1 8 27 2019 2019 CD cord-309161-ceahghs1 8 28 ) ) -RRB- cord-309161-ceahghs1 8 29 , , , cord-309161-ceahghs1 8 30 will will MD cord-309161-ceahghs1 8 31 be be VB cord-309161-ceahghs1 8 32 critical critical JJ cord-309161-ceahghs1 8 33 . . . cord-309161-ceahghs1 9 1 Behavioral behavioral JJ cord-309161-ceahghs1 9 2 and and CC cord-309161-ceahghs1 9 3 social social JJ cord-309161-ceahghs1 9 4 factors factor NNS cord-309161-ceahghs1 9 5 are be VBP cord-309161-ceahghs1 9 6 intrinsic intrinsic JJ cord-309161-ceahghs1 9 7 to to IN cord-309161-ceahghs1 9 8 aging age VBG cord-309161-ceahghs1 9 9 . . . cord-309161-ceahghs1 10 1 Toxic toxic JJ cord-309161-ceahghs1 10 2 stressors stressor NNS cord-309161-ceahghs1 10 3 broadly broadly RB cord-309161-ceahghs1 10 4 defined define VBN cord-309161-ceahghs1 10 5 can can MD cord-309161-ceahghs1 10 6 lead lead VB cord-309161-ceahghs1 10 7 to to IN cord-309161-ceahghs1 10 8 stress stress NN cord-309161-ceahghs1 10 9 - - HYPH cord-309161-ceahghs1 10 10 acceleration acceleration NN cord-309161-ceahghs1 10 11 of of IN cord-309161-ceahghs1 10 12 aging aging NN cord-309161-ceahghs1 10 13 , , , cord-309161-ceahghs1 10 14 either either CC cord-309161-ceahghs1 10 15 directly directly RB cord-309161-ceahghs1 10 16 impacting impact VBG cord-309161-ceahghs1 10 17 aging age VBG cord-309161-ceahghs1 10 18 processes process NNS cord-309161-ceahghs1 10 19 or or CC cord-309161-ceahghs1 10 20 by by IN cord-309161-ceahghs1 10 21 shaping shape VBG cord-309161-ceahghs1 10 22 poor poor JJ cord-309161-ceahghs1 10 23 behavioral behavioral JJ cord-309161-ceahghs1 10 24 health health NN cord-309161-ceahghs1 10 25 , , , cord-309161-ceahghs1 10 26 and and CC cord-309161-ceahghs1 10 27 underlie underlie VB cord-309161-ceahghs1 10 28 the the DT cord-309161-ceahghs1 10 29 socioeconomic socioeconomic JJ cord-309161-ceahghs1 10 30 disparities disparity NNS cord-309161-ceahghs1 10 31 of of IN cord-309161-ceahghs1 10 32 aging age VBG cord-309161-ceahghs1 10 33 . . . cord-309161-ceahghs1 11 1 In in IN cord-309161-ceahghs1 11 2 contrast contrast NN cord-309161-ceahghs1 11 3 , , , cord-309161-ceahghs1 11 4 hormetic hormetic JJ cord-309161-ceahghs1 11 5 stressors stressor NNS cord-309161-ceahghs1 11 6 , , , cord-309161-ceahghs1 11 7 acute acute JJ cord-309161-ceahghs1 11 8 intermittent intermittent JJ cord-309161-ceahghs1 11 9 stressors stressor NNS cord-309161-ceahghs1 11 10 of of IN cord-309161-ceahghs1 11 11 moderate moderate JJ cord-309161-ceahghs1 11 12 intensity intensity NN cord-309161-ceahghs1 11 13 , , , cord-309161-ceahghs1 11 14 can can MD cord-309161-ceahghs1 11 15 produce produce VB cord-309161-ceahghs1 11 16 stress stress NN cord-309161-ceahghs1 11 17 resilience resilience NN cord-309161-ceahghs1 11 18 , , , cord-309161-ceahghs1 11 19 the the DT cord-309161-ceahghs1 11 20 ability ability NN cord-309161-ceahghs1 11 21 for for IN cord-309161-ceahghs1 11 22 quick quick JJ cord-309161-ceahghs1 11 23 recovery recovery NN cord-309161-ceahghs1 11 24 and and CC cord-309161-ceahghs1 11 25 possibly possibly RB cord-309161-ceahghs1 11 26 rejuvenation rejuvenation NN cord-309161-ceahghs1 11 27 of of IN cord-309161-ceahghs1 11 28 cells cell NNS cord-309161-ceahghs1 11 29 and and CC cord-309161-ceahghs1 11 30 tissues tissue NNS cord-309161-ceahghs1 11 31 . . . cord-309161-ceahghs1 12 1 Although although IN cord-309161-ceahghs1 12 2 health health NN cord-309161-ceahghs1 12 3 research research NN cord-309161-ceahghs1 12 4 usually usually RB cord-309161-ceahghs1 12 5 examines examine VBZ cord-309161-ceahghs1 12 6 static static JJ cord-309161-ceahghs1 12 7 biomarkers biomarker NNS cord-309161-ceahghs1 12 8 , , , cord-309161-ceahghs1 12 9 aging age VBG cord-309161-ceahghs1 12 10 is be VBZ cord-309161-ceahghs1 12 11 reflected reflect VBN cord-309161-ceahghs1 12 12 in in IN cord-309161-ceahghs1 12 13 ability ability NN cord-309161-ceahghs1 12 14 to to TO cord-309161-ceahghs1 12 15 recover recover VB cord-309161-ceahghs1 12 16 from from IN cord-309161-ceahghs1 12 17 challenges challenge NNS cord-309161-ceahghs1 12 18 pointing point VBG cord-309161-ceahghs1 12 19 to to IN cord-309161-ceahghs1 12 20 new new JJ cord-309161-ceahghs1 12 21 interventions intervention NNS cord-309161-ceahghs1 12 22 and and CC cord-309161-ceahghs1 12 23 targets target NNS cord-309161-ceahghs1 12 24 for for IN cord-309161-ceahghs1 12 25 examining examine VBG cord-309161-ceahghs1 12 26 mechanisms mechanism NNS cord-309161-ceahghs1 12 27 . . . cord-309161-ceahghs1 13 1 A a DT cord-309161-ceahghs1 13 2 fuller full JJR cord-309161-ceahghs1 13 3 model model NN cord-309161-ceahghs1 13 4 incorporating incorporate VBG cord-309161-ceahghs1 13 5 stress stress NN cord-309161-ceahghs1 13 6 resilience resilience NN cord-309161-ceahghs1 13 7 provides provide VBZ cord-309161-ceahghs1 13 8 innovative innovative JJ cord-309161-ceahghs1 13 9 biobehavioral biobehavioral JJ cord-309161-ceahghs1 13 10 interventions intervention NNS cord-309161-ceahghs1 13 11 , , , cord-309161-ceahghs1 13 12 both both CC cord-309161-ceahghs1 13 13 for for IN cord-309161-ceahghs1 13 14 bolstering bolster VBG cord-309161-ceahghs1 13 15 response response NN cord-309161-ceahghs1 13 16 to to IN cord-309161-ceahghs1 13 17 challenges challenge NNS cord-309161-ceahghs1 13 18 , , , cord-309161-ceahghs1 13 19 such such JJ cord-309161-ceahghs1 13 20 as as IN cord-309161-ceahghs1 13 21 COVID-19 COVID-19 NNP cord-309161-ceahghs1 13 22 , , , cord-309161-ceahghs1 13 23 and and CC cord-309161-ceahghs1 13 24 for for IN cord-309161-ceahghs1 13 25 improving improve VBG cord-309161-ceahghs1 13 26 healthspan healthspan NNP cord-309161-ceahghs1 13 27 . . . cord-309161-ceahghs1 14 1 circumstances circumstance NNS cord-309161-ceahghs1 14 2 and and CC cord-309161-ceahghs1 14 3 substances substance NNS cord-309161-ceahghs1 14 4 . . . cord-309161-ceahghs1 15 1 Hormesis Hormesis NNP cord-309161-ceahghs1 15 2 traditionally traditionally RB cord-309161-ceahghs1 15 3 described describe VBD cord-309161-ceahghs1 15 4 a a DT cord-309161-ceahghs1 15 5 cells cell NNS cord-309161-ceahghs1 15 6 or or CC cord-309161-ceahghs1 15 7 organisms organism NNS cord-309161-ceahghs1 15 8 bi bi JJ cord-309161-ceahghs1 15 9 - - JJ cord-309161-ceahghs1 15 10 phasic phasic JJ cord-309161-ceahghs1 15 11 response response NN cord-309161-ceahghs1 15 12 to to IN cord-309161-ceahghs1 15 13 an an DT cord-309161-ceahghs1 15 14 external external JJ cord-309161-ceahghs1 15 15 chemical chemical NN cord-309161-ceahghs1 15 16 or or CC cord-309161-ceahghs1 15 17 stressor stressor NN cord-309161-ceahghs1 15 18 . . . cord-309161-ceahghs1 16 1 There there EX cord-309161-ceahghs1 16 2 is be VBZ cord-309161-ceahghs1 16 3 indeed indeed RB cord-309161-ceahghs1 16 4 overlap overlap NN cord-309161-ceahghs1 16 5 between between IN cord-309161-ceahghs1 16 6 stress stress NN cord-309161-ceahghs1 16 7 processes process NNS cord-309161-ceahghs1 16 8 and and CC cord-309161-ceahghs1 16 9 aging age VBG cord-309161-ceahghs1 16 10 processes process NNS cord-309161-ceahghs1 16 11 , , , cord-309161-ceahghs1 16 12 and and CC cord-309161-ceahghs1 16 13 two two CD cord-309161-ceahghs1 16 14 become become VBP cord-309161-ceahghs1 16 15 intertwined intertwine VBN cord-309161-ceahghs1 16 16 with with IN cord-309161-ceahghs1 16 17 the the DT cord-309161-ceahghs1 16 18 concept concept NN cord-309161-ceahghs1 16 19 of of IN cord-309161-ceahghs1 16 20 hormesis hormesis NN cord-309161-ceahghs1 16 21 . . . cord-309161-ceahghs1 17 1 Toxic toxic JJ cord-309161-ceahghs1 17 2 stress stress NN cord-309161-ceahghs1 17 3 includes include VBZ cord-309161-ceahghs1 17 4 traumatic traumatic JJ cord-309161-ceahghs1 17 5 or or CC cord-309161-ceahghs1 17 6 ongoing ongoing JJ cord-309161-ceahghs1 17 7 adversity adversity NN cord-309161-ceahghs1 17 8 for for IN cord-309161-ceahghs1 17 9 months month NNS cord-309161-ceahghs1 17 10 on on IN cord-309161-ceahghs1 17 11 end end NN cord-309161-ceahghs1 17 12 , , , cord-309161-ceahghs1 17 13 and and CC cord-309161-ceahghs1 17 14 the the DT cord-309161-ceahghs1 17 15 psychological psychological JJ cord-309161-ceahghs1 17 16 responses response NNS cord-309161-ceahghs1 17 17 -- -- : cord-309161-ceahghs1 17 18 chronic chronic JJ cord-309161-ceahghs1 17 19 high high JJ cord-309161-ceahghs1 17 20 perceived perceive VBN cord-309161-ceahghs1 17 21 stress stress NN cord-309161-ceahghs1 17 22 , , , cord-309161-ceahghs1 17 23 burnout burnout NN cord-309161-ceahghs1 17 24 , , , cord-309161-ceahghs1 17 25 or or CC cord-309161-ceahghs1 17 26 depression depression NN cord-309161-ceahghs1 17 27 . . . cord-309161-ceahghs1 18 1 Many many JJ cord-309161-ceahghs1 18 2 large large JJ cord-309161-ceahghs1 18 3 scale scale NN cord-309161-ceahghs1 18 4 studies study NNS cord-309161-ceahghs1 18 5 demonstrate demonstrate VBP cord-309161-ceahghs1 18 6 that that IN cord-309161-ceahghs1 18 7 traumatic traumatic JJ cord-309161-ceahghs1 18 8 or or CC cord-309161-ceahghs1 18 9 chronic chronic JJ cord-309161-ceahghs1 18 10 psychosocial psychosocial JJ cord-309161-ceahghs1 18 11 adversity adversity NN cord-309161-ceahghs1 18 12 , , , cord-309161-ceahghs1 18 13 including include VBG cord-309161-ceahghs1 18 14 low low JJ cord-309161-ceahghs1 18 15 socioeconomic socioeconomic JJ cord-309161-ceahghs1 18 16 status status NN cord-309161-ceahghs1 18 17 , , , cord-309161-ceahghs1 18 18 predict predict VB cord-309161-ceahghs1 18 19 higher high JJR cord-309161-ceahghs1 18 20 allostatic allostatic JJ cord-309161-ceahghs1 18 21 load load NN cord-309161-ceahghs1 18 22 , , , cord-309161-ceahghs1 18 23 whereas whereas IN cord-309161-ceahghs1 18 24 high high JJ cord-309161-ceahghs1 18 25 levels level NNS cord-309161-ceahghs1 18 26 of of IN cord-309161-ceahghs1 18 27 psychosocial psychosocial JJ cord-309161-ceahghs1 18 28 resources resource NNS cord-309161-ceahghs1 18 29 are be VBP cord-309161-ceahghs1 18 30 associated associate VBN cord-309161-ceahghs1 18 31 with with IN cord-309161-ceahghs1 18 32 lower low JJR cord-309161-ceahghs1 18 33 allostatic allostatic JJ cord-309161-ceahghs1 18 34 load load NN cord-309161-ceahghs1 18 35 , , , cord-309161-ceahghs1 18 36 with with IN cord-309161-ceahghs1 18 37 small small JJ cord-309161-ceahghs1 18 38 but but CC cord-309161-ceahghs1 18 39 reliable reliable JJ cord-309161-ceahghs1 18 40 effects effect NNS cord-309161-ceahghs1 18 41 ( ( -LRB- cord-309161-ceahghs1 18 42 Danese Danese NNP cord-309161-ceahghs1 18 43 & & CC cord-309161-ceahghs1 18 44 McEwen McEwen NNP cord-309161-ceahghs1 18 45 , , , cord-309161-ceahghs1 18 46 2012 2012 CD cord-309161-ceahghs1 18 47 ; ; : cord-309161-ceahghs1 18 48 Wiley Wiley NNP cord-309161-ceahghs1 18 49 et et NNP cord-309161-ceahghs1 18 50 al al NNP cord-309161-ceahghs1 18 51 . . NNP cord-309161-ceahghs1 18 52 , , , cord-309161-ceahghs1 18 53 2017 2017 CD cord-309161-ceahghs1 18 54 ) ) -RRB- cord-309161-ceahghs1 18 55 , , , cord-309161-ceahghs1 18 56 described describe VBN cord-309161-ceahghs1 18 57 further further RB cord-309161-ceahghs1 18 58 under under IN cord-309161-ceahghs1 18 59 " " `` cord-309161-ceahghs1 18 60 reserve reserve NN cord-309161-ceahghs1 18 61 capacity capacity NN cord-309161-ceahghs1 18 62 " " '' cord-309161-ceahghs1 18 63 ( ( -LRB- cord-309161-ceahghs1 18 64 Section section NN cord-309161-ceahghs1 18 65 3 3 CD cord-309161-ceahghs1 18 66 ) ) -RRB- cord-309161-ceahghs1 18 67 . . . cord-309161-ceahghs1 19 1 Homeostasis homeostasis NN cord-309161-ceahghs1 19 2 to to IN cord-309161-ceahghs1 19 3 Allostatic Allostatic NNP cord-309161-ceahghs1 19 4 Load Load NNP cord-309161-ceahghs1 19 5 . . . cord-309161-ceahghs1 20 1 Stress stress NN cord-309161-ceahghs1 20 2 research research NN cord-309161-ceahghs1 20 3 started start VBD cord-309161-ceahghs1 20 4 with with IN cord-309161-ceahghs1 20 5 examination examination NN cord-309161-ceahghs1 20 6 of of IN cord-309161-ceahghs1 20 7 the the DT cord-309161-ceahghs1 20 8 acute acute JJ cord-309161-ceahghs1 20 9 stress stress NN cord-309161-ceahghs1 20 10 responses response NNS cord-309161-ceahghs1 20 11 to to IN cord-309161-ceahghs1 20 12 acute acute JJ cord-309161-ceahghs1 20 13 stressors stressor NNS cord-309161-ceahghs1 20 14 in in IN cord-309161-ceahghs1 20 15 rodents rodent NNS cord-309161-ceahghs1 20 16 . . . cord-309161-ceahghs1 21 1 Cannon Cannon NNP cord-309161-ceahghs1 21 2 's 's POS cord-309161-ceahghs1 21 3 stress stress NN cord-309161-ceahghs1 21 4 studies study NNS cord-309161-ceahghs1 21 5 led lead VBD cord-309161-ceahghs1 21 6 to to IN cord-309161-ceahghs1 21 7 the the DT cord-309161-ceahghs1 21 8 popular popular JJ cord-309161-ceahghs1 21 9 concept concept NN cord-309161-ceahghs1 21 10 of of IN cord-309161-ceahghs1 21 11 homeostasis homeostasis NN cord-309161-ceahghs1 21 12 ( ( -LRB- cord-309161-ceahghs1 21 13 Cannon Cannon NNP cord-309161-ceahghs1 21 14 , , , cord-309161-ceahghs1 21 15 1932 1932 CD cord-309161-ceahghs1 21 16 ) ) -RRB- cord-309161-ceahghs1 21 17 but but CC cord-309161-ceahghs1 21 18 a a DT cord-309161-ceahghs1 21 19 simple simple JJ cord-309161-ceahghs1 21 20 linear linear JJ cord-309161-ceahghs1 21 21 model model NN cord-309161-ceahghs1 21 22 of of IN cord-309161-ceahghs1 21 23 homeostasis homeostasis NN cord-309161-ceahghs1 21 24 does do VBZ cord-309161-ceahghs1 21 25 not not RB cord-309161-ceahghs1 21 26 explain explain VB cord-309161-ceahghs1 21 27 the the DT cord-309161-ceahghs1 21 28 range range NN cord-309161-ceahghs1 21 29 of of IN cord-309161-ceahghs1 21 30 human human JJ cord-309161-ceahghs1 21 31 stress stress NN cord-309161-ceahghs1 21 32 responses response NNS cord-309161-ceahghs1 21 33 , , , cord-309161-ceahghs1 21 34 and and CC cord-309161-ceahghs1 21 35 there there EX cord-309161-ceahghs1 21 36 have have VBP cord-309161-ceahghs1 21 37 been be VBN cord-309161-ceahghs1 21 38 many many JJ cord-309161-ceahghs1 21 39 elaborations elaboration NNS cord-309161-ceahghs1 21 40 of of IN cord-309161-ceahghs1 21 41 this this DT cord-309161-ceahghs1 21 42 concept concept NN cord-309161-ceahghs1 21 43 . . . cord-309161-ceahghs1 22 1 Selye Selye NNP cord-309161-ceahghs1 22 2 described describe VBD cord-309161-ceahghs1 22 3 the the DT cord-309161-ceahghs1 22 4 continuum continuum NN cord-309161-ceahghs1 22 5 from from IN cord-309161-ceahghs1 22 6 acute acute JJ cord-309161-ceahghs1 22 7 stress stress NN cord-309161-ceahghs1 22 8 to to IN cord-309161-ceahghs1 22 9 chronic chronic JJ cord-309161-ceahghs1 22 10 stress stress NN cord-309161-ceahghs1 22 11 ( ( -LRB- cord-309161-ceahghs1 22 12 Selye Selye NNP cord-309161-ceahghs1 22 13 , , , cord-309161-ceahghs1 22 14 1956 1956 CD cord-309161-ceahghs1 22 15 ) ) -RRB- cord-309161-ceahghs1 22 16 . . . cord-309161-ceahghs1 23 1 Acute acute JJ cord-309161-ceahghs1 23 2 stress stress NN cord-309161-ceahghs1 23 3 can can MD cord-309161-ceahghs1 23 4 be be VB cord-309161-ceahghs1 23 5 hormetic hormetic JJ cord-309161-ceahghs1 23 6 when when WRB cord-309161-ceahghs1 23 7 there there EX cord-309161-ceahghs1 23 8 is be VBZ cord-309161-ceahghs1 23 9 quick quick JJ cord-309161-ceahghs1 23 10 recovery recovery NN cord-309161-ceahghs1 23 11 back back RB cord-309161-ceahghs1 23 12 to to IN cord-309161-ceahghs1 23 13 homeostasis homeostasis NN cord-309161-ceahghs1 23 14 . . . cord-309161-ceahghs1 24 1 Given give VBN cord-309161-ceahghs1 24 2 the the DT cord-309161-ceahghs1 24 3 complexity complexity NN cord-309161-ceahghs1 24 4 of of IN cord-309161-ceahghs1 24 5 physiological physiological JJ cord-309161-ceahghs1 24 6 regulation regulation NN cord-309161-ceahghs1 24 7 , , , cord-309161-ceahghs1 24 8 and and CC cord-309161-ceahghs1 24 9 that that IN cord-309161-ceahghs1 24 10 our -PRON- PRP$ cord-309161-ceahghs1 24 11 body body NN cord-309161-ceahghs1 24 12 mounts mount VBZ cord-309161-ceahghs1 24 13 a a DT cord-309161-ceahghs1 24 14 response response NN cord-309161-ceahghs1 24 15 in in IN cord-309161-ceahghs1 24 16 mere mere JJ cord-309161-ceahghs1 24 17 anticipation anticipation NN cord-309161-ceahghs1 24 18 of of IN cord-309161-ceahghs1 24 19 threat threat NN cord-309161-ceahghs1 24 20 , , , cord-309161-ceahghs1 24 21 Sterling sterling NN cord-309161-ceahghs1 24 22 and and CC cord-309161-ceahghs1 24 23 colleagues colleague NNS cord-309161-ceahghs1 24 24 have have VBP cord-309161-ceahghs1 24 25 described describe VBN cord-309161-ceahghs1 24 26 allostasis allostasis NN cord-309161-ceahghs1 24 27 as as IN cord-309161-ceahghs1 24 28 a a DT cord-309161-ceahghs1 24 29 more more RBR cord-309161-ceahghs1 24 30 encompassing encompassing JJ cord-309161-ceahghs1 24 31 description description NN cord-309161-ceahghs1 24 32 of of IN cord-309161-ceahghs1 24 33 the the DT cord-309161-ceahghs1 24 34 body body NN cord-309161-ceahghs1 24 35 's 's POS cord-309161-ceahghs1 24 36 regulation regulation NN cord-309161-ceahghs1 24 37 - - , cord-309161-ceahghs1 24 38 the the DT cord-309161-ceahghs1 24 39 constant constant JJ cord-309161-ceahghs1 24 40 fluctuations fluctuation NNS cord-309161-ceahghs1 24 41 to to TO cord-309161-ceahghs1 24 42 meet meet VB cord-309161-ceahghs1 24 43 expected expected JJ cord-309161-ceahghs1 24 44 demands demand NNS cord-309161-ceahghs1 24 45 ( ( -LRB- cord-309161-ceahghs1 24 46 Schulkin Schulkin NNP cord-309161-ceahghs1 24 47 & & CC cord-309161-ceahghs1 24 48 Sterling Sterling NNP cord-309161-ceahghs1 24 49 , , , cord-309161-ceahghs1 24 50 2019 2019 CD cord-309161-ceahghs1 24 51 ) ) -RRB- cord-309161-ceahghs1 24 52 which which WDT cord-309161-ceahghs1 24 53 in in IN cord-309161-ceahghs1 24 54 biogerontology biogerontology NNP cord-309161-ceahghs1 24 55 has have VBZ cord-309161-ceahghs1 24 56 been be VBN cord-309161-ceahghs1 24 57 called call VBN cord-309161-ceahghs1 24 58 " " `` cord-309161-ceahghs1 24 59 homeodynamics homeodynamic NNS cord-309161-ceahghs1 24 60 . . . cord-309161-ceahghs1 25 1 " " `` cord-309161-ceahghs1 25 2 Chronicity chronicity NN cord-309161-ceahghs1 25 3 of of IN cord-309161-ceahghs1 25 4 stressor stressor NN cord-309161-ceahghs1 25 5 exposure exposure NN cord-309161-ceahghs1 25 6 reveals reveal VBZ cord-309161-ceahghs1 25 7 a a DT cord-309161-ceahghs1 25 8 " " `` cord-309161-ceahghs1 25 9 fragility fragility NN cord-309161-ceahghs1 25 10 in in IN cord-309161-ceahghs1 25 11 homeostasis homeostasis NN cord-309161-ceahghs1 25 12 " " '' cord-309161-ceahghs1 25 13 ( ( -LRB- cord-309161-ceahghs1 25 14 Ramsay Ramsay NNP cord-309161-ceahghs1 25 15 & & CC cord-309161-ceahghs1 25 16 Woods Woods NNP cord-309161-ceahghs1 25 17 , , , cord-309161-ceahghs1 25 18 2014 2014 CD cord-309161-ceahghs1 25 19 ) ) -RRB- cord-309161-ceahghs1 25 20 when when WRB cord-309161-ceahghs1 25 21 physiological physiological JJ cord-309161-ceahghs1 25 22 signs sign NNS cord-309161-ceahghs1 25 23 of of IN cord-309161-ceahghs1 25 24 ' ' `` cord-309161-ceahghs1 25 25 exhaustion exhaustion NN cord-309161-ceahghs1 25 26 ' ' '' cord-309161-ceahghs1 25 27 appear appear VBP cord-309161-ceahghs1 25 28 , , , cord-309161-ceahghs1 25 29 such such JJ cord-309161-ceahghs1 25 30 as as IN cord-309161-ceahghs1 25 31 , , , cord-309161-ceahghs1 25 32 in in IN cord-309161-ceahghs1 25 33 rodents rodent NNS cord-309161-ceahghs1 25 34 , , , cord-309161-ceahghs1 25 35 damage damage NN cord-309161-ceahghs1 25 36 in in IN cord-309161-ceahghs1 25 37 organs organ NNS cord-309161-ceahghs1 25 38 . . . cord-309161-ceahghs1 26 1 McEwen McEwen NNP cord-309161-ceahghs1 26 2 and and CC cord-309161-ceahghs1 26 3 colleagues colleague NNS cord-309161-ceahghs1 26 4 have have VBP cord-309161-ceahghs1 26 5 labeled label VBN cord-309161-ceahghs1 26 6 this this DT cord-309161-ceahghs1 26 7 cost cost NN cord-309161-ceahghs1 26 8 of of IN cord-309161-ceahghs1 26 9 adaptation adaptation NN cord-309161-ceahghs1 26 10 -- -- : cord-309161-ceahghs1 26 11 the the DT cord-309161-ceahghs1 26 12 dysregulation dysregulation NN cord-309161-ceahghs1 26 13 and and CC cord-309161-ceahghs1 26 14 damage damage NN cord-309161-ceahghs1 26 15 across across IN cord-309161-ceahghs1 26 16 systems system NNS cord-309161-ceahghs1 26 17 -- -- : cord-309161-ceahghs1 26 18 as as IN cord-309161-ceahghs1 26 19 allostatic allostatic JJ cord-309161-ceahghs1 26 20 load load NN cord-309161-ceahghs1 26 21 ( ( -LRB- cord-309161-ceahghs1 26 22 McEwen McEwen NNP cord-309161-ceahghs1 26 23 , , , cord-309161-ceahghs1 26 24 2004 2004 CD cord-309161-ceahghs1 26 25 ) ) -RRB- cord-309161-ceahghs1 26 26 . . . cord-309161-ceahghs1 27 1 The the DT cord-309161-ceahghs1 27 2 concept concept NN cord-309161-ceahghs1 27 3 of of IN cord-309161-ceahghs1 27 4 allostatic allostatic JJ cord-309161-ceahghs1 27 5 load load NN cord-309161-ceahghs1 27 6 , , , cord-309161-ceahghs1 27 7 whether whether IN cord-309161-ceahghs1 27 8 it -PRON- PRP cord-309161-ceahghs1 27 9 is be VBZ cord-309161-ceahghs1 27 10 at at IN cord-309161-ceahghs1 27 11 a a DT cord-309161-ceahghs1 27 12 systemic systemic JJ cord-309161-ceahghs1 27 13 or or CC cord-309161-ceahghs1 27 14 cellular cellular JJ cord-309161-ceahghs1 27 15 level level NN cord-309161-ceahghs1 27 16 , , , cord-309161-ceahghs1 27 17 gives give VBZ cord-309161-ceahghs1 27 18 us -PRON- PRP cord-309161-ceahghs1 27 19 an an DT cord-309161-ceahghs1 27 20 intermediate intermediate JJ cord-309161-ceahghs1 27 21 phenotype phenotype NN cord-309161-ceahghs1 27 22 of of IN cord-309161-ceahghs1 27 23 aging age VBG cord-309161-ceahghs1 27 24 , , , cord-309161-ceahghs1 27 25 an an DT cord-309161-ceahghs1 27 26 early early JJ cord-309161-ceahghs1 27 27 step step NN cord-309161-ceahghs1 27 28 toward toward IN cord-309161-ceahghs1 27 29 development development NN cord-309161-ceahghs1 27 30 of of IN cord-309161-ceahghs1 27 31 diagnosable diagnosable JJ cord-309161-ceahghs1 27 32 disease disease NN cord-309161-ceahghs1 27 33 . . . cord-309161-ceahghs1 28 1 This this DT cord-309161-ceahghs1 28 2 is be VBZ cord-309161-ceahghs1 28 3 a a DT cord-309161-ceahghs1 28 4 critical critical JJ cord-309161-ceahghs1 28 5 concept concept NN cord-309161-ceahghs1 28 6 to to IN cord-309161-ceahghs1 28 7 geroscience geroscience NNP cord-309161-ceahghs1 28 8 , , , cord-309161-ceahghs1 28 9 and and CC cord-309161-ceahghs1 28 10 in in IN cord-309161-ceahghs1 28 11 fact fact NN cord-309161-ceahghs1 28 12 many many JJ cord-309161-ceahghs1 28 13 of of IN cord-309161-ceahghs1 28 14 the the DT cord-309161-ceahghs1 28 15 actual actual JJ cord-309161-ceahghs1 28 16 measures measure NNS cord-309161-ceahghs1 28 17 of of IN cord-309161-ceahghs1 28 18 allostatic allostatic NNP cord-309161-ceahghs1 28 19 J J NNP cord-309161-ceahghs1 28 20 o o NNP cord-309161-ceahghs1 28 21 u u NN cord-309161-ceahghs1 28 22 r r NNP cord-309161-ceahghs1 28 23 n n NN cord-309161-ceahghs1 28 24 a a DT cord-309161-ceahghs1 28 25 l l NN cord-309161-ceahghs1 28 26 P p NN cord-309161-ceahghs1 28 27 r r NN cord-309161-ceahghs1 28 28 e e NN cord-309161-ceahghs1 28 29 -p -p NN cord-309161-ceahghs1 29 1 r r NNP cord-309161-ceahghs1 29 2 o o NN cord-309161-ceahghs1 29 3 o o NN cord-309161-ceahghs1 29 4 f f NN cord-309161-ceahghs1 29 5 load load NN cord-309161-ceahghs1 29 6 used use VBN cord-309161-ceahghs1 29 7 in in IN cord-309161-ceahghs1 29 8 from from IN cord-309161-ceahghs1 29 9 the the DT cord-309161-ceahghs1 29 10 psychology psychology NN cord-309161-ceahghs1 29 11 and and CC cord-309161-ceahghs1 29 12 public public JJ cord-309161-ceahghs1 29 13 health health NN cord-309161-ceahghs1 29 14 literature literature NN cord-309161-ceahghs1 29 15 are be VBP cord-309161-ceahghs1 29 16 actually actually RB cord-309161-ceahghs1 29 17 indices index NNS cord-309161-ceahghs1 29 18 of of IN cord-309161-ceahghs1 29 19 aging age VBG cord-309161-ceahghs1 29 20 ( ( -LRB- cord-309161-ceahghs1 29 21 Entringer Entringer NNP cord-309161-ceahghs1 29 22 & & CC cord-309161-ceahghs1 29 23 Epel Epel NNP cord-309161-ceahghs1 29 24 , , , cord-309161-ceahghs1 29 25 2020 2020 CD cord-309161-ceahghs1 29 26 ) ) -RRB- cord-309161-ceahghs1 29 27 . . . cord-309161-ceahghs1 30 1 Geroscience geroscience NN cord-309161-ceahghs1 30 2 leaders leader NNS cord-309161-ceahghs1 30 3 have have VBP cord-309161-ceahghs1 30 4 started start VBN cord-309161-ceahghs1 30 5 to to TO cord-309161-ceahghs1 30 6 identify identify VB cord-309161-ceahghs1 30 7 the the DT cord-309161-ceahghs1 30 8 biomarkers biomarker NNS cord-309161-ceahghs1 30 9 important important JJ cord-309161-ceahghs1 30 10 in in IN cord-309161-ceahghs1 30 11 geroscience geroscience NN cord-309161-ceahghs1 30 12 trials trial NNS cord-309161-ceahghs1 30 13 , , , cord-309161-ceahghs1 30 14 as as IN cord-309161-ceahghs1 30 15 those those DT cord-309161-ceahghs1 30 16 that that WDT cord-309161-ceahghs1 30 17 can can MD cord-309161-ceahghs1 30 18 predict predict VB cord-309161-ceahghs1 30 19 aging age VBG cord-309161-ceahghs1 30 20 outcomes outcome NNS cord-309161-ceahghs1 30 21 and and CC cord-309161-ceahghs1 30 22 mortality mortality NN cord-309161-ceahghs1 30 23 , , , cord-309161-ceahghs1 30 24 and and CC cord-309161-ceahghs1 30 25 are be VBP cord-309161-ceahghs1 30 26 responsive responsive JJ cord-309161-ceahghs1 30 27 to to IN cord-309161-ceahghs1 30 28 interventions intervention NNS cord-309161-ceahghs1 30 29 , , , cord-309161-ceahghs1 30 30 and and CC cord-309161-ceahghs1 30 31 this this DT cord-309161-ceahghs1 30 32 short short JJ cord-309161-ceahghs1 30 33 list list NN cord-309161-ceahghs1 30 34 includes include VBZ cord-309161-ceahghs1 30 35 glucose glucose NN cord-309161-ceahghs1 30 36 control control NN cord-309161-ceahghs1 30 37 and and CC cord-309161-ceahghs1 30 38 inflammation inflammation NN cord-309161-ceahghs1 30 39 ( ( -LRB- cord-309161-ceahghs1 30 40 Justice Justice NNP cord-309161-ceahghs1 30 41 et et NNP cord-309161-ceahghs1 30 42 al al NNP cord-309161-ceahghs1 30 43 . . NNP cord-309161-ceahghs1 30 44 , , , cord-309161-ceahghs1 30 45 2018 2018 CD cord-309161-ceahghs1 30 46 ) ) -RRB- cord-309161-ceahghs1 30 47 . . . cord-309161-ceahghs1 31 1 Thus thus RB cord-309161-ceahghs1 31 2 , , , cord-309161-ceahghs1 31 3 there there EX cord-309161-ceahghs1 31 4 is be VBZ cord-309161-ceahghs1 31 5 potentially potentially RB cord-309161-ceahghs1 31 6 great great JJ cord-309161-ceahghs1 31 7 overlap overlap NN cord-309161-ceahghs1 31 8 between between IN cord-309161-ceahghs1 31 9 geroscience geroscience NN cord-309161-ceahghs1 31 10 biomarkers biomarker NNS cord-309161-ceahghs1 31 11 and and CC cord-309161-ceahghs1 31 12 the the DT cord-309161-ceahghs1 31 13 stress stress NN cord-309161-ceahghs1 31 14 - - HYPH cord-309161-ceahghs1 31 15 related relate VBN cord-309161-ceahghs1 31 16 allostatic allostatic JJ cord-309161-ceahghs1 31 17 load load NN cord-309161-ceahghs1 31 18 markers marker NNS cord-309161-ceahghs1 31 19 described describe VBN cord-309161-ceahghs1 31 20 in in IN cord-309161-ceahghs1 31 21 Section section NN cord-309161-ceahghs1 31 22 3 3 CD cord-309161-ceahghs1 31 23 ( ( -LRB- cord-309161-ceahghs1 31 24 cellular cellular JJ cord-309161-ceahghs1 31 25 , , , cord-309161-ceahghs1 31 26 multi multi JJ cord-309161-ceahghs1 31 27 - - NN cord-309161-ceahghs1 31 28 system system NN cord-309161-ceahghs1 31 29 , , , cord-309161-ceahghs1 31 30 and and CC cord-309161-ceahghs1 31 31 measures measure NNS cord-309161-ceahghs1 31 32 of of IN cord-309161-ceahghs1 31 33 recovery recovery NN cord-309161-ceahghs1 31 34 ) ) -RRB- cord-309161-ceahghs1 31 35 , , , cord-309161-ceahghs1 31 36 and and CC cord-309161-ceahghs1 31 37 these these DT cord-309161-ceahghs1 31 38 fields field NNS cord-309161-ceahghs1 31 39 can can MD cord-309161-ceahghs1 31 40 inform inform VB cord-309161-ceahghs1 31 41 each each DT cord-309161-ceahghs1 31 42 other other JJ cord-309161-ceahghs1 31 43 . . . cord-309161-ceahghs1 32 1 1 1 LS cord-309161-ceahghs1 32 2 . . . cord-309161-ceahghs1 33 1 An an DT cord-309161-ceahghs1 33 2 integrative integrative JJ cord-309161-ceahghs1 33 3 model model NN cord-309161-ceahghs1 33 4 of of IN cord-309161-ceahghs1 33 5 stress stress NN cord-309161-ceahghs1 33 6 and and CC cord-309161-ceahghs1 33 7 aging aging NN cord-309161-ceahghs1 33 8 . . . cord-309161-ceahghs1 34 1 Stress stress NN cord-309161-ceahghs1 34 2 acceleration acceleration NN cord-309161-ceahghs1 34 3 ( ( -LRB- cord-309161-ceahghs1 34 4 toxic toxic JJ cord-309161-ceahghs1 34 5 stress stress NN cord-309161-ceahghs1 34 6 ) ) -RRB- cord-309161-ceahghs1 34 7 and and CC cord-309161-ceahghs1 34 8 stress stress NN cord-309161-ceahghs1 34 9 rejuvenescence rejuvenescence NN cord-309161-ceahghs1 34 10 ( ( -LRB- cord-309161-ceahghs1 34 11 hormetic hormetic JJ cord-309161-ceahghs1 34 12 stress stress NN cord-309161-ceahghs1 34 13 ) ) -RRB- cord-309161-ceahghs1 34 14 . . . cord-309161-ceahghs1 35 1 Given give VBN cord-309161-ceahghs1 35 2 the the DT cord-309161-ceahghs1 35 3 important important JJ cord-309161-ceahghs1 35 4 role role NN cord-309161-ceahghs1 35 5 of of IN cord-309161-ceahghs1 35 6 social social JJ cord-309161-ceahghs1 35 7 stress stress NN cord-309161-ceahghs1 35 8 in in IN cord-309161-ceahghs1 35 9 aging age VBG cord-309161-ceahghs1 35 10 , , , cord-309161-ceahghs1 35 11 we -PRON- PRP cord-309161-ceahghs1 35 12 need need VBP cord-309161-ceahghs1 35 13 a a DT cord-309161-ceahghs1 35 14 deeper deep JJR cord-309161-ceahghs1 35 15 understanding understanding NN cord-309161-ceahghs1 35 16 of of IN cord-309161-ceahghs1 35 17 types type NNS cord-309161-ceahghs1 35 18 of of IN cord-309161-ceahghs1 35 19 stress stress NN cord-309161-ceahghs1 35 20 exposures exposure NNS cord-309161-ceahghs1 35 21 . . . cord-309161-ceahghs1 36 1 An an DT cord-309161-ceahghs1 36 2 overarching overarching JJ cord-309161-ceahghs1 36 3 model model NN cord-309161-ceahghs1 36 4 explains explain VBZ cord-309161-ceahghs1 36 5 the the DT cord-309161-ceahghs1 36 6 range range NN cord-309161-ceahghs1 36 7 of of IN cord-309161-ceahghs1 36 8 stress stress NN cord-309161-ceahghs1 36 9 exposures exposure NNS cord-309161-ceahghs1 36 10 , , , cord-309161-ceahghs1 36 11 from from IN cord-309161-ceahghs1 36 12 toxic toxic JJ cord-309161-ceahghs1 36 13 stress stress NN cord-309161-ceahghs1 36 14 to to IN cord-309161-ceahghs1 36 15 acute acute JJ cord-309161-ceahghs1 36 16 hormetic hormetic JJ cord-309161-ceahghs1 36 17 stress stress NN cord-309161-ceahghs1 36 18 , , , cord-309161-ceahghs1 36 19 and and CC cord-309161-ceahghs1 36 20 our -PRON- PRP$ cord-309161-ceahghs1 36 21 body body NN cord-309161-ceahghs1 36 22 's 's POS cord-309161-ceahghs1 36 23 diverging diverge VBG cord-309161-ceahghs1 36 24 responses response NNS cord-309161-ceahghs1 36 25 to to IN cord-309161-ceahghs1 36 26 these these DT cord-309161-ceahghs1 36 27 exposures exposure NNS cord-309161-ceahghs1 36 28 . . . cord-309161-ceahghs1 37 1 Our -PRON- PRP$ cord-309161-ceahghs1 37 2 stress stress NN cord-309161-ceahghs1 37 3 responses response NNS cord-309161-ceahghs1 37 4 are be VBP cord-309161-ceahghs1 37 5 not not RB cord-309161-ceahghs1 37 6 typically typically RB cord-309161-ceahghs1 37 7 thought think VBN cord-309161-ceahghs1 37 8 of of IN cord-309161-ceahghs1 37 9 as as RB cord-309161-ceahghs1 37 10 basic basic JJ cord-309161-ceahghs1 37 11 mechanisms mechanism NNS cord-309161-ceahghs1 37 12 of of IN cord-309161-ceahghs1 37 13 aging age VBG cord-309161-ceahghs1 37 14 but but CC cord-309161-ceahghs1 37 15 indeed indeed RB cord-309161-ceahghs1 37 16 they -PRON- PRP cord-309161-ceahghs1 37 17 are be VBP cord-309161-ceahghs1 37 18 actively actively RB cord-309161-ceahghs1 37 19 shaping shape VBG cord-309161-ceahghs1 37 20 rate rate NN cord-309161-ceahghs1 37 21 of of IN cord-309161-ceahghs1 37 22 aging age VBG cord-309161-ceahghs1 37 23 . . . cord-309161-ceahghs1 38 1 As as IN cord-309161-ceahghs1 38 2 shown show VBN cord-309161-ceahghs1 38 3 in in IN cord-309161-ceahghs1 38 4 Figure figure NN cord-309161-ceahghs1 38 5 1 1 CD cord-309161-ceahghs1 38 6 , , , cord-309161-ceahghs1 38 7 the the DT cord-309161-ceahghs1 38 8 dose dose NN cord-309161-ceahghs1 38 9 and and CC cord-309161-ceahghs1 38 10 intensity intensity NN cord-309161-ceahghs1 38 11 of of IN cord-309161-ceahghs1 38 12 the the DT cord-309161-ceahghs1 38 13 stressor stressor NN cord-309161-ceahghs1 38 14 determines determine VBZ cord-309161-ceahghs1 38 15 in in IN cord-309161-ceahghs1 38 16 part part NN cord-309161-ceahghs1 38 17 whether whether IN cord-309161-ceahghs1 38 18 the the DT cord-309161-ceahghs1 38 19 organism organism NN cord-309161-ceahghs1 38 20 responds respond VBZ cord-309161-ceahghs1 38 21 with with IN cord-309161-ceahghs1 38 22 positive positive JJ cord-309161-ceahghs1 38 23 physiological physiological JJ cord-309161-ceahghs1 38 24 changes change NNS cord-309161-ceahghs1 38 25 or or CC cord-309161-ceahghs1 38 26 impairments impairment NNS cord-309161-ceahghs1 38 27 in in IN cord-309161-ceahghs1 38 28 aging age VBG cord-309161-ceahghs1 38 29 processes process NNS cord-309161-ceahghs1 38 30 ( ( -LRB- cord-309161-ceahghs1 38 31 modified modify VBN cord-309161-ceahghs1 38 32 from from IN cord-309161-ceahghs1 38 33 Franceschi Franceschi NNP cord-309161-ceahghs1 38 34 et et NNP cord-309161-ceahghs1 38 35 al al NNP cord-309161-ceahghs1 38 36 . . NNP cord-309161-ceahghs1 38 37 , , , cord-309161-ceahghs1 38 38 2018 2018 CD cord-309161-ceahghs1 38 39 ) ) -RRB- cord-309161-ceahghs1 38 40 . . . cord-309161-ceahghs1 39 1 The the DT cord-309161-ceahghs1 39 2 exact exact JJ cord-309161-ceahghs1 39 3 timing timing NN cord-309161-ceahghs1 39 4 of of IN cord-309161-ceahghs1 39 5 stressor stressor NN cord-309161-ceahghs1 39 6 exposure exposure NN cord-309161-ceahghs1 39 7 is be VBZ cord-309161-ceahghs1 39 8 an an DT cord-309161-ceahghs1 39 9 important important JJ cord-309161-ceahghs1 39 10 consideration consideration NN cord-309161-ceahghs1 39 11 of of IN cord-309161-ceahghs1 39 12 a a DT cord-309161-ceahghs1 39 13 hormetic hormetic JJ cord-309161-ceahghs1 39 14 or or CC cord-309161-ceahghs1 39 15 pre pre JJ cord-309161-ceahghs1 39 16 - - JJ cord-309161-ceahghs1 39 17 conditioning conditioning JJ cord-309161-ceahghs1 39 18 effect effect NN cord-309161-ceahghs1 39 19 , , , cord-309161-ceahghs1 39 20 as as IN cord-309161-ceahghs1 39 21 some some DT cord-309161-ceahghs1 39 22 stressors stressor NNS cord-309161-ceahghs1 39 23 lead lead VBP cord-309161-ceahghs1 39 24 to to IN cord-309161-ceahghs1 39 25 sensitization sensitization NN cord-309161-ceahghs1 39 26 across across IN cord-309161-ceahghs1 39 27 stressors stressor NNS cord-309161-ceahghs1 39 28 , , , cord-309161-ceahghs1 39 29 rather rather RB cord-309161-ceahghs1 39 30 than than IN cord-309161-ceahghs1 39 31 habituation habituation NN cord-309161-ceahghs1 39 32 ( ( -LRB- cord-309161-ceahghs1 39 33 i.e. i.e. FW cord-309161-ceahghs1 39 34 , , , cord-309161-ceahghs1 39 35 Belda Belda NNP cord-309161-ceahghs1 39 36 et et NNP cord-309161-ceahghs1 39 37 al al NNP cord-309161-ceahghs1 39 38 . . NNP cord-309161-ceahghs1 39 39 , , , cord-309161-ceahghs1 39 40 2016 2016 CD cord-309161-ceahghs1 39 41 ) ) -RRB- cord-309161-ceahghs1 39 42 and and CC cord-309161-ceahghs1 39 43 this this DT cord-309161-ceahghs1 39 44 may may MD cord-309161-ceahghs1 39 45 differ differ VB cord-309161-ceahghs1 39 46 by by IN cord-309161-ceahghs1 39 47 species specie NNS cord-309161-ceahghs1 39 48 , , , cord-309161-ceahghs1 39 49 stage stage NN cord-309161-ceahghs1 39 50 of of IN cord-309161-ceahghs1 39 51 development development NN cord-309161-ceahghs1 39 52 , , , cord-309161-ceahghs1 39 53 and and CC cord-309161-ceahghs1 39 54 stressor stressor NN cord-309161-ceahghs1 39 55 paradigm paradigm NN cord-309161-ceahghs1 39 56 . . . cord-309161-ceahghs1 40 1 Therefore therefore RB cord-309161-ceahghs1 40 2 , , , cord-309161-ceahghs1 40 3 a a DT cord-309161-ceahghs1 40 4 general general JJ cord-309161-ceahghs1 40 5 model model NN cord-309161-ceahghs1 40 6 can can MD cord-309161-ceahghs1 40 7 not not RB cord-309161-ceahghs1 40 8 determine determine VB cord-309161-ceahghs1 40 9 the the DT cord-309161-ceahghs1 40 10 exact exact JJ cord-309161-ceahghs1 40 11 parameters parameter NNS cord-309161-ceahghs1 40 12 of of IN cord-309161-ceahghs1 40 13 intensity intensity NN cord-309161-ceahghs1 40 14 and and CC cord-309161-ceahghs1 40 15 dose dose NN cord-309161-ceahghs1 40 16 for for IN cord-309161-ceahghs1 40 17 hormetic hormetic JJ cord-309161-ceahghs1 40 18 stressors stressor NNS cord-309161-ceahghs1 40 19 . . . cord-309161-ceahghs1 41 1 It -PRON- PRP cord-309161-ceahghs1 41 2 is be VBZ cord-309161-ceahghs1 41 3 important important JJ cord-309161-ceahghs1 41 4 area area NN cord-309161-ceahghs1 41 5 of of IN cord-309161-ceahghs1 41 6 future future JJ cord-309161-ceahghs1 41 7 research research NN cord-309161-ceahghs1 41 8 to to TO cord-309161-ceahghs1 41 9 identify identify VB cord-309161-ceahghs1 41 10 the the DT cord-309161-ceahghs1 41 11 boundary boundary JJ cord-309161-ceahghs1 41 12 conditions condition NNS cord-309161-ceahghs1 41 13 and and CC cord-309161-ceahghs1 41 14 inflection inflection NN cord-309161-ceahghs1 41 15 points point NNS cord-309161-ceahghs1 41 16 for for IN cord-309161-ceahghs1 41 17 the the DT cord-309161-ceahghs1 41 18 range range NN cord-309161-ceahghs1 41 19 of of IN cord-309161-ceahghs1 41 20 potentially potentially RB cord-309161-ceahghs1 41 21 hormetic hormetic JJ cord-309161-ceahghs1 41 22 stressors stressor NNS cord-309161-ceahghs1 41 23 . . . cord-309161-ceahghs1 42 1 Moderate moderate JJ cord-309161-ceahghs1 42 2 stressor stressor NN cord-309161-ceahghs1 42 3 exposure exposure NN cord-309161-ceahghs1 42 4 can can MD cord-309161-ceahghs1 42 5 lead lead VB cord-309161-ceahghs1 42 6 to to IN cord-309161-ceahghs1 42 7 both both DT cord-309161-ceahghs1 42 8 housecleaning housecleaning NN cord-309161-ceahghs1 42 9 in in IN cord-309161-ceahghs1 42 10 the the DT cord-309161-ceahghs1 42 11 cells cell NNS cord-309161-ceahghs1 42 12 , , , cord-309161-ceahghs1 42 13 making make VBG cord-309161-ceahghs1 42 14 them -PRON- PRP cord-309161-ceahghs1 42 15 appear appear VB cord-309161-ceahghs1 42 16 younger young JJR cord-309161-ceahghs1 42 17 or or CC cord-309161-ceahghs1 42 18 rejuvenated rejuvenate VBN cord-309161-ceahghs1 42 19 , , , cord-309161-ceahghs1 42 20 as as RB cord-309161-ceahghs1 42 21 well well RB cord-309161-ceahghs1 42 22 as as IN cord-309161-ceahghs1 42 23 growth growth NN cord-309161-ceahghs1 42 24 of of IN cord-309161-ceahghs1 42 25 new new JJ cord-309161-ceahghs1 42 26 neural neural JJ cord-309161-ceahghs1 42 27 pathways pathway NNS cord-309161-ceahghs1 42 28 . . . cord-309161-ceahghs1 43 1 Over over IN cord-309161-ceahghs1 43 2 time time NN cord-309161-ceahghs1 43 3 , , , cord-309161-ceahghs1 43 4 the the DT cord-309161-ceahghs1 43 5 accumulation accumulation NN cord-309161-ceahghs1 43 6 of of IN cord-309161-ceahghs1 43 7 hormetic hormetic JJ cord-309161-ceahghs1 43 8 stress stress NN cord-309161-ceahghs1 43 9 can can MD cord-309161-ceahghs1 43 10 promote promote VB cord-309161-ceahghs1 43 11 slowing slow VBG cord-309161-ceahghs1 43 12 of of IN cord-309161-ceahghs1 43 13 aging age VBG cord-309161-ceahghs1 43 14 processes process NNS cord-309161-ceahghs1 43 15 . . . cord-309161-ceahghs1 44 1 J J NNP cord-309161-ceahghs1 44 2 o o NN cord-309161-ceahghs1 44 3 u u NN cord-309161-ceahghs1 44 4 r r NN cord-309161-ceahghs1 44 5 n n NN cord-309161-ceahghs1 44 6 a a DT cord-309161-ceahghs1 44 7 l l NN cord-309161-ceahghs1 44 8 P p NN cord-309161-ceahghs1 44 9 r r NN cord-309161-ceahghs1 44 10 e e NN cord-309161-ceahghs1 44 11 -p -p NN cord-309161-ceahghs1 44 12 r r NN cord-309161-ceahghs1 44 13 o o NN cord-309161-ceahghs1 44 14 o o NN cord-309161-ceahghs1 45 1 f f LS cord-309161-ceahghs1 45 2 1.1 1.1 CD cord-309161-ceahghs1 45 3 Hormesis Hormesis NNP cord-309161-ceahghs1 45 4 is be VBZ cord-309161-ceahghs1 45 5 a a DT cord-309161-ceahghs1 45 6 form form NN cord-309161-ceahghs1 45 7 of of IN cord-309161-ceahghs1 45 8 stress stress NN cord-309161-ceahghs1 45 9 resilience resilience NN cord-309161-ceahghs1 45 10 . . . cord-309161-ceahghs1 46 1 This this DT cord-309161-ceahghs1 46 2 paper paper NN cord-309161-ceahghs1 46 3 brings bring VBZ cord-309161-ceahghs1 46 4 together together RB cord-309161-ceahghs1 46 5 the the DT cord-309161-ceahghs1 46 6 hormesis hormesis NN cord-309161-ceahghs1 46 7 literature literature NN cord-309161-ceahghs1 46 8 with with IN cord-309161-ceahghs1 46 9 the the DT cord-309161-ceahghs1 46 10 broader broad JJR cord-309161-ceahghs1 46 11 stress stress NN cord-309161-ceahghs1 46 12 resilience resilience NN cord-309161-ceahghs1 46 13 literature literature NN cord-309161-ceahghs1 46 14 . . . cord-309161-ceahghs1 47 1 The the DT cord-309161-ceahghs1 47 2 cellular cellular JJ cord-309161-ceahghs1 47 3 biology biology NN cord-309161-ceahghs1 47 4 of of IN cord-309161-ceahghs1 47 5 hormetic hormetic JJ cord-309161-ceahghs1 47 6 responses response NNS cord-309161-ceahghs1 47 7 is be VBZ cord-309161-ceahghs1 47 8 well well RB cord-309161-ceahghs1 47 9 mapped map VBN cord-309161-ceahghs1 47 10 , , , cord-309161-ceahghs1 47 11 and and CC cord-309161-ceahghs1 47 12 has have VBZ cord-309161-ceahghs1 47 13 general general JJ cord-309161-ceahghs1 47 14 common common JJ cord-309161-ceahghs1 47 15 responses response NNS cord-309161-ceahghs1 47 16 as as RB cord-309161-ceahghs1 47 17 well well RB cord-309161-ceahghs1 47 18 as as IN cord-309161-ceahghs1 47 19 stressor stressor NN cord-309161-ceahghs1 47 20 specific specific JJ cord-309161-ceahghs1 47 21 responses response NNS cord-309161-ceahghs1 47 22 . . . cord-309161-ceahghs1 48 1 The the DT cord-309161-ceahghs1 48 2 acute acute JJ cord-309161-ceahghs1 48 3 stress stress NN cord-309161-ceahghs1 48 4 response response NN cord-309161-ceahghs1 48 5 has have VBZ cord-309161-ceahghs1 48 6 a a DT cord-309161-ceahghs1 48 7 common common JJ cord-309161-ceahghs1 48 8 pathway pathway NN cord-309161-ceahghs1 48 9 of of IN cord-309161-ceahghs1 48 10 creating create VBG cord-309161-ceahghs1 48 11 calcium calcium NN cord-309161-ceahghs1 48 12 influx influx NN cord-309161-ceahghs1 48 13 , , , cord-309161-ceahghs1 48 14 oxidative oxidative JJ cord-309161-ceahghs1 48 15 stress stress NN cord-309161-ceahghs1 48 16 , , , cord-309161-ceahghs1 48 17 and and CC cord-309161-ceahghs1 48 18 energetic energetic JJ cord-309161-ceahghs1 48 19 stress stress NN cord-309161-ceahghs1 48 20 . . . cord-309161-ceahghs1 49 1 This this DT cord-309161-ceahghs1 49 2 increases increase VBZ cord-309161-ceahghs1 49 3 transcription transcription NN cord-309161-ceahghs1 49 4 factors factor NNS cord-309161-ceahghs1 49 5 such such JJ cord-309161-ceahghs1 49 6 as as IN cord-309161-ceahghs1 49 7 NRF-2 NRF-2 NNP cord-309161-ceahghs1 49 8 , , , cord-309161-ceahghs1 49 9 FOXOS FOXOS NNP cord-309161-ceahghs1 49 10 , , , cord-309161-ceahghs1 49 11 CREB CREB NNP cord-309161-ceahghs1 49 12 , , , cord-309161-ceahghs1 49 13 and and CC cord-309161-ceahghs1 49 14 NF NF NNP cord-309161-ceahghs1 49 15 - - HYPH cord-309161-ceahghs1 49 16 KB KB NNP cord-309161-ceahghs1 49 17 , , , cord-309161-ceahghs1 49 18 leading lead VBG cord-309161-ceahghs1 49 19 to to IN cord-309161-ceahghs1 49 20 many many JJ cord-309161-ceahghs1 49 21 hormetic hormetic JJ cord-309161-ceahghs1 49 22 effectors effector NNS cord-309161-ceahghs1 49 23 , , , cord-309161-ceahghs1 49 24 such such JJ cord-309161-ceahghs1 49 25 as as IN cord-309161-ceahghs1 49 26 chaperone chaperone NN cord-309161-ceahghs1 49 27 proteins protein NNS cord-309161-ceahghs1 49 28 ( ( -LRB- cord-309161-ceahghs1 49 29 eg eg RB cord-309161-ceahghs1 49 30 , , , cord-309161-ceahghs1 49 31 heat heat NN cord-309161-ceahghs1 49 32 shock shock NN cord-309161-ceahghs1 49 33 proteins protein NNS cord-309161-ceahghs1 49 34 which which WDT cord-309161-ceahghs1 49 35 help help VBP cord-309161-ceahghs1 49 36 fold fold VB cord-309161-ceahghs1 49 37 proteins protein NNS cord-309161-ceahghs1 49 38 efficiently efficiently RB cord-309161-ceahghs1 49 39 and and CC cord-309161-ceahghs1 49 40 prevent prevent VBP cord-309161-ceahghs1 49 41 protein protein NN cord-309161-ceahghs1 49 42 aggregation aggregation NN cord-309161-ceahghs1 49 43 ) ) -RRB- cord-309161-ceahghs1 49 44 , , , cord-309161-ceahghs1 49 45 ER ER NNP cord-309161-ceahghs1 49 46 stress stress NN cord-309161-ceahghs1 49 47 , , , cord-309161-ceahghs1 49 48 endogenous endogenous JJ cord-309161-ceahghs1 49 49 antioxidants antioxidant NNS cord-309161-ceahghs1 49 50 ( ( -LRB- cord-309161-ceahghs1 49 51 SOD SOD NNP cord-309161-ceahghs1 49 52 , , , cord-309161-ceahghs1 49 53 Glutathione Glutathione NNP cord-309161-ceahghs1 49 54 ) ) -RRB- cord-309161-ceahghs1 49 55 , , , cord-309161-ceahghs1 49 56 growth growth NN cord-309161-ceahghs1 49 57 factors factor NNS cord-309161-ceahghs1 49 58 , , , cord-309161-ceahghs1 49 59 and and CC cord-309161-ceahghs1 49 60 mitochondrial mitochondrial NN cord-309161-ceahghs1 49 61 proteins protein NNS cord-309161-ceahghs1 49 62 ( ( -LRB- cord-309161-ceahghs1 49 63 Mattson Mattson NNP cord-309161-ceahghs1 49 64 , , , cord-309161-ceahghs1 49 65 2008a 2008a CD cord-309161-ceahghs1 49 66 ) ) -RRB- cord-309161-ceahghs1 49 67 . . . cord-309161-ceahghs1 50 1 After after IN cord-309161-ceahghs1 50 2 moderate moderate JJ cord-309161-ceahghs1 50 3 doses dose NNS cord-309161-ceahghs1 50 4 , , , cord-309161-ceahghs1 50 5 the the DT cord-309161-ceahghs1 50 6 cells cell NNS cord-309161-ceahghs1 50 7 become become VBP cord-309161-ceahghs1 50 8 resistant resistant JJ cord-309161-ceahghs1 50 9 to to IN cord-309161-ceahghs1 50 10 many many JJ cord-309161-ceahghs1 50 11 other other JJ cord-309161-ceahghs1 50 12 types type NNS cord-309161-ceahghs1 50 13 of of IN cord-309161-ceahghs1 50 14 stressors stressor NNS cord-309161-ceahghs1 50 15 ( ( -LRB- cord-309161-ceahghs1 50 16 heat heat NN cord-309161-ceahghs1 50 17 , , , cord-309161-ceahghs1 50 18 UV uv NN cord-309161-ceahghs1 50 19 , , , cord-309161-ceahghs1 50 20 oxidative oxidative JJ cord-309161-ceahghs1 50 21 stress stress NN cord-309161-ceahghs1 50 22 , , , cord-309161-ceahghs1 50 23 metals metal NNS cord-309161-ceahghs1 50 24 ) ) -RRB- cord-309161-ceahghs1 50 25 , , , cord-309161-ceahghs1 50 26 and and CC cord-309161-ceahghs1 50 27 to to IN cord-309161-ceahghs1 50 28 death death NN cord-309161-ceahghs1 50 29 ( ( -LRB- cord-309161-ceahghs1 50 30 Murakami Murakami NNP cord-309161-ceahghs1 50 31 et et FW cord-309161-ceahghs1 50 32 al al NNP cord-309161-ceahghs1 50 33 . . NNP cord-309161-ceahghs1 50 34 , , , cord-309161-ceahghs1 50 35 2003 2003 CD cord-309161-ceahghs1 50 36 ) ) -RRB- cord-309161-ceahghs1 50 37 . . . cord-309161-ceahghs1 51 1 Hormesis hormesis NN cord-309161-ceahghs1 51 2 is be VBZ cord-309161-ceahghs1 51 3 a a DT cord-309161-ceahghs1 51 4 universally universally RB cord-309161-ceahghs1 51 5 observed observed JJ cord-309161-ceahghs1 51 6 phenomena phenomena JJ cord-309161-ceahghs1 51 7 across across IN cord-309161-ceahghs1 51 8 types type NNS cord-309161-ceahghs1 51 9 of of IN cord-309161-ceahghs1 51 10 cells cell NNS cord-309161-ceahghs1 51 11 and and CC cord-309161-ceahghs1 51 12 types type NNS cord-309161-ceahghs1 51 13 of of IN cord-309161-ceahghs1 51 14 stressors stressor NNS cord-309161-ceahghs1 51 15 , , , cord-309161-ceahghs1 51 16 including include VBG cord-309161-ceahghs1 51 17 psychological psychological JJ cord-309161-ceahghs1 51 18 stress stress NN cord-309161-ceahghs1 51 19 . . . cord-309161-ceahghs1 52 1 In in IN cord-309161-ceahghs1 52 2 model model NN cord-309161-ceahghs1 52 3 organisms organism NNS cord-309161-ceahghs1 52 4 , , , cord-309161-ceahghs1 52 5 short short JJ cord-309161-ceahghs1 52 6 manageable manageable