id	sid	tid	token	lemma	pos
cord-305263-fgwf6wy3	1	1	key	key	JJ
cord-305263-fgwf6wy3	1	2	:	:	:
cord-305263-fgwf6wy3	1	3	cord-305263-fgwf6wy3	cord-305263-fgwf6wy3	JJ
cord-305263-fgwf6wy3	1	4	authors	author	NNS
cord-305263-fgwf6wy3	1	5	:	:	:
cord-305263-fgwf6wy3	1	6	Wang	Wang	NNP
cord-305263-fgwf6wy3	1	7	,	,	,
cord-305263-fgwf6wy3	1	8	Ben	Ben	NNP
cord-305263-fgwf6wy3	1	9	X.	X.	NNP
cord-305263-fgwf6wy3	1	10	;	;	:
cord-305263-fgwf6wy3	1	11	Fish	Fish	NNP
cord-305263-fgwf6wy3	1	12	,	,	,
cord-305263-fgwf6wy3	1	13	Eleanor	Eleanor	NNP
cord-305263-fgwf6wy3	1	14	N.	N.	NNP
cord-305263-fgwf6wy3	1	15	title	title	NN
cord-305263-fgwf6wy3	1	16	:	:	:
cord-305263-fgwf6wy3	2	1	The	the	DT
cord-305263-fgwf6wy3	2	2	yin	yin	NNP
cord-305263-fgwf6wy3	2	3	and	and	CC
cord-305263-fgwf6wy3	2	4	yang	yang	NNP
cord-305263-fgwf6wy3	2	5	of	of	IN
cord-305263-fgwf6wy3	2	6	viruses	virus	NNS
cord-305263-fgwf6wy3	2	7	and	and	CC
cord-305263-fgwf6wy3	2	8	interferons	interferon	NNS
cord-305263-fgwf6wy3	2	9	date	date	NN
cord-305263-fgwf6wy3	2	10	:	:	:
cord-305263-fgwf6wy3	2	11	2012	2012	CD
cord-305263-fgwf6wy3	2	12	-	-	HYPH
cord-305263-fgwf6wy3	2	13	02	02	CD
cord-305263-fgwf6wy3	2	14	-	-	HYPH
cord-305263-fgwf6wy3	2	15	07	07	CD
cord-305263-fgwf6wy3	2	16	journal	journal	NN
cord-305263-fgwf6wy3	2	17	:	:	:
cord-305263-fgwf6wy3	3	1	Trends	trend	NNS
cord-305263-fgwf6wy3	4	1	Immunol	Immunol	NNP
cord-305263-fgwf6wy3	4	2	DOI	doi	NN
cord-305263-fgwf6wy3	4	3	:	:	:
cord-305263-fgwf6wy3	5	1	10.1016	10.1016	CD
cord-305263-fgwf6wy3	6	1	/j.it.2012.01.004	/j.it.2012.01.004	NNP
cord-305263-fgwf6wy3	6	2	sha	sha	NNP
cord-305263-fgwf6wy3	6	3	:	:	:
cord-305263-fgwf6wy3	7	1	cd5b77001b7adf69e87c19dcd3993ccd05a62e27	cd5b77001b7adf69e87c19dcd3993ccd05a62e27	NNP
cord-305263-fgwf6wy3	7	2	doc_id	doc_id	CD
cord-305263-fgwf6wy3	7	3	:	:	:
cord-305263-fgwf6wy3	7	4	305263	305263	CD
cord-305263-fgwf6wy3	7	5	cord_uid	cord_uid	NN
cord-305263-fgwf6wy3	7	6	:	:	:
cord-305263-fgwf6wy3	8	1	fgwf6wy3	fgwf6wy3	CD
cord-305263-fgwf6wy3	8	2	Interferons	interferon	NNS
cord-305263-fgwf6wy3	9	1	(	(	-LRB-
cord-305263-fgwf6wy3	9	2	IFNs)-α	IFNs)-α	NNP
cord-305263-fgwf6wy3	9	3	/	/	SYM
cord-305263-fgwf6wy3	9	4	β	β	NN
cord-305263-fgwf6wy3	9	5	are	be	VBP
cord-305263-fgwf6wy3	9	6	critical	critical	JJ
cord-305263-fgwf6wy3	9	7	effectors	effector	NNS
cord-305263-fgwf6wy3	9	8	of	of	IN
cord-305263-fgwf6wy3	9	9	the	the	DT
cord-305263-fgwf6wy3	9	10	innate	innate	JJ
cord-305263-fgwf6wy3	9	11	immune	immune	JJ
cord-305263-fgwf6wy3	9	12	response	response	NN
cord-305263-fgwf6wy3	9	13	to	to	IN
cord-305263-fgwf6wy3	9	14	virus	virus	NN
cord-305263-fgwf6wy3	9	15	infections	infection	NNS
cord-305263-fgwf6wy3	9	16	.	.	.
cord-305263-fgwf6wy3	10	1	Through	through	IN
cord-305263-fgwf6wy3	10	2	activation	activation	NN
cord-305263-fgwf6wy3	10	3	of	of	IN
cord-305263-fgwf6wy3	10	4	the	the	DT
cord-305263-fgwf6wy3	10	5	IFN	IFN	NNP
cord-305263-fgwf6wy3	10	6	-	-	HYPH
cord-305263-fgwf6wy3	10	7	α	α	NNP
cord-305263-fgwf6wy3	10	8	/	/	SYM
cord-305263-fgwf6wy3	10	9	β	β	NN
cord-305263-fgwf6wy3	10	10	receptor	receptor	NN
cord-305263-fgwf6wy3	10	11	(	(	-LRB-
cord-305263-fgwf6wy3	10	12	IFNAR	IFNAR	NNP
cord-305263-fgwf6wy3	10	13	)	)	-RRB-
cord-305263-fgwf6wy3	10	14	,	,	,
cord-305263-fgwf6wy3	10	15	they	-PRON-	PRP
cord-305263-fgwf6wy3	10	16	induce	induce	VBP
cord-305263-fgwf6wy3	10	17	expression	expression	NN
cord-305263-fgwf6wy3	10	18	of	of	IN
cord-305263-fgwf6wy3	10	19	IFN	IFN	NNP
cord-305263-fgwf6wy3	10	20	-	-	HYPH
cord-305263-fgwf6wy3	10	21	stimulated	stimulate	VBN
cord-305263-fgwf6wy3	10	22	genes	gene	NNS
cord-305263-fgwf6wy3	10	23	(	(	-LRB-
cord-305263-fgwf6wy3	10	24	ISGs	ISGs	NNP
cord-305263-fgwf6wy3	10	25	)	)	-RRB-
cord-305263-fgwf6wy3	10	26	that	that	WDT
cord-305263-fgwf6wy3	10	27	encode	encode	VBP
cord-305263-fgwf6wy3	10	28	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	10	29	proteins	protein	NNS
cord-305263-fgwf6wy3	10	30	capable	capable	JJ
cord-305263-fgwf6wy3	10	31	of	of	IN
cord-305263-fgwf6wy3	10	32	suppressing	suppress	VBG
cord-305263-fgwf6wy3	10	33	viral	viral	JJ
cord-305263-fgwf6wy3	10	34	replication	replication	NN
cord-305263-fgwf6wy3	10	35	and	and	CC
cord-305263-fgwf6wy3	10	36	promoting	promote	VBG
cord-305263-fgwf6wy3	10	37	viral	viral	JJ
cord-305263-fgwf6wy3	10	38	clearance	clearance	NN
cord-305263-fgwf6wy3	10	39	.	.	.
cord-305263-fgwf6wy3	11	1	Many	many	JJ
cord-305263-fgwf6wy3	11	2	highly	highly	RB
cord-305263-fgwf6wy3	11	3	pathogenic	pathogenic	JJ
cord-305263-fgwf6wy3	11	4	viruses	virus	NNS
cord-305263-fgwf6wy3	11	5	have	have	VBP
cord-305263-fgwf6wy3	11	6	evolved	evolve	VBN
cord-305263-fgwf6wy3	11	7	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	11	8	to	to	TO
cord-305263-fgwf6wy3	11	9	evade	evade	VB
cord-305263-fgwf6wy3	11	10	an	an	DT
cord-305263-fgwf6wy3	11	11	IFN	IFN	NNP
cord-305263-fgwf6wy3	11	12	response	response	NN
cord-305263-fgwf6wy3	11	13	and	and	CC
cord-305263-fgwf6wy3	11	14	the	the	DT
cord-305263-fgwf6wy3	11	15	balance	balance	NN
cord-305263-fgwf6wy3	11	16	between	between	IN
cord-305263-fgwf6wy3	11	17	the	the	DT
cord-305263-fgwf6wy3	11	18	robustness	robustness	NN
cord-305263-fgwf6wy3	11	19	of	of	IN
cord-305263-fgwf6wy3	11	20	the	the	DT
cord-305263-fgwf6wy3	11	21	host	host	NN
cord-305263-fgwf6wy3	11	22	immune	immune	JJ
cord-305263-fgwf6wy3	11	23	response	response	NN
cord-305263-fgwf6wy3	11	24	and	and	CC
cord-305263-fgwf6wy3	11	25	viral	viral	JJ
cord-305263-fgwf6wy3	11	26	antagonistic	antagonistic	JJ
cord-305263-fgwf6wy3	11	27	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	11	28	determines	determine	VBZ
cord-305263-fgwf6wy3	11	29	whether	whether	IN
cord-305263-fgwf6wy3	11	30	or	or	CC
cord-305263-fgwf6wy3	11	31	not	not	RB
cord-305263-fgwf6wy3	11	32	the	the	DT
cord-305263-fgwf6wy3	11	33	virus	virus	NN
cord-305263-fgwf6wy3	11	34	is	be	VBZ
cord-305263-fgwf6wy3	11	35	cleared	clear	VBN
cord-305263-fgwf6wy3	11	36	.	.	.
cord-305263-fgwf6wy3	12	1	Here	here	RB
cord-305263-fgwf6wy3	12	2	,	,	,
cord-305263-fgwf6wy3	12	3	we	-PRON-	PRP
cord-305263-fgwf6wy3	12	4	discuss	discuss	VBP
cord-305263-fgwf6wy3	12	5	IFNs	ifn	NNS
cord-305263-fgwf6wy3	12	6	as	as	IN
cord-305263-fgwf6wy3	12	7	broad	broad	JJ
cord-305263-fgwf6wy3	12	8	-	-	HYPH
cord-305263-fgwf6wy3	12	9	spectrum	spectrum	NN
cord-305263-fgwf6wy3	12	10	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	12	11	for	for	IN
cord-305263-fgwf6wy3	12	12	treatment	treatment	NN
cord-305263-fgwf6wy3	12	13	of	of	IN
cord-305263-fgwf6wy3	12	14	acute	acute	JJ
cord-305263-fgwf6wy3	12	15	virus	virus	NN
cord-305263-fgwf6wy3	12	16	infections	infection	NNS
cord-305263-fgwf6wy3	12	17	.	.	.
cord-305263-fgwf6wy3	13	1	In	in	IN
cord-305263-fgwf6wy3	13	2	particular	particular	JJ
cord-305263-fgwf6wy3	13	3	,	,	,
cord-305263-fgwf6wy3	13	4	they	-PRON-	PRP
cord-305263-fgwf6wy3	13	5	are	be	VBP
cord-305263-fgwf6wy3	13	6	useful	useful	JJ
cord-305263-fgwf6wy3	13	7	for	for	IN
cord-305263-fgwf6wy3	13	8	treatment	treatment	NN
cord-305263-fgwf6wy3	13	9	of	of	IN
cord-305263-fgwf6wy3	13	10	re	re	NN
cord-305263-fgwf6wy3	13	11	-	-	JJ
cord-305263-fgwf6wy3	13	12	emerging	emerge	VBG
cord-305263-fgwf6wy3	13	13	virus	virus	NN
cord-305263-fgwf6wy3	13	14	infections	infection	NNS
cord-305263-fgwf6wy3	13	15	,	,	,
cord-305263-fgwf6wy3	13	16	where	where	WRB
cord-305263-fgwf6wy3	13	17	direct	direct	JJ
cord-305263-fgwf6wy3	13	18	-	-	HYPH
cord-305263-fgwf6wy3	13	19	acting	act	VBG
cord-305263-fgwf6wy3	13	20	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	13	21	(	(	-LRB-
cord-305263-fgwf6wy3	13	22	DAAs	DAAs	NNP
cord-305263-fgwf6wy3	13	23	)	)	-RRB-
cord-305263-fgwf6wy3	13	24	have	have	VBP
cord-305263-fgwf6wy3	13	25	limited	limit	VBN
cord-305263-fgwf6wy3	13	26	utility	utility	NN
cord-305263-fgwf6wy3	13	27	due	due	IN
cord-305263-fgwf6wy3	13	28	to	to	IN
cord-305263-fgwf6wy3	13	29	DAA	DAA	NNP
cord-305263-fgwf6wy3	13	30	-	-	HYPH
cord-305263-fgwf6wy3	13	31	resistant	resistant	JJ
cord-305263-fgwf6wy3	13	32	mutations	mutation	NNS
cord-305263-fgwf6wy3	13	33	,	,	,
cord-305263-fgwf6wy3	13	34	and	and	CC
cord-305263-fgwf6wy3	13	35	for	for	IN
cord-305263-fgwf6wy3	13	36	newly	newly	RB
cord-305263-fgwf6wy3	13	37	emerging	emerge	VBG
cord-305263-fgwf6wy3	13	38	virus	virus	NN
cord-305263-fgwf6wy3	13	39	strains	strain	NNS
cord-305263-fgwf6wy3	13	40	in	in	IN
cord-305263-fgwf6wy3	13	41	which	which	WDT
cord-305263-fgwf6wy3	13	42	the	the	DT
cord-305263-fgwf6wy3	13	43	time	time	NN
cord-305263-fgwf6wy3	13	44	to	to	IN
cord-305263-fgwf6wy3	13	45	vaccine	vaccine	NN
cord-305263-fgwf6wy3	13	46	availability	availability	NN
cord-305263-fgwf6wy3	13	47	precludes	preclude	VBZ
cord-305263-fgwf6wy3	13	48	vaccination	vaccination	NN
cord-305263-fgwf6wy3	13	49	at	at	IN
cord-305263-fgwf6wy3	13	50	the	the	DT
cord-305263-fgwf6wy3	13	51	onset	onset	NN
cord-305263-fgwf6wy3	13	52	of	of	IN
cord-305263-fgwf6wy3	13	53	an	an	DT
cord-305263-fgwf6wy3	13	54	outbreak	outbreak	NN
cord-305263-fgwf6wy3	13	55	.	.	.
cord-305263-fgwf6wy3	14	1	Interferons	interferon	NNS
cord-305263-fgwf6wy3	14	2	(	(	-LRB-
cord-305263-fgwf6wy3	14	3	IFNs)-a	ifns)-a	NN
cord-305263-fgwf6wy3	14	4	/	/	SYM
cord-305263-fgwf6wy3	14	5	b	b	NN
cord-305263-fgwf6wy3	14	6	are	be	VBP
cord-305263-fgwf6wy3	14	7	critical	critical	JJ
cord-305263-fgwf6wy3	14	8	effectors	effector	NNS
cord-305263-fgwf6wy3	14	9	of	of	IN
cord-305263-fgwf6wy3	14	10	the	the	DT
cord-305263-fgwf6wy3	14	11	innate	innate	JJ
cord-305263-fgwf6wy3	14	12	immune	immune	JJ
cord-305263-fgwf6wy3	14	13	response	response	NN
cord-305263-fgwf6wy3	14	14	to	to	IN
cord-305263-fgwf6wy3	14	15	virus	virus	NN
cord-305263-fgwf6wy3	14	16	infections	infection	NNS
cord-305263-fgwf6wy3	14	17	.	.	.
cord-305263-fgwf6wy3	15	1	Through	through	IN
cord-305263-fgwf6wy3	15	2	activation	activation	NN
cord-305263-fgwf6wy3	15	3	of	of	IN
cord-305263-fgwf6wy3	15	4	the	the	DT
cord-305263-fgwf6wy3	15	5	IFN	IFN	NNP
cord-305263-fgwf6wy3	15	6	-	-	HYPH
cord-305263-fgwf6wy3	15	7	a	a	NNP
cord-305263-fgwf6wy3	15	8	/	/	SYM
cord-305263-fgwf6wy3	15	9	b	b	NN
cord-305263-fgwf6wy3	15	10	receptor	receptor	NN
cord-305263-fgwf6wy3	15	11	(	(	-LRB-
cord-305263-fgwf6wy3	15	12	IFNAR	IFNAR	NNP
cord-305263-fgwf6wy3	15	13	)	)	-RRB-
cord-305263-fgwf6wy3	15	14	,	,	,
cord-305263-fgwf6wy3	15	15	they	-PRON-	PRP
cord-305263-fgwf6wy3	15	16	induce	induce	VBP
cord-305263-fgwf6wy3	15	17	expression	expression	NN
cord-305263-fgwf6wy3	15	18	of	of	IN
cord-305263-fgwf6wy3	15	19	IFN	IFN	NNP
cord-305263-fgwf6wy3	15	20	-	-	HYPH
cord-305263-fgwf6wy3	15	21	stimulated	stimulate	VBN
cord-305263-fgwf6wy3	15	22	genes	gene	NNS
cord-305263-fgwf6wy3	15	23	(	(	-LRB-
cord-305263-fgwf6wy3	15	24	ISGs	ISGs	NNP
cord-305263-fgwf6wy3	15	25	)	)	-RRB-
cord-305263-fgwf6wy3	15	26	that	that	WDT
cord-305263-fgwf6wy3	15	27	encode	encode	VBP
cord-305263-fgwf6wy3	15	28	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	15	29	proteins	protein	NNS
cord-305263-fgwf6wy3	15	30	capable	capable	JJ
cord-305263-fgwf6wy3	15	31	of	of	IN
cord-305263-fgwf6wy3	15	32	suppressing	suppress	VBG
cord-305263-fgwf6wy3	15	33	viral	viral	JJ
cord-305263-fgwf6wy3	15	34	replication	replication	NN
cord-305263-fgwf6wy3	15	35	and	and	CC
cord-305263-fgwf6wy3	15	36	promoting	promote	VBG
cord-305263-fgwf6wy3	15	37	viral	viral	JJ
cord-305263-fgwf6wy3	15	38	clearance	clearance	NN
cord-305263-fgwf6wy3	15	39	.	.	.
cord-305263-fgwf6wy3	16	1	Many	many	JJ
cord-305263-fgwf6wy3	16	2	highly	highly	RB
cord-305263-fgwf6wy3	16	3	pathogenic	pathogenic	JJ
cord-305263-fgwf6wy3	16	4	viruses	virus	NNS
cord-305263-fgwf6wy3	16	5	have	have	VBP
cord-305263-fgwf6wy3	16	6	evolved	evolve	VBN
cord-305263-fgwf6wy3	16	7	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	16	8	to	to	TO
cord-305263-fgwf6wy3	16	9	evade	evade	VB
cord-305263-fgwf6wy3	16	10	an	an	DT
cord-305263-fgwf6wy3	16	11	IFN	IFN	NNP
cord-305263-fgwf6wy3	16	12	response	response	NN
cord-305263-fgwf6wy3	16	13	and	and	CC
cord-305263-fgwf6wy3	16	14	the	the	DT
cord-305263-fgwf6wy3	16	15	balance	balance	NN
cord-305263-fgwf6wy3	16	16	between	between	IN
cord-305263-fgwf6wy3	16	17	the	the	DT
cord-305263-fgwf6wy3	16	18	robustness	robustness	NN
cord-305263-fgwf6wy3	16	19	of	of	IN
cord-305263-fgwf6wy3	16	20	the	the	DT
cord-305263-fgwf6wy3	16	21	host	host	NN
cord-305263-fgwf6wy3	16	22	immune	immune	JJ
cord-305263-fgwf6wy3	16	23	response	response	NN
cord-305263-fgwf6wy3	16	24	and	and	CC
cord-305263-fgwf6wy3	16	25	viral	viral	JJ
cord-305263-fgwf6wy3	16	26	antagonistic	antagonistic	JJ
cord-305263-fgwf6wy3	16	27	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	16	28	determines	determine	VBZ
cord-305263-fgwf6wy3	16	29	whether	whether	IN
cord-305263-fgwf6wy3	16	30	or	or	CC
cord-305263-fgwf6wy3	16	31	not	not	RB
cord-305263-fgwf6wy3	16	32	the	the	DT
cord-305263-fgwf6wy3	16	33	virus	virus	NN
cord-305263-fgwf6wy3	16	34	is	be	VBZ
cord-305263-fgwf6wy3	16	35	cleared	clear	VBN
cord-305263-fgwf6wy3	16	36	.	.	.
cord-305263-fgwf6wy3	17	1	Here	here	RB
cord-305263-fgwf6wy3	17	2	,	,	,
cord-305263-fgwf6wy3	17	3	we	-PRON-	PRP
cord-305263-fgwf6wy3	17	4	discuss	discuss	VBP
cord-305263-fgwf6wy3	17	5	IFNs	ifn	NNS
cord-305263-fgwf6wy3	17	6	as	as	IN
cord-305263-fgwf6wy3	17	7	broad	broad	JJ
cord-305263-fgwf6wy3	17	8	-	-	HYPH
cord-305263-fgwf6wy3	17	9	spectrum	spectrum	NN
cord-305263-fgwf6wy3	17	10	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	17	11	for	for	IN
cord-305263-fgwf6wy3	17	12	treatment	treatment	NN
cord-305263-fgwf6wy3	17	13	of	of	IN
cord-305263-fgwf6wy3	17	14	acute	acute	JJ
cord-305263-fgwf6wy3	17	15	virus	virus	NN
cord-305263-fgwf6wy3	17	16	infections	infection	NNS
cord-305263-fgwf6wy3	17	17	.	.	.
cord-305263-fgwf6wy3	18	1	In	in	IN
cord-305263-fgwf6wy3	18	2	particular	particular	JJ
cord-305263-fgwf6wy3	18	3	,	,	,
cord-305263-fgwf6wy3	18	4	they	-PRON-	PRP
cord-305263-fgwf6wy3	18	5	are	be	VBP
cord-305263-fgwf6wy3	18	6	useful	useful	JJ
cord-305263-fgwf6wy3	18	7	for	for	IN
cord-305263-fgwf6wy3	18	8	treatment	treatment	NN
cord-305263-fgwf6wy3	18	9	of	of	IN
cord-305263-fgwf6wy3	18	10	re	re	NN
cord-305263-fgwf6wy3	18	11	-	-	JJ
cord-305263-fgwf6wy3	18	12	emerging	emerge	VBG
cord-305263-fgwf6wy3	18	13	virus	virus	NN
cord-305263-fgwf6wy3	18	14	infections	infection	NNS
cord-305263-fgwf6wy3	18	15	,	,	,
cord-305263-fgwf6wy3	18	16	where	where	WRB
cord-305263-fgwf6wy3	18	17	direct	direct	JJ
cord-305263-fgwf6wy3	18	18	-	-	HYPH
cord-305263-fgwf6wy3	18	19	acting	act	VBG
cord-305263-fgwf6wy3	18	20	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	18	21	(	(	-LRB-
cord-305263-fgwf6wy3	18	22	DAAs	DAAs	NNP
cord-305263-fgwf6wy3	18	23	)	)	-RRB-
cord-305263-fgwf6wy3	18	24	have	have	VBP
cord-305263-fgwf6wy3	18	25	limited	limit	VBN
cord-305263-fgwf6wy3	18	26	utility	utility	NN
cord-305263-fgwf6wy3	18	27	due	due	IN
cord-305263-fgwf6wy3	18	28	to	to	IN
cord-305263-fgwf6wy3	18	29	DAA	DAA	NNP
cord-305263-fgwf6wy3	18	30	-	-	HYPH
cord-305263-fgwf6wy3	18	31	resistant	resistant	JJ
cord-305263-fgwf6wy3	18	32	mutations	mutation	NNS
cord-305263-fgwf6wy3	18	33	,	,	,
cord-305263-fgwf6wy3	18	34	and	and	CC
cord-305263-fgwf6wy3	18	35	for	for	IN
cord-305263-fgwf6wy3	18	36	newly	newly	RB
cord-305263-fgwf6wy3	18	37	emerging	emerge	VBG
cord-305263-fgwf6wy3	18	38	virus	virus	NN
cord-305263-fgwf6wy3	18	39	strains	strain	NNS
cord-305263-fgwf6wy3	18	40	in	in	IN
cord-305263-fgwf6wy3	18	41	which	which	WDT
cord-305263-fgwf6wy3	18	42	the	the	DT
cord-305263-fgwf6wy3	18	43	time	time	NN
cord-305263-fgwf6wy3	18	44	to	to	IN
cord-305263-fgwf6wy3	18	45	vaccine	vaccine	NN
cord-305263-fgwf6wy3	18	46	availability	availability	NN
cord-305263-fgwf6wy3	18	47	precludes	preclude	VBZ
cord-305263-fgwf6wy3	18	48	vaccination	vaccination	NN
cord-305263-fgwf6wy3	18	49	at	at	IN
cord-305263-fgwf6wy3	18	50	the	the	DT
cord-305263-fgwf6wy3	18	51	onset	onset	NN
cord-305263-fgwf6wy3	18	52	of	of	IN
cord-305263-fgwf6wy3	18	53	an	an	DT
cord-305263-fgwf6wy3	18	54	outbreak	outbreak	NN
cord-305263-fgwf6wy3	18	55	.	.	.
cord-305263-fgwf6wy3	19	1	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	19	2	-	-	:
cord-305263-fgwf6wy3	19	3	a	a	NN
cord-305263-fgwf6wy3	19	4	/	/	SYM
cord-305263-fgwf6wy3	19	5	b	b	NN
cord-305263-fgwf6wy3	19	6	:	:	:
cord-305263-fgwf6wy3	19	7	host	host	NN
cord-305263-fgwf6wy3	19	8	-	-	HYPH
cord-305263-fgwf6wy3	19	9	derived	derive	VBN
cord-305263-fgwf6wy3	19	10	broad	broad	JJ
cord-305263-fgwf6wy3	19	11	spectrum	spectrum	NN
cord-305263-fgwf6wy3	19	12	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	20	1	Virus	virus	NN
cord-305263-fgwf6wy3	20	2	infections	infection	NNS
cord-305263-fgwf6wy3	20	3	range	range	VBP
cord-305263-fgwf6wy3	20	4	from	from	IN
cord-305263-fgwf6wy3	20	5	mild	mild	JJ
cord-305263-fgwf6wy3	20	6	and	and	CC
cord-305263-fgwf6wy3	20	7	benign	benign	JJ
cord-305263-fgwf6wy3	20	8	to	to	IN
cord-305263-fgwf6wy3	20	9	highly	highly	RB
cord-305263-fgwf6wy3	20	10	virulent	virulent	JJ
cord-305263-fgwf6wy3	20	11	epidemics	epidemic	NNS
cord-305263-fgwf6wy3	20	12	and	and	CC
cord-305263-fgwf6wy3	20	13	pandemics	pandemic	NNS
cord-305263-fgwf6wy3	20	14	,	,	,
cord-305263-fgwf6wy3	20	15	and	and	CC
cord-305263-fgwf6wy3	20	16	significantly	significantly	RB
cord-305263-fgwf6wy3	20	17	affect	affect	VB
cord-305263-fgwf6wy3	20	18	global	global	JJ
cord-305263-fgwf6wy3	20	19	health	health	NN
cord-305263-fgwf6wy3	20	20	.	.	.
cord-305263-fgwf6wy3	21	1	DAAs	DAAs	NNP
cord-305263-fgwf6wy3	21	2	,	,	,
cord-305263-fgwf6wy3	21	3	which	which	WDT
cord-305263-fgwf6wy3	21	4	target	target	VBP
cord-305263-fgwf6wy3	21	5	specific	specific	JJ
cord-305263-fgwf6wy3	21	6	steps	step	NNS
cord-305263-fgwf6wy3	21	7	of	of	IN
cord-305263-fgwf6wy3	21	8	virus	virus	NN
cord-305263-fgwf6wy3	21	9	replication	replication	NN
cord-305263-fgwf6wy3	21	10	,	,	,
cord-305263-fgwf6wy3	21	11	and	and	CC
cord-305263-fgwf6wy3	21	12	vaccines	vaccine	NNS
cord-305263-fgwf6wy3	21	13	,	,	,
cord-305263-fgwf6wy3	21	14	are	be	VBP
cord-305263-fgwf6wy3	21	15	currently	currently	RB
cord-305263-fgwf6wy3	21	16	the	the	DT
cord-305263-fgwf6wy3	21	17	most	most	RBS
cord-305263-fgwf6wy3	21	18	effective	effective	JJ
cord-305263-fgwf6wy3	21	19	therapeutic	therapeutic	JJ
cord-305263-fgwf6wy3	21	20	intervention	intervention	NN
cord-305263-fgwf6wy3	21	21	strategies	strategy	NNS
cord-305263-fgwf6wy3	21	22	used	use	VBN
cord-305263-fgwf6wy3	21	23	against	against	IN
cord-305263-fgwf6wy3	21	24	virus	virus	NN
cord-305263-fgwf6wy3	21	25	infections	infection	NNS
cord-305263-fgwf6wy3	21	26	.	.	.
cord-305263-fgwf6wy3	22	1	Newly	newly	RB
cord-305263-fgwf6wy3	22	2	emerging	emerge	VBG
cord-305263-fgwf6wy3	22	3	or	or	CC
cord-305263-fgwf6wy3	22	4	re	re	VBP
cord-305263-fgwf6wy3	22	5	-	-	JJ
cord-305263-fgwf6wy3	22	6	emerging	emerge	VBG
cord-305263-fgwf6wy3	22	7	viruses	virus	NNS
cord-305263-fgwf6wy3	22	8	that	that	WDT
cord-305263-fgwf6wy3	22	9	have	have	VBP
cord-305263-fgwf6wy3	22	10	undergone	undergo	VBN
cord-305263-fgwf6wy3	22	11	mutations	mutation	NNS
cord-305263-fgwf6wy3	22	12	may	may	MD
cord-305263-fgwf6wy3	22	13	,	,	,
cord-305263-fgwf6wy3	22	14	however	however	RB
cord-305263-fgwf6wy3	22	15	,	,	,
cord-305263-fgwf6wy3	22	16	be	be	VB
cord-305263-fgwf6wy3	22	17	resistant	resistant	JJ
cord-305263-fgwf6wy3	22	18	to	to	IN
cord-305263-fgwf6wy3	22	19	the	the	DT
cord-305263-fgwf6wy3	22	20	effects	effect	NNS
cord-305263-fgwf6wy3	22	21	of	of	IN
cord-305263-fgwf6wy3	22	22	DAAs	daa	NNS
cord-305263-fgwf6wy3	22	23	,	,	,
cord-305263-fgwf6wy3	22	24	whereas	whereas	IN
cord-305263-fgwf6wy3	22	25	vaccines	vaccine	NNS
cord-305263-fgwf6wy3	22	26	require	require	VBP
cord-305263-fgwf6wy3	22	27	that	that	IN
cord-305263-fgwf6wy3	22	28	the	the	DT
cord-305263-fgwf6wy3	22	29	virus	virus	NN
cord-305263-fgwf6wy3	22	30	strain	strain	NN
cord-305263-fgwf6wy3	22	31	be	be	VB
cord-305263-fgwf6wy3	22	32	identified	identify	VBN
cord-305263-fgwf6wy3	22	33	before	before	IN
cord-305263-fgwf6wy3	22	34	vaccine	vaccine	NN
cord-305263-fgwf6wy3	22	35	production	production	NN
cord-305263-fgwf6wy3	22	36	,	,	,
cord-305263-fgwf6wy3	22	37	precluding	preclude	VBG
cord-305263-fgwf6wy3	22	38	their	-PRON-	PRP$
cord-305263-fgwf6wy3	22	39	use	use	NN
cord-305263-fgwf6wy3	22	40	at	at	IN
cord-305263-fgwf6wy3	22	41	the	the	DT
cord-305263-fgwf6wy3	22	42	onset	onset	NN
cord-305263-fgwf6wy3	22	43	of	of	IN
cord-305263-fgwf6wy3	22	44	any	any	DT
cord-305263-fgwf6wy3	22	45	new	new	JJ
cord-305263-fgwf6wy3	22	46	virus	virus	NN
cord-305263-fgwf6wy3	22	47	infection	infection	NN
cord-305263-fgwf6wy3	22	48	outbreak	outbreak	NN
cord-305263-fgwf6wy3	22	49	.	.	.
cord-305263-fgwf6wy3	23	1	Broad	broad	JJ
cord-305263-fgwf6wy3	23	2	-	-	HYPH
cord-305263-fgwf6wy3	23	3	spectrum	spectrum	NN
cord-305263-fgwf6wy3	23	4	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	23	5	,	,	,
cord-305263-fgwf6wy3	23	6	capable	capable	JJ
cord-305263-fgwf6wy3	23	7	of	of	IN
cord-305263-fgwf6wy3	23	8	modulating	modulate	VBG
cord-305263-fgwf6wy3	23	9	the	the	DT
cord-305263-fgwf6wy3	23	10	innate	innate	JJ
cord-305263-fgwf6wy3	23	11	immune	immune	JJ
cord-305263-fgwf6wy3	23	12	response	response	NN
cord-305263-fgwf6wy3	23	13	regardless	regardless	RB
cord-305263-fgwf6wy3	23	14	of	of	IN
cord-305263-fgwf6wy3	23	15	the	the	DT
cord-305263-fgwf6wy3	23	16	infecting	infect	VBG
cord-305263-fgwf6wy3	23	17	virus	virus	NN
cord-305263-fgwf6wy3	23	18	,	,	,
cord-305263-fgwf6wy3	23	19	present	present	JJ
cord-305263-fgwf6wy3	23	20	as	as	IN
cord-305263-fgwf6wy3	23	21	ideal	ideal	JJ
cord-305263-fgwf6wy3	23	22	candidates	candidate	NNS
cord-305263-fgwf6wy3	23	23	as	as	IN
cord-305263-fgwf6wy3	23	24	a	a	DT
cord-305263-fgwf6wy3	23	25	first	first	JJ
cord-305263-fgwf6wy3	23	26	-	-	HYPH
cord-305263-fgwf6wy3	23	27	line	line	NN
cord-305263-fgwf6wy3	23	28	treatment	treatment	NN
cord-305263-fgwf6wy3	23	29	for	for	IN
cord-305263-fgwf6wy3	23	30	acute	acute	JJ
cord-305263-fgwf6wy3	23	31	virus	virus	NN
cord-305263-fgwf6wy3	23	32	infections	infection	NNS
cord-305263-fgwf6wy3	23	33	such	such	JJ
cord-305263-fgwf6wy3	23	34	as	as	IN
cord-305263-fgwf6wy3	23	35	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	23	36	tract	tract	NN
cord-305263-fgwf6wy3	23	37	or	or	CC
cord-305263-fgwf6wy3	23	38	sexually	sexually	RB
cord-305263-fgwf6wy3	23	39	transmitted	transmit	VBN
cord-305263-fgwf6wy3	23	40	infections	infection	NNS
cord-305263-fgwf6wy3	23	41	.	.	.
cord-305263-fgwf6wy3	24	1	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	24	2	-	-	:
cord-305263-fgwf6wy3	24	3	a	a	NN
cord-305263-fgwf6wy3	24	4	/	/	SYM
cord-305263-fgwf6wy3	24	5	b	b	NN
cord-305263-fgwf6wy3	24	6	are	be	VBP
cord-305263-fgwf6wy3	24	7	produced	produce	VBN
cord-305263-fgwf6wy3	24	8	by	by	IN
cord-305263-fgwf6wy3	24	9	plasmacytoid	plasmacytoid	NNP
cord-305263-fgwf6wy3	24	10	dendritic	dendritic	JJ
cord-305263-fgwf6wy3	24	11	cells	cell	NNS
cord-305263-fgwf6wy3	24	12	(	(	-LRB-
cord-305263-fgwf6wy3	24	13	pDCs	pDCs	NNP
cord-305263-fgwf6wy3	24	14	)	)	-RRB-
cord-305263-fgwf6wy3	24	15	,	,	,
cord-305263-fgwf6wy3	24	16	macrophages	macrophage	NNS
cord-305263-fgwf6wy3	24	17	,	,	,
cord-305263-fgwf6wy3	24	18	fibroblasts	fibroblast	NNS
cord-305263-fgwf6wy3	24	19	and	and	CC
cord-305263-fgwf6wy3	24	20	endothelial	endothelial	JJ
cord-305263-fgwf6wy3	24	21	cells	cell	NNS
cord-305263-fgwf6wy3	24	22	,	,	,
cord-305263-fgwf6wy3	24	23	and	and	CC
cord-305263-fgwf6wy3	24	24	are	be	VBP
cord-305263-fgwf6wy3	24	25	critical	critical	JJ
cord-305263-fgwf6wy3	24	26	effectors	effector	NNS
cord-305263-fgwf6wy3	24	27	in	in	IN
cord-305263-fgwf6wy3	24	28	an	an	DT
cord-305263-fgwf6wy3	24	29	innate	innate	JJ
cord-305263-fgwf6wy3	24	30	immune	immune	JJ
cord-305263-fgwf6wy3	24	31	response	response	NN
cord-305263-fgwf6wy3	24	32	to	to	IN
cord-305263-fgwf6wy3	24	33	virus	virus	NN
cord-305263-fgwf6wy3	24	34	infections	infection	NNS
cord-305263-fgwf6wy3	24	35	[	[	-LRB-
cord-305263-fgwf6wy3	24	36	1	1	CD
cord-305263-fgwf6wy3	24	37	]	]	-RRB-
cord-305263-fgwf6wy3	24	38	.	.	.
cord-305263-fgwf6wy3	25	1	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	25	2	-	-	:
cord-305263-fgwf6wy3	25	3	a	a	NN
cord-305263-fgwf6wy3	25	4	/	/	SYM
cord-305263-fgwf6wy3	25	5	b	b	NN
cord-305263-fgwf6wy3	25	6	are	be	VBP
cord-305263-fgwf6wy3	25	7	induced	induce	VBN
cord-305263-fgwf6wy3	25	8	following	follow	VBG
cord-305263-fgwf6wy3	25	9	pattern	pattern	NN
cord-305263-fgwf6wy3	25	10	recognition	recognition	NN
cord-305263-fgwf6wy3	25	11	receptor	receptor	NN
cord-305263-fgwf6wy3	25	12	(	(	-LRB-
cord-305263-fgwf6wy3	25	13	PRR	PRR	NNP
cord-305263-fgwf6wy3	25	14	)	)	-RRB-
cord-305263-fgwf6wy3	25	15	activation	activation	NN
cord-305263-fgwf6wy3	25	16	by	by	IN
cord-305263-fgwf6wy3	25	17	viruses	virus	NNS
cord-305263-fgwf6wy3	25	18	(	(	-LRB-
cord-305263-fgwf6wy3	25	19	Box	Box	NNP
cord-305263-fgwf6wy3	25	20	1	1	CD
cord-305263-fgwf6wy3	25	21	,	,	,
cord-305263-fgwf6wy3	25	22	as	as	IN
cord-305263-fgwf6wy3	25	23	reviewed	review	VBN
cord-305263-fgwf6wy3	25	24	in	in	IN
cord-305263-fgwf6wy3	25	25	[	[	-LRB-
cord-305263-fgwf6wy3	25	26	2	2	CD
cord-305263-fgwf6wy3	25	27	]	]	-RRB-
cord-305263-fgwf6wy3	25	28	)	)	-RRB-
cord-305263-fgwf6wy3	25	29	and	and	CC
cord-305263-fgwf6wy3	25	30	target	target	VB
cord-305263-fgwf6wy3	25	31	many	many	JJ
cord-305263-fgwf6wy3	25	32	different	different	JJ
cord-305263-fgwf6wy3	25	33	stages	stage	NNS
cord-305263-fgwf6wy3	25	34	of	of	IN
cord-305263-fgwf6wy3	25	35	viral	viral	JJ
cord-305263-fgwf6wy3	25	36	replication	replication	NN
cord-305263-fgwf6wy3	25	37	:	:	:
cord-305263-fgwf6wy3	25	38	for	for	IN
cord-305263-fgwf6wy3	25	39	example	example	NN
cord-305263-fgwf6wy3	25	40	,	,	,
cord-305263-fgwf6wy3	25	41	viral	viral	JJ
cord-305263-fgwf6wy3	25	42	entry	entry	NN
cord-305263-fgwf6wy3	25	43	,	,	,
cord-305263-fgwf6wy3	25	44	envelope	envelope	NN
cord-305263-fgwf6wy3	25	45	uncoating	uncoating	NN
cord-305263-fgwf6wy3	25	46	,	,	,
cord-305263-fgwf6wy3	25	47	genome	genome	NN
cord-305263-fgwf6wy3	25	48	replication	replication	NN
cord-305263-fgwf6wy3	25	49	,	,	,
cord-305263-fgwf6wy3	25	50	protein	protein	NN
cord-305263-fgwf6wy3	25	51	assembly	assembly	NN
cord-305263-fgwf6wy3	25	52	,	,	,
cord-305263-fgwf6wy3	25	53	and	and	CC
cord-305263-fgwf6wy3	25	54	release	release	NN
cord-305263-fgwf6wy3	25	55	of	of	IN
cord-305263-fgwf6wy3	25	56	viral	viral	JJ
cord-305263-fgwf6wy3	25	57	progeny	progeny	NN
cord-305263-fgwf6wy3	25	58	[	[	-LRB-
cord-305263-fgwf6wy3	25	59	3	3	CD
cord-305263-fgwf6wy3	25	60	,	,	,
cord-305263-fgwf6wy3	25	61	4	4	CD
cord-305263-fgwf6wy3	25	62	]	]	-RRB-
cord-305263-fgwf6wy3	25	63	.	.	.
cord-305263-fgwf6wy3	26	1	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	26	2	-	-	:
cord-305263-fgwf6wy3	26	3	a	a	NN
cord-305263-fgwf6wy3	26	4	/	/	SYM
cord-305263-fgwf6wy3	26	5	b	b	NN
cord-305263-fgwf6wy3	26	6	also	also	RB
cord-305263-fgwf6wy3	26	7	activate	activate	VB
cord-305263-fgwf6wy3	26	8	different	different	JJ
cord-305263-fgwf6wy3	26	9	cell	cell	NN
cord-305263-fgwf6wy3	26	10	types	type	NNS
cord-305263-fgwf6wy3	26	11	in	in	IN
cord-305263-fgwf6wy3	26	12	the	the	DT
cord-305263-fgwf6wy3	26	13	immune	immune	JJ
cord-305263-fgwf6wy3	26	14	system	system	NN
cord-305263-fgwf6wy3	26	15	to	to	TO
cord-305263-fgwf6wy3	26	16	promote	promote	VB
cord-305263-fgwf6wy3	26	17	viral	viral	JJ
cord-305263-fgwf6wy3	26	18	clearance	clearance	NN
cord-305263-fgwf6wy3	26	19	and	and	CC
cord-305263-fgwf6wy3	26	20	induce	induce	VB
cord-305263-fgwf6wy3	26	21	apoptosis	apoptosis	NN
cord-305263-fgwf6wy3	26	22	of	of	IN
cord-305263-fgwf6wy3	26	23	cells	cell	NNS
cord-305263-fgwf6wy3	26	24	to	to	TO
cord-305263-fgwf6wy3	26	25	prevent	prevent	VB
cord-305263-fgwf6wy3	26	26	viral	viral	JJ
cord-305263-fgwf6wy3	26	27	replication	replication	NN
cord-305263-fgwf6wy3	26	28	[	[	-LRB-
cord-305263-fgwf6wy3	26	29	1	1	CD
cord-305263-fgwf6wy3	26	30	,	,	,
cord-305263-fgwf6wy3	26	31	3	3	CD
cord-305263-fgwf6wy3	26	32	]	]	-RRB-
cord-305263-fgwf6wy3	26	33	.	.	.
cord-305263-fgwf6wy3	27	1	As	as	IN
cord-305263-fgwf6wy3	27	2	host	host	NN
cord-305263-fgwf6wy3	27	3	-	-	HYPH
cord-305263-fgwf6wy3	27	4	derived	derive	VBN
cord-305263-fgwf6wy3	27	5	innate	innate	JJ
cord-305263-fgwf6wy3	27	6	immune	immune	JJ
cord-305263-fgwf6wy3	27	7	response	response	NN
cord-305263-fgwf6wy3	27	8	factors	factor	NNS
cord-305263-fgwf6wy3	27	9	,	,	,
cord-305263-fgwf6wy3	27	10	IFNs	ifn	NNS
cord-305263-fgwf6wy3	27	11	are	be	VBP
cord-305263-fgwf6wy3	27	12	,	,	,
cord-305263-fgwf6wy3	27	13	therefore	therefore	RB
cord-305263-fgwf6wy3	27	14	,	,	,
cord-305263-fgwf6wy3	27	15	broad	broad	JJ
cord-305263-fgwf6wy3	27	16	-	-	HYPH
cord-305263-fgwf6wy3	27	17	spectrum	spectrum	NN
cord-305263-fgwf6wy3	27	18	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	27	19	,	,	,
cord-305263-fgwf6wy3	27	20	crucial	crucial	JJ
cord-305263-fgwf6wy3	27	21	for	for	IN
cord-305263-fgwf6wy3	27	22	the	the	DT
cord-305263-fgwf6wy3	27	23	primary	primary	JJ
cord-305263-fgwf6wy3	27	24	host	host	NN
cord-305263-fgwf6wy3	27	25	response	response	NN
cord-305263-fgwf6wy3	27	26	to	to	IN
cord-305263-fgwf6wy3	27	27	viral	viral	JJ
cord-305263-fgwf6wy3	27	28	infection	infection	NN
cord-305263-fgwf6wy3	27	29	.	.	.
cord-305263-fgwf6wy3	28	1	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	28	2	-	-	:
cord-305263-fgwf6wy3	28	3	a	a	NN
cord-305263-fgwf6wy3	28	4	/	/	SYM
cord-305263-fgwf6wy3	28	5	b	b	TO
cord-305263-fgwf6wy3	28	6	bind	bind	VB
cord-305263-fgwf6wy3	28	7	to	to	IN
cord-305263-fgwf6wy3	28	8	and	and	CC
cord-305263-fgwf6wy3	28	9	activate	activate	VB
cord-305263-fgwf6wy3	28	10	the	the	DT
cord-305263-fgwf6wy3	28	11	IFNAR	IFNAR	NNP
cord-305263-fgwf6wy3	28	12	complex	complex	NN
cord-305263-fgwf6wy3	28	13	,	,	,
cord-305263-fgwf6wy3	28	14	resulting	result	VBG
cord-305263-fgwf6wy3	28	15	in	in	IN
cord-305263-fgwf6wy3	28	16	the	the	DT
cord-305263-fgwf6wy3	28	17	rapid	rapid	JJ
cord-305263-fgwf6wy3	28	18	induction	induction	NN
cord-305263-fgwf6wy3	28	19	of	of	IN
cord-305263-fgwf6wy3	28	20	transcription	transcription	NN
cord-305263-fgwf6wy3	28	21	and	and	CC
cord-305263-fgwf6wy3	28	22	translation	translation	NN
cord-305263-fgwf6wy3	28	23	of	of	IN
cord-305263-fgwf6wy3	28	24	ISGs	ISGs	NNPS
cord-305263-fgwf6wy3	28	25	(	(	-LRB-
cord-305263-fgwf6wy3	28	26	Figure	figure	NN
cord-305263-fgwf6wy3	28	27	1	1	CD
cord-305263-fgwf6wy3	28	28	,	,	,
cord-305263-fgwf6wy3	28	29	as	as	IN
cord-305263-fgwf6wy3	28	30	reviewed	review	VBN
cord-305263-fgwf6wy3	28	31	in	in	IN
cord-305263-fgwf6wy3	28	32	[	[	-LRB-
cord-305263-fgwf6wy3	28	33	3	3	CD
cord-305263-fgwf6wy3	28	34	]	]	-RRB-
cord-305263-fgwf6wy3	28	35	)	)	-RRB-
cord-305263-fgwf6wy3	28	36	.	.	.
cord-305263-fgwf6wy3	29	1	Notably	notably	RB
cord-305263-fgwf6wy3	29	2	,	,	,
cord-305263-fgwf6wy3	29	3	IFNARs	IFNARs	NNPS
cord-305263-fgwf6wy3	29	4	are	be	VBP
cord-305263-fgwf6wy3	29	5	ubiquitously	ubiquitously	RB
cord-305263-fgwf6wy3	29	6	expressed	express	VBN
cord-305263-fgwf6wy3	29	7	on	on	IN
cord-305263-fgwf6wy3	29	8	all	all	DT
cord-305263-fgwf6wy3	29	9	cell	cell	NN
cord-305263-fgwf6wy3	29	10	lineages	lineage	NNS
cord-305263-fgwf6wy3	29	11	;	;	:
cord-305263-fgwf6wy3	29	12	probably	probably	RB
cord-305263-fgwf6wy3	29	13	an	an	DT
cord-305263-fgwf6wy3	29	14	evolutionary	evolutionary	JJ
cord-305263-fgwf6wy3	29	15	consequence	consequence	NN
cord-305263-fgwf6wy3	29	16	of	of	IN
cord-305263-fgwf6wy3	29	17	different	different	JJ
cord-305263-fgwf6wy3	29	18	viruses	virus	NNS
cord-305263-fgwf6wy3	29	19	being	be	VBG
cord-305263-fgwf6wy3	29	20	able	able	JJ
cord-305263-fgwf6wy3	29	21	to	to	TO
cord-305263-fgwf6wy3	29	22	target	target	VB
cord-305263-fgwf6wy3	29	23	and	and	CC
cord-305263-fgwf6wy3	29	24	infect	infect	VB
cord-305263-fgwf6wy3	29	25	different	different	JJ
cord-305263-fgwf6wy3	29	26	cell	cell	NN
cord-305263-fgwf6wy3	29	27	types	type	NNS
cord-305263-fgwf6wy3	29	28	.	.	.
cord-305263-fgwf6wy3	30	1	IFNAR	IFNAR	NNP
cord-305263-fgwf6wy3	30	2	expression	expression	NN
cord-305263-fgwf6wy3	30	3	on	on	IN
cord-305263-fgwf6wy3	30	4	any	any	DT
cord-305263-fgwf6wy3	30	5	and	and	CC
cord-305263-fgwf6wy3	30	6	all	all	DT
cord-305263-fgwf6wy3	30	7	cell	cell	NN
cord-305263-fgwf6wy3	30	8	types	type	NNS
cord-305263-fgwf6wy3	30	9	ensures	ensure	VBZ
cord-305263-fgwf6wy3	30	10	that	that	IN
cord-305263-fgwf6wy3	30	11	an	an	DT
cord-305263-fgwf6wy3	30	12	IFN	IFN	NNP
cord-305263-fgwf6wy3	30	13	response	response	NN
cord-305263-fgwf6wy3	30	14	to	to	IN
cord-305263-fgwf6wy3	30	15	a	a	DT
cord-305263-fgwf6wy3	30	16	virus	virus	NN
cord-305263-fgwf6wy3	30	17	may	may	MD
cord-305263-fgwf6wy3	30	18	be	be	VB
cord-305263-fgwf6wy3	30	19	induced	induce	VBN
cord-305263-fgwf6wy3	30	20	upon	upon	IN
cord-305263-fgwf6wy3	30	21	infection	infection	NN
cord-305263-fgwf6wy3	30	22	.	.	.
cord-305263-fgwf6wy3	31	1	As	as	IN
cord-305263-fgwf6wy3	31	2	an	an	DT
cord-305263-fgwf6wy3	31	3	IFN	IFN	NNP
cord-305263-fgwf6wy3	31	4	response	response	NN
cord-305263-fgwf6wy3	31	5	is	be	VBZ
cord-305263-fgwf6wy3	31	6	central	central	JJ
cord-305263-fgwf6wy3	31	7	to	to	IN
cord-305263-fgwf6wy3	31	8	a	a	DT
cord-305263-fgwf6wy3	31	9	robust	robust	JJ
cord-305263-fgwf6wy3	31	10	innate	innate	JJ
cord-305263-fgwf6wy3	31	11	immune	immune	JJ
cord-305263-fgwf6wy3	31	12	response	response	NN
cord-305263-fgwf6wy3	31	13	,	,	,
cord-305263-fgwf6wy3	31	14	viruses	virus	NNS
cord-305263-fgwf6wy3	31	15	have	have	VBP
cord-305263-fgwf6wy3	31	16	evolved	evolve	VBN
cord-305263-fgwf6wy3	31	17	a	a	DT
cord-305263-fgwf6wy3	31	18	variety	variety	NN
cord-305263-fgwf6wy3	31	19	of	of	IN
cord-305263-fgwf6wy3	31	20	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	31	21	to	to	TO
cord-305263-fgwf6wy3	31	22	interfere	interfere	VB
cord-305263-fgwf6wy3	31	23	with	with	IN
cord-305263-fgwf6wy3	31	24	IFN	IFN	NNP
cord-305263-fgwf6wy3	31	25	production	production	NN
cord-305263-fgwf6wy3	31	26	and	and	CC
cord-305263-fgwf6wy3	31	27	signaling	signaling	NN
cord-305263-fgwf6wy3	31	28	,	,	,
cord-305263-fgwf6wy3	31	29	to	to	TO
cord-305263-fgwf6wy3	31	30	disrupt	disrupt	VB
cord-305263-fgwf6wy3	31	31	innate	innate	JJ
cord-305263-fgwf6wy3	31	32	host	host	NN
cord-305263-fgwf6wy3	31	33	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	31	34	factors	factor	NNS
cord-305263-fgwf6wy3	31	35	.	.	.
cord-305263-fgwf6wy3	32	1	Successful	successful	JJ
cord-305263-fgwf6wy3	32	2	viral	viral	JJ
cord-305263-fgwf6wy3	32	3	clearance	clearance	NN
cord-305263-fgwf6wy3	32	4	is	be	VBZ
cord-305263-fgwf6wy3	32	5	determined	determine	VBN
cord-305263-fgwf6wy3	32	6	by	by	IN
cord-305263-fgwf6wy3	32	7	the	the	DT
cord-305263-fgwf6wy3	32	8	balance	balance	NN
cord-305263-fgwf6wy3	32	9	between	between	IN
cord-305263-fgwf6wy3	32	10	virus	virus	NN
cord-305263-fgwf6wy3	32	11	-	-	HYPH
cord-305263-fgwf6wy3	32	12	encoded	encode	VBN
cord-305263-fgwf6wy3	32	13	molecules	molecule	NNS
cord-305263-fgwf6wy3	32	14	that	that	WDT
cord-305263-fgwf6wy3	32	15	antagonize	antagonize	VBP
cord-305263-fgwf6wy3	32	16	the	the	DT
cord-305263-fgwf6wy3	32	17	host	host	NN
cord-305263-fgwf6wy3	32	18	innate	innate	JJ
cord-305263-fgwf6wy3	32	19	immune	immune	JJ
cord-305263-fgwf6wy3	32	20	response	response	NN
cord-305263-fgwf6wy3	32	21	and	and	CC
cord-305263-fgwf6wy3	32	22	the	the	DT
cord-305263-fgwf6wy3	32	23	robustness	robustness	NN
cord-305263-fgwf6wy3	32	24	of	of	IN
cord-305263-fgwf6wy3	32	25	the	the	DT
cord-305263-fgwf6wy3	32	26	host	host	NN
cord-305263-fgwf6wy3	32	27	innate	innate	JJ
cord-305263-fgwf6wy3	32	28	immune	immune	JJ
cord-305263-fgwf6wy3	32	29	response	response	NN
cord-305263-fgwf6wy3	32	30	.	.	.
cord-305263-fgwf6wy3	33	1	Here	here	RB
cord-305263-fgwf6wy3	33	2	,	,	,
cord-305263-fgwf6wy3	33	3	we	-PRON-	PRP
cord-305263-fgwf6wy3	33	4	discuss	discuss	VBP
cord-305263-fgwf6wy3	33	5	how	how	WRB
cord-305263-fgwf6wy3	33	6	IFN	IFN	NNP
cord-305263-fgwf6wy3	33	7	therapy	therapy	NN
cord-305263-fgwf6wy3	33	8	presents	present	VBZ
cord-305263-fgwf6wy3	33	9	as	as	IN
cord-305263-fgwf6wy3	33	10	a	a	DT
cord-305263-fgwf6wy3	33	11	viable	viable	JJ
cord-305263-fgwf6wy3	33	12	treatment	treatment	NN
cord-305263-fgwf6wy3	33	13	option	option	NN
cord-305263-fgwf6wy3	33	14	for	for	IN
cord-305263-fgwf6wy3	33	15	a	a	DT
cord-305263-fgwf6wy3	33	16	range	range	NN
cord-305263-fgwf6wy3	33	17	of	of	IN
cord-305263-fgwf6wy3	33	18	acute	acute	JJ
cord-305263-fgwf6wy3	33	19	virus	virus	NN
cord-305263-fgwf6wy3	33	20	infections	infection	NNS
cord-305263-fgwf6wy3	33	21	that	that	WDT
cord-305263-fgwf6wy3	33	22	target	target	VBP
cord-305263-fgwf6wy3	33	23	a	a	DT
cord-305263-fgwf6wy3	33	24	variety	variety	NN
cord-305263-fgwf6wy3	33	25	of	of	IN
cord-305263-fgwf6wy3	33	26	tissues	tissue	NNS
cord-305263-fgwf6wy3	33	27	,	,	,
cord-305263-fgwf6wy3	33	28	including	include	VBG
cord-305263-fgwf6wy3	33	29	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	33	30	tract	tract	NN
cord-305263-fgwf6wy3	33	31	infections	infection	NNS
cord-305263-fgwf6wy3	33	32	by	by	IN
cord-305263-fgwf6wy3	33	33	severe	severe	JJ
cord-305263-fgwf6wy3	33	34	acute	acute	JJ
cord-305263-fgwf6wy3	33	35	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	33	36	syndrome	syndrome	NN
cord-305263-fgwf6wy3	33	37	coronavirus	coronavirus	NN
cord-305263-fgwf6wy3	33	38	(	(	-LRB-
cord-305263-fgwf6wy3	33	39	SARS	SARS	NNP
cord-305263-fgwf6wy3	33	40	-	-	HYPH
cord-305263-fgwf6wy3	33	41	CoV	CoV	NNP
cord-305263-fgwf6wy3	33	42	)	)	-RRB-
cord-305263-fgwf6wy3	33	43	and	and	CC
cord-305263-fgwf6wy3	33	44	influenza	influenza	VB
cord-305263-fgwf6wy3	33	45	A	a	DT
cord-305263-fgwf6wy3	33	46	viruses	virus	NNS
cord-305263-fgwf6wy3	33	47	,	,	,
cord-305263-fgwf6wy3	33	48	infections	infection	NNS
cord-305263-fgwf6wy3	33	49	of	of	IN
cord-305263-fgwf6wy3	33	50	the	the	DT
cord-305263-fgwf6wy3	33	51	liver	liver	NN
cord-305263-fgwf6wy3	33	52	by	by	IN
cord-305263-fgwf6wy3	33	53	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	33	54	C	C	NNP
cord-305263-fgwf6wy3	33	55	virus	virus	NN
cord-305263-fgwf6wy3	33	56	(	(	-LRB-
cord-305263-fgwf6wy3	33	57	HCV	HCV	NNP
cord-305263-fgwf6wy3	33	58	)	)	-RRB-
cord-305263-fgwf6wy3	33	59	and	and	CC
cord-305263-fgwf6wy3	33	60	hepatitis	hepatitis	NNP
cord-305263-fgwf6wy3	33	61	B	B	NNP
cord-305263-fgwf6wy3	33	62	virus	virus	NN
cord-305263-fgwf6wy3	33	63	(	(	-LRB-
cord-305263-fgwf6wy3	33	64	HBV	HBV	NNP
cord-305263-fgwf6wy3	33	65	)	)	-RRB-
cord-305263-fgwf6wy3	33	66	,	,	,
cord-305263-fgwf6wy3	33	67	and	and	CC
cord-305263-fgwf6wy3	33	68	mucosal	mucosal	JJ
cord-305263-fgwf6wy3	33	69	infections	infection	NNS
cord-305263-fgwf6wy3	33	70	by	by	IN
cord-305263-fgwf6wy3	33	71	herpes	herpes	NN
cord-305263-fgwf6wy3	33	72	simplex	simplex	NNP
cord-305263-fgwf6wy3	33	73	virus	virus	NN
cord-305263-fgwf6wy3	33	74	(	(	-LRB-
cord-305263-fgwf6wy3	33	75	HSV	HSV	NNP
cord-305263-fgwf6wy3	33	76	)	)	-RRB-
cord-305263-fgwf6wy3	33	77	.	.	.
cord-305263-fgwf6wy3	34	1	This	this	DT
cord-305263-fgwf6wy3	34	2	may	may	MD
cord-305263-fgwf6wy3	34	3	be	be	VB
cord-305263-fgwf6wy3	34	4	particularly	particularly	RB
cord-305263-fgwf6wy3	34	5	important	important	JJ
cord-305263-fgwf6wy3	34	6	given	give	VBN
cord-305263-fgwf6wy3	34	7	the	the	DT
cord-305263-fgwf6wy3	34	8	paucity	paucity	NN
cord-305263-fgwf6wy3	34	9	of	of	IN
cord-305263-fgwf6wy3	34	10	broad	broad	JJ
cord-305263-fgwf6wy3	34	11	-	-	HYPH
cord-305263-fgwf6wy3	34	12	spectrum	spectrum	NN
cord-305263-fgwf6wy3	34	13	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	34	14	for	for	IN
cord-305263-fgwf6wy3	34	15	treating	treat	VBG
cord-305263-fgwf6wy3	34	16	newly	newly	RB
cord-305263-fgwf6wy3	34	17	emerging	emerge	VBG
cord-305263-fgwf6wy3	34	18	and	and	CC
cord-305263-fgwf6wy3	34	19	re	re	JJ
cord-305263-fgwf6wy3	34	20	-	-	JJ
cord-305263-fgwf6wy3	34	21	emerging	emerge	VBG
cord-305263-fgwf6wy3	34	22	virus	virus	NN
cord-305263-fgwf6wy3	34	23	infections	infection	NNS
cord-305263-fgwf6wy3	34	24	,	,	,
cord-305263-fgwf6wy3	34	25	which	which	WDT
cord-305263-fgwf6wy3	34	26	present	present	VBP
cord-305263-fgwf6wy3	34	27	a	a	DT
cord-305263-fgwf6wy3	34	28	major	major	JJ
cord-305263-fgwf6wy3	34	29	threat	threat	NN
cord-305263-fgwf6wy3	34	30	to	to	IN
cord-305263-fgwf6wy3	34	31	human	human	JJ
cord-305263-fgwf6wy3	34	32	health	health	NN
cord-305263-fgwf6wy3	34	33	.	.	.