JJ cord-309161-ceahghs1 52 7 stressors stressor NNS cord-309161-ceahghs1 52 8 lead lead VBP cord-309161-ceahghs1 52 9 to to IN cord-309161-ceahghs1 52 10 improvements improvement NNS cord-309161-ceahghs1 52 11 in in IN cord-309161-ceahghs1 52 12 aging age VBG cord-309161-ceahghs1 52 13 , , , cord-309161-ceahghs1 52 14 although although IN cord-309161-ceahghs1 52 15 this this DT cord-309161-ceahghs1 52 16 depends depend VBZ cord-309161-ceahghs1 52 17 on on IN cord-309161-ceahghs1 52 18 types type NNS cord-309161-ceahghs1 52 19 of of IN cord-309161-ceahghs1 52 20 stressor stressor NN cord-309161-ceahghs1 52 21 and and CC cord-309161-ceahghs1 52 22 species specie NNS cord-309161-ceahghs1 52 23 ( ( -LRB- cord-309161-ceahghs1 52 24 Lagisz Lagisz NNP cord-309161-ceahghs1 52 25 et et NNP cord-309161-ceahghs1 52 26 al al NNP cord-309161-ceahghs1 52 27 . . NNP cord-309161-ceahghs1 52 28 , , , cord-309161-ceahghs1 52 29 2013 2013 CD cord-309161-ceahghs1 52 30 ; ; : cord-309161-ceahghs1 52 31 Rattan Rattan NNP cord-309161-ceahghs1 52 32 , , , cord-309161-ceahghs1 52 33 2008 2008 CD cord-309161-ceahghs1 52 34 ) ) -RRB- cord-309161-ceahghs1 52 35 . . . cord-309161-ceahghs1 53 1 For for IN cord-309161-ceahghs1 53 2 example example NN cord-309161-ceahghs1 53 3 , , , cord-309161-ceahghs1 53 4 low low JJ cord-309161-ceahghs1 53 5 dose dose NN cord-309161-ceahghs1 53 6 gamma gamma NN cord-309161-ceahghs1 53 7 radiation radiation NN cord-309161-ceahghs1 53 8 over over IN cord-309161-ceahghs1 53 9 time time NN cord-309161-ceahghs1 53 10 can can MD cord-309161-ceahghs1 53 11 extend extend VB cord-309161-ceahghs1 53 12 average average JJ cord-309161-ceahghs1 53 13 lifespan lifespan NN cord-309161-ceahghs1 53 14 up up IN cord-309161-ceahghs1 53 15 to to TO cord-309161-ceahghs1 53 16 30 30 CD cord-309161-ceahghs1 53 17 % % NN cord-309161-ceahghs1 53 18 in in IN cord-309161-ceahghs1 53 19 mouse mouse NN cord-309161-ceahghs1 53 20 studies study NNS cord-309161-ceahghs1 53 21 ( ( -LRB- cord-309161-ceahghs1 53 22 Calabrese Calabrese NNP cord-309161-ceahghs1 53 23 & & CC cord-309161-ceahghs1 53 24 Baldwin Baldwin NNP cord-309161-ceahghs1 53 25 , , , cord-309161-ceahghs1 53 26 2000 2000 CD cord-309161-ceahghs1 53 27 ) ) -RRB- cord-309161-ceahghs1 53 28 . . . cord-309161-ceahghs1 54 1 In in IN cord-309161-ceahghs1 54 2 humans human NNS cord-309161-ceahghs1 54 3 , , , cord-309161-ceahghs1 54 4 there there EX cord-309161-ceahghs1 54 5 is be VBZ cord-309161-ceahghs1 54 6 evidence evidence NN cord-309161-ceahghs1 54 7 of of IN cord-309161-ceahghs1 54 8 hormetic hormetic JJ cord-309161-ceahghs1 54 9 stress stress NN cord-309161-ceahghs1 54 10 , , , cord-309161-ceahghs1 54 11 such such JJ cord-309161-ceahghs1 54 12 as as IN cord-309161-ceahghs1 54 13 the the DT cord-309161-ceahghs1 54 14 effects effect NNS cord-309161-ceahghs1 54 15 of of IN cord-309161-ceahghs1 54 16 exercise exercise NN cord-309161-ceahghs1 54 17 , , , cord-309161-ceahghs1 54 18 although although IN cord-309161-ceahghs1 54 19 this this DT cord-309161-ceahghs1 54 20 is be VBZ cord-309161-ceahghs1 54 21 not not RB cord-309161-ceahghs1 54 22 typically typically RB cord-309161-ceahghs1 54 23 labeled label VBN cord-309161-ceahghs1 54 24 as as IN cord-309161-ceahghs1 54 25 hormesis hormesis NN cord-309161-ceahghs1 54 26 . . . cord-309161-ceahghs1 55 1 Hormesis Hormesis NNP cord-309161-ceahghs1 55 2 naturally naturally RB cord-309161-ceahghs1 55 3 applies apply VBZ cord-309161-ceahghs1 55 4 to to IN cord-309161-ceahghs1 55 5 humans human NNS cord-309161-ceahghs1 55 6 - - : cord-309161-ceahghs1 55 7 not not RB cord-309161-ceahghs1 55 8 just just RB cord-309161-ceahghs1 55 9 to to IN cord-309161-ceahghs1 55 10 cells cell NNS cord-309161-ceahghs1 55 11 but but CC cord-309161-ceahghs1 55 12 to to IN cord-309161-ceahghs1 55 13 physiological physiological JJ cord-309161-ceahghs1 55 14 and and CC cord-309161-ceahghs1 55 15 psychological psychological JJ cord-309161-ceahghs1 55 16 regulation regulation NN cord-309161-ceahghs1 55 17 . . . cord-309161-ceahghs1 56 1 A a DT cord-309161-ceahghs1 56 2 typical typical JJ cord-309161-ceahghs1 56 3 example example NN cord-309161-ceahghs1 56 4 is be VBZ cord-309161-ceahghs1 56 5 vaccinationwhich vaccinationwhich NN cord-309161-ceahghs1 56 6 leads lead VBZ cord-309161-ceahghs1 56 7 to to IN cord-309161-ceahghs1 56 8 enhanced enhanced JJ cord-309161-ceahghs1 56 9 immune immune JJ cord-309161-ceahghs1 56 10 responses response NNS cord-309161-ceahghs1 56 11 later later RB cord-309161-ceahghs1 56 12 . . . cord-309161-ceahghs1 57 1 Here here RB cord-309161-ceahghs1 57 2 we -PRON- PRP cord-309161-ceahghs1 57 3 expand expand VBP cord-309161-ceahghs1 57 4 the the DT cord-309161-ceahghs1 57 5 definition definition NN cord-309161-ceahghs1 57 6 of of IN cord-309161-ceahghs1 57 7 hormetic hormetic JJ cord-309161-ceahghs1 57 8 stress stress NN cord-309161-ceahghs1 57 9 to to TO cord-309161-ceahghs1 57 10 include include VB cord-309161-ceahghs1 57 11 the the DT cord-309161-ceahghs1 57 12 positive positive JJ cord-309161-ceahghs1 57 13 stressors stressor NNS cord-309161-ceahghs1 57 14 that that WDT cord-309161-ceahghs1 57 15 humans human NNS cord-309161-ceahghs1 57 16 engage engage VBP cord-309161-ceahghs1 57 17 in in IN cord-309161-ceahghs1 57 18 - - HYPH cord-309161-ceahghs1 57 19 such such JJ cord-309161-ceahghs1 57 20 as as IN cord-309161-ceahghs1 57 21 short short JJ cord-309161-ceahghs1 57 22 term term NN cord-309161-ceahghs1 57 23 bodily bodily JJ cord-309161-ceahghs1 57 24 stressors stressor NNS cord-309161-ceahghs1 57 25 like like IN cord-309161-ceahghs1 57 26 exercise exercise NN cord-309161-ceahghs1 57 27 and and CC cord-309161-ceahghs1 57 28 temperature temperature NN cord-309161-ceahghs1 57 29 stress stress NN cord-309161-ceahghs1 57 30 , , , cord-309161-ceahghs1 57 31 but but CC cord-309161-ceahghs1 57 32 also also RB cord-309161-ceahghs1 57 33 novel novel JJ cord-309161-ceahghs1 57 34 challenging challenging JJ cord-309161-ceahghs1 57 35 experiences experience NNS cord-309161-ceahghs1 57 36 that that WDT cord-309161-ceahghs1 57 37 expand expand VBP cord-309161-ceahghs1 57 38 coping cope VBG cord-309161-ceahghs1 57 39 resources resource NNS cord-309161-ceahghs1 57 40 , , , cord-309161-ceahghs1 57 41 knowledge knowledge NN cord-309161-ceahghs1 57 42 , , , cord-309161-ceahghs1 57 43 generativity generativity NN cord-309161-ceahghs1 57 44 , , , cord-309161-ceahghs1 57 45 and and CC cord-309161-ceahghs1 57 46 feelings feeling NNS cord-309161-ceahghs1 57 47 of of IN cord-309161-ceahghs1 57 48 accomplishment accomplishment NN cord-309161-ceahghs1 57 49 , , , cord-309161-ceahghs1 57 50 described describe VBN cord-309161-ceahghs1 57 51 further further RB cord-309161-ceahghs1 57 52 below below RB cord-309161-ceahghs1 57 53 ( ( -LRB- cord-309161-ceahghs1 57 54 Section section NN cord-309161-ceahghs1 57 55 1.2 1.2 CD cord-309161-ceahghs1 57 56 ) ) -RRB- cord-309161-ceahghs1 57 57 . . . cord-309161-ceahghs1 58 1 Since since IN cord-309161-ceahghs1 58 2 hormetic hormetic JJ cord-309161-ceahghs1 58 3 stress stress NN cord-309161-ceahghs1 58 4 has have VBZ cord-309161-ceahghs1 58 5 traditionally traditionally RB cord-309161-ceahghs1 58 6 been be VBN cord-309161-ceahghs1 58 7 applied apply VBN cord-309161-ceahghs1 58 8 to to IN cord-309161-ceahghs1 58 9 cellular cellular JJ cord-309161-ceahghs1 58 10 physiology physiology NN cord-309161-ceahghs1 58 11 , , , cord-309161-ceahghs1 58 12 we -PRON- PRP cord-309161-ceahghs1 58 13 use use VBP cord-309161-ceahghs1 58 14 the the DT cord-309161-ceahghs1 58 15 larger large JJR cord-309161-ceahghs1 58 16 concept concept NN cord-309161-ceahghs1 58 17 of of IN cord-309161-ceahghs1 58 18 ' ' `` cord-309161-ceahghs1 58 19 stress stress NN cord-309161-ceahghs1 58 20 resilience resilience NN cord-309161-ceahghs1 58 21 ' ' '' cord-309161-ceahghs1 58 22 as as IN cord-309161-ceahghs1 58 23 the the DT cord-309161-ceahghs1 58 24 widest wide JJS cord-309161-ceahghs1 58 25 umbrella umbrella NN cord-309161-ceahghs1 58 26 term term NN cord-309161-ceahghs1 58 27 for for IN cord-309161-ceahghs1 58 28 describing describe VBG cord-309161-ceahghs1 58 29 when when WRB cord-309161-ceahghs1 58 30 humans human NNS cord-309161-ceahghs1 58 31 recover recover VBP cord-309161-ceahghs1 58 32 quickly quickly RB cord-309161-ceahghs1 58 33 , , , cord-309161-ceahghs1 58 34 in in IN cord-309161-ceahghs1 58 35 any any DT cord-309161-ceahghs1 58 36 system system NN cord-309161-ceahghs1 58 37 , , , cord-309161-ceahghs1 58 38 from from IN cord-309161-ceahghs1 58 39 various various JJ cord-309161-ceahghs1 58 40 exposures exposure NNS cord-309161-ceahghs1 58 41 . . . cord-309161-ceahghs1 59 1 As as IN cord-309161-ceahghs1 59 2 shown show VBN cord-309161-ceahghs1 59 3 in in IN cord-309161-ceahghs1 59 4 the the DT cord-309161-ceahghs1 59 5 Appendix Appendix NNP cord-309161-ceahghs1 59 6 , , , cord-309161-ceahghs1 59 7 there there EX cord-309161-ceahghs1 59 8 are be VBP cord-309161-ceahghs1 59 9 many many JJ cord-309161-ceahghs1 59 10 J J NNP cord-309161-ceahghs1 59 11 o o NN cord-309161-ceahghs1 59 12 u u NN cord-309161-ceahghs1 59 13 r r NN cord-309161-ceahghs1 59 14 n n NN cord-309161-ceahghs1 59 15 a a DT cord-309161-ceahghs1 59 16 l l NN cord-309161-ceahghs1 59 17 P p NN cord-309161-ceahghs1 59 18 r r NN cord-309161-ceahghs1 59 19 e e NN cord-309161-ceahghs1 59 20 -p -p NN cord-309161-ceahghs1 59 21 r r NN cord-309161-ceahghs1 59 22 o o NN cord-309161-ceahghs1 59 23 o o NN cord-309161-ceahghs1 59 24 f f NN cord-309161-ceahghs1 59 25 overlapping overlap VBG cord-309161-ceahghs1 59 26 terms term NNS cord-309161-ceahghs1 59 27 that that WDT cord-309161-ceahghs1 59 28 relate relate VBP cord-309161-ceahghs1 59 29 to to IN cord-309161-ceahghs1 59 30 the the DT cord-309161-ceahghs1 59 31 concept concept NN cord-309161-ceahghs1 59 32 of of IN cord-309161-ceahghs1 59 33 stress stress NN cord-309161-ceahghs1 59 34 resilience resilience NN cord-309161-ceahghs1 59 35 . . . cord-309161-ceahghs1 60 1 Just just RB cord-309161-ceahghs1 60 2 as as IN cord-309161-ceahghs1 60 3 the the DT cord-309161-ceahghs1 60 4 term term NN cord-309161-ceahghs1 60 5 " " `` cord-309161-ceahghs1 60 6 stress stress NN cord-309161-ceahghs1 60 7 " " '' cord-309161-ceahghs1 60 8 is be VBZ cord-309161-ceahghs1 60 9 a a DT cord-309161-ceahghs1 60 10 multi multi JJ cord-309161-ceahghs1 60 11 - - JJ cord-309161-ceahghs1 60 12 level level JJ cord-309161-ceahghs1 60 13 construct construct NN cord-309161-ceahghs1 60 14 that that WDT cord-309161-ceahghs1 60 15 needs need VBZ cord-309161-ceahghs1 60 16 to to TO cord-309161-ceahghs1 60 17 examination examination VB cord-309161-ceahghs1 60 18 in in IN cord-309161-ceahghs1 60 19 a a DT cord-309161-ceahghs1 60 20 sophisticated sophisticated JJ cord-309161-ceahghs1 60 21 interdisciplinary interdisciplinary JJ cord-309161-ceahghs1 60 22 manner manner NN cord-309161-ceahghs1 60 23 , , , cord-309161-ceahghs1 60 24 stress stress NN cord-309161-ceahghs1 60 25 resilience resilience NN cord-309161-ceahghs1 60 26 is be VBZ cord-309161-ceahghs1 60 27 also also RB cord-309161-ceahghs1 60 28 a a DT cord-309161-ceahghs1 60 29 multi multi JJ cord-309161-ceahghs1 60 30 - - JJ cord-309161-ceahghs1 60 31 level level JJ cord-309161-ceahghs1 60 32 concept concept NN cord-309161-ceahghs1 60 33 that that WDT cord-309161-ceahghs1 60 34 encompasses encompass VBZ cord-309161-ceahghs1 60 35 the the DT cord-309161-ceahghs1 60 36 full full JJ cord-309161-ceahghs1 60 37 range range NN cord-309161-ceahghs1 60 38 of of IN cord-309161-ceahghs1 60 39 human human JJ cord-309161-ceahghs1 60 40 exposures exposure NNS cord-309161-ceahghs1 60 41 , , , cord-309161-ceahghs1 60 42 responses response NNS cord-309161-ceahghs1 60 43 , , , cord-309161-ceahghs1 60 44 and and CC cord-309161-ceahghs1 60 45 inter inter JJ cord-309161-ceahghs1 60 46 - - JJ cord-309161-ceahghs1 60 47 related related JJ cord-309161-ceahghs1 60 48 systems system NNS cord-309161-ceahghs1 60 49 . . . cord-309161-ceahghs1 61 1 The the DT cord-309161-ceahghs1 61 2 term term NN cord-309161-ceahghs1 61 3 stress stress NN cord-309161-ceahghs1 61 4 resilience resilience NN cord-309161-ceahghs1 61 5 thus thus RB cord-309161-ceahghs1 61 6 subsumes subsume VBZ cord-309161-ceahghs1 61 7 psychological psychological JJ cord-309161-ceahghs1 61 8 resilience resilience NN cord-309161-ceahghs1 61 9 , , , cord-309161-ceahghs1 61 10 physiological physiological JJ cord-309161-ceahghs1 61 11 resilience resilience NN cord-309161-ceahghs1 61 12 / / SYM cord-309161-ceahghs1 61 13 enhanced enhance VBN cord-309161-ceahghs1 61 14 allostasis allostasis NNP cord-309161-ceahghs1 61 15 , , , cord-309161-ceahghs1 61 16 and and CC cord-309161-ceahghs1 61 17 social social JJ cord-309161-ceahghs1 61 18 resilience resilience NN cord-309161-ceahghs1 61 19 . . . cord-309161-ceahghs1 62 1 This this DT cord-309161-ceahghs1 62 2 model model NN cord-309161-ceahghs1 62 3 of of IN cord-309161-ceahghs1 62 4 stress stress NN cord-309161-ceahghs1 62 5 resilience resilience NN cord-309161-ceahghs1 62 6 can can MD cord-309161-ceahghs1 62 7 thus thus RB cord-309161-ceahghs1 62 8 be be VB cord-309161-ceahghs1 62 9 applied apply VBN cord-309161-ceahghs1 62 10 to to IN cord-309161-ceahghs1 62 11 most most JJS cord-309161-ceahghs1 62 12 processes process NNS cord-309161-ceahghs1 62 13 -- -- : cord-309161-ceahghs1 62 14 at at IN cord-309161-ceahghs1 62 15 the the DT cord-309161-ceahghs1 62 16 cellular cellular JJ cord-309161-ceahghs1 62 17 level level NN cord-309161-ceahghs1 62 18 , , , cord-309161-ceahghs1 62 19 physiological physiological JJ cord-309161-ceahghs1 62 20 level level NN cord-309161-ceahghs1 62 21 , , , cord-309161-ceahghs1 62 22 and and CC cord-309161-ceahghs1 62 23 psychosocial psychosocial JJ cord-309161-ceahghs1 62 24 level level NN cord-309161-ceahghs1 62 25 . . . cord-309161-ceahghs1 63 1 Psychosocial psychosocial JJ cord-309161-ceahghs1 63 2 stress stress NN cord-309161-ceahghs1 63 3 resilience resilience NN cord-309161-ceahghs1 63 4 here here RB cord-309161-ceahghs1 63 5 refers refer VBZ cord-309161-ceahghs1 63 6 to to IN cord-309161-ceahghs1 63 7 the the DT cord-309161-ceahghs1 63 8 dynamic dynamic JJ cord-309161-ceahghs1 63 9 recovery recovery NN cord-309161-ceahghs1 63 10 in in IN cord-309161-ceahghs1 63 11 psychological psychological JJ cord-309161-ceahghs1 63 12 , , , cord-309161-ceahghs1 63 13 behavioral behavioral JJ cord-309161-ceahghs1 63 14 and and CC cord-309161-ceahghs1 63 15 social social JJ cord-309161-ceahghs1 63 16 processes process NNS cord-309161-ceahghs1 63 17 and and CC cord-309161-ceahghs1 63 18 related related JJ cord-309161-ceahghs1 63 19 physiological physiological JJ cord-309161-ceahghs1 63 20 processes process NNS cord-309161-ceahghs1 63 21 . . . cord-309161-ceahghs1 64 1 High high JJ cord-309161-ceahghs1 64 2 stress stress NN cord-309161-ceahghs1 64 3 resilience resilience NN cord-309161-ceahghs1 64 4 is be VBZ cord-309161-ceahghs1 64 5 reflected reflect VBN cord-309161-ceahghs1 64 6 by by IN cord-309161-ceahghs1 64 7 quick quick JJ cord-309161-ceahghs1 64 8 physiological physiological JJ cord-309161-ceahghs1 64 9 and and CC cord-309161-ceahghs1 64 10 affective affective JJ cord-309161-ceahghs1 64 11 recovery recovery NN cord-309161-ceahghs1 64 12 from from IN cord-309161-ceahghs1 64 13 psychological psychological JJ cord-309161-ceahghs1 64 14 stressors stressor NNS cord-309161-ceahghs1 64 15 . . . cord-309161-ceahghs1 65 1 The the DT cord-309161-ceahghs1 65 2 neurochemistry neurochemistry NN cord-309161-ceahghs1 65 3 of of IN cord-309161-ceahghs1 65 4 psychological psychological JJ cord-309161-ceahghs1 65 5 resilience resilience NN cord-309161-ceahghs1 65 6 has have VBZ cord-309161-ceahghs1 65 7 also also RB cord-309161-ceahghs1 65 8 been be VBN cord-309161-ceahghs1 65 9 described describe VBN cord-309161-ceahghs1 65 10 , , , cord-309161-ceahghs1 65 11 based base VBN cord-309161-ceahghs1 65 12 on on IN cord-309161-ceahghs1 65 13 rodent rodent NN cord-309161-ceahghs1 65 14 models model NNS cord-309161-ceahghs1 65 15 ( ( -LRB- cord-309161-ceahghs1 65 16 Cathomas Cathomas NNP cord-309161-ceahghs1 65 17 et et NNP cord-309161-ceahghs1 65 18 al al NNP cord-309161-ceahghs1 65 19 . . NNP cord-309161-ceahghs1 65 20 , , , cord-309161-ceahghs1 65 21 2019 2019 CD cord-309161-ceahghs1 65 22 ) ) -RRB- cord-309161-ceahghs1 65 23 . . . cord-309161-ceahghs1 66 1 Whether whether IN cord-309161-ceahghs1 66 2 a a DT cord-309161-ceahghs1 66 3 stressor stressor NN cord-309161-ceahghs1 66 4 leads lead VBZ cord-309161-ceahghs1 66 5 to to IN cord-309161-ceahghs1 66 6 a a DT cord-309161-ceahghs1 66 7 hormetic hormetic JJ cord-309161-ceahghs1 66 8 or or CC cord-309161-ceahghs1 66 9 toxic toxic JJ cord-309161-ceahghs1 66 10 response response NN cord-309161-ceahghs1 66 11 is be VBZ cord-309161-ceahghs1 66 12 not not RB cord-309161-ceahghs1 66 13 solely solely RB cord-309161-ceahghs1 66 14 determined determine VBN cord-309161-ceahghs1 66 15 by by IN cord-309161-ceahghs1 66 16 the the DT cord-309161-ceahghs1 66 17 chronicity chronicity NN cord-309161-ceahghs1 66 18 of of IN cord-309161-ceahghs1 66 19 the the DT cord-309161-ceahghs1 66 20 stressor stressor NN cord-309161-ceahghs1 66 21 . . . cord-309161-ceahghs1 67 1 It -PRON- PRP cord-309161-ceahghs1 67 2 is be VBZ cord-309161-ceahghs1 67 3 also also RB cord-309161-ceahghs1 67 4 determined determine VBN cord-309161-ceahghs1 67 5 in in IN cord-309161-ceahghs1 67 6 part part NN cord-309161-ceahghs1 67 7 by by IN cord-309161-ceahghs1 67 8 the the DT cord-309161-ceahghs1 67 9 psychological psychological JJ cord-309161-ceahghs1 67 10 appraisals appraisal NNS cord-309161-ceahghs1 67 11 , , , cord-309161-ceahghs1 67 12 which which WDT cord-309161-ceahghs1 67 13 is be VBZ cord-309161-ceahghs1 67 14 shaped shape VBN cord-309161-ceahghs1 67 15 by by IN cord-309161-ceahghs1 67 16 the the DT cord-309161-ceahghs1 67 17 context context NN cord-309161-ceahghs1 67 18 , , , cord-309161-ceahghs1 67 19 culture culture NN cord-309161-ceahghs1 67 20 , , , cord-309161-ceahghs1 67 21 personal personal JJ cord-309161-ceahghs1 67 22 history history NN cord-309161-ceahghs1 67 23 and and CC cord-309161-ceahghs1 67 24 personality personality NN cord-309161-ceahghs1 67 25 of of IN cord-309161-ceahghs1 67 26 the the DT cord-309161-ceahghs1 67 27 individual individual NN cord-309161-ceahghs1 67 28 . . . cord-309161-ceahghs1 68 1 When when WRB cord-309161-ceahghs1 68 2 one one PRP cord-309161-ceahghs1 68 3 feels feel VBZ cord-309161-ceahghs1 68 4 demands demand NNS cord-309161-ceahghs1 68 5 exceed exceed VBP cord-309161-ceahghs1 68 6 resources resource NNS cord-309161-ceahghs1 68 7 , , , cord-309161-ceahghs1 68 8 in in IN cord-309161-ceahghs1 68 9 any any DT cord-309161-ceahghs1 68 10 situation situation NN cord-309161-ceahghs1 68 11 , , , cord-309161-ceahghs1 68 12 this this DT cord-309161-ceahghs1 68 13 creates create VBZ cord-309161-ceahghs1 68 14 a a DT cord-309161-ceahghs1 68 15 physiological physiological JJ cord-309161-ceahghs1 68 16 and and CC cord-309161-ceahghs1 68 17 emotional emotional JJ cord-309161-ceahghs1 68 18 stress stress NN cord-309161-ceahghs1 68 19 response response NN cord-309161-ceahghs1 68 20 ( ( -LRB- cord-309161-ceahghs1 68 21 Folkman Folkman NNP cord-309161-ceahghs1 68 22 et et NNP cord-309161-ceahghs1 68 23 al al NNP cord-309161-ceahghs1 68 24 . . NNP cord-309161-ceahghs1 68 25 , , , cord-309161-ceahghs1 68 26 1986 1986 CD cord-309161-ceahghs1 68 27 ) ) -RRB- cord-309161-ceahghs1 68 28 . . . cord-309161-ceahghs1 69 1 If if IN cord-309161-ceahghs1 69 2 it -PRON- PRP cord-309161-ceahghs1 69 3 is be VBZ cord-309161-ceahghs1 69 4 perceived perceive VBN cord-309161-ceahghs1 69 5 as as IN cord-309161-ceahghs1 69 6 a a DT cord-309161-ceahghs1 69 7 threat threat NN cord-309161-ceahghs1 69 8 they -PRON- PRP cord-309161-ceahghs1 69 9 can can MD cord-309161-ceahghs1 69 10 not not RB cord-309161-ceahghs1 69 11 cope cope VB cord-309161-ceahghs1 69 12 with with IN cord-309161-ceahghs1 69 13 , , , cord-309161-ceahghs1 69 14 this this DT cord-309161-ceahghs1 69 15 repeated repeat VBN cord-309161-ceahghs1 69 16 stress stress NN cord-309161-ceahghs1 69 17 response response NN cord-309161-ceahghs1 69 18 over over IN cord-309161-ceahghs1 69 19 time time NN cord-309161-ceahghs1 69 20 will will MD cord-309161-ceahghs1 69 21 last last VB cord-309161-ceahghs1 69 22 longer long RBR cord-309161-ceahghs1 69 23 and and CC cord-309161-ceahghs1 69 24 be be VB cord-309161-ceahghs1 69 25 more more JJR cord-309161-ceahghs1 69 26 wearing wear VBG cord-309161-ceahghs1 69 27 . . . cord-309161-ceahghs1 70 1 In in IN cord-309161-ceahghs1 70 2 contrast contrast NN cord-309161-ceahghs1 70 3 , , , cord-309161-ceahghs1 70 4 if if IN cord-309161-ceahghs1 70 5 they -PRON- PRP cord-309161-ceahghs1 70 6 view view VBP cord-309161-ceahghs1 70 7 it -PRON- PRP cord-309161-ceahghs1 70 8 as as IN cord-309161-ceahghs1 70 9 positive positive JJ cord-309161-ceahghs1 70 10 challenge challenge NN cord-309161-ceahghs1 70 11 that that WDT cord-309161-ceahghs1 70 12 they -PRON- PRP cord-309161-ceahghs1 70 13 have have VBP cord-309161-ceahghs1 70 14 the the DT cord-309161-ceahghs1 70 15 resources resource NNS cord-309161-ceahghs1 70 16 for for IN cord-309161-ceahghs1 70 17 , , , cord-309161-ceahghs1 70 18 they -PRON- PRP cord-309161-ceahghs1 70 19 will will MD cord-309161-ceahghs1 70 20 have have VB cord-309161-ceahghs1 70 21 a a DT cord-309161-ceahghs1 70 22 profile profile NN cord-309161-ceahghs1 70 23 of of IN cord-309161-ceahghs1 70 24 quicker quick JJR cord-309161-ceahghs1 70 25 recovery recovery NN cord-309161-ceahghs1 70 26 , , , cord-309161-ceahghs1 70 27 as as IN cord-309161-ceahghs1 70 28 summarized summarize VBN cord-309161-ceahghs1 70 29 elsewhere elsewhere RB cord-309161-ceahghs1 70 30 . . . cord-309161-ceahghs1 71 1 Thus thus RB cord-309161-ceahghs1 71 2 the the DT cord-309161-ceahghs1 71 3 appraisal appraisal NN cord-309161-ceahghs1 71 4 of of IN cord-309161-ceahghs1 71 5 the the DT cord-309161-ceahghs1 71 6 stressor stressor NN cord-309161-ceahghs1 71 7 codetermines codetermine VBZ cord-309161-ceahghs1 71 8 the the DT cord-309161-ceahghs1 71 9 physiological physiological JJ cord-309161-ceahghs1 71 10 response response NN cord-309161-ceahghs1 71 11 . . . cord-309161-ceahghs1 72 1 It -PRON- PRP cord-309161-ceahghs1 72 2 is be VBZ cord-309161-ceahghs1 72 3 not not RB cord-309161-ceahghs1 72 4 just just RB cord-309161-ceahghs1 72 5 stress stress NN cord-309161-ceahghs1 72 6 responses response NNS cord-309161-ceahghs1 72 7 to to IN cord-309161-ceahghs1 72 8 major major JJ cord-309161-ceahghs1 72 9 events event NNS cord-309161-ceahghs1 72 10 that that WDT cord-309161-ceahghs1 72 11 matter matter VBP cord-309161-ceahghs1 72 12 . . . cord-309161-ceahghs1 73 1 Our -PRON- PRP$ cord-309161-ceahghs1 73 2 frequent frequent JJ cord-309161-ceahghs1 73 3 daily daily JJ cord-309161-ceahghs1 73 4 stress stress NN cord-309161-ceahghs1 73 5 responses response NNS cord-309161-ceahghs1 73 6 have have VBP cord-309161-ceahghs1 73 7 cumulative cumulative JJ cord-309161-ceahghs1 73 8 effects effect NNS cord-309161-ceahghs1 73 9 : : : cord-309161-ceahghs1 73 10 The the DT cord-309161-ceahghs1 73 11 tendency tendency NN cord-309161-ceahghs1 73 12 to to TO cord-309161-ceahghs1 73 13 have have VB cord-309161-ceahghs1 73 14 slower slow JJR cord-309161-ceahghs1 73 15 recovery recovery NN cord-309161-ceahghs1 73 16 of of IN cord-309161-ceahghs1 73 17 negative negative JJ cord-309161-ceahghs1 73 18 mood mood NN cord-309161-ceahghs1 73 19 or or CC cord-309161-ceahghs1 73 20 greater great JJR cord-309161-ceahghs1 73 21 loss loss NN cord-309161-ceahghs1 73 22 of of IN cord-309161-ceahghs1 73 23 positive positive JJ cord-309161-ceahghs1 73 24 mood mood NN cord-309161-ceahghs1 73 25 after after IN cord-309161-ceahghs1 73 26 a a DT cord-309161-ceahghs1 73 27 daily daily JJ cord-309161-ceahghs1 73 28 stressor stressor NN cord-309161-ceahghs1 73 29 predicts predict VBZ cord-309161-ceahghs1 73 30 inflammation inflammation NN cord-309161-ceahghs1 73 31 and and CC cord-309161-ceahghs1 73 32 long long JJ cord-309161-ceahghs1 73 33 term term NN cord-309161-ceahghs1 73 34 disease disease NN cord-309161-ceahghs1 73 35 and and CC cord-309161-ceahghs1 73 36 mortality mortality NN cord-309161-ceahghs1 74 1 Mroczek Mroczek NNP cord-309161-ceahghs1 74 2 et et NNP cord-309161-ceahghs1 74 3 al al NNP cord-309161-ceahghs1 74 4 . . . cord-309161-ceahghs1 75 1 , , , cord-309161-ceahghs1 75 2 2015 2015 CD cord-309161-ceahghs1 75 3 ; ; : cord-309161-ceahghs1 75 4 Piazza Piazza NNP cord-309161-ceahghs1 75 5 et et FW cord-309161-ceahghs1 75 6 al al NNP cord-309161-ceahghs1 75 7 . . NNP cord-309161-ceahghs1 75 8 , , , cord-309161-ceahghs1 75 9 2013 2013 CD cord-309161-ceahghs1 75 10 ; ; : cord-309161-ceahghs1 76 1 Sin sin NN cord-309161-ceahghs1 76 2 et et NNP cord-309161-ceahghs1 76 3 al al NNP cord-309161-ceahghs1 76 4 . . NNP cord-309161-ceahghs1 76 5 , , , cord-309161-ceahghs1 76 6 2015 2015 CD cord-309161-ceahghs1 76 7 ) ) -RRB- cord-309161-ceahghs1 76 8 . . . cord-309161-ceahghs1 77 1 Short short JJ cord-309161-ceahghs1 77 2 term term NN cord-309161-ceahghs1 77 3 manageable manageable JJ cord-309161-ceahghs1 77 4 stressors stressor NNS cord-309161-ceahghs1 77 5 , , , cord-309161-ceahghs1 77 6 such such JJ cord-309161-ceahghs1 77 7 as as IN cord-309161-ceahghs1 77 8 physical physical JJ cord-309161-ceahghs1 77 9 or or CC cord-309161-ceahghs1 77 10 cognitive cognitive JJ cord-309161-ceahghs1 77 11 challenge challenge NN cord-309161-ceahghs1 77 12 that that WDT cord-309161-ceahghs1 77 13 can can MD cord-309161-ceahghs1 77 14 promote promote VB cord-309161-ceahghs1 77 15 growth growth NN cord-309161-ceahghs1 77 16 , , , cord-309161-ceahghs1 77 17 learning learning NN cord-309161-ceahghs1 77 18 and and CC cord-309161-ceahghs1 77 19 development development NN cord-309161-ceahghs1 77 20 can can MD cord-309161-ceahghs1 77 21 lead lead VB cord-309161-ceahghs1 77 22 to to IN cord-309161-ceahghs1 77 23 protective protective JJ cord-309161-ceahghs1 77 24 responses response NNS cord-309161-ceahghs1 77 25 . . . cord-309161-ceahghs1 78 1 An an DT cord-309161-ceahghs1 78 2 example example NN cord-309161-ceahghs1 78 3 of of IN cord-309161-ceahghs1 78 4 this this DT cord-309161-ceahghs1 78 5 is be VBZ cord-309161-ceahghs1 78 6 found find VBN cord-309161-ceahghs1 78 7 in in IN cord-309161-ceahghs1 78 8 studies study NNS cord-309161-ceahghs1 78 9 of of IN cord-309161-ceahghs1 78 10 the the DT cord-309161-ceahghs1 78 11 Experience Experience NNP cord-309161-ceahghs1 78 12 Corps Corps NNP cord-309161-ceahghs1 78 13 . . . cord-309161-ceahghs1 79 1 Exposing expose VBG cord-309161-ceahghs1 79 2 elderly elderly JJ cord-309161-ceahghs1 79 3 retired retire VBN cord-309161-ceahghs1 79 4 people people NNS cord-309161-ceahghs1 79 5 who who WP cord-309161-ceahghs1 79 6 are be VBP cord-309161-ceahghs1 79 7 often often RB cord-309161-ceahghs1 79 8 isolated isolate VBN cord-309161-ceahghs1 79 9 to to IN cord-309161-ceahghs1 79 10 a a DT cord-309161-ceahghs1 79 11 job job NN cord-309161-ceahghs1 79 12 mentoring mentor VBG cord-309161-ceahghs1 79 13 at at IN cord-309161-ceahghs1 79 14 - - HYPH cord-309161-ceahghs1 79 15 risk risk NN cord-309161-ceahghs1 79 16 youth youth NN cord-309161-ceahghs1 79 17 in in IN cord-309161-ceahghs1 79 18 schools school NNS cord-309161-ceahghs1 79 19 is be VBZ cord-309161-ceahghs1 79 20 often often RB cord-309161-ceahghs1 79 21 viewed view VBN cord-309161-ceahghs1 79 22 as as RB cord-309161-ceahghs1 79 23 stressful stressful JJ cord-309161-ceahghs1 79 24 but but CC cord-309161-ceahghs1 79 25 leads lead VBZ cord-309161-ceahghs1 79 26 to to IN cord-309161-ceahghs1 79 27 feeling feel VBG cord-309161-ceahghs1 79 28 more more JJR cord-309161-ceahghs1 79 29 purpose purpose NN cord-309161-ceahghs1 79 30 in in IN cord-309161-ceahghs1 79 31 life life NN cord-309161-ceahghs1 79 32 . . . cord-309161-ceahghs1 80 1 In in IN cord-309161-ceahghs1 80 2 men man NNS cord-309161-ceahghs1 80 3 , , , cord-309161-ceahghs1 80 4 it -PRON- PRP cord-309161-ceahghs1 80 5 has have VBZ cord-309161-ceahghs1 80 6 been be VBN cord-309161-ceahghs1 80 7 linked link VBN cord-309161-ceahghs1 80 8 to to IN cord-309161-ceahghs1 80 9 better well JJR cord-309161-ceahghs1 80 10 health health NN cord-309161-ceahghs1 80 11 and and CC cord-309161-ceahghs1 80 12 increases increase NNS cord-309161-ceahghs1 80 13 in in IN cord-309161-ceahghs1 80 14 hippocampal hippocampal JJ cord-309161-ceahghs1 80 15 volume volume NN cord-309161-ceahghs1 80 16 Gruenewald Gruenewald NNP cord-309161-ceahghs1 80 17 et et NNP cord-309161-ceahghs1 80 18 al al NNP cord-309161-ceahghs1 80 19 . . NNP cord-309161-ceahghs1 80 20 , , , cord-309161-ceahghs1 80 21 2015 2015 CD cord-309161-ceahghs1 80 22 ; ; : cord-309161-ceahghs1 80 23 Varma Varma NNP cord-309161-ceahghs1 80 24 et et NNP cord-309161-ceahghs1 80 25 al al NNP cord-309161-ceahghs1 80 26 . . NNP cord-309161-ceahghs1 80 27 , , , cord-309161-ceahghs1 80 28 2015 2015 CD cord-309161-ceahghs1 80 29 ) ) -RRB- cord-309161-ceahghs1 80 30 . . . cord-309161-ceahghs1 81 1 In in IN cord-309161-ceahghs1 81 2 the the DT cord-309161-ceahghs1 81 3 case case NN cord-309161-ceahghs1 81 4 of of IN cord-309161-ceahghs1 81 5 coping cope VBG cord-309161-ceahghs1 81 6 with with IN cord-309161-ceahghs1 81 7 chronic chronic JJ cord-309161-ceahghs1 81 8 stressors stressor NNS cord-309161-ceahghs1 81 9 , , , cord-309161-ceahghs1 81 10 most most JJS cord-309161-ceahghs1 81 11 people people NNS cord-309161-ceahghs1 81 12 ( ( -LRB- cord-309161-ceahghs1 81 13 around around IN cord-309161-ceahghs1 81 14 80 80 CD cord-309161-ceahghs1 81 15 % % NN cord-309161-ceahghs1 81 16 ) ) -RRB- cord-309161-ceahghs1 81 17 recover recover VBP cord-309161-ceahghs1 81 18 to to IN cord-309161-ceahghs1 81 19 baseline baseline JJ cord-309161-ceahghs1 81 20 levels level NNS cord-309161-ceahghs1 81 21 of of IN cord-309161-ceahghs1 81 22 well well RB cord-309161-ceahghs1 81 23 being be VBG cord-309161-ceahghs1 81 24 after after IN cord-309161-ceahghs1 81 25 a a DT cord-309161-ceahghs1 81 26 loss loss NN cord-309161-ceahghs1 81 27 or or CC cord-309161-ceahghs1 81 28 disaster disaster NN cord-309161-ceahghs1 82 1 ( ( -LRB- cord-309161-ceahghs1 82 2 Galatzer Galatzer NNP cord-309161-ceahghs1 82 3 - - HYPH cord-309161-ceahghs1 82 4 Levy Levy NNP cord-309161-ceahghs1 82 5 et et NNP cord-309161-ceahghs1 82 6 al al NNP cord-309161-ceahghs1 82 7 . . NNP cord-309161-ceahghs1 82 8 , , , cord-309161-ceahghs1 82 9 2018 2018 CD cord-309161-ceahghs1 82 10 ) ) -RRB- cord-309161-ceahghs1 82 11 . . . cord-309161-ceahghs1 83 1 Resilience resilience NN cord-309161-ceahghs1 83 2 may may MD cord-309161-ceahghs1 83 3 develop develop VB cord-309161-ceahghs1 83 4 over over IN cord-309161-ceahghs1 83 5 time time NN cord-309161-ceahghs1 83 6 , , , cord-309161-ceahghs1 83 7 leading lead VBG cord-309161-ceahghs1 83 8 to to IN cord-309161-ceahghs1 83 9 more more JJR cord-309161-ceahghs1 83 10 mastery mastery NN cord-309161-ceahghs1 83 11 , , , cord-309161-ceahghs1 83 12 purpose purpose NN cord-309161-ceahghs1 83 13 , , , cord-309161-ceahghs1 83 14 faith faith NN cord-309161-ceahghs1 83 15 , , , cord-309161-ceahghs1 83 16 self self NN cord-309161-ceahghs1 83 17 esteem esteem NN cord-309161-ceahghs1 83 18 , , , cord-309161-ceahghs1 83 19 and and CC cord-309161-ceahghs1 83 20 thus thus RB cord-309161-ceahghs1 83 21 more more RBR cord-309161-ceahghs1 83 22 resilient resilient JJ cord-309161-ceahghs1 83 23 responses response NNS cord-309161-ceahghs1 83 24 to to IN cord-309161-ceahghs1 83 25 future future JJ cord-309161-ceahghs1 83 26 stressors stressor NNS cord-309161-ceahghs1 83 27 . . . cord-309161-ceahghs1 84 1 In in IN cord-309161-ceahghs1 84 2 contrast contrast NN cord-309161-ceahghs1 84 3 , , , cord-309161-ceahghs1 84 4 toxic toxic JJ cord-309161-ceahghs1 84 5 exposures exposure NNS cord-309161-ceahghs1 84 6 accumulate accumulate VBP cord-309161-ceahghs1 84 7 over over IN cord-309161-ceahghs1 84 8 a a DT cord-309161-ceahghs1 84 9 lifetime lifetime NN cord-309161-ceahghs1 84 10 , , , cord-309161-ceahghs1 84 11 promoting promote VBG cord-309161-ceahghs1 84 12 " " `` cord-309161-ceahghs1 84 13 stress stress NN cord-309161-ceahghs1 84 14 - - HYPH cord-309161-ceahghs1 84 15 acceleration acceleration NN cord-309161-ceahghs1 84 16 of of IN cord-309161-ceahghs1 84 17 aging age VBG cord-309161-ceahghs1 84 18 " " '' cord-309161-ceahghs1 84 19 processes process NNS cord-309161-ceahghs1 84 20 . . . cord-309161-ceahghs1 85 1 Chronic chronic JJ cord-309161-ceahghs1 85 2 stressors stressor NNS cord-309161-ceahghs1 85 3 for for IN cord-309161-ceahghs1 85 4 decades decade NNS cord-309161-ceahghs1 85 5 , , , cord-309161-ceahghs1 85 6 multiple multiple JJ cord-309161-ceahghs1 85 7 shorter short JJR cord-309161-ceahghs1 85 8 term term NN cord-309161-ceahghs1 85 9 exposures exposure NNS cord-309161-ceahghs1 85 10 over over IN cord-309161-ceahghs1 85 11 years year NNS cord-309161-ceahghs1 85 12 , , , cord-309161-ceahghs1 85 13 and and CC cord-309161-ceahghs1 85 14 stressors stressor NNS cord-309161-ceahghs1 85 15 embedded embed VBN cord-309161-ceahghs1 85 16 early early RB cord-309161-ceahghs1 85 17 in in IN cord-309161-ceahghs1 85 18 life life NN cord-309161-ceahghs1 85 19 , , , cord-309161-ceahghs1 85 20 can can MD cord-309161-ceahghs1 85 21 all all DT cord-309161-ceahghs1 85 22 have have VB cord-309161-ceahghs1 85 23 toxic toxic JJ cord-309161-ceahghs1 85 24 effects effect NNS cord-309161-ceahghs1 85 25 when when WRB cord-309161-ceahghs1 85 26 there there EX cord-309161-ceahghs1 85 27 is be VBZ cord-309161-ceahghs1 85 28 insufficient insufficient JJ cord-309161-ceahghs1 85 29 resources resource NNS cord-309161-ceahghs1 85 30 to to TO cord-309161-ceahghs1 85 31 cope cope VB cord-309161-ceahghs1 85 32 , , , cord-309161-ceahghs1 85 33 and and CC cord-309161-ceahghs1 85 34 nor nor CC cord-309161-ceahghs1 85 35 opportunities opportunity NNS cord-309161-ceahghs1 85 36 to to TO cord-309161-ceahghs1 85 37 fully fully RB cord-309161-ceahghs1 85 38 recover recover VB cord-309161-ceahghs1 85 39 . . . cord-309161-ceahghs1 86 1 Developmental developmental JJ cord-309161-ceahghs1 86 2 factors factor NNS cord-309161-ceahghs1 86 3 are be VBP cord-309161-ceahghs1 86 4 critical critical JJ cord-309161-ceahghs1 86 5 for for IN cord-309161-ceahghs1 86 6 understanding understanding NN cord-309161-ceahghs1 86 7 when when WRB cord-309161-ceahghs1 86 8 stressors stressor NNS cord-309161-ceahghs1 86 9 can can MD cord-309161-ceahghs1 86 10 be be VB cord-309161-ceahghs1 86 11 hormetic hormetic JJ cord-309161-ceahghs1 86 12 vs. vs. FW cord-309161-ceahghs1 86 13 toxic toxic JJ cord-309161-ceahghs1 86 14 . . . cord-309161-ceahghs1 87 1 We -PRON- PRP cord-309161-ceahghs1 87 2 do do VBP cord-309161-ceahghs1 87 3 not not RB cord-309161-ceahghs1 87 4 know know VB cord-309161-ceahghs1 87 5 precise precise JJ cord-309161-ceahghs1 87 6 developmental developmental JJ cord-309161-ceahghs1 87 7 trajectories trajectory NNS cord-309161-ceahghs1 87 8 for for IN cord-309161-ceahghs1 87 9 differential differential JJ cord-309161-ceahghs1 87 10 effects effect NNS cord-309161-ceahghs1 87 11 of of IN cord-309161-ceahghs1 87 12 toxic toxic JJ cord-309161-ceahghs1 87 13 stress stress NN cord-309161-ceahghs1 87 14 on on IN cord-309161-ceahghs1 87 15 mental mental JJ cord-309161-ceahghs1 87 16 and and CC cord-309161-ceahghs1 87 17 physical physical JJ cord-309161-ceahghs1 87 18 health health NN cord-309161-ceahghs1 87 19 and and CC cord-309161-ceahghs1 87 20 even even RB cord-309161-ceahghs1 87 21 less less RBR cord-309161-ceahghs1 87 22 is be VBZ cord-309161-ceahghs1 87 23 known know VBN cord-309161-ceahghs1 87 24 about about IN cord-309161-ceahghs1 87 25 hormesis hormesis NN cord-309161-ceahghs1 87 26 across across IN cord-309161-ceahghs1 87 27 the the DT cord-309161-ceahghs1 87 28 human human JJ cord-309161-ceahghs1 87 29 lifespan lifespan NN cord-309161-ceahghs1 87 30 . . . cord-309161-ceahghs1 88 1 With with IN cord-309161-ceahghs1 88 2 aging age VBG cord-309161-ceahghs1 88 3 , , , cord-309161-ceahghs1 88 4 there there EX cord-309161-ceahghs1 88 5 is be VBZ cord-309161-ceahghs1 88 6 a a DT cord-309161-ceahghs1 88 7 decrease decrease NN cord-309161-ceahghs1 88 8 in in IN cord-309161-ceahghs1 88 9 both both CC cord-309161-ceahghs1 88 10 the the DT cord-309161-ceahghs1 88 11 reproductive reproductive JJ cord-309161-ceahghs1 88 12 and and CC cord-309161-ceahghs1 88 13 anabolic anabolic JJ cord-309161-ceahghs1 88 14 hormones hormone NNS cord-309161-ceahghs1 88 15 that that WDT cord-309161-ceahghs1 88 16 are be VBP cord-309161-ceahghs1 88 17 part part NN cord-309161-ceahghs1 88 18 of of IN cord-309161-ceahghs1 88 19 a a DT cord-309161-ceahghs1 88 20 salutary salutary JJ cord-309161-ceahghs1 88 21 acute acute JJ cord-309161-ceahghs1 88 22 stress stress NN cord-309161-ceahghs1 88 23 response response NN cord-309161-ceahghs1 88 24 ( ( -LRB- cord-309161-ceahghs1 88 25 Epel Epel NNP cord-309161-ceahghs1 88 26 et et NNP cord-309161-ceahghs1 88 27 al al NNP cord-309161-ceahghs1 88 28 . . NNP cord-309161-ceahghs1 88 29 , , , cord-309161-ceahghs1 88 30 1998 1998 CD cord-309161-ceahghs1 88 31 ) ) -RRB- cord-309161-ceahghs1 88 32 , , , cord-309161-ceahghs1 88 33 and and CC cord-309161-ceahghs1 88 34 also also RB cord-309161-ceahghs1 88 35 a a DT cord-309161-ceahghs1 88 36 reduction reduction NN cord-309161-ceahghs1 88 37 in in IN cord-309161-ceahghs1 88 38 aspects aspect NNS cord-309161-ceahghs1 88 39 of of IN cord-309161-ceahghs1 88 40 molecular molecular JJ cord-309161-ceahghs1 88 41 hormesis hormesis NN cord-309161-ceahghs1 88 42 , , , cord-309161-ceahghs1 88 43 such such JJ cord-309161-ceahghs1 88 44 as as IN cord-309161-ceahghs1 88 45 a a DT cord-309161-ceahghs1 88 46 lower low JJR cord-309161-ceahghs1 88 47 heat heat NN cord-309161-ceahghs1 88 48 shock shock NN cord-309161-ceahghs1 88 49 response response NN cord-309161-ceahghs1 88 50 to to IN cord-309161-ceahghs1 88 51 stressors stressor NNS cord-309161-ceahghs1 88 52 ( ( -LRB- cord-309161-ceahghs1 88 53 Calabrese Calabrese NNP cord-309161-ceahghs1 88 54 et et NNP cord-309161-ceahghs1 88 55 al al NNP cord-309161-ceahghs1 88 56 . . NNP cord-309161-ceahghs1 88 57 , , , cord-309161-ceahghs1 88 58 2014 2014 CD cord-309161-ceahghs1 88 59 ; ; : cord-309161-ceahghs1 88 60 Epel Epel NNP cord-309161-ceahghs1 88 61 , , , cord-309161-ceahghs1 88 62 2008 2008 CD cord-309161-ceahghs1 88 63 ) ) -RRB- cord-309161-ceahghs1 88 64 . . . cord-309161-ceahghs1 89 1 We -PRON- PRP cord-309161-ceahghs1 89 2 know know VBP cord-309161-ceahghs1 89 3 most most RBS cord-309161-ceahghs1 89 4 about about IN cord-309161-ceahghs1 89 5 the the DT cord-309161-ceahghs1 89 6 developmental developmental JJ cord-309161-ceahghs1 89 7 impact impact NN cord-309161-ceahghs1 89 8 of of IN cord-309161-ceahghs1 89 9 toxic toxic JJ cord-309161-ceahghs1 89 10 stressors stressor NNS cord-309161-ceahghs1 89 11 . . . cord-309161-ceahghs1 90 1 While while IN cord-309161-ceahghs1 90 2 there there EX cord-309161-ceahghs1 90 3 are be VBP cord-309161-ceahghs1 90 4 myriad myriad JJ cord-309161-ceahghs1 90 5 individual individual JJ cord-309161-ceahghs1 90 6 patterns pattern NNS cord-309161-ceahghs1 90 7 of of IN cord-309161-ceahghs1 90 8 exposures exposure NNS cord-309161-ceahghs1 90 9 , , , cord-309161-ceahghs1 90 10 traumatic traumatic JJ cord-309161-ceahghs1 90 11 stress stress NN cord-309161-ceahghs1 90 12 or or CC cord-309161-ceahghs1 90 13 material material NN cord-309161-ceahghs1 90 14 deprivation deprivation NN cord-309161-ceahghs1 90 15 have have VBP cord-309161-ceahghs1 90 16 larger large JJR cord-309161-ceahghs1 90 17 effects effect NNS cord-309161-ceahghs1 90 18 early early RB cord-309161-ceahghs1 90 19 in in IN cord-309161-ceahghs1 90 20 life life NN cord-309161-ceahghs1 90 21 than than IN cord-309161-ceahghs1 90 22 when when WRB cord-309161-ceahghs1 90 23 they -PRON- PRP cord-309161-ceahghs1 90 24 occur occur VBP cord-309161-ceahghs1 90 25 at at IN cord-309161-ceahghs1 90 26 later later JJ cord-309161-ceahghs1 90 27 periods period NNS cord-309161-ceahghs1 90 28 ; ; : cord-309161-ceahghs1 90 29 Early early JJ cord-309161-ceahghs1 90 30 life life NN cord-309161-ceahghs1 90 31 adversity adversity NN cord-309161-ceahghs1 90 32 is be VBZ cord-309161-ceahghs1 90 33 predictive predictive JJ cord-309161-ceahghs1 90 34 of of IN cord-309161-ceahghs1 90 35 a a DT cord-309161-ceahghs1 90 36 range range NN cord-309161-ceahghs1 90 37 of of IN cord-309161-ceahghs1 90 38 poor poor JJ cord-309161-ceahghs1 90 39 outcomes outcome NNS cord-309161-ceahghs1 90 40 , , , cord-309161-ceahghs1 90 41 including include VBG cord-309161-ceahghs1 90 42 poor poor JJ cord-309161-ceahghs1 90 43 mental mental JJ cord-309161-ceahghs1 90 44 health health NN cord-309161-ceahghs1 90 45 , , , cord-309161-ceahghs1 90 46 health health NN cord-309161-ceahghs1 90 47 behaviors behavior NNS cord-309161-ceahghs1 90 48 , , , cord-309161-ceahghs1 90 49 biomarkers biomarker NNS cord-309161-ceahghs1 90 50 of of IN cord-309161-ceahghs1 90 51 aging age VBG cord-309161-ceahghs1 90 52 , , , cord-309161-ceahghs1 90 53 and and CC cord-309161-ceahghs1 90 54 earlier early JJR cord-309161-ceahghs1 90 55 disease disease NN cord-309161-ceahghs1 90 56 onset onset NN cord-309161-ceahghs1 90 57 ( ( -LRB- cord-309161-ceahghs1 90 58 Deighton Deighton NNP cord-309161-ceahghs1 90 59 et et FW cord-309161-ceahghs1 90 60 al al NNP cord-309161-ceahghs1 90 61 . . NNP cord-309161-ceahghs1 90 62 , , , cord-309161-ceahghs1 90 63 2018 2018 CD cord-309161-ceahghs1 90 64 ; ; . cord-309161-ceahghs1 91 1 Hughes Hughes NNP cord-309161-ceahghs1 91 2 et et NNP cord-309161-ceahghs1 91 3 al al NNP cord-309161-ceahghs1 91 4 . . NNP cord-309161-ceahghs1 91 5 , , , cord-309161-ceahghs1 91 6 2017 2017 CD cord-309161-ceahghs1 91 7 ) ) -RRB- cord-309161-ceahghs1 92 1 although although IN cord-309161-ceahghs1 92 2 plasticity plasticity NN cord-309161-ceahghs1 92 3 is be VBZ cord-309161-ceahghs1 92 4 still still RB cord-309161-ceahghs1 92 5 possible possible JJ cord-309161-ceahghs1 92 6 ( ( -LRB- cord-309161-ceahghs1 92 7 McEwen McEwen NNP cord-309161-ceahghs1 92 8 & & CC cord-309161-ceahghs1 92 9 Morrison Morrison NNP cord-309161-ceahghs1 92 10 , , , cord-309161-ceahghs1 92 11 2013 2013 CD cord-309161-ceahghs1 92 12 ) ) -RRB- cord-309161-ceahghs1 92 13 . . . cord-309161-ceahghs1 93 1 Given give VBN cord-309161-ceahghs1 93 2 the the DT cord-309161-ceahghs1 93 3 sensitive sensitive JJ cord-309161-ceahghs1 93 4 period period NN cord-309161-ceahghs1 94 1 J J NNP cord-309161-ceahghs1 94 2 o o NN cord-309161-ceahghs1 94 3 u u NN cord-309161-ceahghs1 94 4 r r NN cord-309161-ceahghs1 94 5 n n NN cord-309161-ceahghs1 94 6 a a DT cord-309161-ceahghs1 94 7 l l NN cord-309161-ceahghs1 94 8 P p NN cord-309161-ceahghs1 94 9 r r NN cord-309161-ceahghs1 94 10 e e NN cord-309161-ceahghs1 95 1 -p -p : cord-309161-ceahghs1 96 1 r r NNP cord-309161-ceahghs1 96 2 o o NN cord-309161-ceahghs1 96 3 o o NN cord-309161-ceahghs1 96 4 f f NN cord-309161-ceahghs1 96 5 of of IN cord-309161-ceahghs1 96 6 pregnancy pregnancy NN cord-309161-ceahghs1 96 7 , , , cord-309161-ceahghs1 96 8 it -PRON- PRP cord-309161-ceahghs1 96 9 is be VBZ cord-309161-ceahghs1 96 10 not not RB cord-309161-ceahghs1 96 11 surprising surprising JJ cord-309161-ceahghs1 97 1 there there EX cord-309161-ceahghs1 97 2 is be VBZ cord-309161-ceahghs1 97 3 evidence evidence NN cord-309161-ceahghs1 97 4 of of IN cord-309161-ceahghs1 97 5 transgenerational transgenerational JJ cord-309161-ceahghs1 97 6 effects effect NNS cord-309161-ceahghs1 97 7 of of IN cord-309161-ceahghs1 97 8 stress stress NN cord-309161-ceahghs1 97 9 and and CC cord-309161-ceahghs1 97 10 pregnancy pregnancy NN cord-309161-ceahghs1 97 11 complications complication NNS cord-309161-ceahghs1 97 12 on on IN cord-309161-ceahghs1 97 13 systems system NNS cord-309161-ceahghs1 97 14 regulating regulate VBG cord-309161-ceahghs1 97 15 aging age VBG cord-309161-ceahghs1 97 16 like like IN cord-309161-ceahghs1 97 17 telomeres telomere NNS cord-309161-ceahghs1 97 18 and and CC cord-309161-ceahghs1 97 19 epigenetics epigenetic NNS cord-309161-ceahghs1 97 20 ( ( -LRB- cord-309161-ceahghs1 97 21 Epel Epel NNP cord-309161-ceahghs1 97 22 , , , cord-309161-ceahghs1 97 23 2020 2020 CD cord-309161-ceahghs1 97 24 ; ; . cord-309161-ceahghs1 98 1 Girchenko Girchenko NNP cord-309161-ceahghs1 98 2 et et NNP cord-309161-ceahghs1 98 3 al al NNP cord-309161-ceahghs1 98 4 . . NNP cord-309161-ceahghs1 98 5 , , , cord-309161-ceahghs1 98 6 2017 2017 CD cord-309161-ceahghs1 99 1 ; ; : cord-309161-ceahghs1 99 2 Ross Ross NNP cord-309161-ceahghs1 99 3 et et NNP cord-309161-ceahghs1 99 4 al al NNP cord-309161-ceahghs1 99 5 . . NNP cord-309161-ceahghs1 99 6 , , , cord-309161-ceahghs1 99 7 2020 2020 CD cord-309161-ceahghs1 99 8 ) ) -RRB- cord-309161-ceahghs1 99 9 . . . cord-309161-ceahghs1 100 1 A a DT cord-309161-ceahghs1 100 2 careful careful JJ cord-309161-ceahghs1 100 3 meta meta NN cord-309161-ceahghs1 100 4 - - HYPH cord-309161-ceahghs1 100 5 analysis analysis NN cord-309161-ceahghs1 100 6 of of IN cord-309161-ceahghs1 100 7 the the DT cord-309161-ceahghs1 100 8 effects effect NNS cord-309161-ceahghs1 100 9 of of IN cord-309161-ceahghs1 100 10 early early JJ cord-309161-ceahghs1 100 11 adversity adversity NN cord-309161-ceahghs1 100 12 points point NNS cord-309161-ceahghs1 100 13 to to IN cord-309161-ceahghs1 100 14 psychological psychological JJ cord-309161-ceahghs1 100 15 threat threat NN cord-309161-ceahghs1 100 16 , , , cord-309161-ceahghs1 100 17 rather rather RB cord-309161-ceahghs1 100 18 than than IN cord-309161-ceahghs1 100 19 material material JJ cord-309161-ceahghs1 100 20 deprivation deprivation NN cord-309161-ceahghs1 100 21 , , , cord-309161-ceahghs1 100 22 as as IN cord-309161-ceahghs1 100 23 the the DT cord-309161-ceahghs1 100 24 factor factor NN cord-309161-ceahghs1 100 25 underlying underlie VBG cord-309161-ceahghs1 100 26 accelerated accelerate VBN cord-309161-ceahghs1 100 27 biological biological JJ cord-309161-ceahghs1 100 28 aging age VBG cord-309161-ceahghs1 100 29 such such JJ cord-309161-ceahghs1 100 30 as as IN cord-309161-ceahghs1 100 31 early early JJ cord-309161-ceahghs1 100 32 puberty puberty NN cord-309161-ceahghs1 100 33 , , , cord-309161-ceahghs1 100 34 telomere telomere NN cord-309161-ceahghs1 100 35 shortening shortening NN cord-309161-ceahghs1 100 36 , , , cord-309161-ceahghs1 100 37 and and CC cord-309161-ceahghs1 100 38 brain brain NN cord-309161-ceahghs1 100 39 development development NN cord-309161-ceahghs1 100 40 ( ( -LRB- cord-309161-ceahghs1 100 41 Colich Colich NNP cord-309161-ceahghs1 100 42 et et NNP cord-309161-ceahghs1 100 43 al al NNP cord-309161-ceahghs1 100 44 . . NNP cord-309161-ceahghs1 100 45 , , , cord-309161-ceahghs1 100 46 2020 2020 CD cord-309161-ceahghs1 100 47 ) ) -RRB- cord-309161-ceahghs1 100 48 . . . cord-309161-ceahghs1 101 1 For for IN cord-309161-ceahghs1 101 2 trauma trauma NN cord-309161-ceahghs1 101 3 and and CC cord-309161-ceahghs1 101 4 abuse abuse NN cord-309161-ceahghs1 101 5 , , , cord-309161-ceahghs1 101 6 the the DT cord-309161-ceahghs1 101 7 earlier early RBR cord-309161-ceahghs1 101 8 in in IN cord-309161-ceahghs1 101 9 life life NN cord-309161-ceahghs1 101 10 , , , cord-309161-ceahghs1 101 11 prenatal prenatal JJ cord-309161-ceahghs1 101 12 and and CC