cord-305263-fgwf6wy3	35	1	Yin	Yin	NNP
cord-305263-fgwf6wy3	35	2	:	:	:
cord-305263-fgwf6wy3	35	3	IFN	IFN	NNP
cord-305263-fgwf6wy3	35	4	activates	activate	VBZ
cord-305263-fgwf6wy3	35	5	the	the	DT
cord-305263-fgwf6wy3	35	6	immune	immune	JJ
cord-305263-fgwf6wy3	35	7	system	system	NN
cord-305263-fgwf6wy3	36	1	In	in	IN
cord-305263-fgwf6wy3	36	2	addition	addition	NN
cord-305263-fgwf6wy3	36	3	to	to	IN
cord-305263-fgwf6wy3	36	4	the	the	DT
cord-305263-fgwf6wy3	36	5	induction	induction	NN
cord-305263-fgwf6wy3	36	6	of	of	IN
cord-305263-fgwf6wy3	36	7	ISG	ISG	NNP
cord-305263-fgwf6wy3	36	8	expression	expression	NN
cord-305263-fgwf6wy3	36	9	in	in	IN
cord-305263-fgwf6wy3	36	10	all	all	DT
cord-305263-fgwf6wy3	36	11	cell	cell	NN
cord-305263-fgwf6wy3	36	12	types	type	NNS
cord-305263-fgwf6wy3	36	13	,	,	,
cord-305263-fgwf6wy3	36	14	IFNs	ifn	NNS
cord-305263-fgwf6wy3	36	15	shape	shape	VB
cord-305263-fgwf6wy3	36	16	the	the	DT
cord-305263-fgwf6wy3	36	17	landscape	landscape	NN
cord-305263-fgwf6wy3	36	18	of	of	IN
cord-305263-fgwf6wy3	36	19	the	the	DT
cord-305263-fgwf6wy3	36	20	immune	immune	JJ
cord-305263-fgwf6wy3	36	21	system	system	NN
cord-305263-fgwf6wy3	36	22	in	in	IN
cord-305263-fgwf6wy3	36	23	response	response	NN
cord-305263-fgwf6wy3	36	24	to	to	IN
cord-305263-fgwf6wy3	36	25	virus	virus	NN
cord-305263-fgwf6wy3	36	26	infection	infection	NN
cord-305263-fgwf6wy3	36	27	by	by	IN
cord-305263-fgwf6wy3	36	28	promoting	promote	VBG
cord-305263-fgwf6wy3	36	29	neutrophil	neutrophil	NN
cord-305263-fgwf6wy3	36	30	survival	survival	NN
cord-305263-fgwf6wy3	36	31	[	[	-LRB-
cord-305263-fgwf6wy3	36	32	3	3	CD
cord-305263-fgwf6wy3	36	33	,	,	,
cord-305263-fgwf6wy3	36	34	5	5	CD
cord-305263-fgwf6wy3	36	35	]	]	-RRB-
cord-305263-fgwf6wy3	36	36	and	and	CC
cord-305263-fgwf6wy3	36	37	the	the	DT
cord-305263-fgwf6wy3	36	38	activation	activation	NN
cord-305263-fgwf6wy3	36	39	of	of	IN
cord-305263-fgwf6wy3	36	40	macrophages	macrophage	NNS
cord-305263-fgwf6wy3	36	41	[	[	-LRB-
cord-305263-fgwf6wy3	36	42	6	6	CD
cord-305263-fgwf6wy3	36	43	]	]	-RRB-
cord-305263-fgwf6wy3	36	44	,	,	,
cord-305263-fgwf6wy3	36	45	natural	natural	JJ
cord-305263-fgwf6wy3	36	46	killer	killer	NN
cord-305263-fgwf6wy3	36	47	cells	cell	NNS
cord-305263-fgwf6wy3	36	48	[	[	-LRB-
cord-305263-fgwf6wy3	36	49	7	7	CD
cord-305263-fgwf6wy3	36	50	]	]	-RRB-
cord-305263-fgwf6wy3	36	51	,	,	,
cord-305263-fgwf6wy3	36	52	DCs	DCs	NNP
cord-305263-fgwf6wy3	36	53	[	[	-LRB-
cord-305263-fgwf6wy3	36	54	1	1	CD
cord-305263-fgwf6wy3	36	55	,	,	,
cord-305263-fgwf6wy3	36	56	8	8	CD
cord-305263-fgwf6wy3	36	57	]	]	-RRB-
cord-305263-fgwf6wy3	36	58	,	,	,
cord-305263-fgwf6wy3	36	59	B	b	NN
cord-305263-fgwf6wy3	36	60	cells	cell	NNS
cord-305263-fgwf6wy3	36	61	[	[	-LRB-
cord-305263-fgwf6wy3	36	62	9	9	CD
cord-305263-fgwf6wy3	36	63	]	]	-RRB-
cord-305263-fgwf6wy3	36	64	and	and	CC
cord-305263-fgwf6wy3	36	65	CD8	CD8	NNP
cord-305263-fgwf6wy3	36	66	+	+	CC
cord-305263-fgwf6wy3	36	67	T	T	NNP
cord-305263-fgwf6wy3	36	68	cells	cell	NNS
cord-305263-fgwf6wy3	36	69	[	[	-LRB-
cord-305263-fgwf6wy3	36	70	1	1	CD
cord-305263-fgwf6wy3	36	71	]	]	-RRB-
cord-305263-fgwf6wy3	36	72	,	,	,
cord-305263-fgwf6wy3	36	73	and	and	CC
cord-305263-fgwf6wy3	36	74	T	T	NNP
cord-305263-fgwf6wy3	36	75	helper	helper	NN
cord-305263-fgwf6wy3	36	76	(	(	-LRB-
cord-305263-fgwf6wy3	36	77	Th)1	th)1	NN
cord-305263-fgwf6wy3	36	78	polarization	polarization	NN
cord-305263-fgwf6wy3	36	79	of	of	IN
cord-305263-fgwf6wy3	36	80	effector	effector	NN
cord-305263-fgwf6wy3	36	81	CD4	CD4	NNP
cord-305263-fgwf6wy3	36	82	+	+	CC
cord-305263-fgwf6wy3	36	83	T	t	NN
cord-305263-fgwf6wy3	36	84	cells	cell	NNS
cord-305263-fgwf6wy3	36	85	[	[	-LRB-
cord-305263-fgwf6wy3	36	86	8	8	CD
cord-305263-fgwf6wy3	36	87	]	]	-RRB-
cord-305263-fgwf6wy3	37	1	(	(	-LRB-
cord-305263-fgwf6wy3	37	2	Figure	figure	NN
cord-305263-fgwf6wy3	37	3	2	2	CD
cord-305263-fgwf6wy3	37	4	)	)	-RRB-
cord-305263-fgwf6wy3	37	5	.	.	.
cord-305263-fgwf6wy3	38	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	38	2	therapy	therapy	NN
cord-305263-fgwf6wy3	38	3	therefore	therefore	RB
cord-305263-fgwf6wy3	38	4	has	have	VBZ
cord-305263-fgwf6wy3	38	5	the	the	DT
cord-305263-fgwf6wy3	38	6	advantage	advantage	NN
cord-305263-fgwf6wy3	38	7	over	over	IN
cord-305263-fgwf6wy3	38	8	DAA	DAA	NNP
cord-305263-fgwf6wy3	38	9	treatments	treatment	NNS
cord-305263-fgwf6wy3	38	10	in	in	IN
cord-305263-fgwf6wy3	38	11	that	that	DT
cord-305263-fgwf6wy3	38	12	,	,	,
cord-305263-fgwf6wy3	38	13	in	in	IN
cord-305263-fgwf6wy3	38	14	addition	addition	NN
cord-305263-fgwf6wy3	38	15	to	to	IN
cord-305263-fgwf6wy3	38	16	stimulating	stimulate	VBG
cord-305263-fgwf6wy3	38	17	genes	gene	NNS
cord-305263-fgwf6wy3	38	18	that	that	WDT
cord-305263-fgwf6wy3	38	19	block	block	VBP
cord-305263-fgwf6wy3	38	20	viral	viral	JJ
cord-305263-fgwf6wy3	38	21	replication	replication	NN
cord-305263-fgwf6wy3	38	22	in	in	IN
cord-305263-fgwf6wy3	38	23	infected	infected	JJ
cord-305263-fgwf6wy3	38	24	cells	cell	NNS
cord-305263-fgwf6wy3	38	25	,	,	,
cord-305263-fgwf6wy3	38	26	IFNs	ifn	NNS
cord-305263-fgwf6wy3	38	27	activate	activate	VBP
cord-305263-fgwf6wy3	38	28	other	other	JJ
cord-305263-fgwf6wy3	38	29	innate	innate	JJ
cord-305263-fgwf6wy3	38	30	and	and	CC
cord-305263-fgwf6wy3	38	31	adaptive	adaptive	JJ
cord-305263-fgwf6wy3	38	32	immune	immune	JJ
cord-305263-fgwf6wy3	38	33	responses	response	NNS
cord-305263-fgwf6wy3	38	34	to	to	TO
cord-305263-fgwf6wy3	38	35	combat	combat	VB
cord-305263-fgwf6wy3	38	36	the	the	DT
cord-305263-fgwf6wy3	38	37	virus	virus	NN
cord-305263-fgwf6wy3	38	38	.	.	.
cord-305263-fgwf6wy3	39	1	Polymorphisms	polymorphism	NNS
cord-305263-fgwf6wy3	39	2	in	in	IN
cord-305263-fgwf6wy3	39	3	genes	gene	NNS
cord-305263-fgwf6wy3	39	4	encoding	encoding	NN
cord-305263-fgwf6wy3	39	5	factors	factor	NNS
cord-305263-fgwf6wy3	39	6	involved	involve	VBN
cord-305263-fgwf6wy3	39	7	in	in	IN
cord-305263-fgwf6wy3	39	8	different	different	JJ
cord-305263-fgwf6wy3	39	9	stages	stage	NNS
cord-305263-fgwf6wy3	39	10	of	of	IN
cord-305263-fgwf6wy3	39	11	the	the	DT
cord-305263-fgwf6wy3	39	12	IFN	IFN	NNP
cord-305263-fgwf6wy3	39	13	response	response	NN
cord-305263-fgwf6wy3	39	14	can	can	MD
cord-305263-fgwf6wy3	39	15	lead	lead	VB
cord-305263-fgwf6wy3	39	16	to	to	IN
cord-305263-fgwf6wy3	39	17	marked	marked	JJ
cord-305263-fgwf6wy3	39	18	differences	difference	NNS
cord-305263-fgwf6wy3	39	19	in	in	IN
cord-305263-fgwf6wy3	39	20	susceptibility	susceptibility	NN
cord-305263-fgwf6wy3	39	21	to	to	IN
cord-305263-fgwf6wy3	39	22	virus	virus	NN
cord-305263-fgwf6wy3	39	23	infection	infection	NN
cord-305263-fgwf6wy3	39	24	and	and	CC
cord-305263-fgwf6wy3	39	25	severity	severity	NN
cord-305263-fgwf6wy3	39	26	of	of	IN
cord-305263-fgwf6wy3	39	27	disease	disease	NN
cord-305263-fgwf6wy3	39	28	,	,	,
cord-305263-fgwf6wy3	39	29	and	and	CC
cord-305263-fgwf6wy3	39	30	can	can	MD
cord-305263-fgwf6wy3	39	31	also	also	RB
cord-305263-fgwf6wy3	39	32	serve	serve	VB
cord-305263-fgwf6wy3	39	33	as	as	IN
cord-305263-fgwf6wy3	39	34	predictive	predictive	JJ
cord-305263-fgwf6wy3	39	35	markers	marker	NNS
cord-305263-fgwf6wy3	39	36	for	for	IN
cord-305263-fgwf6wy3	39	37	the	the	DT
cord-305263-fgwf6wy3	39	38	outcome	outcome	NN
cord-305263-fgwf6wy3	39	39	of	of	IN
cord-305263-fgwf6wy3	39	40	IFN	IFN	NNP
cord-305263-fgwf6wy3	39	41	treatment	treatment	NN
cord-305263-fgwf6wy3	39	42	.	.	.
cord-305263-fgwf6wy3	40	1	For	for	IN
cord-305263-fgwf6wy3	40	2	example	example	NN
cord-305263-fgwf6wy3	40	3	,	,	,
cord-305263-fgwf6wy3	40	4	polymorphisms	polymorphism	NNS
cord-305263-fgwf6wy3	40	5	in	in	IN
cord-305263-fgwf6wy3	40	6	host	host	NN
cord-305263-fgwf6wy3	40	7	genes	gene	NNS
cord-305263-fgwf6wy3	40	8	encoding	encode	VBG
cord-305263-fgwf6wy3	40	9	proteins	protein	NNS
cord-305263-fgwf6wy3	40	10	associated	associate	VBN
cord-305263-fgwf6wy3	40	11	with	with	IN
cord-305263-fgwf6wy3	40	12	regulation	regulation	NN
cord-305263-fgwf6wy3	40	13	of	of	IN
cord-305263-fgwf6wy3	40	14	an	an	DT
cord-305263-fgwf6wy3	40	15	IFN	IFN	NNP
cord-305263-fgwf6wy3	40	16	response	response	NN
cord-305263-fgwf6wy3	40	17	such	such	JJ
cord-305263-fgwf6wy3	40	18	as	as	IN
cord-305263-fgwf6wy3	40	19	interferon	interferon	NN
cord-305263-fgwf6wy3	40	20	receptor	receptor	NN
cord-305263-fgwf6wy3	40	21	a	a	DT
cord-305263-fgwf6wy3	40	22	-	-	HYPH
cord-305263-fgwf6wy3	40	23	chain	chain	NN
cord-305263-fgwf6wy3	40	24	(	(	-LRB-
cord-305263-fgwf6wy3	40	25	IFNAR1	ifnar1	NN
cord-305263-fgwf6wy3	40	26	)	)	-RRB-
cord-305263-fgwf6wy3	40	27	[	[	-LRB-
cord-305263-fgwf6wy3	40	28	10	10	CD
cord-305263-fgwf6wy3	40	29	]	]	-RRB-
cord-305263-fgwf6wy3	40	30	,	,	,
cord-305263-fgwf6wy3	40	31	the	the	DT
cord-305263-fgwf6wy3	40	32	IFN	IFN	NNP
cord-305263-fgwf6wy3	40	33	-	-	HYPH
cord-305263-fgwf6wy3	40	34	inducible	inducible	JJ
cord-305263-fgwf6wy3	40	35	myxovirus	myxovirus	JJ
cord-305263-fgwf6wy3	40	36	resistance	resistance	NN
cord-305263-fgwf6wy3	40	37	GTPase	GTPase	NNP
cord-305263-fgwf6wy3	40	38	protein	protein	NN
cord-305263-fgwf6wy3	40	39	,	,	,
cord-305263-fgwf6wy3	40	40	Mx	Mx	NNP
cord-305263-fgwf6wy3	40	41	[	[	-LRB-
cord-305263-fgwf6wy3	40	42	11	11	CD
cord-305263-fgwf6wy3	40	43	]	]	-RRB-
cord-305263-fgwf6wy3	40	44	,	,	,
cord-305263-fgwf6wy3	40	45	the	the	DT
cord-305263-fgwf6wy3	40	46	IFN	IFN	NNP
cord-305263-fgwf6wy3	40	47	-	-	HYPH
cord-305263-fgwf6wy3	40	48	inducible	inducible	JJ
cord-305263-fgwf6wy3	40	49	2	2	CD
cord-305263-fgwf6wy3	40	50	0	0	CD
cord-305263-fgwf6wy3	40	51	,	,	,
cord-305263-fgwf6wy3	41	1	5	5	LS
cord-305263-fgwf6wy3	41	2	0	0	CD
cord-305263-fgwf6wy3	41	3	-oligoadenylate	-oligoadenylate	HYPH
cord-305263-fgwf6wy3	41	4	synthetase	synthetase	NN
cord-305263-fgwf6wy3	41	5	(	(	-LRB-
cord-305263-fgwf6wy3	41	6	OAS	OAS	NNP
cord-305263-fgwf6wy3	41	7	)	)	-RRB-
cord-305263-fgwf6wy3	41	8	[	[	-LRB-
cord-305263-fgwf6wy3	41	9	12	12	CD
cord-305263-fgwf6wy3	41	10	]	]	-RRB-
cord-305263-fgwf6wy3	41	11	and	and	CC
cord-305263-fgwf6wy3	41	12	the	the	DT
cord-305263-fgwf6wy3	41	13	suppressor	suppressor	NN
cord-305263-fgwf6wy3	41	14	of	of	IN
cord-305263-fgwf6wy3	41	15	cytokine	cytokine	NN
cord-305263-fgwf6wy3	41	16	signaling	signaling	NN
cord-305263-fgwf6wy3	41	17	(	(	-LRB-
cord-305263-fgwf6wy3	41	18	SOCS	SOCS	NNP
cord-305263-fgwf6wy3	41	19	)	)	-RRB-
cord-305263-fgwf6wy3	41	20	3	3	CD
cord-305263-fgwf6wy3	41	21	associated	associate	VBN
cord-305263-fgwf6wy3	41	22	with	with	IN
cord-305263-fgwf6wy3	41	23	regulation	regulation	NN
cord-305263-fgwf6wy3	41	24	of	of	IN
cord-305263-fgwf6wy3	41	25	an	an	DT
cord-305263-fgwf6wy3	41	26	IFN	IFN	NNP
cord-305263-fgwf6wy3	41	27	response	response	NN
cord-305263-fgwf6wy3	41	28	[	[	-LRB-
cord-305263-fgwf6wy3	41	29	13	13	CD
cord-305263-fgwf6wy3	41	30	]	]	-RRB-
cord-305263-fgwf6wy3	41	31	,	,	,
cord-305263-fgwf6wy3	41	32	are	be	VBP
cord-305263-fgwf6wy3	41	33	predictive	predictive	JJ
cord-305263-fgwf6wy3	41	34	markers	marker	NNS
cord-305263-fgwf6wy3	41	35	linked	link	VBN
cord-305263-fgwf6wy3	41	36	with	with	IN
cord-305263-fgwf6wy3	41	37	the	the	DT
cord-305263-fgwf6wy3	41	38	rate	rate	NN
cord-305263-fgwf6wy3	41	39	of	of	IN
cord-305263-fgwf6wy3	41	40	sustained	sustained	JJ
cord-305263-fgwf6wy3	41	41	virological	virological	JJ
cord-305263-fgwf6wy3	41	42	response	response	NN
cord-305263-fgwf6wy3	41	43	(	(	-LRB-
cord-305263-fgwf6wy3	41	44	SVR	SVR	NNP
cord-305263-fgwf6wy3	41	45	)	)	-RRB-
cord-305263-fgwf6wy3	41	46	to	to	IN
cord-305263-fgwf6wy3	41	47	HCV	HCV	NNP
cord-305263-fgwf6wy3	41	48	infection	infection	NN
cord-305263-fgwf6wy3	41	49	following	follow	VBG
cord-305263-fgwf6wy3	41	50	IFN	IFN	NNP
cord-305263-fgwf6wy3	41	51	-	-	:
cord-305263-fgwf6wy3	41	52	a	a	DT
cord-305263-fgwf6wy3	41	53	treatment	treatment	NN
cord-305263-fgwf6wy3	41	54	.	.	.
cord-305263-fgwf6wy3	42	1	This	this	DT
cord-305263-fgwf6wy3	42	2	highlights	highlight	VBZ
cord-305263-fgwf6wy3	42	3	the	the	DT
cord-305263-fgwf6wy3	42	4	importance	importance	NN
cord-305263-fgwf6wy3	42	5	of	of	IN
cord-305263-fgwf6wy3	42	6	an	an	DT
cord-305263-fgwf6wy3	42	7	intact	intact	JJ
cord-305263-fgwf6wy3	42	8	IFN	IFN	NNP
cord-305263-fgwf6wy3	42	9	response	response	NN
cord-305263-fgwf6wy3	42	10	during	during	IN
cord-305263-fgwf6wy3	42	11	viral	viral	JJ
cord-305263-fgwf6wy3	42	12	infection	infection	NN
cord-305263-fgwf6wy3	42	13	and	and	CC
cord-305263-fgwf6wy3	42	14	indicates	indicate	VBZ
cord-305263-fgwf6wy3	42	15	that	that	IN
cord-305263-fgwf6wy3	42	16	genetic	genetic	JJ
cord-305263-fgwf6wy3	42	17	variations	variation	NNS
cord-305263-fgwf6wy3	42	18	among	among	IN
cord-305263-fgwf6wy3	42	19	patients	patient	NNS
cord-305263-fgwf6wy3	42	20	can	can	MD
cord-305263-fgwf6wy3	42	21	present	present	VB
cord-305263-fgwf6wy3	42	22	as	as	IN
cord-305263-fgwf6wy3	42	23	a	a	DT
cord-305263-fgwf6wy3	42	24	challenge	challenge	NN
cord-305263-fgwf6wy3	42	25	for	for	IN
cord-305263-fgwf6wy3	42	26	optimizing	optimize	VBG
cord-305263-fgwf6wy3	42	27	IFN	IFN	NNP
cord-305263-fgwf6wy3	42	28	therapy	therapy	NN
cord-305263-fgwf6wy3	42	29	.	.	.
cord-305263-fgwf6wy3	43	1	Yang	Yang	NNP
cord-305263-fgwf6wy3	43	2	:	:	:
cord-305263-fgwf6wy3	43	3	virulence	virulence	NN
cord-305263-fgwf6wy3	43	4	factors	factor	NNS
cord-305263-fgwf6wy3	43	5	antagonize	antagonize	VBP
cord-305263-fgwf6wy3	43	6	the	the	DT
cord-305263-fgwf6wy3	43	7	IFN	IFN	NNP
cord-305263-fgwf6wy3	43	8	response	response	NN
cord-305263-fgwf6wy3	44	1	It	-PRON-	PRP
cord-305263-fgwf6wy3	44	2	is	be	VBZ
cord-305263-fgwf6wy3	44	3	not	not	RB
cord-305263-fgwf6wy3	44	4	surprising	surprising	JJ
cord-305263-fgwf6wy3	44	5	that	that	IN
cord-305263-fgwf6wy3	44	6	many	many	JJ
cord-305263-fgwf6wy3	44	7	pathogenic	pathogenic	JJ
cord-305263-fgwf6wy3	44	8	viruses	virus	NNS
cord-305263-fgwf6wy3	44	9	,	,	,
cord-305263-fgwf6wy3	44	10	including	include	VBG
cord-305263-fgwf6wy3	44	11	SARS	SARS	NNP
cord-305263-fgwf6wy3	44	12	-	-	HYPH
cord-305263-fgwf6wy3	44	13	CoV	CoV	NNP
cord-305263-fgwf6wy3	44	14	,	,	,
cord-305263-fgwf6wy3	44	15	influenza	influenza	NN
cord-305263-fgwf6wy3	44	16	A	a	DT
cord-305263-fgwf6wy3	44	17	viruses	virus	NNS
cord-305263-fgwf6wy3	44	18	,	,	,
cord-305263-fgwf6wy3	44	19	HCV	HCV	NNP
cord-305263-fgwf6wy3	44	20	and	and	CC
cord-305263-fgwf6wy3	44	21	HSV	HSV	NNP
cord-305263-fgwf6wy3	44	22	,	,	,
cord-305263-fgwf6wy3	44	23	have	have	VBP
cord-305263-fgwf6wy3	44	24	developed	develop	VBN
cord-305263-fgwf6wy3	44	25	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	44	26	to	to	TO
cord-305263-fgwf6wy3	44	27	disrupt	disrupt	VB
cord-305263-fgwf6wy3	44	28	and	and	CC
cord-305263-fgwf6wy3	44	29	limit	limit	VB
cord-305263-fgwf6wy3	44	30	the	the	DT
cord-305263-fgwf6wy3	44	31	IFN	IFN	NNP
cord-305263-fgwf6wy3	44	32	-	-	HYPH
cord-305263-fgwf6wy3	44	33	a	a	NNP
cord-305263-fgwf6wy3	44	34	/	/	SYM
cord-305263-fgwf6wy3	44	35	b	b	NN
cord-305263-fgwf6wy3	44	36	response	response	NN
cord-305263-fgwf6wy3	44	37	(	(	-LRB-
cord-305263-fgwf6wy3	44	38	Table	table	NN
cord-305263-fgwf6wy3	44	39	1	1	CD
cord-305263-fgwf6wy3	44	40	)	)	-RRB-
cord-305263-fgwf6wy3	44	41	.	.	.
cord-305263-fgwf6wy3	45	1	Many	many	JJ
cord-305263-fgwf6wy3	45	2	viruses	virus	NNS
cord-305263-fgwf6wy3	45	3	are	be	VBP
cord-305263-fgwf6wy3	45	4	able	able	JJ
cord-305263-fgwf6wy3	45	5	to	to	TO
cord-305263-fgwf6wy3	45	6	evade	evade	VB
cord-305263-fgwf6wy3	45	7	the	the	DT
cord-305263-fgwf6wy3	45	8	innate	innate	JJ
cord-305263-fgwf6wy3	45	9	immune	immune	JJ
cord-305263-fgwf6wy3	45	10	system	system	NN
cord-305263-fgwf6wy3	45	11	by	by	IN
cord-305263-fgwf6wy3	45	12	directly	directly	RB
cord-305263-fgwf6wy3	45	13	targeting	target	VBG
cord-305263-fgwf6wy3	45	14	pathways	pathway	NNS
cord-305263-fgwf6wy3	45	15	required	require	VBN
cord-305263-fgwf6wy3	45	16	for	for	IN
cord-305263-fgwf6wy3	45	17	the	the	DT
cord-305263-fgwf6wy3	45	18	induction	induction	NN
cord-305263-fgwf6wy3	45	19	of	of	IN
cord-305263-fgwf6wy3	45	20	IFN	IFN	NNP
cord-305263-fgwf6wy3	45	21	-	-	HYPH
cord-305263-fgwf6wy3	45	22	a	a	NNP
cord-305263-fgwf6wy3	45	23	/	/	SYM
cord-305263-fgwf6wy3	45	24	b	b	NN
cord-305263-fgwf6wy3	45	25	production	production	NN
cord-305263-fgwf6wy3	45	26	[	[	-LRB-
cord-305263-fgwf6wy3	45	27	14	14	CD
cord-305263-fgwf6wy3	45	28	]	]	-RRB-
cord-305263-fgwf6wy3	45	29	[	[	-LRB-
cord-305263-fgwf6wy3	45	30	15	15	CD
cord-305263-fgwf6wy3	45	31	]	]	-RRB-
cord-305263-fgwf6wy3	45	32	[	[	-LRB-
cord-305263-fgwf6wy3	45	33	16	16	CD
cord-305263-fgwf6wy3	45	34	]	]	-RRB-
cord-305263-fgwf6wy3	45	35	[	[	-LRB-
cord-305263-fgwf6wy3	45	36	17	17	CD
cord-305263-fgwf6wy3	45	37	]	]	-RRB-
cord-305263-fgwf6wy3	45	38	[	[	-LRB-
cord-305263-fgwf6wy3	45	39	18	18	CD
cord-305263-fgwf6wy3	45	40	]	]	-RRB-
cord-305263-fgwf6wy3	45	41	.	.	.
cord-305263-fgwf6wy3	46	1	These	these	DT
cord-305263-fgwf6wy3	46	2	viruses	virus	NNS
cord-305263-fgwf6wy3	46	3	are	be	VBP
cord-305263-fgwf6wy3	46	4	also	also	RB
cord-305263-fgwf6wy3	46	5	able	able	JJ
cord-305263-fgwf6wy3	46	6	to	to	TO
cord-305263-fgwf6wy3	46	7	inhibit	inhibit	VB
cord-305263-fgwf6wy3	46	8	an	an	DT
cord-305263-fgwf6wy3	46	9	IFN	IFN	NNP
cord-305263-fgwf6wy3	46	10	response	response	NN
cord-305263-fgwf6wy3	46	11	,	,	,
cord-305263-fgwf6wy3	46	12	by	by	IN
cord-305263-fgwf6wy3	46	13	interfering	interfere	VBG
cord-305263-fgwf6wy3	46	14	with	with	IN
cord-305263-fgwf6wy3	46	15	effectors	effector	NNS
cord-305263-fgwf6wy3	46	16	in	in	IN
cord-305263-fgwf6wy3	46	17	IFN	IFN	NNP
cord-305263-fgwf6wy3	46	18	-	-	HYPH
cord-305263-fgwf6wy3	46	19	inducible	inducible	JJ
cord-305263-fgwf6wy3	46	20	signaling	signaling	NN
cord-305263-fgwf6wy3	46	21	cascades	cascade	NNS
cord-305263-fgwf6wy3	46	22	[	[	-LRB-
cord-305263-fgwf6wy3	46	23	19	19	CD
cord-305263-fgwf6wy3	46	24	]	]	-RRB-
cord-305263-fgwf6wy3	47	1	[	[	-LRB-
cord-305263-fgwf6wy3	47	2	20	20	CD
cord-305263-fgwf6wy3	47	3	]	]	-RRB-
cord-305263-fgwf6wy3	47	4	[	[	-LRB-
cord-305263-fgwf6wy3	47	5	21	21	CD
cord-305263-fgwf6wy3	47	6	]	]	-RRB-
cord-305263-fgwf6wy3	47	7	.	.	.
cord-305263-fgwf6wy3	48	1	Understanding	understand	VBG
cord-305263-fgwf6wy3	48	2	the	the	DT
cord-305263-fgwf6wy3	48	3	basis	basis	NN
cord-305263-fgwf6wy3	48	4	of	of	IN
cord-305263-fgwf6wy3	48	5	these	these	DT
cord-305263-fgwf6wy3	48	6	antagonistic	antagonistic	JJ
cord-305263-fgwf6wy3	48	7	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	48	8	is	be	VBZ
cord-305263-fgwf6wy3	48	9	essential	essential	JJ
cord-305263-fgwf6wy3	48	10	for	for	IN
cord-305263-fgwf6wy3	48	11	optimizing	optimize	VBG
cord-305263-fgwf6wy3	48	12	the	the	DT
cord-305263-fgwf6wy3	48	13	timing	timing	NN
cord-305263-fgwf6wy3	48	14	and	and	CC
cord-305263-fgwf6wy3	48	15	dosage	dosage	NN
cord-305263-fgwf6wy3	48	16	of	of	IN
cord-305263-fgwf6wy3	48	17	IFN	IFN	NNP
cord-305263-fgwf6wy3	48	18	treatments	treatment	NNS
cord-305263-fgwf6wy3	48	19	as	as	IN
cord-305263-fgwf6wy3	48	20	a	a	DT
cord-305263-fgwf6wy3	48	21	viable	viable	JJ
cord-305263-fgwf6wy3	48	22	therapy	therapy	NN
cord-305263-fgwf6wy3	48	23	for	for	IN
cord-305263-fgwf6wy3	48	24	acute	acute	JJ
cord-305263-fgwf6wy3	48	25	virus	virus	NN
cord-305263-fgwf6wy3	48	26	infections	infection	NNS
cord-305263-fgwf6wy3	48	27	.	.	.
cord-305263-fgwf6wy3	49	1	Box	box	NN
cord-305263-fgwf6wy3	49	2	1	1	CD
cord-305263-fgwf6wy3	49	3	.	.	.
cord-305263-fgwf6wy3	50	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	50	2	-	-	HYPH
cord-305263-fgwf6wy3	50	3	a	a	NN
cord-305263-fgwf6wy3	50	4	/	/	SYM
cord-305263-fgwf6wy3	50	5	b	b	NN
cord-305263-fgwf6wy3	50	6	induction	induction	NN
cord-305263-fgwf6wy3	50	7	by	by	IN
cord-305263-fgwf6wy3	50	8	viral	viral	JJ
cord-305263-fgwf6wy3	50	9	pathogen	pathogen	NN
cord-305263-fgwf6wy3	50	10	-	-	HYPH
cord-305263-fgwf6wy3	50	11	associated	associate	VBN
cord-305263-fgwf6wy3	50	12	molecular	molecular	JJ
cord-305263-fgwf6wy3	50	13	patterns	pattern	NNS
cord-305263-fgwf6wy3	50	14	(	(	-LRB-
cord-305263-fgwf6wy3	50	15	PAMPs	PAMPs	NNP
cord-305263-fgwf6wy3	50	16	)	)	-RRB-
cord-305263-fgwf6wy3	50	17	PRRs	prr	NNS
cord-305263-fgwf6wy3	50	18	,	,	,
cord-305263-fgwf6wy3	50	19	including	include	VBG
cord-305263-fgwf6wy3	50	20	membrane	membrane	NN
cord-305263-fgwf6wy3	50	21	-	-	HYPH
cord-305263-fgwf6wy3	50	22	associated	associate	VBN
cord-305263-fgwf6wy3	50	23	Toll	Toll	NNP
cord-305263-fgwf6wy3	50	24	-	-	HYPH
cord-305263-fgwf6wy3	50	25	like	like	JJ
cord-305263-fgwf6wy3	50	26	receptors	receptor	NNS
cord-305263-fgwf6wy3	50	27	(	(	-LRB-
cord-305263-fgwf6wy3	50	28	TLRs	TLRs	NNP
cord-305263-fgwf6wy3	50	29	)	)	-RRB-
cord-305263-fgwf6wy3	50	30	,	,	,
cord-305263-fgwf6wy3	50	31	and	and	CC
cord-305263-fgwf6wy3	50	32	cytosolic	cytosolic	JJ
cord-305263-fgwf6wy3	50	33	RNA	RNA	NNP
cord-305263-fgwf6wy3	50	34	and	and	CC
cord-305263-fgwf6wy3	50	35	DNA	dna	NN
cord-305263-fgwf6wy3	50	36	sensors	sensor	NNS
cord-305263-fgwf6wy3	50	37	such	such	JJ
cord-305263-fgwf6wy3	50	38	as	as	IN
cord-305263-fgwf6wy3	50	39	RIG	rig	NN
cord-305263-fgwf6wy3	50	40	-	-	:
cord-305263-fgwf6wy3	50	41	I	I	NNP
cord-305263-fgwf6wy3	50	42	,	,	,
cord-305263-fgwf6wy3	50	43	are	be	VBP
cord-305263-fgwf6wy3	50	44	able	able	JJ
cord-305263-fgwf6wy3	50	45	to	to	TO
cord-305263-fgwf6wy3	50	46	detect	detect	VB
cord-305263-fgwf6wy3	50	47	both	both	DT
cord-305263-fgwf6wy3	50	48	extracellular	extracellular	JJ
cord-305263-fgwf6wy3	50	49	,	,	,
cord-305263-fgwf6wy3	50	50	endosomal	endosomal	JJ
cord-305263-fgwf6wy3	50	51	or	or	CC
cord-305263-fgwf6wy3	50	52	cytosolic	cytosolic	JJ
cord-305263-fgwf6wy3	50	53	viral	viral	JJ
cord-305263-fgwf6wy3	50	54	PAMPs	pamp	NNS
cord-305263-fgwf6wy3	50	55	:	:	:
cord-305263-fgwf6wy3	50	56	viral	viral	JJ
cord-305263-fgwf6wy3	50	57	genomic	genomic	JJ
cord-305263-fgwf6wy3	50	58	material	material	NN
cord-305263-fgwf6wy3	50	59	.	.	.
cord-305263-fgwf6wy3	51	1	The	the	DT
cord-305263-fgwf6wy3	51	2	primary	primary	JJ
cord-305263-fgwf6wy3	51	3	outcome	outcome	NN
cord-305263-fgwf6wy3	51	4	of	of	IN
cord-305263-fgwf6wy3	51	5	this	this	DT
cord-305263-fgwf6wy3	51	6	nonspecific	nonspecific	JJ
cord-305263-fgwf6wy3	51	7	surveillance	surveillance	NN
cord-305263-fgwf6wy3	51	8	system	system	NN
cord-305263-fgwf6wy3	51	9	that	that	WDT
cord-305263-fgwf6wy3	51	10	detects	detect	VBZ
cord-305263-fgwf6wy3	51	11	any	any	DT
cord-305263-fgwf6wy3	51	12	and	and	CC
cord-305263-fgwf6wy3	51	13	all	all	DT
cord-305263-fgwf6wy3	51	14	viruses	virus	NNS
cord-305263-fgwf6wy3	51	15	,	,	,
cord-305263-fgwf6wy3	51	16	regardless	regardless	RB
cord-305263-fgwf6wy3	51	17	of	of	IN
cord-305263-fgwf6wy3	51	18	the	the	DT
cord-305263-fgwf6wy3	51	19	target	target	NN
cord-305263-fgwf6wy3	51	20	cell	cell	NN
cord-305263-fgwf6wy3	51	21	or	or	CC
cord-305263-fgwf6wy3	51	22	tissue	tissue	NN
cord-305263-fgwf6wy3	51	23	tropism	tropism	NN
cord-305263-fgwf6wy3	51	24	of	of	IN
cord-305263-fgwf6wy3	51	25	the	the	DT
cord-305263-fgwf6wy3	51	26	virus	virus	NN
cord-305263-fgwf6wy3	51	27	,	,	,
cord-305263-fgwf6wy3	51	28	and	and	CC
cord-305263-fgwf6wy3	51	29	independent	independent	JJ
cord-305263-fgwf6wy3	51	30	of	of	IN
cord-305263-fgwf6wy3	51	31	where	where	WRB
cord-305263-fgwf6wy3	51	32	the	the	DT
cord-305263-fgwf6wy3	51	33	virus	virus	NN
cord-305263-fgwf6wy3	51	34	is	be	VBZ
cord-305263-fgwf6wy3	51	35	located	locate	VBN
cord-305263-fgwf6wy3	51	36	,	,	,
cord-305263-fgwf6wy3	51	37	is	be	VBZ
cord-305263-fgwf6wy3	51	38	the	the	DT
cord-305263-fgwf6wy3	51	39	transcriptional	transcriptional	JJ
cord-305263-fgwf6wy3	51	40	activation	activation	NN
cord-305263-fgwf6wy3	51	41	of	of	IN
cord-305263-fgwf6wy3	51	42	IFN	IFN	NNP
cord-305263-fgwf6wy3	51	43	-	-	HYPH
cord-305263-fgwf6wy3	51	44	a	a	NNP
cord-305263-fgwf6wy3	51	45	/	/	SYM
cord-305263-fgwf6wy3	51	46	b	b	NN
cord-305263-fgwf6wy3	51	47	genes	gene	NNS
cord-305263-fgwf6wy3	51	48	and	and	CC
cord-305263-fgwf6wy3	51	49	the	the	DT
cord-305263-fgwf6wy3	51	50	rapid	rapid	JJ
cord-305263-fgwf6wy3	51	51	production	production	NN
cord-305263-fgwf6wy3	51	52	and	and	CC
cord-305263-fgwf6wy3	51	53	secretion	secretion	NN
cord-305263-fgwf6wy3	51	54	of	of	IN
cord-305263-fgwf6wy3	51	55	these	these	DT
cord-305263-fgwf6wy3	51	56	IFNs	ifn	NNS
cord-305263-fgwf6wy3	51	57	.	.	.
cord-305263-fgwf6wy3	52	1	Upon	upon	IN
cord-305263-fgwf6wy3	52	2	viral	viral	JJ
cord-305263-fgwf6wy3	52	3	PAMP	PAMP	NNP
cord-305263-fgwf6wy3	52	4	recognition	recognition	NN
cord-305263-fgwf6wy3	52	5	,	,	,
cord-305263-fgwf6wy3	52	6	PRRs	prr	NNS
cord-305263-fgwf6wy3	52	7	are	be	VBP
cord-305263-fgwf6wy3	52	8	able	able	JJ
cord-305263-fgwf6wy3	52	9	to	to	TO
cord-305263-fgwf6wy3	52	10	trigger	trigger	VB
cord-305263-fgwf6wy3	52	11	a	a	DT
cord-305263-fgwf6wy3	52	12	phosphorylationdependent	phosphorylationdependent	NN
cord-305263-fgwf6wy3	52	13	signaling	signal	VBG
cord-305263-fgwf6wy3	52	14	cascade	cascade	NN
cord-305263-fgwf6wy3	52	15	to	to	TO
cord-305263-fgwf6wy3	52	16	activate	activate	VB
cord-305263-fgwf6wy3	52	17	IRF3	IRF3	NNP
cord-305263-fgwf6wy3	52	18	and/or	and/or	CC
cord-305263-fgwf6wy3	52	19	IRF7	IRF7	NNP
cord-305263-fgwf6wy3	52	20	.	.	.
cord-305263-fgwf6wy3	53	1	For	for	IN
cord-305263-fgwf6wy3	53	2	instance	instance	NN
cord-305263-fgwf6wy3	53	3	,	,	,
cord-305263-fgwf6wy3	53	4	endosomal	endosomal	NNP
cord-305263-fgwf6wy3	53	5	RNA	RNA	NNP
cord-305263-fgwf6wy3	53	6	/	/	SYM
cord-305263-fgwf6wy3	53	7	DNA	dna	NN
cord-305263-fgwf6wy3	53	8	-	-	HYPH
cord-305263-fgwf6wy3	53	9	sensing	sense	VBG
cord-305263-fgwf6wy3	53	10	TLR7	TLR7	NNP
cord-305263-fgwf6wy3	53	11	and	and	CC
cord-305263-fgwf6wy3	53	12	TLR9	TLR9	NNP
cord-305263-fgwf6wy3	53	13	activate	activate	VBP
cord-305263-fgwf6wy3	53	14	IRF7	IRF7	NNP
cord-305263-fgwf6wy3	53	15	via	via	IN
cord-305263-fgwf6wy3	53	16	myeloid	myeloid	JJ
cord-305263-fgwf6wy3	53	17	differentiation	differentiation	NN
cord-305263-fgwf6wy3	53	18	primary	primary	JJ
cord-305263-fgwf6wy3	53	19	response	response	NN
cord-305263-fgwf6wy3	53	20	gene	gene	NN
cord-305263-fgwf6wy3	53	21	88	88	CD
cord-305263-fgwf6wy3	53	22	(	(	-LRB-
cord-305263-fgwf6wy3	53	23	MyD88	MyD88	NNP
cord-305263-fgwf6wy3	53	24	)	)	-RRB-
cord-305263-fgwf6wy3	53	25	,	,	,
cord-305263-fgwf6wy3	53	26	whereas	whereas	IN
cord-305263-fgwf6wy3	53	27	endosomal	endosomal	NNP
cord-305263-fgwf6wy3	53	28	dsRNA	dsrna	RB
cord-305263-fgwf6wy3	53	29	-	-	HYPH
cord-305263-fgwf6wy3	53	30	binding	bind	VBG
cord-305263-fgwf6wy3	53	31	TLR3	TLR3	NNP
cord-305263-fgwf6wy3	53	32	and	and	CC
cord-305263-fgwf6wy3	53	33	RIG	rig	NN
cord-305263-fgwf6wy3	53	34	-	-	:
cord-305263-fgwf6wy3	53	35	I	I	NNP
cord-305263-fgwf6wy3	53	36	,	,	,
cord-305263-fgwf6wy3	53	37	are	be	VBP
cord-305263-fgwf6wy3	53	38	able	able	JJ
cord-305263-fgwf6wy3	53	39	to	to	TO
cord-305263-fgwf6wy3	53	40	activate	activate	VB
cord-305263-fgwf6wy3	53	41	IRF3	IRF3	NNP
cord-305263-fgwf6wy3	53	42	and	and	CC
cord-305263-fgwf6wy3	53	43	IRF7	IRF7	NNP
cord-305263-fgwf6wy3	53	44	through	through	IN
cord-305263-fgwf6wy3	53	45	TBK1	TBK1	NNP
cord-305263-fgwf6wy3	53	46	and	and	CC
cord-305263-fgwf6wy3	53	47	inhibitor	inhibitor	NN
cord-305263-fgwf6wy3	53	48	of	of	IN
cord-305263-fgwf6wy3	53	49	IKKe	IKKe	NNS
cord-305263-fgwf6wy3	53	50	.	.	.
cord-305263-fgwf6wy3	54	1	IRF3	IRF3	NNP
cord-305263-fgwf6wy3	54	2	and	and	CC
cord-305263-fgwf6wy3	54	3	IRF7	IRF7	NNP
cord-305263-fgwf6wy3	54	4	activation	activation	NN
cord-305263-fgwf6wy3	54	5	results	result	NNS
cord-305263-fgwf6wy3	54	6	in	in	IN
cord-305263-fgwf6wy3	54	7	their	-PRON-	PRP$
cord-305263-fgwf6wy3	54	8	nuclear	nuclear	JJ
cord-305263-fgwf6wy3	54	9	translocation	translocation	NN
cord-305263-fgwf6wy3	54	10	where	where	WRB
cord-305263-fgwf6wy3	54	11	they	-PRON-	PRP
cord-305263-fgwf6wy3	54	12	act	act	VBP
cord-305263-fgwf6wy3	54	13	as	as	IN
cord-305263-fgwf6wy3	54	14	transcription	transcription	NN
cord-305263-fgwf6wy3	54	15	factors	factor	NNS
cord-305263-fgwf6wy3	54	16	and	and	CC
cord-305263-fgwf6wy3	54	17	up	up	RB
cord-305263-fgwf6wy3	54	18	-	-	HYPH
cord-305263-fgwf6wy3	54	19	regulate	regulate	VB
cord-305263-fgwf6wy3	54	20	IFN	IFN	NNP
cord-305263-fgwf6wy3	54	21	-	-	HYPH
cord-305263-fgwf6wy3	54	22	a	a	NNP
cord-305263-fgwf6wy3	54	23	/	/	SYM
cord-305263-fgwf6wy3	54	24	b	b	NN
cord-305263-fgwf6wy3	54	25	gene	gene	NN
cord-305263-fgwf6wy3	54	26	expression	expression	NN
cord-305263-fgwf6wy3	54	27	.	.	.
cord-305263-fgwf6wy3	55	1	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	55	2	-	-	:
cord-305263-fgwf6wy3	55	3	a	a	NN
cord-305263-fgwf6wy3	55	4	/	/	SYM
cord-305263-fgwf6wy3	55	5	b	b	TO
cord-305263-fgwf6wy3	55	6	bind	bind	VB
cord-305263-fgwf6wy3	55	7	with	with	IN
cord-305263-fgwf6wy3	55	8	high	high	JJ
cord-305263-fgwf6wy3	55	9	affinity	affinity	NN
cord-305263-fgwf6wy3	55	10	to	to	IN
cord-305263-fgwf6wy3	55	11	the	the	DT
cord-305263-fgwf6wy3	55	12	IFNAR	IFNAR	NNP
cord-305263-fgwf6wy3	55	13	complex	complex	NN
cord-305263-fgwf6wy3	55	14	,	,	,
cord-305263-fgwf6wy3	55	15	composed	compose	VBN
cord-305263-fgwf6wy3	55	16	of	of	IN
cord-305263-fgwf6wy3	55	17	an	an	DT
cord-305263-fgwf6wy3	55	18	a	a	DT
cord-305263-fgwf6wy3	55	19	-	-	HYPH
cord-305263-fgwf6wy3	55	20	chain	chain	NN
cord-305263-fgwf6wy3	55	21	,	,	,
cord-305263-fgwf6wy3	55	22	IFNAR1	IFNAR1	NNP
cord-305263-fgwf6wy3	55	23	,	,	,
cord-305263-fgwf6wy3	55	24	which	which	WDT
cord-305263-fgwf6wy3	55	25	is	be	VBZ
cord-305263-fgwf6wy3	55	26	structurally	structurally	RB
cord-305263-fgwf6wy3	55	27	modified	modify	VBN
cord-305263-fgwf6wy3	55	28	by	by	IN
cord-305263-fgwf6wy3	55	29	cell	cell	NN
cord-305263-fgwf6wy3	55	30	membrane	membrane	NN
cord-305263-fgwf6wy3	55	31	glycosphingolipids	glycosphingolipid	NNS
cord-305263-fgwf6wy3	55	32	,	,	,
cord-305263-fgwf6wy3	55	33	galabiosylceramide	galabiosylceramide	NNP
cord-305263-fgwf6wy3	55	34	(	(	-LRB-
cord-305263-fgwf6wy3	55	35	Gb2	gb2	NN
cord-305263-fgwf6wy3	55	36	)	)	-RRB-
cord-305263-fgwf6wy3	55	37	and	and	CC
cord-305263-fgwf6wy3	55	38	globotriaosylceramide	globotriaosylceramide	NNP
cord-305263-fgwf6wy3	55	39	(	(	-LRB-
cord-305263-fgwf6wy3	55	40	Gb3	gb3	NN
cord-305263-fgwf6wy3	55	41	)	)	-RRB-
cord-305263-fgwf6wy3	55	42	to	to	TO
cord-305263-fgwf6wy3	55	43	promote	promote	VB
cord-305263-fgwf6wy3	55	44	efficient	efficient	JJ
cord-305263-fgwf6wy3	55	45	IFN	IFN	NNP
cord-305263-fgwf6wy3	55	46	binding	bind	VBG
cord-305263-fgwf6wy3	55	47	[	[	-LRB-
cord-305263-fgwf6wy3	55	48	71	71	CD
cord-305263-fgwf6wy3	55	49	,	,	,
cord-305263-fgwf6wy3	55	50	72	72	CD
cord-305263-fgwf6wy3	55	51	]	]	-RRB-
cord-305263-fgwf6wy3	55	52	,	,	,
cord-305263-fgwf6wy3	55	53	and	and	CC
cord-305263-fgwf6wy3	55	54	a	a	DT
cord-305263-fgwf6wy3	55	55	b	b	NN
cord-305263-fgwf6wy3	55	56	-	-	HYPH
cord-305263-fgwf6wy3	55	57	chain	chain	NN
cord-305263-fgwf6wy3	55	58	,	,	,
cord-305263-fgwf6wy3	55	59	IFNAR2	IFNAR2	NNP
cord-305263-fgwf6wy3	55	60	.	.	.
cord-305263-fgwf6wy3	56	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	56	2	binding	bind	VBG
cord-305263-fgwf6wy3	56	3	to	to	IN
cord-305263-fgwf6wy3	56	4	IFNAR	IFNAR	NNP
cord-305263-fgwf6wy3	56	5	induces	induce	VBZ
cord-305263-fgwf6wy3	56	6	phosphorylation	phosphorylation	NN
cord-305263-fgwf6wy3	56	7	of	of	IN
cord-305263-fgwf6wy3	56	8	the	the	DT
cord-305263-fgwf6wy3	56	9	receptor	receptor	NN
cord-305263-fgwf6wy3	56	10	-	-	HYPH
cord-305263-fgwf6wy3	56	11	bound	bind	VBN
cord-305263-fgwf6wy3	56	12	tyrosine	tyrosine	NN
cord-305263-fgwf6wy3	56	13	kinases	kinase	NNS
cord-305263-fgwf6wy3	56	14	,	,	,
cord-305263-fgwf6wy3	56	15	tyrosine	tyrosine	NN
cord-305263-fgwf6wy3	56	16	kinase	kinase	NN
cord-305263-fgwf6wy3	56	17	2	2	CD
cord-305263-fgwf6wy3	56	18	(	(	-LRB-
cord-305263-fgwf6wy3	56	19	TYK2	TYK2	NNP
cord-305263-fgwf6wy3	56	20	)	)	-RRB-
cord-305263-fgwf6wy3	56	21	and	and	CC
cord-305263-fgwf6wy3	56	22	JAK1	JAK1	NNP
cord-305263-fgwf6wy3	56	23	,	,	,
cord-305263-fgwf6wy3	56	24	leading	lead	VBG
cord-305263-fgwf6wy3	56	25	to	to	IN
cord-305263-fgwf6wy3	56	26	the	the	DT
cord-305263-fgwf6wy3	56	27	subsequent	subsequent	JJ
cord-305263-fgwf6wy3	56	28	regulation	regulation	NN
cord-305263-fgwf6wy3	56	29	of	of	IN
cord-305263-fgwf6wy3	56	30	:	:	:
cord-305263-fgwf6wy3	56	31	(	(	-LRB-
cord-305263-fgwf6wy3	56	32	a	a	LS
cord-305263-fgwf6wy3	56	33	)	)	-RRB-
cord-305263-fgwf6wy3	56	34	protein	protein	NN
cord-305263-fgwf6wy3	56	35	synthesis	synthesis	NN
cord-305263-fgwf6wy3	56	36	via	via	IN
cord-305263-fgwf6wy3	56	37	the	the	DT
cord-305263-fgwf6wy3	56	38	activation	activation	NN
cord-305263-fgwf6wy3	56	39	of	of	IN
cord-305263-fgwf6wy3	56	40	PI3	PI3	NNP
cord-305263-fgwf6wy3	56	41	K	K	NNP
cord-305263-fgwf6wy3	56	42	and	and	CC
cord-305263-fgwf6wy3	56	43	mammalian	mammalian	JJ
cord-305263-fgwf6wy3	56	44	target	target	NN
cord-305263-fgwf6wy3	56	45	of	of	IN
cord-305263-fgwf6wy3	56	46	rapamycin	rapamycin	NNP
cord-305263-fgwf6wy3	56	47	(	(	-LRB-
cord-305263-fgwf6wy3	56	48	mTOR	mTOR	NNP
cord-305263-fgwf6wy3	56	49	)	)	-RRB-
cord-305263-fgwf6wy3	56	50	;	;	:
cord-305263-fgwf6wy3	56	51	(	(	-LRB-
cord-305263-fgwf6wy3	56	52	b	b	NN
cord-305263-fgwf6wy3	56	53	)	)	-RRB-
cord-305263-fgwf6wy3	56	54	histone	histone	NN
cord-305263-fgwf6wy3	56	55	modification	modification	NN
cord-305263-fgwf6wy3	56	56	,	,	,
cord-305263-fgwf6wy3	56	57	via	via	IN
cord-305263-fgwf6wy3	56	58	the	the	DT
cord-305263-fgwf6wy3	56	59	activation	activation	NN
cord-305263-fgwf6wy3	56	60	of	of	IN
cord-305263-fgwf6wy3	56	61	p38	p38	CD
cord-305263-fgwf6wy3	56	62	MAPK	MAPK	NNP
cord-305263-fgwf6wy3	56	63	;	;	:
cord-305263-fgwf6wy3	56	64	and	and	CC
cord-305263-fgwf6wy3	56	65	(	(	-LRB-
cord-305263-fgwf6wy3	56	66	c	c	NN
cord-305263-fgwf6wy3	56	67	)	)	-RRB-
cord-305263-fgwf6wy3	56	68	gene	gene	NN
cord-305263-fgwf6wy3	56	69	expression	expression	NN
cord-305263-fgwf6wy3	56	70	via	via	IN
cord-305263-fgwf6wy3	56	71	the	the	DT
cord-305263-fgwf6wy3	56	72	phosphorylation	phosphorylation	NN
cord-305263-fgwf6wy3	56	73	of	of	IN
cord-305263-fgwf6wy3	56	74	STAT	stat	NN
cord-305263-fgwf6wy3	56	75	proteins	protein	NNS
cord-305263-fgwf6wy3	56	76	and	and	CC
cord-305263-fgwf6wy3	56	77	MAPK	MAPK	NNP
cord-305263-fgwf6wy3	56	78	activation	activation	NN
cord-305263-fgwf6wy3	56	79	.	.	.
cord-305263-fgwf6wy3	57	1	TYK2-and	TYK2-and	NNP
cord-305263-fgwf6wy3	57	2	JAK1-mediated	JAK1-mediated	NNP
cord-305263-fgwf6wy3	57	3	activation	activation	NN
cord-305263-fgwf6wy3	57	4	of	of	IN
cord-305263-fgwf6wy3	57	5	insulin	insulin	NN
cord-305263-fgwf6wy3	57	6	receptor	receptor	NN
cord-305263-fgwf6wy3	57	7	substrate	substrate	NN
cord-305263-fgwf6wy3	57	8	(	(	-LRB-
cord-305263-fgwf6wy3	57	9	IRS	IRS	NNP
cord-305263-fgwf6wy3	57	10	)	)	-RRB-
cord-305263-fgwf6wy3	57	11	1	1	CD
cord-305263-fgwf6wy3	57	12	and	and	CC
cord-305263-fgwf6wy3	57	13	IRS2	IRS2	NNP
cord-305263-fgwf6wy3	57	14	is	be	VBZ
cord-305263-fgwf6wy3	57	15	required	require	VBN
cord-305263-fgwf6wy3	57	16	for	for	IN
cord-305263-fgwf6wy3	57	17	recruitment	recruitment	NN
cord-305263-fgwf6wy3	57	18	and	and	CC
cord-305263-fgwf6wy3	57	19	activation	activation	NN
cord-305263-fgwf6wy3	57	20	of	of	IN
cord-305263-fgwf6wy3	57	21	PI3K.	PI3K.	NNP
cord-305263-fgwf6wy3	57	22	PI3	PI3	NNP
cord-305263-fgwf6wy3	57	23	K	K	NNP
cord-305263-fgwf6wy3	57	24	phosphorylates	phosphorylate	VBZ
cord-305263-fgwf6wy3	57	25	AKT	AKT	NNP
cord-305263-fgwf6wy3	57	26	,	,	,
cord-305263-fgwf6wy3	57	27	which	which	WDT
cord-305263-fgwf6wy3	57	28	inactivates	inactivate	VBZ
cord-305263-fgwf6wy3	57	29	inhibitors	inhibitor	NNS
cord-305263-fgwf6wy3	57	30	of	of	IN
cord-305263-fgwf6wy3	57	31	mTOR	mTOR	NNP
cord-305263-fgwf6wy3	57	32	,	,	,
cord-305263-fgwf6wy3	57	33	tuberous	tuberous	JJ
cord-305263-fgwf6wy3	57	34	sclerosis	sclerosis	NN
cord-305263-fgwf6wy3	57	35	protein	protein	NN
cord-305263-fgwf6wy3	57	36	(	(	-LRB-
cord-305263-fgwf6wy3	57	37	TSC	TSC	NNP
cord-305263-fgwf6wy3	57	38	)	)	-RRB-
cord-305263-fgwf6wy3	57	39	1	1	CD
cord-305263-fgwf6wy3	57	40	and	and	CC
cord-305263-fgwf6wy3	57	41	TSC2	TSC2	NNP
cord-305263-fgwf6wy3	57	42	[	[	-LRB-
cord-305263-fgwf6wy3	57	43	73	73	CD
cord-305263-fgwf6wy3	57	44	]	]	-RRB-
cord-305263-fgwf6wy3	57	45	.	.	.
cord-305263-fgwf6wy3	58	1	mTOR	mTOR	NNP
cord-305263-fgwf6wy3	58	2	activates	activate	VBZ
cord-305263-fgwf6wy3	58	3	the	the	DT
cord-305263-fgwf6wy3	58	4	serine/	serine/	CD
cord-305263-fgwf6wy3	58	5	threonine	threonine	NN
cord-305263-fgwf6wy3	58	6	kinase	kinase	NN
cord-305263-fgwf6wy3	59	1	p70S6	p70s6	XX
cord-305263-fgwf6wy3	59	2	K	k	XX
cord-305263-fgwf6wy3	59	3	,	,	,
cord-305263-fgwf6wy3	59	4	and	and	CC
cord-305263-fgwf6wy3	59	5	inactivates	inactivate	VBZ
cord-305263-fgwf6wy3	59	6	eukaryotic	eukaryotic	JJ
cord-305263-fgwf6wy3	59	7	translation	translation	NN
cord-305263-fgwf6wy3	59	8	initiation	initiation	NN
cord-305263-fgwf6wy3	59	9	factor	factor	NN
cord-305263-fgwf6wy3	59	10	4E	4E	NNP
cord-305263-fgwf6wy3	59	11	-	-	HYPH
cord-305263-fgwf6wy3	59	12	binding	bind	VBG
cord-305263-fgwf6wy3	59	13	protein	protein	NN
cord-305263-fgwf6wy3	59	14	1	1	CD
cord-305263-fgwf6wy3	59	15	(	(	-LRB-
cord-305263-fgwf6wy3	59	16	4E	4E	NNP
cord-305263-fgwf6wy3	59	17	-	-	HYPH
cord-305263-fgwf6wy3	59	18	BP1	BP1	NNP
cord-305263-fgwf6wy3	59	19	)	)	-RRB-
cord-305263-fgwf6wy3	59	20	,	,	,
cord-305263-fgwf6wy3	59	21	to	to	TO
cord-305263-fgwf6wy3	59	22	upregulate	upregulate	VB
cord-305263-fgwf6wy3	59	23	cap	cap	NN
cord-305263-fgwf6wy3	59	24	-	-	HYPH
cord-305263-fgwf6wy3	59	25	dependent	dependent	JJ
cord-305263-fgwf6wy3	59	26	mRNA	mRNA	NNP
cord-305263-fgwf6wy3	59	27	translation	translation	NN
cord-305263-fgwf6wy3	59	28	and	and	CC
cord-305263-fgwf6wy3	59	29	protein	protein	NN
cord-305263-fgwf6wy3	59	30	synthesis	synthesis	NN
cord-305263-fgwf6wy3	59	31	.	.	.
cord-305263-fgwf6wy3	60	1	p38	p38	NNP
cord-305263-fgwf6wy3	60	2	is	be	VBZ
cord-305263-fgwf6wy3	60	3	activated	activate	VBN
cord-305263-fgwf6wy3	60	4	downstream	downstream	RB
cord-305263-fgwf6wy3	60	5	of	of	IN
cord-305263-fgwf6wy3	60	6	MAPK	MAPK	NNP
cord-305263-fgwf6wy3	60	7	kinases	kinase	NNS
cord-305263-fgwf6wy3	60	8	3	3	CD
cord-305263-fgwf6wy3	60	9	and	and	CC
cord-305263-fgwf6wy3	60	10	6	6	CD
cord-305263-fgwf6wy3	60	11	(	(	-LRB-
cord-305263-fgwf6wy3	60	12	MKK3/6	MKK3/6	NNP
cord-305263-fgwf6wy3	60	13	)	)	-RRB-
cord-305263-fgwf6wy3	60	14	and	and	CC
cord-305263-fgwf6wy3	60	15	regulates	regulate	VBZ
cord-305263-fgwf6wy3	60	16	histone	histone	NN
cord-305263-fgwf6wy3	60	17	modification	modification	NN
cord-305263-fgwf6wy3	60	18	and	and	CC
cord-305263-fgwf6wy3	60	19	gene	gene	NN
cord-305263-fgwf6wy3	60	20	expression	expression	NN
cord-305263-fgwf6wy3	60	21	through	through	IN
cord-305263-fgwf6wy3	60	22	mitogen	mitogen	NN
cord-305263-fgwf6wy3	60	23	-	-	HYPH
cord-305263-fgwf6wy3	60	24	and	and	CC
cord-305263-fgwf6wy3	60	25	stress	stress	NN
cord-305263-fgwf6wy3	60	26	-	-	HYPH
cord-305263-fgwf6wy3	60	27	activated	activate	VBN
cord-305263-fgwf6wy3	60	28	protein	protein	NN
cord-305263-fgwf6wy3	60	29	kinase	kinase	NN
cord-305263-fgwf6wy3	60	30	(	(	-LRB-
cord-305263-fgwf6wy3	60	31	Msk	Msk	NNP
cord-305263-fgwf6wy3	60	32	)	)	-RRB-
cord-305263-fgwf6wy3	60	33	1	1	CD
cord-305263-fgwf6wy3	60	34	and	and	CC
cord-305263-fgwf6wy3	60	35	Msk2	Msk2	NNP
cord-305263-fgwf6wy3	60	36	.	.	.
cord-305263-fgwf6wy3	61	1	In	in	IN
cord-305263-fgwf6wy3	61	2	addition	addition	NN
cord-305263-fgwf6wy3	61	3	,	,	,
cord-305263-fgwf6wy3	61	4	IFN	IFN	NNP
cord-305263-fgwf6wy3	61	5	signaling	signal	VBG
cord-305263-fgwf6wy3	61	6	invokes	invoke	VBZ
cord-305263-fgwf6wy3	61	7	promyelocytic	promyelocytic	JJ
cord-305263-fgwf6wy3	61	8	leukemia	leukemia	NN
cord-305263-fgwf6wy3	61	9	zinc	zinc	NN
cord-305263-fgwf6wy3	61	10	finger	finger	NN
cord-305263-fgwf6wy3	61	11	(	(	-LRB-
cord-305263-fgwf6wy3	61	12	PLZF	PLZF	NNP
cord-305263-fgwf6wy3	61	13	)	)	-RRB-
cord-305263-fgwf6wy3	61	14	protein	protein	NN
cord-305263-fgwf6wy3	61	15	-	-	HYPH
cord-305263-fgwf6wy3	61	16	mediated	mediate	VBN
cord-305263-fgwf6wy3	61	17	histone	histone	NN
cord-305263-fgwf6wy3	61	18	modification	modification	NN
cord-305263-fgwf6wy3	61	19	to	to	TO
cord-305263-fgwf6wy3	61	20	regulate	regulate	VB
cord-305263-fgwf6wy3	61	21	ISG	ISG	NNP
cord-305263-fgwf6wy3	61	22	expression	expression	NN
cord-305263-fgwf6wy3	61	23	[	[	-LRB-
cord-305263-fgwf6wy3	61	24	74	74	CD
cord-305263-fgwf6wy3	61	25	]	]	-RRB-
cord-305263-fgwf6wy3	61	26	.	.	.