cord-309161-ceahghs1 101 13 pre pre JJ cord-309161-ceahghs1 101 14 - - JJ cord-309161-ceahghs1 101 15 pubertal pubertal JJ cord-309161-ceahghs1 101 16 , , , cord-309161-ceahghs1 101 17 when when WRB cord-309161-ceahghs1 101 18 the the DT cord-309161-ceahghs1 101 19 brain brain NN cord-309161-ceahghs1 101 20 is be VBZ cord-309161-ceahghs1 101 21 most most RBS cord-309161-ceahghs1 101 22 rapidly rapidly RB cord-309161-ceahghs1 101 23 developing develop VBG cord-309161-ceahghs1 101 24 , , , cord-309161-ceahghs1 101 25 the the DT cord-309161-ceahghs1 101 26 larger large JJR cord-309161-ceahghs1 101 27 the the DT cord-309161-ceahghs1 101 28 imprint imprint NN cord-309161-ceahghs1 101 29 of of IN cord-309161-ceahghs1 101 30 lifelong lifelong JJ cord-309161-ceahghs1 101 31 effects effect NNS cord-309161-ceahghs1 101 32 on on IN cord-309161-ceahghs1 101 33 mental mental JJ cord-309161-ceahghs1 101 34 and and CC cord-309161-ceahghs1 101 35 physical physical JJ cord-309161-ceahghs1 101 36 health health NN cord-309161-ceahghs1 102 1 ( ( -LRB- cord-309161-ceahghs1 102 2 Agorastos Agorastos NNP cord-309161-ceahghs1 102 3 et et NNP cord-309161-ceahghs1 102 4 al al NNP cord-309161-ceahghs1 102 5 . . NNP cord-309161-ceahghs1 102 6 , , , cord-309161-ceahghs1 102 7 2018 2018 CD cord-309161-ceahghs1 102 8 ) ) -RRB- cord-309161-ceahghs1 102 9 . . . cord-309161-ceahghs1 103 1 There there EX cord-309161-ceahghs1 103 2 are be VBP cord-309161-ceahghs1 103 3 many many JJ cord-309161-ceahghs1 103 4 examples example NNS cord-309161-ceahghs1 103 5 of of IN cord-309161-ceahghs1 103 6 early early JJ cord-309161-ceahghs1 103 7 adversity adversity NN cord-309161-ceahghs1 103 8 with with IN cord-309161-ceahghs1 103 9 accelerated accelerated JJ cord-309161-ceahghs1 103 10 biomarkers biomarker NNS cord-309161-ceahghs1 103 11 of of IN cord-309161-ceahghs1 103 12 aging age VBG cord-309161-ceahghs1 103 13 in in IN cord-309161-ceahghs1 103 14 children child NNS cord-309161-ceahghs1 103 15 : : : cord-309161-ceahghs1 104 1 In in IN cord-309161-ceahghs1 104 2 prepubertal prepubertal JJ cord-309161-ceahghs1 104 3 children child NNS cord-309161-ceahghs1 104 4 , , , cord-309161-ceahghs1 104 5 early early JJ cord-309161-ceahghs1 104 6 life life NN cord-309161-ceahghs1 104 7 adversity adversity NN cord-309161-ceahghs1 104 8 leads lead VBZ cord-309161-ceahghs1 104 9 to to IN cord-309161-ceahghs1 104 10 greater great JJR cord-309161-ceahghs1 104 11 inflammatory inflammatory JJ cord-309161-ceahghs1 104 12 acute acute JJ cord-309161-ceahghs1 104 13 stress stress NN cord-309161-ceahghs1 104 14 response response NN cord-309161-ceahghs1 104 15 , , , cord-309161-ceahghs1 104 16 and and CC cord-309161-ceahghs1 104 17 basal basal NN cord-309161-ceahghs1 104 18 inflammation inflammation NN cord-309161-ceahghs1 104 19 several several JJ cord-309161-ceahghs1 104 20 years year NNS cord-309161-ceahghs1 104 21 later later RB cord-309161-ceahghs1 105 1 ( ( -LRB- cord-309161-ceahghs1 105 2 Slopen Slopen NNP cord-309161-ceahghs1 105 3 et et NNP cord-309161-ceahghs1 105 4 al al NNP cord-309161-ceahghs1 105 5 . . NNP cord-309161-ceahghs1 105 6 , , , cord-309161-ceahghs1 105 7 2014 2014 CD cord-309161-ceahghs1 105 8 ) ) -RRB- cord-309161-ceahghs1 105 9 . . . cord-309161-ceahghs1 106 1 In in IN cord-309161-ceahghs1 106 2 prepubescent prepubescent JJ cord-309161-ceahghs1 106 3 youth youth NN cord-309161-ceahghs1 106 4 , , , cord-309161-ceahghs1 106 5 exposure exposure NN cord-309161-ceahghs1 106 6 to to IN cord-309161-ceahghs1 106 7 violence violence NN cord-309161-ceahghs1 106 8 is be VBZ cord-309161-ceahghs1 106 9 associated associate VBN cord-309161-ceahghs1 106 10 prospectively prospectively RB cord-309161-ceahghs1 106 11 with with IN cord-309161-ceahghs1 106 12 telomere telomere NN cord-309161-ceahghs1 106 13 shortening shortening NN cord-309161-ceahghs1 106 14 ( ( -LRB- cord-309161-ceahghs1 106 15 Shalev Shalev NNP cord-309161-ceahghs1 106 16 et et NNP cord-309161-ceahghs1 106 17 al al NNP cord-309161-ceahghs1 106 18 . . NNP cord-309161-ceahghs1 106 19 , , , cord-309161-ceahghs1 106 20 2013 2013 CD cord-309161-ceahghs1 106 21 ) ) -RRB- cord-309161-ceahghs1 106 22 , , , cord-309161-ceahghs1 106 23 and and CC cord-309161-ceahghs1 106 24 telomere telomere NN cord-309161-ceahghs1 106 25 shortness shortness NN cord-309161-ceahghs1 106 26 in in IN cord-309161-ceahghs1 106 27 early early JJ cord-309161-ceahghs1 106 28 childhood childhood NN cord-309161-ceahghs1 106 29 predicts predict VBZ cord-309161-ceahghs1 106 30 carotid carotid JJ cord-309161-ceahghs1 106 31 artery artery NN cord-309161-ceahghs1 106 32 thickness thickness NN cord-309161-ceahghs1 106 33 several several JJ cord-309161-ceahghs1 106 34 years year NNS cord-309161-ceahghs1 106 35 later later RB cord-309161-ceahghs1 106 36 , , , cord-309161-ceahghs1 106 37 and and CC cord-309161-ceahghs1 106 38 during during IN cord-309161-ceahghs1 106 39 puberty puberty NN cord-309161-ceahghs1 106 40 ( ( -LRB- cord-309161-ceahghs1 106 41 Barraclough Barraclough NNP cord-309161-ceahghs1 106 42 et et NNP cord-309161-ceahghs1 106 43 al al NNP cord-309161-ceahghs1 106 44 . . NNP cord-309161-ceahghs1 106 45 , , , cord-309161-ceahghs1 106 46 2019 2019 CD cord-309161-ceahghs1 106 47 ; ; : cord-309161-ceahghs1 106 48 Skilton Skilton NNP cord-309161-ceahghs1 106 49 et et NNP cord-309161-ceahghs1 106 50 al al NNP cord-309161-ceahghs1 106 51 . . NNP cord-309161-ceahghs1 106 52 , , , cord-309161-ceahghs1 106 53 2016 2016 CD cord-309161-ceahghs1 106 54 ) ) -RRB- cord-309161-ceahghs1 106 55 . . . cord-309161-ceahghs1 107 1 Early early JJ cord-309161-ceahghs1 107 2 adversity adversity NN cord-309161-ceahghs1 107 3 may may MD cord-309161-ceahghs1 107 4 accelerate accelerate VB cord-309161-ceahghs1 107 5 aging age VBG cord-309161-ceahghs1 107 6 in in IN cord-309161-ceahghs1 107 7 part part NN cord-309161-ceahghs1 107 8 through through IN cord-309161-ceahghs1 107 9 inducing induce VBG cord-309161-ceahghs1 107 10 early early JJ cord-309161-ceahghs1 107 11 puberty puberty NN cord-309161-ceahghs1 107 12 which which WDT cord-309161-ceahghs1 107 13 in in IN cord-309161-ceahghs1 107 14 turn turn NN cord-309161-ceahghs1 107 15 is be VBZ cord-309161-ceahghs1 107 16 linked link VBN cord-309161-ceahghs1 107 17 to to IN cord-309161-ceahghs1 107 18 earlier early JJR cord-309161-ceahghs1 107 19 onset onset NN cord-309161-ceahghs1 107 20 of of IN cord-309161-ceahghs1 107 21 metabolic metabolic JJ cord-309161-ceahghs1 107 22 disease disease NN cord-309161-ceahghs1 107 23 ( ( -LRB- cord-309161-ceahghs1 107 24 Gur Gur NNP cord-309161-ceahghs1 107 25 et et FW cord-309161-ceahghs1 107 26 al al NNP cord-309161-ceahghs1 107 27 . . NNP cord-309161-ceahghs1 107 28 , , , cord-309161-ceahghs1 107 29 2019 2019 CD cord-309161-ceahghs1 107 30 ; ; : cord-309161-ceahghs1 107 31 Sun Sun NNP cord-309161-ceahghs1 107 32 et et NNP cord-309161-ceahghs1 107 33 al al NNP cord-309161-ceahghs1 107 34 . . NNP cord-309161-ceahghs1 107 35 , , , cord-309161-ceahghs1 107 36 2017 2017 CD cord-309161-ceahghs1 107 37 ) ) -RRB- cord-309161-ceahghs1 107 38 . . . cord-309161-ceahghs1 108 1 Early early JJ cord-309161-ceahghs1 108 2 adversity adversity NN cord-309161-ceahghs1 108 3 may may MD cord-309161-ceahghs1 108 4 also also RB cord-309161-ceahghs1 108 5 initiate initiate VB cord-309161-ceahghs1 108 6 a a DT cord-309161-ceahghs1 108 7 trajectory trajectory NN cord-309161-ceahghs1 108 8 of of IN cord-309161-ceahghs1 108 9 early early JJ cord-309161-ceahghs1 108 10 aging age VBG cord-309161-ceahghs1 108 11 through through IN cord-309161-ceahghs1 108 12 lower low JJR cord-309161-ceahghs1 108 13 reserve reserve NN cord-309161-ceahghs1 108 14 capacity capacity NN cord-309161-ceahghs1 108 15 such such JJ cord-309161-ceahghs1 108 16 as as IN cord-309161-ceahghs1 108 17 low low JJ cord-309161-ceahghs1 108 18 optimism optimism NN cord-309161-ceahghs1 108 19 and and CC cord-309161-ceahghs1 108 20 higher high JJR cord-309161-ceahghs1 108 21 stressful stressful JJ cord-309161-ceahghs1 108 22 events event NNS cord-309161-ceahghs1 108 23 in in IN cord-309161-ceahghs1 108 24 adulthood adulthood NN cord-309161-ceahghs1 109 1 ( ( -LRB- cord-309161-ceahghs1 109 2 Surachman Surachman NNP cord-309161-ceahghs1 109 3 et et FW cord-309161-ceahghs1 109 4 al al NNP cord-309161-ceahghs1 109 5 . . NNP cord-309161-ceahghs1 109 6 , , , cord-309161-ceahghs1 109 7 2019 2019 CD cord-309161-ceahghs1 109 8 ) ) -RRB- cord-309161-ceahghs1 109 9 . . . cord-309161-ceahghs1 110 1 Early early JJ cord-309161-ceahghs1 110 2 adversity adversity NN cord-309161-ceahghs1 110 3 also also RB cord-309161-ceahghs1 110 4 predicts predict VBZ cord-309161-ceahghs1 110 5 poor poor JJ cord-309161-ceahghs1 110 6 health health NN cord-309161-ceahghs1 110 7 behaviors behavior NNS cord-309161-ceahghs1 110 8 such such JJ cord-309161-ceahghs1 110 9 as as IN cord-309161-ceahghs1 110 10 sedentariness sedentariness NNP cord-309161-ceahghs1 110 11 , , , cord-309161-ceahghs1 110 12 smoking smoking NN cord-309161-ceahghs1 110 13 and and CC cord-309161-ceahghs1 110 14 substance substance NN cord-309161-ceahghs1 110 15 use use NN cord-309161-ceahghs1 110 16 in in IN cord-309161-ceahghs1 110 17 youth youth NN cord-309161-ceahghs1 110 18 ( ( -LRB- cord-309161-ceahghs1 110 19 Wiehn Wiehn NNP cord-309161-ceahghs1 110 20 et et NNP cord-309161-ceahghs1 110 21 al al NNP cord-309161-ceahghs1 110 22 . . NNP cord-309161-ceahghs1 110 23 , , , cord-309161-ceahghs1 110 24 2018 2018 CD cord-309161-ceahghs1 110 25 ) ) -RRB- cord-309161-ceahghs1 110 26 and and CC cord-309161-ceahghs1 110 27 these these DT cord-309161-ceahghs1 110 28 habits habit NNS cord-309161-ceahghs1 110 29 appear appear VBP cord-309161-ceahghs1 110 30 to to TO cord-309161-ceahghs1 110 31 persist persist VB cord-309161-ceahghs1 110 32 long long RB cord-309161-ceahghs1 110 33 into into IN cord-309161-ceahghs1 110 34 adulthood adulthood NN cord-309161-ceahghs1 110 35 . . . cord-309161-ceahghs1 111 1 The the DT cord-309161-ceahghs1 111 2 pillars pillar NNS cord-309161-ceahghs1 111 3 of of IN cord-309161-ceahghs1 111 4 mammalian mammalian JJ cord-309161-ceahghs1 111 5 aging aging NN cord-309161-ceahghs1 111 6 , , , cord-309161-ceahghs1 111 7 represent represent VBP cord-309161-ceahghs1 111 8 fundamental fundamental JJ cord-309161-ceahghs1 111 9 and and CC cord-309161-ceahghs1 111 10 related related JJ cord-309161-ceahghs1 111 11 pathways pathway NNS cord-309161-ceahghs1 111 12 such such JJ cord-309161-ceahghs1 111 13 as as IN cord-309161-ceahghs1 111 14 genomic genomic JJ cord-309161-ceahghs1 111 15 instability instability NN cord-309161-ceahghs1 111 16 , , , cord-309161-ceahghs1 111 17 telomere telomere NN cord-309161-ceahghs1 111 18 attrition attrition NN cord-309161-ceahghs1 111 19 , , , cord-309161-ceahghs1 111 20 epigenetic epigenetic JJ cord-309161-ceahghs1 111 21 alterations alteration NNS cord-309161-ceahghs1 111 22 , , , cord-309161-ceahghs1 111 23 loss loss NN cord-309161-ceahghs1 111 24 of of IN cord-309161-ceahghs1 111 25 proteostasis proteostasis NN cord-309161-ceahghs1 111 26 , , , cord-309161-ceahghs1 111 27 metabolic metabolic JJ cord-309161-ceahghs1 111 28 pathways pathway NNS cord-309161-ceahghs1 111 29 such such JJ cord-309161-ceahghs1 111 30 as as IN cord-309161-ceahghs1 111 31 deregulated deregulate VBN cord-309161-ceahghs1 111 32 nutrient nutrient NN cord-309161-ceahghs1 111 33 sensing sensing NN cord-309161-ceahghs1 111 34 , , , cord-309161-ceahghs1 111 35 mitochondrial mitochondrial NN cord-309161-ceahghs1 111 36 J J NNP cord-309161-ceahghs1 111 37 o o NN cord-309161-ceahghs1 111 38 u u NN cord-309161-ceahghs1 111 39 r r NN cord-309161-ceahghs1 111 40 n n NN cord-309161-ceahghs1 111 41 a a DT cord-309161-ceahghs1 111 42 l l NN cord-309161-ceahghs1 111 43 P p NN cord-309161-ceahghs1 111 44 r r NN cord-309161-ceahghs1 111 45 e e NN cord-309161-ceahghs1 111 46 -p -p NN cord-309161-ceahghs1 111 47 r r NN cord-309161-ceahghs1 111 48 o o NN cord-309161-ceahghs1 112 1 o o UH cord-309161-ceahghs1 112 2 f f NNP cord-309161-ceahghs1 112 3 dysfunction dysfunction NN cord-309161-ceahghs1 112 4 , , , cord-309161-ceahghs1 112 5 cellular cellular JJ cord-309161-ceahghs1 112 6 senescence senescence NN cord-309161-ceahghs1 112 7 , , , cord-309161-ceahghs1 112 8 stem stem NN cord-309161-ceahghs1 112 9 cell cell NN cord-309161-ceahghs1 112 10 exhaustion exhaustion NN cord-309161-ceahghs1 112 11 , , , cord-309161-ceahghs1 112 12 and and CC cord-309161-ceahghs1 112 13 altered alter VBD cord-309161-ceahghs1 112 14 intercellular intercellular JJ cord-309161-ceahghs1 112 15 communication communication NN cord-309161-ceahghs1 112 16 , , , cord-309161-ceahghs1 112 17 macromolecular macromolecular JJ cord-309161-ceahghs1 112 18 damage damage NN cord-309161-ceahghs1 112 19 , , , cord-309161-ceahghs1 112 20 chronic chronic JJ cord-309161-ceahghs1 112 21 low low JJ cord-309161-ceahghs1 112 22 - - HYPH cord-309161-ceahghs1 112 23 grade grade NN cord-309161-ceahghs1 112 24 inflammation inflammation NN cord-309161-ceahghs1 112 25 , , , cord-309161-ceahghs1 112 26 and and CC cord-309161-ceahghs1 112 27 adaptation adaptation NN cord-309161-ceahghs1 112 28 to to TO cord-309161-ceahghs1 112 29 stress stress NN cord-309161-ceahghs1 113 1 ( ( -LRB- cord-309161-ceahghs1 113 2 Kennedy Kennedy NNP cord-309161-ceahghs1 113 3 et et NNP cord-309161-ceahghs1 113 4 al al NNP cord-309161-ceahghs1 113 5 . . NNP cord-309161-ceahghs1 113 6 , , , cord-309161-ceahghs1 113 7 2014 2014 CD cord-309161-ceahghs1 113 8 ; ; : cord-309161-ceahghs1 113 9 López López NNP cord-309161-ceahghs1 113 10 - - HYPH cord-309161-ceahghs1 113 11 Otín Otín NNP cord-309161-ceahghs1 113 12 et et NNP cord-309161-ceahghs1 113 13 al al NNP cord-309161-ceahghs1 113 14 . . NNP cord-309161-ceahghs1 113 15 , , , cord-309161-ceahghs1 113 16 2013 2013 CD cord-309161-ceahghs1 113 17 ) ) -RRB- cord-309161-ceahghs1 113 18 . . . cord-309161-ceahghs1 114 1 Other other JJ cord-309161-ceahghs1 114 2 hallmarks hallmark NNS cord-309161-ceahghs1 114 3 of of IN cord-309161-ceahghs1 114 4 cellular cellular JJ cord-309161-ceahghs1 114 5 aging aging NN cord-309161-ceahghs1 114 6 are be VBP cord-309161-ceahghs1 114 7 being be VBG cord-309161-ceahghs1 114 8 identified identify VBN cord-309161-ceahghs1 114 9 in in IN cord-309161-ceahghs1 114 10 the the DT cord-309161-ceahghs1 114 11 brain brain NN cord-309161-ceahghs1 114 12 ( ( -LRB- cord-309161-ceahghs1 114 13 Mattson Mattson NNP cord-309161-ceahghs1 114 14 & & CC cord-309161-ceahghs1 114 15 Arumugam Arumugam NNP cord-309161-ceahghs1 114 16 , , , cord-309161-ceahghs1 114 17 2018 2018 CD cord-309161-ceahghs1 114 18 ) ) -RRB- cord-309161-ceahghs1 114 19 . . . cord-309161-ceahghs1 115 1 Molecular molecular JJ cord-309161-ceahghs1 115 2 pathways pathway NNS cord-309161-ceahghs1 115 3 are be VBP cord-309161-ceahghs1 115 4 often often RB cord-309161-ceahghs1 115 5 not not RB cord-309161-ceahghs1 115 6 closely closely RB cord-309161-ceahghs1 115 7 related related JJ cord-309161-ceahghs1 115 8 to to IN cord-309161-ceahghs1 115 9 each each DT cord-309161-ceahghs1 115 10 other other JJ cord-309161-ceahghs1 115 11 , , , cord-309161-ceahghs1 115 12 pointing point VBG cord-309161-ceahghs1 115 13 to to IN cord-309161-ceahghs1 115 14 the the DT cord-309161-ceahghs1 115 15 use use NN cord-309161-ceahghs1 115 16 of of IN cord-309161-ceahghs1 115 17 algorithms algorithm NNS cord-309161-ceahghs1 115 18 , , , cord-309161-ceahghs1 115 19 for for IN cord-309161-ceahghs1 115 20 better well JJR cord-309161-ceahghs1 115 21 prediction prediction NN cord-309161-ceahghs1 115 22 of of IN cord-309161-ceahghs1 115 23 outcomes outcome NNS cord-309161-ceahghs1 115 24 , , , cord-309161-ceahghs1 115 25 described describe VBN cord-309161-ceahghs1 115 26 below below RB cord-309161-ceahghs1 115 27 . . . cord-309161-ceahghs1 116 1 Several several JJ cord-309161-ceahghs1 116 2 of of IN cord-309161-ceahghs1 116 3 these these DT cord-309161-ceahghs1 116 4 basic basic JJ cord-309161-ceahghs1 116 5 mechanisms mechanism NNS cord-309161-ceahghs1 116 6 in in IN cord-309161-ceahghs1 116 7 immune immune JJ cord-309161-ceahghs1 116 8 cells cell NNS cord-309161-ceahghs1 116 9 have have VBP cord-309161-ceahghs1 116 10 been be VBN cord-309161-ceahghs1 116 11 associated associate VBN cord-309161-ceahghs1 116 12 with with IN cord-309161-ceahghs1 116 13 aspects aspect NNS cord-309161-ceahghs1 116 14 of of IN cord-309161-ceahghs1 116 15 social social JJ cord-309161-ceahghs1 116 16 stress stress NN cord-309161-ceahghs1 116 17 , , , cord-309161-ceahghs1 116 18 including include VBG cord-309161-ceahghs1 116 19 systemic systemic JJ cord-309161-ceahghs1 116 20 inflammation inflammation NN cord-309161-ceahghs1 116 21 and and CC cord-309161-ceahghs1 116 22 shorter short JJR cord-309161-ceahghs1 116 23 telomeres telomere NNS cord-309161-ceahghs1 117 1 ( ( -LRB- cord-309161-ceahghs1 117 2 Epel Epel NNP cord-309161-ceahghs1 117 3 et et NNP cord-309161-ceahghs1 117 4 al al NNP cord-309161-ceahghs1 117 5 . . NNP cord-309161-ceahghs1 117 6 , , , cord-309161-ceahghs1 117 7 2004 2004 CD cord-309161-ceahghs1 118 1 ; ; : cord-309161-ceahghs1 118 2 Kiecolt Kiecolt NNP cord-309161-ceahghs1 118 3 - - HYPH cord-309161-ceahghs1 118 4 Glaser Glaser NNP cord-309161-ceahghs1 118 5 et et NNP cord-309161-ceahghs1 118 6 al al NNP cord-309161-ceahghs1 118 7 . . NNP cord-309161-ceahghs1 118 8 , , , cord-309161-ceahghs1 118 9 2011 2011 CD cord-309161-ceahghs1 118 10 ; ; : cord-309161-ceahghs1 118 11 Miller Miller NNP cord-309161-ceahghs1 118 12 et et NNP cord-309161-ceahghs1 118 13 al al NNP cord-309161-ceahghs1 118 14 . . NNP cord-309161-ceahghs1 118 15 , , , cord-309161-ceahghs1 118 16 2008 2008 CD cord-309161-ceahghs1 118 17 ) ) -RRB- cord-309161-ceahghs1 119 1 poor poor JJ cord-309161-ceahghs1 119 2 mitochondrial mitochondrial NN cord-309161-ceahghs1 119 3 function function NN cord-309161-ceahghs1 120 1 ( ( -LRB- cord-309161-ceahghs1 120 2 Picard Picard NNP cord-309161-ceahghs1 120 3 et et NNP cord-309161-ceahghs1 120 4 al al NNP cord-309161-ceahghs1 120 5 . . NNP cord-309161-ceahghs1 120 6 , , , cord-309161-ceahghs1 120 7 2018 2018 CD cord-309161-ceahghs1 120 8 ) ) -RRB- cord-309161-ceahghs1 120 9 , , , cord-309161-ceahghs1 120 10 and and CC cord-309161-ceahghs1 120 11 accelerated accelerate VBN cord-309161-ceahghs1 120 12 epigenetic epigenetic JJ cord-309161-ceahghs1 120 13 aging aging NN cord-309161-ceahghs1 120 14 ( ( -LRB- cord-309161-ceahghs1 120 15 Park Park NNP cord-309161-ceahghs1 120 16 et et FW cord-309161-ceahghs1 120 17 al al NNP cord-309161-ceahghs1 120 18 . . NNP cord-309161-ceahghs1 120 19 , , , cord-309161-ceahghs1 120 20 2019 2019 CD cord-309161-ceahghs1 120 21 ; ; : cord-309161-ceahghs1 120 22 Wolf Wolf NNP cord-309161-ceahghs1 120 23 et et NNP cord-309161-ceahghs1 120 24 al al NNP cord-309161-ceahghs1 120 25 . . NNP cord-309161-ceahghs1 120 26 , , , cord-309161-ceahghs1 120 27 2018 2018 CD cord-309161-ceahghs1 120 28 ) ) -RRB- cord-309161-ceahghs1 120 29 . . . cord-309161-ceahghs1 121 1 These these DT cord-309161-ceahghs1 121 2 associations association NNS cord-309161-ceahghs1 121 3 with with IN cord-309161-ceahghs1 121 4 lifespan lifespan NN cord-309161-ceahghs1 121 5 stress stress NN cord-309161-ceahghs1 121 6 demonstrate demonstrate VBP cord-309161-ceahghs1 121 7 there there EX cord-309161-ceahghs1 121 8 is be VBZ cord-309161-ceahghs1 121 9 no no DT cord-309161-ceahghs1 121 10 closed closed JJ cord-309161-ceahghs1 121 11 system system NN cord-309161-ceahghs1 121 12 of of IN cord-309161-ceahghs1 121 13 intrinsic intrinsic JJ cord-309161-ceahghs1 121 14 aging aging NN cord-309161-ceahghs1 121 15 , , , cord-309161-ceahghs1 121 16 and and CC cord-309161-ceahghs1 121 17 even even RB cord-309161-ceahghs1 121 18 at at IN cord-309161-ceahghs1 121 19 these these DT cord-309161-ceahghs1 121 20 most most RBS cord-309161-ceahghs1 121 21 molecular molecular JJ cord-309161-ceahghs1 121 22 levels level NNS cord-309161-ceahghs1 121 23 our -PRON- PRP$ cord-309161-ceahghs1 121 24 aging age VBG cord-309161-ceahghs1 121 25 rate rate NN cord-309161-ceahghs1 121 26 is be VBZ cord-309161-ceahghs1 121 27 influenced influence VBN cord-309161-ceahghs1 121 28 by by IN cord-309161-ceahghs1 121 29 our -PRON- PRP$ cord-309161-ceahghs1 121 30 life life NN cord-309161-ceahghs1 121 31 exposures exposure NNS cord-309161-ceahghs1 121 32 . . . cord-309161-ceahghs1 122 1 We -PRON- PRP cord-309161-ceahghs1 122 2 can can MD cord-309161-ceahghs1 122 3 not not RB cord-309161-ceahghs1 122 4 rule rule VB cord-309161-ceahghs1 122 5 out out RP cord-309161-ceahghs1 122 6 the the DT cord-309161-ceahghs1 122 7 possibility possibility NN cord-309161-ceahghs1 122 8 that that IN cord-309161-ceahghs1 122 9 some some DT cord-309161-ceahghs1 122 10 of of IN cord-309161-ceahghs1 122 11 these these DT cord-309161-ceahghs1 122 12 observations observation NNS cord-309161-ceahghs1 122 13 are be VBP cord-309161-ceahghs1 122 14 from from IN cord-309161-ceahghs1 122 15 transgenerational transgenerational JJ cord-309161-ceahghs1 122 16 effects effect NNS cord-309161-ceahghs1 122 17 . . . cord-309161-ceahghs1 123 1 A a DT cord-309161-ceahghs1 123 2 new new JJ cord-309161-ceahghs1 123 3 practical practical JJ cord-309161-ceahghs1 123 4 approach approach NN cord-309161-ceahghs1 123 5 already already RB cord-309161-ceahghs1 123 6 used use VBN cord-309161-ceahghs1 123 7 in in IN cord-309161-ceahghs1 123 8 humans human NNS cord-309161-ceahghs1 123 9 is be VBZ cord-309161-ceahghs1 123 10 to to TO cord-309161-ceahghs1 123 11 measure measure VB cord-309161-ceahghs1 123 12 a a DT cord-309161-ceahghs1 123 13 panel panel NN cord-309161-ceahghs1 123 14 of of IN cord-309161-ceahghs1 123 15 biomarkers biomarker NNS cord-309161-ceahghs1 123 16 of of IN cord-309161-ceahghs1 123 17 aging age VBG cord-309161-ceahghs1 123 18 that that WDT cord-309161-ceahghs1 123 19 reflect reflect VBP cord-309161-ceahghs1 123 20 cumulative cumulative JJ cord-309161-ceahghs1 123 21 damage damage NN cord-309161-ceahghs1 123 22 across across IN cord-309161-ceahghs1 123 23 regulatory regulatory JJ cord-309161-ceahghs1 123 24 systems system NNS cord-309161-ceahghs1 123 25 ( ( -LRB- cord-309161-ceahghs1 123 26 e.g. e.g. RB cord-309161-ceahghs1 123 27 , , , cord-309161-ceahghs1 123 28 metabolic metabolic JJ cord-309161-ceahghs1 123 29 , , , cord-309161-ceahghs1 123 30 immune immune JJ cord-309161-ceahghs1 123 31 , , , cord-309161-ceahghs1 123 32 stress stress NN cord-309161-ceahghs1 123 33 related relate VBN cord-309161-ceahghs1 123 34 ) ) -RRB- cord-309161-ceahghs1 123 35 , , , cord-309161-ceahghs1 123 36 and and CC cord-309161-ceahghs1 123 37 reducing reduce VBG cord-309161-ceahghs1 123 38 this this DT cord-309161-ceahghs1 123 39 a a DT cord-309161-ceahghs1 123 40 composite composite JJ cord-309161-ceahghs1 123 41 measure measure NN cord-309161-ceahghs1 123 42 . . . cord-309161-ceahghs1 124 1 The the DT cord-309161-ceahghs1 124 2 first first JJ cord-309161-ceahghs1 124 3 of of IN cord-309161-ceahghs1 124 4 these these DT cord-309161-ceahghs1 124 5 measures measure NNS cord-309161-ceahghs1 124 6 was be VBD cord-309161-ceahghs1 124 7 allostatic allostatic JJ cord-309161-ceahghs1 124 8 load load NN cord-309161-ceahghs1 124 9 ( ( -LRB- cord-309161-ceahghs1 124 10 Seeman Seeman NNP cord-309161-ceahghs1 124 11 et et NNP cord-309161-ceahghs1 124 12 al al NNP cord-309161-ceahghs1 124 13 . . NNP cord-309161-ceahghs1 124 14 , , , cord-309161-ceahghs1 124 15 2001 2001 CD cord-309161-ceahghs1 124 16 ) ) -RRB- cord-309161-ceahghs1 124 17 , , , cord-309161-ceahghs1 124 18 and and CC cord-309161-ceahghs1 124 19 there there EX cord-309161-ceahghs1 124 20 are be VBP cord-309161-ceahghs1 124 21 newer new JJR cord-309161-ceahghs1 124 22 algorithm algorithm NN cord-309161-ceahghs1 124 23 measures measure NNS cord-309161-ceahghs1 124 24 like like IN cord-309161-ceahghs1 124 25 ' ' '' cord-309161-ceahghs1 124 26 pace pace NN cord-309161-ceahghs1 124 27 of of IN cord-309161-ceahghs1 124 28 aging aging NN cord-309161-ceahghs1 124 29 ' ' '' cord-309161-ceahghs1 125 1 ( ( -LRB- cord-309161-ceahghs1 125 2 Belsky Belsky NNP cord-309161-ceahghs1 125 3 , , , cord-309161-ceahghs1 125 4 Caspi Caspi NNP cord-309161-ceahghs1 125 5 , , , cord-309161-ceahghs1 125 6 et et NNP cord-309161-ceahghs1 125 7 al al NNP cord-309161-ceahghs1 125 8 . . NNP cord-309161-ceahghs1 125 9 , , , cord-309161-ceahghs1 125 10 2017 2017 CD cord-309161-ceahghs1 125 11 ) ) -RRB- cord-309161-ceahghs1 125 12 , , , cord-309161-ceahghs1 125 13 and and CC cord-309161-ceahghs1 125 14 lack lack NN cord-309161-ceahghs1 125 15 of of IN cord-309161-ceahghs1 125 16 normal normal JJ cord-309161-ceahghs1 125 17 covariation covariation NN cord-309161-ceahghs1 125 18 among among IN cord-309161-ceahghs1 125 19 regulatory regulatory JJ cord-309161-ceahghs1 125 20 systems system NNS cord-309161-ceahghs1 126 1 ( ( -LRB- cord-309161-ceahghs1 126 2 Belsky Belsky NNP cord-309161-ceahghs1 126 3 , , , cord-309161-ceahghs1 126 4 Huffman Huffman NNP cord-309161-ceahghs1 126 5 , , , cord-309161-ceahghs1 126 6 et et NNP cord-309161-ceahghs1 126 7 al al NNP cord-309161-ceahghs1 126 8 . . NNP cord-309161-ceahghs1 126 9 , , , cord-309161-ceahghs1 126 10 2017 2017 CD cord-309161-ceahghs1 126 11 ) ) -RRB- cord-309161-ceahghs1 126 12 . . . cord-309161-ceahghs1 127 1 These these DT cord-309161-ceahghs1 127 2 measures measure NNS cord-309161-ceahghs1 127 3 serve serve VBP cord-309161-ceahghs1 127 4 as as IN cord-309161-ceahghs1 127 5 a a DT cord-309161-ceahghs1 127 6 barometer barometer NN cord-309161-ceahghs1 127 7 of of IN cord-309161-ceahghs1 127 8 biological biological JJ cord-309161-ceahghs1 127 9 aging age VBG cord-309161-ceahghs1 127 10 across across IN cord-309161-ceahghs1 127 11 the the DT cord-309161-ceahghs1 127 12 lifespan lifespan NN cord-309161-ceahghs1 127 13 , , , cord-309161-ceahghs1 127 14 linked link VBN cord-309161-ceahghs1 127 15 to to IN cord-309161-ceahghs1 127 16 early early JJ cord-309161-ceahghs1 127 17 experience experience NN cord-309161-ceahghs1 127 18 , , , cord-309161-ceahghs1 127 19 and and CC cord-309161-ceahghs1 127 20 may may MD cord-309161-ceahghs1 127 21 be be VB cord-309161-ceahghs1 127 22 useful useful JJ cord-309161-ceahghs1 127 23 to to TO cord-309161-ceahghs1 127 24 examine examine VB cord-309161-ceahghs1 127 25 the the DT cord-309161-ceahghs1 127 26 effect effect NN cord-309161-ceahghs1 127 27 of of IN cord-309161-ceahghs1 127 28 interventions intervention NNS cord-309161-ceahghs1 127 29 ( ( -LRB- cord-309161-ceahghs1 127 30 Moffitt Moffitt NNP cord-309161-ceahghs1 127 31 , , , cord-309161-ceahghs1 127 32 this this DT cord-309161-ceahghs1 127 33 issue issue NN cord-309161-ceahghs1 127 34 ) ) -RRB- cord-309161-ceahghs1 127 35 . . . cord-309161-ceahghs1 128 1 So so RB cord-309161-ceahghs1 128 2 far far RB cord-309161-ceahghs1 128 3 , , , cord-309161-ceahghs1 128 4 the the DT cord-309161-ceahghs1 128 5 markers marker NNS cord-309161-ceahghs1 128 6 used use VBN cord-309161-ceahghs1 128 7 have have VBP cord-309161-ceahghs1 128 8 been be VBN cord-309161-ceahghs1 128 9 chosen choose VBN cord-309161-ceahghs1 128 10 out out IN cord-309161-ceahghs1 128 11 of of IN cord-309161-ceahghs1 128 12 convenience convenience NN cord-309161-ceahghs1 128 13 of of IN cord-309161-ceahghs1 128 14 availability availability NN cord-309161-ceahghs1 128 15 , , , cord-309161-ceahghs1 128 16 but but CC cord-309161-ceahghs1 128 17 there there EX cord-309161-ceahghs1 128 18 is be VBZ cord-309161-ceahghs1 128 19 exciting exciting JJ cord-309161-ceahghs1 128 20 potential potential NN cord-309161-ceahghs1 128 21 to to TO cord-309161-ceahghs1 128 22 develop develop VB cord-309161-ceahghs1 128 23 further further JJ cord-309161-ceahghs1 128 24 translational translational JJ cord-309161-ceahghs1 128 25 measures measure NNS cord-309161-ceahghs1 128 26 based base VBN cord-309161-ceahghs1 128 27 more more RBR cord-309161-ceahghs1 128 28 directly directly RB cord-309161-ceahghs1 128 29 on on IN cord-309161-ceahghs1 128 30 the the DT cord-309161-ceahghs1 128 31 basic basic JJ cord-309161-ceahghs1 128 32 mechanisms mechanism NNS cord-309161-ceahghs1 128 33 of of IN cord-309161-ceahghs1 128 34 aging age VBG cord-309161-ceahghs1 128 35 . . . cord-309161-ceahghs1 129 1 This this DT cord-309161-ceahghs1 129 2 admittedly admittedly RB cord-309161-ceahghs1 129 3 requires require VBZ cord-309161-ceahghs1 129 4 high high JJ cord-309161-ceahghs1 129 5 intensity intensity NN cord-309161-ceahghs1 129 6 collaboration collaboration NN cord-309161-ceahghs1 129 7 between between IN cord-309161-ceahghs1 129 8 basic basic JJ cord-309161-ceahghs1 129 9 and and CC cord-309161-ceahghs1 129 10 clinical clinical JJ cord-309161-ceahghs1 129 11 scientists scientist NNS cord-309161-ceahghs1 129 12 ( ( -LRB- cord-309161-ceahghs1 129 13 eg eg RB cord-309161-ceahghs1 129 14 , , , cord-309161-ceahghs1 129 15 assessments assessment NNS cord-309161-ceahghs1 129 16 of of IN cord-309161-ceahghs1 129 17 mTOR mTOR NNP cord-309161-ceahghs1 129 18 activity activity NN cord-309161-ceahghs1 129 19 , , , cord-309161-ceahghs1 129 20 senescent senescent JJ cord-309161-ceahghs1 129 21 cells cell NNS cord-309161-ceahghs1 129 22 , , , cord-309161-ceahghs1 129 23 mitochondrial mitochondrial JJ cord-309161-ceahghs1 129 24 functioning function VBG cord-309161-ceahghs1 129 25 ) ) -RRB- cord-309161-ceahghs1 129 26 . . . cord-309161-ceahghs1 130 1 2.3 2.3 CD cord-309161-ceahghs1 130 2 Speed speed NN cord-309161-ceahghs1 130 3 of of IN cord-309161-ceahghs1 130 4 recovery recovery NN cord-309161-ceahghs1 130 5 as as IN cord-309161-ceahghs1 130 6 a a DT cord-309161-ceahghs1 130 7 novel novel JJ cord-309161-ceahghs1 130 8 measure measure NN cord-309161-ceahghs1 130 9 of of IN cord-309161-ceahghs1 130 10 latent latent JJ cord-309161-ceahghs1 130 11 aging aging NN cord-309161-ceahghs1 130 12 at at IN cord-309161-ceahghs1 130 13 any any DT cord-309161-ceahghs1 130 14 age age NN cord-309161-ceahghs1 130 15 . . . cord-309161-ceahghs1 131 1 Geroscience Geroscience NNP cord-309161-ceahghs1 131 2 recognizes recognize VBZ cord-309161-ceahghs1 131 3 that that IN cord-309161-ceahghs1 131 4 physiological physiological JJ cord-309161-ceahghs1 131 5 adaptation adaptation NN cord-309161-ceahghs1 131 6 to to TO cord-309161-ceahghs1 131 7 stress stress NN cord-309161-ceahghs1 131 8 stands stand VBZ cord-309161-ceahghs1 131 9 out out RP cord-309161-ceahghs1 131 10 as as IN cord-309161-ceahghs1 131 11 a a DT cord-309161-ceahghs1 131 12 common common JJ cord-309161-ceahghs1 131 13 phenotype phenotype NN cord-309161-ceahghs1 131 14 of of IN cord-309161-ceahghs1 131 15 aging age VBG cord-309161-ceahghs1 131 16 J J NNP cord-309161-ceahghs1 131 17 o o NN cord-309161-ceahghs1 131 18 u u NN cord-309161-ceahghs1 131 19 r r NN cord-309161-ceahghs1 131 20 n n NN cord-309161-ceahghs1 131 21 a a DT cord-309161-ceahghs1 131 22 l l NN cord-309161-ceahghs1 131 23 P p NN cord-309161-ceahghs1 131 24 r r NN cord-309161-ceahghs1 131 25 e e NN cord-309161-ceahghs1 131 26 -p -p NN cord-309161-ceahghs1 132 1 r r NN cord-309161-ceahghs1 132 2 o o NN cord-309161-ceahghs1 132 3 o o NN cord-309161-ceahghs1 132 4 f f NN cord-309161-ceahghs1 132 5 across across IN cord-309161-ceahghs1 132 6 model model NN cord-309161-ceahghs1 132 7 systems system NNS cord-309161-ceahghs1 132 8 of of IN cord-309161-ceahghs1 132 9 aging age VBG cord-309161-ceahghs1 132 10 . . . cord-309161-ceahghs1 133 1 Stress stress NN cord-309161-ceahghs1 133 2 resilience resilience NN cord-309161-ceahghs1 133 3 , , , cord-309161-ceahghs1 133 4 and and CC cord-309161-ceahghs1 133 5 its -PRON- PRP$ cord-309161-ceahghs1 133 6 impairment impairment NN cord-309161-ceahghs1 133 7 , , , cord-309161-ceahghs1 133 8 is be VBZ cord-309161-ceahghs1 133 9 partly partly RB cord-309161-ceahghs1 133 10 an an DT cord-309161-ceahghs1 133 11 outcome outcome NN cord-309161-ceahghs1 133 12 of of IN cord-309161-ceahghs1 133 13 the the DT cord-309161-ceahghs1 133 14 social social JJ cord-309161-ceahghs1 133 15 hallmarks hallmark NNS cord-309161-ceahghs1 133 16 of of IN cord-309161-ceahghs1 133 17 aging age VBG cord-309161-ceahghs1 133 18 , , , cord-309161-ceahghs1 133 19 and and CC cord-309161-ceahghs1 133 20 a a DT cord-309161-ceahghs1 133 21 common common JJ cord-309161-ceahghs1 133 22 underlying underlying JJ cord-309161-ceahghs1 133 23 process process NN cord-309161-ceahghs1 133 24 that that WDT cord-309161-ceahghs1 133 25 in in IN cord-309161-ceahghs1 133 26 part part NN cord-309161-ceahghs1 133 27 regulates regulate VBZ cord-309161-ceahghs1 133 28 the the DT cord-309161-ceahghs1 133 29 cellular cellular JJ cord-309161-ceahghs1 133 30 hallmarks hallmark NNS cord-309161-ceahghs1 133 31 of of IN cord-309161-ceahghs1 133 32 aging age VBG cord-309161-ceahghs1 133 33 . . . cord-309161-ceahghs1 134 1 Snapshot snapshot JJ cord-309161-ceahghs1 134 2 one one CD cord-309161-ceahghs1 134 3 - - HYPH cord-309161-ceahghs1 134 4 time time NN cord-309161-ceahghs1 134 5 measures measure NNS cord-309161-ceahghs1 134 6 of of IN cord-309161-ceahghs1 134 7 aging age VBG cord-309161-ceahghs1 134 8 based base VBN cord-309161-ceahghs1 134 9 on on IN cord-309161-ceahghs1 134 10 blood blood NN cord-309161-ceahghs1 134 11 have have VBP cord-309161-ceahghs1 134 12 inherent inherent JJ cord-309161-ceahghs1 134 13 limitations limitation NNS cord-309161-ceahghs1 134 14 in in IN cord-309161-ceahghs1 134 15 that that IN cord-309161-ceahghs1 134 16 they -PRON- PRP cord-309161-ceahghs1 134 17 do do VBP cord-309161-ceahghs1 134 18 not not RB cord-309161-ceahghs1 134 19 directly directly RB cord-309161-ceahghs1 134 20 test test VB cord-309161-ceahghs1 134 21 how how WRB cord-309161-ceahghs1 134 22 a a DT cord-309161-ceahghs1 134 23 person person NN cord-309161-ceahghs1 134 24 responds respond VBZ cord-309161-ceahghs1 134 25 to to IN cord-309161-ceahghs1 134 26 an an DT cord-309161-ceahghs1 134 27 acute acute JJ cord-309161-ceahghs1 134 28 stressor stressor NN cord-309161-ceahghs1 134 29 . . . cord-309161-ceahghs1 135 1 Recovery recovery NN cord-309161-ceahghs1 135 2 from from IN cord-309161-ceahghs1 135 3 challenge challenge NN cord-309161-ceahghs1 135 4 is be VBZ cord-309161-ceahghs1 135 5 a a DT cord-309161-ceahghs1 135 6 critical critical JJ cord-309161-ceahghs1 135 7 measure measure NN cord-309161-ceahghs1 135 8 of of IN cord-309161-ceahghs1 135 9 stress stress NN cord-309161-ceahghs1 135 10 resilience resilience NN cord-309161-ceahghs1 135 11 that that WDT cord-309161-ceahghs1 135 12 may may MD cord-309161-ceahghs1 135 13 be be VB cord-309161-ceahghs1 135 14 important important JJ cord-309161-ceahghs1 135 15 , , , cord-309161-ceahghs1 135 16 as as IN cord-309161-ceahghs1 135 17 it -PRON- PRP cord-309161-ceahghs1 135 18 assesses assess VBZ cord-309161-ceahghs1 135 19 the the DT cord-309161-ceahghs1 135 20 latent latent JJ cord-309161-ceahghs1 135 21 homeostatic homeostatic JJ cord-309161-ceahghs1 135 22 capacity capacity NN cord-309161-ceahghs1 135 23 of of IN cord-309161-ceahghs1 135 24 a a DT cord-309161-ceahghs1 135 25 system system NN cord-309161-ceahghs1 135 26 . . . cord-309161-ceahghs1 136 1 Speed speed NN cord-309161-ceahghs1 136 2 of of IN cord-309161-ceahghs1 136 3 recovery recovery NN cord-309161-ceahghs1 136 4 is be VBZ cord-309161-ceahghs1 136 5 thought think VBN cord-309161-ceahghs1 136 6 of of IN cord-309161-ceahghs1 136 7 as as RB cord-309161-ceahghs1 136 8 intrinsic intrinsic JJ cord-309161-ceahghs1 136 9 homeostatic homeostatic JJ cord-309161-ceahghs1 136 10 capacity capacity NN cord-309161-ceahghs1 136 11 , , , cord-309161-ceahghs1 136 12 a a DT cord-309161-ceahghs1 136 13 latent latent JJ cord-309161-ceahghs1 136 14 capacity capacity NN cord-309161-ceahghs1 136 15 that that WDT cord-309161-ceahghs1 136 16 reflects reflect VBZ cord-309161-ceahghs1 136 17 biological biological JJ cord-309161-ceahghs1 136 18 aging aging NN cord-309161-ceahghs1 136 19 . . . cord-309161-ceahghs1 137 1 Recovery recovery NN cord-309161-ceahghs1 137 2 is be VBZ cord-309161-ceahghs1 137 3 such such PDT cord-309161-ceahghs1 137 4 an an DT cord-309161-ceahghs1 137 5 important important JJ cord-309161-ceahghs1 137 6 marker marker NN cord-309161-ceahghs1 137 7 of of IN cord-309161-ceahghs1 137 8 aging age VBG cord-309161-ceahghs1 137 9 that that IN cord-309161-ceahghs1 137 10 it -PRON- PRP cord-309161-ceahghs1 137 11 is be VBZ cord-309161-ceahghs1 137 12 central central JJ cord-309161-ceahghs1 137 13 to to IN cord-309161-ceahghs1 137 14 the the DT cord-309161-ceahghs1 137 15 emerging emerge VBG cord-309161-ceahghs1 137 16 areas area NNS cord-309161-ceahghs1 137 17 of of IN cord-309161-ceahghs1 137 18 ' ' `` cord-309161-ceahghs1 137 19 physiological physiological JJ cord-309161-ceahghs1 137 20 geroscience geroscience NN cord-309161-ceahghs1 137 21 " " '' cord-309161-ceahghs1 137 22 and and CC cord-309161-ceahghs1 137 23 " " `` cord-309161-ceahghs1 137 24 translational translational JJ cord-309161-ceahghs1 137 25 geroscience geroscience NN cord-309161-ceahghs1 137 26 . . . cord-309161-ceahghs1 137 27 " " '' cord-309161-ceahghs1 138 1 Naturalistically naturalistically RB cord-309161-ceahghs1 138 2 , , , cord-309161-ceahghs1 138 3 acute acute JJ cord-309161-ceahghs1 138 4 events event NNS cord-309161-ceahghs1 138 5 often often RB cord-309161-ceahghs1 138 6 precede precede VBP cord-309161-ceahghs1 138 7 a a DT cord-309161-ceahghs1 138 8 rapid rapid JJ cord-309161-ceahghs1 138 9 decline decline NN cord-309161-ceahghs1 138 10 in in IN cord-309161-ceahghs1 138 11 function function NN cord-309161-ceahghs1 138 12 , , , cord-309161-ceahghs1 138 13 reflecting reflect VBG cord-309161-ceahghs1 138 14 lack lack NN cord-309161-ceahghs1 138 15 of of IN cord-309161-ceahghs1 138 16 stress stress NN cord-309161-ceahghs1 138 17 resilience resilience NN cord-309161-ceahghs1 138 18 . . . cord-309161-ceahghs1 139 1 For for IN cord-309161-ceahghs1 139 2 example example NN cord-309161-ceahghs1 139 3 , , , cord-309161-ceahghs1 139 4 50 50 CD cord-309161-ceahghs1 139 5 % % NN cord-309161-ceahghs1 139 6 of of IN cord-309161-ceahghs1 139 7 new new JJ cord-309161-ceahghs1 139 8 disabilities disability NNS cord-309161-ceahghs1 139 9 develop develop VBP cord-309161-ceahghs1 139 10 after after IN cord-309161-ceahghs1 139 11 an an DT cord-309161-ceahghs1 139 12 acute acute JJ cord-309161-ceahghs1 139 13 accident accident NN cord-309161-ceahghs1 139 14 or or CC cord-309161-ceahghs1 139 15 illness illness NN cord-309161-ceahghs1 139 16 and and CC cord-309161-ceahghs1 139 17 hospitalization hospitalization NN cord-309161-ceahghs1 140 1 ( ( -LRB- cord-309161-ceahghs1 140 2 Gill Gill NNP cord-309161-ceahghs1 140 3 et et NNP cord-309161-ceahghs1 140 4 al al NNP cord-309161-ceahghs1 140 5 . . NNP cord-309161-ceahghs1 140 6 , , , cord-309161-ceahghs1 140 7 2004 2004 CD cord-309161-ceahghs1 140 8 ) ) -RRB- cord-309161-ceahghs1 140 9 . . . cord-309161-ceahghs1 141 1 There there EX cord-309161-ceahghs1 141 2 are be VBP cord-309161-ceahghs1 141 3 many many JJ cord-309161-ceahghs1 141 4 examples example NNS cord-309161-ceahghs1 141 5 of of IN cord-309161-ceahghs1 141 6 paradigms paradigm NNS cord-309161-ceahghs1 141 7 measuring measure VBG cord-309161-ceahghs1 141 8 recovery recovery NN cord-309161-ceahghs1 141 9 that that WDT cord-309161-ceahghs1 141 10 have have VBP cord-309161-ceahghs1 141 11 validated validate VBN cord-309161-ceahghs1 141 12 the the DT cord-309161-ceahghs1 141 13 importance importance NN cord-309161-ceahghs1 141 14 of of IN cord-309161-ceahghs1 141 15 using use VBG cord-309161-ceahghs1 141 16 a a DT cord-309161-ceahghs1 141 17 challenge challenge NN cord-309161-ceahghs1 141 18 , , , cord-309161-ceahghs1 141 19 and and CC cord-309161-ceahghs1 141 20 measuring measure VBG cord-309161-ceahghs1 141 21 functional functional JJ cord-309161-ceahghs1 141 22 or or CC cord-309161-ceahghs1 141 23 biological biological JJ cord-309161-ceahghs1 141 24 recovery recovery NN cord-309161-ceahghs1 141 25 from from IN cord-309161-ceahghs1 141 26 the the DT cord-309161-ceahghs1 141 27 challenge challenge NN cord-309161-ceahghs1 141 28 . . . cord-309161-ceahghs1 142 1 Frailty frailty NN cord-309161-ceahghs1 142 2 is be VBZ cord-309161-ceahghs1 142 3 a a DT cord-309161-ceahghs1 142 4 measure measure NN cord-309161-ceahghs1 142 5 of of IN cord-309161-ceahghs1 142 6 advanced advanced JJ cord-309161-ceahghs1 142 7 biological biological JJ cord-309161-ceahghs1 142 8 age age NN cord-309161-ceahghs1 142 9 that that WDT cord-309161-ceahghs1 142 10 reflects reflect VBZ cord-309161-ceahghs1 142 11 loss loss NN cord-309161-ceahghs1 142 12 of of IN cord-309161-ceahghs1 142 13 stress stress NN cord-309161-ceahghs1 142 14 resilience resilience NN cord-309161-ceahghs1 142 15 due due IN cord-309161-ceahghs1 142 16 to to IN cord-309161-ceahghs1 142 17 age age NN cord-309161-ceahghs1 142 18 related relate VBN cord-309161-ceahghs1 142 19 decline decline NN cord-309161-ceahghs1 142 20 in in IN cord-309161-ceahghs1 142 21 physiological physiological JJ cord-309161-ceahghs1 142 22 reserve reserve NN cord-309161-ceahghs1 142 23 ( ( -LRB- cord-309161-ceahghs1 142 24 Hoogendijk Hoogendijk NNP cord-309161-ceahghs1 142 25 et et NNP cord-309161-ceahghs1 142 26 al al NNP cord-309161-ceahghs1 142 27 . . NNP cord-309161-ceahghs1 142 28 , , , cord-309161-ceahghs1 142 29 2019 2019 CD cord-309161-ceahghs1 142 30 ) ) -RRB- cord-309161-ceahghs1 142 31 . . . cord-309161-ceahghs1 143 1 However however RB cord-309161-ceahghs1 143 2 , , , cord-309161-ceahghs1 143 3 frailty frailty NN cord-309161-ceahghs1 143 4 is be VBZ cord-309161-ceahghs1 143 5 a a DT cord-309161-ceahghs1 143 6 final final JJ cord-309161-ceahghs1 143 7 common common JJ cord-309161-ceahghs1 143 8 pathway pathway NN cord-309161-ceahghs1 143 9 , , , cord-309161-ceahghs1 143 10 one one NN cord-309161-ceahghs1 143 11 that that WDT cord-309161-ceahghs1 143 12 is be VBZ cord-309161-ceahghs1 143 13 probably probably RB cord-309161-ceahghs1 143 14 not not RB cord-309161-ceahghs1 143 15 reversible reversible JJ cord-309161-ceahghs1 143 16 . . . cord-309161-ceahghs1 144 1 Stress stress NN cord-309161-ceahghs1 144 2 resilience resilience NN cord-309161-ceahghs1 144 3 interventions intervention NNS cord-309161-ceahghs1 144 4 will will MD cord-309161-ceahghs1 144 5 need need VB cord-309161-ceahghs1 144 6 to to TO cord-309161-ceahghs1 144 7 target target VB cord-309161-ceahghs1 144 8 people people NNS cord-309161-ceahghs1 144 9 earlier early RBR cord-309161-ceahghs1 144 10 in in IN cord-309161-ceahghs1 144 11 life life NN cord-309161-ceahghs1 144 12 long long RB cord-309161-ceahghs1 144 13 before before IN cord-309161-ceahghs1 144 14 frailty frailty NN cord-309161-ceahghs1 144 15 sets set NNS cord-309161-ceahghs1 144 16 in in RP cord-309161-ceahghs1 144 17 . . . cord-309161-ceahghs1 145 1 In in IN cord-309161-ceahghs1 145 2 contrast contrast JJ cord-309161-ceahghs1 145 3 physiological physiological JJ cord-309161-ceahghs1 145 4 resilience resilience NN cord-309161-ceahghs1 145 5 , , , cord-309161-ceahghs1 145 6 which which WDT cord-309161-ceahghs1 145 7 refers refer VBZ cord-309161-ceahghs1 145 8 to to TO cord-309161-ceahghs1 145 9 ability ability NN cord-309161-ceahghs1 145 10 to to TO cord-309161-ceahghs1 145 11 bounce bounce VB cord-309161-ceahghs1 145 12 back back RB cord-309161-ceahghs1 145 13 from from IN cord-309161-ceahghs1 145 14 a a DT cord-309161-ceahghs1 145 15 stressor stressor NN cord-309161-ceahghs1 145 16 , , , cord-309161-ceahghs1 145 17 is be VBZ cord-309161-ceahghs1 145 18 measurable measurable JJ cord-309161-ceahghs1 145 19 at at IN cord-309161-ceahghs1 145 20 any any DT cord-309161-ceahghs1 145 21 age age NN cord-309161-ceahghs1 145 22 ( ( -LRB- cord-309161-ceahghs1 145 23 Whitson Whitson NNP cord-309161-ceahghs1 145 24 et et FW cord-309161-ceahghs1 145 25 al al NNP cord-309161-ceahghs1 145 26 . . NNP cord-309161-ceahghs1 145 27 , , , cord-309161-ceahghs1 145 28 2016 2016 CD cord-309161-ceahghs1 146 1 ( ( -LRB- cord-309161-ceahghs1 146 2 Whitson Whitson NNP cord-309161-ceahghs1 146 3 et et FW cord-309161-ceahghs1 146 4 al al NNP cord-309161-ceahghs1 146 5 . . NNP cord-309161-ceahghs1 146 6 , , , cord-309161-ceahghs1 146 7 , , , cord-309161-ceahghs1 146 8 2018 2018 CD cord-309161-ceahghs1 146 9 . . . cord-309161-ceahghs1 147 1 Stress stress NN cord-309161-ceahghs1 147 2 resilience resilience NN cord-309161-ceahghs1 147 3 depends depend VBZ cord-309161-ceahghs1 147 4 in in IN cord-309161-ceahghs1 147 5 part part NN cord-309161-ceahghs1 147 6 on on IN cord-309161-ceahghs1 147 7 the the DT cord-309161-ceahghs1 147 8 pre pre JJ cord-309161-ceahghs1 147 9 - - JJ cord-309161-ceahghs1 147 10 existing existing JJ cord-309161-ceahghs1 147 11 level level NN cord-309161-ceahghs1 147 12 of of IN cord-309161-ceahghs1 147 13 reserve reserve NN cord-309161-ceahghs1 147 14 capacity capacity NN cord-309161-ceahghs1 147 15 , , , cord-309161-ceahghs1 147 16 the the DT cord-309161-ceahghs1 147 17 positive positive JJ cord-309161-ceahghs1 147 18 protective protective JJ cord-309161-ceahghs1 147 19 factors factor NNS cord-309161-ceahghs1 147 20 of of IN cord-309161-ceahghs1 147 21 an an DT cord-309161-ceahghs1 147 22 organism organism NN cord-309161-ceahghs1 147 23 , , , cord-309161-ceahghs1 147 24 as as RB cord-309161-ceahghs1 147 25 well well RB cord-309161-ceahghs1 147 26 as as IN cord-309161-ceahghs1 147 27 the the DT cord-309161-ceahghs1 147 28 immediate immediate JJ cord-309161-ceahghs1 147 29 adaptive adaptive JJ cord-309161-ceahghs1 147 30 psychological psychological JJ cord-309161-ceahghs1 147 31 response response NN cord-309161-ceahghs1 147 32 to to IN cord-309161-ceahghs1 147 33 stressors stressor NNS cord-309161-ceahghs1 147 34 ( ( -LRB- cord-309161-ceahghs1 147 35 cognitive cognitive JJ cord-309161-ceahghs1 147 36 appraisals appraisal NNS cord-309161-ceahghs1 147 37 ) ) -RRB- cord-309161-ceahghs1 147 38 . . . cord-309161-ceahghs1 148 1 In in IN cord-309161-ceahghs1 148 2 the the DT cord-309161-ceahghs1 148 3 stress stress NN cord-309161-ceahghs1 148 4 literature literature NN cord-309161-ceahghs1 148 5 , , , cord-309161-ceahghs1 148 6 reserve reserve NN cord-309161-ceahghs1 148 7 capacity capacity NN cord-309161-ceahghs1 148 8 has have VBZ cord-309161-ceahghs1 148 9 been be VBN cord-309161-ceahghs1 148 10 defined define VBN cord-309161-ceahghs1 148 11 as as IN cord-309161-ceahghs1 148 12 J J NNP cord-309161-ceahghs1 148 13 o o NNP cord-309161-ceahghs1 149 1 u u NNP cord-309161-ceahghs1 149 2 r r NNP cord-309161-ceahghs1 149 3 n n NN cord-309161-ceahghs1 149 4 a a DT cord-309161-ceahghs1 149 5 l l NN cord-309161-ceahghs1 149 6 P p NN cord-309161-ceahghs1 149 7 r r NN cord-309161-ceahghs1 149 8 e e NN cord-309161-ceahghs1 150 1 -p -p : cord-309161-ceahghs1 151 1 r r NNP cord-309161-ceahghs1 151 2 o o NN cord-309161-ceahghs1 151 3 o o NN cord-309161-ceahghs1 151 4 f f NN cord-309161-ceahghs1 151 5 combination combination NN cord-309161-ceahghs1 151 6 of of IN cord-309161-ceahghs1 151 7 personal personal JJ cord-309161-ceahghs1 151 8 resources resource NNS cord-309161-ceahghs1 151 9 such such JJ cord-309161-ceahghs1 151 10 as as IN cord-309161-ceahghs1 151 11 optimism optimism NN cord-309161-ceahghs1 151 12 and and CC cord-309161-ceahghs1 151 13 sense sense NN cord-309161-ceahghs1 151 14 of of IN cord-309161-ceahghs1 151 15 control control NN cord-309161-ceahghs1 151 16 , , , cord-309161-ceahghs1 151 17 and and CC cord-309161-ceahghs1 151 18 social social JJ cord-309161-ceahghs1 151 19 factors factor NNS cord-309161-ceahghs1 151 20 such such JJ cord-309161-ceahghs1 151 21 as as IN cord-309161-ceahghs1 151 22 social social JJ cord-309161-ceahghs1 151 23 support support NN cord-309161-ceahghs1 151 24 . . . cord-309161-ceahghs1 152 1 High high JJ cord-309161-ceahghs1 152 2 psychosocial psychosocial JJ cord-309161-ceahghs1 152 3 reserve reserve NN cord-309161-ceahghs1 152 4 capacity capacity NN cord-309161-ceahghs1 152 5 appears appear VBZ cord-309161-ceahghs1 152 6 to to TO cord-309161-ceahghs1 152 7 buffer buffer VB cord-309161-ceahghs1 152 8 those those DT cord-309161-ceahghs1 152 9 from from IN cord-309161-ceahghs1 152 10 low low JJ cord-309161-ceahghs1 152 11 SES ses NN cord-309161-ceahghs1 152 12 backgrounds background NNS cord-309161-ceahghs1 152 13 from from IN cord-309161-ceahghs1 152 14 developing develop VBG cord-309161-ceahghs1 152 15 cardiovascular cardiovascular JJ cord-309161-ceahghs1 152 16 disease disease NN cord-309161-ceahghs1 152 17 ( ( -LRB- cord-309161-ceahghs1 152 18 Matthews Matthews NNP cord-309161-ceahghs1 152 19 et et NNP cord-309161-ceahghs1 152 20 al al NNP cord-309161-ceahghs1 152 21 . . NNP cord-309161-ceahghs1 152 22 , , , cord-309161-ceahghs1 152 23 2008 2008 CD cord-309161-ceahghs1 152 24 ) ) -RRB- cord-309161-ceahghs1 152 25 . . . cord-309161-ceahghs1 153 1 In in IN cord-309161-ceahghs1 153 2 geroscience geroscience NN cord-309161-ceahghs1 153 3 , , , cord-309161-ceahghs1 153 4 reserve reserve NN cord-309161-ceahghs1 153 5 capacity capacity NN cord-309161-ceahghs1 153 6 refers refer VBZ cord-309161-ceahghs1 153 7 to to IN cord-309161-ceahghs1 153 8 a a DT cord-309161-ceahghs1 153 9 broader broad JJR cord-309161-ceahghs1 153 10 set set NN cord-309161-ceahghs1 153 11 of of IN cord-309161-ceahghs1 153 12 resources resource NNS cord-309161-ceahghs1 153 13 of of IN cord-309161-ceahghs1 153 14 or or CC cord-309161-ceahghs1 153 15 buffers buffer NNS cord-309161-ceahghs1 153 16 , , , cord-309161-ceahghs1 153 17 social social JJ cord-309161-ceahghs1 153 18 , , , cord-309161-ceahghs1 153 19 psychological psychological JJ cord-309161-ceahghs1 153 20 or or CC cord-309161-ceahghs1 153 21 physiological physiological JJ cord-309161-ceahghs1 153 22 including include VBG cord-309161-ceahghs1 153 23 cognitive cognitive JJ cord-309161-ceahghs1 153 24 function function NN cord-309161-ceahghs1 153 25 ( ( -LRB- cord-309161-ceahghs1 153 26 e.g. e.g. RB cord-309161-ceahghs1 153 27 , , , cord-309161-ceahghs1 153 28 high high JJ cord-309161-ceahghs1 153 29 IQ iq NN cord-309161-ceahghs1 153 30 ) ) -RRB- cord-309161-ceahghs1 153 31 , , , cord-309161-ceahghs1 153 32 physiological physiological JJ cord-309161-ceahghs1 153 33 ( ( -LRB- cord-309161-ceahghs1 153 34 e.g. e.g. RB cord-309161-ceahghs1 153 35 , , , cord-309161-ceahghs1 153 36 aerobic aerobic JJ cord-309161-ceahghs1 153 37 fitness fitness NN cord-309161-ceahghs1 153 38 , , , cord-309161-ceahghs1 153 39 sleep sleep NN cord-309161-ceahghs1 153 40 ) ) -RRB- cord-309161-ceahghs1 153 41 , , , cord-309161-ceahghs1 153 42 and and CC cord-309161-ceahghs1 153 43 psychological psychological JJ cord-309161-ceahghs1 153 44 assets asset NNS cord-309161-ceahghs1 153 45 ( ( -LRB- cord-309161-ceahghs1 153 46 e.g. e.g. RB cord-309161-ceahghs1 153 47 , , , cord-309161-ceahghs1 153 48 high high JJ cord-309161-ceahghs1 153 49 optimism optimism NN cord-309161-ceahghs1 153 50 or or CC cord-309161-ceahghs1 153 51 positive positive JJ cord-309161-ceahghs1 153 52 affect affect NN cord-309161-ceahghs1 153 53 ) ) -RRB- cord-309161-ceahghs1 153 54 . . . cord-309161-ceahghs1 154 1 High high JJ cord-309161-ceahghs1 154 2 reserve reserve NN cord-309161-ceahghs1 154 3 capacity capacity NN cord-309161-ceahghs1 154 4 increases increase VBZ cord-309161-ceahghs1 154 5 the the DT cord-309161-ceahghs1 154 6 likelihood likelihood NN cord-309161-ceahghs1 154 7 that that IN cord-309161-ceahghs1 154 8 one one PRP cord-309161-ceahghs1 154 9 will will MD cord-309161-ceahghs1 154 10 have have VB cord-309161-ceahghs1 154 11 a a DT cord-309161-ceahghs1 154 12 hormetic hormetic JJ cord-309161-ceahghs1 154 13 protective protective JJ cord-309161-ceahghs1 154 14 response response NN cord-309161-ceahghs1 154 15 to to IN cord-309161-ceahghs1 154 16 a a DT cord-309161-ceahghs1 154 17 stressor stressor NN cord-309161-ceahghs1 154 18 . . . cord-309161-ceahghs1 155 1 As as IN cord-309161-ceahghs1 155 2 shown show VBN cord-309161-ceahghs1 155 3 in in IN cord-309161-ceahghs1 155 4 Figure figure NN cord-309161-ceahghs1 155 5 2 2 CD cord-309161-ceahghs1 155 6 , , , cord-309161-ceahghs1 155 7 after after IN cord-309161-ceahghs1 155 8 diverse diverse JJ cord-309161-ceahghs1 155 9 types type NNS cord-309161-ceahghs1 155 10 of of IN cord-309161-ceahghs1 155 11 stressors stressor NNS cord-309161-ceahghs1 155 12 ( ( -LRB- cord-309161-ceahghs1 155 13 eg eg IN cord-309161-ceahghs1 155 14 , , , cord-309161-ceahghs1 155 15 chemical chemical JJ cord-309161-ceahghs1 155 16 , , , cord-309161-ceahghs1 155 17 physiological physiological JJ cord-309161-ceahghs1 155 18 or or CC cord-309161-ceahghs1 155 19 psychological psychological JJ cord-309161-ceahghs1 155 20 ) ) -RRB- cord-309161-ceahghs1 155 21 , , , cord-309161-ceahghs1 155 22 an an DT cord-309161-ceahghs1 155 23 organism organism NN cord-309161-ceahghs1 155 24 reacts react VBZ cord-309161-ceahghs1 155 25 and and CC cord-309161-ceahghs1 155 26 recovers recover VBZ cord-309161-ceahghs1 155 27 to to TO cord-309161-ceahghs1 155 28 baseline baseline VB cord-309161-ceahghs1 155 29 with with IN cord-309161-ceahghs1 155 30 different different JJ cord-309161-ceahghs1 155 31 speeds speed NNS cord-309161-ceahghs1 155 32 and and CC cord-309161-ceahghs1 155 33 this this DT cord-309161-ceahghs1 155 34 is be VBZ cord-309161-ceahghs1 155 35 moderated moderate VBN cord-309161-ceahghs1 155 36 by by IN cord-309161-ceahghs1 155 37 baseline baseline JJ cord-309161-ceahghs1 155 38 reserve reserve NN cord-309161-ceahghs1 155 39 capacity capacity NN cord-309161-ceahghs1 155 40 . . . cord-309161-ceahghs1 156 1 For for IN cord-309161-ceahghs1 156 2 example example NN cord-309161-ceahghs1 156 3 , , , cord-309161-ceahghs1 156 4 in in IN cord-309161-ceahghs1 156 5 response response NN cord-309161-ceahghs1 156 6 to to IN cord-309161-ceahghs1 156 7 a a DT cord-309161-ceahghs1 156 8 hip hip NN cord-309161-ceahghs1 156 9 replacement replacement NN cord-309161-ceahghs1 156 10 surgery surgery NN cord-309161-ceahghs1 156 11 , , , cord-309161-ceahghs1 156 12 the the DT cord-309161-ceahghs1 156 13 biggest big JJS cord-309161-ceahghs1 156 14 predictor predictor NN cord-309161-ceahghs1 156 15 of of IN cord-309161-ceahghs1 156 16 good good JJ cord-309161-ceahghs1 156 17 recovery recovery NN cord-309161-ceahghs1 156 18 was be VBD cord-309161-ceahghs1 156 19 reporting report VBG cord-309161-ceahghs1 156 20 good good JJ cord-309161-ceahghs1 156 21 physical physical JJ cord-309161-ceahghs1 156 22 function function NN cord-309161-ceahghs1 156 23 at at IN cord-309161-ceahghs1 156 24 baseline baseline NN cord-309161-ceahghs1 156 25 ( ( -LRB- cord-309161-ceahghs1 156 26 Colón Colón NNP cord-309161-ceahghs1 156 27 - - HYPH cord-309161-ceahghs1 156 28 Emeric Emeric NNP cord-309161-ceahghs1 156 29 et et FW cord-309161-ceahghs1 156 30 al al NNP cord-309161-ceahghs1 156 31 . . NNP cord-309161-ceahghs1 156 32 , , , cord-309161-ceahghs1 156 33 2019 2019 CD cord-309161-ceahghs1 156 34 ) ) -RRB- cord-309161-ceahghs1 156 35 . . . cord-309161-ceahghs1 157 1 In in IN cord-309161-ceahghs1 157 2 response response NN cord-309161-ceahghs1 157 3 to to IN cord-309161-ceahghs1 157 4 general general JJ cord-309161-ceahghs1 157 5 anesthesia anesthesia NN cord-309161-ceahghs1 157 6 , , , cord-309161-ceahghs1 157 7 predictors predictor NNS cord-309161-ceahghs1 157 8 of of IN cord-309161-ceahghs1 157 9 protection protection NN cord-309161-ceahghs1 157 10 from from IN cord-309161-ceahghs1 157 11 dementia dementia NN cord-309161-ceahghs1 157 12 and and CC cord-309161-ceahghs1 157 13 other other JJ cord-309161-ceahghs1 157 14 cognitive cognitive JJ cord-309161-ceahghs1 157 15 outcomes outcome NNS cord-309161-ceahghs1 157 16 was be VBD cord-309161-ceahghs1 157 17 measures measure NNS cord-309161-ceahghs1 157 18 of of IN cord-309161-ceahghs1 157 19 cognitive cognitive JJ cord-309161-ceahghs1 157 20 reserve reserve NN cord-309161-ceahghs1 157 21 such such JJ cord-309161-ceahghs1 157 22 as as IN cord-309161-ceahghs1 157 23 education education NN cord-309161-ceahghs1 157 24 and and CC cord-309161-ceahghs1 157 25 vocabulary vocabulary NN cord-309161-ceahghs1 157 26 ability ability NN cord-309161-ceahghs1 158 1 ( ( -LRB- cord-309161-ceahghs1 158 2 Cizginer Cizginer NNP cord-309161-ceahghs1 158 3 et et NNP cord-309161-ceahghs1 158 4 al al NNP cord-309161-ceahghs1 158 5 . . NNP cord-309161-ceahghs1 158 6 , , , cord-309161-ceahghs1 158 7 2017 2017 CD cord-309161-ceahghs1 158 8 ) ) -RRB- cord-309161-ceahghs1 158 9 . . . cord-309161-ceahghs1 159 1 Indices index NNS cord-309161-ceahghs1 159 2 of of IN cord-309161-ceahghs1 159 3 reserve reserve NN cord-309161-ceahghs1 159 4 capacity capacity NN cord-309161-ceahghs1 159 5 in in IN cord-309161-ceahghs1 159 6 functional functional JJ cord-309161-ceahghs1 159 7 abilities ability NNS cord-309161-ceahghs1 159 8 ( ( -LRB- cord-309161-ceahghs1 159 9 such such JJ cord-309161-ceahghs1 159 10 as as IN cord-309161-ceahghs1 159 11 ability ability NN cord-309161-ceahghs1 159 12 to to TO cord-309161-ceahghs1 159 13 stand stand VB cord-309161-ceahghs1 159 14 , , , cord-309161-ceahghs1 159 15 gait gait JJ cord-309161-ceahghs1 159 16 speed speed NN cord-309161-ceahghs1 159 17 , , , cord-309161-ceahghs1 159 18 level level NN cord-309161-ceahghs1 159 19 of of IN cord-309161-ceahghs1 159 20 fitness fitness NN cord-309161-ceahghs1 159 21 ) ) -RRB- cord-309161-ceahghs1 159 22 , , , cord-309161-ceahghs1 159 23 and and CC cord-309161-ceahghs1 159 24 glucose glucose NN cord-309161-ceahghs1 159 25 - - HYPH cord-309161-ceahghs1 159 26 insulin insulin NN cord-309161-ceahghs1 159 27 response response NN cord-309161-ceahghs1 159 28 to to IN cord-309161-ceahghs1 159 29 a a DT cord-309161-ceahghs1 159 30 glucose glucose NN cord-309161-ceahghs1 159 31 load load NN cord-309161-ceahghs1 159 32 , , , cord-309161-ceahghs1 159 33 predict predict VB cord-309161-ceahghs1 159 34 time time NN cord-309161-ceahghs1 159 35 to to IN cord-309161-ceahghs1 159 36 mortality mortality NN cord-309161-ceahghs1 159 37 , , , cord-309161-ceahghs1 159 38 as as IN cord-309161-ceahghs1 159 39 reviewed review VBN cord-309161-ceahghs1 159 40 elsewhere elsewhere RB cord-309161-ceahghs1 159 41 ( ( -LRB- cord-309161-ceahghs1 159 42 Seals Seals NNPS cord-309161-ceahghs1 159 43 & & CC cord-309161-ceahghs1 159 44 Melov Melov NNP cord-309161-ceahghs1 159 45 , , , cord-309161-ceahghs1 159 46 2014 2014 CD cord-309161-ceahghs1 159 47 ) ) -RRB- cord-309161-ceahghs1 159 48 . . . cord-309161-ceahghs1 160 1 One one CD cord-309161-ceahghs1 160 2 of of IN cord-309161-ceahghs1 160 3 the the DT cord-309161-ceahghs1 160 4 most most RBS cord-309161-ceahghs1 160 5 well well RB cord-309161-ceahghs1 160 6 - - HYPH cord-309161-ceahghs1 160 7 developed develop VBN cord-309161-ceahghs1 160 8 areas area NNS cord-309161-ceahghs1 160 9 of of IN cord-309161-ceahghs1 160 10 reserve reserve NN cord-309161-ceahghs1 160 11 capacity capacity NN cord-309161-ceahghs1 160 12 comes come VBZ cord-309161-ceahghs1 160 13 from from IN cord-309161-ceahghs1 160 14 examination examination NN cord-309161-ceahghs1 160 15 of of IN cord-309161-ceahghs1 160 16 individual individual JJ cord-309161-ceahghs1 160 17 dispositions disposition NNS cord-309161-ceahghs1 160 18 of of IN cord-309161-ceahghs1 160 19 temperament temperament NN cord-309161-ceahghs1 160 20 , , , cord-309161-ceahghs1 160 21 typically typically RB cord-309161-ceahghs1 160 22 called call VBN cord-309161-ceahghs1 160 23 personality personality NN cord-309161-ceahghs1 160 24 traits trait NNS cord-309161-ceahghs1 160 25 . . . cord-309161-ceahghs1 161 1 There there EX cord-309161-ceahghs1 161 2 are be VBP cord-309161-ceahghs1 161 3 many many JJ cord-309161-ceahghs1 161 4 psychological psychological JJ cord-309161-ceahghs1 161 5 assets asset NNS cord-309161-ceahghs1 161 6 in in IN cord-309161-ceahghs1 161 7 adulthood adulthood NN cord-309161-ceahghs1 161 8 that that WDT cord-309161-ceahghs1 161 9 are be VBP cord-309161-ceahghs1 161 10 associated associate VBN cord-309161-ceahghs1 161 11 with with IN cord-309161-ceahghs1 161 12 both both DT cord-309161-ceahghs1 161 13 better well JJR cord-309161-ceahghs1 161 14 recovery recovery NN cord-309161-ceahghs1 161 15 from from IN cord-309161-ceahghs1 161 16 stressors stressor NNS cord-309161-ceahghs1 161 17 , , , cord-309161-ceahghs1 161 18 and and CC cord-309161-ceahghs1 161 19 with with IN cord-309161-ceahghs1 161 20 health health NN cord-309161-ceahghs1 161 21 and and CC cord-309161-ceahghs1 161 22 mortality mortality NN cord-309161-ceahghs1 161 23 . . . cord-309161-ceahghs1 162 1 These these DT cord-309161-ceahghs1 162 2 include include VBP cord-309161-ceahghs1 162 3 optimism optimism NN cord-309161-ceahghs1 162 4 , , , cord-309161-ceahghs1 162 5 positive positive JJ cord-309161-ceahghs1 162 6 affect affect NN cord-309161-ceahghs1 162 7 , , , cord-309161-ceahghs1 162 8 mindfulness mindfulness NN cord-309161-ceahghs1 162 9 , , , cord-309161-ceahghs1 162 10 coping cope VBG cord-309161-ceahghs1 162 11 with with IN cord-309161-ceahghs1 162 12 stress stress NN cord-309161-ceahghs1 162 13 with with IN cord-309161-ceahghs1 162 14 cognitive cognitive JJ cord-309161-ceahghs1 162 15 reappraisal reappraisal NN cord-309161-ceahghs1 162 16 or or CC cord-309161-ceahghs1 162 17 active active JJ cord-309161-ceahghs1 162 18 coping coping NN cord-309161-ceahghs1 162 19 , , , cord-309161-ceahghs1 162 20 high high JJ cord-309161-ceahghs1 162 21 presence presence NN cord-309161-ceahghs1 162 22 of of IN cord-309161-ceahghs1 162 23 social social JJ cord-309161-ceahghs1 162 24 support support NN cord-309161-ceahghs1 162 25 or or CC cord-309161-ceahghs1 162 26 seeking seek VBG cord-309161-ceahghs1 162 27 support support NN cord-309161-ceahghs1 162 28 , , , cord-309161-ceahghs1 162 29 purpose purpose NN cord-309161-ceahghs1 162 30 in in IN cord-309161-ceahghs1 162 31 life life NN cord-309161-ceahghs1 162 32 , , , cord-309161-ceahghs1 162 33 and and CC cord-309161-ceahghs1 162 34 quality quality NN cord-309161-ceahghs1 162 35 relationships relationship NNS cord-309161-ceahghs1 162 36 . . . cord-309161-ceahghs1 163 1 Many many JJ cord-309161-ceahghs1 163 2 of of IN cord-309161-ceahghs1 163 3 these these DT cord-309161-ceahghs1 163 4 assets asset NNS cord-309161-ceahghs1 163 5 have have VBP cord-309161-ceahghs1 163 6 been be VBN cord-309161-ceahghs1 163 7 associated associate VBN cord-309161-ceahghs1 163 8 with with IN cord-309161-ceahghs1 163 9 indices index NNS cord-309161-ceahghs1 163 10 of of IN cord-309161-ceahghs1 163 11 good good JJ cord-309161-ceahghs1 163 12 health health NN cord-309161-ceahghs1 163 13 , , , cord-309161-ceahghs1 163 14 such such JJ cord-309161-ceahghs1 163 15 as as IN cord-309161-ceahghs1 163 16 self self NN cord-309161-ceahghs1 163 17 - - HYPH cord-309161-ceahghs1 163 18 reported report VBN cord-309161-ceahghs1 163 19 health health NN cord-309161-ceahghs1 163 20 and and CC cord-309161-ceahghs1 163 21 higher high JJR cord-309161-ceahghs1 163 22 heart heart NN cord-309161-ceahghs1 163 23 rate rate NN cord-309161-ceahghs1 163 24 variability variability NN cord-309161-ceahghs1 164 1 ( ( -LRB- cord-309161-ceahghs1 164 2 Carnevali Carnevali NNP cord-309161-ceahghs1 164 3 et et NNP cord-309161-ceahghs1 164 4 al al NNP cord-309161-ceahghs1 164 5 . . NNP cord-309161-ceahghs1 164 6 , , , cord-309161-ceahghs1 164 7 2018 2018 CD cord-309161-ceahghs1 164 8 ) ) -RRB- cord-309161-ceahghs1 164 9 . . . cord-309161-ceahghs1 165 1 These these DT cord-309161-ceahghs1 165 2 positive positive JJ cord-309161-ceahghs1 165 3 assets asset NNS cord-309161-ceahghs1 165 4 are be VBP cord-309161-ceahghs1 165 5 both both DT cord-309161-ceahghs1 165 6 shaped shape VBN cord-309161-ceahghs1 165 7 by by IN cord-309161-ceahghs1 165 8 genetics genetic NNS cord-309161-ceahghs1 165 9 and and CC cord-309161-ceahghs1 165 10 life life NN cord-309161-ceahghs1 165 11 experience experience NN cord-309161-ceahghs1 165 12 . . . cord-309161-ceahghs1 166 1 will will MD cord-309161-ceahghs1 166 2 promote promote VB cord-309161-ceahghs1 166 3 further further JJ cord-309161-ceahghs1 166 4 positive positive JJ cord-309161-ceahghs1 166 5 responses response NNS cord-309161-ceahghs1 166 6 to to IN cord-309161-ceahghs1 166 7 future future JJ cord-309161-ceahghs1 166 8 stressors stressor NNS cord-309161-ceahghs1 166 9 , , , cord-309161-ceahghs1 166 10 and and CC cord-309161-ceahghs1 166 11 may may MD cord-309161-ceahghs1 166 12 help help VB cord-309161-ceahghs1 166 13 slow slow VB cord-309161-ceahghs1 166 14 the the DT cord-309161-ceahghs1 166 15 rate rate NN cord-309161-ceahghs1 166 16 of of IN cord-309161-ceahghs1 166 17 aging age VBG cord-309161-ceahghs1 166 18 in in IN cord-309161-ceahghs1 166 19 humans human NNS cord-309161-ceahghs1 166 20 , , , cord-309161-ceahghs1 166 21 as as IN cord-309161-ceahghs1 166 22 shown show VBN cord-309161-ceahghs1 166 23 in in IN cord-309161-ceahghs1 166 24 Figure figure NN cord-309161-ceahghs1 166 25 1 1 CD cord-309161-ceahghs1 166 26 . . . cord-309161-ceahghs1 167 1 How how WRB cord-309161-ceahghs1 167 2 can can MD cord-309161-ceahghs1 167 3 we -PRON- PRP cord-309161-ceahghs1 167 4 best well RBS cord-309161-ceahghs1 167 5 translate translate VB cord-309161-ceahghs1 167 6 hormetic hormetic JJ cord-309161-ceahghs1 167 7 interventions intervention NNS cord-309161-ceahghs1 167 8 to to IN cord-309161-ceahghs1 167 9 humans human NNS cord-309161-ceahghs1 167 10 ? ? . cord-309161-ceahghs1 168 1 There there EX cord-309161-ceahghs1 168 2 are be VBP cord-309161-ceahghs1 168 3 many many JJ cord-309161-ceahghs1 168 4 potential potential JJ cord-309161-ceahghs1 168 5 interventions intervention NNS cord-309161-ceahghs1 168 6 that that WDT cord-309161-ceahghs1 168 7 may may MD cord-309161-ceahghs1 168 8 improve improve VB cord-309161-ceahghs1 168 9 stress stress NN cord-309161-ceahghs1 168 10 resilience resilience NN cord-309161-ceahghs1 168 11 , , , cord-309161-ceahghs1 168 12 listed list VBN cord-309161-ceahghs1 168 13 in in IN cord-309161-ceahghs1 168 14 Table Table NNP cord-309161-ceahghs1 168 15 1 1 CD cord-309161-ceahghs1 168 16 . . . cord-309161-ceahghs1 169 1 Lifestyle lifestyle NN cord-309161-ceahghs1 169 2 interventions intervention NNS cord-309161-ceahghs1 169 3 , , , cord-309161-ceahghs1 169 4 such such JJ cord-309161-ceahghs1 169 5 as as IN cord-309161-ceahghs1 169 6 exercise exercise NN cord-309161-ceahghs1 169 7 , , , cord-309161-ceahghs1 169 8 caloric caloric JJ cord-309161-ceahghs1 169 9 restriction restriction NN cord-309161-ceahghs1 169 10 , , , cord-309161-ceahghs1 169 11 intermittent intermittent JJ cord-309161-ceahghs1 169 12 fasting fast VBG cord-309161-ceahghs1 169 13 , , , cord-309161-ceahghs1 169 14 challenging challenge VBG cord-309161-ceahghs1 169 15 cognitive cognitive JJ cord-309161-ceahghs1 169 16 activities activity NNS cord-309161-ceahghs1 169 17 , , , cord-309161-ceahghs1 169 18 and and CC cord-309161-ceahghs1 169 19 response response NN cord-309161-ceahghs1 169 20 to to IN cord-309161-ceahghs1 169 21 phytochemicals phytochemical NNS cord-309161-ceahghs1 169 22 in in IN cord-309161-ceahghs1 169 23 vegetables vegetable NNS cord-309161-ceahghs1 169 24 and and CC cord-309161-ceahghs1 169 25 fruits fruit NNS cord-309161-ceahghs1 169 26 , , , cord-309161-ceahghs1 169 27 are be VBP cord-309161-ceahghs1 169 28 thought think VBN cord-309161-ceahghs1 169 29 to to TO cord-309161-ceahghs1 169 30 work work VB cord-309161-ceahghs1 169 31 in in IN cord-309161-ceahghs1 169 32 part part NN cord-309161-ceahghs1 169 33 through through IN cord-309161-ceahghs1 169 34 hormesis hormesis NN cord-309161-ceahghs1 169 35 ( ( -LRB- cord-309161-ceahghs1 169 36 Mattson Mattson NNP cord-309161-ceahghs1 169 37 , , , cord-309161-ceahghs1 169 38 2008b 2008b CD cord-309161-ceahghs1 169 39 ; ; : cord-309161-ceahghs1 169 40 Radak Radak NNP cord-309161-ceahghs1 169 41 et et NNP cord-309161-ceahghs1 169 42 al al NNP cord-309161-ceahghs1 169 43 . . NNP cord-309161-ceahghs1 169 44 , , , cord-309161-ceahghs1 169 45 2017 2017 CD cord-309161-ceahghs1 169 46 ) ) -RRB- cord-309161-ceahghs1 169 47 . . . cord-309161-ceahghs1 170 1 At at RB cord-309161-ceahghs1 170 2 least least RBS cord-309161-ceahghs1 170 3 one one CD cord-309161-ceahghs1 170 4 group group NN cord-309161-ceahghs1 170 5 is be VBZ cord-309161-ceahghs1 170 6 pilot pilot NN cord-309161-ceahghs1 170 7 testing test VBG cord-309161-ceahghs1 170 8 a a DT cord-309161-ceahghs1 170 9 cocktail cocktail NN cord-309161-ceahghs1 170 10 of of IN cord-309161-ceahghs1 170 11 stressors stressor NNS cord-309161-ceahghs1 170 12 in in IN cord-309161-ceahghs1 170 13 humans human NNS cord-309161-ceahghs1 170 14 to to TO cord-309161-ceahghs1 170 15 examine examine VB cord-309161-ceahghs1 170 16 rejuvenation rejuvenation NN cord-309161-ceahghs1 170 17 effects effect NNS cord-309161-ceahghs1 170 18 , , , cord-309161-ceahghs1 170 19 using use VBG cord-309161-ceahghs1 170 20 intermittent intermittent JJ cord-309161-ceahghs1 170 21 cold cold JJ cord-309161-ceahghs1 170 22 , , , cord-309161-ceahghs1 170 23 heat heat NN cord-309161-ceahghs1 170 24 , , , cord-309161-ceahghs1 170 25 fasting fasting NN cord-309161-ceahghs1 170 26 and and CC cord-309161-ceahghs1 170 27 hypoxia hypoxia NN cord-309161-ceahghs1 170 28 , , , cord-309161-ceahghs1 170 29 together together RB cord-309161-ceahghs1 170 30 with with IN cord-309161-ceahghs1 170 31 phytochemicals phytochemical NNS cord-309161-ceahghs1 170 32 ( ( -LRB- cord-309161-ceahghs1 170 33 Pruimboom Pruimboom NNP cord-309161-ceahghs1 170 34 et et NNP cord-309161-ceahghs1 170 35 al al NNP cord-309161-ceahghs1 170 36 . . NNP cord-309161-ceahghs1 170 37 , , , cord-309161-ceahghs1 170 38 2016 2016 CD cord-309161-ceahghs1 170 39 ) ) -RRB- cord-309161-ceahghs1 170 40 . . . cord-309161-ceahghs1 171 1 The the DT cord-309161-ceahghs1 171 2 hypoxic hypoxic JJ cord-309161-ceahghs1 171 3 preconditioning preconditioning NN cord-309161-ceahghs1 171 4 effect effect NN cord-309161-ceahghs1 171 5 demonstrates demonstrate VBZ cord-309161-ceahghs1 171 6 protection protection NN cord-309161-ceahghs1 171 7 of of IN cord-309161-ceahghs1 171 8 neurons neuron NNS cord-309161-ceahghs1 171 9 and and CC cord-309161-ceahghs1 171 10 cardiac cardiac JJ cord-309161-ceahghs1 171 11 cells cell NNS cord-309161-ceahghs1 171 12 , , , cord-309161-ceahghs1 171 13 and and CC cord-309161-ceahghs1 171 14 is be VBZ cord-309161-ceahghs1 171 15 a a DT cord-309161-ceahghs1 171 16 potential potential JJ cord-309161-ceahghs1 171 17 area area NN cord-309161-ceahghs1 171 18 of of IN cord-309161-ceahghs1 171 19 translation translation NN cord-309161-ceahghs1 172 1 ( ( -LRB- cord-309161-ceahghs1 172 2 Li Li NNP cord-309161-ceahghs1 172 3 et et NNP cord-309161-ceahghs1 172 4 al al NNP cord-309161-ceahghs1 172 5 . . NNP cord-309161-ceahghs1 172 6 , , , cord-309161-ceahghs1 172 7 2017 2017 CD cord-309161-ceahghs1 172 8 ) ) -RRB- cord-309161-ceahghs1 172 9 . . . cord-309161-ceahghs1 173 1 An an DT cord-309161-ceahghs1 173 2 interesting interesting JJ cord-309161-ceahghs1 173 3 novel novel NN cord-309161-ceahghs1 173 4 intervention intervention NN cord-309161-ceahghs1 173 5 inducing induce VBG cord-309161-ceahghs1 173 6 acute acute JJ cord-309161-ceahghs1 173 7 stress stress NN cord-309161-ceahghs1 173 8 ( ( -LRB- cord-309161-ceahghs1 173 9 through through IN cord-309161-ceahghs1 173 10 exposure exposure NN cord-309161-ceahghs1 173 11 to to IN cord-309161-ceahghs1 173 12 intermittent intermittent JJ cord-309161-ceahghs1 173 13 hypoxia hypoxia NN cord-309161-ceahghs1 173 14 and and CC cord-309161-ceahghs1 173 15 cold cold NN cord-309161-ceahghs1 173 16 ) ) -RRB- cord-309161-ceahghs1 173 17 appears appear VBZ cord-309161-ceahghs1 173 18 to to TO cord-309161-ceahghs1 173 19 improve improve VB cord-309161-ceahghs1 173 20 immune immune JJ cord-309161-ceahghs1 173 21 response response NN cord-309161-ceahghs1 173 22 to to IN cord-309161-ceahghs1 173 23 endotoxin endotoxin NN cord-309161-ceahghs1 173 24 at at IN cord-309161-ceahghs1 173 25 least least JJS cord-309161-ceahghs1 173 26 in in IN cord-309161-ceahghs1 173 27 a a DT cord-309161-ceahghs1 173 28 small small JJ cord-309161-ceahghs1 173 29 initial initial JJ cord-309161-ceahghs1 173 30 study study NN cord-309161-ceahghs1 173 31 , , , cord-309161-ceahghs1 173 32 with with IN cord-309161-ceahghs1 173 33 a a DT cord-309161-ceahghs1 173 34 replication replication NN cord-309161-ceahghs1 173 35 underway underway NN cord-309161-ceahghs1 173 36 ( ( -LRB- cord-309161-ceahghs1 173 37 Kox Kox NNP cord-309161-ceahghs1 173 38 et et NNP cord-309161-ceahghs1 173 39 al al NNP cord-309161-ceahghs1 173 40 . . NNP cord-309161-ceahghs1 173 41 , , , cord-309161-ceahghs1 173 42 2014 2014 CD cord-309161-ceahghs1 173 43 ) ) -RRB- cord-309161-ceahghs1 173 44 . . . cord-309161-ceahghs1 174 1 At at IN cord-309161-ceahghs1 174 2 UCSF UCSF NNP cord-309161-ceahghs1 174 3 we -PRON- PRP cord-309161-ceahghs1 174 4 are be VBP cord-309161-ceahghs1 174 5 testing test VBG cord-309161-ceahghs1 174 6 a a DT cord-309161-ceahghs1 174 7 similar similar JJ cord-309161-ceahghs1 174 8 protocol protocol NN cord-309161-ceahghs1 174 9 to to TO cord-309161-ceahghs1 174 10 see see VB cord-309161-ceahghs1 174 11 if if IN cord-309161-ceahghs1 174 12 it -PRON- PRP cord-309161-ceahghs1 174 13 improves improve VBZ cord-309161-ceahghs1 174 14 autonomic autonomic JJ cord-309161-ceahghs1 174 15 and and CC cord-309161-ceahghs1 174 16 neuroendocrine neuroendocrine JJ cord-309161-ceahghs1 174 17 response response NN cord-309161-ceahghs1 174 18 profiles profile NNS cord-309161-ceahghs1 174 19 ( ( -LRB- cord-309161-ceahghs1 174 20 including include VBG cord-309161-ceahghs1 174 21 a a DT cord-309161-ceahghs1 174 22 quicker quick JJR cord-309161-ceahghs1 174 23 recovery recovery NN cord-309161-ceahghs1 174 24 from from IN cord-309161-ceahghs1 174 25 acute acute JJ cord-309161-ceahghs1 174 26 stress stress NN cord-309161-ceahghs1 174 27 ) ) -RRB- cord-309161-ceahghs1 174 28 . . . cord-309161-ceahghs1 175 1 Another another DT cord-309161-ceahghs1 175 2 dramatic dramatic JJ cord-309161-ceahghs1 175 3 way way NN cord-309161-ceahghs1 175 4 to to TO cord-309161-ceahghs1 175 5 increase increase VB cord-309161-ceahghs1 175 6 stress stress NN cord-309161-ceahghs1 175 7 resilience resilience NN cord-309161-ceahghs1 175 8 is be VBZ cord-309161-ceahghs1 175 9 to to TO cord-309161-ceahghs1 175 10 enter enter VB cord-309161-ceahghs1 175 11 periods period NNS cord-309161-ceahghs1 175 12 of of IN cord-309161-ceahghs1 175 13 fasting fasting NN cord-309161-ceahghs1 175 14 , , , cord-309161-ceahghs1 175 15 or or CC cord-309161-ceahghs1 175 16 fasting fast VBG cord-309161-ceahghs1 175 17 mimicking mimic VBG cord-309161-ceahghs1 175 18 with with IN cord-309161-ceahghs1 175 19 low low JJ cord-309161-ceahghs1 175 20 calories calorie NNS cord-309161-ceahghs1 175 21 . . . cord-309161-ceahghs1 176 1 In in IN cord-309161-ceahghs1 176 2 rodents rodent NNS cord-309161-ceahghs1 176 3 , , , cord-309161-ceahghs1 176 4 this this DT cord-309161-ceahghs1 176 5 leads lead VBZ cord-309161-ceahghs1 176 6 to to TO cord-309161-ceahghs1 176 7 stress stress VB cord-309161-ceahghs1 176 8 resistance resistance NN cord-309161-ceahghs1 176 9 and and CC cord-309161-ceahghs1 176 10 regeneration regeneration NN cord-309161-ceahghs1 176 11 and and CC cord-309161-ceahghs1 176 12 rejuvenation rejuvenation NN cord-309161-ceahghs1 176 13 processes process NNS cord-309161-ceahghs1 176 14 through through IN cord-309161-ceahghs1 176 15 hormesis hormesis NN cord-309161-ceahghs1 176 16 , , , cord-309161-ceahghs1 176 17 in in IN cord-309161-ceahghs1 176 18 part part NN cord-309161-ceahghs1 176 19 by by IN cord-309161-ceahghs1 176 20 down down JJ cord-309161-ceahghs1 176 21 regulating regulate VBG cord-309161-ceahghs1 176 22 GH GH NNP cord-309161-ceahghs1 176 23 , , , cord-309161-ceahghs1 176 24 IGF-1 IGF-1 NNP cord-309161-ceahghs1 176 25 . . . cord-309161-ceahghs1 177 1 mTOR mTOR NNP cord-309161-ceahghs1 177 2 , , . cord-309161-ceahghs1 178 1 and and CC cord-309161-ceahghs1 178 2 PKA PKA NNP cord-309161-ceahghs1 178 3 signaling signal VBG cord-309161-ceahghs1 178 4 ( ( -LRB- cord-309161-ceahghs1 178 5 Longo Longo NNP cord-309161-ceahghs1 178 6 , , , cord-309161-ceahghs1 178 7 2019 2019 CD cord-309161-ceahghs1 178 8 ; ; . cord-309161-ceahghs1 179 1 Rangan Rangan NNP cord-309161-ceahghs1 179 2 et et NNP cord-309161-ceahghs1 179 3 al al NNP cord-309161-ceahghs1 179 4 . . NNP cord-309161-ceahghs1 179 5 , , , cord-309161-ceahghs1 179 6 2019 2019 CD cord-309161-ceahghs1 179 7 ) ) -RRB- cord-309161-ceahghs1 179 8 . . . cord-309161-ceahghs1 180 1 Reserve reserve NN cord-309161-ceahghs1 180 2 capacity capacity NN cord-309161-ceahghs1 180 3 is be VBZ cord-309161-ceahghs1 180 4 built build VBN cord-309161-ceahghs1 180 5 during during IN cord-309161-ceahghs1 180 6 formative formative JJ cord-309161-ceahghs1 180 7 developmental developmental JJ cord-309161-ceahghs1 180 8 experiences experience NNS cord-309161-ceahghs1 180 9 , , , cord-309161-ceahghs1 180 10 such such JJ cord-309161-ceahghs1 180 11 as as IN cord-309161-ceahghs1 180 12 level level NN cord-309161-ceahghs1 180 13 of of IN cord-309161-ceahghs1 180 14 education education NN cord-309161-ceahghs1 180 15 , , , cord-309161-ceahghs1 180 16 attachment attachment NN cord-309161-ceahghs1 180 17 relationships relationship NNS cord-309161-ceahghs1 180 18 , , , cord-309161-ceahghs1 180 19 and and CC cord-309161-ceahghs1 180 20 stress stress NN cord-309161-ceahghs1 180 21 exposures exposure NNS cord-309161-ceahghs1 180 22 that that WDT cord-309161-ceahghs1 180 23 shape shape VBP cord-309161-ceahghs1 180 24 the the DT cord-309161-ceahghs1 180 25 neural neural JJ cord-309161-ceahghs1 180 26 architecture architecture NN cord-309161-ceahghs1 180 27 of of IN cord-309161-ceahghs1 180 28 stress stress NN cord-309161-ceahghs1 180 29 responding respond VBG cord-309161-ceahghs1 180 30 , , , cord-309161-ceahghs1 180 31 narratives narrative NNS cord-309161-ceahghs1 180 32 of of IN cord-309161-ceahghs1 180 33 optimism optimism NN cord-309161-ceahghs1 180 34 , , , cord-309161-ceahghs1 180 35 and and CC cord-309161-ceahghs1 180 36 foster foster VB cord-309161-ceahghs1 180 37 positive positive JJ cord-309161-ceahghs1 180 38 challenge challenge NN cord-309161-ceahghs1 180 39 mindsets mindset NNS cord-309161-ceahghs1 180 40 . . . cord-309161-ceahghs1 181 1 One one PRP cord-309161-ceahghs1 181 2 can can MD cord-309161-ceahghs1 181 3 build build VB cord-309161-ceahghs1 181 4 reserve reserve NN cord-309161-ceahghs1 181 5 capacity capacity NN cord-309161-ceahghs1 181 6 by by IN cord-309161-ceahghs1 181 7 increasing increase VBG cord-309161-ceahghs1 181 8 physiological physiological JJ cord-309161-ceahghs1 181 9 buffers buffer NNS cord-309161-ceahghs1 181 10 ( ( -LRB- cord-309161-ceahghs1 181 11 fitness fitness NN cord-309161-ceahghs1 181 12 , , , cord-309161-ceahghs1 181 13 or or CC cord-309161-ceahghs1 181 14 antioxidant antioxidant JJ cord-309161-ceahghs1 181 15 diet diet NN cord-309161-ceahghs1 181 16 ) ) -RRB- cord-309161-ceahghs1 181 17 , , , cord-309161-ceahghs1 181 18 or or CC cord-309161-ceahghs1 181 19 psychological psychological JJ cord-309161-ceahghs1 181 20 stress stress NN cord-309161-ceahghs1 181 21 resilience resilience NN cord-309161-ceahghs1 181 22 , , , cord-309161-ceahghs1 181 23 through through IN cord-309161-ceahghs1 181 24 psychological psychological JJ cord-309161-ceahghs1 181 25 trainings training NNS cord-309161-ceahghs1 181 26 that that WDT cord-309161-ceahghs1 181 27 might may MD cord-309161-ceahghs1 181 28 decreasing decrease VBG cord-309161-ceahghs1 181 29 chronic chronic JJ cord-309161-ceahghs1 181 30 stress stress NN cord-309161-ceahghs1 181 31 arousal arousal NN cord-309161-ceahghs1 181 32 and and CC cord-309161-ceahghs1 181 33 bolster bolster VB cord-309161-ceahghs1 181 34 one one PRP cord-309161-ceahghs1 181 35 's 's POS cord-309161-ceahghs1 181 36 mental mental JJ cord-309161-ceahghs1 181 37 filter filter NN cord-309161-ceahghs1 181 38 so so IN cord-309161-ceahghs1 181 39 they -PRON- PRP cord-309161-ceahghs1 181 40 J J NNP cord-309161-ceahghs1 181 41 o o NNP cord-309161-ceahghs1 182 1 u u NNP cord-309161-ceahghs1 182 2 r r NNP cord-309161-ceahghs1 182 3 n n NN cord-309161-ceahghs1 182 4 a a DT cord-309161-ceahghs1 182 5 l l NN cord-309161-ceahghs1 182 6 P p NN cord-309161-ceahghs1 182 7 r r NN cord-309161-ceahghs1 182 8 e e NN cord-309161-ceahghs1 182 9 -p -p NN cord-309161-ceahghs1 183 1 r r NN cord-309161-ceahghs1 183 2 o o NN cord-309161-ceahghs1 183 3 o o NN cord-309161-ceahghs1 183 4 f f NN cord-309161-ceahghs1 183 5 habitually habitually RB cord-309161-ceahghs1 183 6 perceive perceive VBP cord-309161-ceahghs1 183 7 less less JJR cord-309161-ceahghs1 183 8 threat threat NN cord-309161-ceahghs1 183 9 . . . cord-309161-ceahghs1 184 1 Interventions intervention NNS cord-309161-ceahghs1 184 2 that that WDT cord-309161-ceahghs1 184 3 build build VBP cord-309161-ceahghs1 184 4 psychological psychological JJ cord-309161-ceahghs1 184 5 positive positive JJ cord-309161-ceahghs1 184 6 assets asset NNS cord-309161-ceahghs1 184 7 like like IN cord-309161-ceahghs1 184 8 optimism optimism NN cord-309161-ceahghs1 184 9 , , , cord-309161-ceahghs1 184 10 mastery mastery NN cord-309161-ceahghs1 184 11 , , , cord-309161-ceahghs1 184 12 and and CC cord-309161-ceahghs1 184 13 purpose purpose NN cord-309161-ceahghs1 184 14 in in IN cord-309161-ceahghs1 184 15 life life NN cord-309161-ceahghs1 184 16 need need VBP cord-309161-ceahghs1 184 17 to to TO cord-309161-ceahghs1 184 18 be be VB cord-309161-ceahghs1 184 19 further further RB cord-309161-ceahghs1 184 20 developed develop VBN cord-309161-ceahghs1 184 21 and and CC cord-309161-ceahghs1 184 22 refined refined JJ cord-309161-ceahghs1 184 23 . . . cord-309161-ceahghs1 185 1 Mind mind NN cord-309161-ceahghs1 185 2 - - HYPH cord-309161-ceahghs1 185 3 body body NN cord-309161-ceahghs1 185 4 interventions intervention NNS cord-309161-ceahghs1 185 5 have have VBP cord-309161-ceahghs1 185 6 a a DT cord-309161-ceahghs1 185 7 strong strong JJ cord-309161-ceahghs1 185 8 empirical empirical JJ cord-309161-ceahghs1 185 9 base base NN cord-309161-ceahghs1 185 10 for for IN cord-309161-ceahghs1 185 11 improving improve VBG cord-309161-ceahghs1 185 12 self self NN cord-309161-ceahghs1 185 13 - - HYPH cord-309161-ceahghs1 185 14 reported report VBN cord-309161-ceahghs1 185 15 wellbeing wellbeing NN cord-309161-ceahghs1 185 16 ( ( -LRB- cord-309161-ceahghs1 185 17 Creswell Creswell NNP cord-309161-ceahghs1 185 18 , , , cord-309161-ceahghs1 185 19 2017 2017 CD cord-309161-ceahghs1 185 20 ) ) -RRB- cord-309161-ceahghs1 185 21 with with IN cord-309161-ceahghs1 185 22 mixed mixed JJ cord-309161-ceahghs1 185 23 effects effect NNS cord-309161-ceahghs1 185 24 on on IN cord-309161-ceahghs1 185 25 basal basal NN cord-309161-ceahghs1 185 26 inflammation inflammation NN cord-309161-ceahghs1 185 27 ( ( -LRB- cord-309161-ceahghs1 185 28 Bower Bower NNP cord-309161-ceahghs1 185 29 & & CC cord-309161-ceahghs1 185 30 Irwin Irwin NNP cord-309161-ceahghs1 185 31 , , , cord-309161-ceahghs1 185 32 2016 2016 CD cord-309161-ceahghs1 185 33 ) ) -RRB- cord-309161-ceahghs1 185 34 . . . cord-309161-ceahghs1 186 1 Mindfulness mindfulness NN cord-309161-ceahghs1 186 2 training training NN cord-309161-ceahghs1 186 3 may may MD cord-309161-ceahghs1 186 4 lead lead VB cord-309161-ceahghs1 186 5 to to IN cord-309161-ceahghs1 186 6 changes change NNS cord-309161-ceahghs1 186 7 in in IN cord-309161-ceahghs1 186 8 heart heart NN cord-309161-ceahghs1 186 9 rate rate NN cord-309161-ceahghs1 186 10 variability variability NN cord-309161-ceahghs1 186 11 and and CC cord-309161-ceahghs1 186 12 telomere telomere NN cord-309161-ceahghs1 186 13 biology biology NN cord-309161-ceahghs1 186 14 , , , cord-309161-ceahghs1 186 15 although although IN cord-309161-ceahghs1 186 16 the the DT cord-309161-ceahghs1 186 17 evidence evidence NN cord-309161-ceahghs1 186 18 again again RB cord-309161-ceahghs1 186 19 varies vary VBZ cord-309161-ceahghs1 186 20 by by IN cord-309161-ceahghs1 186 21 population population NN cord-309161-ceahghs1 186 22 and and CC cord-309161-ceahghs1 186 23 study study NN cord-309161-ceahghs1 187 1 ( ( -LRB- cord-309161-ceahghs1 187 2 Rådmark Rådmark NNP cord-309161-ceahghs1 187 3 et et NNP cord-309161-ceahghs1 187 4 al al NNP cord-309161-ceahghs1 187 5 . . NNP cord-309161-ceahghs1 187 6 , , , cord-309161-ceahghs1 187 7 2019 2019 CD cord-309161-ceahghs1 187 8 ) ) -RRB- cord-309161-ceahghs1 188 1 ( ( -LRB- cord-309161-ceahghs1 188 2 Conklin Conklin NNP cord-309161-ceahghs1 188 3 et et NNP cord-309161-ceahghs1 188 4 al al NNP cord-309161-ceahghs1 188 5 . . NNP cord-309161-ceahghs1 188 6 , , , cord-309161-ceahghs1 188 7 2019 2019 CD cord-309161-ceahghs1 188 8 ) ) -RRB- cord-309161-ceahghs1 188 9 and and CC cord-309161-ceahghs1 188 10 appears appear VBZ cord-309161-ceahghs1 188 11 stronger strong JJR cord-309161-ceahghs1 188 12 with with IN cord-309161-ceahghs1 188 13 clinical clinical JJ cord-309161-ceahghs1 188 14 samples sample NNS cord-309161-ceahghs1 188 15 - - , cord-309161-ceahghs1 188 16 those those DT cord-309161-ceahghs1 188 17 with with IN cord-309161-ceahghs1 188 18 high high JJ cord-309161-ceahghs1 188 19 stress stress NN cord-309161-ceahghs1 188 20 or or CC cord-309161-ceahghs1 188 21 early early JJ cord-309161-ceahghs1 188 22 disease disease NN cord-309161-ceahghs1 188 23 . . . cord-309161-ceahghs1 189 1 There there EX cord-309161-ceahghs1 189 2 is be VBZ cord-309161-ceahghs1 189 3 emerging emerge VBG cord-309161-ceahghs1 189 4 evidence evidence NN cord-309161-ceahghs1 189 5 that that IN cord-309161-ceahghs1 189 6 mind mind NN cord-309161-ceahghs1 189 7 - - HYPH cord-309161-ceahghs1 189 8 body body NN cord-309161-ceahghs1 189 9 interventions intervention NNS cord-309161-ceahghs1 189 10 improve improve VBP cord-309161-ceahghs1 189 11 physiological physiological JJ cord-309161-ceahghs1 189 12 acute acute JJ cord-309161-ceahghs1 189 13 stress stress NN cord-309161-ceahghs1 189 14 reactivity reactivity NN cord-309161-ceahghs1 189 15 , , , cord-309161-ceahghs1 189 16 changing change VBG cord-309161-ceahghs1 189 17 stress stress NN cord-309161-ceahghs1 189 18 appraisals appraisal NNS cord-309161-ceahghs1 189 19 and and CC cord-309161-ceahghs1 189 20 physiology physiology NN cord-309161-ceahghs1 189 21 to to IN cord-309161-ceahghs1 189 22 more more JJR cord-309161-ceahghs1 189 23 of of IN cord-309161-ceahghs1 189 24 a a DT cord-309161-ceahghs1 189 25 positive positive JJ cord-309161-ceahghs1 189 26 challenge challenge NN cord-309161-ceahghs1 189 27 profile profile NN cord-309161-ceahghs1 189 28 with with IN cord-309161-ceahghs1 189 29 a a DT cord-309161-ceahghs1 189 30 strong strong JJ cord-309161-ceahghs1 189 31 peak peak NN cord-309161-ceahghs1 189 32 and and CC cord-309161-ceahghs1 189 33 faster fast JJR cord-309161-ceahghs1 189 34 recovery recovery NN cord-309161-ceahghs1 190 1 ( ( -LRB- cord-309161-ceahghs1 190 2 Daubenmier Daubenmier NNP cord-309161-ceahghs1 190 3 et et NNP cord-309161-ceahghs1 190 4 al al NNP cord-309161-ceahghs1 190 5 . . . cord-309161-ceahghs1 191 1 , , , cord-309161-ceahghs1 191 2 2019 2019 CD cord-309161-ceahghs1 191 3 ; ; : cord-309161-ceahghs1 191 4 Lindsay Lindsay NNP cord-309161-ceahghs1 191 5 et et NNP cord-309161-ceahghs1 191 6 al al NNP cord-309161-ceahghs1 191 7 . . NNP cord-309161-ceahghs1 191 8 , , , cord-309161-ceahghs1 191 9 2018 2018 CD cord-309161-ceahghs1 191 10 ) ) -RRB- cord-309161-ceahghs1 192 1 Health health NN cord-309161-ceahghs1 192 2 behaviors behavior NNS cord-309161-ceahghs1 192 3 regulate regulate VBP cord-309161-ceahghs1 192 4 healthspan healthspan NNP cord-309161-ceahghs1 192 5 . . . cord-309161-ceahghs1 193 1 The the DT cord-309161-ceahghs1 193 2 social social JJ cord-309161-ceahghs1 193 3 hallmarks hallmark NNS cord-309161-ceahghs1 193 4 of of IN cord-309161-ceahghs1 193 5 aging age VBG cord-309161-ceahghs1 193 6 shape shape NN cord-309161-ceahghs1 193 7 health health NN cord-309161-ceahghs1 193 8 behaviors behavior NNS cord-309161-ceahghs1 193 9 from from IN cord-309161-ceahghs1 193 10 an an DT cord-309161-ceahghs1 193 11 early early JJ cord-309161-ceahghs1 193 12 age age NN cord-309161-ceahghs1 193 13 , , , cord-309161-ceahghs1 193 14 which which WDT cord-309161-ceahghs1 193 15 track track VBP cord-309161-ceahghs1 193 16 throughout throughout IN cord-309161-ceahghs1 193 17 life life NN cord-309161-ceahghs1 193 18 . . . cord-309161-ceahghs1 194 1 Adverse adverse JJ cord-309161-ceahghs1 194 2 health health NN cord-309161-ceahghs1 194 3 behaviors behavior NNS cord-309161-ceahghs1 194 4 , , , cord-309161-ceahghs1 194 5 such such JJ cord-309161-ceahghs1 194 6 as as IN cord-309161-ceahghs1 194 7 diet diet NN cord-309161-ceahghs1 194 8 , , , cord-309161-ceahghs1 194 9 physical physical JJ cord-309161-ceahghs1 194 10 activity activity NN cord-309161-ceahghs1 194 11 , , , cord-309161-ceahghs1 194 12 sleep sleep NN cord-309161-ceahghs1 194 13 , , , cord-309161-ceahghs1 194 14 and and CC cord-309161-ceahghs1 194 15 smoking smoking NN cord-309161-ceahghs1 194 16 are be VBP cord-309161-ceahghs1 194 17 shaped shape VBN cord-309161-ceahghs1 194 18 by by IN cord-309161-ceahghs1 194 19 social social JJ cord-309161-ceahghs1 194 20 stress stress NN cord-309161-ceahghs1 194 21 . . . cord-309161-ceahghs1 195 1 Chronic chronic JJ cord-309161-ceahghs1 195 2 stress stress NN cord-309161-ceahghs1 195 3 both both DT cord-309161-ceahghs1 195 4 biologically biologically RB cord-309161-ceahghs1 195 5 drives drive VBZ cord-309161-ceahghs1 195 6 toxic toxic JJ cord-309161-ceahghs1 195 7 nutrition nutrition NN cord-309161-ceahghs1 195 8 choices choice NNS cord-309161-ceahghs1 195 9 ( ( -LRB- cord-309161-ceahghs1 195 10 sugar sugar NN cord-309161-ceahghs1 195 11 , , , cord-309161-ceahghs1 195 12 fast fast JJ cord-309161-ceahghs1 195 13 food food NN cord-309161-ceahghs1 195 14 ) ) -RRB- cord-309161-ceahghs1 195 15 , , , cord-309161-ceahghs1 195 16 impairs impair VBZ cord-309161-ceahghs1 195 17 sleep sleep NN cord-309161-ceahghs1 195 18 , , , cord-309161-ceahghs1 195 19 and and CC cord-309161-ceahghs1 195 20 promotes promote VBZ cord-309161-ceahghs1 195 21 addictions addiction NNS cord-309161-ceahghs1 195 22 , , , cord-309161-ceahghs1 195 23 an an DT cord-309161-ceahghs1 195 24 indirect indirect JJ cord-309161-ceahghs1 195 25 pathway pathway NN cord-309161-ceahghs1 195 26 in in IN cord-309161-ceahghs1 195 27 stress stress NN cord-309161-ceahghs1 195 28 - - HYPH cord-309161-ceahghs1 195 29 acceleration acceleration NN cord-309161-ceahghs1 195 30 of of IN cord-309161-ceahghs1 195 31 aging age VBG cord-309161-ceahghs1 195 32 . . . cord-309161-ceahghs1 196 1 The the DT cord-309161-ceahghs1 196 2 converse converse NN cord-309161-ceahghs1 196 3 is be VBZ cord-309161-ceahghs1 196 4 also also RB cord-309161-ceahghs1 196 5 true true JJ cord-309161-ceahghs1 196 6 , , , cord-309161-ceahghs1 196 7 health health NN cord-309161-ceahghs1 196 8 behaviors behavior NNS cord-309161-ceahghs1 196 9 lead lead VBP cord-309161-ceahghs1 196 10 to to IN cord-309161-ceahghs1 196 11 stress stress NN cord-309161-ceahghs1 196 12 - - HYPH cord-309161-ceahghs1 196 13 slowing slowing NN cord-309161-ceahghs1 196 14 of of IN cord-309161-ceahghs1 196 15 aging age VBG cord-309161-ceahghs1 196 16 . . . cord-309161-ceahghs1 197 1 Seventh seventh JJ cord-309161-ceahghs1 197 2 day day NN cord-309161-ceahghs1 197 3 Adventist Adventist NNP cord-309161-ceahghs1 197 4 who who WP cord-309161-ceahghs1 197 5 practice practice VBP cord-309161-ceahghs1 197 6 lifelong lifelong JJ cord-309161-ceahghs1 197 7 positive positive JJ cord-309161-ceahghs1 197 8 health health NN cord-309161-ceahghs1 197 9 behaviors behavior NNS cord-309161-ceahghs1 197 10 , , , cord-309161-ceahghs1 197 11 and and CC cord-309161-ceahghs1 197 12 lack lack VBP cord-309161-ceahghs1 197 13 the the DT cord-309161-ceahghs1 197 14 adverse adverse JJ cord-309161-ceahghs1 197 15 behaviors behavior NNS cord-309161-ceahghs1 197 16 of of IN cord-309161-ceahghs1 197 17 substance substance NN cord-309161-ceahghs1 197 18 use use NN cord-309161-ceahghs1 197 19 , , , cord-309161-ceahghs1 197 20 tend tend VBP cord-309161-ceahghs1 197 21 to to TO cord-309161-ceahghs1 197 22 have have VB cord-309161-ceahghs1 197 23 optimal optimal JJ cord-309161-ceahghs1 197 24 longevity longevity NN cord-309161-ceahghs1 197 25 , , , cord-309161-ceahghs1 197 26 living live VBG cord-309161-ceahghs1 197 27 at at RB cord-309161-ceahghs1 197 28 least least RBS cord-309161-ceahghs1 197 29 four four CD cord-309161-ceahghs1 197 30 years year NNS cord-309161-ceahghs1 197 31 longer long RBR cord-309161-ceahghs1 197 32 than than IN cord-309161-ceahghs1 197 33 the the DT cord-309161-ceahghs1 197 34 average average JJ cord-309161-ceahghs1 197 35 US US NNP cord-309161-ceahghs1 197 36 life life NN cord-309161-ceahghs1 197 37 expectancy expectancy NN cord-309161-ceahghs1 197 38 and and CC cord-309161-ceahghs1 197 39 thus thus RB cord-309161-ceahghs1 197 40 being be VBG cord-309161-ceahghs1 197 41 the the DT cord-309161-ceahghs1 197 42 only only JJ cord-309161-ceahghs1 197 43 blue blue JJ cord-309161-ceahghs1 197 44 zone zone NN cord-309161-ceahghs1 197 45 in in IN cord-309161-ceahghs1 197 46 the the DT cord-309161-ceahghs1 197 47 US US NNP cord-309161-ceahghs1 197 48 ( ( -LRB- cord-309161-ceahghs1 197 49 Fraser Fraser NNP cord-309161-ceahghs1 197 50 & & CC cord-309161-ceahghs1 197 51 Shavlik Shavlik NNP cord-309161-ceahghs1 197 52 , , , cord-309161-ceahghs1 197 53 2001 2001 CD cord-309161-ceahghs1 197 54 ) ) -RRB- cord-309161-ceahghs1 197 55 . . . cord-309161-ceahghs1 198 1 Exercise exercise NN cord-309161-ceahghs1 198 2 is be VBZ cord-309161-ceahghs1 198 3 the the DT cord-309161-ceahghs1 198 4 prototypical prototypical JJ cord-309161-ceahghs1 198 5 hormetic hormetic JJ cord-309161-ceahghs1 198 6 intervention intervention NN cord-309161-ceahghs1 198 7 . . . cord-309161-ceahghs1 199 1 It -PRON- PRP cord-309161-ceahghs1 199 2 increases increase VBZ cord-309161-ceahghs1 199 3 the the DT cord-309161-ceahghs1 199 4 odds odd NNS cord-309161-ceahghs1 199 5 of of IN cord-309161-ceahghs1 199 6 healthy healthy JJ cord-309161-ceahghs1 199 7 aging age VBG cord-309161-ceahghs1 199 8 by by IN cord-309161-ceahghs1 199 9 39 39 CD cord-309161-ceahghs1 199 10 % % NN cord-309161-ceahghs1 200 1 ( ( -LRB- cord-309161-ceahghs1 200 2 Daskalopoulou Daskalopoulou NNP cord-309161-ceahghs1 200 3 et et NNP cord-309161-ceahghs1 200 4 al al NNP cord-309161-ceahghs1 200 5 . . NNP cord-309161-ceahghs1 200 6 , , , cord-309161-ceahghs1 200 7 2017 2017 CD cord-309161-ceahghs1 200 8 ) ) -RRB- cord-309161-ceahghs1 200 9 . . . cord-309161-ceahghs1 201 1 The the DT cord-309161-ceahghs1 201 2 mechanisms mechanism NNS cord-309161-ceahghs1 201 3 at at IN cord-309161-ceahghs1 201 4 the the DT cord-309161-ceahghs1 201 5 cellular cellular JJ cord-309161-ceahghs1 201 6 level level NN