cord-305263-fgwf6wy3	62	1	Phosphorylation	Phosphorylation	NNP
cord-305263-fgwf6wy3	62	2	of	of	IN
cord-305263-fgwf6wy3	62	3	STAT	stat	NN
cord-305263-fgwf6wy3	62	4	proteins	protein	NNS
cord-305263-fgwf6wy3	62	5	results	result	NNS
cord-305263-fgwf6wy3	62	6	in	in	IN
cord-305263-fgwf6wy3	62	7	their	-PRON-	PRP$
cord-305263-fgwf6wy3	62	8	dimerization	dimerization	NN
cord-305263-fgwf6wy3	62	9	and	and	CC
cord-305263-fgwf6wy3	62	10	IFN	IFN	NNP
cord-305263-fgwf6wy3	62	11	-	-	HYPH
cord-305263-fgwf6wy3	62	12	stimulated	stimulate	VBN
cord-305263-fgwf6wy3	62	13	gene	gene	NN
cord-305263-fgwf6wy3	62	14	factor	factor	NN
cord-305263-fgwf6wy3	62	15	(	(	-LRB-
cord-305263-fgwf6wy3	62	16	ISGF	ISGF	NNP
cord-305263-fgwf6wy3	62	17	)	)	-RRB-
cord-305263-fgwf6wy3	62	18	formation	formation	NN
cord-305263-fgwf6wy3	62	19	.	.	.
cord-305263-fgwf6wy3	63	1	STAT	stat	NN
cord-305263-fgwf6wy3	63	2	complexes	complex	NNS
cord-305263-fgwf6wy3	63	3	translocate	translocate	VBP
cord-305263-fgwf6wy3	63	4	to	to	IN
cord-305263-fgwf6wy3	63	5	the	the	DT
cord-305263-fgwf6wy3	63	6	nucleus	nucleus	NN
cord-305263-fgwf6wy3	63	7	and	and	CC
cord-305263-fgwf6wy3	63	8	bind	bind	VB
cord-305263-fgwf6wy3	63	9	to	to	IN
cord-305263-fgwf6wy3	63	10	specific	specific	JJ
cord-305263-fgwf6wy3	63	11	gene	gene	NN
cord-305263-fgwf6wy3	63	12	elements	element	NNS
cord-305263-fgwf6wy3	63	13	in	in	IN
cord-305263-fgwf6wy3	63	14	the	the	DT
cord-305263-fgwf6wy3	63	15	promoters	promoter	NNS
cord-305263-fgwf6wy3	63	16	of	of	IN
cord-305263-fgwf6wy3	63	17	ISGs	ISGs	NNPS
cord-305263-fgwf6wy3	63	18	,	,	,
cord-305263-fgwf6wy3	63	19	IFN	IFN	NNP
cord-305263-fgwf6wy3	63	20	-	-	HYPH
cord-305263-fgwf6wy3	63	21	g	g	NNP
cord-305263-fgwf6wy3	63	22	activated	activate	VBN
cord-305263-fgwf6wy3	63	23	sequence	sequence	NN
cord-305263-fgwf6wy3	63	24	(	(	-LRB-
cord-305263-fgwf6wy3	63	25	GAS	gas	NN
cord-305263-fgwf6wy3	63	26	)	)	-RRB-
cord-305263-fgwf6wy3	63	27	and	and	CC
cord-305263-fgwf6wy3	63	28	IFN	IFN	NNP
cord-305263-fgwf6wy3	63	29	-	-	HYPH
cord-305263-fgwf6wy3	63	30	sensitive	sensitive	JJ
cord-305263-fgwf6wy3	63	31	response	response	NN
cord-305263-fgwf6wy3	63	32	element	element	NN
cord-305263-fgwf6wy3	63	33	(	(	-LRB-
cord-305263-fgwf6wy3	63	34	ISRE	ISRE	NNP
cord-305263-fgwf6wy3	63	35	)	)	-RRB-
cord-305263-fgwf6wy3	63	36	,	,	,
cord-305263-fgwf6wy3	63	37	to	to	TO
cord-305263-fgwf6wy3	63	38	induce	induce	VB
cord-305263-fgwf6wy3	63	39	expression	expression	NN
cord-305263-fgwf6wy3	63	40	of	of	IN
cord-305263-fgwf6wy3	63	41	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	63	42	genes	gene	NNS
cord-305263-fgwf6wy3	63	43	.	.	.
cord-305263-fgwf6wy3	64	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	64	2	therapy	therapy	NN
cord-305263-fgwf6wy3	64	3	as	as	IN
cord-305263-fgwf6wy3	64	4	a	a	DT
cord-305263-fgwf6wy3	64	5	first	first	JJ
cord-305263-fgwf6wy3	64	6	-	-	HYPH
cord-305263-fgwf6wy3	64	7	line	line	NN
cord-305263-fgwf6wy3	64	8	treatment	treatment	NN
cord-305263-fgwf6wy3	64	9	against	against	IN
cord-305263-fgwf6wy3	64	10	newly	newly	RB
cord-305263-fgwf6wy3	64	11	emerging	emerge	VBG
cord-305263-fgwf6wy3	64	12	or	or	CC
cord-305263-fgwf6wy3	64	13	re	re	VB
cord-305263-fgwf6wy3	64	14	-	-	JJ
cord-305263-fgwf6wy3	64	15	emerging	emerge	VBG
cord-305263-fgwf6wy3	64	16	virus	virus	NN
cord-305263-fgwf6wy3	64	17	outbreaks	outbreak	NNS
cord-305263-fgwf6wy3	64	18	:	:	:
cord-305263-fgwf6wy3	64	19	SARS	SARS	NNP
cord-305263-fgwf6wy3	64	20	-	-	HYPH
cord-305263-fgwf6wy3	64	21	CoV	CoV	NNP
cord-305263-fgwf6wy3	65	1	The	the	DT
cord-305263-fgwf6wy3	65	2	SARS	SARS	NNP
cord-305263-fgwf6wy3	65	3	-	-	HYPH
cord-305263-fgwf6wy3	65	4	CoV	CoV	NNP
cord-305263-fgwf6wy3	65	5	outbreak	outbreak	NN
cord-305263-fgwf6wy3	65	6	originated	originate	VBD
cord-305263-fgwf6wy3	65	7	in	in	IN
cord-305263-fgwf6wy3	65	8	Hong	Hong	NNP
cord-305263-fgwf6wy3	65	9	Kong	Kong	NNP
cord-305263-fgwf6wy3	65	10	in	in	IN
cord-305263-fgwf6wy3	65	11	late	late	JJ
cord-305263-fgwf6wy3	65	12	2002	2002	CD
cord-305263-fgwf6wy3	65	13	-	-	SYM
cord-305263-fgwf6wy3	65	14	2003	2003	CD
cord-305263-fgwf6wy3	65	15	and	and	CC
cord-305263-fgwf6wy3	65	16	resulted	result	VBD
cord-305263-fgwf6wy3	65	17	in	in	IN
cord-305263-fgwf6wy3	65	18	>	>	XX
cord-305263-fgwf6wy3	65	19	8000	8000	CD
cord-305263-fgwf6wy3	65	20	cases	case	NNS
cord-305263-fgwf6wy3	65	21	of	of	IN
cord-305263-fgwf6wy3	65	22	disease	disease	NN
cord-305263-fgwf6wy3	65	23	worldwide	worldwide	RB
cord-305263-fgwf6wy3	65	24	,	,	,
cord-305263-fgwf6wy3	65	25	with	with	IN
cord-305263-fgwf6wy3	65	26	a	a	DT
cord-305263-fgwf6wy3	65	27	9.6	9.6	CD
cord-305263-fgwf6wy3	65	28	%	%	NN
cord-305263-fgwf6wy3	65	29	mortality	mortality	NN
cord-305263-fgwf6wy3	65	30	rate	rate	NN
cord-305263-fgwf6wy3	65	31	between	between	IN
cord-305263-fgwf6wy3	65	32	November	November	NNP
cord-305263-fgwf6wy3	65	33	2002	2002	CD
cord-305263-fgwf6wy3	65	34	and	and	CC
cord-305263-fgwf6wy3	65	35	July	July	NNP
cord-305263-fgwf6wy3	65	36	2003	2003	CD
cord-305263-fgwf6wy3	65	37	(	(	-LRB-
cord-305263-fgwf6wy3	65	38	http://www.who.int/csr/sars/country/	http://www.who.int/csr/sars/country/	NNP
cord-305263-fgwf6wy3	65	39	table2004_04_21	table2004_04_21	CD
cord-305263-fgwf6wy3	65	40	/	/	SYM
cord-305263-fgwf6wy3	65	41	en	en	NN
cord-305263-fgwf6wy3	65	42	/	/	SYM
cord-305263-fgwf6wy3	65	43	index.html	index.html	NNP
cord-305263-fgwf6wy3	65	44	)	)	-RRB-
cord-305263-fgwf6wy3	65	45	.	.	.
cord-305263-fgwf6wy3	66	1	SARS	SARS	NNP
cord-305263-fgwf6wy3	66	2	-	-	HYPH
cord-305263-fgwf6wy3	66	3	CoV	CoV	NNP
cord-305263-fgwf6wy3	66	4	is	be	VBZ
cord-305263-fgwf6wy3	66	5	a	a	DT
cord-305263-fgwf6wy3	66	6	singlestranded	singlestrande	VBN
cord-305263-fgwf6wy3	66	7	RNA	RNA	NNP
cord-305263-fgwf6wy3	66	8	virus	virus	NN
cord-305263-fgwf6wy3	66	9	that	that	WDT
cord-305263-fgwf6wy3	66	10	encodes	encode	VBZ
cord-305263-fgwf6wy3	66	11	in	in	IN
cord-305263-fgwf6wy3	66	12	its	-PRON-	PRP$
cord-305263-fgwf6wy3	66	13	genome	genome	NN
cord-305263-fgwf6wy3	66	14	virulence	virulence	NN
cord-305263-fgwf6wy3	66	15	factors	factor	NNS
cord-305263-fgwf6wy3	66	16	that	that	WDT
cord-305263-fgwf6wy3	66	17	antagonize	antagonize	VBP
cord-305263-fgwf6wy3	66	18	the	the	DT
cord-305263-fgwf6wy3	66	19	IFN	IFN	NNP
cord-305263-fgwf6wy3	66	20	-	-	HYPH
cord-305263-fgwf6wy3	66	21	a	a	NN
cord-305263-fgwf6wy3	66	22	/	/	SYM
cord-305263-fgwf6wy3	66	23	b	b	NN
cord-305263-fgwf6wy3	66	24	response	response	NN
cord-305263-fgwf6wy3	66	25	.	.	.
cord-305263-fgwf6wy3	67	1	In	in	IN
cord-305263-fgwf6wy3	67	2	infected	infected	JJ
cord-305263-fgwf6wy3	67	3	host	host	NN
cord-305263-fgwf6wy3	67	4	cells	cell	NNS
cord-305263-fgwf6wy3	67	5	,	,	,
cord-305263-fgwf6wy3	67	6	SARS	SARS	NNP
cord-305263-fgwf6wy3	67	7	-	-	HYPH
cord-305263-fgwf6wy3	67	8	CoV	CoV	NNP
cord-305263-fgwf6wy3	67	9	expresses	express	VBZ
cord-305263-fgwf6wy3	67	10	the	the	DT
cord-305263-fgwf6wy3	67	11	nonstructural	nonstructural	JJ
cord-305263-fgwf6wy3	67	12	protein	protein	NN
cord-305263-fgwf6wy3	67	13	(	(	-LRB-
cord-305263-fgwf6wy3	67	14	Nsp	Nsp	NNP
cord-305263-fgwf6wy3	67	15	)	)	-RRB-
cord-305263-fgwf6wy3	67	16	1	1	CD
cord-305263-fgwf6wy3	67	17	and	and	CC
cord-305263-fgwf6wy3	67	18	Nsp3	Nsp3	NNS
cord-305263-fgwf6wy3	67	19	.	.	.
cord-305263-fgwf6wy3	68	1	Nsp1	Nsp1	NNP
cord-305263-fgwf6wy3	68	2	suppresses	suppress	VBZ
cord-305263-fgwf6wy3	68	3	host	host	NN
cord-305263-fgwf6wy3	68	4	gene	gene	NN
cord-305263-fgwf6wy3	68	5	expression	expression	NN
cord-305263-fgwf6wy3	68	6	by	by	IN
cord-305263-fgwf6wy3	68	7	disrupting	disrupt	VBG
cord-305263-fgwf6wy3	68	8	mRNA	mRNA	NNP
cord-305263-fgwf6wy3	68	9	translation	translation	NN
cord-305263-fgwf6wy3	68	10	and	and	CC
cord-305263-fgwf6wy3	68	11	by	by	IN
cord-305263-fgwf6wy3	68	12	upregulating	upregulate	VBG
cord-305263-fgwf6wy3	68	13	mRNA	mRNA	NNP
cord-305263-fgwf6wy3	68	14	degradation	degradation	NN
cord-305263-fgwf6wy3	68	15	[	[	-LRB-
cord-305263-fgwf6wy3	68	16	14	14	CD
cord-305263-fgwf6wy3	68	17	,	,	,
cord-305263-fgwf6wy3	68	18	22	22	CD
cord-305263-fgwf6wy3	68	19	]	]	-RRB-
cord-305263-fgwf6wy3	68	20	.	.	.
cord-305263-fgwf6wy3	69	1	Immunoprecipitation	immunoprecipitation	NN
cord-305263-fgwf6wy3	69	2	and	and	CC
cord-305263-fgwf6wy3	69	3	luciferase	luciferase	JJ
cord-305263-fgwf6wy3	69	4	reporter	reporter	NN
cord-305263-fgwf6wy3	69	5	studies	study	NNS
cord-305263-fgwf6wy3	69	6	have	have	VBP
cord-305263-fgwf6wy3	69	7	shown	show	VBN
cord-305263-fgwf6wy3	69	8	that	that	IN
cord-305263-fgwf6wy3	69	9	Nsp1	Nsp1	NNP
cord-305263-fgwf6wy3	69	10	directly	directly	RB
cord-305263-fgwf6wy3	69	11	associates	associate	VBZ
cord-305263-fgwf6wy3	69	12	with	with	IN
cord-305263-fgwf6wy3	69	13	the	the	DT
cord-305263-fgwf6wy3	69	14	40S	40s	CD
cord-305263-fgwf6wy3	69	15	ribosomal	ribosomal	JJ
cord-305263-fgwf6wy3	69	16	subunit	subunit	NN
cord-305263-fgwf6wy3	69	17	to	to	TO
cord-305263-fgwf6wy3	69	18	inhibit	inhibit	VB
cord-305263-fgwf6wy3	69	19	its	-PRON-	PRP$
cord-305263-fgwf6wy3	69	20	translational	translational	JJ
cord-305263-fgwf6wy3	69	21	activity	activity	NN
cord-305263-fgwf6wy3	69	22	[	[	-LRB-
cord-305263-fgwf6wy3	69	23	22	22	CD
cord-305263-fgwf6wy3	69	24	]	]	-RRB-
cord-305263-fgwf6wy3	69	25	.	.	.
cord-305263-fgwf6wy3	70	1	In	in	IN
cord-305263-fgwf6wy3	70	2	addition	addition	NN
cord-305263-fgwf6wy3	70	3	,	,	,
cord-305263-fgwf6wy3	70	4	the	the	DT
cord-305263-fgwf6wy3	70	5	Nsp1	Nsp1	NNP
cord-305263-fgwf6wy3	70	6	-	-	HYPH
cord-305263-fgwf6wy3	70	7	40S	40s	CD
cord-305263-fgwf6wy3	70	8	complex	complex	NN
cord-305263-fgwf6wy3	70	9	is	be	VBZ
cord-305263-fgwf6wy3	70	10	able	able	JJ
cord-305263-fgwf6wy3	70	11	to	to	TO
cord-305263-fgwf6wy3	70	12	modify	modify	VB
cord-305263-fgwf6wy3	70	13	mature	mature	JJ
cord-305263-fgwf6wy3	70	14	5	5	CD
cord-305263-fgwf6wy3	70	15	0	0	CD
cord-305263-fgwf6wy3	70	16	-capped	-capped	JJ
cord-305263-fgwf6wy3	70	17	RNAs	rna	NNS
cord-305263-fgwf6wy3	70	18	to	to	TO
cord-305263-fgwf6wy3	70	19	limit	limit	VB
cord-305263-fgwf6wy3	70	20	translation	translation	NN
cord-305263-fgwf6wy3	70	21	and	and	CC
cord-305263-fgwf6wy3	70	22	promote	promote	VB
cord-305263-fgwf6wy3	70	23	degradation	degradation	NN
cord-305263-fgwf6wy3	70	24	[	[	-LRB-
cord-305263-fgwf6wy3	70	25	22	22	CD
cord-305263-fgwf6wy3	70	26	]	]	-RRB-
cord-305263-fgwf6wy3	70	27	.	.	.
cord-305263-fgwf6wy3	71	1	In	in	IN
cord-305263-fgwf6wy3	71	2	the	the	DT
cord-305263-fgwf6wy3	71	3	context	context	NN
cord-305263-fgwf6wy3	71	4	of	of	IN
cord-305263-fgwf6wy3	71	5	an	an	DT
cord-305263-fgwf6wy3	71	6	IFN	IFN	NNP
cord-305263-fgwf6wy3	71	7	response	response	NN
cord-305263-fgwf6wy3	71	8	,	,	,
cord-305263-fgwf6wy3	71	9	these	these	DT
cord-305263-fgwf6wy3	71	10	antagonistic	antagonistic	JJ
cord-305263-fgwf6wy3	71	11	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	71	12	of	of	IN
cord-305263-fgwf6wy3	71	13	Nsp1	Nsp1	NNP
cord-305263-fgwf6wy3	71	14	on	on	IN
cord-305263-fgwf6wy3	71	15	host	host	NN
cord-305263-fgwf6wy3	71	16	gene	gene	NN
cord-305263-fgwf6wy3	71	17	expression	expression	NN
cord-305263-fgwf6wy3	71	18	and	and	CC
cord-305263-fgwf6wy3	71	19	protein	protein	NN
cord-305263-fgwf6wy3	71	20	synthesis	synthesis	NN
cord-305263-fgwf6wy3	71	21	inhibit	inhibit	VBP
cord-305263-fgwf6wy3	71	22	IFN	IFN	NNP
cord-305263-fgwf6wy3	71	23	-	-	HYPH
cord-305263-fgwf6wy3	71	24	a	a	NNP
cord-305263-fgwf6wy3	71	25	/	/	SYM
cord-305263-fgwf6wy3	71	26	b	b	NN
cord-305263-fgwf6wy3	71	27	expression	expression	NN
cord-305263-fgwf6wy3	71	28	and	and	CC
cord-305263-fgwf6wy3	71	29	production	production	NN
cord-305263-fgwf6wy3	71	30	[	[	-LRB-
cord-305263-fgwf6wy3	71	31	14	14	CD
cord-305263-fgwf6wy3	71	32	]	]	-RRB-
cord-305263-fgwf6wy3	71	33	.	.	.
cord-305263-fgwf6wy3	72	1	In	in	IN
cord-305263-fgwf6wy3	72	2	vitro	vitro	FW
cord-305263-fgwf6wy3	72	3	,	,	,
cord-305263-fgwf6wy3	72	4	Nsp1	Nsp1	NNP
cord-305263-fgwf6wy3	72	5	also	also	RB
cord-305263-fgwf6wy3	72	6	inhibits	inhibit	VBZ
cord-305263-fgwf6wy3	72	7	signal	signal	NN
cord-305263-fgwf6wy3	72	8	transducer	transducer	NN
cord-305263-fgwf6wy3	72	9	and	and	CC
cord-305263-fgwf6wy3	72	10	activator	activator	NN
cord-305263-fgwf6wy3	72	11	of	of	IN
cord-305263-fgwf6wy3	72	12	transcription	transcription	NN
cord-305263-fgwf6wy3	72	13	(	(	-LRB-
cord-305263-fgwf6wy3	72	14	STAT	stat	NN
cord-305263-fgwf6wy3	72	15	)	)	-RRB-
cord-305263-fgwf6wy3	72	16	1	1	CD
cord-305263-fgwf6wy3	72	17	protein	protein	NN
cord-305263-fgwf6wy3	72	18	phosphorylation	phosphorylation	NN
cord-305263-fgwf6wy3	72	19	induced	induce	VBN
cord-305263-fgwf6wy3	72	20	by	by	IN
cord-305263-fgwf6wy3	72	21	IFN	IFN	NNP
cord-305263-fgwf6wy3	72	22	-	-	:
cord-305263-fgwf6wy3	72	23	a	a	DT
cord-305263-fgwf6wy3	72	24	treatment	treatment	NN
cord-305263-fgwf6wy3	72	25	[	[	-LRB-
cord-305263-fgwf6wy3	72	26	23	23	CD
cord-305263-fgwf6wy3	72	27	]	]	-RRB-
cord-305263-fgwf6wy3	72	28	.	.	.
cord-305263-fgwf6wy3	73	1	Both	both	DT
cord-305263-fgwf6wy3	73	2	Nsp1	Nsp1	NNP
cord-305263-fgwf6wy3	73	3	and	and	CC
cord-305263-fgwf6wy3	73	4	Nsp3	Nsp3	NNS
cord-305263-fgwf6wy3	73	5	inhibit	inhibit	VBP
cord-305263-fgwf6wy3	73	6	interferon	interferon	NN
cord-305263-fgwf6wy3	73	7	regulatory	regulatory	JJ
cord-305263-fgwf6wy3	73	8	factor	factor	NN
cord-305263-fgwf6wy3	74	1	(	(	-LRB-
cord-305263-fgwf6wy3	74	2	IRF	IRF	NNP
cord-305263-fgwf6wy3	74	3	)	)	-RRB-
cord-305263-fgwf6wy3	74	4	3	3	CD
cord-305263-fgwf6wy3	74	5	and	and	CC
cord-305263-fgwf6wy3	74	6	IRF7	IRF7	NNP
cord-305263-fgwf6wy3	74	7	activation	activation	NN
cord-305263-fgwf6wy3	74	8	to	to	TO
cord-305263-fgwf6wy3	74	9	downregulate	downregulate	VB
cord-305263-fgwf6wy3	74	10	IFN	IFN	NNP
cord-305263-fgwf6wy3	74	11	production	production	NN
cord-305263-fgwf6wy3	74	12	in	in	IN
cord-305263-fgwf6wy3	74	13	response	response	NN
cord-305263-fgwf6wy3	74	14	to	to	IN
cord-305263-fgwf6wy3	74	15	viral	viral	JJ
cord-305263-fgwf6wy3	74	16	infection	infection	NN
cord-305263-fgwf6wy3	74	17	[	[	-LRB-
cord-305263-fgwf6wy3	74	18	23	23	CD
cord-305263-fgwf6wy3	74	19	,	,	,
cord-305263-fgwf6wy3	74	20	24	24	CD
cord-305263-fgwf6wy3	74	21	]	]	-RRB-
cord-305263-fgwf6wy3	74	22	.	.	.
cord-305263-fgwf6wy3	75	1	Specifically	specifically	RB
cord-305263-fgwf6wy3	75	2	,	,	,
cord-305263-fgwf6wy3	75	3	Nsp3	Nsp3	NNP
cord-305263-fgwf6wy3	75	4	inhibits	inhibit	VBZ
cord-305263-fgwf6wy3	75	5	IRF3	IRF3	NNP
cord-305263-fgwf6wy3	75	6	in	in	IN
cord-305263-fgwf6wy3	75	7	human	human	JJ
cord-305263-fgwf6wy3	75	8	bronchial	bronchial	JJ
cord-305263-fgwf6wy3	75	9	epithelial	epithelial	JJ
cord-305263-fgwf6wy3	75	10	cells	cell	NNS
cord-305263-fgwf6wy3	75	11	via	via	IN
cord-305263-fgwf6wy3	75	12	its	-PRON-	PRP$
cord-305263-fgwf6wy3	75	13	papain	papain	NN
cord-305263-fgwf6wy3	75	14	-	-	HYPH
cord-305263-fgwf6wy3	75	15	like	like	JJ
cord-305263-fgwf6wy3	75	16	protease	protease	NN
cord-305263-fgwf6wy3	75	17	(	(	-LRB-
cord-305263-fgwf6wy3	75	18	PLP	PLP	NNP
cord-305263-fgwf6wy3	75	19	)	)	-RRB-
cord-305263-fgwf6wy3	75	20	domain	domain	NN
cord-305263-fgwf6wy3	75	21	,	,	,
cord-305263-fgwf6wy3	75	22	which	which	WDT
cord-305263-fgwf6wy3	75	23	[	[	-LRB-
cord-305263-fgwf6wy3	75	24	4	4	CD
cord-305263-fgwf6wy3	75	25	,	,	,
cord-305263-fgwf6wy3	75	26	76	76	CD
cord-305263-fgwf6wy3	75	27	]	]	-RRB-
cord-305263-fgwf6wy3	75	28	,	,	,
cord-305263-fgwf6wy3	75	29	tripartite	tripartite	JJ
cord-305263-fgwf6wy3	75	30	motif	motif	NN
cord-305263-fgwf6wy3	75	31	-	-	HYPH
cord-305263-fgwf6wy3	75	32	containing	contain	VBG
cord-305263-fgwf6wy3	75	33	protein	protein	NN
cord-305263-fgwf6wy3	75	34	5a	5a	CD
cord-305263-fgwf6wy3	75	35	(	(	-LRB-
cord-305263-fgwf6wy3	75	36	TRIM5a	trim5a	NN
cord-305263-fgwf6wy3	75	37	)	)	-RRB-
cord-305263-fgwf6wy3	75	38	and	and	CC
cord-305263-fgwf6wy3	75	39	TRIM22	TRIM22	NNP
cord-305263-fgwf6wy3	75	40	,	,	,
cord-305263-fgwf6wy3	75	41	which	which	WDT
cord-305263-fgwf6wy3	75	42	are	be	VBP
cord-305263-fgwf6wy3	75	43	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	75	44	factors	factor	NNS
cord-305263-fgwf6wy3	75	45	that	that	WDT
cord-305263-fgwf6wy3	75	46	limit	limit	VBP
cord-305263-fgwf6wy3	75	47	HIV-1	HIV-1	NNP
cord-305263-fgwf6wy3	75	48	infection	infection	NN
cord-305263-fgwf6wy3	75	49	[	[	-LRB-
cord-305263-fgwf6wy3	75	50	77	77	CD
cord-305263-fgwf6wy3	75	51	]	]	-RRB-
cord-305263-fgwf6wy3	75	52	,	,	,
cord-305263-fgwf6wy3	75	53	and	and	CC
cord-305263-fgwf6wy3	75	54	transcription	transcription	NN
cord-305263-fgwf6wy3	75	55	factor	factor	NN
cord-305263-fgwf6wy3	75	56	jun	jun	NNP
cord-305263-fgwf6wy3	75	57	-	-	HYPH
cord-305263-fgwf6wy3	75	58	D	D	NNP
cord-305263-fgwf6wy3	75	59	(	(	-LRB-
cord-305263-fgwf6wy3	75	60	JUND	JUND	NNP
cord-305263-fgwf6wy3	75	61	)	)	-RRB-
cord-305263-fgwf6wy3	75	62	and	and	CC
cord-305263-fgwf6wy3	75	63	claudin	claudin	NNP
cord-305263-fgwf6wy3	75	64	4	4	CD
cord-305263-fgwf6wy3	75	65	(	(	-LRB-
cord-305263-fgwf6wy3	75	66	CLDN4	CLDN4	NNP
cord-305263-fgwf6wy3	75	67	)	)	-RRB-
cord-305263-fgwf6wy3	76	1	[	[	-LRB-
cord-305263-fgwf6wy3	76	2	78	78	CD
cord-305263-fgwf6wy3	76	3	]	]	-RRB-
cord-305263-fgwf6wy3	76	4	.	.	.
cord-305263-fgwf6wy3	77	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	77	2	treatment	treatment	NN
cord-305263-fgwf6wy3	77	3	primes	prime	NNS
cord-305263-fgwf6wy3	77	4	cells	cell	NNS
cord-305263-fgwf6wy3	77	5	for	for	IN
cord-305263-fgwf6wy3	77	6	apoptosis	apoptosis	NN
cord-305263-fgwf6wy3	77	7	by	by	IN
cord-305263-fgwf6wy3	77	8	modulating	modulate	VBG
cord-305263-fgwf6wy3	77	9	the	the	DT
cord-305263-fgwf6wy3	77	10	expression	expression	NN
cord-305263-fgwf6wy3	77	11	of	of	IN
cord-305263-fgwf6wy3	77	12	proteasome	proteasome	NN
cord-305263-fgwf6wy3	77	13	subunits	subunit	NNS
cord-305263-fgwf6wy3	77	14	,	,	,
cord-305263-fgwf6wy3	77	15	major	major	JJ
cord-305263-fgwf6wy3	77	16	histocompatibility	histocompatibility	NN
cord-305263-fgwf6wy3	77	17	complex	complex	NN
cord-305263-fgwf6wy3	77	18	(	(	-LRB-
cord-305263-fgwf6wy3	77	19	MHC	MHC	NNP
cord-305263-fgwf6wy3	77	20	)	)	-RRB-
cord-305263-fgwf6wy3	77	21	class	class	NN
cord-305263-fgwf6wy3	77	22	I	i	NN
cord-305263-fgwf6wy3	77	23	,	,	,
cord-305263-fgwf6wy3	77	24	and	and	CC
cord-305263-fgwf6wy3	77	25	FAS	FAS	NNP
cord-305263-fgwf6wy3	77	26	receptor	receptor	NN
cord-305263-fgwf6wy3	77	27	(	(	-LRB-
cord-305263-fgwf6wy3	77	28	CD95	CD95	NNP
cord-305263-fgwf6wy3	77	29	)	)	-RRB-
cord-305263-fgwf6wy3	77	30	[	[	-LRB-
cord-305263-fgwf6wy3	77	31	79	79	CD
cord-305263-fgwf6wy3	77	32	]	]	-RRB-
cord-305263-fgwf6wy3	77	33	[	[	-LRB-
cord-305263-fgwf6wy3	77	34	80	80	CD
cord-305263-fgwf6wy3	77	35	]	]	-RRB-
cord-305263-fgwf6wy3	77	36	[	[	-LRB-
cord-305263-fgwf6wy3	77	37	81	81	CD
cord-305263-fgwf6wy3	77	38	]	]	-RRB-
cord-305263-fgwf6wy3	77	39	[	[	-LRB-
cord-305263-fgwf6wy3	77	40	82	82	CD
cord-305263-fgwf6wy3	77	41	]	]	-RRB-
cord-305263-fgwf6wy3	77	42	.	.	.
cord-305263-fgwf6wy3	78	1	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	78	2	-	-	:
cord-305263-fgwf6wy3	78	3	a	a	NN
cord-305263-fgwf6wy3	78	4	/	/	SYM
cord-305263-fgwf6wy3	78	5	b	b	NN
cord-305263-fgwf6wy3	78	6	also	also	RB
cord-305263-fgwf6wy3	78	7	contribute	contribute	VB
cord-305263-fgwf6wy3	78	8	to	to	IN
cord-305263-fgwf6wy3	78	9	the	the	DT
cord-305263-fgwf6wy3	78	10	activation	activation	NN
cord-305263-fgwf6wy3	78	11	and	and	CC
cord-305263-fgwf6wy3	78	12	differentiation	differentiation	NN
cord-305263-fgwf6wy3	78	13	of	of	IN
cord-305263-fgwf6wy3	78	14	cells	cell	NNS
cord-305263-fgwf6wy3	78	15	involved	involve	VBN
cord-305263-fgwf6wy3	78	16	in	in	IN
cord-305263-fgwf6wy3	78	17	the	the	DT
cord-305263-fgwf6wy3	78	18	(	(	-LRB-
cord-305263-fgwf6wy3	78	19	b	b	NN
cord-305263-fgwf6wy3	78	20	)	)	-RRB-
cord-305263-fgwf6wy3	78	21	innate	innate	JJ
cord-305263-fgwf6wy3	78	22	and	and	CC
cord-305263-fgwf6wy3	78	23	(	(	-LRB-
cord-305263-fgwf6wy3	78	24	c	c	NN
cord-305263-fgwf6wy3	78	25	)	)	-RRB-
cord-305263-fgwf6wy3	78	26	adaptive	adaptive	JJ
cord-305263-fgwf6wy3	78	27	immune	immune	JJ
cord-305263-fgwf6wy3	78	28	responses	response	NNS
cord-305263-fgwf6wy3	78	29	to	to	IN
cord-305263-fgwf6wy3	78	30	virus	virus	NN
cord-305263-fgwf6wy3	78	31	infection	infection	NN
cord-305263-fgwf6wy3	78	32	.	.	.