cord-309161-ceahghs1 201 7 are be VBP cord-309161-ceahghs1 201 8 becoming become VBG cord-309161-ceahghs1 201 9 well well RB cord-309161-ceahghs1 201 10 explicated explicate VBN cord-309161-ceahghs1 201 11 , , , cord-309161-ceahghs1 201 12 as as IN cord-309161-ceahghs1 201 13 it -PRON- PRP cord-309161-ceahghs1 201 14 can can MD cord-309161-ceahghs1 201 15 enhance enhance VB cord-309161-ceahghs1 201 16 mitochondrial mitochondrial JJ cord-309161-ceahghs1 201 17 health health NN cord-309161-ceahghs1 201 18 , , , cord-309161-ceahghs1 201 19 telomere telomere NN cord-309161-ceahghs1 201 20 biology biology NN cord-309161-ceahghs1 201 21 glucose glucose NN cord-309161-ceahghs1 201 22 , , , cord-309161-ceahghs1 201 23 V02 V02 NNP cord-309161-ceahghs1 201 24 max max NNP cord-309161-ceahghs1 201 25 , , , cord-309161-ceahghs1 201 26 oxidative oxidative JJ cord-309161-ceahghs1 201 27 stress stress NN cord-309161-ceahghs1 201 28 , , , cord-309161-ceahghs1 201 29 NO no NN cord-309161-ceahghs1 201 30 ) ) -RRB- cord-309161-ceahghs1 201 31 and and CC cord-309161-ceahghs1 201 32 upregulation upregulation NN cord-309161-ceahghs1 201 33 stress stress NN cord-309161-ceahghs1 201 34 resistance resistance NN cord-309161-ceahghs1 201 35 pathways pathway NNS cord-309161-ceahghs1 201 36 , , , cord-309161-ceahghs1 201 37 such such JJ cord-309161-ceahghs1 201 38 as as IN cord-309161-ceahghs1 201 39 autophagy autophagy NN cord-309161-ceahghs1 201 40 , , , cord-309161-ceahghs1 201 41 and and CC cord-309161-ceahghs1 201 42 _SP cord-309161-ceahghs1 201 43 Creating create VBG cord-309161-ceahghs1 201 44 the the DT cord-309161-ceahghs1 201 45 opportunity opportunity NN cord-309161-ceahghs1 201 46 for for IN cord-309161-ceahghs1 201 47 a a DT cord-309161-ceahghs1 201 48 long long JJ cord-309161-ceahghs1 201 49 healthspan healthspan NN cord-309161-ceahghs1 201 50 for for IN cord-309161-ceahghs1 201 51 all all DT cord-309161-ceahghs1 201 52 ( ( -LRB- cord-309161-ceahghs1 201 53 health health NN cord-309161-ceahghs1 201 54 equity equity NN cord-309161-ceahghs1 201 55 ) ) -RRB- cord-309161-ceahghs1 201 56 requires require VBZ cord-309161-ceahghs1 201 57 improving improve VBG cord-309161-ceahghs1 201 58 economic economic JJ cord-309161-ceahghs1 201 59 and and CC cord-309161-ceahghs1 201 60 social social JJ cord-309161-ceahghs1 201 61 factors factor NNS cord-309161-ceahghs1 201 62 . . . cord-309161-ceahghs1 202 1 Social social JJ cord-309161-ceahghs1 202 2 factors factor NNS cord-309161-ceahghs1 202 3 are be VBP cord-309161-ceahghs1 202 4 intrinsic intrinsic JJ cord-309161-ceahghs1 202 5 to to IN cord-309161-ceahghs1 202 6 aging age VBG cord-309161-ceahghs1 202 7 , , , cord-309161-ceahghs1 202 8 our -PRON- PRP$ cord-309161-ceahghs1 202 9 rate rate NN cord-309161-ceahghs1 202 10 of of IN cord-309161-ceahghs1 202 11 aging age VBG cord-309161-ceahghs1 202 12 depends depend VBZ cord-309161-ceahghs1 202 13 on on IN cord-309161-ceahghs1 202 14 our -PRON- PRP$ cord-309161-ceahghs1 202 15 social social JJ cord-309161-ceahghs1 202 16 context context NN cord-309161-ceahghs1 202 17 and and CC cord-309161-ceahghs1 202 18 conditions condition NNS cord-309161-ceahghs1 202 19 . . . cord-309161-ceahghs1 203 1 Material material NN cord-309161-ceahghs1 203 2 deprivation deprivation NN cord-309161-ceahghs1 203 3 and and CC cord-309161-ceahghs1 203 4 poor poor JJ cord-309161-ceahghs1 203 5 neighborhood neighborhood NN cord-309161-ceahghs1 203 6 quality quality NN cord-309161-ceahghs1 203 7 confer confer VB cord-309161-ceahghs1 203 8 psychological psychological JJ cord-309161-ceahghs1 203 9 stress stress NN cord-309161-ceahghs1 203 10 and and CC cord-309161-ceahghs1 203 11 risk risk NN cord-309161-ceahghs1 203 12 of of IN cord-309161-ceahghs1 203 13 poor poor JJ cord-309161-ceahghs1 203 14 mental mental JJ cord-309161-ceahghs1 203 15 and and CC cord-309161-ceahghs1 203 16 physiological physiological JJ cord-309161-ceahghs1 203 17 health health NN cord-309161-ceahghs1 204 1 ( ( -LRB- cord-309161-ceahghs1 204 2 Brisson Brisson NNP cord-309161-ceahghs1 204 3 et et NNP cord-309161-ceahghs1 204 4 al al NNP cord-309161-ceahghs1 204 5 . . NNP cord-309161-ceahghs1 204 6 , , , cord-309161-ceahghs1 204 7 2020 2020 CD cord-309161-ceahghs1 204 8 ) ) -RRB- cord-309161-ceahghs1 204 9 . . . cord-309161-ceahghs1 205 1 For for IN cord-309161-ceahghs1 205 2 example example NN cord-309161-ceahghs1 205 3 , , , cord-309161-ceahghs1 205 4 food food NN cord-309161-ceahghs1 205 5 insecurity insecurity NN cord-309161-ceahghs1 205 6 is be VBZ cord-309161-ceahghs1 205 7 associated associate VBN cord-309161-ceahghs1 205 8 with with IN cord-309161-ceahghs1 205 9 over over IN cord-309161-ceahghs1 205 10 two two CD cord-309161-ceahghs1 205 11 fold fold JJ cord-309161-ceahghs1 205 12 risk risk NN cord-309161-ceahghs1 205 13 of of IN cord-309161-ceahghs1 205 14 clinical clinical JJ cord-309161-ceahghs1 205 15 anxiety anxiety NN cord-309161-ceahghs1 205 16 or or CC cord-309161-ceahghs1 205 17 depression depression NN cord-309161-ceahghs1 205 18 in in IN cord-309161-ceahghs1 205 19 adults adult NNS cord-309161-ceahghs1 205 20 , , , cord-309161-ceahghs1 205 21 and and CC cord-309161-ceahghs1 205 22 confers confer VBZ cord-309161-ceahghs1 205 23 even even RB cord-309161-ceahghs1 205 24 higher high JJR cord-309161-ceahghs1 205 25 risk risk NN cord-309161-ceahghs1 205 26 in in IN cord-309161-ceahghs1 205 27 college college NN cord-309161-ceahghs1 205 28 students student NNS cord-309161-ceahghs1 205 29 ( ( -LRB- cord-309161-ceahghs1 205 30 Arenas Arenas NNPS cord-309161-ceahghs1 205 31 et et NNP cord-309161-ceahghs1 205 32 al al NNP cord-309161-ceahghs1 205 33 . . NNP cord-309161-ceahghs1 205 34 , , , cord-309161-ceahghs1 205 35 2019 2019 CD cord-309161-ceahghs1 205 36 ; ; : cord-309161-ceahghs1 205 37 Leung Leung NNP cord-309161-ceahghs1 205 38 et et NNP cord-309161-ceahghs1 205 39 al al NNP cord-309161-ceahghs1 205 40 . . NNP cord-309161-ceahghs1 205 41 , , , cord-309161-ceahghs1 205 42 2020 2020 CD cord-309161-ceahghs1 205 43 ) ) -RRB- cord-309161-ceahghs1 205 44 . . . cord-309161-ceahghs1 206 1 We -PRON- PRP cord-309161-ceahghs1 206 2 now now RB cord-309161-ceahghs1 206 3 have have VBP cord-309161-ceahghs1 206 4 a a DT cord-309161-ceahghs1 206 5 better well JJR cord-309161-ceahghs1 206 6 understanding understanding NN cord-309161-ceahghs1 206 7 of of IN cord-309161-ceahghs1 206 8 how how WRB cord-309161-ceahghs1 206 9 social social JJ cord-309161-ceahghs1 206 10 threats threat NNS cord-309161-ceahghs1 206 11 lead lead VBP cord-309161-ceahghs1 206 12 to to IN cord-309161-ceahghs1 206 13 toxic toxic JJ cord-309161-ceahghs1 206 14 stress stress NN cord-309161-ceahghs1 206 15 . . . cord-309161-ceahghs1 207 1 The the DT cord-309161-ceahghs1 207 2 primary primary JJ cord-309161-ceahghs1 207 3 motivational motivational JJ cord-309161-ceahghs1 207 4 forces force NNS cord-309161-ceahghs1 207 5 shaping shape VBG cord-309161-ceahghs1 207 6 human human JJ cord-309161-ceahghs1 207 7 behavior behavior NN cord-309161-ceahghs1 207 8 are be VBP cord-309161-ceahghs1 207 9 seeking seek VBG cord-309161-ceahghs1 207 10 safety safety NN cord-309161-ceahghs1 207 11 and and CC cord-309161-ceahghs1 207 12 connection connection NN cord-309161-ceahghs1 207 13 with with IN cord-309161-ceahghs1 207 14 others other NNS cord-309161-ceahghs1 207 15 , , , cord-309161-ceahghs1 207 16 and and CC cord-309161-ceahghs1 207 17 avoiding avoid VBG cord-309161-ceahghs1 207 18 danger danger NN cord-309161-ceahghs1 207 19 and and CC cord-309161-ceahghs1 207 20 anxiety anxiety NN cord-309161-ceahghs1 207 21 . . . cord-309161-ceahghs1 208 1 Our -PRON- PRP$ cord-309161-ceahghs1 208 2 mind mind NN cord-309161-ceahghs1 208 3 is be VBZ cord-309161-ceahghs1 208 4 constantly constantly RB cord-309161-ceahghs1 208 5 seeking seek VBG cord-309161-ceahghs1 208 6 cues cue NNS cord-309161-ceahghs1 208 7 for for IN cord-309161-ceahghs1 208 8 safety safety NN cord-309161-ceahghs1 208 9 or or CC cord-309161-ceahghs1 208 10 danger danger NN cord-309161-ceahghs1 208 11 , , , cord-309161-ceahghs1 208 12 even even RB cord-309161-ceahghs1 208 13 when when WRB cord-309161-ceahghs1 208 14 we -PRON- PRP cord-309161-ceahghs1 208 15 are be VBP cord-309161-ceahghs1 208 16 not not RB cord-309161-ceahghs1 208 17 aware aware JJ cord-309161-ceahghs1 208 18 of of IN cord-309161-ceahghs1 208 19 this this DT cord-309161-ceahghs1 208 20 , , , cord-309161-ceahghs1 208 21 and and CC cord-309161-ceahghs1 208 22 these these DT cord-309161-ceahghs1 208 23 social social JJ cord-309161-ceahghs1 208 24 signals signal NNS cord-309161-ceahghs1 208 25 are be VBP cord-309161-ceahghs1 208 26 transduced transduce VBN cord-309161-ceahghs1 208 27 to to IN cord-309161-ceahghs1 208 28 biological biological JJ cord-309161-ceahghs1 208 29 signals signal NNS cord-309161-ceahghs1 208 30 , , , cord-309161-ceahghs1 208 31 including include VBG cord-309161-ceahghs1 208 32 patterns pattern NNS cord-309161-ceahghs1 208 33 of of IN cord-309161-ceahghs1 208 34 autonomic autonomic JJ cord-309161-ceahghs1 208 35 activity activity NN cord-309161-ceahghs1 208 36 and and CC cord-309161-ceahghs1 208 37 gene gene NN cord-309161-ceahghs1 208 38 expression expression NN cord-309161-ceahghs1 208 39 that that WDT cord-309161-ceahghs1 208 40 are be VBP cord-309161-ceahghs1 208 41 linked link VBN cord-309161-ceahghs1 208 42 to to IN cord-309161-ceahghs1 208 43 inflammation inflammation NN cord-309161-ceahghs1 208 44 . . . cord-309161-ceahghs1 209 1 It -PRON- PRP cord-309161-ceahghs1 209 2 is be VBZ cord-309161-ceahghs1 209 3 thought think VBN cord-309161-ceahghs1 209 4 that that IN cord-309161-ceahghs1 209 5 exposure exposure NN cord-309161-ceahghs1 209 6 to to IN cord-309161-ceahghs1 209 7 or or CC cord-309161-ceahghs1 209 8 perception perception NN cord-309161-ceahghs1 209 9 of of IN cord-309161-ceahghs1 209 10 frequent frequent JJ cord-309161-ceahghs1 209 11 social social JJ cord-309161-ceahghs1 209 12 threats threat NNS cord-309161-ceahghs1 209 13 ( ( -LRB- cord-309161-ceahghs1 209 14 such such JJ cord-309161-ceahghs1 209 15 as as IN cord-309161-ceahghs1 209 16 social social JJ cord-309161-ceahghs1 209 17 rejection rejection NN cord-309161-ceahghs1 209 18 , , , cord-309161-ceahghs1 209 19 discrimination discrimination NN cord-309161-ceahghs1 209 20 , , , cord-309161-ceahghs1 209 21 violence violence NN cord-309161-ceahghs1 209 22 , , , cord-309161-ceahghs1 209 23 and and CC cord-309161-ceahghs1 209 24 lack lack NN cord-309161-ceahghs1 209 25 of of IN cord-309161-ceahghs1 209 26 safety safety NN cord-309161-ceahghs1 209 27 ) ) -RRB- cord-309161-ceahghs1 209 28 creates create VBZ cord-309161-ceahghs1 209 29 higher high JJR cord-309161-ceahghs1 209 30 chronic chronic JJ cord-309161-ceahghs1 209 31 systemic systemic JJ cord-309161-ceahghs1 209 32 inflammation inflammation NN cord-309161-ceahghs1 209 33 and and CC cord-309161-ceahghs1 209 34 sympathetic sympathetic JJ cord-309161-ceahghs1 209 35 arousal arousal NN cord-309161-ceahghs1 209 36 , , , cord-309161-ceahghs1 209 37 even even RB cord-309161-ceahghs1 209 38 while while IN cord-309161-ceahghs1 209 39 sleeping sleep VBG cord-309161-ceahghs1 209 40 , , , cord-309161-ceahghs1 209 41 and and CC cord-309161-ceahghs1 209 42 greater great JJR cord-309161-ceahghs1 209 43 risk risk NN cord-309161-ceahghs1 209 44 of of IN cord-309161-ceahghs1 209 45 affective affective JJ cord-309161-ceahghs1 209 46 disorders disorder NNS cord-309161-ceahghs1 209 47 ( ( -LRB- cord-309161-ceahghs1 209 48 Brosschot Brosschot NNP cord-309161-ceahghs1 209 49 et et NNP cord-309161-ceahghs1 209 50 al al NNP cord-309161-ceahghs1 209 51 . . NNP cord-309161-ceahghs1 209 52 , , , cord-309161-ceahghs1 209 53 2017 2017 CD cord-309161-ceahghs1 209 54 ; ; : cord-309161-ceahghs1 209 55 O'Donovan O'Donovan NNP cord-309161-ceahghs1 209 56 et et NNP cord-309161-ceahghs1 209 57 al al NNP cord-309161-ceahghs1 209 58 . . NNP cord-309161-ceahghs1 209 59 , , , cord-309161-ceahghs1 209 60 2013 2013 CD cord-309161-ceahghs1 209 61 ; ; : cord-309161-ceahghs1 209 62 Slavich Slavich NNP cord-309161-ceahghs1 209 63 , , , cord-309161-ceahghs1 209 64 2020 2020 CD cord-309161-ceahghs1 209 65 ; ; : cord-309161-ceahghs1 209 66 Slavich Slavich NNP cord-309161-ceahghs1 209 67 et et NNP cord-309161-ceahghs1 209 68 al al NNP cord-309161-ceahghs1 209 69 . . NNP cord-309161-ceahghs1 209 70 , , , cord-309161-ceahghs1 209 71 2010 2010 CD cord-309161-ceahghs1 209 72 ) ) -RRB- cord-309161-ceahghs1 209 73 . . . cord-309161-ceahghs1 210 1 Conversely conversely RB cord-309161-ceahghs1 210 2 , , , cord-309161-ceahghs1 210 3 social social JJ cord-309161-ceahghs1 210 4 support support NN cord-309161-ceahghs1 210 5 , , , cord-309161-ceahghs1 210 6 and and CC cord-309161-ceahghs1 210 7 social social JJ cord-309161-ceahghs1 210 8 capital capital NN cord-309161-ceahghs1 210 9 including include VBG cord-309161-ceahghs1 210 10 perceived perceive VBN cord-309161-ceahghs1 210 11 safety safety NN cord-309161-ceahghs1 210 12 in in IN cord-309161-ceahghs1 210 13 neighborhoods neighborhood NNS cord-309161-ceahghs1 210 14 , , , cord-309161-ceahghs1 210 15 may may MD cord-309161-ceahghs1 210 16 be be VB cord-309161-ceahghs1 210 17 stress stress NN cord-309161-ceahghs1 210 18 buffering buffering NN cord-309161-ceahghs1 210 19 , , , cord-309161-ceahghs1 210 20 and and CC cord-309161-ceahghs1 210 21 are be VBP cord-309161-ceahghs1 210 22 often often RB cord-309161-ceahghs1 210 23 associated associate VBN cord-309161-ceahghs1 210 24 with with IN cord-309161-ceahghs1 210 25 less less JJR cord-309161-ceahghs1 210 26 inflammation inflammation NN cord-309161-ceahghs1 210 27 and and CC cord-309161-ceahghs1 210 28 longer long JJR cord-309161-ceahghs1 210 29 telomeres telomere NNS cord-309161-ceahghs1 210 30 ( ( -LRB- cord-309161-ceahghs1 210 31 Brown Brown NNP cord-309161-ceahghs1 210 32 et et NNP cord-309161-ceahghs1 210 33 al al NNP cord-309161-ceahghs1 210 34 . . NNP cord-309161-ceahghs1 210 35 , , , cord-309161-ceahghs1 210 36 2020 2020 CD cord-309161-ceahghs1 210 37 ; ; : cord-309161-ceahghs1 210 38 Rentscher Rentscher NNP cord-309161-ceahghs1 210 39 et et FW cord-309161-ceahghs1 210 40 al al NNP cord-309161-ceahghs1 210 41 . . . cord-309161-ceahghs1 211 1 , , , cord-309161-ceahghs1 211 2 2020 2020 CD cord-309161-ceahghs1 211 3 ; ; : cord-309161-ceahghs1 211 4 Thames Thames NNP cord-309161-ceahghs1 211 5 et et NNP cord-309161-ceahghs1 211 6 al al NNP cord-309161-ceahghs1 211 7 . . NNP cord-309161-ceahghs1 211 8 , , , cord-309161-ceahghs1 211 9 2019 2019 CD cord-309161-ceahghs1 211 10 ) ) -RRB- cord-309161-ceahghs1 212 1 ( ( -LRB- cord-309161-ceahghs1 212 2 Geronimus Geronimus NNP cord-309161-ceahghs1 212 3 et et NNP cord-309161-ceahghs1 212 4 al al NNP cord-309161-ceahghs1 212 5 . . NNP cord-309161-ceahghs1 212 6 , , , cord-309161-ceahghs1 212 7 2015 2015 CD cord-309161-ceahghs1 212 8 ; ; : cord-309161-ceahghs1 212 9 M. M. NNP cord-309161-ceahghs1 212 10 Park Park NNP cord-309161-ceahghs1 212 11 et et FW cord-309161-ceahghs1 212 12 al al NNP cord-309161-ceahghs1 212 13 . . NNP cord-309161-ceahghs1 212 14 , , , cord-309161-ceahghs1 212 15 2015 2015 CD cord-309161-ceahghs1 212 16 ) ) -RRB- cord-309161-ceahghs1 212 17 . . . cord-309161-ceahghs1 213 1 Social social JJ cord-309161-ceahghs1 213 2 support support NN cord-309161-ceahghs1 213 3 and and CC cord-309161-ceahghs1 213 4 social social JJ cord-309161-ceahghs1 213 5 networks network NNS cord-309161-ceahghs1 213 6 can can MD cord-309161-ceahghs1 213 7 bolster bolster VB cord-309161-ceahghs1 213 8 healthspan healthspan JJ cord-309161-ceahghs1 213 9 interventions intervention NNS cord-309161-ceahghs1 213 10 : : : cord-309161-ceahghs1 214 1 Our -PRON- PRP$ cord-309161-ceahghs1 214 2 stress stress NN cord-309161-ceahghs1 214 3 , , , cord-309161-ceahghs1 214 4 emotional emotional JJ cord-309161-ceahghs1 214 5 and and CC cord-309161-ceahghs1 214 6 physiological physiological JJ cord-309161-ceahghs1 214 7 , , , cord-309161-ceahghs1 214 8 is be VBZ cord-309161-ceahghs1 214 9 contagious contagious JJ cord-309161-ceahghs1 214 10 to to TO cord-309161-ceahghs1 214 11 close close VB cord-309161-ceahghs1 214 12 others other NNS cord-309161-ceahghs1 214 13 ( ( -LRB- cord-309161-ceahghs1 214 14 Carnevali Carnevali NNP cord-309161-ceahghs1 214 15 et et NNP cord-309161-ceahghs1 214 16 al al NNP cord-309161-ceahghs1 214 17 . . NNP cord-309161-ceahghs1 214 18 , , , cord-309161-ceahghs1 214 19 2020 2020 CD cord-309161-ceahghs1 214 20 ; ; . cord-309161-ceahghs1 215 1 Engert Engert NNP cord-309161-ceahghs1 215 2 et et NNP cord-309161-ceahghs1 215 3 al al NNP cord-309161-ceahghs1 215 4 . . NNP cord-309161-ceahghs1 215 5 , , , cord-309161-ceahghs1 215 6 2019 2019 CD cord-309161-ceahghs1 215 7 ) ) -RRB- cord-309161-ceahghs1 215 8 , , , cord-309161-ceahghs1 215 9 and and CC cord-309161-ceahghs1 215 10 conversely conversely RB cord-309161-ceahghs1 215 11 positive positive JJ cord-309161-ceahghs1 215 12 emotion emotion NN cord-309161-ceahghs1 215 13 and and CC cord-309161-ceahghs1 215 14 positive positive JJ cord-309161-ceahghs1 215 15 health health NN cord-309161-ceahghs1 215 16 behaviors behavior NNS cord-309161-ceahghs1 215 17 are be VBP cord-309161-ceahghs1 215 18 also also RB cord-309161-ceahghs1 215 19 socially socially RB cord-309161-ceahghs1 215 20 influenced influence VBN cord-309161-ceahghs1 215 21 ( ( -LRB- cord-309161-ceahghs1 215 22 Christakis Christakis NNP cord-309161-ceahghs1 215 23 & & CC cord-309161-ceahghs1 215 24 Fowler Fowler NNP cord-309161-ceahghs1 215 25 , , , cord-309161-ceahghs1 215 26 2013 2013 CD cord-309161-ceahghs1 215 27 ; ; : cord-309161-ceahghs1 215 28 Kim Kim NNP cord-309161-ceahghs1 215 29 et et NNP cord-309161-ceahghs1 215 30 al al NNP cord-309161-ceahghs1 215 31 . . NNP cord-309161-ceahghs1 215 32 , , , cord-309161-ceahghs1 215 33 2015 2015 CD cord-309161-ceahghs1 215 34 ) ) -RRB- cord-309161-ceahghs1 215 35 . . . cord-309161-ceahghs1 216 1 The the DT cord-309161-ceahghs1 216 2 geroscience geroscience NN cord-309161-ceahghs1 216 3 interventions intervention NNS cord-309161-ceahghs1 216 4 that that WDT cord-309161-ceahghs1 216 5 may may MD cord-309161-ceahghs1 216 6 work work VB cord-309161-ceahghs1 216 7 in in IN cord-309161-ceahghs1 216 8 mice mouse NNS cord-309161-ceahghs1 216 9 will will MD cord-309161-ceahghs1 216 10 not not RB cord-309161-ceahghs1 216 11 be be VB cord-309161-ceahghs1 216 12 useful useful JJ cord-309161-ceahghs1 216 13 if if IN cord-309161-ceahghs1 216 14 they -PRON- PRP cord-309161-ceahghs1 216 15 can can MD cord-309161-ceahghs1 216 16 not not RB cord-309161-ceahghs1 216 17 be be VB cord-309161-ceahghs1 216 18 translated translate VBN cord-309161-ceahghs1 216 19 well well RB cord-309161-ceahghs1 216 20 to to IN cord-309161-ceahghs1 216 21 humans human NNS cord-309161-ceahghs1 216 22 , , , cord-309161-ceahghs1 216 23 taking take VBG cord-309161-ceahghs1 216 24 into into IN cord-309161-ceahghs1 216 25 account account NN cord-309161-ceahghs1 216 26 our -PRON- PRP$ cord-309161-ceahghs1 216 27 need need NN cord-309161-ceahghs1 216 28 for for IN cord-309161-ceahghs1 216 29 support support NN cord-309161-ceahghs1 216 30 and and CC cord-309161-ceahghs1 216 31 the the DT cord-309161-ceahghs1 216 32 significant significant JJ cord-309161-ceahghs1 216 33 challenges challenge NNS cord-309161-ceahghs1 216 34 we -PRON- PRP cord-309161-ceahghs1 216 35 have have VBP cord-309161-ceahghs1 216 36 with with IN cord-309161-ceahghs1 216 37 adherence adherence NN cord-309161-ceahghs1 216 38 to to TO cord-309161-ceahghs1 216 39 exercise exercise VB cord-309161-ceahghs1 216 40 and and CC cord-309161-ceahghs1 216 41 other other JJ cord-309161-ceahghs1 216 42 lifestyle lifestyle NN cord-309161-ceahghs1 216 43 changes change NNS cord-309161-ceahghs1 216 44 . . . cord-309161-ceahghs1 217 1 Poor poor JJ cord-309161-ceahghs1 217 2 behaviors behavior NNS cord-309161-ceahghs1 217 3 can can MD cord-309161-ceahghs1 217 4 override override VB cord-309161-ceahghs1 217 5 effects effect NNS cord-309161-ceahghs1 217 6 of of IN cord-309161-ceahghs1 217 7 protective protective JJ cord-309161-ceahghs1 217 8 pharmaceuticals pharmaceutical NNS cord-309161-ceahghs1 217 9 . . . cord-309161-ceahghs1 218 1 A a DT cord-309161-ceahghs1 218 2 common common JJ cord-309161-ceahghs1 218 3 example example NN cord-309161-ceahghs1 218 4 of of IN cord-309161-ceahghs1 218 5 this this DT cord-309161-ceahghs1 218 6 is be VBZ cord-309161-ceahghs1 218 7 that that IN cord-309161-ceahghs1 218 8 people people NNS cord-309161-ceahghs1 218 9 still still RB cord-309161-ceahghs1 218 10 develop develop VBP cord-309161-ceahghs1 218 11 diabetes diabete NNS cord-309161-ceahghs1 218 12 while while IN cord-309161-ceahghs1 218 13 taking take VBG cord-309161-ceahghs1 218 14 metformin metformin NNP cord-309161-ceahghs1 218 15 due due IN cord-309161-ceahghs1 218 16 to to IN cord-309161-ceahghs1 218 17 overeating overeat VBG cord-309161-ceahghs1 218 18 a a DT cord-309161-ceahghs1 218 19 western western JJ cord-309161-ceahghs1 218 20 junk junk NN cord-309161-ceahghs1 218 21 food food NN cord-309161-ceahghs1 218 22 diet diet NN cord-309161-ceahghs1 218 23 . . . cord-309161-ceahghs1 219 1 Improving improve VBG cord-309161-ceahghs1 219 2 health health NN cord-309161-ceahghs1 219 3 behaviors behavior NNS cord-309161-ceahghs1 219 4 can can MD cord-309161-ceahghs1 219 5 best best RB cord-309161-ceahghs1 219 6 be be VB cord-309161-ceahghs1 219 7 prioritized prioritize VBN cord-309161-ceahghs1 219 8 and and CC cord-309161-ceahghs1 219 9 implemented implement VBN cord-309161-ceahghs1 219 10 in in IN cord-309161-ceahghs1 219 11 the the DT cord-309161-ceahghs1 219 12 context context NN cord-309161-ceahghs1 219 13 where where WRB cord-309161-ceahghs1 219 14 basic basic JJ cord-309161-ceahghs1 219 15 social social JJ cord-309161-ceahghs1 219 16 needs need NNS cord-309161-ceahghs1 219 17 are be VBP cord-309161-ceahghs1 219 18 met meet VBN cord-309161-ceahghs1 219 19 . . . cord-309161-ceahghs1 220 1 Creating create VBG cord-309161-ceahghs1 220 2 a a DT cord-309161-ceahghs1 220 3 supportive supportive JJ cord-309161-ceahghs1 220 4 built build VBN cord-309161-ceahghs1 220 5 environment environment NN cord-309161-ceahghs1 220 6 and and CC cord-309161-ceahghs1 220 7 positive positive JJ cord-309161-ceahghs1 220 8 social social JJ cord-309161-ceahghs1 220 9 environment environment NN cord-309161-ceahghs1 220 10 are be VBP cord-309161-ceahghs1 220 11 critical critical JJ cord-309161-ceahghs1 220 12 to to IN cord-309161-ceahghs1 220 13 promoting promote VBG cord-309161-ceahghs1 220 14 long long JJ cord-309161-ceahghs1 220 15 - - HYPH cord-309161-ceahghs1 220 16 term term NN cord-309161-ceahghs1 220 17 behavior behavior NN cord-309161-ceahghs1 220 18 change change NN cord-309161-ceahghs1 220 19 . . . cord-309161-ceahghs1 221 1 The the DT cord-309161-ceahghs1 221 2 science science NN cord-309161-ceahghs1 221 3 of of IN cord-309161-ceahghs1 221 4 behavior behavior NN cord-309161-ceahghs1 221 5 change change NN cord-309161-ceahghs1 221 6 , , , cord-309161-ceahghs1 221 7 including include VBG cord-309161-ceahghs1 221 8 the the DT cord-309161-ceahghs1 221 9 NIH NIH NNP cord-309161-ceahghs1 221 10 initiative initiative NN cord-309161-ceahghs1 221 11 focusing focus VBG cord-309161-ceahghs1 221 12 on on IN cord-309161-ceahghs1 221 13 this this DT cord-309161-ceahghs1 221 14 ( ( -LRB- cord-309161-ceahghs1 221 15 Nielsen Nielsen NNP cord-309161-ceahghs1 221 16 et et NNP cord-309161-ceahghs1 221 17 al al NNP cord-309161-ceahghs1 221 18 . . NNP cord-309161-ceahghs1 221 19 , , , cord-309161-ceahghs1 221 20 2018 2018 CD cord-309161-ceahghs1 221 21 ) ) -RRB- cord-309161-ceahghs1 221 22 , , , cord-309161-ceahghs1 221 23 has have VBZ cord-309161-ceahghs1 221 24 dramatically dramatically RB cord-309161-ceahghs1 221 25 raised raise VBN cord-309161-ceahghs1 221 26 the the DT cord-309161-ceahghs1 221 27 sophistication sophistication NN cord-309161-ceahghs1 221 28 of of IN cord-309161-ceahghs1 221 29 the the DT cord-309161-ceahghs1 221 30 research research NN cord-309161-ceahghs1 221 31 in in IN cord-309161-ceahghs1 221 32 this this DT cord-309161-ceahghs1 221 33 area area NN cord-309161-ceahghs1 221 34 , , , cord-309161-ceahghs1 221 35 using use VBG cord-309161-ceahghs1 221 36 the the DT cord-309161-ceahghs1 221 37 experimental experimental JJ cord-309161-ceahghs1 221 38 medicine medicine NN cord-309161-ceahghs1 221 39 model model NN cord-309161-ceahghs1 221 40 to to TO cord-309161-ceahghs1 221 41 identify identify VB cord-309161-ceahghs1 221 42 and and CC cord-309161-ceahghs1 221 43 manipulate manipulate VB cord-309161-ceahghs1 221 44 the the DT cord-309161-ceahghs1 221 45 behavioral behavioral JJ cord-309161-ceahghs1 221 46 and and CC cord-309161-ceahghs1 221 47 social social JJ cord-309161-ceahghs1 221 48 factors factor NNS cord-309161-ceahghs1 221 49 that that WDT cord-309161-ceahghs1 221 50 facilitate facilitate VBP cord-309161-ceahghs1 221 51 adherence adherence NN cord-309161-ceahghs1 221 52 to to IN cord-309161-ceahghs1 221 53 health health NN cord-309161-ceahghs1 221 54 behaviors behavior NNS cord-309161-ceahghs1 221 55 . . . cord-309161-ceahghs1 222 1 Behavioral behavioral JJ cord-309161-ceahghs1 222 2 or or CC cord-309161-ceahghs1 222 3 health health NN cord-309161-ceahghs1 222 4 Interventions intervention NNS cord-309161-ceahghs1 222 5 that that WDT cord-309161-ceahghs1 222 6 work work VBP cord-309161-ceahghs1 222 7 beyond beyond IN cord-309161-ceahghs1 222 8 the the DT cord-309161-ceahghs1 222 9 individual individual JJ cord-309161-ceahghs1 222 10 level level NN cord-309161-ceahghs1 223 1 , , , cord-309161-ceahghs1 223 2 that that DT cord-309161-ceahghs1 223 3 can can MD cord-309161-ceahghs1 223 4 decrease decrease VB cord-309161-ceahghs1 223 5 loneliness loneliness NN cord-309161-ceahghs1 223 6 and and CC cord-309161-ceahghs1 223 7 improve improve VB cord-309161-ceahghs1 223 8 support support NN cord-309161-ceahghs1 223 9 will will MD cord-309161-ceahghs1 223 10 be be VB cord-309161-ceahghs1 223 11 more more RBR cord-309161-ceahghs1 223 12 successful successful JJ cord-309161-ceahghs1 223 13 . . . cord-309161-ceahghs1 224 1 The the DT cord-309161-ceahghs1 224 2 COVID-19 COVID-19 NNP cord-309161-ceahghs1 224 3 pandemic pandemic NN cord-309161-ceahghs1 224 4 demonstrates demonstrate VBZ cord-309161-ceahghs1 224 5 well well RB cord-309161-ceahghs1 224 6 the the DT cord-309161-ceahghs1 224 7 role role NN cord-309161-ceahghs1 224 8 of of IN cord-309161-ceahghs1 224 9 social social JJ cord-309161-ceahghs1 224 10 factors factor NNS cord-309161-ceahghs1 224 11 in in IN cord-309161-ceahghs1 224 12 resilience resilience NN cord-309161-ceahghs1 224 13 to to IN cord-309161-ceahghs1 224 14 mental mental JJ cord-309161-ceahghs1 224 15 health health NN cord-309161-ceahghs1 224 16 disorders disorder NNS cord-309161-ceahghs1 224 17 and and CC cord-309161-ceahghs1 224 18 infection infection NN cord-309161-ceahghs1 224 19 . . . cord-309161-ceahghs1 225 1 The the DT cord-309161-ceahghs1 225 2 pandemic pandemic NN cord-309161-ceahghs1 225 3 led lead VBD cord-309161-ceahghs1 225 4 to to IN cord-309161-ceahghs1 225 5 dramatic dramatic JJ cord-309161-ceahghs1 225 6 increases increase NNS cord-309161-ceahghs1 225 7 in in IN cord-309161-ceahghs1 225 8 mental mental JJ cord-309161-ceahghs1 225 9 health health NN cord-309161-ceahghs1 225 10 disorders disorder NNS cord-309161-ceahghs1 225 11 in in IN cord-309161-ceahghs1 225 12 the the DT cord-309161-ceahghs1 225 13 US US NNP cord-309161-ceahghs1 225 14 and and CC cord-309161-ceahghs1 225 15 other other JJ cord-309161-ceahghs1 225 16 countries country NNS cord-309161-ceahghs1 225 17 ( ( -LRB- cord-309161-ceahghs1 225 18 Xiong Xiong NNP cord-309161-ceahghs1 225 19 et et NNP cord-309161-ceahghs1 225 20 al al NNP cord-309161-ceahghs1 225 21 . . NNP cord-309161-ceahghs1 225 22 , , , cord-309161-ceahghs1 225 23 2020 2020 CD cord-309161-ceahghs1 225 24 ) ) -RRB- cord-309161-ceahghs1 225 25 but but CC cord-309161-ceahghs1 225 26 this this DT cord-309161-ceahghs1 225 27 was be VBD cord-309161-ceahghs1 225 28 not not RB cord-309161-ceahghs1 225 29 equally equally RB cord-309161-ceahghs1 225 30 distributed distribute VBN cord-309161-ceahghs1 225 31 . . . cord-309161-ceahghs1 226 1 Those those DT cord-309161-ceahghs1 226 2 with with IN cord-309161-ceahghs1 226 3 low low JJ cord-309161-ceahghs1 226 4 education education NN cord-309161-ceahghs1 226 5 , , , cord-309161-ceahghs1 226 6 income income NN cord-309161-ceahghs1 226 7 , , , cord-309161-ceahghs1 226 8 minority minority NN cord-309161-ceahghs1 226 9 status status NN cord-309161-ceahghs1 226 10 , , , cord-309161-ceahghs1 226 11 loneliness loneliness NN cord-309161-ceahghs1 226 12 , , , cord-309161-ceahghs1 226 13 or or CC cord-309161-ceahghs1 226 14 low low JJ cord-309161-ceahghs1 226 15 social social JJ cord-309161-ceahghs1 226 16 support support NN cord-309161-ceahghs1 226 17 have have VBP cord-309161-ceahghs1 226 18 significantly significantly RB cord-309161-ceahghs1 226 19 higher high JJR cord-309161-ceahghs1 226 20 rates rate NNS cord-309161-ceahghs1 226 21 of of IN cord-309161-ceahghs1 226 22 mental mental JJ cord-309161-ceahghs1 226 23 health health NN cord-309161-ceahghs1 226 24 disorders disorder NNS cord-309161-ceahghs1 226 25 from from IN cord-309161-ceahghs1 226 26 pandemic pandemic JJ cord-309161-ceahghs1 226 27 stress stress NN cord-309161-ceahghs1 227 1 ( ( -LRB- cord-309161-ceahghs1 227 2 Arafa Arafa NNP cord-309161-ceahghs1 227 3 et et FW cord-309161-ceahghs1 227 4 al al NNP cord-309161-ceahghs1 227 5 . . NNP cord-309161-ceahghs1 227 6 , , , cord-309161-ceahghs1 227 7 2020 2020 CD cord-309161-ceahghs1 227 8 ; ; : cord-309161-ceahghs1 227 9 Holingue Holingue NNP cord-309161-ceahghs1 227 10 et et NNP cord-309161-ceahghs1 227 11 al al NNP cord-309161-ceahghs1 227 12 . . NNP cord-309161-ceahghs1 227 13 , , , cord-309161-ceahghs1 227 14 2020 2020 CD cord-309161-ceahghs1 228 1 ; ; : cord-309161-ceahghs1 228 2 Palgi Palgi NNP cord-309161-ceahghs1 228 3 et et NNP cord-309161-ceahghs1 228 4 al al NNP cord-309161-ceahghs1 228 5 . . NNP cord-309161-ceahghs1 228 6 , , , cord-309161-ceahghs1 228 7 2020 2020 CD cord-309161-ceahghs1 228 8 ) ) -RRB- cord-309161-ceahghs1 228 9 . . . cord-309161-ceahghs1 229 1 These these DT cord-309161-ceahghs1 229 2 vulnerable vulnerable JJ cord-309161-ceahghs1 229 3 groups group NNS cord-309161-ceahghs1 229 4 also also RB cord-309161-ceahghs1 229 5 tend tend VBP cord-309161-ceahghs1 229 6 to to TO cord-309161-ceahghs1 229 7 have have VB cord-309161-ceahghs1 229 8 higher high JJR cord-309161-ceahghs1 229 9 rates rate NNS cord-309161-ceahghs1 229 10 of of IN cord-309161-ceahghs1 229 11 COVID covid JJ cord-309161-ceahghs1 229 12 severity severity NN cord-309161-ceahghs1 229 13 ( ( -LRB- cord-309161-ceahghs1 229 14 Adhikari Adhikari NNP cord-309161-ceahghs1 229 15 et et NNP cord-309161-ceahghs1 229 16 al al NNP cord-309161-ceahghs1 229 17 . . NNP cord-309161-ceahghs1 229 18 , , , cord-309161-ceahghs1 229 19 2020 2020 CD cord-309161-ceahghs1 229 20 ; ; : cord-309161-ceahghs1 229 21 Webb Webb NNP cord-309161-ceahghs1 229 22 Hooper Hooper NNP cord-309161-ceahghs1 229 23 et et NNP cord-309161-ceahghs1 229 24 al al NNP cord-309161-ceahghs1 229 25 . . NNP cord-309161-ceahghs1 229 26 , , , cord-309161-ceahghs1 229 27 2020 2020 CD cord-309161-ceahghs1 229 28 ) ) -RRB- cord-309161-ceahghs1 229 29 . . . cord-309161-ceahghs1 230 1 Any any DT cord-309161-ceahghs1 230 2 policies policy NNS cord-309161-ceahghs1 230 3 that that WDT cord-309161-ceahghs1 230 4 improve improve VBP cord-309161-ceahghs1 230 5 social social JJ cord-309161-ceahghs1 230 6 equity equity NN cord-309161-ceahghs1 230 7 are be VBP cord-309161-ceahghs1 230 8 also also RB cord-309161-ceahghs1 230 9 ' ' `` cord-309161-ceahghs1 230 10 stress stress NN cord-309161-ceahghs1 230 11 reducing reduce VBG cord-309161-ceahghs1 230 12 ' ' '' cord-309161-ceahghs1 230 13 health health NN cord-309161-ceahghs1 230 14 policies policy NNS cord-309161-ceahghs1 230 15 that that WDT cord-309161-ceahghs1 230 16 may may MD cord-309161-ceahghs1 230 17 contribute contribute VB cord-309161-ceahghs1 230 18 to to IN cord-309161-ceahghs1 230 19 healthspan healthspan NNP cord-309161-ceahghs1 230 20 , , , cord-309161-ceahghs1 230 21 and and CC cord-309161-ceahghs1 230 22 can can MD cord-309161-ceahghs1 230 23 be be VB cord-309161-ceahghs1 230 24 incorporated incorporate VBN cord-309161-ceahghs1 230 25 into into IN cord-309161-ceahghs1 230 26 the the DT cord-309161-ceahghs1 230 27 geroscience geroscience NN cord-309161-ceahghs1 230 28 agenda agenda NN cord-309161-ceahghs1 230 29 . . . cord-309161-ceahghs1 231 1 Geroscience Geroscience NNP cord-309161-ceahghs1 231 2 is be VBZ cord-309161-ceahghs1 231 3 now now RB cord-309161-ceahghs1 231 4 more more RBR cord-309161-ceahghs1 231 5 important important JJ cord-309161-ceahghs1 231 6 than than IN cord-309161-ceahghs1 231 7 ever ever RB cord-309161-ceahghs1 231 8 , , , cord-309161-ceahghs1 231 9 both both DT cord-309161-ceahghs1 231 10 to to IN cord-309161-ceahghs1 231 11 our -PRON- PRP$ cord-309161-ceahghs1 231 12 aging age VBG cord-309161-ceahghs1 231 13 global global JJ cord-309161-ceahghs1 231 14 demography demography NN cord-309161-ceahghs1 231 15 but but CC cord-309161-ceahghs1 231 16 also also RB cord-309161-ceahghs1 231 17 to to IN cord-309161-ceahghs1 231 18 the the DT cord-309161-ceahghs1 231 19 health health NN cord-309161-ceahghs1 231 20 challenges challenge NNS cord-309161-ceahghs1 231 21 we -PRON- PRP cord-309161-ceahghs1 231 22 face face VBP cord-309161-ceahghs1 231 23 going go VBG cord-309161-ceahghs1 231 24 forward forward RB cord-309161-ceahghs1 231 25 . . . cord-309161-ceahghs1 232 1 In in IN cord-309161-ceahghs1 232 2 our -PRON- PRP$ cord-309161-ceahghs1 232 3 new new JJ cord-309161-ceahghs1 232 4 era era NN cord-309161-ceahghs1 232 5 we -PRON- PRP cord-309161-ceahghs1 232 6 have have VBP cord-309161-ceahghs1 232 7 dramatically dramatically RB cord-309161-ceahghs1 232 8 increasing increase VBG cord-309161-ceahghs1 232 9 temperature temperature NN cord-309161-ceahghs1 232 10 extremes extreme NNS cord-309161-ceahghs1 232 11 , , , cord-309161-ceahghs1 232 12 wildfires wildfire NNS cord-309161-ceahghs1 232 13 and and CC cord-309161-ceahghs1 232 14 small small JJ cord-309161-ceahghs1 232 15 particle particle NN cord-309161-ceahghs1 232 16 pollution pollution NN cord-309161-ceahghs1 232 17 , , , cord-309161-ceahghs1 232 18 and and CC cord-309161-ceahghs1 232 19 new new JJ cord-309161-ceahghs1 232 20 zoonotic zoonotic JJ cord-309161-ceahghs1 232 21 viruses virus NNS cord-309161-ceahghs1 232 22 to to TO cord-309161-ceahghs1 232 23 contend contend VB cord-309161-ceahghs1 232 24 with with IN cord-309161-ceahghs1 232 25 intermittently intermittently RB cord-309161-ceahghs1 232 26 . . . cord-309161-ceahghs1 233 1 Thus thus RB cord-309161-ceahghs1 233 2 reducing reduce VBG cord-309161-ceahghs1 233 3 social social JJ cord-309161-ceahghs1 233 4 disparities disparity NNS cord-309161-ceahghs1 233 5 , , , cord-309161-ceahghs1 233 6 improving improve VBG cord-309161-ceahghs1 233 7 stress stress NN cord-309161-ceahghs1 233 8 resilience resilience NN cord-309161-ceahghs1 233 9 and and CC cord-309161-ceahghs1 233 10 bolstering bolster VBG cord-309161-ceahghs1 233 11 immune immune JJ cord-309161-ceahghs1 233 12 function function NN cord-309161-ceahghs1 233 13 have have VBP cord-309161-ceahghs1 233 14 become become VBN cord-309161-ceahghs1 233 15 critical critical JJ cord-309161-ceahghs1 233 16 public public JJ cord-309161-ceahghs1 233 17 health health NN cord-309161-ceahghs1 233 18 goals goal NNS cord-309161-ceahghs1 233 19 . . . cord-309161-ceahghs1 234 1 The the DT cord-309161-ceahghs1 234 2 vulnerability vulnerability NN cord-309161-ceahghs1 234 3 to to IN cord-309161-ceahghs1 234 4 COVID covid NN cord-309161-ceahghs1 234 5 - - HYPH cord-309161-ceahghs1 234 6 complications complication NNS cord-309161-ceahghs1 234 7 , , , cord-309161-ceahghs1 234 8 while while IN cord-309161-ceahghs1 234 9 still still RB cord-309161-ceahghs1 234 10 largely largely RB cord-309161-ceahghs1 234 11 unknown unknown JJ cord-309161-ceahghs1 234 12 beyond beyond IN cord-309161-ceahghs1 234 13 older old JJR cord-309161-ceahghs1 234 14 age age NN cord-309161-ceahghs1 234 15 and and CC cord-309161-ceahghs1 234 16 pre pre JJ cord-309161-ceahghs1 234 17 - - JJ cord-309161-ceahghs1 234 18 existing existing JJ cord-309161-ceahghs1 234 19 diseases disease NNS cord-309161-ceahghs1 234 20 , , , cord-309161-ceahghs1 234 21 clearly clearly RB cord-309161-ceahghs1 234 22 depends depend VBZ cord-309161-ceahghs1 234 23 on on IN cord-309161-ceahghs1 234 24 ability ability NN cord-309161-ceahghs1 234 25 of of IN cord-309161-ceahghs1 234 26 the the DT cord-309161-ceahghs1 234 27 immune immune JJ cord-309161-ceahghs1 234 28 system system NN cord-309161-ceahghs1 234 29 to to TO cord-309161-ceahghs1 234 30 respond respond VB cord-309161-ceahghs1 234 31 robustly robustly RB cord-309161-ceahghs1 234 32 . . . cord-309161-ceahghs1 235 1 The the DT cord-309161-ceahghs1 235 2 relevance relevance NN cord-309161-ceahghs1 235 3 of of IN cord-309161-ceahghs1 235 4 immune immune JJ cord-309161-ceahghs1 235 5 senescence senescence NN cord-309161-ceahghs1 235 6 in in IN cord-309161-ceahghs1 235 7 COVID covid NN cord-309161-ceahghs1 235 8 - - HYPH cord-309161-ceahghs1 235 9 lethality lethality NN cord-309161-ceahghs1 235 10 has have VBZ cord-309161-ceahghs1 235 11 stimulated stimulate VBN cord-309161-ceahghs1 235 12 many many JJ cord-309161-ceahghs1 235 13 hypotheses hypothesis NNS cord-309161-ceahghs1 235 14 about about IN cord-309161-ceahghs1 235 15 geroscience geroscience NN cord-309161-ceahghs1 235 16 - - HYPH cord-309161-ceahghs1 235 17 related relate VBN cord-309161-ceahghs1 235 18 prevention prevention NN cord-309161-ceahghs1 235 19 and and CC cord-309161-ceahghs1 235 20 treatment treatment NN cord-309161-ceahghs1 236 1 ( ( -LRB- cord-309161-ceahghs1 236 2 Barzilai Barzilai NNP cord-309161-ceahghs1 236 3 et et NNP cord-309161-ceahghs1 236 4 al al NNP cord-309161-ceahghs1 236 5 . . NNP cord-309161-ceahghs1 236 6 , , , cord-309161-ceahghs1 236 7 2020 2020 CD cord-309161-ceahghs1 236 8 ; ; : cord-309161-ceahghs1 236 9 Salimi Salimi NNP cord-309161-ceahghs1 236 10 & & CC cord-309161-ceahghs1 236 11 Hamlyn Hamlyn NNP cord-309161-ceahghs1 236 12 , , , cord-309161-ceahghs1 236 13 2020 2020 CD cord-309161-ceahghs1 236 14 ; ; : cord-309161-ceahghs1 236 15 Sargiacomo Sargiacomo NNP cord-309161-ceahghs1 236 16 et et NNP cord-309161-ceahghs1 236 17 al al NNP cord-309161-ceahghs1 236 18 . . NNP cord-309161-ceahghs1 236 19 , , , cord-309161-ceahghs1 236 20 2020 2020 CD cord-309161-ceahghs1 236 21 ) ) -RRB- cord-309161-ceahghs1 236 22 . . . cord-309161-ceahghs1 237 1 While while IN cord-309161-ceahghs1 237 2 vaccination vaccination NN cord-309161-ceahghs1 237 3 is be VBZ cord-309161-ceahghs1 237 4 essential essential JJ cord-309161-ceahghs1 237 5 for for IN cord-309161-ceahghs1 237 6 traditional traditional JJ cord-309161-ceahghs1 237 7 prevention prevention NN cord-309161-ceahghs1 237 8 , , , cord-309161-ceahghs1 237 9 it -PRON- PRP cord-309161-ceahghs1 237 10 is be VBZ cord-309161-ceahghs1 237 11 not not RB cord-309161-ceahghs1 237 12 a a DT cord-309161-ceahghs1 237 13 universal universal JJ cord-309161-ceahghs1 237 14 solution solution NN cord-309161-ceahghs1 237 15 : : : cord-309161-ceahghs1 237 16 The the DT cord-309161-ceahghs1 237 17 elderly elderly JJ cord-309161-ceahghs1 237 18 have have VBP cord-309161-ceahghs1 237 19 poorer poor JJR cord-309161-ceahghs1 237 20 antibody antibody NN cord-309161-ceahghs1 237 21 responses response NNS cord-309161-ceahghs1 237 22 to to IN cord-309161-ceahghs1 237 23 vaccination vaccination NN cord-309161-ceahghs1 237 24 , , , cord-309161-ceahghs1 237 25 there there EX cord-309161-ceahghs1 237 26 are be VBP cord-309161-ceahghs1 237 27 many many JJ cord-309161-ceahghs1 237 28 strains strain NNS cord-309161-ceahghs1 237 29 of of IN cord-309161-ceahghs1 237 30 the the DT cord-309161-ceahghs1 237 31 current current JJ cord-309161-ceahghs1 237 32 virus virus NN cord-309161-ceahghs1 237 33 , , , cord-309161-ceahghs1 237 34 and and CC cord-309161-ceahghs1 237 35 there there EX cord-309161-ceahghs1 237 36 are be VBP cord-309161-ceahghs1 237 37 expected expect VBN cord-309161-ceahghs1 237 38 to to TO cord-309161-ceahghs1 237 39 be be VB cord-309161-ceahghs1 237 40 many many JJ cord-309161-ceahghs1 237 41 proliferations proliferation NNS cord-309161-ceahghs1 237 42 of of IN cord-309161-ceahghs1 237 43 future future JJ cord-309161-ceahghs1 237 44 viral viral JJ cord-309161-ceahghs1 237 45 strains strain NNS cord-309161-ceahghs1 237 46 novel novel JJ cord-309161-ceahghs1 237 47 to to IN cord-309161-ceahghs1 237 48 the the DT cord-309161-ceahghs1 237 49 human human JJ cord-309161-ceahghs1 237 50 body body NN cord-309161-ceahghs1 237 51 , , , cord-309161-ceahghs1 237 52 due due IN cord-309161-ceahghs1 237 53 to to IN cord-309161-ceahghs1 237 54 climate climate NN cord-309161-ceahghs1 237 55 change change NN cord-309161-ceahghs1 237 56 . . . cord-309161-ceahghs1 238 1 Therefore therefore RB cord-309161-ceahghs1 238 2 , , , cord-309161-ceahghs1 238 3 geroscience geroscience NN cord-309161-ceahghs1 238 4 interventions intervention NNS cord-309161-ceahghs1 238 5 have have VBP cord-309161-ceahghs1 238 6 unique unique JJ cord-309161-ceahghs1 238 7 universal universal JJ cord-309161-ceahghs1 238 8 importance importance NN cord-309161-ceahghs1 238 9 across across IN cord-309161-ceahghs1 238 10 time time NN cord-309161-ceahghs1 238 11 . . . cord-309161-ceahghs1 239 1 Pharmacological pharmacological JJ cord-309161-ceahghs1 239 2 interventions intervention NNS cord-309161-ceahghs1 239 3 have have VBP cord-309161-ceahghs1 239 4 been be VBN cord-309161-ceahghs1 239 5 suggested suggest VBN cord-309161-ceahghs1 239 6 for for IN cord-309161-ceahghs1 239 7 COVID COVID NNP cord-309161-ceahghs1 239 8 such such JJ cord-309161-ceahghs1 239 9 as as IN cord-309161-ceahghs1 239 10 rapalogs rapalogs NNP cord-309161-ceahghs1 239 11 , , , cord-309161-ceahghs1 239 12 senoytics senoytic NNS cord-309161-ceahghs1 239 13 , , , cord-309161-ceahghs1 239 14 Nicotinamide Nicotinamide NNP cord-309161-ceahghs1 239 15 Adenine Adenine NNP cord-309161-ceahghs1 239 16 Dinucleotide Dinucleotide NNP cord-309161-ceahghs1 239 17 NAD+ NAD+ NNP cord-309161-ceahghs1 239 18 , , , cord-309161-ceahghs1 239 19 and and CC cord-309161-ceahghs1 239 20 metformin metformin NN cord-309161-ceahghs1 239 21 for for IN cord-309161-ceahghs1 239 22 anti anti JJ cord-309161-ceahghs1 239 23 - - JJ cord-309161-ceahghs1 239 24 inflammation inflammation JJ cord-309161-ceahghs1 239 25 , , , cord-309161-ceahghs1 239 26 telomere telomere NN cord-309161-ceahghs1 239 27 stability stability NN cord-309161-ceahghs1 239 28 , , , cord-309161-ceahghs1 239 29 or or CC cord-309161-ceahghs1 239 30 to to TO cord-309161-ceahghs1 239 31 boost boost VB cord-309161-ceahghs1 239 32 vaccination vaccination NN cord-309161-ceahghs1 239 33 response response NN cord-309161-ceahghs1 239 34 ( ( -LRB- cord-309161-ceahghs1 239 35 Omran Omran NNP cord-309161-ceahghs1 239 36 & & CC cord-309161-ceahghs1 239 37 Almaliki Almaliki NNP cord-309161-ceahghs1 239 38 , , , cord-309161-ceahghs1 239 39 2020 2020 CD cord-309161-ceahghs1 239 40 ) ) -RRB- cord-309161-ceahghs1 239 41 . . . cord-309161-ceahghs1 240 1 Those those DT cord-309161-ceahghs1 240 2 with with IN cord-309161-ceahghs1 240 3 diabetes diabete NNS cord-309161-ceahghs1 240 4 appear appear VBP cord-309161-ceahghs1 240 5 to to TO cord-309161-ceahghs1 240 6 benefit benefit VB cord-309161-ceahghs1 240 7 from from IN cord-309161-ceahghs1 240 8 metformin metformin NNP cord-309161-ceahghs1 240 9 , , , cord-309161-ceahghs1 240 10 which which WDT cord-309161-ceahghs1 240 11 has have VBZ cord-309161-ceahghs1 240 12 hormetic hormetic JJ cord-309161-ceahghs1 240 13 properties property NNS cord-309161-ceahghs1 240 14 , , , cord-309161-ceahghs1 240 15 to to TO cord-309161-ceahghs1 240 16 prevent prevent VB cord-309161-ceahghs1 240 17 COVID covid NN cord-309161-ceahghs1 240 18 - - HYPH cord-309161-ceahghs1 240 19 related relate VBN cord-309161-ceahghs1 240 20 mortality mortality NN cord-309161-ceahghs1 240 21 ( ( -LRB- cord-309161-ceahghs1 240 22 Luo Luo NNP cord-309161-ceahghs1 240 23 et et NNP cord-309161-ceahghs1 240 24 al al NNP cord-309161-ceahghs1 240 25 . . NNP cord-309161-ceahghs1 240 26 , , , cord-309161-ceahghs1 240 27 2020 2020 CD cord-309161-ceahghs1 240 28 ) ) -RRB- cord-309161-ceahghs1 240 29 . . . cord-309161-ceahghs1 241 1 Beyond beyond IN cord-309161-ceahghs1 241 2 pharmacological pharmacological JJ cord-309161-ceahghs1 241 3 treatments treatment NNS cord-309161-ceahghs1 241 4 , , , cord-309161-ceahghs1 241 5 it -PRON- PRP cord-309161-ceahghs1 241 6 is be VBZ cord-309161-ceahghs1 241 7 likely likely RB cord-309161-ceahghs1 241 8 some some DT cord-309161-ceahghs1 241 9 of of IN cord-309161-ceahghs1 241 10 the the DT cord-309161-ceahghs1 241 11 interventions intervention NNS cord-309161-ceahghs1 241 12 for for IN cord-309161-ceahghs1 241 13 boosting boost VBG cord-309161-ceahghs1 241 14 stress stress NN cord-309161-ceahghs1 241 15 resilience resilience NN cord-309161-ceahghs1 241 16 in in IN cord-309161-ceahghs1 241 17 Table Table NNP cord-309161-ceahghs1 241 18 1 1 CD cord-309161-ceahghs1 241 19 may may MD cord-309161-ceahghs1 241 20 enhance enhance VB cord-309161-ceahghs1 241 21 resistance resistance NN cord-309161-ceahghs1 241 22 to to IN cord-309161-ceahghs1 241 23 viral viral JJ cord-309161-ceahghs1 241 24 infections infection NNS cord-309161-ceahghs1 241 25 , , , cord-309161-ceahghs1 241 26 from from IN cord-309161-ceahghs1 241 27 common common JJ cord-309161-ceahghs1 241 28 cold cold NN cord-309161-ceahghs1 241 29 to to IN cord-309161-ceahghs1 241 30 novel novel JJ cord-309161-ceahghs1 241 31 viruses virus NNS cord-309161-ceahghs1 241 32 . . . cord-309161-ceahghs1 242 1 The the DT cord-309161-ceahghs1 242 2 malleable malleable JJ cord-309161-ceahghs1 242 3 lifestyle lifestyle NN cord-309161-ceahghs1 242 4 behaviors behavior NNS cord-309161-ceahghs1 242 5 like like IN cord-309161-ceahghs1 242 6 fitness fitness NN cord-309161-ceahghs1 242 7 , , , cord-309161-ceahghs1 242 8 nutrition nutrition NN cord-309161-ceahghs1 242 9 , , , cord-309161-ceahghs1 242 10 sleep sleep NN cord-309161-ceahghs1 242 11 quality quality NN cord-309161-ceahghs1 242 12 , , , cord-309161-ceahghs1 242 13 and and CC cord-309161-ceahghs1 242 14 stress stress NN cord-309161-ceahghs1 242 15 reduction reduction NN cord-309161-ceahghs1 242 16 , , , cord-309161-ceahghs1 242 17 are be VBP cord-309161-ceahghs1 242 18 important important JJ cord-309161-ceahghs1 242 19 ways way NNS cord-309161-ceahghs1 242 20 to to TO cord-309161-ceahghs1 242 21 reduce reduce VB cord-309161-ceahghs1 242 22 insulin insulin NN cord-309161-ceahghs1 242 23 resistance resistance NN cord-309161-ceahghs1 242 24 and and CC cord-309161-ceahghs1 242 25 comorbidities comorbiditie NNS cord-309161-ceahghs1 242 26 , , , cord-309161-ceahghs1 242 27 and and CC cord-309161-ceahghs1 242 28 thus thus RB cord-309161-ceahghs1 242 29 may may MD cord-309161-ceahghs1 242 30 help help VB cord-309161-ceahghs1 242 31 prevent prevent VB cord-309161-ceahghs1 242 32 immune immune JJ cord-309161-ceahghs1 242 33 senescence senescence NN cord-309161-ceahghs1 242 34 and and CC cord-309161-ceahghs1 242 35 COVID covid JJ cord-309161-ceahghs1 242 36 complications complication NNS cord-309161-ceahghs1 242 37 . . . cord-309161-ceahghs1 243 1 One one CD cord-309161-ceahghs1 243 2 pathway pathway NN cord-309161-ceahghs1 243 3 through through IN cord-309161-ceahghs1 243 4 which which WDT cord-309161-ceahghs1 243 5 stress stress NN cord-309161-ceahghs1 243 6 resilience resilience NN cord-309161-ceahghs1 243 7 interventions intervention NNS cord-309161-ceahghs1 243 8 could could MD cord-309161-ceahghs1 243 9 impact impact VB cord-309161-ceahghs1 243 10 immunity immunity NN cord-309161-ceahghs1 243 11 is be VBZ cord-309161-ceahghs1 243 12 through through IN cord-309161-ceahghs1 243 13 stabilizing stabilize VBG cord-309161-ceahghs1 243 14 telomere telomere NN cord-309161-ceahghs1 243 15 length length NN cord-309161-ceahghs1 243 16 . . . cord-309161-ceahghs1 244 1 Short short JJ cord-309161-ceahghs1 244 2 telomeres telomere NNS cord-309161-ceahghs1 244 3 predict predict VBP cord-309161-ceahghs1 244 4 greater great JJR cord-309161-ceahghs1 244 5 vulnerability vulnerability NN cord-309161-ceahghs1 244 6 to to IN cord-309161-ceahghs1 244 7 rhinovirus rhinovirus NN cord-309161-ceahghs1 244 8 infection infection NN cord-309161-ceahghs1 244 9 , , , cord-309161-ceahghs1 244 10 acute acute JJ cord-309161-ceahghs1 244 11 respiratory respiratory JJ cord-309161-ceahghs1 244 12 syndrome syndrome NN cord-309161-ceahghs1 244 13 disorders disorder NNS cord-309161-ceahghs1 244 14 , , , cord-309161-ceahghs1 244 15 and and CC cord-309161-ceahghs1 244 16 mortality mortality NN cord-309161-ceahghs1 244 17 from from IN cord-309161-ceahghs1 244 18 sepsis sepsis NN cord-309161-ceahghs1 245 1 ( ( -LRB- cord-309161-ceahghs1 245 2 Cohen Cohen NNP cord-309161-ceahghs1 245 3 et et NNP cord-309161-ceahghs1 245 4 al al NNP cord-309161-ceahghs1 245 5 . . NNP cord-309161-ceahghs1 245 6 , , , cord-309161-ceahghs1 245 7 2013 2013 CD cord-309161-ceahghs1 245 8 ; ; : cord-309161-ceahghs1 245 9 Liu Liu NNP cord-309161-ceahghs1 245 10 et et NNP cord-309161-ceahghs1 245 11 al al NNP cord-309161-ceahghs1 245 12 . . NNP cord-309161-ceahghs1 245 13 , , , cord-309161-ceahghs1 245 14 2020 2020 CD cord-309161-ceahghs1 245 15 ) ) -RRB- cord-309161-ceahghs1 245 16 . . . cord-309161-ceahghs1 246 1 Chronic chronic JJ cord-309161-ceahghs1 246 2 psychological psychological JJ cord-309161-ceahghs1 246 3 stress stress NN cord-309161-ceahghs1 246 4 shortens shorten VBZ cord-309161-ceahghs1 246 5 telomeres telomere NNS cord-309161-ceahghs1 246 6 in in IN cord-309161-ceahghs1 246 7 animal animal NN cord-309161-ceahghs1 246 8 studies study NNS cord-309161-ceahghs1 246 9 and and CC cord-309161-ceahghs1 246 10 impairs impair VBZ cord-309161-ceahghs1 246 11 viral viral JJ cord-309161-ceahghs1 246 12 immunity immunity NN cord-309161-ceahghs1 246 13 ( ( -LRB- cord-309161-ceahghs1 246 14 Cohen Cohen NNP cord-309161-ceahghs1 246 15 et et NNP cord-309161-ceahghs1 246 16 al al NNP cord-309161-ceahghs1 246 17 . . . cord-309161-ceahghs1 247 1 , , , cord-309161-ceahghs1 247 2 1991 1991 CD cord-309161-ceahghs1 247 3 ( ( -LRB- cord-309161-ceahghs1 247 4 Cohen Cohen NNP cord-309161-ceahghs1 247 5 et et NNP cord-309161-ceahghs1 247 6 al al NNP cord-309161-ceahghs1 247 7 . . NNP cord-309161-ceahghs1 247 8 , , , cord-309161-ceahghs1 247 9 , , , cord-309161-ceahghs1 247 10 1998 1998 CD cord-309161-ceahghs1 247 11 . . . cord-309161-ceahghs1 248 1 Short short JJ cord-309161-ceahghs1 248 2 telomeres telomere NNS cord-309161-ceahghs1 248 3 indicate indicate VBP cord-309161-ceahghs1 248 4 lower low JJR cord-309161-ceahghs1 248 5 ability ability NN cord-309161-ceahghs1 248 6 to to TO cord-309161-ceahghs1 248 7 mount mount VB cord-309161-ceahghs1 248 8 a a DT cord-309161-ceahghs1 248 9 robust robust JJ cord-309161-ceahghs1 248 10 replicative replicative JJ cord-309161-ceahghs1 248 11 T t NN cord-309161-ceahghs1 248 12 cell cell NN cord-309161-ceahghs1 248 13 response response NN cord-309161-ceahghs1 248 14 , , , cord-309161-ceahghs1 248 15 and and CC cord-309161-ceahghs1 248 16 this this DT cord-309161-ceahghs1 248 17 may may MD cord-309161-ceahghs1 248 18 be be VB cord-309161-ceahghs1 248 19 a a DT cord-309161-ceahghs1 248 20 critical critical JJ cord-309161-ceahghs1 248 21 or or CC cord-309161-ceahghs1 248 22 even even RB cord-309161-ceahghs1 248 23 fatal fatal JJ cord-309161-ceahghs1 249 1 J J NNP cord-309161-ceahghs1 249 2 o o NNP cord-309161-ceahghs1 250 1 u u NNP cord-309161-ceahghs1 250 2 r r NNP cord-309161-ceahghs1 250 3 n n NN cord-309161-ceahghs1 250 4 a a DT cord-309161-ceahghs1 250 5 l l NN cord-309161-ceahghs1 250 6 P p NN cord-309161-ceahghs1 250 7 r r NN cord-309161-ceahghs1 250 8 e e NN cord-309161-ceahghs1 251 1 -p -p : cord-309161-ceahghs1 252 1 r r NN cord-309161-ceahghs1 252 2 o o NN cord-309161-ceahghs1 252 3 o o NN cord-309161-ceahghs1 252 4 f f NN cord-309161-ceahghs1 252 5 limitation limitation NN cord-309161-ceahghs1 252 6 in in IN cord-309161-ceahghs1 252 7 the the DT cord-309161-ceahghs1 252 8 face face NN cord-309161-ceahghs1 252 9 of of IN cord-309161-ceahghs1 252 10 COVID COVID NNP cord-309161-ceahghs1 252 11 related relate VBN cord-309161-ceahghs1 252 12 lymphopenia lymphopenia NNP cord-309161-ceahghs1 252 13 ( ( -LRB- cord-309161-ceahghs1 252 14 Aviv Aviv NNP cord-309161-ceahghs1 252 15 , , , cord-309161-ceahghs1 252 16 2020 2020 CD cord-309161-ceahghs1 252 17 ) ) -RRB- cord-309161-ceahghs1 252 18 . . . cord-309161-ceahghs1 253 1 In in IN cord-309161-ceahghs1 253 2 short short JJ cord-309161-ceahghs1 253 3 , , , cord-309161-ceahghs1 253 4 COVID-19 COVID-19 NNP cord-309161-ceahghs1 253 5 presents present VBZ cord-309161-ceahghs1 253 6 a a DT cord-309161-ceahghs1 253 7 potent potent JJ cord-309161-ceahghs1 253 8 example example NN cord-309161-ceahghs1 253 9 of of IN cord-309161-ceahghs1 253 10 the the DT cord-309161-ceahghs1 253 11 potential potential NN cord-309161-ceahghs1 253 12 for for IN cord-309161-ceahghs1 253 13 using use VBG cord-309161-ceahghs1 253 14 indices index NNS cord-309161-ceahghs1 253 15 of of IN cord-309161-ceahghs1 253 16 aging age VBG cord-309161-ceahghs1 253 17 as as IN cord-309161-ceahghs1 253 18 predictors predictor NNS cord-309161-ceahghs1 253 19 of of IN cord-309161-ceahghs1 253 20 disease disease NN cord-309161-ceahghs1 253 21 and and CC cord-309161-ceahghs1 253 22 targets target NNS cord-309161-ceahghs1 253 23 of of IN cord-309161-ceahghs1 253 24 intervention intervention NN cord-309161-ceahghs1 253 25 . . . cord-309161-ceahghs1 254 1 The the DT cord-309161-ceahghs1 254 2 goal goal NN cord-309161-ceahghs1 254 3 of of IN cord-309161-ceahghs1 254 4 geroscience geroscience NN cord-309161-ceahghs1 254 5 is be VBZ cord-309161-ceahghs1 254 6 to to TO cord-309161-ceahghs1 254 7 slow slow VB cord-309161-ceahghs1 254 8 aging aging NN cord-309161-ceahghs1 254 9 to to TO cord-309161-ceahghs1 254 10 improve improve VB cord-309161-ceahghs1 254 11 healthspan healthspan NNP cord-309161-ceahghs1 254 12 . . . cord-309161-ceahghs1 255 1 In in IN cord-309161-ceahghs1 255 2 the the DT cord-309161-ceahghs1 255 3 next next JJ cord-309161-ceahghs1 255 4 generation generation NN cord-309161-ceahghs1 255 5 of of IN cord-309161-ceahghs1 255 6 research research NN cord-309161-ceahghs1 255 7 , , , cord-309161-ceahghs1 255 8 we -PRON- PRP cord-309161-ceahghs1 255 9 will will MD cord-309161-ceahghs1 255 10 benefit benefit VB cord-309161-ceahghs1 255 11 greatly greatly RB cord-309161-ceahghs1 255 12 from from IN cord-309161-ceahghs1 255 13 incorporating incorporate VBG cord-309161-ceahghs1 255 14 the the DT cord-309161-ceahghs1 255 15 large large JJ cord-309161-ceahghs1 255 16 malleable malleable JJ cord-309161-ceahghs1 255 17 factors factor NNS cord-309161-ceahghs1 255 18 that that WDT cord-309161-ceahghs1 255 19 impact impact VBP cord-309161-ceahghs1 255 20 human human JJ cord-309161-ceahghs1 255 21 aging aging NN cord-309161-ceahghs1 255 22 - - HYPH cord-309161-ceahghs1 255 23 biobehavioral biobehavioral JJ cord-309161-ceahghs1 255 24 and and CC cord-309161-ceahghs1 255 25 social social JJ cord-309161-ceahghs1 255 26 factors factor NNS cord-309161-ceahghs1 255 27 . . . cord-309161-ceahghs1 256 1 The the DT cord-309161-ceahghs1 256 2 NIA NIA NNP cord-309161-ceahghs1 256 3 's 's POS cord-309161-ceahghs1 256 4 Intervention Intervention NNP cord-309161-ceahghs1 256 5 and and CC cord-309161-ceahghs1 256 6 Testing Testing NNP cord-309161-ceahghs1 256 7 Program Program NNP cord-309161-ceahghs1 256 8 , , , cord-309161-ceahghs1 256 9 a a DT cord-309161-ceahghs1 256 10 multi multi JJ cord-309161-ceahghs1 256 11 - - JJ cord-309161-ceahghs1 256 12 institutional institutional JJ cord-309161-ceahghs1 256 13 infrastructure infrastructure NN cord-309161-ceahghs1 256 14 to to TO cord-309161-ceahghs1 256 15 study study VB cord-309161-ceahghs1 256 16 biological biological JJ cord-309161-ceahghs1 256 17 agents agent NNS cord-309161-ceahghs1 256 18 for for IN cord-309161-ceahghs1 256 19 healthspan healthspan NNP cord-309161-ceahghs1 256 20 in in IN cord-309161-ceahghs1 256 21 animals animal NNS cord-309161-ceahghs1 256 22 is be VBZ cord-309161-ceahghs1 256 23 a a DT cord-309161-ceahghs1 256 24 model model NN cord-309161-ceahghs1 256 25 that that WDT cord-309161-ceahghs1 256 26 can can MD cord-309161-ceahghs1 256 27 be be VB cord-309161-ceahghs1 256 28 extended extend VBN cord-309161-ceahghs1 256 29 to to IN cord-309161-ceahghs1 256 30 human human JJ cord-309161-ceahghs1 256 31 trials trial NNS cord-309161-ceahghs1 256 32 that that WDT cord-309161-ceahghs1 256 33 takes take VBZ cord-309161-ceahghs1 256 34 into into IN cord-309161-ceahghs1 256 35 account account NN cord-309161-ceahghs1 256 36 the the DT cord-309161-ceahghs1 256 37 social social JJ cord-309161-ceahghs1 256 38 and and CC cord-309161-ceahghs1 256 39 behavioral behavioral JJ cord-309161-ceahghs1 256 40 factors factor NNS cord-309161-ceahghs1 257 1 ( ( -LRB- cord-309161-ceahghs1 257 2 Moffitt Moffitt NNP cord-309161-ceahghs1 257 3 , , , cord-309161-ceahghs1 257 4 this this DT cord-309161-ceahghs1 257 5 issue issue NN cord-309161-ceahghs1 257 6 ) ) -RRB- cord-309161-ceahghs1 257 7 . . . cord-309161-ceahghs1 258 1 The the DT cord-309161-ceahghs1 258 2 social social JJ cord-309161-ceahghs1 258 3 hallmarks hallmark NNS cord-309161-ceahghs1 258 4 of of IN cord-309161-ceahghs1 258 5 aging age VBG cord-309161-ceahghs1 258 6 shape shape NN cord-309161-ceahghs1 258 7 rate rate NN cord-309161-ceahghs1 258 8 of of IN cord-309161-ceahghs1 258 9 aging age VBG cord-309161-ceahghs1 258 10 , , , cord-309161-ceahghs1 258 11 in in IN cord-309161-ceahghs1 258 12 part part NN cord-309161-ceahghs1 258 13 through through IN cord-309161-ceahghs1 258 14 toxic toxic JJ cord-309161-ceahghs1 258 15 stress stress NN cord-309161-ceahghs1 258 16 processes process NNS cord-309161-ceahghs1 258 17 . . . cord-309161-ceahghs1 259 1 The the DT cord-309161-ceahghs1 259 2 understanding understanding NN cord-309161-ceahghs1 259 3 of of IN cord-309161-ceahghs1 259 4 toxic toxic JJ cord-309161-ceahghs1 259 5 stress stress NN cord-309161-ceahghs1 259 6 and and CC cord-309161-ceahghs1 259 7 hormetic hormetic JJ cord-309161-ceahghs1 259 8 stress stress NN cord-309161-ceahghs1 259 9 as as IN cord-309161-ceahghs1 259 10 factors factor NNS cord-309161-ceahghs1 259 11 shaping shape VBG cord-309161-ceahghs1 259 12 aging age VBG cord-309161-ceahghs1 259 13 will will MD cord-309161-ceahghs1 259 14 have have VB cord-309161-ceahghs1 259 15 implications implication NNS cord-309161-ceahghs1 259 16 for for IN cord-309161-ceahghs1 259 17 interventions intervention NNS cord-309161-ceahghs1 259 18 . . . cord-309161-ceahghs1 260 1 Stress stress NN cord-309161-ceahghs1 260 2 resilience resilience NN cord-309161-ceahghs1 260 3 , , , cord-309161-ceahghs1 260 4 the the DT cord-309161-ceahghs1 260 5 ability ability NN cord-309161-ceahghs1 260 6 to to TO cord-309161-ceahghs1 260 7 recover recover VB cord-309161-ceahghs1 260 8 quickly quickly RB cord-309161-ceahghs1 260 9 and and CC cord-309161-ceahghs1 260 10 turn turn VB cord-309161-ceahghs1 260 11 on on RP cord-309161-ceahghs1 260 12 rejuvenative rejuvenative JJ cord-309161-ceahghs1 260 13 processes process NNS cord-309161-ceahghs1 260 14 , , , cord-309161-ceahghs1 260 15 is be VBZ cord-309161-ceahghs1 260 16 an an DT cord-309161-ceahghs1 260 17 important important JJ cord-309161-ceahghs1 260 18 dynamic dynamic JJ cord-309161-ceahghs1 260 19 endophenotype endophenotype NN cord-309161-ceahghs1 260 20 of of IN cord-309161-ceahghs1 260 21 healthy healthy JJ cord-309161-ceahghs1 260 22 aging aging NN cord-309161-ceahghs1 260 23 . . . cord-309161-ceahghs1 261 1 It -PRON- PRP cord-309161-ceahghs1 261 2 remains remain VBZ cord-309161-ceahghs1 261 3 to to TO cord-309161-ceahghs1 261 4 be be VB cord-309161-ceahghs1 261 5 seen see VBN cord-309161-ceahghs1 261 6 how how WRB cord-309161-ceahghs1 261 7 much much JJ cord-309161-ceahghs1 261 8 resilience resilience NN cord-309161-ceahghs1 261 9 is be VBZ cord-309161-ceahghs1 261 10 merely merely RB cord-309161-ceahghs1 261 11 a a DT cord-309161-ceahghs1 261 12 characteristic characteristic NN cord-309161-ceahghs1 261 13 of of IN cord-309161-ceahghs1 261 14 healthy healthy JJ cord-309161-ceahghs1 261 15 aging aging NN cord-309161-ceahghs1 261 16 or or CC cord-309161-ceahghs1 261 17 a a DT cord-309161-ceahghs1 261 18 causal causal JJ cord-309161-ceahghs1 261 19 factor factor NN cord-309161-ceahghs1 261 20 , , , cord-309161-ceahghs1 261 21 although although IN cord-309161-ceahghs1 261 22 much much JJ cord-309161-ceahghs1 261 23 evidence evidence NN cord-309161-ceahghs1 261 24 reviewed review VBN cord-309161-ceahghs1 261 25 here here RB cord-309161-ceahghs1 261 26 suggests suggest VBZ cord-309161-ceahghs1 261 27 it -PRON- PRP cord-309161-ceahghs1 261 28 is be VBZ cord-309161-ceahghs1 261 29 at at IN cord-309161-ceahghs1 261 30 least least JJS cord-309161-ceahghs1 261 31 partly partly RB cord-309161-ceahghs1 261 32 causal causal JJ cord-309161-ceahghs1 261 33 . . . cord-309161-ceahghs1 262 1 A a DT cord-309161-ceahghs1 262 2 better well JJR cord-309161-ceahghs1 262 3 understanding understanding NN cord-309161-ceahghs1 262 4 of of IN cord-309161-ceahghs1 262 5 how how WRB cord-309161-ceahghs1 262 6 to to TO cord-309161-ceahghs1 262 7 measure measure VB cord-309161-ceahghs1 262 8 stress stress NN cord-309161-ceahghs1 262 9 resilience resilience NN cord-309161-ceahghs1 262 10 , , , cord-309161-ceahghs1 262 11 and and CC cord-309161-ceahghs1 262 12 to to TO cord-309161-ceahghs1 262 13 promote promote VB cord-309161-ceahghs1 262 14 stress stress NN cord-309161-ceahghs1 262 15 resilience resilience NN cord-309161-ceahghs1 262 16 at at IN cord-309161-ceahghs1 262 17 the the DT cord-309161-ceahghs1 262 18 cellular cellular JJ cord-309161-ceahghs1 262 19 , , , cord-309161-ceahghs1 262 20 physiological physiological JJ cord-309161-ceahghs1 262 21 and and CC cord-309161-ceahghs1 262 22 psychosocial psychosocial JJ cord-309161-ceahghs1 262 23 levels level NNS cord-309161-ceahghs1 262 24 will will MD cord-309161-ceahghs1 262 25 lead lead VB cord-309161-ceahghs1 262 26 to to IN cord-309161-ceahghs1 262 27 important important JJ cord-309161-ceahghs1 262 28 gains gain NNS cord-309161-ceahghs1 262 29 in in IN cord-309161-ceahghs1 262 30 slowing slow VBG cord-309161-ceahghs1 262 31 aging age VBG cord-309161-ceahghs1 262 32 . . . cord-309161-ceahghs1 263 1 The the DT cord-309161-ceahghs1 263 2 science science NN cord-309161-ceahghs1 263 3 of of IN cord-309161-ceahghs1 263 4 stress stress NN cord-309161-ceahghs1 263 5 is be VBZ cord-309161-ceahghs1 263 6 an an DT cord-309161-ceahghs1 263 7 integral integral JJ cord-309161-ceahghs1 263 8 part part NN cord-309161-ceahghs1 263 9 of of IN cord-309161-ceahghs1 263 10 geroscience geroscience NN cord-309161-ceahghs1 263 11 , , , cord-309161-ceahghs1 263 12 and and CC cord-309161-ceahghs1 263 13 offers offer VBZ cord-309161-ceahghs1 263 14 insights insight NNS cord-309161-ceahghs1 263 15 on on IN cord-309161-ceahghs1 263 16 how how WRB cord-309161-ceahghs1 263 17 to to TO cord-309161-ceahghs1 263 18 harness harness VB cord-309161-ceahghs1 263 19 stress stress NN cord-309161-ceahghs1 263 20 for for IN cord-309161-ceahghs1 263 21 optimal optimal JJ cord-309161-ceahghs1 263 22 longevity longevity NN cord-309161-ceahghs1 263 23 , , , cord-309161-ceahghs1 263 24 and and CC cord-309161-ceahghs1 263 25 implications implication NNS cord-309161-ceahghs1 263 26 for for IN cord-309161-ceahghs1 263 27 how how WRB cord-309161-ceahghs1 263 28 to to TO cord-309161-ceahghs1 263 29 conduct conduct VB cord-309161-ceahghs1 263 30 the the DT cord-309161-ceahghs1 263 31 most most RBS cord-309161-ceahghs1 263 32 effective effective JJ cord-309161-ceahghs1 263 33 interventions intervention NNS cord-309161-ceahghs1 263 34 incorporating incorporate VBG cord-309161-ceahghs1 263 35 these these DT cord-309161-ceahghs1 263 36 stress stress NN cord-309161-ceahghs1 263 37 processes process NNS cord-309161-ceahghs1 263 38 as as IN cord-309161-ceahghs1 263 39 both both DT cord-309161-ceahghs1 263 40 target target NN cord-309161-ceahghs1 263 41 mechanisms mechanism NNS cord-309161-ceahghs1 263 42 and and CC cord-309161-ceahghs1 263 43 outcomes outcome NNS cord-309161-ceahghs1 263 44 . . . cord-309161-ceahghs1 264 1 By by IN cord-309161-ceahghs1 264 2 having have VBG cord-309161-ceahghs1 264 3 an an DT cord-309161-ceahghs1 264 4 integrative integrative JJ cord-309161-ceahghs1 264 5 paradigm paradigm NN cord-309161-ceahghs1 264 6 that that WDT cord-309161-ceahghs1 264 7 can can MD cord-309161-ceahghs1 264 8 be be VB cord-309161-ceahghs1 264 9 examined examine VBN cord-309161-ceahghs1 264 10 across across IN cord-309161-ceahghs1 264 11 levels level NNS cord-309161-ceahghs1 264 12 , , , cord-309161-ceahghs1 264 13 we -PRON- PRP cord-309161-ceahghs1 264 14 can can MD cord-309161-ceahghs1 264 15 reduce reduce VB cord-309161-ceahghs1 264 16 the the DT cord-309161-ceahghs1 264 17 gap gap NN cord-309161-ceahghs1 264 18 between between IN cord-309161-ceahghs1 264 19 physiological physiological JJ cord-309161-ceahghs1 264 20 stress stress NN cord-309161-ceahghs1 264 21 research research NN cord-309161-ceahghs1 264 22 in in IN cord-309161-ceahghs1 264 23 model model NN cord-309161-ceahghs1 264 24 organisms organism NNS cord-309161-ceahghs1 264 25 and and CC cord-309161-ceahghs1 264 26 human human JJ cord-309161-ceahghs1 264 27 research research NN cord-309161-ceahghs1 264 28 on on IN cord-309161-ceahghs1 264 29 stress stress NN cord-309161-ceahghs1 264 30 , , , cord-309161-ceahghs1 264 31 resilience resilience NN cord-309161-ceahghs1 264 32 and and CC cord-309161-ceahghs1 264 33 adaptation adaptation NN cord-309161-ceahghs1 264 34 . . . cord-309161-ceahghs1 265 1 There there EX cord-309161-ceahghs1 265 2 are be VBP cord-309161-ceahghs1 265 3 many many JJ cord-309161-ceahghs1 265 4 ways way NNS cord-309161-ceahghs1 265 5 to to TO cord-309161-ceahghs1 265 6 measure measure VB cord-309161-ceahghs1 265 7 biological biological JJ cord-309161-ceahghs1 265 8 aging aging NN cord-309161-ceahghs1 265 9 in in IN cord-309161-ceahghs1 265 10 humans human NNS cord-309161-ceahghs1 265 11 that that WDT cord-309161-ceahghs1 265 12 can can MD cord-309161-ceahghs1 265 13 serve serve VB cord-309161-ceahghs1 265 14 as as IN cord-309161-ceahghs1 265 15 a a DT cord-309161-ceahghs1 265 16 barometer barometer NN cord-309161-ceahghs1 265 17 of of IN cord-309161-ceahghs1 265 18 change change NN cord-309161-ceahghs1 265 19 for for IN cord-309161-ceahghs1 265 20 interventions intervention NNS cord-309161-ceahghs1 265 21 . . . cord-309161-ceahghs1 266 1 This this DT cord-309161-ceahghs1 266 2 includes include VBZ cord-309161-ceahghs1 266 3 cellular cellular JJ cord-309161-ceahghs1 266 4 level level NN cord-309161-ceahghs1 266 5 markers marker NNS cord-309161-ceahghs1 266 6 , , , cord-309161-ceahghs1 266 7 multi multi JJ cord-309161-ceahghs1 266 8 - - JJ cord-309161-ceahghs1 266 9 system system JJ cord-309161-ceahghs1 266 10 composites composite NNS cord-309161-ceahghs1 266 11 , , , cord-309161-ceahghs1 266 12 and and CC cord-309161-ceahghs1 266 13 ways way NNS cord-309161-ceahghs1 266 14 of of IN cord-309161-ceahghs1 266 15 examining examine VBG cord-309161-ceahghs1 266 16 dynamic dynamic JJ cord-309161-ceahghs1 266 17 stress stress NN cord-309161-ceahghs1 266 18 resilience resilience NN cord-309161-ceahghs1 266 19 , , , cord-309161-ceahghs1 266 20 as as IN cord-309161-ceahghs1 266 21 reviewed review VBN cord-309161-ceahghs1 266 22 . . . cord-309161-ceahghs1 267 1 This this DT cord-309161-ceahghs1 267 2 J J NNP cord-309161-ceahghs1 267 3 o o NN cord-309161-ceahghs1 267 4 u u NN cord-309161-ceahghs1 267 5 r r NN cord-309161-ceahghs1 267 6 n n NN cord-309161-ceahghs1 267 7 a a DT cord-309161-ceahghs1 267 8 l l NN cord-309161-ceahghs1 267 9 P p NN cord-309161-ceahghs1 267 10 r r NN cord-309161-ceahghs1 267 11 e e NN cord-309161-ceahghs1 267 12 -p -p NN cord-309161-ceahghs1 268 1 r r LS cord-309161-ceahghs1 269 1 o o UH cord-309161-ceahghs1 270 1 o o UH cord-309161-ceahghs1 270 2 f f NNP cord-309161-ceahghs1 270 3 can can MD cord-309161-ceahghs1 270 4 include include VB cord-309161-ceahghs1 270 5 recovery recovery NN cord-309161-ceahghs1 270 6 from from IN cord-309161-ceahghs1 270 7 a a DT cord-309161-ceahghs1 270 8 medical medical JJ cord-309161-ceahghs1 270 9 event event NN cord-309161-ceahghs1 270 10 in in IN cord-309161-ceahghs1 270 11 the the DT cord-309161-ceahghs1 270 12 elderly elderly JJ cord-309161-ceahghs1 270 13 , , , cord-309161-ceahghs1 270 14 but but CC cord-309161-ceahghs1 270 15 also also RB cord-309161-ceahghs1 270 16 recovery recovery NN cord-309161-ceahghs1 270 17 to to IN cord-309161-ceahghs1 270 18 standardized standardized JJ cord-309161-ceahghs1 270 19 challenges challenge NNS cord-309161-ceahghs1 270 20 , , , cord-309161-ceahghs1 270 21 and and CC cord-309161-ceahghs1 270 22 to to IN cord-309161-ceahghs1 270 23 naturalistic naturalistic JJ cord-309161-ceahghs1 270 24 stressors stressor NNS cord-309161-ceahghs1 270 25 . . . cord-309161-ceahghs1 271 1 Geroscience Geroscience NNP cord-309161-ceahghs1 271 2 offers offer VBZ cord-309161-ceahghs1 271 3 an an DT cord-309161-ceahghs1 271 4 exciting exciting JJ cord-309161-ceahghs1 271 5 opportunity opportunity NN cord-309161-ceahghs1 271 6 for for IN cord-309161-ceahghs1 271 7 high high JJ cord-309161-ceahghs1 271 8 feasibility feasibility NN cord-309161-ceahghs1 271 9 impact impact NN cord-309161-ceahghs1 271 10 interventions intervention NNS cord-309161-ceahghs1 271 11 . . . cord-309161-ceahghs1 272 1 This this DT cord-309161-ceahghs1 272 2 integrative integrative JJ cord-309161-ceahghs1 272 3 paradigm paradigm NN cord-309161-ceahghs1 272 4 can can MD cord-309161-ceahghs1 272 5 shape shape VB cord-309161-ceahghs1 272 6 the the DT cord-309161-ceahghs1 272 7 next next JJ cord-309161-ceahghs1 272 8 generation generation NN cord-309161-ceahghs1 272 9 of of IN cord-309161-ceahghs1 272 10 researchers researcher NNS cord-309161-ceahghs1 272 11 . . . cord-309161-ceahghs1 273 1 The the DT cord-309161-ceahghs1 273 2 training training NN cord-309161-ceahghs1 273 3 models model NNS cord-309161-ceahghs1 273 4 need need VBP cord-309161-ceahghs1 273 5 to to TO cord-309161-ceahghs1 273 6 change change VB cord-309161-ceahghs1 273 7 to to TO cord-309161-ceahghs1 273 8 bridge bridge VB cord-309161-ceahghs1 273 9 the the DT cord-309161-ceahghs1 273 10 many many JJ cord-309161-ceahghs1 273 11 fields field NNS cord-309161-ceahghs1 273 12 as as IN cord-309161-ceahghs1 273 13 outlined outline VBN cord-309161-ceahghs1 273 14 by by IN cord-309161-ceahghs1 273 15 pioneers pioneer NNS cord-309161-ceahghs1 273 16 in in IN cord-309161-ceahghs1 273 17 geroscience geroscience NNP cord-309161-ceahghs1 274 1 ( ( -LRB- cord-309161-ceahghs1 274 2 Newman Newman NNP cord-309161-ceahghs1 274 3 et et NNP cord-309161-ceahghs1 274 4 al al NNP cord-309161-ceahghs1 274 5 . . NNP cord-309161-ceahghs1 274 6 , , , cord-309161-ceahghs1 274 7 2019 2019 CD cord-309161-ceahghs1 274 8 ) ) -RRB- cord-309161-ceahghs1 274 9 . . . cord-309161-ceahghs1 275 1 Models model NNS cord-309161-ceahghs1 275 2 which which WDT cord-309161-ceahghs1 275 3 are be VBP cord-309161-ceahghs1 275 4 focused focus VBN cord-309161-ceahghs1 275 5 on on IN cord-309161-ceahghs1 275 6 pharmacological pharmacological JJ cord-309161-ceahghs1 275 7 interventions intervention NNS cord-309161-ceahghs1 275 8 must must MD cord-309161-ceahghs1 275 9 expand expand VB cord-309161-ceahghs1 275 10 to to TO cord-309161-ceahghs1 275 11 be be VB cord-309161-ceahghs1 275 12 inclusive inclusive JJ cord-309161-ceahghs1 275 13 of of IN cord-309161-ceahghs1 275 14 both both DT cord-309161-ceahghs1 275 15 social social JJ cord-309161-ceahghs1 275 16 and and CC cord-309161-ceahghs1 275 17 behavioral behavioral JJ cord-309161-ceahghs1 275 18 interventions intervention NNS cord-309161-ceahghs1 275 19 , , , cord-309161-ceahghs1 275 20 the the DT cord-309161-ceahghs1 275 21 current current JJ cord-309161-ceahghs1 275 22 ' ' `` cord-309161-ceahghs1 275 23 big big JJ cord-309161-ceahghs1 275 24 levers lever NNS cord-309161-ceahghs1 275 25 . . . cord-309161-ceahghs1 275 26 ' ' '' cord-309161-ceahghs1 276 1 Lastly lastly RB cord-309161-ceahghs1 276 2 , , , cord-309161-ceahghs1 276 3 this this DT cord-309161-ceahghs1 276 4 field field NN cord-309161-ceahghs1 276 5 , , , cord-309161-ceahghs1 276 6 like like IN cord-309161-ceahghs1 276 7 all all DT cord-309161-ceahghs1 276 8 of of IN cord-309161-ceahghs1 276 9 science science NN cord-309161-ceahghs1 276 10 , , , cord-309161-ceahghs1 276 11 needs need VBZ cord-309161-ceahghs1 276 12 to to TO cord-309161-ceahghs1 276 13 actively actively RB cord-309161-ceahghs1 276 14 encourage encourage VB cord-309161-ceahghs1 276 15 and and CC cord-309161-ceahghs1 276 16 support support VB cord-309161-ceahghs1 276 17 young young JJ cord-309161-ceahghs1 276 18 investigators investigator NNS cord-309161-ceahghs1 276 19 from from IN cord-309161-ceahghs1 276 20 diverse diverse JJ cord-309161-ceahghs1 276 21 and and CC cord-309161-ceahghs1 276 22 underprivileged underprivileged JJ cord-309161-ceahghs1 276 23 backgrounds background NNS cord-309161-ceahghs1 276 24 to to TO cord-309161-ceahghs1 276 25 enter enter VB cord-309161-ceahghs1 276 26 this this DT cord-309161-ceahghs1 276 27 important important JJ cord-309161-ceahghs1 276 28 and and CC cord-309161-ceahghs1 276 29 growing grow VBG cord-309161-ceahghs1 276 30 field field NN cord-309161-ceahghs1 276 31 which which WDT cord-309161-ceahghs1 276 32 has have VBZ cord-309161-ceahghs1 276 33 the the DT cord-309161-ceahghs1 276 34 potential potential NN cord-309161-ceahghs1 276 35 to to TO cord-309161-ceahghs1 276 36 minimize minimize VB cord-309161-ceahghs1 276 37 socioeconomic socioeconomic JJ cord-309161-ceahghs1 276 38 and and CC cord-309161-ceahghs1 276 39 ethnic ethnic JJ cord-309161-ceahghs1 276 40 / / SYM cord-309161-ceahghs1 276 41 racial racial JJ cord-309161-ceahghs1 276 42 health health NN cord-309161-ceahghs1 276 43 disparities disparity NNS cord-309161-ceahghs1 276 44 not not RB cord-309161-ceahghs1 276 45 just just RB cord-309161-ceahghs1 276 46 for for IN cord-309161-ceahghs1 276 47 equity equity NN cord-309161-ceahghs1 276 48 but but CC cord-309161-ceahghs1 276 49 for for IN cord-309161-ceahghs1 276 50 the the DT cord-309161-ceahghs1 276 51 improved improved JJ cord-309161-ceahghs1 276 52 science science NN cord-309161-ceahghs1 276 53 that that WDT cord-309161-ceahghs1 276 54 results result VBZ cord-309161-ceahghs1 276 55 with with IN cord-309161-ceahghs1 276 56 diverse diverse JJ cord-309161-ceahghs1 276 57 life life NN cord-309161-ceahghs1 276 58 experiences experience NNS cord-309161-ceahghs1 276 59 and and CC cord-309161-ceahghs1 276 60 perspectives perspective NNS cord-309161-ceahghs1 276 61 . . . cord-309161-ceahghs1 277 1 Frameworks framework NNS cord-309161-ceahghs1 277 2 for for IN cord-309161-ceahghs1 277 3 proof proof NN cord-309161-ceahghs1 277 4 of of IN cord-309161-ceahghs1 277 5 concept concept NN cord-309161-ceahghs1 277 6 trials trial NNS cord-309161-ceahghs1 277 7 related relate VBN cord-309161-ceahghs1 277 8 to to IN cord-309161-ceahghs1 277 9 loss loss NN cord-309161-ceahghs1 277 10 of of IN cord-309161-ceahghs1 277 11 physiological physiological JJ cord-309161-ceahghs1 277 12 resilience resilience NN cord-309161-ceahghs1 277 13 have have VBP cord-309161-ceahghs1 277 14 been be VBN cord-309161-ceahghs1 277 15 initially initially RB cord-309161-ceahghs1 277 16 outlined outline VBN cord-309161-ceahghs1 277 17 ( ( -LRB- cord-309161-ceahghs1 278 1 Justice Justice NNP cord-309161-ceahghs1 278 2 et et NNP cord-309161-ceahghs1 278 3 al al NNP cord-309161-ceahghs1 278 4 . . NNP cord-309161-ceahghs1 278 5 , , , cord-309161-ceahghs1 278 6 2016 2016 CD cord-309161-ceahghs1 278 7 ) ) -RRB- cord-309161-ceahghs1 278 8 , , . cord-309161-ceahghs1 279 1 and and CC cord-309161-ceahghs1 279 2 there there EX cord-309161-ceahghs1 279 3 are be VBP cord-309161-ceahghs1 279 4 many many JJ cord-309161-ceahghs1 279 5 geroscience geroscience NN cord-309161-ceahghs1 279 6 trials trial NNS cord-309161-ceahghs1 279 7 in in IN cord-309161-ceahghs1 279 8 the the DT cord-309161-ceahghs1 279 9 field field NN cord-309161-ceahghs1 279 10 . . . cord-309161-ceahghs1 280 1 These these DT cord-309161-ceahghs1 280 2 human human JJ cord-309161-ceahghs1 280 3 trials trial NNS cord-309161-ceahghs1 280 4 can can MD cord-309161-ceahghs1 280 5 draw draw VB cord-309161-ceahghs1 280 6 on on IN cord-309161-ceahghs1 280 7 the the DT cord-309161-ceahghs1 280 8 rich rich JJ cord-309161-ceahghs1 280 9 insights insight NNS cord-309161-ceahghs1 280 10 from from IN cord-309161-ceahghs1 280 11 decades decade NNS cord-309161-ceahghs1 280 12 of of IN cord-309161-ceahghs1 280 13 biobehavioral biobehavioral JJ cord-309161-ceahghs1 280 14 basic basic JJ cord-309161-ceahghs1 280 15 and and CC cord-309161-ceahghs1 280 16 intervention intervention NN cord-309161-ceahghs1 280 17 research research NN cord-309161-ceahghs1 280 18 . . . cord-309161-ceahghs1 281 1 The the DT cord-309161-ceahghs1 281 2 Science Science NNP cord-309161-ceahghs1 281 3 of of IN cord-309161-ceahghs1 281 4 Behavior Behavior NNP cord-309161-ceahghs1 281 5 Change Change NNP cord-309161-ceahghs1 281 6 initiative initiative NN cord-309161-ceahghs1 281 7 at at IN cord-309161-ceahghs1 281 8 NIH NIH NNP cord-309161-ceahghs1 281 9 is be VBZ cord-309161-ceahghs1 281 10 supporting support VBG cord-309161-ceahghs1 281 11 the the DT cord-309161-ceahghs1 281 12 development development NN cord-309161-ceahghs1 281 13 of of IN cord-309161-ceahghs1 281 14 more more JJR cord-309161-ceahghs1 281 15 effective effective JJ cord-309161-ceahghs1 281 16 behavioral behavioral JJ cord-309161-ceahghs1 281 17 and and CC cord-309161-ceahghs1 281 18 social social JJ cord-309161-ceahghs1 281 19 interventions intervention NNS cord-309161-ceahghs1 281 20 using use VBG cord-309161-ceahghs1 281 21 the the DT cord-309161-ceahghs1 281 22 experimental experimental JJ cord-309161-ceahghs1 281 23 medicine medicine NN cord-309161-ceahghs1 281 24 model model NN cord-309161-ceahghs1 281 25 using use VBG cord-309161-ceahghs1 281 26 the the DT cord-309161-ceahghs1 281 27 same same JJ cord-309161-ceahghs1 281 28 attention attention NN cord-309161-ceahghs1 281 29 and and CC cord-309161-ceahghs1 281 30 rigor rigor NN cord-309161-ceahghs1 281 31 as as IN cord-309161-ceahghs1 281 32 pharmaceutical pharmaceutical JJ cord-309161-ceahghs1 281 33 studies study NNS cord-309161-ceahghs1 281 34 . . . cord-309161-ceahghs1 282 1 By by IN cord-309161-ceahghs1 282 2 working work VBG cord-309161-ceahghs1 282 3 across across IN cord-309161-ceahghs1 282 4 disciplines discipline NNS cord-309161-ceahghs1 282 5 , , , cord-309161-ceahghs1 282 6 with with IN cord-309161-ceahghs1 282 7 an an DT cord-309161-ceahghs1 282 8 understanding understanding NN cord-309161-ceahghs1 282 9 the the DT cord-309161-ceahghs1 282 10 role role NN cord-309161-ceahghs1 282 11 of of IN cord-309161-ceahghs1 282 12 lifespan lifespan NN cord-309161-ceahghs1 282 13 experiences experience NNS cord-309161-ceahghs1 282 14 , , , cord-309161-ceahghs1 282 15 and and CC cord-309161-ceahghs1 282 16 complexity complexity NN cord-309161-ceahghs1 282 17 of of IN cord-309161-ceahghs1 282 18 human human JJ cord-309161-ceahghs1 282 19 environments environment NNS cord-309161-ceahghs1 282 20 , , , cord-309161-ceahghs1 282 21 the the DT cord-309161-ceahghs1 282 22 geroscience geroscience NN cord-309161-ceahghs1 282 23 framework framework NN cord-309161-ceahghs1 282 24 has have VBZ cord-309161-ceahghs1 282 25 tremendous tremendous JJ cord-309161-ceahghs1 282 26 potential potential NN cord-309161-ceahghs1 282 27 for for IN cord-309161-ceahghs1 282 28 breakthrough breakthrough NN cord-309161-ceahghs1 282 29 innovations innovation NNS cord-309161-ceahghs1 282 30 in in IN cord-309161-ceahghs1 282 31 increasing increase VBG cord-309161-ceahghs1 282 32 healthspan healthspan NNP cord-309161-ceahghs1 282 33 . . . cord-309161-ceahghs1 283 1 There there EX cord-309161-ceahghs1 283 2 has have VBZ cord-309161-ceahghs1 283 3 been be VBN cord-309161-ceahghs1 283 4 a a DT cord-309161-ceahghs1 283 5 proliferation proliferation NN cord-309161-ceahghs1 283 6 of of IN cord-309161-ceahghs1 283 7 terms term NNS cord-309161-ceahghs1 283 8 from from IN cord-309161-ceahghs1 283 9 related related JJ cord-309161-ceahghs1 283 10 disciplines discipline NNS cord-309161-ceahghs1 283 11 that that WDT cord-309161-ceahghs1 283 12 overlap overlap VBP cord-309161-ceahghs1 283 13 and and CC cord-309161-ceahghs1 283 14 are be VBP cord-309161-ceahghs1 283 15 differentiated differentiate VBN cord-309161-ceahghs1 283 16 here here RB cord-309161-ceahghs1 283 17 . . . cord-309161-ceahghs1 284 1 The the DT cord-309161-ceahghs1 284 2 discipline discipline NN cord-309161-ceahghs1 284 3 most most RBS cord-309161-ceahghs1 284 4 often often RB cord-309161-ceahghs1 284 5 using use VBG cord-309161-ceahghs1 284 6 the the DT cord-309161-ceahghs1 284 7 term term NN cord-309161-ceahghs1 284 8 is be VBZ cord-309161-ceahghs1 284 9 noted note VBN cord-309161-ceahghs1 284 10 , , , cord-309161-ceahghs1 284 11 but but CC cord-309161-ceahghs1 284 12 these these DT cord-309161-ceahghs1 284 13 terms term NNS cord-309161-ceahghs1 284 14 could could MD cord-309161-ceahghs1 284 15 be be VB cord-309161-ceahghs1 284 16 used use VBN cord-309161-ceahghs1 284 17 to to TO cord-309161-ceahghs1 284 18 describe describe VB cord-309161-ceahghs1 284 19 all all DT cord-309161-ceahghs1 284 20 levels level NNS cord-309161-ceahghs1 284 21 of of IN cord-309161-ceahghs1 284 22 analysis analysis NN cord-309161-ceahghs1 284 23 , , , cord-309161-ceahghs1 284 24 including include VBG cord-309161-ceahghs1 284 25 cellular cellular JJ cord-309161-ceahghs1 284 26 , , , cord-309161-ceahghs1 284 27 physiological physiological JJ cord-309161-ceahghs1 284 28 / / SYM cord-309161-ceahghs1 284 29 organ organ NN cord-309161-ceahghs1 284 30 systems system NNS cord-309161-ceahghs1 284 31 , , , cord-309161-ceahghs1 284 32 or or CC cord-309161-ceahghs1 284 33 psychological psychological JJ cord-309161-ceahghs1 284 34 , , , cord-309161-ceahghs1 284 35 behavioral behavioral JJ cord-309161-ceahghs1 284 36 and and CC cord-309161-ceahghs1 284 37 social social JJ cord-309161-ceahghs1 284 38 processes process NNS cord-309161-ceahghs1 284 39 . . . cord-309161-ceahghs1 285 1 Resilience resilience NN cord-309161-ceahghs1 285 2 has have VBZ cord-309161-ceahghs1 285 3 also also RB cord-309161-ceahghs1 285 4 been be VBN cord-309161-ceahghs1 285 5 applied apply VBN cord-309161-ceahghs1 285 6 ast ast NNP cord-309161-ceahghs1 285 7 the the DT cord-309161-ceahghs1 285 8 systems system NNS cord-309161-ceahghs1 285 9 level level NN cord-309161-ceahghs1 285 10 , , , cord-309161-ceahghs1 285 11 to to IN cord-309161-ceahghs1 285 12 organizations organization NNS cord-309161-ceahghs1 285 13 , , , cord-309161-ceahghs1 285 14 communities community NNS cord-309161-ceahghs1 285 15 , , , cord-309161-ceahghs1 285 16 societies society NNS cord-309161-ceahghs1 285 17 , , , cord-309161-ceahghs1 285 18 and and CC cord-309161-ceahghs1 285 19 ecosystems ecosystem NNS cord-309161-ceahghs1 285 20 . . . cord-309161-ceahghs1 286 1 How how WRB cord-309161-ceahghs1 286 2 systems system NNS cord-309161-ceahghs1 286 3 change change VBP cord-309161-ceahghs1 286 4 in in IN cord-309161-ceahghs1 286 5 response response NN cord-309161-ceahghs1 286 6 to to IN cord-309161-ceahghs1 286 7 stressors stressor NNS cord-309161-ceahghs1 286 8 , , , cord-309161-ceahghs1 286 9 typically typically RB cord-309161-ceahghs1 286 10 referring refer VBG cord-309161-ceahghs1 286 11 to to IN cord-309161-ceahghs1 286 12 level level NN cord-309161-ceahghs1 286 13 of of IN cord-309161-ceahghs1 286 14 hermetic hermetic JJ cord-309161-ceahghs1 286 15 or or CC cord-309161-ceahghs1 286 16 a a DT cord-309161-ceahghs1 286 17 protective protective JJ cord-309161-ceahghs1 286 18 adaptive adaptive JJ cord-309161-ceahghs1 286 19 responses response NNS cord-309161-ceahghs1 286 20 in in IN cord-309161-ceahghs1 286 21 cell cell NN cord-309161-ceahghs1 286 22 such such JJ cord-309161-ceahghs1 286 23 as as IN cord-309161-ceahghs1 286 24 heat heat NN cord-309161-ceahghs1 286 25 shock shock NN cord-309161-ceahghs1 286 26 protein protein NN cord-309161-ceahghs1 286 27 increases increase NNS cord-309161-ceahghs1 286 28 . . . cord-309161-ceahghs1 287 1 ( ( -LRB- cord-309161-ceahghs1 287 2 Mattson Mattson NNP cord-309161-ceahghs1 287 3 ) ) -RRB- cord-309161-ceahghs1 287 4 . . . cord-309161-ceahghs1 288 1 Mild mild JJ cord-309161-ceahghs1 288 2 stressors stressor NNS cord-309161-ceahghs1 288 3 induce induce VBP cord-309161-ceahghs1 288 4 adaptive adaptive JJ cord-309161-ceahghs1 288 5 capacities capacity NNS cord-309161-ceahghs1 288 6 that that WDT cord-309161-ceahghs1 288 7 protect protect VBP cord-309161-ceahghs1 288 8 an an DT cord-309161-ceahghs1 288 9 organism organism NN cord-309161-ceahghs1 288 10 for for IN cord-309161-ceahghs1 288 11 a a DT cord-309161-ceahghs1 288 12 short short JJ cord-309161-ceahghs1 288 13 while while NN cord-309161-ceahghs1 288 14 from from IN cord-309161-ceahghs1 288 15 future future JJ cord-309161-ceahghs1 288 16 stressors stressor NNS cord-309161-ceahghs1 288 17 and and CC cord-309161-ceahghs1 288 18 may may MD cord-309161-ceahghs1 288 19 improve improve VB cord-309161-ceahghs1 288 20 the the DT cord-309161-ceahghs1 288 21 physiological physiological JJ cord-309161-ceahghs1 288 22 state state NN cord-309161-ceahghs1 288 23 of of IN cord-309161-ceahghs1 288 24 that that DT cord-309161-ceahghs1 288 25 organisms organism NNS cord-309161-ceahghs1 288 26 . . . cord-309161-ceahghs1 289 1 Preconditioning preconditioning NN cord-309161-ceahghs1 289 2 is be VBZ cord-309161-ceahghs1 289 3 a a DT cord-309161-ceahghs1 289 4 case case NN cord-309161-ceahghs1 289 5 of of IN cord-309161-ceahghs1 289 6 hormesis hormesis NN cord-309161-ceahghs1 289 7 where where WRB cord-309161-ceahghs1 289 8 exposure exposure NN cord-309161-ceahghs1 289 9 to to IN cord-309161-ceahghs1 289 10 a a DT cord-309161-ceahghs1 289 11 chemical chemical JJ cord-309161-ceahghs1 289 12 agent agent NN cord-309161-ceahghs1 289 13 leads lead VBZ cord-309161-ceahghs1 289 14 to to IN cord-309161-ceahghs1 289 15 a a DT cord-309161-ceahghs1 289 16 30 30 CD cord-309161-ceahghs1 289 17 - - SYM cord-309161-ceahghs1 289 18 60 60 CD cord-309161-ceahghs1 289 19 % % NN cord-309161-ceahghs1 289 20 stronger strong JJR cord-309161-ceahghs1 289 21 adaptive adaptive JJ cord-309161-ceahghs1 289 22 response response NN cord-309161-ceahghs1 289 23 to to IN cord-309161-ceahghs1 289 24 subsequent subsequent JJ cord-309161-ceahghs1 289 25 exposures exposure NNS cord-309161-ceahghs1 289 26 , , , cord-309161-ceahghs1 289 27 across across IN cord-309161-ceahghs1 289 28 cell cell NN cord-309161-ceahghs1 289 29 types type NNS cord-309161-ceahghs1 289 30 and and CC cord-309161-ceahghs1 289 31 stressors stressor NNS cord-309161-ceahghs1 289 32 ( ( -LRB- cord-309161-ceahghs1 289 33 Calabrese Calabrese NNP cord-309161-ceahghs1 289 34 , , , cord-309161-ceahghs1 289 35 201 201 CD cord-309161-ceahghs1 289 36 ) ) -RRB- cord-309161-ceahghs1 289 37 . . . cord-309161-ceahghs1 290 1 In in IN cord-309161-ceahghs1 290 2 psychology psychology NN cord-309161-ceahghs1 290 3 , , , cord-309161-ceahghs1 290 4 the the DT cord-309161-ceahghs1 290 5 tem tem NN cord-309161-ceahghs1 290 6 ' ' POS cord-309161-ceahghs1 290 7 stress stress NN cord-309161-ceahghs1 290 8 inoculation inoculation NN cord-309161-ceahghs1 290 9 ' ' '' cord-309161-ceahghs1 290 10 is be VBZ cord-309161-ceahghs1 290 11 used use VBN cord-309161-ceahghs1 290 12 in in IN cord-309161-ceahghs1 290 13 a a DT cord-309161-ceahghs1 290 14 similar similar JJ cord-309161-ceahghs1 290 15 way way NN cord-309161-ceahghs1 290 16 . . . cord-309161-ceahghs1 291 1 In in IN cord-309161-ceahghs1 291 2 terms term NNS cord-309161-ceahghs1 291 3 of of IN cord-309161-ceahghs1 291 4 psychological psychological JJ cord-309161-ceahghs1 291 5 stressors stressor NNS cord-309161-ceahghs1 291 6 , , , cord-309161-ceahghs1 291 7 under under IN cord-309161-ceahghs1 291 8 - - HYPH cord-309161-ceahghs1 291 9 exposure exposure NN cord-309161-ceahghs1 291 10 to to IN cord-309161-ceahghs1 291 11 the the DT cord-309161-ceahghs1 291 12 typical typical JJ cord-309161-ceahghs1 291 13 daily daily JJ cord-309161-ceahghs1 291 14 and and CC cord-309161-ceahghs1 291 15 major major JJ cord-309161-ceahghs1 291 16 life life NN cord-309161-ceahghs1 291 17 events event NNS cord-309161-ceahghs1 291 18 can can MD cord-309161-ceahghs1 291 19 lead lead VB cord-309161-ceahghs1 291 20 to to IN cord-309161-ceahghs1 291 21 lack lack NN cord-309161-ceahghs1 291 22 of of IN cord-309161-ceahghs1 291 23 development development NN cord-309161-ceahghs1 291 24 of of IN cord-309161-ceahghs1 291 25 stress stress NN cord-309161-ceahghs1 291 26 buffering buffering NN cord-309161-ceahghs1 291 27 resources resource NNS cord-309161-ceahghs1 291 28 , , , cord-309161-ceahghs1 291 29 and and CC cord-309161-ceahghs1 291 30 poor poor JJ cord-309161-ceahghs1 291 31 ability ability NN cord-309161-ceahghs1 291 32 to to TO cord-309161-ceahghs1 291 33 quickly quickly RB cord-309161-ceahghs1 291 34 recover recover VB cord-309161-ceahghs1 291 35 from from IN cord-309161-ceahghs1 291 36 stressors stressor NNS cord-309161-ceahghs1 291 37 . . . cord-309161-ceahghs1 292 1 Biologically biologically RB cord-309161-ceahghs1 292 2 the the DT cord-309161-ceahghs1 292 3 lack lack NN cord-309161-ceahghs1 292 4 of of IN cord-309161-ceahghs1 292 5 acute acute JJ cord-309161-ceahghs1 292 6 stressors stressor NNS cord-309161-ceahghs1 292 7 prevents prevent VBZ cord-309161-ceahghs1 292 8 the the DT cord-309161-ceahghs1 292 9 intermittent intermittent JJ cord-309161-ceahghs1 292 10 episodes episode NNS cord-309161-ceahghs1 292 11 of of IN cord-309161-ceahghs1 292 12 cellular cellular JJ cord-309161-ceahghs1 292 13 ' ' `` cord-309161-ceahghs1 292 14 housecleaning housecleaning NN cord-309161-ceahghs1 292 15 ' ' '' cord-309161-ceahghs1 292 16 activities activity NNS cord-309161-ceahghs1 292 17 that that WDT cord-309161-ceahghs1 292 18 slow slow VBP cord-309161-ceahghs1 292 19 aging aging NN cord-309161-ceahghs1 292 20 . . . cord-309161-ceahghs1 293 1 Ideal ideal JJ cord-309161-ceahghs1 293 2 exposure exposure NN cord-309161-ceahghs1 293 3 to to IN cord-309161-ceahghs1 293 4 sufficient sufficient JJ cord-309161-ceahghs1 293 5 numbers number NNS cord-309161-ceahghs1 293 6 of of IN cord-309161-ceahghs1 293 7 manageable manageable JJ cord-309161-ceahghs1 293 8 challenges challenge NNS cord-309161-ceahghs1 293 9 throughout throughout IN cord-309161-ceahghs1 293 10 life life NN cord-309161-ceahghs1 293 11 stimulate stimulate VBP cord-309161-ceahghs1 293 12 cognitive cognitive JJ cord-309161-ceahghs1 293 13 growth growth NN cord-309161-ceahghs1 293 14 , , , cord-309161-ceahghs1 293 15 coping cope VBG cord-309161-ceahghs1 293 16 skills skill NNS cord-309161-ceahghs1 293 17 , , , cord-309161-ceahghs1 293 18 and and CC cord-309161-ceahghs1 293 19 emotion emotion NN cord-309161-ceahghs1 293 20 regulation regulation NN cord-309161-ceahghs1 293 21 skills skill NNS cord-309161-ceahghs1 293 22 , , , cord-309161-ceahghs1 293 23 as as RB cord-309161-ceahghs1 293 24 well well RB cord-309161-ceahghs1 293 25 as as IN cord-309161-ceahghs1 293 26 the the DT cord-309161-ceahghs1 293 27 need need NN cord-309161-ceahghs1 293 28 for for IN cord-309161-ceahghs1 293 29 supportive supportive JJ cord-309161-ceahghs1 293 30 social social JJ cord-309161-ceahghs1 293 31 networks network NNS cord-309161-ceahghs1 293 32 . . . cord-309161-ceahghs1 294 1 Biologically biologically RB cord-309161-ceahghs1 294 2 , , , cord-309161-ceahghs1 294 3 ideal ideal JJ cord-309161-ceahghs1 294 4 exposure exposure NN cord-309161-ceahghs1 294 5 to to IN cord-309161-ceahghs1 294 6 acute acute JJ cord-309161-ceahghs1 294 7 stress stress NN cord-309161-ceahghs1 294 8 can can MD cord-309161-ceahghs1 294 9 have have VB cord-309161-ceahghs1 294 10 hormetic hormetic JJ cord-309161-ceahghs1 294 11 effects effect NNS cord-309161-ceahghs1 294 12 , , , cord-309161-ceahghs1 294 13 leading lead VBG cord-309161-ceahghs1 294 14 to to IN cord-309161-ceahghs1 294 15 rejuvenescence rejuvenescence NN cord-309161-ceahghs1 294 16 - - HYPH cord-309161-ceahghs1 294 17 functioning functioning NN cord-309161-ceahghs1 294 18 that that WDT cord-309161-ceahghs1 294 19 is be VBZ cord-309161-ceahghs1 294 20 enhanced enhance VBN cord-309161-ceahghs1 294 21 ( ( -LRB- cord-309161-ceahghs1 294 22 or or CC cord-309161-ceahghs1 294 23 " " `` cord-309161-ceahghs1 294 24 younger young JJR cord-309161-ceahghs1 294 25 " " '' cord-309161-ceahghs1 294 26 ) ) -RRB- cord-309161-ceahghs1 294 27 compared compare VBN cord-309161-ceahghs1 294 28 to to IN cord-309161-ceahghs1 294 29 baseline baseline NN cord-309161-ceahghs1 294 30 . . . cord-309161-ceahghs1 295 1 Overexposure overexposure NN cord-309161-ceahghs1 295 2 to to TO cord-309161-ceahghs1 295 3 stress stress NN cord-309161-ceahghs1 295 4 without without IN cord-309161-ceahghs1 295 5 sufficient sufficient JJ cord-309161-ceahghs1 295 6 resources resource NNS cord-309161-ceahghs1 295 7 ( ( -LRB- cord-309161-ceahghs1 295 8 toxic toxic JJ cord-309161-ceahghs1 295 9 stress stress NN cord-309161-ceahghs1 295 10 ) ) -RRB- cord-309161-ceahghs1 295 11 can can MD cord-309161-ceahghs1 295 12 lead lead VB cord-309161-ceahghs1 295 13 to to IN cord-309161-ceahghs1 295 14 maladaptive maladaptive JJ cord-309161-ceahghs1 295 15 neural neural JJ cord-309161-ceahghs1 295 16 pathways pathway NNS cord-309161-ceahghs1 295 17 of of IN cord-309161-ceahghs1 295 18 overresponding overresponde VBG cord-309161-ceahghs1 295 19 to to IN cord-309161-ceahghs1 295 20 stress stress NN cord-309161-ceahghs1 295 21 , , , cord-309161-ceahghs1 295 22 depression depression NN cord-309161-ceahghs1 295 23 , , , cord-309161-ceahghs1 295 24 and and CC cord-309161-ceahghs1 295 25 stress stress NN cord-309161-ceahghs1 295 26 related relate VBN cord-309161-ceahghs1 295 27 acceleration acceleration NN cord-309161-ceahghs1 295 28 of of IN cord-309161-ceahghs1 295 29 aging age VBG cord-309161-ceahghs1 295 30 from from IN cord-309161-ceahghs1 