cord-305263-fgwf6wy3	79	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	79	2	-	-	HYPH
cord-305263-fgwf6wy3	79	3	a	a	NNP
cord-305263-fgwf6wy3	79	4	/	/	SYM
cord-305263-fgwf6wy3	79	5	b	b	NN
cord-305263-fgwf6wy3	79	6	induces	induce	VBZ
cord-305263-fgwf6wy3	79	7	production	production	NN
cord-305263-fgwf6wy3	79	8	of	of	IN
cord-305263-fgwf6wy3	79	9	interleukin	interleukin	NN
cord-305263-fgwf6wy3	79	10	(	(	-LRB-
cord-305263-fgwf6wy3	79	11	IL)-6	IL)-6	NNP
cord-305263-fgwf6wy3	79	12	,	,	,
cord-305263-fgwf6wy3	79	13	IL-12	IL-12	NNP
cord-305263-fgwf6wy3	79	14	,	,	,
cord-305263-fgwf6wy3	79	15	and	and	CC
cord-305263-fgwf6wy3	79	16	IL-15	IL-15	NNP
cord-305263-fgwf6wy3	79	17	by	by	IN
cord-305263-fgwf6wy3	79	18	DCs	DCs	NNP
cord-305263-fgwf6wy3	79	19	,	,	,
cord-305263-fgwf6wy3	79	20	and	and	CC
cord-305263-fgwf6wy3	79	21	IL-10	IL-10	NNP
cord-305263-fgwf6wy3	79	22	by	by	IN
cord-305263-fgwf6wy3	79	23	macrophages	macrophage	NNS
cord-305263-fgwf6wy3	79	24	to	to	TO
cord-305263-fgwf6wy3	79	25	modulate	modulate	VB
cord-305263-fgwf6wy3	79	26	B	b	NN
cord-305263-fgwf6wy3	79	27	and	and	CC
cord-305263-fgwf6wy3	79	28	T	t	NN
cord-305263-fgwf6wy3	79	29	cell	cell	NN
cord-305263-fgwf6wy3	79	30	differentiation	differentiation	NN
cord-305263-fgwf6wy3	79	31	(	(	-LRB-
cord-305263-fgwf6wy3	79	32	Th1	th1	CD
cord-305263-fgwf6wy3	79	33	polarization	polarization	NN
cord-305263-fgwf6wy3	79	34	)	)	-RRB-
cord-305263-fgwf6wy3	79	35	and	and	CC
cord-305263-fgwf6wy3	79	36	activation	activation	NN
cord-305263-fgwf6wy3	79	37	[	[	-LRB-
cord-305263-fgwf6wy3	79	38	79	79	CD
cord-305263-fgwf6wy3	79	39	]	]	-RRB-
cord-305263-fgwf6wy3	79	40	.	.	.
cord-305263-fgwf6wy3	80	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	80	2	-	-	HYPH
cord-305263-fgwf6wy3	80	3	b	b	NNP
cord-305263-fgwf6wy3	80	4	signaling	signaling	NN
cord-305263-fgwf6wy3	80	5	in	in	IN
cord-305263-fgwf6wy3	80	6	pDCs	pDCs	NNP
cord-305263-fgwf6wy3	80	7	leads	lead	VBZ
cord-305263-fgwf6wy3	80	8	to	to	TO
cord-305263-fgwf6wy3	80	9	altered	alter	VBN
cord-305263-fgwf6wy3	80	10	CD69	CD69	NNP
cord-305263-fgwf6wy3	80	11	and	and	CC
cord-305263-fgwf6wy3	80	12	sphingosine-1-phosphate	sphingosine-1-phosphate	NNP
cord-305263-fgwf6wy3	80	13	4	4	CD
cord-305263-fgwf6wy3	81	1	(	(	-LRB-
cord-305263-fgwf6wy3	81	2	S1P4	S1P4	NNP
cord-305263-fgwf6wy3	81	3	)	)	-RRB-
cord-305263-fgwf6wy3	81	4	receptor	receptor	NN
cord-305263-fgwf6wy3	81	5	expression	expression	NN
cord-305263-fgwf6wy3	81	6	,	,	,
cord-305263-fgwf6wy3	81	7	thereby	thereby	RB
cord-305263-fgwf6wy3	81	8	affecting	affect	VBG
cord-305263-fgwf6wy3	81	9	pDC	pDC	NNP
cord-305263-fgwf6wy3	81	10	retention	retention	NN
cord-305263-fgwf6wy3	81	11	in	in	IN
cord-305263-fgwf6wy3	81	12	lymph	lymph	NN
cord-305263-fgwf6wy3	81	13	nodes	node	NNS
cord-305263-fgwf6wy3	81	14	[	[	-LRB-
cord-305263-fgwf6wy3	81	15	83	83	CD
cord-305263-fgwf6wy3	81	16	]	]	-RRB-
cord-305263-fgwf6wy3	81	17	.	.	.
cord-305263-fgwf6wy3	82	1	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	82	2	-	-	:
cord-305263-fgwf6wy3	82	3	a	a	NN
cord-305263-fgwf6wy3	82	4	/	/	SYM
cord-305263-fgwf6wy3	82	5	b	b	TO
cord-305263-fgwf6wy3	82	6	increase	increase	VB
cord-305263-fgwf6wy3	82	7	MHC	MHC	NNP
cord-305263-fgwf6wy3	82	8	class	class	NN
cord-305263-fgwf6wy3	82	9	II	II	NNP
cord-305263-fgwf6wy3	82	10	,	,	,
cord-305263-fgwf6wy3	82	11	CD40	CD40	NNP
cord-305263-fgwf6wy3	82	12	and	and	CC
cord-305263-fgwf6wy3	82	13	CD86	CD86	NNP
cord-305263-fgwf6wy3	82	14	expression	expression	NN
cord-305263-fgwf6wy3	82	15	on	on	IN
cord-305263-fgwf6wy3	82	16	antigen	antigen	NN
cord-305263-fgwf6wy3	82	17	presenting	present	VBG
cord-305263-fgwf6wy3	82	18	cells	cell	NNS
cord-305263-fgwf6wy3	82	19	.	.	.
cord-305263-fgwf6wy3	83	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	83	2	-	-	HYPH
cord-305263-fgwf6wy3	83	3	a	a	NN
cord-305263-fgwf6wy3	83	4	/	/	SYM
cord-305263-fgwf6wy3	83	5	b	b	NN
cord-305263-fgwf6wy3	83	6	treatment	treatment	NN
cord-305263-fgwf6wy3	83	7	induces	induce	VBZ
cord-305263-fgwf6wy3	83	8	macrophage	macrophage	NN
cord-305263-fgwf6wy3	83	9	and	and	CC
cord-305263-fgwf6wy3	83	10	neutrophil	neutrophil	NN
cord-305263-fgwf6wy3	83	11	phagocytosis	phagocytosis	NN
cord-305263-fgwf6wy3	83	12	[	[	-LRB-
cord-305263-fgwf6wy3	83	13	79	79	CD
cord-305263-fgwf6wy3	83	14	,	,	,
cord-305263-fgwf6wy3	83	15	84	84	CD
cord-305263-fgwf6wy3	83	16	]	]	-RRB-
cord-305263-fgwf6wy3	83	17	.	.	.
cord-305263-fgwf6wy3	84	1	Moreover	moreover	RB
cord-305263-fgwf6wy3	84	2	,	,	,
cord-305263-fgwf6wy3	84	3	IFNs	ifns	NN
cord-305263-fgwf6wy3	84	4	-	-	:
cord-305263-fgwf6wy3	84	5	a	a	NN
cord-305263-fgwf6wy3	84	6	/	/	SYM
cord-305263-fgwf6wy3	84	7	b	b	NN
cord-305263-fgwf6wy3	84	8	promote	promote	VB
cord-305263-fgwf6wy3	84	9	neutrophil	neutrophil	NN
cord-305263-fgwf6wy3	84	10	survival	survival	NN
cord-305263-fgwf6wy3	84	11	by	by	IN
cord-305263-fgwf6wy3	84	12	activating	activate	VBG
cord-305263-fgwf6wy3	84	13	cellular	cellular	JJ
cord-305263-fgwf6wy3	84	14	inhibitor	inhibitor	NN
cord-305263-fgwf6wy3	84	15	of	of	IN
cord-305263-fgwf6wy3	84	16	apoptosis	apoptosis	NN
cord-305263-fgwf6wy3	84	17	2	2	CD
cord-305263-fgwf6wy3	84	18	(	(	-LRB-
cord-305263-fgwf6wy3	84	19	cIAP2	ciap2	NN
cord-305263-fgwf6wy3	84	20	)	)	-RRB-
cord-305263-fgwf6wy3	84	21	[	[	-LRB-
cord-305263-fgwf6wy3	84	22	5	5	CD
cord-305263-fgwf6wy3	84	23	]	]	-RRB-
cord-305263-fgwf6wy3	84	24	.	.	.
cord-305263-fgwf6wy3	85	1	Natural	natural	JJ
cord-305263-fgwf6wy3	85	2	killer	killer	NN
cord-305263-fgwf6wy3	85	3	(	(	-LRB-
cord-305263-fgwf6wy3	85	4	NK	NK	NNP
cord-305263-fgwf6wy3	85	5	)	)	-RRB-
cord-305263-fgwf6wy3	85	6	cells	cell	NNS
cord-305263-fgwf6wy3	85	7	respond	respond	VBP
cord-305263-fgwf6wy3	85	8	to	to	IN
cord-305263-fgwf6wy3	85	9	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	85	10	-	-	:
cord-305263-fgwf6wy3	85	11	a	a	NN
cord-305263-fgwf6wy3	85	12	/	/	SYM
cord-305263-fgwf6wy3	85	13	b	b	NN
cord-305263-fgwf6wy3	85	14	with	with	IN
cord-305263-fgwf6wy3	85	15	increased	increase	VBN
cord-305263-fgwf6wy3	85	16	FAS	fas	NN
cord-305263-fgwf6wy3	85	17	ligand	ligand	NN
cord-305263-fgwf6wy3	85	18	(	(	-LRB-
cord-305263-fgwf6wy3	85	19	FASL	FASL	NNP
cord-305263-fgwf6wy3	85	20	)	)	-RRB-
cord-305263-fgwf6wy3	85	21	and	and	CC
cord-305263-fgwf6wy3	85	22	perforin	perforin	NNP
cord-305263-fgwf6wy3	85	23	expression	expression	NN
cord-305263-fgwf6wy3	85	24	,	,	,
cord-305263-fgwf6wy3	85	25	and	and	CC
cord-305263-fgwf6wy3	85	26	IFN	IFN	NNP
cord-305263-fgwf6wy3	85	27	-	-	HYPH
cord-305263-fgwf6wy3	85	28	g	g	NN
cord-305263-fgwf6wy3	85	29	production	production	NN
cord-305263-fgwf6wy3	85	30	[	[	-LRB-
cord-305263-fgwf6wy3	85	31	85	85	CD
cord-305263-fgwf6wy3	85	32	,	,	,
cord-305263-fgwf6wy3	85	33	86	86	CD
cord-305263-fgwf6wy3	85	34	]	]	-RRB-
cord-305263-fgwf6wy3	85	35	.	.	.
cord-305263-fgwf6wy3	86	1	In	in	IN
cord-305263-fgwf6wy3	86	2	response	response	NN
cord-305263-fgwf6wy3	86	3	to	to	IN
cord-305263-fgwf6wy3	86	4	IFNs	ifns	NN
cord-305263-fgwf6wy3	86	5	-	-	:
cord-305263-fgwf6wy3	86	6	a	a	NN
cord-305263-fgwf6wy3	86	7	/	/	SYM
cord-305263-fgwf6wy3	86	8	b	b	NN
cord-305263-fgwf6wy3	86	9	,	,	,
cord-305263-fgwf6wy3	86	10	B	b	NN
cord-305263-fgwf6wy3	86	11	cells	cell	NNS
cord-305263-fgwf6wy3	86	12	upregulate	upregulate	VBP
cord-305263-fgwf6wy3	86	13	L	l	NN
cord-305263-fgwf6wy3	86	14	-	-	HYPH
cord-305263-fgwf6wy3	86	15	selectin	selectin	NNP
cord-305263-fgwf6wy3	86	16	and	and	CC
cord-305263-fgwf6wy3	86	17	IgG	IgG	NNP
cord-305263-fgwf6wy3	86	18	production	production	NN
cord-305263-fgwf6wy3	86	19	[	[	-LRB-
cord-305263-fgwf6wy3	86	20	9	9	CD
cord-305263-fgwf6wy3	86	21	,	,	,
cord-305263-fgwf6wy3	86	22	79	79	CD
cord-305263-fgwf6wy3	86	23	]	]	-RRB-
cord-305263-fgwf6wy3	86	24	.	.	.
cord-305263-fgwf6wy3	87	1	Trends	trend	NNS
cord-305263-fgwf6wy3	87	2	in	in	IN
cord-305263-fgwf6wy3	87	3	Immunology	Immunology	NNP
cord-305263-fgwf6wy3	87	4	April	April	NNP
cord-305263-fgwf6wy3	87	5	2012	2012	CD
cord-305263-fgwf6wy3	87	6	,	,	,
cord-305263-fgwf6wy3	87	7	Vol	Vol	NNP
cord-305263-fgwf6wy3	87	8	.	.	.
cord-305263-fgwf6wy3	88	1	33	33	CD
cord-305263-fgwf6wy3	88	2	,	,	,
cord-305263-fgwf6wy3	88	3	No	no	NN
cord-305263-fgwf6wy3	88	4	.	.	NN
cord-305263-fgwf6wy3	88	5	4	4	CD
cord-305263-fgwf6wy3	88	6	interacts	interact	VBZ
cord-305263-fgwf6wy3	88	7	with	with	IN
cord-305263-fgwf6wy3	88	8	IRF3	IRF3	NNP
cord-305263-fgwf6wy3	88	9	to	to	TO
cord-305263-fgwf6wy3	88	10	inhibit	inhibit	VB
cord-305263-fgwf6wy3	88	11	IRF3	IRF3	NNP
cord-305263-fgwf6wy3	88	12	phosphorylation	phosphorylation	NN
cord-305263-fgwf6wy3	88	13	and	and	CC
cord-305263-fgwf6wy3	88	14	nuclear	nuclear	JJ
cord-305263-fgwf6wy3	88	15	translocation	translocation	NN
cord-305263-fgwf6wy3	88	16	[	[	-LRB-
cord-305263-fgwf6wy3	88	17	24	24	CD
cord-305263-fgwf6wy3	88	18	]	]	-RRB-
cord-305263-fgwf6wy3	88	19	.	.	.
cord-305263-fgwf6wy3	89	1	In	in	IN
cord-305263-fgwf6wy3	89	2	addition	addition	NN
cord-305263-fgwf6wy3	89	3	to	to	IN
cord-305263-fgwf6wy3	89	4	Nsp1	Nsp1	NNP
cord-305263-fgwf6wy3	89	5	and	and	CC
cord-305263-fgwf6wy3	89	6	Nsp3	Nsp3	NNP
cord-305263-fgwf6wy3	89	7	,	,	,
cord-305263-fgwf6wy3	89	8	the	the	DT
cord-305263-fgwf6wy3	89	9	open	open	JJ
cord-305263-fgwf6wy3	89	10	reading	reading	NN
cord-305263-fgwf6wy3	89	11	frame	frame	NN
cord-305263-fgwf6wy3	89	12	6	6	CD
cord-305263-fgwf6wy3	89	13	(	(	-LRB-
cord-305263-fgwf6wy3	89	14	ORF6	ORF6	NNP
cord-305263-fgwf6wy3	89	15	)	)	-RRB-
cord-305263-fgwf6wy3	89	16	and	and	CC
cord-305263-fgwf6wy3	89	17	matrix	matrix	NN
cord-305263-fgwf6wy3	89	18	(	(	-LRB-
cord-305263-fgwf6wy3	89	19	M	M	NNP
cord-305263-fgwf6wy3	89	20	)	)	-RRB-
cord-305263-fgwf6wy3	89	21	proteins	protein	NNS
cord-305263-fgwf6wy3	89	22	of	of	IN
cord-305263-fgwf6wy3	89	23	the	the	DT
cord-305263-fgwf6wy3	89	24	SARS	SARS	NNP
cord-305263-fgwf6wy3	89	25	-	-	HYPH
cord-305263-fgwf6wy3	89	26	CoV	CoV	NNP
cord-305263-fgwf6wy3	89	27	also	also	RB
cord-305263-fgwf6wy3	89	28	inhibit	inhibit	VBP
cord-305263-fgwf6wy3	89	29	an	an	DT
cord-305263-fgwf6wy3	89	30	IFN	IFN	NNP
cord-305263-fgwf6wy3	89	31	response	response	NN
cord-305263-fgwf6wy3	89	32	[	[	-LRB-
cord-305263-fgwf6wy3	89	33	19	19	CD
cord-305263-fgwf6wy3	89	34	,	,	,
cord-305263-fgwf6wy3	89	35	25	25	CD
cord-305263-fgwf6wy3	89	36	]	]	-RRB-
cord-305263-fgwf6wy3	89	37	.	.	.
cord-305263-fgwf6wy3	90	1	ORF6	ORF6	NNP
cord-305263-fgwf6wy3	90	2	localizes	localize	VBZ
cord-305263-fgwf6wy3	90	3	to	to	IN
cord-305263-fgwf6wy3	90	4	the	the	DT
cord-305263-fgwf6wy3	90	5	host	host	NN
cord-305263-fgwf6wy3	90	6	endoplasmic	endoplasmic	NN
cord-305263-fgwf6wy3	90	7	reticulum	reticulum	NN
cord-305263-fgwf6wy3	90	8	(	(	-LRB-
cord-305263-fgwf6wy3	90	9	ER	ER	NNP
cord-305263-fgwf6wy3	90	10	)	)	-RRB-
cord-305263-fgwf6wy3	90	11	and	and	CC
cord-305263-fgwf6wy3	90	12	blocks	block	VBZ
cord-305263-fgwf6wy3	90	13	the	the	DT
cord-305263-fgwf6wy3	90	14	transcription	transcription	NN
cord-305263-fgwf6wy3	90	15	factor	factor	NN
cord-305263-fgwf6wy3	90	16	function	function	NN
cord-305263-fgwf6wy3	90	17	of	of	IN
cord-305263-fgwf6wy3	90	18	phosphorylated	phosphorylated	JJ
cord-305263-fgwf6wy3	90	19	STAT1	stat1	NN
cord-305263-fgwf6wy3	90	20	,	,	,
cord-305263-fgwf6wy3	90	21	by	by	IN
cord-305263-fgwf6wy3	90	22	binding	bind	VBG
cord-305263-fgwf6wy3	90	23	to	to	IN
cord-305263-fgwf6wy3	90	24	nuclear	nuclear	JJ
cord-305263-fgwf6wy3	90	25	import	import	NN
cord-305263-fgwf6wy3	90	26	factors	factor	NNS
cord-305263-fgwf6wy3	90	27	to	to	TO
cord-305263-fgwf6wy3	90	28	prevent	prevent	VB
cord-305263-fgwf6wy3	90	29	its	-PRON-	PRP$
cord-305263-fgwf6wy3	90	30	translocation	translocation	NN
cord-305263-fgwf6wy3	90	31	to	to	IN
cord-305263-fgwf6wy3	90	32	the	the	DT
cord-305263-fgwf6wy3	90	33	nucleus	nucleus	NN
cord-305263-fgwf6wy3	90	34	[	[	-LRB-
cord-305263-fgwf6wy3	90	35	19	19	CD
cord-305263-fgwf6wy3	90	36	]	]	-RRB-
cord-305263-fgwf6wy3	90	37	.	.	.
cord-305263-fgwf6wy3	91	1	The	the	DT
cord-305263-fgwf6wy3	91	2	M	M	NNP
cord-305263-fgwf6wy3	91	3	protein	protein	NN
cord-305263-fgwf6wy3	91	4	interacts	interact	VBZ
cord-305263-fgwf6wy3	91	5	with	with	IN
cord-305263-fgwf6wy3	91	6	RNA	RNA	NNP
cord-305263-fgwf6wy3	91	7	sensor	sensor	NN
cord-305263-fgwf6wy3	91	8	retinoic	retinoic	JJ
cord-305263-fgwf6wy3	91	9	acid	acid	NN
cord-305263-fgwf6wy3	91	10	-	-	HYPH
cord-305263-fgwf6wy3	91	11	inducible	inducible	JJ
cord-305263-fgwf6wy3	91	12	gene	gene	NN
cord-305263-fgwf6wy3	91	13	1	1	CD
cord-305263-fgwf6wy3	91	14	(	(	-LRB-
cord-305263-fgwf6wy3	91	15	RIG	rig	NN
cord-305263-fgwf6wy3	91	16	-	-	:
cord-305263-fgwf6wy3	91	17	I	I	NNP
cord-305263-fgwf6wy3	91	18	)	)	-RRB-
cord-305263-fgwf6wy3	91	19	,	,	,
cord-305263-fgwf6wy3	91	20	an	an	DT
cord-305263-fgwf6wy3	91	21	RNA	RNA	NNP
cord-305263-fgwf6wy3	91	22	helicase	helicase	NN
cord-305263-fgwf6wy3	91	23	and	and	CC
cord-305263-fgwf6wy3	91	24	key	key	NN
cord-305263-fgwf6wy3	91	25	intracellular	intracellular	JJ
cord-305263-fgwf6wy3	91	26	PRR	PRR	NNP
cord-305263-fgwf6wy3	91	27	associated	associate	VBN
cord-305263-fgwf6wy3	91	28	with	with	IN
cord-305263-fgwf6wy3	91	29	induction	induction	NN
cord-305263-fgwf6wy3	91	30	of	of	IN
cord-305263-fgwf6wy3	91	31	IRF	IRF	NNP
cord-305263-fgwf6wy3	91	32	-	-	HYPH
cord-305263-fgwf6wy3	91	33	dependent	dependent	JJ
cord-305263-fgwf6wy3	91	34	IFN	IFN	NNP
cord-305263-fgwf6wy3	91	35	production	production	NN
cord-305263-fgwf6wy3	91	36	following	follow	VBG
cord-305263-fgwf6wy3	91	37	detection	detection	NN
cord-305263-fgwf6wy3	91	38	of	of	IN
cord-305263-fgwf6wy3	91	39	viral	viral	JJ
cord-305263-fgwf6wy3	91	40	RNAs	rna	NNS
cord-305263-fgwf6wy3	91	41	.	.	.
cord-305263-fgwf6wy3	92	1	The	the	DT
cord-305263-fgwf6wy3	92	2	M	M	NNP
cord-305263-fgwf6wy3	92	3	protein	protein	NN
cord-305263-fgwf6wy3	92	4	also	also	RB
cord-305263-fgwf6wy3	92	5	interacts	interact	VBZ
cord-305263-fgwf6wy3	92	6	with	with	IN
cord-305263-fgwf6wy3	92	7	the	the	DT
cord-305263-fgwf6wy3	92	8	signaling	signal	VBG
cord-305263-fgwf6wy3	92	9	effectors	effector	NNS
cord-305263-fgwf6wy3	92	10	serine	serine	NN
cord-305263-fgwf6wy3	92	11	/	/	SYM
cord-305263-fgwf6wy3	92	12	threonine	threonine	NN
cord-305263-fgwf6wy3	92	13	-	-	HYPH
cord-305263-fgwf6wy3	92	14	protein	protein	NN
cord-305263-fgwf6wy3	92	15	kinase	kinase	NN
cord-305263-fgwf6wy3	92	16	1	1	CD
cord-305263-fgwf6wy3	92	17	(	(	-LRB-
cord-305263-fgwf6wy3	92	18	TBK1	TBK1	NNP
cord-305263-fgwf6wy3	92	19	)	)	-RRB-
cord-305263-fgwf6wy3	92	20	,	,	,
cord-305263-fgwf6wy3	92	21	inhibitor	inhibitor	NN
cord-305263-fgwf6wy3	92	22	of	of	IN
cord-305263-fgwf6wy3	92	23	nuclear	nuclear	JJ
cord-305263-fgwf6wy3	92	24	factor	factor	NN
cord-305263-fgwf6wy3	92	25	-	-	HYPH
cord-305263-fgwf6wy3	92	26	kB	kB	NNP
cord-305263-fgwf6wy3	92	27	kinase	kinase	NN
cord-305263-fgwf6wy3	92	28	subunit	subunit	NN
cord-305263-fgwf6wy3	92	29	e	e	NN
cord-305263-fgwf6wy3	92	30	(	(	-LRB-
cord-305263-fgwf6wy3	92	31	IKKe	IKKe	NNP
cord-305263-fgwf6wy3	92	32	)	)	-RRB-
cord-305263-fgwf6wy3	92	33	,	,	,
cord-305263-fgwf6wy3	92	34	and	and	CC
cord-305263-fgwf6wy3	92	35	tumor	tumor	NN
cord-305263-fgwf6wy3	92	36	necrosis	necrosis	NN
cord-305263-fgwf6wy3	92	37	factor	factor	NN
cord-305263-fgwf6wy3	92	38	(	(	-LRB-
cord-305263-fgwf6wy3	92	39	TNF)-associated	tnf)-associated	JJ
cord-305263-fgwf6wy3	92	40	factor	factor	NN
cord-305263-fgwf6wy3	92	41	3	3	CD
cord-305263-fgwf6wy3	92	42	(	(	-LRB-
cord-305263-fgwf6wy3	92	43	TRAF3	TRAF3	NNP
cord-305263-fgwf6wy3	92	44	)	)	-RRB-
cord-305263-fgwf6wy3	92	45	,	,	,
cord-305263-fgwf6wy3	92	46	again	again	RB
cord-305263-fgwf6wy3	92	47	associated	associate	VBN
cord-305263-fgwf6wy3	92	48	with	with	IN
cord-305263-fgwf6wy3	92	49	IFN	IFN	NNP
cord-305263-fgwf6wy3	92	50	gene	gene	NN
cord-305263-fgwf6wy3	92	51	induction	induction	NN
cord-305263-fgwf6wy3	92	52	[	[	-LRB-
cord-305263-fgwf6wy3	92	53	25	25	CD
cord-305263-fgwf6wy3	92	54	]	]	-RRB-
cord-305263-fgwf6wy3	92	55	.	.	.
cord-305263-fgwf6wy3	93	1	Thus	thus	RB
cord-305263-fgwf6wy3	93	2	,	,	,
cord-305263-fgwf6wy3	93	3	there	there	EX
cord-305263-fgwf6wy3	93	4	are	be	VBP
cord-305263-fgwf6wy3	93	5	multiple	multiple	JJ
cord-305263-fgwf6wy3	93	6	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	93	7	by	by	IN
cord-305263-fgwf6wy3	93	8	which	which	WDT
cord-305263-fgwf6wy3	93	9	SARS	SARS	NNP
cord-305263-fgwf6wy3	93	10	-	-	HYPH
cord-305263-fgwf6wy3	93	11	CoV	CoV	NNP
cord-305263-fgwf6wy3	93	12	might	may	MD
cord-305263-fgwf6wy3	93	13	inhibit	inhibit	VB
cord-305263-fgwf6wy3	93	14	the	the	DT
cord-305263-fgwf6wy3	93	15	host	host	NN
cord-305263-fgwf6wy3	93	16	IFN	IFN	NNP
cord-305263-fgwf6wy3	93	17	response	response	NN
cord-305263-fgwf6wy3	93	18	.	.	.
cord-305263-fgwf6wy3	94	1	The	the	DT
cord-305263-fgwf6wy3	94	2	implications	implication	NNS
cord-305263-fgwf6wy3	94	3	are	be	VBP
cord-305263-fgwf6wy3	94	4	that	that	IN
cord-305263-fgwf6wy3	94	5	an	an	DT
cord-305263-fgwf6wy3	94	6	IFN	IFN	NNP
cord-305263-fgwf6wy3	94	7	response	response	NN
cord-305263-fgwf6wy3	94	8	to	to	IN
cord-305263-fgwf6wy3	94	9	SARS	SARS	NNP
cord-305263-fgwf6wy3	94	10	-	-	HYPH
cord-305263-fgwf6wy3	94	11	CoV	CoV	NNP
cord-305263-fgwf6wy3	94	12	infection	infection	NN
cord-305263-fgwf6wy3	94	13	must	must	MD
cord-305263-fgwf6wy3	94	14	be	be	VB
cord-305263-fgwf6wy3	94	15	dramatically	dramatically	RB
cord-305263-fgwf6wy3	94	16	limited	limit	VBN
cord-305263-fgwf6wy3	94	17	for	for	IN
cord-305263-fgwf6wy3	94	18	virus	virus	NN
cord-305263-fgwf6wy3	94	19	replication	replication	NN
cord-305263-fgwf6wy3	94	20	to	to	TO
cord-305263-fgwf6wy3	94	21	proceed	proceed	VB
cord-305263-fgwf6wy3	94	22	,	,	,
cord-305263-fgwf6wy3	94	23	suggesting	suggest	VBG
cord-305263-fgwf6wy3	94	24	that	that	IN
cord-305263-fgwf6wy3	94	25	the	the	DT
cord-305263-fgwf6wy3	94	26	dominant	dominant	JJ
cord-305263-fgwf6wy3	94	27	immune	immune	JJ
cord-305263-fgwf6wy3	94	28	response	response	NN
cord-305263-fgwf6wy3	94	29	is	be	VBZ
cord-305263-fgwf6wy3	94	30	the	the	DT
cord-305263-fgwf6wy3	94	31	IFN	IFN	NNP
cord-305263-fgwf6wy3	94	32	response	response	NN
cord-305263-fgwf6wy3	94	33	.	.	.
cord-305263-fgwf6wy3	95	1	Different	different	JJ
cord-305263-fgwf6wy3	95	2	recombinant	recombinant	JJ
cord-305263-fgwf6wy3	95	3	IFN	IFN	NNP
cord-305263-fgwf6wy3	95	4	-	-	:
cord-305263-fgwf6wy3	95	5	as	as	IN
cord-305263-fgwf6wy3	95	6	and	and	CC
cord-305263-fgwf6wy3	95	7	IFN	IFN	NNP
cord-305263-fgwf6wy3	95	8	-	-	HYPH
cord-305263-fgwf6wy3	95	9	b	b	NNP
cord-305263-fgwf6wy3	95	10	are	be	VBP
cord-305263-fgwf6wy3	95	11	now	now	RB
cord-305263-fgwf6wy3	95	12	approved	approve	VBN
cord-305263-fgwf6wy3	95	13	for	for	IN
cord-305263-fgwf6wy3	95	14	various	various	JJ
cord-305263-fgwf6wy3	95	15	clinical	clinical	JJ
cord-305263-fgwf6wy3	95	16	indications	indication	NNS
cord-305263-fgwf6wy3	95	17	,	,	,
cord-305263-fgwf6wy3	95	18	including	include	VBG
cord-305263-fgwf6wy3	95	19	the	the	DT
cord-305263-fgwf6wy3	95	20	treatment	treatment	NN
cord-305263-fgwf6wy3	95	21	of	of	IN
cord-305263-fgwf6wy3	95	22	chronic	chronic	JJ
cord-305263-fgwf6wy3	95	23	HCV	HCV	NNP
cord-305263-fgwf6wy3	95	24	infections	infection	NNS
cord-305263-fgwf6wy3	95	25	[	[	-LRB-
cord-305263-fgwf6wy3	95	26	26	26	CD
cord-305263-fgwf6wy3	95	27	,	,	,
cord-305263-fgwf6wy3	95	28	27	27	CD
cord-305263-fgwf6wy3	95	29	]	]	-RRB-
cord-305263-fgwf6wy3	95	30	.	.	.
cord-305263-fgwf6wy3	96	1	Through	through	IN
cord-305263-fgwf6wy3	96	2	a	a	DT
cord-305263-fgwf6wy3	96	3	comprehensive	comprehensive	JJ
cord-305263-fgwf6wy3	96	4	analysis	analysis	NN
cord-305263-fgwf6wy3	96	5	of	of	IN
cord-305263-fgwf6wy3	96	6	how	how	WRB
cord-305263-fgwf6wy3	96	7	structural	structural	JJ
cord-305263-fgwf6wy3	96	8	features	feature	NNS
cord-305263-fgwf6wy3	96	9	in	in	IN
cord-305263-fgwf6wy3	96	10	the	the	DT
cord-305263-fgwf6wy3	96	11	IFN	IFN	NNP
cord-305263-fgwf6wy3	96	12	-	-	HYPH
cord-305263-fgwf6wy3	96	13	a	a	NNP
cord-305263-fgwf6wy3	96	14	/	/	SYM
cord-305263-fgwf6wy3	96	15	b	b	IN
cord-305263-fgwf6wy3	96	16	moleculescrucial	moleculescrucial	JJ
cord-305263-fgwf6wy3	96	17	clusters	cluster	NNS
cord-305263-fgwf6wy3	96	18	of	of	IN
cord-305263-fgwf6wy3	96	19	amino	amino	NNS
cord-305263-fgwf6wy3	96	20	acidsaffect	acidsaffect	VBP
cord-305263-fgwf6wy3	96	21	the	the	DT
cord-305263-fgwf6wy3	96	22	sensitivity	sensitivity	NN
cord-305263-fgwf6wy3	96	23	of	of	IN
cord-305263-fgwf6wy3	96	24	target	target	NN
cord-305263-fgwf6wy3	96	25	cells	cell	NNS
cord-305263-fgwf6wy3	96	26	to	to	IN
cord-305263-fgwf6wy3	96	27	IFN	IFN	NNP
cord-305263-fgwf6wy3	96	28	-	-	HYPH
cord-305263-fgwf6wy3	96	29	induced	induce	VBN
cord-305263-fgwf6wy3	96	30	biological	biological	JJ
cord-305263-fgwf6wy3	96	31	responses	response	NNS
cord-305263-fgwf6wy3	96	32	,	,	,
cord-305263-fgwf6wy3	96	33	specific	specific	JJ
cord-305263-fgwf6wy3	96	34	epitopes	epitope	NNS
cord-305263-fgwf6wy3	96	35	on	on	IN
cord-305263-fgwf6wy3	96	36	the	the	DT
cord-305263-fgwf6wy3	96	37	exposed	expose	VBN
cord-305263-fgwf6wy3	96	38	surface	surface	NN
cord-305263-fgwf6wy3	96	39	of	of	IN
cord-305263-fgwf6wy3	96	40	the	the	DT
cord-305263-fgwf6wy3	96	41	IFN	IFN	NNP
cord-305263-fgwf6wy3	96	42	molecule	molecule	NN
cord-305263-fgwf6wy3	96	43	have	have	VBP
cord-305263-fgwf6wy3	96	44	been	be	VBN
cord-305263-fgwf6wy3	96	45	identified	identify	VBN
cord-305263-fgwf6wy3	96	46	that	that	WDT
cord-305263-fgwf6wy3	96	47	are	be	VBP
cord-305263-fgwf6wy3	96	48	associated	associate	VBN
cord-305263-fgwf6wy3	96	49	with	with	IN
cord-305263-fgwf6wy3	96	50	receptor	receptor	NN
cord-305263-fgwf6wy3	96	51	recognition	recognition	NN
cord-305263-fgwf6wy3	96	52	[	[	-LRB-
cord-305263-fgwf6wy3	96	53	28	28	CD
cord-305263-fgwf6wy3	96	54	]	]	-RRB-
cord-305263-fgwf6wy3	96	55	[	[	-LRB-
cord-305263-fgwf6wy3	96	56	29	29	CD
cord-305263-fgwf6wy3	96	57	]	]	-RRB-
cord-305263-fgwf6wy3	96	58	[	[	-LRB-
cord-305263-fgwf6wy3	96	59	30	30	CD
cord-305263-fgwf6wy3	96	60	]	]	-RRB-
cord-305263-fgwf6wy3	96	61	[	[	-LRB-
cord-305263-fgwf6wy3	96	62	31	31	CD
cord-305263-fgwf6wy3	96	63	]	]	-RRB-
cord-305263-fgwf6wy3	96	64	[	[	-LRB-
cord-305263-fgwf6wy3	96	65	32	32	CD
cord-305263-fgwf6wy3	96	66	]	]	-RRB-
cord-305263-fgwf6wy3	96	67	[	[	-LRB-
cord-305263-fgwf6wy3	96	68	33	33	CD
cord-305263-fgwf6wy3	96	69	]	]	-RRB-
cord-305263-fgwf6wy3	96	70	[	[	-LRB-
cord-305263-fgwf6wy3	96	71	34	34	CD
cord-305263-fgwf6wy3	96	72	]	]	-RRB-
cord-305263-fgwf6wy3	96	73	[	[	-LRB-
cord-305263-fgwf6wy3	96	74	35	35	CD
cord-305263-fgwf6wy3	96	75	]	]	-RRB-
cord-305263-fgwf6wy3	96	76	[	[	-LRB-
cord-305263-fgwf6wy3	96	77	36	36	CD
cord-305263-fgwf6wy3	96	78	]	]	-RRB-
cord-305263-fgwf6wy3	96	79	[	[	-LRB-
cord-305263-fgwf6wy3	96	80	37	37	CD
cord-305263-fgwf6wy3	96	81	]	]	-RRB-
cord-305263-fgwf6wy3	96	82	[	[	-LRB-
cord-305263-fgwf6wy3	96	83	38	38	CD
cord-305263-fgwf6wy3	96	84	]	]	-RRB-
cord-305263-fgwf6wy3	96	85	[	[	-LRB-
cord-305263-fgwf6wy3	96	86	39	39	CD
cord-305263-fgwf6wy3	96	87	]	]	-RRB-
cord-305263-fgwf6wy3	96	88	.	.	.
cord-305263-fgwf6wy3	97	1	Accumulating	accumulate	VBG
cord-305263-fgwf6wy3	97	2	evidence	evidence	NN
cord-305263-fgwf6wy3	97	3	suggests	suggest	VBZ
cord-305263-fgwf6wy3	97	4	that	that	IN
cord-305263-fgwf6wy3	97	5	the	the	DT
cord-305263-fgwf6wy3	97	6	affinity	affinity	NN
cord-305263-fgwf6wy3	97	7	of	of	IN
cord-305263-fgwf6wy3	97	8	a	a	DT
cord-305263-fgwf6wy3	97	9	particular	particular	JJ
cord-305263-fgwf6wy3	97	10	IFN	IFN	NNP
cord-305263-fgwf6wy3	97	11	-	-	HYPH
cord-305263-fgwf6wy3	97	12	a	a	NN
cord-305263-fgwf6wy3	97	13	/	/	SYM
cord-305263-fgwf6wy3	97	14	b	b	NN
cord-305263-fgwf6wy3	97	15	subtype	subtype	NN
cord-305263-fgwf6wy3	97	16	for	for	IN
cord-305263-fgwf6wy3	97	17	IFNAR	IFNAR	NNP
cord-305263-fgwf6wy3	97	18	determines	determine	VBZ
cord-305263-fgwf6wy3	97	19	the	the	DT
cord-305263-fgwf6wy3	97	20	biopotency	biopotency	NN
cord-305263-fgwf6wy3	97	21	of	of	IN
cord-305263-fgwf6wy3	97	22	the	the	DT
cord-305263-fgwf6wy3	97	23	IFN	IFN	NNP
cord-305263-fgwf6wy3	97	24	,	,	,
cord-305263-fgwf6wy3	97	25	specifically	specifically	RB
cord-305263-fgwf6wy3	97	26	in	in	IN
cord-305263-fgwf6wy3	97	27	the	the	DT
cord-305263-fgwf6wy3	97	28	context	context	NN
cord-305263-fgwf6wy3	97	29	of	of	IN
cord-305263-fgwf6wy3	97	30	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	97	31	and	and	CC
cord-305263-fgwf6wy3	97	32	antiproliferative	antiproliferative	JJ
cord-305263-fgwf6wy3	97	33	responses	response	NNS
cord-305263-fgwf6wy3	97	34	[	[	-LRB-
cord-305263-fgwf6wy3	97	35	28	28	CD
cord-305263-fgwf6wy3	97	36	,	,	,
cord-305263-fgwf6wy3	97	37	39	39	CD
cord-305263-fgwf6wy3	97	38	]	]	-RRB-
cord-305263-fgwf6wy3	97	39	.	.	.
cord-305263-fgwf6wy3	98	1	A	a	DT
cord-305263-fgwf6wy3	98	2	direct	direct	JJ
cord-305263-fgwf6wy3	98	3	consequence	consequence	NN
cord-305263-fgwf6wy3	98	4	of	of	IN
cord-305263-fgwf6wy3	98	5	this	this	DT
cord-305263-fgwf6wy3	98	6	was	be	VBD
cord-305263-fgwf6wy3	98	7	the	the	DT
cord-305263-fgwf6wy3	98	8	design	design	NN
cord-305263-fgwf6wy3	98	9	and	and	CC
cord-305263-fgwf6wy3	98	10	development	development	NN
cord-305263-fgwf6wy3	98	11	of	of	IN
cord-305263-fgwf6wy3	98	12	a	a	DT
cord-305263-fgwf6wy3	98	13	synthetic	synthetic	JJ
cord-305263-fgwf6wy3	98	14	IFN	IFN	NNP
cord-305263-fgwf6wy3	98	15	-	-	HYPH
cord-305263-fgwf6wy3	98	16	a	a	NN
cord-305263-fgwf6wy3	99	1	,	,	,
cord-305263-fgwf6wy3	99	2	IFN	IFN	NNP
cord-305263-fgwf6wy3	99	3	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	99	4	,	,	,
cord-305263-fgwf6wy3	99	5	that	that	WDT
cord-305263-fgwf6wy3	99	6	exhibits	exhibit	VBZ
cord-305263-fgwf6wy3	99	7	optimized	optimize	VBN
cord-305263-fgwf6wy3	99	8	affinity	affinity	NN
cord-305263-fgwf6wy3	99	9	for	for	IN
cord-305263-fgwf6wy3	99	10	IFNAR	IFNAR	NNP
cord-305263-fgwf6wy3	99	11	[	[	-LRB-
cord-305263-fgwf6wy3	99	12	40	40	CD
cord-305263-fgwf6wy3	99	13	]	]	-RRB-
cord-305263-fgwf6wy3	99	14	[	[	-LRB-
cord-305263-fgwf6wy3	99	15	41	41	CD
cord-305263-fgwf6wy3	99	16	]	]	-RRB-
cord-305263-fgwf6wy3	99	17	[	[	-LRB-
cord-305263-fgwf6wy3	99	18	42	42	CD
cord-305263-fgwf6wy3	99	19	]	]	-RRB-
cord-305263-fgwf6wy3	99	20	[	[	-LRB-
cord-305263-fgwf6wy3	99	21	43	43	CD
cord-305263-fgwf6wy3	99	22	]	]	-RRB-
cord-305263-fgwf6wy3	99	23	.	.	.
cord-305263-fgwf6wy3	100	1	Initially	initially	RB
cord-305263-fgwf6wy3	100	2	,	,	,
cord-305263-fgwf6wy3	100	3	treatment	treatment	NN
cord-305263-fgwf6wy3	100	4	for	for	IN
cord-305263-fgwf6wy3	100	5	SARS	SARS	NNP
cord-305263-fgwf6wy3	100	6	-	-	HYPH
cord-305263-fgwf6wy3	100	7	CoV	CoV	NNP
cord-305263-fgwf6wy3	100	8	infection	infection	NN
cord-305263-fgwf6wy3	100	9	focused	focus	VBD
cord-305263-fgwf6wy3	100	10	on	on	IN
cord-305263-fgwf6wy3	100	11	the	the	DT
cord-305263-fgwf6wy3	100	12	use	use	NN
cord-305263-fgwf6wy3	100	13	of	of	IN
cord-305263-fgwf6wy3	100	14	a	a	DT
cord-305263-fgwf6wy3	100	15	DAA	DAA	NNP
cord-305263-fgwf6wy3	100	16	,	,	,
cord-305263-fgwf6wy3	100	17	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	100	18	,	,	,
cord-305263-fgwf6wy3	100	19	in	in	IN
cord-305263-fgwf6wy3	100	20	combination	combination	NN
cord-305263-fgwf6wy3	100	21	with	with	IN
cord-305263-fgwf6wy3	100	22	corticosteroid	corticosteroid	NN
cord-305263-fgwf6wy3	100	23	therapy	therapy	NN
cord-305263-fgwf6wy3	100	24	[	[	-LRB-
cord-305263-fgwf6wy3	100	25	44	44	CD
cord-305263-fgwf6wy3	100	26	,	,	,
cord-305263-fgwf6wy3	100	27	45	45	CD
cord-305263-fgwf6wy3	100	28	]	]	-RRB-
cord-305263-fgwf6wy3	100	29	.	.	.
cord-305263-fgwf6wy3	101	1	However	however	RB
cord-305263-fgwf6wy3	101	2	,	,	,
cord-305263-fgwf6wy3	101	3	in	in	IN
cord-305263-fgwf6wy3	101	4	a	a	DT
cord-305263-fgwf6wy3	101	5	pilot	pilot	NN
cord-305263-fgwf6wy3	101	6	clinical	clinical	JJ
cord-305263-fgwf6wy3	101	7	study	study	NN
cord-305263-fgwf6wy3	101	8	,	,	,
cord-305263-fgwf6wy3	101	9	the	the	DT
cord-305263-fgwf6wy3	101	10	therapeutic	therapeutic	JJ
cord-305263-fgwf6wy3	101	11	potential	potential	NN
cord-305263-fgwf6wy3	101	12	of	of	IN
cord-305263-fgwf6wy3	101	13	IFN	IFN	NNP
cord-305263-fgwf6wy3	101	14	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	101	15	was	be	VBD
cord-305263-fgwf6wy3	101	16	evaluated	evaluate	VBN
cord-305263-fgwf6wy3	101	17	in	in	IN
cord-305263-fgwf6wy3	101	18	individuals	individual	NNS
cord-305263-fgwf6wy3	101	19	infected	infect	VBN
cord-305263-fgwf6wy3	101	20	with	with	IN
cord-305263-fgwf6wy3	101	21	SARS	SARS	NNP
cord-305263-fgwf6wy3	101	22	-	-	HYPH
cord-305263-fgwf6wy3	101	23	CoV	CoV	NNP
cord-305263-fgwf6wy3	101	24	and	and	CC
cord-305263-fgwf6wy3	101	25	hospitalized	hospitalize	VBN
cord-305263-fgwf6wy3	101	26	in	in	IN
cord-305263-fgwf6wy3	101	27	Toronto	Toronto	NNP
cord-305263-fgwf6wy3	101	28	,	,	,
cord-305263-fgwf6wy3	101	29	Canada	Canada	NNP
cord-305263-fgwf6wy3	101	30	[	[	-LRB-
cord-305263-fgwf6wy3	101	31	46	46	CD
cord-305263-fgwf6wy3	101	32	]	]	-RRB-
cord-305263-fgwf6wy3	101	33	.	.	.
cord-305263-fgwf6wy3	102	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	102	2	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	102	3	treatment	treatment	NN
cord-305263-fgwf6wy3	102	4	together	together	RB
cord-305263-fgwf6wy3	102	5	with	with	IN
cord-305263-fgwf6wy3	102	6	corticosteroids	corticosteroid	NNS
cord-305263-fgwf6wy3	102	7	is	be	VBZ
cord-305263-fgwf6wy3	102	8	associated	associate	VBN
cord-305263-fgwf6wy3	102	9	with	with	IN
cord-305263-fgwf6wy3	102	10	reduced	reduce	VBN
cord-305263-fgwf6wy3	102	11	disease	disease	NN
cord-305263-fgwf6wy3	102	12	-	-	HYPH
cord-305263-fgwf6wy3	102	13	associated	associate	VBN
cord-305263-fgwf6wy3	102	14	impaired	impair	VBN
cord-305263-fgwf6wy3	102	15	oxygen	oxygen	NN
cord-305263-fgwf6wy3	102	16	saturation	saturation	NN
cord-305263-fgwf6wy3	102	17	,	,	,
cord-305263-fgwf6wy3	102	18	more	more	RBR
cord-305263-fgwf6wy3	102	19	rapid	rapid	JJ
cord-305263-fgwf6wy3	102	20	resolution	resolution	NN
cord-305263-fgwf6wy3	102	21	of	of	IN
cord-305263-fgwf6wy3	102	22	radiographic	radiographic	JJ
cord-305263-fgwf6wy3	102	23	lung	lung	NN
cord-305263-fgwf6wy3	102	24	abnormalities	abnormality	NNS
cord-305263-fgwf6wy3	102	25	and	and	CC
cord-305263-fgwf6wy3	102	26	lower	low	JJR
cord-305263-fgwf6wy3	102	27	levels	level	NNS
cord-305263-fgwf6wy3	102	28	of	of	IN
cord-305263-fgwf6wy3	102	29	disease	disease	NN
cord-305263-fgwf6wy3	102	30	-	-	HYPH
cord-305263-fgwf6wy3	102	31	associated	associate	VBN
cord-305263-fgwf6wy3	102	32	creatine	creatine	NN
cord-305263-fgwf6wy3	102	33	kinase	kinase	NN
cord-305263-fgwf6wy3	102	34	.	.	.
cord-305263-fgwf6wy3	103	1	In	in	IN
cord-305263-fgwf6wy3	103	2	vitro	vitro	FW
cord-305263-fgwf6wy3	103	3	studies	study	NNS
cord-305263-fgwf6wy3	103	4	to	to	TO
cord-305263-fgwf6wy3	103	5	examine	examine	VB
cord-305263-fgwf6wy3	103	6	the	the	DT
cord-305263-fgwf6wy3	103	7	mechanism	mechanism	NN
cord-305263-fgwf6wy3	103	8	of	of	IN
cord-305263-fgwf6wy3	103	9	action	action	NN
cord-305263-fgwf6wy3	103	10	of	of	IN
cord-305263-fgwf6wy3	103	11	IFN	IFN	NNP
cord-305263-fgwf6wy3	103	12	against	against	IN
cord-305263-fgwf6wy3	103	13	the	the	DT
cord-305263-fgwf6wy3	103	14	SARS	SARS	NNP
cord-305263-fgwf6wy3	103	15	-	-	HYPH
cord-305263-fgwf6wy3	103	16	CoV	CoV	NNP
cord-305263-fgwf6wy3	103	17	have	have	VBP
cord-305263-fgwf6wy3	103	18	revealed	reveal	VBN
cord-305263-fgwf6wy3	103	19	that	that	IN
cord-305263-fgwf6wy3	103	20	IFN	IFN	NNP
cord-305263-fgwf6wy3	103	21	-	-	HYPH
cord-305263-fgwf6wy3	103	22	inducible	inducible	JJ
cord-305263-fgwf6wy3	103	23	Janus	Janus	NNP
cord-305263-fgwf6wy3	103	24	kinase	kinase	NN
cord-305263-fgwf6wy3	103	25	1	1	CD
cord-305263-fgwf6wy3	103	26	(	(	-LRB-
cord-305263-fgwf6wy3	103	27	JAK1	JAK1	NNP
cord-305263-fgwf6wy3	103	28	)	)	-RRB-
cord-305263-fgwf6wy3	103	29	,	,	,
cord-305263-fgwf6wy3	103	30	protein	protein	NN
cord-305263-fgwf6wy3	103	31	kinase	kinase	NN
cord-305263-fgwf6wy3	103	32	C	C	NNP
cord-305263-fgwf6wy3	103	33	(	(	-LRB-
cord-305263-fgwf6wy3	103	34	PKC)-d	PKC)-d	NNP
cord-305263-fgwf6wy3	103	35	and	and	CC
cord-305263-fgwf6wy3	103	36	p38	p38	CD
cord-305263-fgwf6wy3	103	37	mitogen	mitogen	NN
cord-305263-fgwf6wy3	103	38	-	-	HYPH
cord-305263-fgwf6wy3	103	39	activated	activate	VBN
cord-305263-fgwf6wy3	103	40	protein	protein	NN
cord-305263-fgwf6wy3	103	41	kinase	kinase	NN
cord-305263-fgwf6wy3	103	42	(	(	-LRB-
cord-305263-fgwf6wy3	103	43	MAPK	MAPK	NNP
cord-305263-fgwf6wy3	103	44	)	)	-RRB-
cord-305263-fgwf6wy3	103	45	activation	activation	NN
cord-305263-fgwf6wy3	103	46	mediate	mediate	VBP
cord-305263-fgwf6wy3	103	47	IFN	IFN	NNP
cord-305263-fgwf6wy3	103	48	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	103	49	protection	protection	NN
cord-305263-fgwf6wy3	103	50	.	.	.
cord-305263-fgwf6wy3	104	1	Target	target	NN
cord-305263-fgwf6wy3	104	2	genes	gene	NNS
cord-305263-fgwf6wy3	104	3	downstream	downstream	RB
cord-305263-fgwf6wy3	104	4	of	of	IN
cord-305263-fgwf6wy3	104	5	activation	activation	NN
cord-305263-fgwf6wy3	104	6	of	of	IN
cord-305263-fgwf6wy3	104	7	these	these	DT
cord-305263-fgwf6wy3	104	8	kinases	kinase	NNS
cord-305263-fgwf6wy3	104	9	are	be	VBP
cord-305263-fgwf6wy3	104	10	differentially	differentially	RB
cord-305263-fgwf6wy3	104	11	expressed	express	VBN
cord-305263-fgwf6wy3	104	12	in	in	IN
cord-305263-fgwf6wy3	104	13	the	the	DT
cord-305263-fgwf6wy3	104	14	peripheral	peripheral	JJ
cord-305263-fgwf6wy3	104	15	blood	blood	NN
cord-305263-fgwf6wy3	104	16	cells	cell	NNS
cord-305263-fgwf6wy3	104	17	of	of	IN
cord-305263-fgwf6wy3	104	18	SARS	SARS	NNP
cord-305263-fgwf6wy3	104	19	patients	patient	NNS
cord-305263-fgwf6wy3	105	1	treated	treat	VBN
cord-305263-fgwf6wy3	105	2	with	with	IN
cord-305263-fgwf6wy3	105	3	IFN	IFN	NNP
cord-305263-fgwf6wy3	105	4	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	105	5	compared	compare	VBD
cord-305263-fgwf6wy3	105	6	with	with	IN
cord-305263-fgwf6wy3	105	7	patients	patient	NNS
cord-305263-fgwf6wy3	105	8	not	not	RB
cord-305263-fgwf6wy3	105	9	treated	treat	VBN
cord-305263-fgwf6wy3	105	10	with	with	IN
cord-305263-fgwf6wy3	105	11	IFN	IFN	NNP
cord-305263-fgwf6wy3	105	12	,	,	,
cord-305263-fgwf6wy3	105	13	and	and	CC
cord-305263-fgwf6wy3	105	14	functionally	functionally	RB
cord-305263-fgwf6wy3	105	15	these	these	DT
cord-305263-fgwf6wy3	105	16	genes	gene	NNS
cord-305263-fgwf6wy3	105	17	are	be	VBP
cord-305263-fgwf6wy3	105	18	associated	associate	VBN
cord-305263-fgwf6wy3	105	19	with	with	IN
cord-305263-fgwf6wy3	105	20	antimicrobial	antimicrobial	JJ
cord-305263-fgwf6wy3	105	21	activity	activity	NN
cord-305263-fgwf6wy3	105	22	[	[	-LRB-
cord-305263-fgwf6wy3	105	23	47	47	CD
cord-305263-fgwf6wy3	105	24	]	]	-RRB-
cord-305263-fgwf6wy3	105	25	.	.	.
cord-305263-fgwf6wy3	106	1	Treatment	treatment	NN
cord-305263-fgwf6wy3	106	2	of	of	IN
cord-305263-fgwf6wy3	106	3	a	a	DT
cord-305263-fgwf6wy3	106	4	human	human	JJ
cord-305263-fgwf6wy3	106	5	bronchial	bronchial	JJ
cord-305263-fgwf6wy3	106	6	epithelial	epithelial	JJ
cord-305263-fgwf6wy3	106	7	cell	cell	NN
cord-305263-fgwf6wy3	106	8	line	line	NN
cord-305263-fgwf6wy3	106	9	,	,	,
cord-305263-fgwf6wy3	106	10	Calu-3	Calu-3	NNP
cord-305263-fgwf6wy3	106	11	,	,	,
cord-305263-fgwf6wy3	106	12	with	with	IN
cord-305263-fgwf6wy3	106	13	IFN	IFN	NNP
cord-305263-fgwf6wy3	106	14	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	106	15	before	before	IN
cord-305263-fgwf6wy3	106	16	infection	infection	NN
cord-305263-fgwf6wy3	106	17	with	with	IN
cord-305263-fgwf6wy3	106	18	the	the	DT
cord-305263-fgwf6wy3	106	19	SARS	SARS	NNP
cord-305263-fgwf6wy3	106	20	-	-	HYPH
cord-305263-fgwf6wy3	106	21	CoV	cov	NN
cord-305263-fgwf6wy3	106	22	results	result	NNS
cord-305263-fgwf6wy3	106	23	in	in	IN
cord-305263-fgwf6wy3	106	24	inhibition	inhibition	NN
cord-305263-fgwf6wy3	106	25	of	of	IN
cord-305263-fgwf6wy3	106	26	virus	virus	NN
cord-305263-fgwf6wy3	106	27	infection	infection	NN
cord-305263-fgwf6wy3	106	28	and	and	CC
cord-305263-fgwf6wy3	106	29	a	a	DT
cord-305263-fgwf6wy3	106	30	reduction	reduction	NN
cord-305263-fgwf6wy3	106	31	in	in	IN
cord-305263-fgwf6wy3	106	32	overall	overall	JJ
cord-305263-fgwf6wy3	106	33	virus	virus	NN
cord-305263-fgwf6wy3	106	34	yield	yield	NN
cord-305263-fgwf6wy3	106	35	,	,	,
cord-305263-fgwf6wy3	106	36	further	further	RB
cord-305263-fgwf6wy3	106	37	supporting	support	VBG
cord-305263-fgwf6wy3	106	38	the	the	DT
cord-305263-fgwf6wy3	106	39	idea	idea	NN
cord-305263-fgwf6wy3	106	40	that	that	IN
cord-305263-fgwf6wy3	106	41	IFN	IFN	NNP
cord-305263-fgwf6wy3	106	42	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	106	43	demonstrates	demonstrate	VBZ
cord-305263-fgwf6wy3	106	44	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	106	45	activity	activity	NN
cord-305263-fgwf6wy3	106	46	against	against	IN
cord-305263-fgwf6wy3	106	47	the	the	DT
cord-305263-fgwf6wy3	106	48	SARS	SARS	NNP
cord-305263-fgwf6wy3	106	49	-	-	HYPH
cord-305263-fgwf6wy3	106	50	CoV	CoV	NNP
cord-305263-fgwf6wy3	106	51	[	[	-LRB-
cord-305263-fgwf6wy3	106	52	40	40	CD
cord-305263-fgwf6wy3	106	53	]	]	-RRB-
cord-305263-fgwf6wy3	106	54	.	.	.
cord-305263-fgwf6wy3	107	1	These	these	DT
cord-305263-fgwf6wy3	107	2	data	datum	NNS
cord-305263-fgwf6wy3	107	3	demonstrate	demonstrate	VBP
cord-305263-fgwf6wy3	107	4	that	that	IN
cord-305263-fgwf6wy3	107	5	despite	despite	IN
cord-305263-fgwf6wy3	107	6	the	the	DT
cord-305263-fgwf6wy3	107	7	inherent	inherent	JJ
cord-305263-fgwf6wy3	107	8	ability	ability	NN
cord-305263-fgwf6wy3	107	9	of	of	IN
cord-305263-fgwf6wy3	107	10	the	the	DT
cord-305263-fgwf6wy3	107	11	SARS	SARS	NNP
cord-305263-fgwf6wy3	107	12	-	-	HYPH
cord-305263-fgwf6wy3	107	13	CoV	CoV	NNP
cord-305263-fgwf6wy3	107	14	to	to	TO
cord-305263-fgwf6wy3	107	15	inhibit	inhibit	VB
cord-305263-fgwf6wy3	107	16	IFN	IFN	NNP
cord-305263-fgwf6wy3	107	17	production	production	NN
cord-305263-fgwf6wy3	107	18	and	and	CC
cord-305263-fgwf6wy3	107	19	limit	limit	VB
cord-305263-fgwf6wy3	107	20	an	an	DT
cord-305263-fgwf6wy3	107	21	IFN	IFN	NNP
cord-305263-fgwf6wy3	107	22	response	response	NN
cord-305263-fgwf6wy3	107	23	,	,	,
cord-305263-fgwf6wy3	107	24	treatment	treatment	NN
cord-305263-fgwf6wy3	107	25	with	with	IN
cord-305263-fgwf6wy3	107	26	exogenous	exogenous	JJ
cord-305263-fgwf6wy3	107	27	IFN	IFN	NNP
cord-305263-fgwf6wy3	107	28	-	-	:
cord-305263-fgwf6wy3	107	29	a	a	DT
cord-305263-fgwf6wy3	107	30	overrides	override	VBZ
cord-305263-fgwf6wy3	107	31	these	these	DT
cord-305263-fgwf6wy3	107	32	inhibitory	inhibitory	JJ
cord-305263-fgwf6wy3	107	33	effects	effect	NNS
cord-305263-fgwf6wy3	107	34	.	.	.
cord-305263-fgwf6wy3	108	1	These	these	DT
cord-305263-fgwf6wy3	108	2	results	result	NNS
cord-305263-fgwf6wy3	108	3	support	support	VBP
cord-305263-fgwf6wy3	108	4	the	the	DT
cord-305263-fgwf6wy3	108	5	further	further	JJ
cord-305263-fgwf6wy3	108	6	evaluation	evaluation	NN
cord-305263-fgwf6wy3	108	7	of	of	IN
cord-305263-fgwf6wy3	108	8	IFN	IFN	NNP
cord-305263-fgwf6wy3	108	9	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	108	10	as	as	IN
cord-305263-fgwf6wy3	108	11	a	a	DT
cord-305263-fgwf6wy3	108	12	first	first	JJ
cord-305263-fgwf6wy3	108	13	-	-	HYPH
cord-305263-fgwf6wy3	108	14	line	line	NN
cord-305263-fgwf6wy3	108	15	treatment	treatment	NN
cord-305263-fgwf6wy3	108	16	for	for	IN
cord-305263-fgwf6wy3	108	17	acute	acute	JJ
cord-305263-fgwf6wy3	108	18	SARS	SARS	NNP
cord-305263-fgwf6wy3	108	19	-	-	HYPH
cord-305263-fgwf6wy3	108	20	CoV	CoV	NNP
cord-305263-fgwf6wy3	108	21	infection	infection	NN
cord-305263-fgwf6wy3	108	22	and	and	CC
cord-305263-fgwf6wy3	108	23	approved	approve	VBD
cord-305263-fgwf6wy3	108	24	Inhibits	inhibit	VBZ
cord-305263-fgwf6wy3	108	25	the	the	DT
cord-305263-fgwf6wy3	108	26	function	function	NN
cord-305263-fgwf6wy3	108	27	of	of	IN
cord-305263-fgwf6wy3	108	28	PKR	PKR	NNP
cord-305263-fgwf6wy3	108	29	and	and	CC
cord-305263-fgwf6wy3	108	30	2	2	CD
cord-305263-fgwf6wy3	108	31	0	0	CD
cord-305263-fgwf6wy3	108	32	,	,	,
cord-305263-fgwf6wy3	108	33	5	5	CD
cord-305263-fgwf6wy3	108	34	0	0	CD
cord-305263-fgwf6wy3	108	35	-OAS	-OAS	.
cord-305263-fgwf6wy3	109	1	via	via	IN
cord-305263-fgwf6wy3	109	2	its	-PRON-	PRP$
cord-305263-fgwf6wy3	109	3	dsRNA	dsrna	JJ
cord-305263-fgwf6wy3	109	4	-	-	HYPH
cord-305263-fgwf6wy3	109	5	binding	bind	VBG
cord-305263-fgwf6wy3	109	6	domain	domain	NN
cord-305263-fgwf6wy3	109	7	.	.	.