295 31 cells cell NNS cord-309161-ceahghs1 295 32 to to IN cord-309161-ceahghs1 295 33 regulatory regulatory JJ cord-309161-ceahghs1 295 34 systems system NNS cord-309161-ceahghs1 295 35 . . . cord-309161-ceahghs1 296 1 This this DT cord-309161-ceahghs1 296 2 figure figure NN cord-309161-ceahghs1 296 3 is be VBZ cord-309161-ceahghs1 296 4 adapted adapt VBN cord-309161-ceahghs1 296 5 from from IN cord-309161-ceahghs1 296 6 Francheschi Francheschi NNP cord-309161-ceahghs1 296 7 et et NNP cord-309161-ceahghs1 296 8 al al NNP cord-309161-ceahghs1 296 9 , , , cord-309161-ceahghs1 296 10 2018 2018 CD cord-309161-ceahghs1 296 11 . . . cord-309161-ceahghs1 296 12 _SP cord-309161-ceahghs1 297 1 In in IN cord-309161-ceahghs1 297 2 response response NN cord-309161-ceahghs1 297 3 to to IN cord-309161-ceahghs1 297 4 acute acute JJ cord-309161-ceahghs1 297 5 stressors stressor NNS cord-309161-ceahghs1 297 6 , , , cord-309161-ceahghs1 297 7 individuals individual NNS cord-309161-ceahghs1 297 8 have have VBP cord-309161-ceahghs1 297 9 a a DT cord-309161-ceahghs1 297 10 kinetic kinetic JJ cord-309161-ceahghs1 297 11 trajectory trajectory NN cord-309161-ceahghs1 297 12 of of IN cord-309161-ceahghs1 297 13 responses response NNS cord-309161-ceahghs1 297 14 across across IN cord-309161-ceahghs1 297 15 psychological psychological JJ cord-309161-ceahghs1 297 16 and and CC cord-309161-ceahghs1 297 17 physiological physiological JJ cord-309161-ceahghs1 297 18 regulatory regulatory JJ cord-309161-ceahghs1 297 19 systems system NNS cord-309161-ceahghs1 297 20 that that WDT cord-309161-ceahghs1 297 21 lead lead VBP cord-309161-ceahghs1 297 22 to to IN cord-309161-ceahghs1 297 23 reactivity reactivity NN cord-309161-ceahghs1 297 24 and and CC cord-309161-ceahghs1 297 25 recovery recovery NN cord-309161-ceahghs1 297 26 profiles profile NNS cord-309161-ceahghs1 297 27 . . . cord-309161-ceahghs1 298 1 Resilient resilient JJ cord-309161-ceahghs1 298 2 stress stress NN cord-309161-ceahghs1 298 3 responses response NNS cord-309161-ceahghs1 298 4 ( ( -LRB- cord-309161-ceahghs1 298 5 typically typically RB cord-309161-ceahghs1 298 6 rapid rapid JJ cord-309161-ceahghs1 298 7 high high JJ cord-309161-ceahghs1 298 8 peak peak NN cord-309161-ceahghs1 298 9 and and CC cord-309161-ceahghs1 298 10 rapid rapid JJ cord-309161-ceahghs1 298 11 recovery recovery NN cord-309161-ceahghs1 298 12 ) ) -RRB- cord-309161-ceahghs1 298 13 often often RB cord-309161-ceahghs1 298 14 have have VBP cord-309161-ceahghs1 298 15 hormetic hormetic JJ cord-309161-ceahghs1 298 16 effects effect NNS cord-309161-ceahghs1 298 17 at at IN cord-309161-ceahghs1 298 18 the the DT cord-309161-ceahghs1 298 19 cellular cellular JJ cord-309161-ceahghs1 298 20 or or CC cord-309161-ceahghs1 298 21 systemic systemic JJ cord-309161-ceahghs1 298 22 levels level NNS cord-309161-ceahghs1 298 23 . . . cord-309161-ceahghs1 299 1 High high JJ cord-309161-ceahghs1 299 2 levels level NNS cord-309161-ceahghs1 299 3 of of IN cord-309161-ceahghs1 299 4 reserve reserve NN cord-309161-ceahghs1 299 5 capacity capacity NN cord-309161-ceahghs1 299 6 predict predict VBP cord-309161-ceahghs1 299 7 more more RBR cord-309161-ceahghs1 299 8 rapid rapid JJ cord-309161-ceahghs1 299 9 recovery recovery NN cord-309161-ceahghs1 299 10 , , , cord-309161-ceahghs1 299 11 and and CC cord-309161-ceahghs1 299 12 this this DT cord-309161-ceahghs1 299 13 may may MD cord-309161-ceahghs1 299 14 lead lead VB cord-309161-ceahghs1 299 15 to to IN cord-309161-ceahghs1 299 16 a a DT cord-309161-ceahghs1 299 17 positive positive JJ cord-309161-ceahghs1 299 18 feedback feedback NN cord-309161-ceahghs1 299 19 loop loop NN cord-309161-ceahghs1 299 20 promoting promote VBG cord-309161-ceahghs1 299 21 higher high JJR cord-309161-ceahghs1 299 22 reserve reserve NN cord-309161-ceahghs1 299 23 capacity capacity NN cord-309161-ceahghs1 299 24 . . . cord-309161-ceahghs1 300 1 Level level NN cord-309161-ceahghs1 300 2 of of IN cord-309161-ceahghs1 300 3 stress stress NN cord-309161-ceahghs1 300 4 resilience resilience NN cord-309161-ceahghs1 300 5 is be VBZ cord-309161-ceahghs1 300 6 multiply multiply VB cord-309161-ceahghs1 300 7 determined determine VBN cord-309161-ceahghs1 300 8 by by IN cord-309161-ceahghs1 300 9 the the DT cord-309161-ceahghs1 300 10 social social JJ cord-309161-ceahghs1 300 11 context context NN cord-309161-ceahghs1 300 12 and and CC cord-309161-ceahghs1 300 13 individual individual JJ cord-309161-ceahghs1 300 14 reserve reserve NN cord-309161-ceahghs1 300 15 capacity capacity NN cord-309161-ceahghs1 300 16 . . . cord-309161-ceahghs1 301 1 Together together RB cord-309161-ceahghs1 301 2 the the DT cord-309161-ceahghs1 301 3 latent latent JJ cord-309161-ceahghs1 301 4 homeostatic homeostatic JJ cord-309161-ceahghs1 301 5 capacity capacity NN cord-309161-ceahghs1 301 6 of of IN cord-309161-ceahghs1 301 7 the the DT cord-309161-ceahghs1 301 8 organism organism NN cord-309161-ceahghs1 301 9 to to TO cord-309161-ceahghs1 301 10 have have VB cord-309161-ceahghs1 301 11 resilient resilient JJ cord-309161-ceahghs1 301 12 stress stress NN cord-309161-ceahghs1 301 13 responses response NNS cord-309161-ceahghs1 301 14 serves serve VBZ cord-309161-ceahghs1 301 15 as as IN cord-309161-ceahghs1 301 16 an an DT cord-309161-ceahghs1 301 17 indicator indicator NN cord-309161-ceahghs1 301 18 of of IN cord-309161-ceahghs1 301 19 biological biological JJ cord-309161-ceahghs1 301 20 age age NN cord-309161-ceahghs1 301 21 and and CC cord-309161-ceahghs1 301 22 over over IN cord-309161-ceahghs1 301 23 time time NN cord-309161-ceahghs1 301 24 may may MD cord-309161-ceahghs1 301 25 influence influence VB cord-309161-ceahghs1 301 26 the the DT cord-309161-ceahghs1 301 27 speed speed NN cord-309161-ceahghs1 301 28 of of IN cord-309161-ceahghs1 301 29 aging aging NN cord-309161-ceahghs1 301 30 . . . cord-309161-ceahghs1 301 31 _SP cord-309161-ceahghs1 302 1 Assessment Assessment NNP cord-309161-ceahghs1 302 2 of of IN cord-309161-ceahghs1 302 3 Community Community NNP cord-309161-ceahghs1 302 4 - - HYPH cord-309161-ceahghs1 302 5 Level Level NNP cord-309161-ceahghs1 302 6 Disparities Disparities NNPS cord-309161-ceahghs1 302 7 in in IN cord-309161-ceahghs1 302 8 Coronavirus Coronavirus NNP cord-309161-ceahghs1 302 9 Disease Disease NNP cord-309161-ceahghs1 302 10 2019 2019 CD cord-309161-ceahghs1 303 1 ( ( -LRB- cord-309161-ceahghs1 303 2 COVID-19 COVID-19 NNP cord-309161-ceahghs1 303 3 ) ) -RRB- cord-309161-ceahghs1 303 4 Infections Infections NNPS cord-309161-ceahghs1 303 5 and and CC cord-309161-ceahghs1 303 6 Deaths death NNS cord-309161-ceahghs1 303 7 in in IN cord-309161-ceahghs1 303 8 Large large JJ cord-309161-ceahghs1 303 9 US US NNP cord-309161-ceahghs1 303 10 Metropolitan Metropolitan NNP cord-309161-ceahghs1 303 11 Areas Areas NNPS cord-309161-ceahghs1 304 1 Socioeconomic socioeconomic JJ cord-309161-ceahghs1 304 2 inequalities inequality NNS cord-309161-ceahghs1 304 3 in in IN cord-309161-ceahghs1 304 4 health health NN cord-309161-ceahghs1 304 5 . . . cord-309161-ceahghs1 305 1 No no DT cord-309161-ceahghs1 305 2 easy easy JJ cord-309161-ceahghs1 305 3 solution solution NN cord-309161-ceahghs1 305 4 Early early JJ cord-309161-ceahghs1 305 5 life life NN cord-309161-ceahghs1 305 6 stress stress NN cord-309161-ceahghs1 305 7 and and CC cord-309161-ceahghs1 305 8 trauma trauma NN cord-309161-ceahghs1 305 9 : : : cord-309161-ceahghs1 306 1 Developmental developmental JJ cord-309161-ceahghs1 306 2 neuroendocrine neuroendocrine JJ cord-309161-ceahghs1 306 3 aspects aspect NNS cord-309161-ceahghs1 306 4 of of IN cord-309161-ceahghs1 306 5 prolonged prolonged JJ cord-309161-ceahghs1 306 6 stress stress NN cord-309161-ceahghs1 306 7 system system NN cord-309161-ceahghs1 306 8 dysregulation dysregulation NN cord-309161-ceahghs1 307 1 Psychological psychological JJ cord-309161-ceahghs1 307 2 Impacts impact NNS cord-309161-ceahghs1 307 3 of of IN cord-309161-ceahghs1 307 4 the the DT cord-309161-ceahghs1 307 5 COVID-19 COVID-19 NNP cord-309161-ceahghs1 307 6 Pandemic Pandemic NNP cord-309161-ceahghs1 307 7 on on IN cord-309161-ceahghs1 307 8 the the DT cord-309161-ceahghs1 307 9 Public Public NNP cord-309161-ceahghs1 307 10 in in IN cord-309161-ceahghs1 307 11 Egypt Egypt NNP cord-309161-ceahghs1 308 1 A a DT cord-309161-ceahghs1 308 2 Systematic Systematic NNP cord-309161-ceahghs1 308 3 Review Review NNP cord-309161-ceahghs1 308 4 and and CC cord-309161-ceahghs1 308 5 Metaanalysis Metaanalysis NNP cord-309161-ceahghs1 308 6 of of IN cord-309161-ceahghs1 308 7 Depression Depression NNP cord-309161-ceahghs1 308 8 , , , cord-309161-ceahghs1 308 9 Anxiety Anxiety NNP cord-309161-ceahghs1 308 10 , , , cord-309161-ceahghs1 308 11 and and CC cord-309161-ceahghs1 308 12 Sleep Sleep NNP cord-309161-ceahghs1 308 13 Disorders disorder NNS cord-309161-ceahghs1 308 14 in in IN cord-309161-ceahghs1 308 15 US US NNP cord-309161-ceahghs1 308 16 Adults Adults NNPS cord-309161-ceahghs1 308 17 with with IN cord-309161-ceahghs1 308 18 Food Food NNP cord-309161-ceahghs1 308 19 Insecurity Insecurity NNP cord-309161-ceahghs1 308 20 Ischemic ischemic JJ cord-309161-ceahghs1 308 21 preconditioning preconditioning NN cord-309161-ceahghs1 308 22 improves improve VBZ cord-309161-ceahghs1 308 23 performance performance NN cord-309161-ceahghs1 308 24 and and CC cord-309161-ceahghs1 308 25 accelerates accelerate VBZ cord-309161-ceahghs1 308 26 the the DT cord-309161-ceahghs1 308 27 heart heart NN cord-309161-ceahghs1 308 28 rate rate NN cord-309161-ceahghs1 308 29 recovery recovery NN cord-309161-ceahghs1 309 1 The the DT cord-309161-ceahghs1 309 2 Geroscience Geroscience NNP cord-309161-ceahghs1 309 3 Hypothesis Hypothesis NNP cord-309161-ceahghs1 309 4 : : : cord-309161-ceahghs1 309 5 Is be VBZ cord-309161-ceahghs1 309 6 It -PRON- PRP cord-309161-ceahghs1 309 7 Possible possible JJ cord-309161-ceahghs1 309 8 to to TO cord-309161-ceahghs1 309 9 Change change VB cord-309161-ceahghs1 309 10 the the DT cord-309161-ceahghs1 309 11 Rate rate NN cord-309161-ceahghs1 309 12 of of IN cord-309161-ceahghs1 309 13 Aging age VBG cord-309161-ceahghs1 309 14 ? ? . cord-309161-ceahghs1 310 1 Telomeres telomere NNS cord-309161-ceahghs1 310 2 and and CC cord-309161-ceahghs1 310 3 COVID-19 COVID-19 NNP cord-309161-ceahghs1 310 4 Early early JJ cord-309161-ceahghs1 310 5 and and CC cord-309161-ceahghs1 310 6 late late JJ cord-309161-ceahghs1 310 7 childhood childhood NN cord-309161-ceahghs1 310 8 telomere telomere NN cord-309161-ceahghs1 310 9 length length NN cord-309161-ceahghs1 310 10 predict predict VBP cord-309161-ceahghs1 310 11 subclinical subclinical JJ cord-309161-ceahghs1 310 12 atherosclerosis atherosclerosis NN cord-309161-ceahghs1 310 13 at at IN cord-309161-ceahghs1 310 14 age age NN cord-309161-ceahghs1 310 15 14 14 CD cord-309161-ceahghs1 310 16 yrs yr NNS cord-309161-ceahghs1 310 17 . . . cord-309161-ceahghs1 311 1 -The -The . cord-309161-ceahghs1 312 1 CardioCAPS cardiocaps CD cord-309161-ceahghs1 312 2 study study NN cord-309161-ceahghs1 312 3 Geroscience Geroscience NNP cord-309161-ceahghs1 312 4 in in IN cord-309161-ceahghs1 312 5 the the DT cord-309161-ceahghs1 312 6 Age Age NNP cord-309161-ceahghs1 312 7 of of IN cord-309161-ceahghs1 312 8 COVID-19 COVID-19 NNP cord-309161-ceahghs1 312 9 TARGETING targeting JJ cord-309161-ceahghs1 312 10 AGING age VBG cord-309161-ceahghs1 312 11 WITH with IN cord-309161-ceahghs1 312 12 METFORMIN METFORMIN NNP cord-309161-ceahghs1 312 13 ( ( -LRB- cord-309161-ceahghs1 312 14 TAME TAME NNP cord-309161-ceahghs1 312 15 ) ) -RRB- cord-309161-ceahghs1 313 1 Critical critical JJ cord-309161-ceahghs1 313 2 features feature NNS cord-309161-ceahghs1 313 3 of of IN cord-309161-ceahghs1 313 4 acute acute JJ cord-309161-ceahghs1 313 5 stress stress NN cord-309161-ceahghs1 313 6 - - HYPH cord-309161-ceahghs1 313 7 induced induce VBN cord-309161-ceahghs1 313 8 crosssensitization crosssensitization NN cord-309161-ceahghs1 313 9 identified identify VBN cord-309161-ceahghs1 313 10 through through IN cord-309161-ceahghs1 313 11 the the DT cord-309161-ceahghs1 313 12 hypothalamic hypothalamic JJ cord-309161-ceahghs1 313 13 - - HYPH cord-309161-ceahghs1 313 14 pituitary pituitary NN cord-309161-ceahghs1 313 15 - - HYPH cord-309161-ceahghs1 313 16 adrenal adrenal JJ cord-309161-ceahghs1 313 17 axis axis NN cord-309161-ceahghs1 313 18 output output NN cord-309161-ceahghs1 313 19 Impact impact NN cord-309161-ceahghs1 313 20 of of IN cord-309161-ceahghs1 313 21 early early JJ cord-309161-ceahghs1 313 22 personal personal JJ cord-309161-ceahghs1 313 23 - - HYPH cord-309161-ceahghs1 313 24 history history NN cord-309161-ceahghs1 313 25 characteristics characteristic NNS cord-309161-ceahghs1 313 26 on on IN cord-309161-ceahghs1 313 27 the the DT cord-309161-ceahghs1 313 28 Pace Pace NNP cord-309161-ceahghs1 313 29 of of IN cord-309161-ceahghs1 313 30 Aging age VBG cord-309161-ceahghs1 313 31 : : : cord-309161-ceahghs1 313 32 Implications implication NNS cord-309161-ceahghs1 313 33 for for IN cord-309161-ceahghs1 313 34 clinical clinical JJ cord-309161-ceahghs1 313 35 trials trial NNS cord-309161-ceahghs1 313 36 of of IN cord-309161-ceahghs1 313 37 therapies therapy NNS cord-309161-ceahghs1 313 38 to to TO cord-309161-ceahghs1 313 39 slow slow VB cord-309161-ceahghs1 313 40 aging aging NN cord-309161-ceahghs1 313 41 and and CC cord-309161-ceahghs1 313 42 extend extend VB cord-309161-ceahghs1 313 43 healthspan healthspan NNP cord-309161-ceahghs1 313 44 Change change NN cord-309161-ceahghs1 313 45 in in IN cord-309161-ceahghs1 313 46 the the DT cord-309161-ceahghs1 313 47 Rate rate NN cord-309161-ceahghs1 313 48 of of IN cord-309161-ceahghs1 313 49 Biological Biological NNP cord-309161-ceahghs1 313 50 Aging age VBG cord-309161-ceahghs1 313 51 in in IN cord-309161-ceahghs1 313 52 Response response NN cord-309161-ceahghs1 313 53 to to IN cord-309161-ceahghs1 313 54 Caloric Caloric NNP cord-309161-ceahghs1 313 55 Restriction Restriction NNP cord-309161-ceahghs1 313 56 : : : cord-309161-ceahghs1 313 57 CALERIE CALERIE NNP cord-309161-ceahghs1 313 58 Biobank Biobank NNP cord-309161-ceahghs1 313 59 Analysis Analysis NNP cord-309161-ceahghs1 313 60 Mind mind NN cord-309161-ceahghs1 313 61 - - HYPH cord-309161-ceahghs1 313 62 body body NN cord-309161-ceahghs1 313 63 therapies therapy NNS cord-309161-ceahghs1 313 64 and and CC cord-309161-ceahghs1 313 65 control control NN cord-309161-ceahghs1 313 66 of of IN cord-309161-ceahghs1 313 67 inflammatory inflammatory JJ cord-309161-ceahghs1 313 68 biology biology NN cord-309161-ceahghs1 313 69 : : : cord-309161-ceahghs1 314 1 A a DT cord-309161-ceahghs1 314 2 descriptive descriptive JJ cord-309161-ceahghs1 314 3 review review NN cord-309161-ceahghs1 315 1 A a DT cord-309161-ceahghs1 315 2 Systematic Systematic NNP cord-309161-ceahghs1 315 3 Review Review NNP cord-309161-ceahghs1 315 4 of of IN cord-309161-ceahghs1 315 5 the the DT cord-309161-ceahghs1 315 6 Association Association NNP cord-309161-ceahghs1 315 7 between between IN cord-309161-ceahghs1 315 8 Poverty Poverty NNP cord-309161-ceahghs1 315 9 and and CC cord-309161-ceahghs1 315 10 Biomarkers Biomarkers NNPS cord-309161-ceahghs1 315 11 of of IN cord-309161-ceahghs1 315 12 Toxic toxic JJ cord-309161-ceahghs1 315 13 Stress stress NN cord-309161-ceahghs1 315 14 Exposed expose VBN cord-309161-ceahghs1 315 15 to to IN cord-309161-ceahghs1 315 16 events event NNS cord-309161-ceahghs1 315 17 that that WDT cord-309161-ceahghs1 315 18 never never RB cord-309161-ceahghs1 315 19 happen happen VBP cord-309161-ceahghs1 315 20 : : : cord-309161-ceahghs1 315 21 Generalized generalized JJ cord-309161-ceahghs1 315 22 unsafety unsafety NN cord-309161-ceahghs1 315 23 , , , cord-309161-ceahghs1 315 24 the the DT cord-309161-ceahghs1 315 25 default default NN cord-309161-ceahghs1 315 26 stress stress NN cord-309161-ceahghs1 315 27 response response NN cord-309161-ceahghs1 315 28 , , , cord-309161-ceahghs1 315 29 and and CC cord-309161-ceahghs1 315 30 prolonged prolonged JJ cord-309161-ceahghs1 315 31 autonomic autonomic JJ cord-309161-ceahghs1 315 32 activity activity NN cord-309161-ceahghs1 315 33 Social social JJ cord-309161-ceahghs1 315 34 regulation regulation NN cord-309161-ceahghs1 315 35 of of IN cord-309161-ceahghs1 315 36 inflammation inflammation NN cord-309161-ceahghs1 315 37 related relate VBN cord-309161-ceahghs1 315 38 gene gene NN cord-309161-ceahghs1 315 39 expression expression NN cord-309161-ceahghs1 315 40 in in IN cord-309161-ceahghs1 315 41 the the DT cord-309161-ceahghs1 315 42 multi multi JJ cord-309161-ceahghs1 315 43 - - JJ cord-309161-ceahghs1 315 44 ethnic ethnic JJ cord-309161-ceahghs1 315 45 study study NN cord-309161-ceahghs1 315 46 of of IN cord-309161-ceahghs1 315 47 atherosclerosis atherosclerosis NN cord-309161-ceahghs1 316 1 The the DT cord-309161-ceahghs1 316 2 effects effect NNS cord-309161-ceahghs1 316 3 of of IN cord-309161-ceahghs1 316 4 gamma gamma NN cord-309161-ceahghs1 316 5 rays ray NNS cord-309161-ceahghs1 316 6 on on IN cord-309161-ceahghs1 316 7 longevity longevity NN cord-309161-ceahghs1 316 8 Stress Stress NNP cord-309161-ceahghs1 316 9 Biology Biology NNP cord-309161-ceahghs1 316 10 and and CC cord-309161-ceahghs1 316 11 Hormesis Hormesis NNP cord-309161-ceahghs1 316 12 : : : cord-309161-ceahghs1 316 13 The the DT cord-309161-ceahghs1 316 14 Yerkes Yerkes NNP cord-309161-ceahghs1 316 15 - - HYPH cord-309161-ceahghs1 316 16 Dodson Dodson NNP cord-309161-ceahghs1 316 17 Law Law NNP cord-309161-ceahghs1 316 18 in in IN cord-309161-ceahghs1 316 19 Psychology Psychology NNP cord-309161-ceahghs1 316 20 - - HYPH cord-309161-ceahghs1 316 21 A A NNP cord-309161-ceahghs1 316 22 Special Special NNP cord-309161-ceahghs1 316 23 Case case NN cord-309161-ceahghs1 316 24 of of IN cord-309161-ceahghs1 316 25 the the DT cord-309161-ceahghs1 316 26 Hormesis Hormesis NNP cord-309161-ceahghs1 316 27 Dose Dose NNP cord-309161-ceahghs1 316 28 Response response NN cord-309161-ceahghs1 317 1 Preconditioning preconditioning NN cord-309161-ceahghs1 317 2 is be VBZ cord-309161-ceahghs1 317 3 hormesis hormesis NN cord-309161-ceahghs1 317 4 part part NN cord-309161-ceahghs1 318 1 I -PRON- PRP cord-309161-ceahghs1 318 2 : : : cord-309161-ceahghs1 318 3 Documentation documentation NN cord-309161-ceahghs1 318 4 , , , cord-309161-ceahghs1 318 5 dose dose NN cord-309161-ceahghs1 318 6 - - HYPH cord-309161-ceahghs1 318 7 response response NN cord-309161-ceahghs1 318 8 features feature NNS cord-309161-ceahghs1 318 9 and and CC cord-309161-ceahghs1 318 10 mechanistic mechanistic JJ cord-309161-ceahghs1 318 11 foundations foundation NNS cord-309161-ceahghs1 319 1 Building build VBG cord-309161-ceahghs1 319 2 Biological Biological NNP cord-309161-ceahghs1 319 3 Shields Shields NNPS cord-309161-ceahghs1 319 4 via via IN cord-309161-ceahghs1 319 5 Hormesis Hormesis NNP cord-309161-ceahghs1 319 6 Sex Sex NNP cord-309161-ceahghs1 319 7 hormonal hormonal JJ cord-309161-ceahghs1 319 8 regulation regulation NN cord-309161-ceahghs1 319 9 and and CC cord-309161-ceahghs1 319 10 hormesis hormesis NN cord-309161-ceahghs1 319 11 in in IN cord-309161-ceahghs1 319 12 aging aging NN cord-309161-ceahghs1 319 13 and and CC cord-309161-ceahghs1 319 14 longevity longevity NN cord-309161-ceahghs1 319 15 : : : cord-309161-ceahghs1 319 16 Role role NN cord-309161-ceahghs1 319 17 of of IN cord-309161-ceahghs1 319 18 vitagenes vitagene NNS cord-309161-ceahghs1 320 1 The the DT cord-309161-ceahghs1 320 2 wisdom wisdom NN cord-309161-ceahghs1 320 3 of of IN cord-309161-ceahghs1 320 4 the the DT cord-309161-ceahghs1 320 5 body body NN cord-309161-ceahghs1 320 6 Impact Impact NNP cord-309161-ceahghs1 320 7 of of IN cord-309161-ceahghs1 320 8 the the DT cord-309161-ceahghs1 320 9 Baltimore Baltimore NNP cord-309161-ceahghs1 320 10 Experience Experience NNP cord-309161-ceahghs1 320 11 Corps Corps NNP cord-309161-ceahghs1 320 12 Trial Trial NNP cord-309161-ceahghs1 320 13 on on IN cord-309161-ceahghs1 320 14 cortical cortical JJ cord-309161-ceahghs1 320 15 and and CC cord-309161-ceahghs1 320 16 hippocampal hippocampal JJ cord-309161-ceahghs1 320 17 volumes volume NNS cord-309161-ceahghs1 320 18 Autonomic Autonomic NNP cord-309161-ceahghs1 320 19 and and CC cord-309161-ceahghs1 320 20 Brain Brain NNP cord-309161-ceahghs1 320 21 Morphological Morphological NNP cord-309161-ceahghs1 320 22 Predictors Predictors NNPS cord-309161-ceahghs1 320 23 of of IN cord-309161-ceahghs1 320 24 Stress Stress NNP cord-309161-ceahghs1 320 25 Resilience Resilience NNP cord-309161-ceahghs1 321 1 The the DT cord-309161-ceahghs1 321 2 contagion contagion NN cord-309161-ceahghs1 321 3 of of IN cord-309161-ceahghs1 321 4 social social JJ cord-309161-ceahghs1 321 5 defeat defeat NN cord-309161-ceahghs1 321 6 stress stress NN cord-309161-ceahghs1 321 7 : : : cord-309161-ceahghs1 321 8 Insights insight NNS cord-309161-ceahghs1 321 9 from from IN cord-309161-ceahghs1 321 10 rodent rodent NN cord-309161-ceahghs1 321 11 studies study NNS cord-309161-ceahghs1 321 12 Neurobiology Neurobiology NNP cord-309161-ceahghs1 321 13 of of IN cord-309161-ceahghs1 321 14 Resilience Resilience NNP cord-309161-ceahghs1 321 15 : : : cord-309161-ceahghs1 321 16 Interface Interface NNP cord-309161-ceahghs1 321 17 Between between IN cord-309161-ceahghs1 321 18 Mind mind NN cord-309161-ceahghs1 321 19 and and CC cord-309161-ceahghs1 321 20 Body body NN cord-309161-ceahghs1 322 1 The the DT cord-309161-ceahghs1 322 2 wear wear NN cord-309161-ceahghs1 322 3 and and CC cord-309161-ceahghs1 322 4 tear tear NN cord-309161-ceahghs1 322 5 of of IN cord-309161-ceahghs1 322 6 daily daily JJ cord-309161-ceahghs1 322 7 stressors stressor NNS cord-309161-ceahghs1 322 8 on on IN cord-309161-ceahghs1 322 9 mental mental JJ cord-309161-ceahghs1 322 10 health health NN cord-309161-ceahghs1 322 11 Social Social NNP cord-309161-ceahghs1 322 12 contagion contagion NN cord-309161-ceahghs1 322 13 theory theory NN cord-309161-ceahghs1 322 14 : : : cord-309161-ceahghs1 322 15 Examining examine VBG cord-309161-ceahghs1 322 16 dynamic dynamic JJ cord-309161-ceahghs1 322 17 social social JJ cord-309161-ceahghs1 322 18 networks network NNS cord-309161-ceahghs1 322 19 and and CC cord-309161-ceahghs1 322 20 human human JJ cord-309161-ceahghs1 322 21 behavior behavior NN cord-309161-ceahghs1 323 1 The the DT cord-309161-ceahghs1 323 2 Cognitive Cognitive NNP cord-309161-ceahghs1 323 3 Reserve Reserve NNP cord-309161-ceahghs1 323 4 Model Model NNP cord-309161-ceahghs1 323 5 in in IN cord-309161-ceahghs1 323 6 the the DT cord-309161-ceahghs1 323 7 Development Development NNP cord-309161-ceahghs1 323 8 of of IN cord-309161-ceahghs1 323 9 Delirium Delirium NNP cord-309161-ceahghs1 323 10 : : : cord-309161-ceahghs1 324 1 The the DT cord-309161-ceahghs1 324 2 Successful successful JJ cord-309161-ceahghs1 324 3 Aging age VBG cord-309161-ceahghs1 324 4 After after IN cord-309161-ceahghs1 324 5 Elective Elective NNP cord-309161-ceahghs1 324 6 Surgery surgery NN cord-309161-ceahghs1 324 7 Study Study NNP cord-309161-ceahghs1 324 8 Types type NNS cord-309161-ceahghs1 324 9 of of IN cord-309161-ceahghs1 324 10 stressors stressor NNS cord-309161-ceahghs1 324 11 that that WDT cord-309161-ceahghs1 324 12 increase increase VBP cord-309161-ceahghs1 324 13 susceptibility susceptibility NN cord-309161-ceahghs1 324 14 to to IN cord-309161-ceahghs1 324 15 the the DT cord-309161-ceahghs1 324 16 common common JJ cord-309161-ceahghs1 324 17 cold cold NN cord-309161-ceahghs1 324 18 in in IN cord-309161-ceahghs1 324 19 healthy healthy JJ cord-309161-ceahghs1 324 20 adults adult NNS cord-309161-ceahghs1 324 21 Psychological psychological JJ cord-309161-ceahghs1 324 22 stress stress NN cord-309161-ceahghs1 324 23 and and CC cord-309161-ceahghs1 324 24 susceptibility susceptibility NN cord-309161-ceahghs1 324 25 to to IN cord-309161-ceahghs1 324 26 the the DT cord-309161-ceahghs1 324 27 common common JJ cord-309161-ceahghs1 324 28 cold cold NNP cord-309161-ceahghs1 324 29 Association Association NNP cord-309161-ceahghs1 324 30 between between IN cord-309161-ceahghs1 324 31 telomere telomere NN cord-309161-ceahghs1 324 32 length length NN cord-309161-ceahghs1 324 33 and and CC cord-309161-ceahghs1 324 34 experimentally experimentally RB cord-309161-ceahghs1 324 35 induced induce VBN cord-309161-ceahghs1 324 36 upper upper JJ cord-309161-ceahghs1 324 37 respiratory respiratory JJ cord-309161-ceahghs1 324 38 viral viral JJ cord-309161-ceahghs1 324 39 infection infection NN cord-309161-ceahghs1 324 40 in in IN cord-309161-ceahghs1 324 41 healthy healthy JJ cord-309161-ceahghs1 324 42 adults adult NNS cord-309161-ceahghs1 325 1 Biological biological JJ cord-309161-ceahghs1 325 2 aging age VBG cord-309161-ceahghs1 325 3 in in IN cord-309161-ceahghs1 325 4 childhood childhood NN cord-309161-ceahghs1 325 5 and and CC cord-309161-ceahghs1 325 6 adolescence adolescence NN cord-309161-ceahghs1 325 7 following follow VBG cord-309161-ceahghs1 325 8 experiences experience NNS cord-309161-ceahghs1 325 9 of of IN cord-309161-ceahghs1 325 10 threat threat NN cord-309161-ceahghs1 325 11 and and CC cord-309161-ceahghs1 325 12 deprivation deprivation NN cord-309161-ceahghs1 325 13 : : : cord-309161-ceahghs1 326 1 A a DT cord-309161-ceahghs1 326 2 systematic systematic JJ cord-309161-ceahghs1 326 3 review review NN cord-309161-ceahghs1 326 4 and and CC cord-309161-ceahghs1 326 5 meta meta NNP cord-309161-ceahghs1 326 6 - - HYPH cord-309161-ceahghs1 326 7 analysis analysis NN cord-309161-ceahghs1 326 8 Resiliency Resiliency NNP cord-309161-ceahghs1 326 9 Groups group NNS cord-309161-ceahghs1 327 1 Following follow VBG cord-309161-ceahghs1 327 2 Hip hip NN cord-309161-ceahghs1 327 3 Fracture Fracture NNP cord-309161-ceahghs1 327 4 in in IN cord-309161-ceahghs1 327 5 Older old JJR cord-309161-ceahghs1 327 6 Adults Adults NNP cord-309161-ceahghs1 327 7 Meditation Meditation NNP cord-309161-ceahghs1 327 8 , , , cord-309161-ceahghs1 327 9 stress stress NN cord-309161-ceahghs1 327 10 processes process NNS cord-309161-ceahghs1 327 11 , , , cord-309161-ceahghs1 327 12 and and CC cord-309161-ceahghs1 327 13 telomere telomere NN cord-309161-ceahghs1 327 14 biology biology NN cord-309161-ceahghs1 327 15 Mindfulness mindfulness NN cord-309161-ceahghs1 327 16 Interventions Interventions NNPS cord-309161-ceahghs1 327 17 Adverse adverse JJ cord-309161-ceahghs1 327 18 childhood childhood NN cord-309161-ceahghs1 327 19 experiences experience NNS cord-309161-ceahghs1 327 20 , , , cord-309161-ceahghs1 327 21 allostasis allostasis NNP cord-309161-ceahghs1 327 22 , , , cord-309161-ceahghs1 327 23 allostatic allostatic JJ cord-309161-ceahghs1 327 24 load load NN cord-309161-ceahghs1 327 25 , , , cord-309161-ceahghs1 327 26 and and CC cord-309161-ceahghs1 327 27 age age NN cord-309161-ceahghs1 327 28 - - HYPH cord-309161-ceahghs1 327 29 related relate VBN cord-309161-ceahghs1 327 30 disease disease NN cord-309161-ceahghs1 327 31 Physical physical JJ cord-309161-ceahghs1 327 32 activity activity NN cord-309161-ceahghs1 327 33 and and CC cord-309161-ceahghs1 327 34 healthy healthy JJ cord-309161-ceahghs1 327 35 ageing ageing NN cord-309161-ceahghs1 327 36 : : : cord-309161-ceahghs1 328 1 A a DT cord-309161-ceahghs1 328 2 systematic systematic JJ cord-309161-ceahghs1 328 3 review review NN cord-309161-ceahghs1 328 4 and and CC cord-309161-ceahghs1 328 5 meta meta NNP cord-309161-ceahghs1 328 6 - - HYPH cord-309161-ceahghs1 328 7 analysis analysis NN cord-309161-ceahghs1 328 8 of of IN cord-309161-ceahghs1 328 9 longitudinal longitudinal JJ cord-309161-ceahghs1 328 10 cohort cohort NN cord-309161-ceahghs1 328 11 studies study NNS cord-309161-ceahghs1 328 12 A A NNP cord-309161-ceahghs1 328 13 Randomized Randomized NNP cord-309161-ceahghs1 328 14 Controlled Controlled NNP cord-309161-ceahghs1 328 15 Trial Trial NNP cord-309161-ceahghs1 328 16 of of IN cord-309161-ceahghs1 328 17 a a DT cord-309161-ceahghs1 328 18 Mindfulness Mindfulness NNP cord-309161-ceahghs1 328 19 - - HYPH cord-309161-ceahghs1 328 20 Based Based NNP cord-309161-ceahghs1 328 21 Weight Weight NNP cord-309161-ceahghs1 328 22 Loss Loss NNP cord-309161-ceahghs1 328 23 Intervention Intervention NNP cord-309161-ceahghs1 328 24 on on IN cord-309161-ceahghs1 328 25 Cardiovascular Cardiovascular NNP cord-309161-ceahghs1 328 26 Reactivity Reactivity NNP cord-309161-ceahghs1 328 27 to to IN cord-309161-ceahghs1 328 28 Social Social NNP cord-309161-ceahghs1 328 29 - - HYPH cord-309161-ceahghs1 328 30 Evaluative evaluative JJ cord-309161-ceahghs1 328 31 Threat threat NN cord-309161-ceahghs1 328 32 Among among IN cord-309161-ceahghs1 328 33 Adults Adults NNPS cord-309161-ceahghs1 328 34 with with IN cord-309161-ceahghs1 328 35 Obesity obesity NN cord-309161-ceahghs1 328 36 Biomarkers Biomarkers NNPS cord-309161-ceahghs1 328 37 of of IN cord-309161-ceahghs1 328 38 adverse adverse JJ cord-309161-ceahghs1 328 39 childhood childhood NN cord-309161-ceahghs1 328 40 experiences experience NNS cord-309161-ceahghs1 328 41 : : : cord-309161-ceahghs1 329 1 A a DT cord-309161-ceahghs1 329 2 scoping scoping NN cord-309161-ceahghs1 329 3 review review NN cord-309161-ceahghs1 329 4 INCREASED increase VBN cord-309161-ceahghs1 329 5 EXPRESSION expression NN cord-309161-ceahghs1 329 6 OF of IN cord-309161-ceahghs1 329 7 TELOMERE TELOMERE NNP cord-309161-ceahghs1 329 8 - - HYPH cord-309161-ceahghs1 329 9 REGULATING regulate VBG cord-309161-ceahghs1 329 10 GENES gene NNS cord-309161-ceahghs1 329 11 IN in IN cord-309161-ceahghs1 329 12 ENDURANCE endurance NN cord-309161-ceahghs1 329 13 ATHLETES athlete NNS cord-309161-ceahghs1 329 14 WITH with IN cord-309161-ceahghs1 329 15 LONG long JJ cord-309161-ceahghs1 329 16 LEUKOCYTE LEUKOCYTE NNP cord-309161-ceahghs1 329 17 TELOMERES TELOMERES NNP cord-309161-ceahghs1 329 18 Relationships Relationships NNPS cord-309161-ceahghs1 329 19 between between IN cord-309161-ceahghs1 329 20 positive positive JJ cord-309161-ceahghs1 329 21 psychological psychological JJ cord-309161-ceahghs1 329 22 constructs construct NNS cord-309161-ceahghs1 329 23 and and CC cord-309161-ceahghs1 329 24 health health NN cord-309161-ceahghs1 329 25 outcomes outcome NNS cord-309161-ceahghs1 329 26 in in IN cord-309161-ceahghs1 329 27 patients patient NNS cord-309161-ceahghs1 329 28 with with IN cord-309161-ceahghs1 329 29 cardiovascular cardiovascular JJ cord-309161-ceahghs1 329 30 disease disease NN cord-309161-ceahghs1 330 1 : : : cord-309161-ceahghs1 330 2 A a DT cord-309161-ceahghs1 330 3 systematic systematic JJ cord-309161-ceahghs1 330 4 review review NN cord-309161-ceahghs1 330 5 Embodied Embodied NNP cord-309161-ceahghs1 330 6 stress stress NN cord-309161-ceahghs1 330 7 : : : cord-309161-ceahghs1 330 8 The the DT cord-309161-ceahghs1 330 9 physiological physiological JJ cord-309161-ceahghs1 330 10 resonance resonance NN cord-309161-ceahghs1 330 11 of of IN cord-309161-ceahghs1 330 12 psychosocial psychosocial JJ cord-309161-ceahghs1 330 13 stress stress NN cord-309161-ceahghs1 331 1 The the DT cord-309161-ceahghs1 331 2 stress stress NN cord-309161-ceahghs1 331 3 field field NN cord-309161-ceahghs1 331 4 ages age NNS cord-309161-ceahghs1 331 5 : : : cord-309161-ceahghs1 331 6 A a DT cord-309161-ceahghs1 331 7 close close JJ cord-309161-ceahghs1 331 8 look look NN cord-309161-ceahghs1 331 9 into into IN cord-309161-ceahghs1 331 10 cellular cellular JJ cord-309161-ceahghs1 331 11 aging aging NN cord-309161-ceahghs1 331 12 processes process NNS cord-309161-ceahghs1 332 1 Psychological psychological JJ cord-309161-ceahghs1 332 2 and and CC cord-309161-ceahghs1 332 3 metabolic metabolic JJ cord-309161-ceahghs1 332 4 stress stress NN cord-309161-ceahghs1 332 5 : : : cord-309161-ceahghs1 333 1 A a DT cord-309161-ceahghs1 333 2 recipe recipe NN cord-309161-ceahghs1 333 3 for for IN cord-309161-ceahghs1 333 4 accelerated accelerate VBN cord-309161-ceahghs1 333 5 cellular cellular JJ cord-309161-ceahghs1 333 6 aging aging NN cord-309161-ceahghs1 333 7 ? ? . cord-309161-ceahghs1 334 1 Hormones hormone NNS cord-309161-ceahghs1 334 2 Can Can MD cord-309161-ceahghs1 334 3 Childhood childhood NN cord-309161-ceahghs1 334 4 Adversity adversity NN cord-309161-ceahghs1 334 5 Affect affect VBP cord-309161-ceahghs1 334 6 Telomeres telomere NNS cord-309161-ceahghs1 334 7 of of IN cord-309161-ceahghs1 334 8 the the DT cord-309161-ceahghs1 334 9 Next Next NNP cord-309161-ceahghs1 334 10 Generation Generation NNP cord-309161-ceahghs1 334 11 ? ? . cord-309161-ceahghs1 335 1 Possible possible JJ cord-309161-ceahghs1 335 2 Mechanisms Mechanisms NNPS cord-309161-ceahghs1 335 3 , , , cord-309161-ceahghs1 335 4 Implications implication NNS cord-309161-ceahghs1 335 5 , , , cord-309161-ceahghs1 335 6 and and CC cord-309161-ceahghs1 335 7 Next Next NNP cord-309161-ceahghs1 335 8 - - HYPH cord-309161-ceahghs1 335 9 Generation Generation NNP cord-309161-ceahghs1 335 10 Research Research NNP cord-309161-ceahghs1 335 11 Accelerated accelerate VBD cord-309161-ceahghs1 335 12 telomere telomere NN cord-309161-ceahghs1 335 13 shortening shorten VBG cord-309161-ceahghs1 335 14 in in IN cord-309161-ceahghs1 335 15 response response NN cord-309161-ceahghs1 335 16 to to IN cord-309161-ceahghs1 335 17 life life NN cord-309161-ceahghs1 335 18 stress stress NN cord-309161-ceahghs1 335 19 More More JJR cord-309161-ceahghs1 335 20 than than IN cord-309161-ceahghs1 335 21 a a DT cord-309161-ceahghs1 335 22 feeling feeling NN cord-309161-ceahghs1 335 23 : : : cord-309161-ceahghs1 336 1 A a DT cord-309161-ceahghs1 336 2 unified unified JJ cord-309161-ceahghs1 336 3 view view NN cord-309161-ceahghs1 336 4 of of IN cord-309161-ceahghs1 336 5 stress stress NN cord-309161-ceahghs1 336 6 measurement measurement NN cord-309161-ceahghs1 336 7 for for IN cord-309161-ceahghs1 336 8 population population NN cord-309161-ceahghs1 336 9 science science NN cord-309161-ceahghs1 336 10 Stress stress NN cord-309161-ceahghs1 336 11 biology biology NN cord-309161-ceahghs1 336 12 and and CC cord-309161-ceahghs1 336 13 aging aging NN cord-309161-ceahghs1 336 14 mechanisms mechanism NNS cord-309161-ceahghs1 336 15 : : : cord-309161-ceahghs1 337 1 Toward toward IN cord-309161-ceahghs1 337 2 understanding understand VBG cord-309161-ceahghs1 337 3 the the DT cord-309161-ceahghs1 337 4 deep deep JJ cord-309161-ceahghs1 337 5 connection connection NN cord-309161-ceahghs1 337 6 between between IN cord-309161-ceahghs1 337 7 adaptation adaptation NN cord-309161-ceahghs1 337 8 to to IN cord-309161-ceahghs1 337 9 stress stress NN cord-309161-ceahghs1 337 10 and and CC cord-309161-ceahghs1 337 11 longevity longevity NN cord-309161-ceahghs1 337 12 Embodying embody VBG cord-309161-ceahghs1 337 13 psychological psychological JJ cord-309161-ceahghs1 337 14 thriving thriving NN cord-309161-ceahghs1 337 15 : : : cord-309161-ceahghs1 337 16 Physical physical JJ cord-309161-ceahghs1 337 17 thriving thrive VBG cord-309161-ceahghs1 337 18 in in IN cord-309161-ceahghs1 337 19 response response NN cord-309161-ceahghs1 337 20 to to TO cord-309161-ceahghs1 337 21 stress stress VB cord-309161-ceahghs1 337 22 Stress stress NN cord-309161-ceahghs1 337 23 , , , cord-309161-ceahghs1 337 24 Telomeres telomere NNS cord-309161-ceahghs1 337 25 , , , cord-309161-ceahghs1 337 26 and and CC cord-309161-ceahghs1 337 27 Psychopathology psychopathology NN cord-309161-ceahghs1 337 28 : : : cord-309161-ceahghs1 337 29 Toward toward IN cord-309161-ceahghs1 337 30 a a DT cord-309161-ceahghs1 337 31 Deeper deep JJR cord-309161-ceahghs1 337 32 Understanding understanding NN cord-309161-ceahghs1 337 33 of of IN cord-309161-ceahghs1 337 34 a a DT cord-309161-ceahghs1 337 35 Triad Triad NNP cord-309161-ceahghs1 337 36 of of IN cord-309161-ceahghs1 337 37 Early Early NNP cord-309161-ceahghs1 337 38 Aging Aging NNP cord-309161-ceahghs1 337 39 Repeat Repeat NNP cord-309161-ceahghs1 337 40 remote remote JJ cord-309161-ceahghs1 337 41 ischaemic ischaemic JJ cord-309161-ceahghs1 337 42 pre pre NN cord-309161-ceahghs1 337 43 - - NN cord-309161-ceahghs1 337 44 conditioning conditioning NN cord-309161-ceahghs1 337 45 for for IN cord-309161-ceahghs1 337 46 improved improved JJ cord-309161-ceahghs1 337 47 cardiovascular cardiovascular JJ cord-309161-ceahghs1 337 48 function function NN cord-309161-ceahghs1 337 49 in in IN cord-309161-ceahghs1 337 50 humans human NNS cord-309161-ceahghs1 337 51 : : : cord-309161-ceahghs1 338 1 A a DT cord-309161-ceahghs1 338 2 systematic systematic JJ cord-309161-ceahghs1 338 3 review review NN cord-309161-ceahghs1 338 4 Appraisal appraisal NN cord-309161-ceahghs1 338 5 , , , cord-309161-ceahghs1 338 6 coping coping NN cord-309161-ceahghs1 338 7 , , , cord-309161-ceahghs1 338 8 health health NN cord-309161-ceahghs1 338 9 status status NN cord-309161-ceahghs1 338 10 , , , cord-309161-ceahghs1 338 11 and and CC cord-309161-ceahghs1 338 12 psychological psychological JJ cord-309161-ceahghs1 338 13 symptoms symptom NNS cord-309161-ceahghs1 339 1 The the DT cord-309161-ceahghs1 339 2 Continuum Continuum NNP cord-309161-ceahghs1 339 3 of of IN cord-309161-ceahghs1 339 4 Aging Aging NNP cord-309161-ceahghs1 339 5 and and CC cord-309161-ceahghs1 339 6 Age Age NNP cord-309161-ceahghs1 339 7 - - HYPH cord-309161-ceahghs1 339 8 Related relate VBN cord-309161-ceahghs1 339 9 Diseases disease NNS cord-309161-ceahghs1 339 10 : : : cord-309161-ceahghs1 339 11 Common common JJ cord-309161-ceahghs1 339 12 Mechanisms Mechanisms NNPS cord-309161-ceahghs1 339 13 but but CC cord-309161-ceahghs1 339 14 Different different JJ cord-309161-ceahghs1 339 15 Rates rate NNS cord-309161-ceahghs1 340 1 Ten ten CD cord-309161-ceahghs1 340 2 years year NNS cord-309161-ceahghs1 340 3 of of IN cord-309161-ceahghs1 340 4 life life NN cord-309161-ceahghs1 340 5 : : : cord-309161-ceahghs1 340 6 Is be VBZ cord-309161-ceahghs1 340 7 it -PRON- PRP cord-309161-ceahghs1 340 8 a a DT cord-309161-ceahghs1 340 9 matter matter NN cord-309161-ceahghs1 340 10 of of IN cord-309161-ceahghs1 340 11 choice choice NN cord-309161-ceahghs1 340 12 ? ? . cord-309161-ceahghs1 341 1 Trajectories trajectory NNS cord-309161-ceahghs1 341 2 of of IN cord-309161-ceahghs1 341 3 resilience resilience NN cord-309161-ceahghs1 341 4 and and CC cord-309161-ceahghs1 341 5 dysfunction dysfunction NN cord-309161-ceahghs1 341 6 following follow VBG cord-309161-ceahghs1 341 7 potential potential JJ cord-309161-ceahghs1 341 8 trauma trauma NN cord-309161-ceahghs1 341 9 : : : cord-309161-ceahghs1 342 1 A a DT cord-309161-ceahghs1 342 2 review review NN cord-309161-ceahghs1 342 3 and and CC cord-309161-ceahghs1 342 4 statistical statistical JJ cord-309161-ceahghs1 342 5 evaluation evaluation NN cord-309161-ceahghs1 342 6 Depression depression NN cord-309161-ceahghs1 342 7 increases increase VBZ cord-309161-ceahghs1 342 8 the the DT cord-309161-ceahghs1 342 9 risk risk NN cord-309161-ceahghs1 342 10 of of IN cord-309161-ceahghs1 342 11 mortality mortality NN cord-309161-ceahghs1 342 12 in in IN cord-309161-ceahghs1 342 13 patients patient NNS cord-309161-ceahghs1 342 14 with with IN cord-309161-ceahghs1 342 15 heart heart NN cord-309161-ceahghs1 342 16 failure failure NN cord-309161-ceahghs1 342 17 : : : cord-309161-ceahghs1 343 1 A a DT cord-309161-ceahghs1 343 2 meta meta JJ cord-309161-ceahghs1 343 3 - - HYPH cord-309161-ceahghs1 343 4 analysis analysis NN cord-309161-ceahghs1 343 5 Race race NN cord-309161-ceahghs1 343 6 - - HYPH cord-309161-ceahghs1 343 7 Ethnicity Ethnicity NNP cord-309161-ceahghs1 343 8 , , , cord-309161-ceahghs1 343 9 Poverty Poverty NNP cord-309161-ceahghs1 343 10 , , , cord-309161-ceahghs1 343 11 Urban Urban NNP cord-309161-ceahghs1 343 12 Stressors Stressors NNPS cord-309161-ceahghs1 343 13 , , , cord-309161-ceahghs1 343 14 and and CC cord-309161-ceahghs1 343 15 Telomere telomere NN cord-309161-ceahghs1 343 16 Length length NN cord-309161-ceahghs1 343 17 in in IN cord-309161-ceahghs1 343 18 a a DT cord-309161-ceahghs1 343 19 Detroit Detroit NNP cord-309161-ceahghs1 343 20 Community Community NNP cord-309161-ceahghs1 343 21 - - HYPH cord-309161-ceahghs1 343 22 based base VBN cord-309161-ceahghs1 343 23 Sample Sample NNP cord-309161-ceahghs1 343 24 Hospitalization Hospitalization NNP cord-309161-ceahghs1 343 25 , , , cord-309161-ceahghs1 343 26 restricted restricted JJ cord-309161-ceahghs1 343 27 activity activity NN cord-309161-ceahghs1 343 28 , , , cord-309161-ceahghs1 343 29 and and CC cord-309161-ceahghs1 343 30 the the DT cord-309161-ceahghs1 343 31 development development NN cord-309161-ceahghs1 343 32 of of IN cord-309161-ceahghs1 343 33 disability disability NN cord-309161-ceahghs1 343 34 among among IN cord-309161-ceahghs1 343 35 older old JJR cord-309161-ceahghs1 343 36 persons person NNS cord-309161-ceahghs1 343 37 Associations association NNS cord-309161-ceahghs1 343 38 between between IN cord-309161-ceahghs1 343 39 maternal maternal JJ cord-309161-ceahghs1 343 40 risk risk NN cord-309161-ceahghs1 343 41 factors factor NNS cord-309161-ceahghs1 343 42 of of IN cord-309161-ceahghs1 343 43 adverse adverse JJ cord-309161-ceahghs1 343 44 pregnancy pregnancy NN cord-309161-ceahghs1 343 45 and and CC cord-309161-ceahghs1 343 46 birth birth NN cord-309161-ceahghs1 343 47 outcomes outcome NNS cord-309161-ceahghs1 343 48 and and CC cord-309161-ceahghs1 343 49 the the DT cord-309161-ceahghs1 343 50 offspring offspring NN cord-309161-ceahghs1 343 51 epigenetic epigenetic JJ cord-309161-ceahghs1 343 52 clock clock NN cord-309161-ceahghs1 343 53 of of IN cord-309161-ceahghs1 343 54 gestational gestational JJ cord-309161-ceahghs1 343 55 age age NN cord-309161-ceahghs1 343 56 at at IN cord-309161-ceahghs1 343 57 birth birth NN cord-309161-ceahghs1 344 1 Substantial substantial JJ cord-309161-ceahghs1 344 2 health health NN cord-309161-ceahghs1 344 3 and and CC cord-309161-ceahghs1 344 4 economic economic JJ cord-309161-ceahghs1 344 5 returns return NNS cord-309161-ceahghs1 344 6 from from IN cord-309161-ceahghs1 344 7 delayed delay VBN cord-309161-ceahghs1 344 8 aging aging NN cord-309161-ceahghs1 344 9 may may MD cord-309161-ceahghs1 344 10 warrant warrant VB cord-309161-ceahghs1 344 11 a a DT cord-309161-ceahghs1 344 12 new new JJ cord-309161-ceahghs1 344 13 focus focus NN cord-309161-ceahghs1 344 14 for for IN cord-309161-ceahghs1 344 15 medical medical JJ cord-309161-ceahghs1 344 16 research research NN cord-309161-ceahghs1 345 1 The the DT cord-309161-ceahghs1 345 2 Baltimore Baltimore NNP cord-309161-ceahghs1 345 3 Experience Experience NNP cord-309161-ceahghs1 345 4 Corps Corps NNP cord-309161-ceahghs1 345 5 Trial Trial NNP cord-309161-ceahghs1 345 6 : : : cord-309161-ceahghs1 345 7 Enhancing enhance VBG cord-309161-ceahghs1 345 8 Generativity Generativity NNP cord-309161-ceahghs1 345 9 via via IN cord-309161-ceahghs1 345 10 Intergenerational Intergenerational NNP cord-309161-ceahghs1 345 11 Activity Activity NNP cord-309161-ceahghs1 345 12 Engagement Engagement NNP cord-309161-ceahghs1 345 13 in in IN cord-309161-ceahghs1 345 14 Later Later NNP cord-309161-ceahghs1 345 15 Life Life NNP cord-309161-ceahghs1 345 16 Burden Burden NNP cord-309161-ceahghs1 345 17 of of IN cord-309161-ceahghs1 345 18 Environmental Environmental NNP cord-309161-ceahghs1 345 19 Adversity Adversity NNP cord-309161-ceahghs1 346 1 Associated associate VBN cord-309161-ceahghs1 346 2 With with IN cord-309161-ceahghs1 346 3 Psychopathology Psychopathology NNP cord-309161-ceahghs1 346 4 , , , cord-309161-ceahghs1 346 5 Maturation Maturation NNP cord-309161-ceahghs1 346 6 , , , cord-309161-ceahghs1 346 7 and and CC cord-309161-ceahghs1 346 8 Brain Brain NNP cord-309161-ceahghs1 346 9 Behavior Behavior NNP cord-309161-ceahghs1 346 10 Parameters parameter NNS cord-309161-ceahghs1 346 11 in in IN cord-309161-ceahghs1 346 12 Youths Youths NNP cord-309161-ceahghs1 346 13 Mental mental JJ cord-309161-ceahghs1 346 14 distress distress NN cord-309161-ceahghs1 346 15 during during IN cord-309161-ceahghs1 346 16 the the DT cord-309161-ceahghs1 346 17 COVID-19 covid-19 JJ cord-309161-ceahghs1 346 18 pandemic pandemic NN cord-309161-ceahghs1 346 19 among among IN cord-309161-ceahghs1 346 20 US US NNP cord-309161-ceahghs1 346 21 adults adult NNS cord-309161-ceahghs1 346 22 without without IN cord-309161-ceahghs1 346 23 a a DT cord-309161-ceahghs1 346 24 pre pre JJ cord-309161-ceahghs1 346 25 - - JJ cord-309161-ceahghs1 346 26 existing existing JJ cord-309161-ceahghs1 346 27 mental mental JJ cord-309161-ceahghs1 346 28 health health NN cord-309161-ceahghs1 346 29 condition condition NN cord-309161-ceahghs1 346 30 : : : cord-309161-ceahghs1 346 31 Findings finding NNS cord-309161-ceahghs1 346 32 from from IN cord-309161-ceahghs1 346 33 American american JJ cord-309161-ceahghs1 346 34 trend trend NN cord-309161-ceahghs1 346 35 panel panel NN cord-309161-ceahghs1 346 36 survey survey NN cord-309161-ceahghs1 346 37 Frailty Frailty NNP cord-309161-ceahghs1 346 38 : : : cord-309161-ceahghs1 346 39 Implications implication NNS cord-309161-ceahghs1 346 40 for for IN cord-309161-ceahghs1 346 41 clinical clinical JJ cord-309161-ceahghs1 346 42 practice practice NN cord-309161-ceahghs1 346 43 and and CC cord-309161-ceahghs1 346 44 public public JJ cord-309161-ceahghs1 346 45 health health NN cord-309161-ceahghs1 347 1 The the DT cord-309161-ceahghs1 347 2 effect effect NN cord-309161-ceahghs1 347 3 of of IN cord-309161-ceahghs1 347 4 multiple multiple JJ cord-309161-ceahghs1 347 5 adverse adverse JJ cord-309161-ceahghs1 347 6 childhood childhood NN cord-309161-ceahghs1 347 7 experiences experience NNS cord-309161-ceahghs1 347 8 on on IN cord-309161-ceahghs1 347 9 health health NN cord-309161-ceahghs1 347 10 : : : cord-309161-ceahghs1 347 11 A a DT cord-309161-ceahghs1 347 12 systematic systematic JJ cord-309161-ceahghs1 347 13 review review NN cord-309161-ceahghs1 347 14 and and CC cord-309161-ceahghs1 347 15 meta meta NNP cord-309161-ceahghs1 347 16 - - HYPH cord-309161-ceahghs1 347 17 analysis analysis NN cord-309161-ceahghs1 347 18 . . . cord-309161-ceahghs1 348 1 The the DT cord-309161-ceahghs1 348 2 Lancet Lancet NNP cord-309161-ceahghs1 348 3 Frameworks Frameworks NNPS cord-309161-ceahghs1 348 4 for for IN cord-309161-ceahghs1 348 5 Proof Proof NNP cord-309161-ceahghs1 348 6 - - HYPH cord-309161-ceahghs1 348 7 of of IN cord-309161-ceahghs1 348 8 - - HYPH cord-309161-ceahghs1 348 9 Concept Concept NNP cord-309161-ceahghs1 348 10 Clinical Clinical NNP cord-309161-ceahghs1 348 11 Trials Trials NNPS cord-309161-ceahghs1 348 12 of of IN cord-309161-ceahghs1 348 13 Interventions Interventions NNPS cord-309161-ceahghs1 349 1 That that DT cord-309161-ceahghs1 349 2 Target target NN cord-309161-ceahghs1 350 1 Fundamental fundamental JJ cord-309161-ceahghs1 350 2 Aging age VBG cord-309161-ceahghs1 350 3 Processes Processes NNPS cord-309161-ceahghs1 350 4 A a DT cord-309161-ceahghs1 350 5 framework framework NN cord-309161-ceahghs1 350 6 for for IN cord-309161-ceahghs1 350 7 selection selection NN cord-309161-ceahghs1 350 8 of of IN cord-309161-ceahghs1 350 9 blood blood NN cord-309161-ceahghs1 350 10 - - HYPH cord-309161-ceahghs1 350 11 based base VBN cord-309161-ceahghs1 350 12 biomarkers biomarker NNS cord-309161-ceahghs1 350 13 for for IN cord-309161-ceahghs1 350 14 geroscience geroscience NN cord-309161-ceahghs1 350 15 - - HYPH cord-309161-ceahghs1 350 16 guided guide VBN cord-309161-ceahghs1 350 17 clinical clinical JJ cord-309161-ceahghs1 350 18 trials trial NNS cord-309161-ceahghs1 351 1 : : : cord-309161-ceahghs1 351 2 Report report VB cord-309161-ceahghs1 351 3 from from IN cord-309161-ceahghs1 351 4 the the DT cord-309161-ceahghs1 351 5 TAME TAME NNP cord-309161-ceahghs1 351 6 Geroscience Geroscience NNP cord-309161-ceahghs1 351 7 : : : cord-309161-ceahghs1 352 1 Linking link VBG cord-309161-ceahghs1 352 2 aging age VBG cord-309161-ceahghs1 352 3 to to IN cord-309161-ceahghs1 352 4 chronic chronic JJ cord-309161-ceahghs1 352 5 disease disease NN cord-309161-ceahghs1 352 6 Childhood Childhood NNP cord-309161-ceahghs1 352 7 adversity adversity NN cord-309161-ceahghs1 352 8 heightens heighten VBZ cord-309161-ceahghs1 352 9 the the DT cord-309161-ceahghs1 352 10 impact impact NN cord-309161-ceahghs1 352 11 of of IN cord-309161-ceahghs1 352 12 later later JJ cord-309161-ceahghs1 352 13 - - HYPH cord-309161-ceahghs1 352 14 life life NN cord-309161-ceahghs1 352 15 caregiving caregiving NN cord-309161-ceahghs1 352 16 stress stress NN cord-309161-ceahghs1 352 17 on on IN cord-309161-ceahghs1 352 18 telomere telomere JJ cord-309161-ceahghs1 352 19 length length NN cord-309161-ceahghs1 352 20 and and CC cord-309161-ceahghs1 352 21 inflammation inflammation NN cord-309161-ceahghs1 352 22 Social social JJ cord-309161-ceahghs1 352 23 network network NN cord-309161-ceahghs1 352 24 targeting target VBG cord-309161-ceahghs1 352 25 to to TO cord-309161-ceahghs1 352 26 maximise maximise VB cord-309161-ceahghs1 352 27 population population NN cord-309161-ceahghs1 352 28 behaviour behaviour NN cord-309161-ceahghs1 352 29 change change NN cord-309161-ceahghs1 352 30 : : : cord-309161-ceahghs1 352 31 A a DT cord-309161-ceahghs1 352 32 cluster cluster NN cord-309161-ceahghs1 352 33 randomised randomise VBN cord-309161-ceahghs1 352 34 controlled control VBN cord-309161-ceahghs1 352 35 trial trial NN cord-309161-ceahghs1 352 36 Voluntary voluntary JJ cord-309161-ceahghs1 352 37 activation activation NN cord-309161-ceahghs1 352 38 of of IN cord-309161-ceahghs1 352 39 the the DT cord-309161-ceahghs1 352 40 sympathetic sympathetic JJ cord-309161-ceahghs1 352 41 nervous nervous JJ cord-309161-ceahghs1 352 42 system system NN cord-309161-ceahghs1 352 43 and and CC cord-309161-ceahghs1 352 44 attenuation attenuation NN cord-309161-ceahghs1 352 45 of of IN cord-309161-ceahghs1 352 46 the the DT cord-309161-ceahghs1 352 47 innate innate JJ cord-309161-ceahghs1 352 48 immune immune JJ cord-309161-ceahghs1 352 49 response response NN cord-309161-ceahghs1 352 50 in in IN cord-309161-ceahghs1 352 51 humans human NNS cord-309161-ceahghs1 353 1 A a DT cord-309161-ceahghs1 353 2 randomized randomized JJ cord-309161-ceahghs1 353 3 control control NN cord-309161-ceahghs1 353 4 trial trial NN cord-309161-ceahghs1 353 5 to to TO cord-309161-ceahghs1 353 6 establish establish VB cord-309161-ceahghs1 353 7 the the DT cord-309161-ceahghs1 353 8 feasibility feasibility NN cord-309161-ceahghs1 353 9 and and CC cord-309161-ceahghs1 353 10 safety safety NN cord-309161-ceahghs1 353 11 of of IN cord-309161-ceahghs1 353 12 rapamycin rapamycin NN cord-309161-ceahghs1 353 13 treatment treatment NN cord-309161-ceahghs1 353 14 in in IN cord-309161-ceahghs1 353 15 an an DT cord-309161-ceahghs1 353 16 older old JJR cord-309161-ceahghs1 353 17 human human JJ cord-309161-ceahghs1 353 18 cohort cohort NN cord-309161-ceahghs1 353 19 : : : cord-309161-ceahghs1 353 20 Immunological immunological JJ cord-309161-ceahghs1 353 21 , , , cord-309161-ceahghs1 353 22 physical physical JJ cord-309161-ceahghs1 353 23 performance performance NN cord-309161-ceahghs1 353 24 , , , cord-309161-ceahghs1 353 25 and and CC cord-309161-ceahghs1 353 26 cognitive cognitive JJ cord-309161-ceahghs1 353 27 effects effect NNS cord-309161-ceahghs1 353 28 Life Life NNP cord-309161-ceahghs1 353 29 extension extension NN cord-309161-ceahghs1 353 30 after after IN cord-309161-ceahghs1 353 31 heat heat NN cord-309161-ceahghs1 353 32 shock shock NN cord-309161-ceahghs1 353 33 exposure exposure NN cord-309161-ceahghs1 353 34 : : : cord-309161-ceahghs1 354 1 Assessing assess VBG cord-309161-ceahghs1 354 2 meta meta JJ cord-309161-ceahghs1 354 3 - - HYPH cord-309161-ceahghs1 354 4 analytic analytic JJ cord-309161-ceahghs1 354 5 evidence evidence NN cord-309161-ceahghs1 354 6 for for IN cord-309161-ceahghs1 354 7 hormesis hormesis NN cord-309161-ceahghs1 354 8 Psychobiological Psychobiological NNP cord-309161-ceahghs1 354 9 factors factor NNS cord-309161-ceahghs1 354 10 of of IN cord-309161-ceahghs1 354 11 resilience resilience NN cord-309161-ceahghs1 354 12 and and CC cord-309161-ceahghs1 354 13 depression depression NN cord-309161-ceahghs1 354 14 in in IN cord-309161-ceahghs1 354 15 late late JJ cord-309161-ceahghs1 354 16 life life NN cord-309161-ceahghs1 355 1 The the DT cord-309161-ceahghs1 355 2 long long JJ cord-309161-ceahghs1 355 3 arm arm NN cord-309161-ceahghs1 355 4 of of IN cord-309161-ceahghs1 355 5 childhood childhood NN cord-309161-ceahghs1 355 6 experiences experience NNS cord-309161-ceahghs1 355 7 on on IN cord-309161-ceahghs1 355 8 longevity longevity NN cord-309161-ceahghs1 355 9 : : : cord-309161-ceahghs1 355 10 Testing test VBG cord-309161-ceahghs1 355 11 midlife midlife NN cord-309161-ceahghs1 355 12 vulnerability vulnerability NN cord-309161-ceahghs1 355 13 and and CC cord-309161-ceahghs1 355 14 resilience resilience NN cord-309161-ceahghs1 355 15 pathways pathway NNS cord-309161-ceahghs1 356 1 Understanding understand VBG cord-309161-ceahghs1 356 2 the the DT cord-309161-ceahghs1 356 3 Cumulative Cumulative NNP cord-309161-ceahghs1 356 4 Burden Burden NNP cord-309161-ceahghs1 356 5 of of IN cord-309161-ceahghs1 356 6 Basic basic JJ cord-309161-ceahghs1 356 7 Needs Needs NNPS cord-309161-ceahghs1 356 8 Insecurities insecurity NNS cord-309161-ceahghs1 357 1 : : : cord-309161-ceahghs1 357 2 Associations association NNS cord-309161-ceahghs1 357 3 With with IN cord-309161-ceahghs1 357 4 Health Health NNP cord-309161-ceahghs1 357 5 and and CC cord-309161-ceahghs1 357 6 Academic Academic NNP cord-309161-ceahghs1 357 7 Achievement Achievement NNP cord-309161-ceahghs1 357 8 Among among IN cord-309161-ceahghs1 357 9 College College NNP cord-309161-ceahghs1 357 10 Students student NNS cord-309161-ceahghs1 357 11 Preconditioning Preconditioning NNP cord-309161-ceahghs1 357 12 in in IN cord-309161-ceahghs1 357 13 neuroprotection neuroprotection NN cord-309161-ceahghs1 357 14 : : : cord-309161-ceahghs1 358 1 From from IN cord-309161-ceahghs1 358 2 hypoxia hypoxia NN cord-309161-ceahghs1 358 3 to to IN cord-309161-ceahghs1 358 4 ischemia ischemia NN cord-309161-ceahghs1 358 5 Acceptance acceptance NN cord-309161-ceahghs1 358 6 lowers lower VBZ cord-309161-ceahghs1 358 7 stress stress NN cord-309161-ceahghs1 358 8 reactivity reactivity NN cord-309161-ceahghs1 358 9 : : : cord-309161-ceahghs1 358 10 Dismantling dismantle VBG cord-309161-ceahghs1 358 11 mindfulness mindfulness NN cord-309161-ceahghs1 358 12 training training NN cord-309161-ceahghs1 358 13 in in IN cord-309161-ceahghs1 358 14 a a DT cord-309161-ceahghs1 358 15 randomized randomized JJ cord-309161-ceahghs1 358 16 controlled control VBN cord-309161-ceahghs1 358 17 trial trial NN cord-309161-ceahghs1 358 18 Peripheral peripheral JJ cord-309161-ceahghs1 358 19 blood blood NN cord-309161-ceahghs1 358 20 leukocyte leukocyte NN cord-309161-ceahghs1 358 21 telomere telomere NN cord-309161-ceahghs1 358 22 length length NN cord-309161-ceahghs1 358 23 is be VBZ cord-309161-ceahghs1 358 24 associated associate VBN cord-309161-ceahghs1 358 25 with with IN cord-309161-ceahghs1 358 26 J J NNP cord-309161-ceahghs1 358 27 o o NN cord-309161-ceahghs1 358 28 u u NN cord-309161-ceahghs1 358 29 r r NN cord-309161-ceahghs1 358 30 n n NN cord-309161-ceahghs1 358 31 a a DT cord-309161-ceahghs1 358 32 l l NN cord-309161-ceahghs1 358 33 P p NN cord-309161-ceahghs1 358 34 r r NN cord-309161-ceahghs1 358 35 e e NN cord-309161-ceahghs1 358 36 -p -p NN cord-309161-ceahghs1 359 1 r r NN cord-309161-ceahghs1 359 2 o o NN cord-309161-ceahghs1 359 3 o o NN cord-309161-ceahghs1 359 4 f f NN cord-309161-ceahghs1 359 5 survival survival NN cord-309161-ceahghs1 359 6 of of IN cord-309161-ceahghs1 359 7 sepsis sepsis NN cord-309161-ceahghs1 359 8 patients patient NNS cord-309161-ceahghs1 359 9 Programmed program VBD cord-309161-ceahghs1 359 10 longevity longevity NN cord-309161-ceahghs1 359 11 , , , cord-309161-ceahghs1 359 12 youthspan youthspan NNP cord-309161-ceahghs1 359 13 , , , cord-309161-ceahghs1 359 14 and and CC cord-309161-ceahghs1 359 15 juventology juventology NNP cord-309161-ceahghs1 360 1 The the DT cord-309161-ceahghs1 360 2 hallmarks hallmark NNS cord-309161-ceahghs1 360 3 of of IN cord-309161-ceahghs1 360 4 aging age VBG cord-309161-ceahghs1 360 5 Metformin Metformin NNP cord-309161-ceahghs1 360 6 Treatment Treatment NNP cord-309161-ceahghs1 360 7 Was be VBD cord-309161-ceahghs1 360 8 Associated associate VBN cord-309161-ceahghs1 360 9 with with IN cord-309161-ceahghs1 360 10 Decreased Decreased NNP cord-309161-ceahghs1 360 11 Mortality Mortality NNP cord-309161-ceahghs1 360 12 Patients patient NNS cord-309161-ceahghs1 360 13 with with IN cord-309161-ceahghs1 360 14 Diabetes diabete NNS cord-309161-ceahghs1 360 15 in in IN cord-309161-ceahghs1 360 16 a a DT cord-309161-ceahghs1 360 17 Retrospective Retrospective NNP cord-309161-ceahghs1 360 18 Analysis Analysis NNP cord-309161-ceahghs1 360 19 Association Association NNP cord-309161-ceahghs1 360 20 between between IN cord-309161-ceahghs1 360 21 socioeconomic socioeconomic JJ cord-309161-ceahghs1 360 22 status status NN cord-309161-ceahghs1 360 23 and and CC cord-309161-ceahghs1 360 24 metabolic metabolic JJ cord-309161-ceahghs1 360 25 syndrome syndrome NN cord-309161-ceahghs1 360 26 in in IN cord-309161-ceahghs1 360 27 women woman NNS cord-309161-ceahghs1 360 28 : : : cord-309161-ceahghs1 360 29 Testing test VBG cord-309161-ceahghs1 360 30 the the DT cord-309161-ceahghs1 360 31 reserve reserve NN cord-309161-ceahghs1 360 32 capacity capacity NN cord-309161-ceahghs1 360 33 model model NN cord-309161-ceahghs1 360 34 . . . cord-309161-ceahghs1 361 1 Health health NN cord-309161-ceahghs1 361 2 Psychology psychology NN cord-309161-ceahghs1 361 3 : : : cord-309161-ceahghs1 362 1 Official Official NNP cord-309161-ceahghs1 362 2 Journal Journal NNP cord-309161-ceahghs1 362 3 of of IN cord-309161-ceahghs1 362 4 the the DT cord-309161-ceahghs1 362 5 Division Division NNP cord-309161-ceahghs1 362 6 of of IN cord-309161-ceahghs1 362 7 Health Health NNP cord-309161-ceahghs1 362 8 Psychology Psychology NNP cord-309161-ceahghs1 362 9 Hormesis Hormesis NNP cord-309161-ceahghs1 362 10 defined define VBD cord-309161-ceahghs1 362 11 Hormesis Hormesis NNP cord-309161-ceahghs1 362 12 and and CC cord-309161-ceahghs1 362 13 disease disease NN cord-309161-ceahghs1 362 14 resistance resistance NN cord-309161-ceahghs1 362 15 : : : cord-309161-ceahghs1 363 1 Activation activation NN cord-309161-ceahghs1 363 2 of of IN cord-309161-ceahghs1 363 3 cellular cellular JJ cord-309161-ceahghs1 363 4 stress stress NN cord-309161-ceahghs1 363 5 response response NN cord-309161-ceahghs1 363 6 pathways pathway NNS cord-309161-ceahghs1 363 7 Hallmarks Hallmarks NNPS cord-309161-ceahghs1 363 8 of of IN cord-309161-ceahghs1 363 9 Brain Brain NNP cord-309161-ceahghs1 363 10 Aging aging NN cord-309161-ceahghs1 363 11 : : : cord-309161-ceahghs1 364 1 Adaptive adaptive JJ cord-309161-ceahghs1 364 2 and and CC cord-309161-ceahghs1 364 3 Pathological pathological JJ cord-309161-ceahghs1 364 4 Modification Modification NNP cord-309161-ceahghs1 364 5 by by IN cord-309161-ceahghs1 364 6 Metabolic Metabolic NNP cord-309161-ceahghs1 364 7 States States NNPS cord-309161-ceahghs1 364 8 Protection Protection NNP cord-309161-ceahghs1 364 9 and and CC cord-309161-ceahghs1 364 10 damage damage NN cord-309161-ceahghs1 364 11 from from IN cord-309161-ceahghs1 364 12 acute acute JJ cord-309161-ceahghs1 364 13 and and CC cord-309161-ceahghs1 364 14 chronic chronic JJ cord-309161-ceahghs1 364 15 stress stress NN cord-309161-ceahghs1 364 16 : : : cord-309161-ceahghs1 365 1 Allostasis Allostasis NNP cord-309161-ceahghs1 365 2 and and CC cord-309161-ceahghs1 365 3 allostatic allostatic JJ cord-309161-ceahghs1 365 4 overload overload NN cord-309161-ceahghs1 365 5 and and CC cord-309161-ceahghs1 365 6 relevance relevance NN cord-309161-ceahghs1 365 7 to to IN cord-309161-ceahghs1 365 8 the the DT cord-309161-ceahghs1 365 9 pathophysiology pathophysiology NN cord-309161-ceahghs1 365 10 of of IN cord-309161-ceahghs1 365 11 psychiatric psychiatric JJ cord-309161-ceahghs1 365 12 disorders disorder NNS cord-309161-ceahghs1 366 1 The the DT cord-309161-ceahghs1 366 2 brain brain NN cord-309161-ceahghs1 366 3 on on IN cord-309161-ceahghs1 366 4 stress stress NN cord-309161-ceahghs1 366 5 : : : cord-309161-ceahghs1 367 1 Vulnerability vulnerability NN cord-309161-ceahghs1 367 2 and and CC cord-309161-ceahghs1 367 3 plasticity plasticity NN cord-309161-ceahghs1 367 4 of of IN cord-309161-ceahghs1 367 5 the the DT cord-309161-ceahghs1 367 6 prefrontal prefrontal JJ cord-309161-ceahghs1 367 7 cortex cortex NNP cord-309161-ceahghs1 367 8 over over IN cord-309161-ceahghs1 367 9 the the DT cord-309161-ceahghs1 367 10 life life NN cord-309161-ceahghs1 367 11 course course NN cord-309161-ceahghs1 367 12 Remote Remote NNP cord-309161-ceahghs1 367 13 Ischemic Ischemic NNP cord-309161-ceahghs1 367 14 Perconditioning Perconditioning NNP cord-309161-ceahghs1 367 15 to to TO cord-309161-ceahghs1 367 16 Reduce reduce VB cord-309161-ceahghs1 367 17 Reperfusion reperfusion NN cord-309161-ceahghs1 367 18 Injury injury NN cord-309161-ceahghs1 367 19 During during IN cord-309161-ceahghs1 367 20 Acute acute JJ cord-309161-ceahghs1 367 21 ST ST NNP cord-309161-ceahghs1 367 22 - - HYPH cord-309161-ceahghs1 367 23 Segment Segment NNP cord-309161-ceahghs1 367 24 - - HYPH cord-309161-ceahghs1 367 25 Elevation Elevation NNP cord-309161-ceahghs1 367 26 Myocardial Myocardial NNP cord-309161-ceahghs1 367 27 Infarction Infarction NNP cord-309161-ceahghs1 367 28 : : : cord-309161-ceahghs1 367 29 A a DT cord-309161-ceahghs1 367 30 Systematic Systematic NNP cord-309161-ceahghs1 367 31 Review Review NNP cord-309161-ceahghs1 367 32 and and CC cord-309161-ceahghs1 367 33 Meta Meta NNP cord-309161-ceahghs1 367 34 - - HYPH cord-309161-ceahghs1 367 35 Analysis Analysis NNP cord-309161-ceahghs1 368 1 A a DT cord-309161-ceahghs1 368 2 functional functional JJ cord-309161-ceahghs1 368 3 genomic genomic JJ cord-309161-ceahghs1 368 4 fingerprint fingerprint NN cord-309161-ceahghs1 368 5 of of IN cord-309161-ceahghs1 368 6 chronic chronic JJ cord-309161-ceahghs1 368 7 stress stress NN cord-309161-ceahghs1 368 8 in in IN cord-309161-ceahghs1 368 9 humans human NNS cord-309161-ceahghs1 368 10 : : : cord-309161-ceahghs1 368 11 Blunted blunt VBN cord-309161-ceahghs1 368 12 glucocorticoid glucocorticoid JJ cord-309161-ceahghs1 368 13 and and CC cord-309161-ceahghs1 368 14 increased increase VBN cord-309161-ceahghs1 368 15 NF NF NNP cord-309161-ceahghs1 368 16 - - HYPH cord-309161-ceahghs1 368 17 kappaB kappaB NNP cord-309161-ceahghs1 368 18 signaling signal VBG cord-309161-ceahghs1 368 19 Exercise exercise NN cord-309161-ceahghs1 368 20 , , , cord-309161-ceahghs1 368 21 Autophagy Autophagy NNP cord-309161-ceahghs1 368 22 , , , cord-309161-ceahghs1 368 23 and and CC cord-309161-ceahghs1 368 24 Apoptosis Apoptosis NNP cord-309161-ceahghs1 368 25 Emotional Emotional NNP cord-309161-ceahghs1 368 26 Reactivity Reactivity NNP cord-309161-ceahghs1 368 27 and and CC cord-309161-ceahghs1 368 28 Mortality mortality NN cord-309161-ceahghs1 368 29 : : : cord-309161-ceahghs1 368 30 Longitudinal Longitudinal NNP cord-309161-ceahghs1 368 31 Findings finding NNS cord-309161-ceahghs1 368 32 From from IN cord-309161-ceahghs1 368 33 the the DT cord-309161-ceahghs1 368 34 VA VA NNP cord-309161-ceahghs1 368 35 Normative Normative NNP cord-309161-ceahghs1 368 36 Aging Aging NNP cord-309161-ceahghs1 368 37 Study Study NNP cord-309161-ceahghs1 368 38 Multiplex Multiplex NNP cord-309161-ceahghs1 368 39 stress stress NN cord-309161-ceahghs1 368 40 resistance resistance NN cord-309161-ceahghs1 368 41 in in IN cord-309161-ceahghs1 368 42 cells cell NNS cord-309161-ceahghs1 368 43 from from IN cord-309161-ceahghs1 368 44 longlived longlived JJ cord-309161-ceahghs1 368 45 dwarf dwarf NN cord-309161-ceahghs1 368 46 mice mouse NNS cord-309161-ceahghs1 368 47 Exercise exercise NN cord-309161-ceahghs1 368 48 - - HYPH cord-309161-ceahghs1 368 49 Induced Induced NNP cord-309161-ceahghs1 368 50 Mitohormesis Mitohormesis NNP cord-309161-ceahghs1 368 51 for for IN cord-309161-ceahghs1 368 52 the the DT cord-309161-ceahghs1 368 53 Maintenance Maintenance NNP cord-309161-ceahghs1 368 54 of of IN cord-309161-ceahghs1 368 55 Skeletal skeletal JJ cord-309161-ceahghs1 368 56 Muscle Muscle NNP cord-309161-ceahghs1 368 57 and and CC cord-309161-ceahghs1 368 58 Healthspan Healthspan NNP cord-309161-ceahghs1 368 59 Extension Extension NNP cord-309161-ceahghs1 368 60 Creating create VBG cord-309161-ceahghs1 368 61 the the DT cord-309161-ceahghs1 368 62 Next next JJ cord-309161-ceahghs1 368 63 Generation Generation NNP cord-309161-ceahghs1 368 64 of of IN cord-309161-ceahghs1 368 65 Translational Translational NNP cord-309161-ceahghs1 368 66 Geroscientists Geroscientists NNPS cord-309161-ceahghs1 369 1 The the DT cord-309161-ceahghs1 369 2 NIH NIH NNP cord-309161-ceahghs1 369 3 Science Science NNP cord-309161-ceahghs1 369 4 of of IN cord-309161-ceahghs1 369 5 Behavior Behavior NNP cord-309161-ceahghs1 369 6 Change Change NNP cord-309161-ceahghs1 369 7 Program Program NNP cord-309161-ceahghs1 369 8 : : : cord-309161-ceahghs1 369 9 Transforming transform VBG cord-309161-ceahghs1 369 10 the the DT cord-309161-ceahghs1 369 11 science science NN cord-309161-ceahghs1 369 12 through through IN cord-309161-ceahghs1 369 13 a a DT cord-309161-ceahghs1 369 14 focus focus NN cord-309161-ceahghs1 369 15 on on IN cord-309161-ceahghs1 369 16 mechanisms mechanism NNS cord-309161-ceahghs1 369 17 of of IN cord-309161-ceahghs1 369 18 change change NN cord-309161-ceahghs1 369 19 Exaggerated exaggerated JJ cord-309161-ceahghs1 369 20 neurobiological neurobiological JJ cord-309161-ceahghs1 369 21 sensitivity sensitivity NN cord-309161-ceahghs1 369 22 to to IN cord-309161-ceahghs1 369 23 threat threat NN cord-309161-ceahghs1 369 24 as as IN cord-309161-ceahghs1 369 25 a a DT cord-309161-ceahghs1 369 26 mechanism mechanism NN cord-309161-ceahghs1 369 27 linking link VBG cord-309161-ceahghs1 369 28 anxiety anxiety NN cord-309161-ceahghs1 369 29 with with IN cord-309161-ceahghs1 369 30 increased increase VBN cord-309161-ceahghs1 369 31 risk risk NN cord-309161-ceahghs1 369 32 for for IN cord-309161-ceahghs1 369 33 diseases disease NNS cord-309161-ceahghs1 369 34 of of IN cord-309161-ceahghs1 369 35 aging age VBG cord-309161-ceahghs1 369 36 Influence influence NN cord-309161-ceahghs1 369 37 of of IN cord-309161-ceahghs1 369 38 NAD+ NAD+ NNP cord-309161-ceahghs1 369 39 as as IN cord-309161-ceahghs1 369 40 an an DT cord-309161-ceahghs1 369 41 ageing age VBG cord-309161-ceahghs1 369 42 - - HYPH cord-309161-ceahghs1 369 43 related relate VBN cord-309161-ceahghs1 369 44 immunomodulator immunomodulator NN cord-309161-ceahghs1 369 45 on on IN cord-309161-ceahghs1 369 46 COVID COVID NNP cord-309161-ceahghs1 369 47 19 19 CD cord-309161-ceahghs1 369 48 infection infection NN cord-309161-ceahghs1 369 49 : : : cord-309161-ceahghs1 370 1 A a DT cord-309161-ceahghs1 370 2 hypothesis hypothesis NN cord-309161-ceahghs1 371 1 The the DT cord-309161-ceahghs1 371 2 loneliness loneliness NN cord-309161-ceahghs1 371 3 pandemic pandemic NN cord-309161-ceahghs1 371 4 : : : cord-309161-ceahghs1 371 5 Loneliness loneliness NN cord-309161-ceahghs1 371 6 and and CC cord-309161-ceahghs1 371 7 other other JJ cord-309161-ceahghs1 371 8 concomitants concomitant NNS cord-309161-ceahghs1 371 9 of of IN cord-309161-ceahghs1 371 10 depression depression NN cord-309161-ceahghs1 371 11 , , , cord-309161-ceahghs1 371 12 anxiety anxiety NN cord-309161-ceahghs1 371 13 and and CC cord-309161-ceahghs1 371 14 their -PRON- PRP$ cord-309161-ceahghs1 371 15 comorbidity comorbidity NN cord-309161-ceahghs1 371 16 during during IN cord-309161-ceahghs1 372 1 the the DT cord-309161-ceahghs1 372 2 COVID-19 COVID-19 NNP cord-309161-ceahghs1 372 3 outbreak outbreak NN cord-309161-ceahghs1 372 4 Stress Stress NNP cord-309161-ceahghs1 372 5 , , , cord-309161-ceahghs1 372 6 epigenetics epigenetics NN cord-309161-ceahghs1 372 7 and and CC cord-309161-ceahghs1 372 8 depression depression NN cord-309161-ceahghs1 372 9 : : : cord-309161-ceahghs1 372 10 A a DT cord-309161-ceahghs1 372 11 systematic systematic JJ cord-309161-ceahghs1 372 12 review review NN cord-309161-ceahghs1 372 13 Where where WRB cord-309161-ceahghs1 372 14 You -PRON- PRP cord-309161-ceahghs1 372 15 Live live VBP cord-309161-ceahghs1 373 1 May May MD cord-309161-ceahghs1 373 2 Make make VB cord-309161-ceahghs1 373 3 You -PRON- PRP cord-309161-ceahghs1 373 4 Old old JJ cord-309161-ceahghs1 373 5 : : : cord-309161-ceahghs1 374 1 The the DT cord-309161-ceahghs1 374 2 Association Association NNP cord-309161-ceahghs1 374 3 between between IN cord-309161-ceahghs1 374 4 Perceived Perceived NNP cord-309161-ceahghs1 374 5 Poor Poor NNP cord-309161-ceahghs1 374 6 Neighborhood Neighborhood NNP cord-309161-ceahghs1 374 7 Quality Quality NNP cord-309161-ceahghs1 374 8 and and CC cord-309161-ceahghs1 374 9 Leukocyte Leukocyte NNP cord-309161-ceahghs1 374 10 Telomere Telomere NNP cord-309161-ceahghs1 374 11 Length Length NNP cord-309161-ceahghs1 374 12 Affective Affective NNP cord-309161-ceahghs1 374 13 reactivity reactivity NN cord-309161-ceahghs1 374 14 to to IN cord-309161-ceahghs1 374 15 daily daily JJ cord-309161-ceahghs1 374 16 stressors stressor NNS cord-309161-ceahghs1 374 17 and and CC cord-309161-ceahghs1 374 18 long long JJ cord-309161-ceahghs1 374 19 - - HYPH cord-309161-ceahghs1 374 20 term term NN cord-309161-ceahghs1 374 21 risk risk NN cord-309161-ceahghs1 374 22 of of IN cord-309161-ceahghs1 374 23 reporting report VBG cord-309161-ceahghs1 374 24 a a DT cord-309161-ceahghs1 374 25 chronic chronic JJ cord-309161-ceahghs1 374 26 physical physical JJ cord-309161-ceahghs1 374 27 health health NN cord-309161-ceahghs1 374 28 condition condition NN cord-309161-ceahghs1 374 29 A A NNP cord-309161-ceahghs1 374 30 Mitochondrial Mitochondrial NNP cord-309161-ceahghs1 374 31 Health Health NNP cord-309161-ceahghs1 374 32 Index Index NNP cord-309161-ceahghs1 374 33 Sensitive sensitive JJ cord-309161-ceahghs1 374 34 to to IN cord-309161-ceahghs1 374 35 Mood Mood NNP cord-309161-ceahghs1 374 36 and and CC cord-309161-ceahghs1 374 37 Caregiving Caregiving NNP cord-309161-ceahghs1 374 38 Stress Stress NNP cord-309161-ceahghs1 374 39 Influence Influence NNP cord-309161-ceahghs1 374 40 of of IN cord-309161-ceahghs1 374 41 a a DT cord-309161-ceahghs1 374 42 10-Day 10-day JJ cord-309161-ceahghs1 374 43 Mimic mimic NN cord-309161-ceahghs1 374 44 of of IN cord-309161-ceahghs1 374 45 Our -PRON- PRP$ cord-309161-ceahghs1 374 46 Ancient Ancient NNP cord-309161-ceahghs1 374 47 Lifestyle Lifestyle NNP cord-309161-ceahghs1 374 48 on on IN cord-309161-ceahghs1 374 49 Anthropometrics Anthropometrics NNPS cord-309161-ceahghs1 374 50 and and CC cord-309161-ceahghs1 374 51 Parameters parameter NNS cord-309161-ceahghs1 374 52 of of IN cord-309161-ceahghs1 374 53 Metabolism metabolism NN cord-309161-ceahghs1 374 54 and and CC cord-309161-ceahghs1 374 55 Inflammation inflammation NN cord-309161-ceahghs1 374 56 : : : cord-309161-ceahghs1 374 57 The the DT cord-309161-ceahghs1 374 58 " " `` cord-309161-ceahghs1 374 59 Study Study NNP cord-309161-ceahghs1 374 60 of of IN cord-309161-ceahghs1 374 61 Origin Origin NNP cord-309161-ceahghs1 374 62 Aerobic aerobic JJ cord-309161-ceahghs1 374 63 exercise exercise NN cord-309161-ceahghs1 374 64 lengthens lengthen VBZ cord-309161-ceahghs1 374 65 telomeres telomere NNS cord-309161-ceahghs1 374 66 and and CC cord-309161-ceahghs1 374 67 reduces reduce VBZ cord-309161-ceahghs1 374 68 stress stress NN cord-309161-ceahghs1 374 69 in in IN cord-309161-ceahghs1 374 70 family family NN cord-309161-ceahghs1 374 71 caregivers caregiver NNS cord-309161-ceahghs1 374 72 : : : cord-309161-ceahghs1 375 1 A a DT cord-309161-ceahghs1 375 2 randomized randomized JJ cord-309161-ceahghs1 375 3 controlled control VBN cord-309161-ceahghs1 375 4 trial trial NN cord-309161-ceahghs1 375 5 -Curt -Curt NNP cord-309161-ceahghs1 375 6 Richter Richter NNP cord-309161-ceahghs1 375 7 Award Award NNP cord-309161-ceahghs1 375 8 Exercise Exercise NNP cord-309161-ceahghs1 375 9 , , , cord-309161-ceahghs1 375 10 oxidants oxidant NNS cord-309161-ceahghs1 375 11 , , , cord-309161-ceahghs1 375 12 and and CC cord-309161-ceahghs1 375 13 antioxidants antioxidant NNS cord-309161-ceahghs1 375 14 change change VBP cord-309161-ceahghs1 375 15 the the DT cord-309161-ceahghs1 375 16 shape shape NN cord-309161-ceahghs1 375 17 of of IN cord-309161-ceahghs1 375 18 the the DT cord-309161-ceahghs1 375 19 bell bell NN cord-309161-ceahghs1 375 20 - - HYPH cord-309161-ceahghs1 375 21 shaped shape VBN cord-309161-ceahghs1 375 22 hormesis hormesis NN cord-309161-ceahghs1 375 23 curve curve NN cord-309161-ceahghs1 376 1 A a DT cord-309161-ceahghs1 376 2 Systematic Systematic NNP cord-309161-ceahghs1 376 3 Review Review NNP cord-309161-ceahghs1 376 4 and and CC cord-309161-ceahghs1 376 5 Meta Meta NNP cord-309161-ceahghs1 376 6 - - HYPH cord-309161-ceahghs1 376 7 Analysis Analysis NNP cord-309161-ceahghs1 376 8 of of IN cord-309161-ceahghs1 376 9 the the DT cord-309161-ceahghs1 376 10 Impact Impact NNP cord-309161-ceahghs1 376 11 of of IN cord-309161-ceahghs1 376 12 Mindfulness Mindfulness NNP cord-309161-ceahghs1 376 13 Based Based NNP cord-309161-ceahghs1 376 14 Interventions Interventions NNPS cord-309161-ceahghs1 376 15 on on IN cord-309161-ceahghs1 376 16 Heart heart NN cord-309161-ceahghs1 376 17 Rate rate NN cord-309161-ceahghs1 376 18 Variability variability NN cord-309161-ceahghs1 376 19 and and CC cord-309161-ceahghs1 376 20 Inflammatory Inflammatory NNP cord-309161-ceahghs1 376 21 Markers Markers NNPS cord-309161-ceahghs1 376 22 Clarifying clarify VBG cord-309161-ceahghs1 376 23 the the DT cord-309161-ceahghs1 376 24 Roles Roles NNPS cord-309161-ceahghs1 376 25 of of IN cord-309161-ceahghs1 376 26 Homeostasis Homeostasis NNP cord-309161-ceahghs1 376 27 and and CC cord-309161-ceahghs1 376 28 Allostasis Allostasis NNP cord-309161-ceahghs1 376 29 in in IN cord-309161-ceahghs1 376 30 Physiological physiological JJ cord-309161-ceahghs1 376 31 Regulation regulation NN cord-309161-ceahghs1 377 1 Fasting fast VBG cord-309161-ceahghs1 377 2 - - HYPH cord-309161-ceahghs1 377 3 Mimicking mimic VBG cord-309161-ceahghs1 377 4 Diet diet NN cord-309161-ceahghs1 377 5 Modulates modulate VBZ cord-309161-ceahghs1 377 6 Microbiota Microbiota NNP cord-309161-ceahghs1 377 7 and and CC cord-309161-ceahghs1 377 8 Promotes promote VBZ cord-309161-ceahghs1 377 9 Intestinal intestinal JJ cord-309161-ceahghs1 377 10 Regeneration regeneration NN cord-309161-ceahghs1 377 11 to to TO cord-309161-ceahghs1 377 12 Reduce reduce VB cord-309161-ceahghs1 377 13 Inflammatory inflammatory JJ cord-309161-ceahghs1 377 14 Bowel bowel NN cord-309161-ceahghs1 377 15 Disease Disease NNP cord-309161-ceahghs1 377 16 Pathology Pathology NNP cord-309161-ceahghs1 377 17 Hormesis Hormesis NNP cord-309161-ceahghs1 377 18 in in IN cord-309161-ceahghs1 377 19 aging age VBG cord-309161-ceahghs1 377 20 Relationship relationship NN cord-309161-ceahghs1 377 21 closeness closeness NN cord-309161-ceahghs1 377 22 buffers buffer VBZ cord-309161-ceahghs1 377 23 the the DT cord-309161-ceahghs1 377 24 effects effect NNS cord-309161-ceahghs1 377 25 of of IN cord-309161-ceahghs1 377 26 perceived perceive VBN cord-309161-ceahghs1 377 27 stress stress NN cord-309161-ceahghs1 377 28 on on IN cord-309161-ceahghs1 377 29 transcriptomic transcriptomic JJ cord-309161-ceahghs1 377 30 indicators indicator NNS cord-309161-ceahghs1 377 31 of of IN cord-309161-ceahghs1 377 32 cellular cellular JJ cord-309161-ceahghs1 377 33 stress stress NN cord-309161-ceahghs1 377 34 and and CC cord-309161-ceahghs1 377 35 biological biological JJ cord-309161-ceahghs1 377 36 aging age VBG cord-309161-ceahghs1 377 37 marker marker NN cord-309161-ceahghs1 377 38 p16INK4a p16INK4a NNP cord-309161-ceahghs1 377 39 Epigenetic epigenetic JJ cord-309161-ceahghs1 377 40 age age NN cord-309161-ceahghs1 377 41 and and CC cord-309161-ceahghs1 377 42 pregnancy pregnancy NN cord-309161-ceahghs1 377 43 outcomes outcome NNS cord-309161-ceahghs1 377 44 : : : cord-309161-ceahghs1 377 45 GrimAge GrimAge NNP cord-309161-ceahghs1 377 46 acceleration acceleration NN cord-309161-ceahghs1 377 47 is be VBZ cord-309161-ceahghs1 377 48 associated associate VBN cord-309161-ceahghs1 377 49 with with IN cord-309161-ceahghs1 377 50 shorter short JJR cord-309161-ceahghs1 377 51 gestational gestational JJ cord-309161-ceahghs1 377 52 length length NN cord-309161-ceahghs1 377 53 and and CC cord-309161-ceahghs1 377 54 lower low JJR cord-309161-ceahghs1 377 55 birthweight birthweight JJ cord-309161-ceahghs1 377 56 Association Association NNP cord-309161-ceahghs1 377 57 of of IN cord-309161-ceahghs1 377 58 Optimism Optimism NNP cord-309161-ceahghs1 377 59 With with IN cord-309161-ceahghs1 377 60 Cardiovascular cardiovascular JJ cord-309161-ceahghs1 377 61 Events event NNS cord-309161-ceahghs1 377 62 and and CC cord-309161-ceahghs1 377 63 All all DT cord-309161-ceahghs1 377 64 - - HYPH cord-309161-ceahghs1 377 65 Cause cause NN cord-309161-ceahghs1 377 66 Mortality mortality NN cord-309161-ceahghs1 377 67 : : : cord-309161-ceahghs1 378 1 A a DT cord-309161-ceahghs1 378 2 Systematic Systematic NNP cord-309161-ceahghs1 378 3 Review Review NNP cord-309161-ceahghs1 378 4 and and CC cord-309161-ceahghs1 378 5 Metaanalysis Metaanalysis NNP cord-309161-ceahghs1 378 6 COVID-19 COVID-19 NNP cord-309161-ceahghs1 378 7 and and CC cord-309161-ceahghs1 378 8 Crosstalk crosstalk NN cord-309161-ceahghs1 378 9 With with IN cord-309161-ceahghs1 378 10 the the DT cord-309161-ceahghs1 378 11 Hallmarks Hallmarks NNP cord-309161-ceahghs1 378 12 of of IN cord-309161-ceahghs1 378 13 Aging age VBG cord-309161-ceahghs1 378 14 The the DT cord-309161-ceahghs1 378 15 genetics genetic NNS cord-309161-ceahghs1 378 16 of of IN cord-309161-ceahghs1 378 17 human human JJ cord-309161-ceahghs1 378 18 personality personality NN cord-309161-ceahghs1 378 19 COVID-19 COVID-19 NNP cord-309161-ceahghs1 378 20 and and CC cord-309161-ceahghs1 378 21 chronological chronological JJ cord-309161-ceahghs1 378 22 aging aging NN cord-309161-ceahghs1 378 23 : : : cord-309161-ceahghs1 378 24 Senolytics senolytic NNS cord-309161-ceahghs1 378 25 and and CC cord-309161-ceahghs1 378 26 other other JJ cord-309161-ceahghs1 378 27 anti anti JJ cord-309161-ceahghs1 378 28 - - JJ cord-309161-ceahghs1 378 29 aging aging JJ cord-309161-ceahghs1 378 30 drugs drug NNS cord-309161-ceahghs1 378 31 for for IN cord-309161-ceahghs1 378 32 the the DT cord-309161-ceahghs1 378 33 treatment treatment NN cord-309161-ceahghs1 378 34 or or CC cord-309161-ceahghs1 378 35 prevention prevention NN cord-309161-ceahghs1 378 36 of of IN cord-309161-ceahghs1 378 37 corona corona NNP cord-309161-ceahghs1 378 38 virus virus NN cord-309161-ceahghs1 378 39 infection infection NN cord-309161-ceahghs1 378 40 Allostasis Allostasis NNP cord-309161-ceahghs1 378 41 : : : cord-309161-ceahghs1 378 42 A a DT cord-309161-ceahghs1 378 43 Brain Brain NNP cord-309161-ceahghs1 378 44 - - HYPH cord-309161-ceahghs1 378 45 Centered center VBN cord-309161-ceahghs1 378 46 , , , cord-309161-ceahghs1 378 47 Predictive Predictive NNP cord-309161-ceahghs1 378 48 Mode Mode NNP cord-309161-ceahghs1 378 49 of of IN cord-309161-ceahghs1 378 50 Physiological physiological JJ cord-309161-ceahghs1 378 51 Regulation Regulation NNP cord-309161-ceahghs1 378 52 Translational Translational NNP cord-309161-ceahghs1 378 53 geroscience geroscience NN cord-309161-ceahghs1 378 54 : : : cord-309161-ceahghs1 379 1 Emphasizing emphasize VBG cord-309161-ceahghs1 379 2 function function NN cord-309161-ceahghs1 379 3 to to TO cord-309161-ceahghs1 379 4 achieve achieve VB cord-309161-ceahghs1 379 5 optimal optimal JJ cord-309161-ceahghs1 379 6 longevity longevity NN cord-309161-ceahghs1 379 7 Allostatic Allostatic NNP cord-309161-ceahghs1 379 8 load load NN cord-309161-ceahghs1 379 9 as as IN cord-309161-ceahghs1 379 10 a a DT cord-309161-ceahghs1 379 11 marker marker NN cord-309161-ceahghs1 379 12 of of IN cord-309161-ceahghs1 379 13 cumulative cumulative JJ cord-309161-ceahghs1 379 14 biological biological JJ cord-309161-ceahghs1 379 15 risk risk NN cord-309161-ceahghs1 379 16 : : : cord-309161-ceahghs1 379 17 MacArthur MacArthur NNP cord-309161-ceahghs1 379 18 studies study NNS cord-309161-ceahghs1 379 19 of of IN cord-309161-ceahghs1 379 20 successful successful JJ cord-309161-ceahghs1 379 21 aging age VBG cord-309161-ceahghs1 379 22 The the DT cord-309161-ceahghs1 379 23 stress stress NN cord-309161-ceahghs1 379 24 of of IN cord-309161-ceahghs1 379 25 life life NN cord-309161-ceahghs1 379 26 Exposure exposure NN cord-309161-ceahghs1 379 27 to to IN cord-309161-ceahghs1 379 28 violence violence NN cord-309161-ceahghs1 379 29 during during IN cord-309161-ceahghs1 379 30 childhood childhood NN cord-309161-ceahghs1 379 31 is be VBZ cord-309161-ceahghs1 379 32 associated associate VBN cord-309161-ceahghs1 379 33 with with IN cord-309161-ceahghs1 379 34 telomere telomere NN cord-309161-ceahghs1 379 35 erosion erosion NN cord-309161-ceahghs1 379 36 from from IN cord-309161-ceahghs1 379 37 5 5 CD cord-309161-ceahghs1 379 38 to to TO cord-309161-ceahghs1 379 39 10 10 CD cord-309161-ceahghs1 379 40 years year NNS cord-309161-ceahghs1 379 41 of of IN cord-309161-ceahghs1 379 42 age age NN cord-309161-ceahghs1 379 43 : : : cord-309161-ceahghs1 380 1 A a DT cord-309161-ceahghs1 380 2 longitudinal longitudinal JJ cord-309161-ceahghs1 380 3 study study NN cord-309161-ceahghs1 380 4 Affective affective JJ cord-309161-ceahghs1 380 5 reactivity reactivity NN cord-309161-ceahghs1 380 6 to to IN cord-309161-ceahghs1 380 7 daily daily JJ cord-309161-ceahghs1 380 8 stressors stressor NNS cord-309161-ceahghs1 380 9 is be VBZ cord-309161-ceahghs1 380 10 associated associate VBN cord-309161-ceahghs1 380 11 with with IN cord-309161-ceahghs1 380 12 elevated elevated JJ cord-309161-ceahghs1 380 13 inflammation inflammation NN cord-309161-ceahghs1 380 14 . . . cord-309161-ceahghs1 381 1 Health health NN cord-309161-ceahghs1 381 2 Psychology psychology NN cord-309161-ceahghs1 381 3 : : : cord-309161-ceahghs1 382 1 Official Official NNP cord-309161-ceahghs1 382 2 Journal Journal NNP cord-309161-ceahghs1 382 3 of of IN cord-309161-ceahghs1 382 4 the the DT cord-309161-ceahghs1 382 5 Division Division NNP cord-309161-ceahghs1 382 6 of of IN cord-309161-ceahghs1 382 7 Health Health NNP cord-309161-ceahghs1 382 8 Psychology Psychology NNP cord-309161-ceahghs1 382 9 Childhood Childhood NNP cord-309161-ceahghs1 382 10 Asthma Asthma NNP cord-309161-ceahghs1 382 11 Prevention Prevention NNP cord-309161-ceahghs1 382 12 Study Study NNP cord-309161-ceahghs1 382 13 group group NN cord-309161-ceahghs1 382 14 Telomere telomere NN cord-309161-ceahghs1 382 15 length length NN cord-309161-ceahghs1 382 16 in in IN cord-309161-ceahghs1 382 17 early early JJ cord-309161-ceahghs1 382 18 childhood childhood NN cord-309161-ceahghs1 382 19 : : : cord-309161-ceahghs1 383 1 Early early JJ cord-309161-ceahghs1 383 2 life life NN cord-309161-ceahghs1 383 3 risk risk NN cord-309161-ceahghs1 383 4 factors factor NNS cord-309161-ceahghs1 383 5 and and CC cord-309161-ceahghs1 383 6 association association NN cord-309161-ceahghs1 383 7 with with IN cord-309161-ceahghs1 383 8 carotid carotid JJ cord-309161-ceahghs1 383 9 intima intima NN cord-309161-ceahghs1 383 10 - - HYPH cord-309161-ceahghs1 383 11 media medium NNS cord-309161-ceahghs1 383 12 thickness thickness NN cord-309161-ceahghs1 383 13 in in IN cord-309161-ceahghs1 383 14 later later JJ cord-309161-ceahghs1 383 15 childhood childhood NN cord-309161-ceahghs1 383 16 Social Social NNP cord-309161-ceahghs1 383 17 Safety Safety NNP cord-309161-ceahghs1 383 18 Theory Theory NNP cord-309161-ceahghs1 383 19 : : : cord-309161-ceahghs1 383 20 A a DT cord-309161-ceahghs1 383 21 Biologically biologically RB cord-309161-ceahghs1 383 22 Based Based NNP cord-309161-ceahghs1 383 23 Evolutionary Evolutionary NNP cord-309161-ceahghs1 383 24 Perspective Perspective NNP cord-309161-ceahghs1 383 25 on on IN cord-309161-ceahghs1 383 26 Life Life NNP cord-309161-ceahghs1 383 27 Stress Stress NNP cord-309161-ceahghs1 383 28 , , , cord-309161-ceahghs1 383 29 Health Health NNP cord-309161-ceahghs1 383 30 , , , cord-309161-ceahghs1 383 31 and and CC cord-309161-ceahghs1 383 32 Behavior Behavior NNP cord-309161-ceahghs1 384 1 Black black JJ cord-309161-ceahghs1 384 2 sheep sheep NNS cord-309161-ceahghs1 384 3 get get VBP cord-309161-ceahghs1 384 4 the the DT cord-309161-ceahghs1 384 5 blues blue NNS cord-309161-ceahghs1 384 6 : : : cord-309161-ceahghs1 384 7 A a DT cord-309161-ceahghs1 384 8 psychobiological psychobiological JJ cord-309161-ceahghs1 384 9 model model NN cord-309161-ceahghs1 384 10 of of IN cord-309161-ceahghs1 384 11 social social JJ cord-309161-ceahghs1 384 12 rejection rejection NN cord-309161-ceahghs1 384 13 and and CC cord-309161-ceahghs1 384 14 depression depression NN cord-309161-ceahghs1 384 15 Childhood Childhood NNP cord-309161-ceahghs1 384 16 adversity adversity NN cord-309161-ceahghs1 384 17 , , , cord-309161-ceahghs1 384 18 adult adult NN cord-309161-ceahghs1 384 19 neighborhood neighborhood NN cord-309161-ceahghs1 384 20 context context NN cord-309161-ceahghs1 384 21 , , , cord-309161-ceahghs1 384 22 and and CC cord-309161-ceahghs1 384 23 cumulative cumulative JJ cord-309161-ceahghs1 384 24 biological biological JJ cord-309161-ceahghs1 384 25 risk risk NN cord-309161-ceahghs1 384 26 for for IN cord-309161-ceahghs1 384 27 chronic chronic JJ cord-309161-ceahghs1 384 28 diseases disease NNS cord-309161-ceahghs1 384 29 in in IN cord-309161-ceahghs1 384 30 adulthood adulthood NN cord-309161-ceahghs1 385 1 Childhood Childhood NNP cord-309161-ceahghs1 385 2 Social Social NNP cord-309161-ceahghs1 385 3 Disadvantage Disadvantage NNP cord-309161-ceahghs1 385 4 and and CC cord-309161-ceahghs1 385 5 Pubertal Pubertal NNP cord-309161-ceahghs1 385 6 Timing timing NN cord-309161-ceahghs1 385 7 : : : cord-309161-ceahghs1 385 8 A a DT cord-309161-ceahghs1 385 9 National National NNP cord-309161-ceahghs1 385 10 Birth Birth NNP cord-309161-ceahghs1 385 11 Cohort Cohort NNP cord-309161-ceahghs1 385 12 From from IN cord-309161-ceahghs1 385 13 Australia Australia NNP cord-309161-ceahghs1 386 1 Life life NN cord-309161-ceahghs1 386 2 Course course NN cord-309161-ceahghs1 386 3 Socioeconomic Socioeconomic NNP cord-309161-ceahghs1 386 4 Status Status NNP cord-309161-ceahghs1 386 5 , , , cord-309161-ceahghs1 386 6 Daily Daily NNP cord-309161-ceahghs1 386 7 Stressors Stressors NNPS cord-309161-ceahghs1 386 8 , , , cord-309161-ceahghs1 386 9 and and CC cord-309161-ceahghs1 386 10 Daily Daily NNP cord-309161-ceahghs1 386 11 Well Well NNP cord-309161-ceahghs1 386 12 - - HYPH cord-309161-ceahghs1 386 13 Being being NN cord-309161-ceahghs1 386 14 : : : cord-309161-ceahghs1 387 1 Examining examine VBG cord-309161-ceahghs1 387 2 Chain Chain NNP cord-309161-ceahghs1 387 3 of of IN cord-309161-ceahghs1 387 4 Risk Risk NNP cord-309161-ceahghs1 387 5 Models Models NNPS cord-309161-ceahghs1 387 6 Experienced experience VBD cord-309161-ceahghs1 387 7 discrimination discrimination NN cord-309161-ceahghs1 387 8 and and CC cord-309161-ceahghs1 387 9 racial racial JJ cord-309161-ceahghs1 387 10 differences difference NNS cord-309161-ceahghs1 387 11 in in IN cord-309161-ceahghs1 387 12 leukocyte leukocyte NN cord-309161-ceahghs1 387 13 gene gene NN cord-309161-ceahghs1 387 14 expression expression NN cord-309161-ceahghs1 387 15 Experience Experience NNP cord-309161-ceahghs1 387 16 Corps Corps NNP cord-309161-ceahghs1 387 17 Baltimore Baltimore NNP cord-309161-ceahghs1 387 18 : : : cord-309161-ceahghs1 387 19 Exploring explore VBG cord-309161-ceahghs1 387 20 the the DT cord-309161-ceahghs1 387 21 Stressors Stressors NNPS cord-309161-ceahghs1 387 22 and and CC cord-309161-ceahghs1 387 23 J J NNP cord-309161-ceahghs1 387 24 o o NN cord-309161-ceahghs1 387 25 u u NN cord-309161-ceahghs1 387 26 r r NN cord-309161-ceahghs1 387 27 n n NN cord-309161-ceahghs1 387 28 a a DT cord-309161-ceahghs1 387 29 l l NN cord-309161-ceahghs1 387 30 P p NN cord-309161-ceahghs1 387 31 r r NN cord-309161-ceahghs1 387 32 e e NN cord-309161-ceahghs1 387 33 -p -p NN cord-309161-ceahghs1 387 34 r r NN cord-309161-ceahghs1 387 35 o o NN cord-309161-ceahghs1 387 36 o o NN cord-309161-ceahghs1 388 1 f f LS cord-309161-ceahghs1 388 2 Rewards Rewards NNPS cord-309161-ceahghs1 388 3 of of IN cord-309161-ceahghs1 388 4 High high JJ cord-309161-ceahghs1 388 5 - - HYPH cord-309161-ceahghs1 388 6 intensity intensity NN cord-309161-ceahghs1 388 7 Civic Civic NNP cord-309161-ceahghs1 388 8 Engagement Engagement NNP cord-309161-ceahghs1 388 9 Heritability Heritability NNP cord-309161-ceahghs1 388 10 of of IN cord-309161-ceahghs1 388 11 personality personality NN cord-309161-ceahghs1 388 12 : : : cord-309161-ceahghs1 388 13 A a DT cord-309161-ceahghs1 388 14 meta meta NN cord-309161-ceahghs1 388 15 - - HYPH cord-309161-ceahghs1 388 16 analysis analysis NN cord-309161-ceahghs1 388 17 of of IN cord-309161-ceahghs1 388 18 behavior behavior NN cord-309161-ceahghs1 388 19 genetic genetic JJ cord-309161-ceahghs1 388 20 studies study NNS cord-309161-ceahghs1 388 21 COVID-19 covid-19 VBP cord-309161-ceahghs1 388 22 and and CC cord-309161-ceahghs1 388 23 Racial Racial NNP cord-309161-ceahghs1 388 24 / / SYM cord-309161-ceahghs1 388 25 Ethnic Ethnic NNP cord-309161-ceahghs1 388 26 Disparities Disparities NNPS cord-309161-ceahghs1 388 27 Physical Physical NNP cord-309161-ceahghs1 388 28 Resilience Resilience NNP cord-309161-ceahghs1 388 29 : : : cord-309161-ceahghs1 389 1 Not not RB cord-309161-ceahghs1 389 2 Simply simply RB cord-309161-ceahghs1 389 3 the the DT cord-309161-ceahghs1 389 4 Opposite Opposite NNP cord-309161-ceahghs1 389 5 of of IN cord-309161-ceahghs1 389 6 Frailty Frailty NNP cord-309161-ceahghs1 389 7 Physical Physical NNP cord-309161-ceahghs1 389 8 Resilience Resilience NNP cord-309161-ceahghs1 389 9 in in IN cord-309161-ceahghs1 389 10 Older old JJR cord-309161-ceahghs1 389 11 Adults Adults NNPS cord-309161-ceahghs1 389 12 : : : cord-309161-ceahghs1 389 13 Systematic systematic JJ cord-309161-ceahghs1 389 14 Review Review NNP cord-309161-ceahghs1 389 15 and and CC cord-309161-ceahghs1 389 16 Development Development NNP cord-309161-ceahghs1 389 17 of of IN cord-309161-ceahghs1 389 18 an an DT cord-309161-ceahghs1 389 19 Emerging emerge VBG cord-309161-ceahghs1 389 20 Construct construct NN cord-309161-ceahghs1 389 21 How how WRB cord-309161-ceahghs1 389 22 adverse adverse JJ cord-309161-ceahghs1 389 23 childhood childhood NN cord-309161-ceahghs1 389 24 experiences experience NNS cord-309161-ceahghs1 389 25 relate relate VBP cord-309161-ceahghs1 389 26 to to IN cord-309161-ceahghs1 389 27 single single JJ cord-309161-ceahghs1 389 28 and and CC cord-309161-ceahghs1 389 29 multiple multiple JJ cord-309161-ceahghs1 389 30 health health NN cord-309161-ceahghs1 389 31 risk risk NN cord-309161-ceahghs1 389 32 behaviours behaviour NNS cord-309161-ceahghs1 389 33 in in IN cord-309161-ceahghs1 389 34 German german JJ cord-309161-ceahghs1 389 35 public public JJ cord-309161-ceahghs1 389 36 university university NN cord-309161-ceahghs1 389 37 students student NNS cord-309161-ceahghs1 389 38 : : : cord-309161-ceahghs1 389 39 A a DT cord-309161-ceahghs1 389 40 crosssectional crosssectional JJ cord-309161-ceahghs1 389 41 analysis analysis NN cord-309161-ceahghs1 389 42 Relationship relationship NN cord-309161-ceahghs1 389 43 of of IN cord-309161-ceahghs1 389 44 Psychosocial Psychosocial NNP cord-309161-ceahghs1 389 45 Resources Resources NNPS cord-309161-ceahghs1 389 46 With with IN cord-309161-ceahghs1 389 47 Allostatic Allostatic NNP cord-309161-ceahghs1 389 48 Load Load NNP cord-309161-ceahghs1 389 49 : : : cord-309161-ceahghs1 389 50 A a DT cord-309161-ceahghs1 389 51 Systematic systematic JJ cord-309161-ceahghs1 389 52 Review review NN cord-309161-ceahghs1 390 1 Traumatic traumatic JJ cord-309161-ceahghs1 390 2 stress stress NN cord-309161-ceahghs1 390 3 and and CC cord-309161-ceahghs1 390 4 accelerated accelerate VBN cord-309161-ceahghs1 390 5 DNA dna NN cord-309161-ceahghs1 390 6 methylation methylation NN cord-309161-ceahghs1 390 7 age age NN cord-309161-ceahghs1 390 8 : : : cord-309161-ceahghs1 391 1 A a DT cord-309161-ceahghs1 391 2 meta meta JJ cord-309161-ceahghs1 391 3 - - HYPH cord-309161-ceahghs1 391 4 analysis analysis NN cord-309161-ceahghs1 391 5 Impact Impact NNP cord-309161-ceahghs1 391 6 of of IN cord-309161-ceahghs1 391 7 COVID-19 COVID-19 NNP cord-309161-ceahghs1 391 8 pandemic pandemic NN cord-309161-ceahghs1 391 9 on on IN cord-309161-ceahghs1 391 10 mental mental JJ cord-309161-ceahghs1 391 11 health health NN cord-309161-ceahghs1 391 12 in in IN cord-309161-ceahghs1 391 13 the the DT cord-309161-ceahghs1 391 14 general general JJ cord-309161-ceahghs1 391 15 population population NN cord-309161-ceahghs1 391 16 : : : cord-309161-ceahghs1 392 1 A a DT cord-309161-ceahghs1 392 2 systematic systematic JJ cord-309161-ceahghs1 392 3 review review NN cord-309161-ceahghs1 393 1 The the DT cord-309161-ceahghs1 393 2 Impact Impact NNP cord-309161-ceahghs1 393 3 of of IN cord-309161-ceahghs1 393 4 Changes Changes NNPS cord-309161-ceahghs1 393 5 in in IN cord-309161-ceahghs1 393 6 Population Population NNP cord-309161-ceahghs1 393 7 Health Health NNP cord-309161-ceahghs1 393 8 and and CC cord-309161-ceahghs1 393 9 Mortality Mortality NNP cord-309161-ceahghs1 393 10 on on IN cord-309161-ceahghs1 393 11 Future future JJ cord-309161-ceahghs1 393 12 Prevalence prevalence NN cord-309161-ceahghs1 393 13 of of IN cord-309161-ceahghs1 393 14 Alzheimer Alzheimer NNP cord-309161-ceahghs1 393 15 's 's POS cord-309161-ceahghs1 393 16 Disease Disease NNP cord-309161-ceahghs1 393 17 and and CC cord-309161-ceahghs1 393 18 Other Other NNP cord-309161-ceahghs1 393 19 Dementias Dementias NNPS cord-309161-ceahghs1 393 20 in in IN cord-309161-ceahghs1 393 21 the the DT cord-309161-ceahghs1 393 22 United United NNP cord-309161-ceahghs1 393 23 States States NNP cord-309161-ceahghs1 393 24 Crimmins Crimmins NNP cord-309161-ceahghs1 393 25 , , , cord-309161-ceahghs1 393 26 Steve Steve NNP cord-309161-ceahghs1 393 27 Austad Austad NNP cord-309161-ceahghs1 393 28 , , , cord-309161-ceahghs1 393 29 and and CC cord-309161-ceahghs1 393 30 Edward Edward NNP cord-309161-ceahghs1 393 31 Calabrese Calabrese NNP cord-309161-ceahghs1 393 32 . . . cord-309161-ceahghs1 393 33 _SP