cord-305263-fgwf6wy3	110	1	[	[	-LRB-
cord-305263-fgwf6wy3	110	2	64	64	CD
cord-305263-fgwf6wy3	110	3	]	]	-RRB-
cord-305263-fgwf6wy3	110	4	Review	Review	NNP
cord-305263-fgwf6wy3	110	5	Trends	Trends	NNPS
cord-305263-fgwf6wy3	110	6	in	in	IN
cord-305263-fgwf6wy3	110	7	Immunology	Immunology	NNP
cord-305263-fgwf6wy3	110	8	April	April	NNP
cord-305263-fgwf6wy3	110	9	2012	2012	CD
cord-305263-fgwf6wy3	110	10	,	,	,
cord-305263-fgwf6wy3	110	11	Vol	Vol	NNP
cord-305263-fgwf6wy3	110	12	.	.	.
cord-305263-fgwf6wy3	111	1	33	33	CD
cord-305263-fgwf6wy3	111	2	,	,	,
cord-305263-fgwf6wy3	111	3	No	no	NN
cord-305263-fgwf6wy3	111	4	.	.	NN
cord-305263-fgwf6wy3	111	5	4	4	CD
cord-305263-fgwf6wy3	111	6	randomized	randomized	JJ
cord-305263-fgwf6wy3	111	7	clinical	clinical	JJ
cord-305263-fgwf6wy3	111	8	trial	trial	NN
cord-305263-fgwf6wy3	111	9	protocols	protocol	NNS
cord-305263-fgwf6wy3	111	10	are	be	VBP
cord-305263-fgwf6wy3	111	11	in	in	IN
cord-305263-fgwf6wy3	111	12	place	place	NN
cord-305263-fgwf6wy3	111	13	in	in	IN
cord-305263-fgwf6wy3	111	14	the	the	DT
cord-305263-fgwf6wy3	111	15	USA	USA	NNP
cord-305263-fgwf6wy3	111	16	and	and	CC
cord-305263-fgwf6wy3	111	17	Canada	Canada	NNP
cord-305263-fgwf6wy3	112	1	should	should	MD
cord-305263-fgwf6wy3	112	2	there	there	EX
cord-305263-fgwf6wy3	112	3	be	be	VB
cord-305263-fgwf6wy3	112	4	outbreaks	outbreak	NNS
cord-305263-fgwf6wy3	112	5	of	of	IN
cord-305263-fgwf6wy3	112	6	SARS	SARS	NNP
cord-305263-fgwf6wy3	112	7	-	-	HYPH
cord-305263-fgwf6wy3	112	8	CoV.	CoV.	NNP
cord-305263-fgwf6wy3	113	1	Seasonal	seasonal	JJ
cord-305263-fgwf6wy3	113	2	influenza	influenza	NN
cord-305263-fgwf6wy3	113	3	A	a	DT
cord-305263-fgwf6wy3	113	4	virus	virus	NN
cord-305263-fgwf6wy3	113	5	infections	infection	NNS
cord-305263-fgwf6wy3	113	6	are	be	VBP
cord-305263-fgwf6wy3	113	7	a	a	DT
cord-305263-fgwf6wy3	113	8	considerable	considerable	JJ
cord-305263-fgwf6wy3	113	9	health	health	NN
cord-305263-fgwf6wy3	113	10	burden	burden	NN
cord-305263-fgwf6wy3	113	11	and	and	CC
cord-305263-fgwf6wy3	113	12	vaccine	vaccine	NN
cord-305263-fgwf6wy3	113	13	programs	program	NNS
cord-305263-fgwf6wy3	113	14	are	be	VBP
cord-305263-fgwf6wy3	113	15	currently	currently	RB
cord-305263-fgwf6wy3	113	16	implemented	implement	VBN
cord-305263-fgwf6wy3	113	17	in	in	IN
cord-305263-fgwf6wy3	113	18	most	most	JJS
cord-305263-fgwf6wy3	113	19	developed	develop	VBN
cord-305263-fgwf6wy3	113	20	countries	country	NNS
cord-305263-fgwf6wy3	113	21	.	.	.
cord-305263-fgwf6wy3	114	1	Vaccines	vaccine	NNS
cord-305263-fgwf6wy3	114	2	,	,	,
cord-305263-fgwf6wy3	114	3	however	however	RB
cord-305263-fgwf6wy3	114	4	,	,	,
cord-305263-fgwf6wy3	114	5	are	be	VBP
cord-305263-fgwf6wy3	114	6	not	not	RB
cord-305263-fgwf6wy3	114	7	relevant	relevant	JJ
cord-305263-fgwf6wy3	114	8	during	during	IN
cord-305263-fgwf6wy3	114	9	an	an	DT
cord-305263-fgwf6wy3	114	10	outbreak	outbreak	NN
cord-305263-fgwf6wy3	114	11	involving	involve	VBG
cord-305263-fgwf6wy3	114	12	an	an	DT
cord-305263-fgwf6wy3	114	13	emergent	emergent	JJ
cord-305263-fgwf6wy3	114	14	variant	variant	NN
cord-305263-fgwf6wy3	114	15	.	.	.
cord-305263-fgwf6wy3	115	1	The	the	DT
cord-305263-fgwf6wy3	115	2	2009	2009	CD
cord-305263-fgwf6wy3	115	3	H1N1	H1N1	NNP
cord-305263-fgwf6wy3	115	4	swine	swine	NN
cord-305263-fgwf6wy3	115	5	-	-	HYPH
cord-305263-fgwf6wy3	115	6	origin	origin	NN
cord-305263-fgwf6wy3	115	7	influenza	influenza	NN
cord-305263-fgwf6wy3	115	8	A	a	DT
cord-305263-fgwf6wy3	115	9	virus	virus	NN
cord-305263-fgwf6wy3	115	10	is	be	VBZ
cord-305263-fgwf6wy3	115	11	a	a	DT
cord-305263-fgwf6wy3	115	12	prime	prime	JJ
cord-305263-fgwf6wy3	115	13	example	example	NN
cord-305263-fgwf6wy3	115	14	of	of	IN
cord-305263-fgwf6wy3	115	15	how	how	WRB
cord-305263-fgwf6wy3	115	16	quickly	quickly	RB
cord-305263-fgwf6wy3	115	17	a	a	DT
cord-305263-fgwf6wy3	115	18	pandemic	pandemic	NN
cord-305263-fgwf6wy3	115	19	can	can	MD
cord-305263-fgwf6wy3	115	20	develop	develop	VB
cord-305263-fgwf6wy3	115	21	given	give	VBN
cord-305263-fgwf6wy3	115	22	the	the	DT
cord-305263-fgwf6wy3	115	23	potential	potential	NN
cord-305263-fgwf6wy3	115	24	for	for	IN
cord-305263-fgwf6wy3	115	25	genetic	genetic	JJ
cord-305263-fgwf6wy3	115	26	shift	shift	NN
cord-305263-fgwf6wy3	115	27	and	and	CC
cord-305263-fgwf6wy3	115	28	mutation	mutation	NN
cord-305263-fgwf6wy3	115	29	of	of	IN
cord-305263-fgwf6wy3	115	30	influenza	influenza	NN
cord-305263-fgwf6wy3	115	31	A	a	DT
cord-305263-fgwf6wy3	115	32	viruses	virus	NNS
cord-305263-fgwf6wy3	115	33	among	among	IN
cord-305263-fgwf6wy3	115	34	natural	natural	JJ
cord-305263-fgwf6wy3	115	35	hosts	host	NNS
cord-305263-fgwf6wy3	115	36	.	.	.
cord-305263-fgwf6wy3	116	1	During	during	IN
cord-305263-fgwf6wy3	116	2	the	the	DT
cord-305263-fgwf6wy3	116	3	2009	2009	CD
cord-305263-fgwf6wy3	116	4	H1N1	H1N1	NNP
cord-305263-fgwf6wy3	116	5	pandemic	pandemic	NN
cord-305263-fgwf6wy3	116	6	,	,	,
cord-305263-fgwf6wy3	116	7	DAAs	daa	NNS
cord-305263-fgwf6wy3	116	8	such	such	JJ
cord-305263-fgwf6wy3	116	9	as	as	IN
cord-305263-fgwf6wy3	116	10	the	the	DT
cord-305263-fgwf6wy3	116	11	neuraminidase	neuraminidase	NN
cord-305263-fgwf6wy3	116	12	inhibitors	inhibitor	NNS
cord-305263-fgwf6wy3	116	13	oseltamivir	oseltamivir	NNP
cord-305263-fgwf6wy3	116	14	and	and	CC
cord-305263-fgwf6wy3	116	15	zanamivir	zanamivir	NNP
cord-305263-fgwf6wy3	116	16	were	be	VBD
cord-305263-fgwf6wy3	116	17	widely	widely	RB
cord-305263-fgwf6wy3	116	18	used	use	VBN
cord-305263-fgwf6wy3	116	19	before	before	IN
cord-305263-fgwf6wy3	116	20	a	a	DT
cord-305263-fgwf6wy3	116	21	vaccine	vaccine	NN
cord-305263-fgwf6wy3	116	22	became	become	VBD
cord-305263-fgwf6wy3	116	23	available	available	JJ
cord-305263-fgwf6wy3	116	24	[	[	-LRB-
cord-305263-fgwf6wy3	116	25	48	48	CD
cord-305263-fgwf6wy3	116	26	]	]	-RRB-
cord-305263-fgwf6wy3	116	27	.	.	.
cord-305263-fgwf6wy3	117	1	Not	not	RB
cord-305263-fgwf6wy3	117	2	surprisingly	surprisingly	RB
cord-305263-fgwf6wy3	117	3	,	,	,
cord-305263-fgwf6wy3	117	4	however	however	RB
cord-305263-fgwf6wy3	117	5	,	,	,
cord-305263-fgwf6wy3	117	6	DAA	DAA	NNP
cord-305263-fgwf6wy3	117	7	-	-	HYPH
cord-305263-fgwf6wy3	117	8	resistant	resistant	JJ
cord-305263-fgwf6wy3	117	9	variants	variant	NNS
cord-305263-fgwf6wy3	117	10	of	of	IN
cord-305263-fgwf6wy3	117	11	pandemic	pandemic	NN
cord-305263-fgwf6wy3	117	12	H1N1	H1N1	NNP
cord-305263-fgwf6wy3	117	13	emerged	emerge	VBD
cord-305263-fgwf6wy3	117	14	[	[	-LRB-
cord-305263-fgwf6wy3	117	15	48	48	CD
cord-305263-fgwf6wy3	117	16	,	,	,
cord-305263-fgwf6wy3	117	17	49	49	CD
cord-305263-fgwf6wy3	117	18	]	]	-RRB-
cord-305263-fgwf6wy3	117	19	.	.	.
cord-305263-fgwf6wy3	118	1	Avian	avian	JJ
cord-305263-fgwf6wy3	118	2	H5N1	H5N1	NNP
cord-305263-fgwf6wy3	118	3	influenza	influenza	NN
cord-305263-fgwf6wy3	118	4	virus	virus	NN
cord-305263-fgwf6wy3	118	5	outbreaks	outbreak	NNS
cord-305263-fgwf6wy3	118	6	,	,	,
cord-305263-fgwf6wy3	118	7	now	now	RB
cord-305263-fgwf6wy3	118	8	affecting	affect	VBG
cord-305263-fgwf6wy3	118	9	populations	population	NNS
cord-305263-fgwf6wy3	118	10	throughout	throughout	IN
cord-305263-fgwf6wy3	118	11	Asia	Asia	NNP
cord-305263-fgwf6wy3	118	12	and	and	CC
cord-305263-fgwf6wy3	118	13	Europe	Europe	NNP
cord-305263-fgwf6wy3	118	14	,	,	,
cord-305263-fgwf6wy3	118	15	are	be	VBP
cord-305263-fgwf6wy3	118	16	associated	associate	VBN
cord-305263-fgwf6wy3	118	17	with	with	IN
cord-305263-fgwf6wy3	118	18	mortality	mortality	NN
cord-305263-fgwf6wy3	118	19	rates	rate	NNS
cord-305263-fgwf6wy3	118	20	around	around	IN
cord-305263-fgwf6wy3	118	21	60	60	CD
cord-305263-fgwf6wy3	118	22	%	%	NN
cord-305263-fgwf6wy3	118	23	[	[	-LRB-
cord-305263-fgwf6wy3	118	24	50	50	CD
cord-305263-fgwf6wy3	118	25	]	]	-RRB-
cord-305263-fgwf6wy3	118	26	.	.	.
cord-305263-fgwf6wy3	119	1	Notably	notably	RB
cord-305263-fgwf6wy3	119	2	,	,	,
cord-305263-fgwf6wy3	119	3	a	a	DT
cord-305263-fgwf6wy3	119	4	number	number	NN
cord-305263-fgwf6wy3	119	5	of	of	IN
cord-305263-fgwf6wy3	119	6	H5N1	H5N1	NNP
cord-305263-fgwf6wy3	119	7	strains	strain	NNS
cord-305263-fgwf6wy3	119	8	are	be	VBP
cord-305263-fgwf6wy3	119	9	resistant	resistant	JJ
cord-305263-fgwf6wy3	119	10	to	to	IN
cord-305263-fgwf6wy3	119	11	oseltamivir	oseltamivir	FW
cord-305263-fgwf6wy3	119	12	[	[	-LRB-
cord-305263-fgwf6wy3	119	13	51	51	CD
cord-305263-fgwf6wy3	119	14	]	]	-RRB-
cord-305263-fgwf6wy3	119	15	.	.	.
cord-305263-fgwf6wy3	120	1	To	to	IN
cord-305263-fgwf6wy3	120	2	date	date	NN
cord-305263-fgwf6wy3	120	3	,	,	,
cord-305263-fgwf6wy3	120	4	there	there	EX
cord-305263-fgwf6wy3	120	5	have	have	VBP
cord-305263-fgwf6wy3	120	6	been	be	VBN
cord-305263-fgwf6wy3	120	7	no	no	DT
cord-305263-fgwf6wy3	120	8	reported	report	VBN
cord-305263-fgwf6wy3	120	9	cases	case	NNS
cord-305263-fgwf6wy3	120	10	of	of	IN
cord-305263-fgwf6wy3	120	11	human	human	NN
cord-305263-fgwf6wy3	120	12	-	-	HYPH
cord-305263-fgwf6wy3	120	13	to	to	IN
cord-305263-fgwf6wy3	120	14	-	-	HYPH
cord-305263-fgwf6wy3	120	15	human	human	JJ
cord-305263-fgwf6wy3	120	16	transmission	transmission	NN
cord-305263-fgwf6wy3	120	17	of	of	IN
cord-305263-fgwf6wy3	120	18	this	this	DT
cord-305263-fgwf6wy3	120	19	lethal	lethal	JJ
cord-305263-fgwf6wy3	120	20	H5N1	H5N1	NNP
cord-305263-fgwf6wy3	120	21	influenza	influenza	NN
cord-305263-fgwf6wy3	120	22	virus	virus	NN
cord-305263-fgwf6wy3	120	23	infection	infection	NN
cord-305263-fgwf6wy3	120	24	,	,	,
cord-305263-fgwf6wy3	120	25	but	but	CC
cord-305263-fgwf6wy3	120	26	if	if	IN
cord-305263-fgwf6wy3	120	27	a	a	DT
cord-305263-fgwf6wy3	120	28	newly	newly	RB
cord-305263-fgwf6wy3	120	29	emerging	emerge	VBG
cord-305263-fgwf6wy3	120	30	strain	strain	NN
cord-305263-fgwf6wy3	120	31	capable	capable	JJ
cord-305263-fgwf6wy3	120	32	of	of	IN
cord-305263-fgwf6wy3	120	33	human	human	NN
cord-305263-fgwf6wy3	120	34	-	-	HYPH
cord-305263-fgwf6wy3	120	35	to	to	IN
cord-305263-fgwf6wy3	120	36	-	-	HYPH
cord-305263-fgwf6wy3	120	37	human	human	JJ
cord-305263-fgwf6wy3	120	38	transmission	transmission	NN
cord-305263-fgwf6wy3	120	39	appears	appear	VBZ
cord-305263-fgwf6wy3	120	40	,	,	,
cord-305263-fgwf6wy3	120	41	DAA	DAA	NNP
cord-305263-fgwf6wy3	120	42	resistance	resistance	NN
cord-305263-fgwf6wy3	120	43	will	will	MD
cord-305263-fgwf6wy3	120	44	develop	develop	VB
cord-305263-fgwf6wy3	120	45	and	and	CC
cord-305263-fgwf6wy3	120	46	until	until	IN
cord-305263-fgwf6wy3	120	47	a	a	DT
cord-305263-fgwf6wy3	120	48	vaccine	vaccine	NN
cord-305263-fgwf6wy3	120	49	becomes	become	VBZ
cord-305263-fgwf6wy3	120	50	availableprobably	availableprobably	RB
cord-305263-fgwf6wy3	120	51	4	4	CD
cord-305263-fgwf6wy3	120	52	-	-	SYM
cord-305263-fgwf6wy3	120	53	6	6	CD
cord-305263-fgwf6wy3	120	54	monthspopulations	monthspopulation	NNS
cord-305263-fgwf6wy3	120	55	will	will	MD
cord-305263-fgwf6wy3	120	56	be	be	VB
cord-305263-fgwf6wy3	120	57	at	at	IN
cord-305263-fgwf6wy3	120	58	risk	risk	NN
cord-305263-fgwf6wy3	120	59	in	in	IN
cord-305263-fgwf6wy3	120	60	the	the	DT
cord-305263-fgwf6wy3	120	61	absence	absence	NN
cord-305263-fgwf6wy3	120	62	of	of	IN
cord-305263-fgwf6wy3	120	63	access	access	NN
cord-305263-fgwf6wy3	120	64	to	to	IN
cord-305263-fgwf6wy3	120	65	broad	broad	JJ
cord-305263-fgwf6wy3	120	66	-	-	HYPH
cord-305263-fgwf6wy3	120	67	spectrum	spectrum	NN
cord-305263-fgwf6wy3	120	68	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	120	69	.	.	.
cord-305263-fgwf6wy3	121	1	NS1	NS1	NNS
cord-305263-fgwf6wy3	121	2	is	be	VBZ
cord-305263-fgwf6wy3	121	3	the	the	DT
cord-305263-fgwf6wy3	121	4	primary	primary	JJ
cord-305263-fgwf6wy3	121	5	virulence	virulence	NN
cord-305263-fgwf6wy3	121	6	factor	factor	NN
cord-305263-fgwf6wy3	121	7	encoded	encode	VBN
cord-305263-fgwf6wy3	121	8	by	by	IN
cord-305263-fgwf6wy3	121	9	influenza	influenza	NN
cord-305263-fgwf6wy3	121	10	A	a	DT
cord-305263-fgwf6wy3	121	11	viruses	virus	NNS
cord-305263-fgwf6wy3	121	12	and	and	CC
cord-305263-fgwf6wy3	121	13	it	-PRON-	PRP
cord-305263-fgwf6wy3	121	14	is	be	VBZ
cord-305263-fgwf6wy3	121	15	expressed	express	VBN
cord-305263-fgwf6wy3	121	16	in	in	IN
cord-305263-fgwf6wy3	121	17	host	host	NN
cord-305263-fgwf6wy3	121	18	cells	cell	NNS
cord-305263-fgwf6wy3	121	19	during	during	IN
cord-305263-fgwf6wy3	121	20	the	the	DT
cord-305263-fgwf6wy3	121	21	earliest	early	JJS
cord-305263-fgwf6wy3	121	22	stages	stage	NNS
cord-305263-fgwf6wy3	121	23	of	of	IN
cord-305263-fgwf6wy3	121	24	infection	infection	NN
cord-305263-fgwf6wy3	121	25	[	[	-LRB-
cord-305263-fgwf6wy3	121	26	15	15	CD
cord-305263-fgwf6wy3	121	27	]	]	-RRB-
cord-305263-fgwf6wy3	121	28	.	.	.
cord-305263-fgwf6wy3	122	1	In	in	IN
cord-305263-fgwf6wy3	122	2	comparison	comparison	NN
cord-305263-fgwf6wy3	122	3	with	with	IN
cord-305263-fgwf6wy3	122	4	SARS	SARS	NNP
cord-305263-fgwf6wy3	122	5	-	-	HYPH
cord-305263-fgwf6wy3	122	6	CoV	CoV	NNP
cord-305263-fgwf6wy3	122	7	Nsp1	Nsp1	NNP
cord-305263-fgwf6wy3	122	8	,	,	,
cord-305263-fgwf6wy3	122	9	influenza	influenza	NN
cord-305263-fgwf6wy3	122	10	virus	virus	NN
cord-305263-fgwf6wy3	122	11	NS1	ns1	NN
cord-305263-fgwf6wy3	122	12	has	have	VBZ
cord-305263-fgwf6wy3	122	13	both	both	DT
cord-305263-fgwf6wy3	122	14	overlapping	overlapping	JJ
cord-305263-fgwf6wy3	122	15	functions	function	NNS
cord-305263-fgwf6wy3	122	16	as	as	RB
cord-305263-fgwf6wy3	122	17	well	well	RB
cord-305263-fgwf6wy3	122	18	as	as	IN
cord-305263-fgwf6wy3	122	19	unique	unique	JJ
cord-305263-fgwf6wy3	122	20	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	122	21	to	to	TO
cord-305263-fgwf6wy3	122	22	inhibit	inhibit	VB
cord-305263-fgwf6wy3	122	23	the	the	DT
cord-305263-fgwf6wy3	122	24	IFN	IFN	NNP
cord-305263-fgwf6wy3	122	25	response	response	NN
cord-305263-fgwf6wy3	122	26	.	.	.
cord-305263-fgwf6wy3	123	1	NS1	ns1	NN
cord-305263-fgwf6wy3	123	2	acts	act	VBZ
cord-305263-fgwf6wy3	123	3	both	both	DT
cord-305263-fgwf6wy3	123	4	in	in	IN
cord-305263-fgwf6wy3	123	5	the	the	DT
cord-305263-fgwf6wy3	123	6	nucleus	nucleus	NN
cord-305263-fgwf6wy3	123	7	and	and	CC
cord-305263-fgwf6wy3	123	8	cytoplasm	cytoplasm	NN
cord-305263-fgwf6wy3	123	9	of	of	IN
cord-305263-fgwf6wy3	123	10	an	an	DT
cord-305263-fgwf6wy3	123	11	infected	infected	JJ
cord-305263-fgwf6wy3	123	12	cell	cell	NN
cord-305263-fgwf6wy3	123	13	,	,	,
cord-305263-fgwf6wy3	123	14	and	and	CC
cord-305263-fgwf6wy3	123	15	is	be	VBZ
cord-305263-fgwf6wy3	123	16	the	the	DT
cord-305263-fgwf6wy3	123	17	primary	primary	JJ
cord-305263-fgwf6wy3	123	18	antagonist	antagonist	NN
cord-305263-fgwf6wy3	123	19	of	of	IN
cord-305263-fgwf6wy3	123	20	the	the	DT
cord-305263-fgwf6wy3	123	21	host	host	NN
cord-305263-fgwf6wy3	123	22	innate	innate	JJ
cord-305263-fgwf6wy3	123	23	immune	immune	JJ
cord-305263-fgwf6wy3	123	24	response	response	NN
cord-305263-fgwf6wy3	123	25	.	.	.
cord-305263-fgwf6wy3	124	1	Remarkably	remarkably	RB
cord-305263-fgwf6wy3	124	2	,	,	,
cord-305263-fgwf6wy3	124	3	NS1	NS1	NNS
cord-305263-fgwf6wy3	124	4	has	have	VBZ
cord-305263-fgwf6wy3	124	5	evolved	evolve	VBN
cord-305263-fgwf6wy3	124	6	to	to	TO
cord-305263-fgwf6wy3	124	7	inhibit	inhibit	VB
cord-305263-fgwf6wy3	124	8	virtually	virtually	RB
cord-305263-fgwf6wy3	124	9	all	all	DT
cord-305263-fgwf6wy3	124	10	stages	stage	NNS
cord-305263-fgwf6wy3	124	11	of	of	IN
cord-305263-fgwf6wy3	124	12	the	the	DT
cord-305263-fgwf6wy3	124	13	IFN	IFN	NNP
cord-305263-fgwf6wy3	124	14	response	response	NN
cord-305263-fgwf6wy3	124	15	to	to	IN
cord-305263-fgwf6wy3	124	16	virus	virus	NN
cord-305263-fgwf6wy3	124	17	infection	infection	NN
cord-305263-fgwf6wy3	124	18	,	,	,
cord-305263-fgwf6wy3	124	19	including	include	VBG
cord-305263-fgwf6wy3	124	20	inhibition	inhibition	NN
cord-305263-fgwf6wy3	124	21	of	of	IN
cord-305263-fgwf6wy3	124	22	IFN	IFN	NNP
cord-305263-fgwf6wy3	124	23	production	production	NN
cord-305263-fgwf6wy3	124	24	,	,	,
cord-305263-fgwf6wy3	124	25	interference	interference	NN
cord-305263-fgwf6wy3	124	26	with	with	IN
cord-305263-fgwf6wy3	124	27	IFN	IFN	NNP
cord-305263-fgwf6wy3	124	28	signaling	signal	VBG
cord-305263-fgwf6wy3	124	29	events	event	NNS
cord-305263-fgwf6wy3	124	30	,	,	,
cord-305263-fgwf6wy3	124	31	and	and	CC
cord-305263-fgwf6wy3	124	32	inhibiting	inhibit	VBG
cord-305263-fgwf6wy3	124	33	the	the	DT
cord-305263-fgwf6wy3	124	34	function	function	NN
cord-305263-fgwf6wy3	124	35	of	of	IN
cord-305263-fgwf6wy3	124	36	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	124	37	factors	factor	NNS
cord-305263-fgwf6wy3	124	38	induced	induce	VBN
cord-305263-fgwf6wy3	124	39	by	by	IN
cord-305263-fgwf6wy3	124	40	IFN	IFN	NNP
cord-305263-fgwf6wy3	124	41	signaling	signal	VBG
cord-305263-fgwf6wy3	124	42	.	.	.
cord-305263-fgwf6wy3	125	1	NS1	NS1	NNS
cord-305263-fgwf6wy3	125	2	inhibits	inhibit	VBZ
cord-305263-fgwf6wy3	125	3	the	the	DT
cord-305263-fgwf6wy3	125	4	activity	activity	NN
cord-305263-fgwf6wy3	125	5	of	of	IN
cord-305263-fgwf6wy3	125	6	RIG	rig	NN
cord-305263-fgwf6wy3	125	7	-	-	:
cord-305263-fgwf6wy3	125	8	I	I	NNP
cord-305263-fgwf6wy3	125	9	(	(	-LRB-
cord-305263-fgwf6wy3	125	10	Box	Box	NNP
cord-305263-fgwf6wy3	125	11	1	1	CD
cord-305263-fgwf6wy3	125	12	)	)	-RRB-
cord-305263-fgwf6wy3	125	13	where	where	WRB
cord-305263-fgwf6wy3	125	14	the	the	DT
cord-305263-fgwf6wy3	125	15	NS1	ns1	NN
cord-305263-fgwf6wy3	125	16	dsRNA	dsrna	JJ
cord-305263-fgwf6wy3	125	17	-	-	HYPH
cord-305263-fgwf6wy3	125	18	binding	bind	VBG
cord-305263-fgwf6wy3	125	19	domain	domain	NN
cord-305263-fgwf6wy3	125	20	interacts	interact	VBZ
cord-305263-fgwf6wy3	125	21	directly	directly	RB
cord-305263-fgwf6wy3	125	22	with	with	IN
cord-305263-fgwf6wy3	125	23	RIG-	RIG-	NNP
cord-305263-fgwf6wy3	126	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	126	2	[	[	-LRB-
cord-305263-fgwf6wy3	126	3	15	15	CD
cord-305263-fgwf6wy3	126	4	]	]	-RRB-
cord-305263-fgwf6wy3	126	5	.	.	.
cord-305263-fgwf6wy3	127	1	Within	within	IN
cord-305263-fgwf6wy3	127	2	the	the	DT
cord-305263-fgwf6wy3	127	3	nucleus	nucleus	NN
cord-305263-fgwf6wy3	127	4	of	of	IN
cord-305263-fgwf6wy3	127	5	an	an	DT
cord-305263-fgwf6wy3	127	6	infected	infected	JJ
cord-305263-fgwf6wy3	127	7	cell	cell	NN
cord-305263-fgwf6wy3	127	8	,	,	,
cord-305263-fgwf6wy3	127	9	NS1	NS1	NNS
cord-305263-fgwf6wy3	127	10	inhibits	inhibit	VBZ
cord-305263-fgwf6wy3	127	11	the	the	DT
cord-305263-fgwf6wy3	127	12	processing	processing	NN
cord-305263-fgwf6wy3	127	13	and	and	CC
cord-305263-fgwf6wy3	127	14	synthesis	synthesis	NN
cord-305263-fgwf6wy3	127	15	of	of	IN
cord-305263-fgwf6wy3	127	16	host	host	NN
cord-305263-fgwf6wy3	127	17	mRNAs	mrnas	CD
cord-305263-fgwf6wy3	127	18	,	,	,
cord-305263-fgwf6wy3	127	19	including	include	VBG
cord-305263-fgwf6wy3	127	20	IFN	IFN	NNP
cord-305263-fgwf6wy3	127	21	-	-	HYPH
cord-305263-fgwf6wy3	127	22	a	a	NN
cord-305263-fgwf6wy3	127	23	/	/	SYM
cord-305263-fgwf6wy3	127	24	b	b	NN
cord-305263-fgwf6wy3	127	25	mRNAs	mRNAs	NNP
cord-305263-fgwf6wy3	127	26	,	,	,
cord-305263-fgwf6wy3	127	27	by	by	IN
cord-305263-fgwf6wy3	127	28	binding	bind	VBG
cord-305263-fgwf6wy3	127	29	to	to	IN
cord-305263-fgwf6wy3	127	30	and	and	CC
cord-305263-fgwf6wy3	127	31	inhibiting	inhibit	VBG
cord-305263-fgwf6wy3	127	32	both	both	DT
cord-305263-fgwf6wy3	127	33	cleavage	cleavage	NN
cord-305263-fgwf6wy3	127	34	and	and	CC
cord-305263-fgwf6wy3	127	35	polyadenylation	polyadenylation	NN
cord-305263-fgwf6wy3	127	36	specific	specific	JJ
cord-305263-fgwf6wy3	127	37	factor	factor	NN
cord-305263-fgwf6wy3	127	38	30	30	CD
cord-305263-fgwf6wy3	127	39	kDa	kDa	NNS
cord-305263-fgwf6wy3	127	40	(	(	-LRB-
cord-305263-fgwf6wy3	127	41	CPSF30	CPSF30	NNP
cord-305263-fgwf6wy3	127	42	)	)	-RRB-
cord-305263-fgwf6wy3	127	43	and	and	CC
cord-305263-fgwf6wy3	127	44	poly(A)-binding	poly(a)-binde	VBG
cord-305263-fgwf6wy3	127	45	protein	protein	NN
cord-305263-fgwf6wy3	127	46	II	II	NNP
cord-305263-fgwf6wy3	127	47	(	(	-LRB-
cord-305263-fgwf6wy3	127	48	PABPII	PABPII	NNP
cord-305263-fgwf6wy3	127	49	)	)	-RRB-
cord-305263-fgwf6wy3	127	50	,	,	,
cord-305263-fgwf6wy3	127	51	via	via	IN
cord-305263-fgwf6wy3	127	52	its	-PRON-	PRP$
cord-305263-fgwf6wy3	127	53	proteinbinding	proteinbinding	NN
cord-305263-fgwf6wy3	127	54	domain	domain	NN
cord-305263-fgwf6wy3	127	55	[	[	-LRB-
cord-305263-fgwf6wy3	127	56	15	15	CD
cord-305263-fgwf6wy3	127	57	]	]	-RRB-
cord-305263-fgwf6wy3	127	58	.	.	.
cord-305263-fgwf6wy3	128	1	The	the	DT
cord-305263-fgwf6wy3	128	2	expression	expression	NN
cord-305263-fgwf6wy3	128	3	of	of	IN
cord-305263-fgwf6wy3	128	4	avian	avian	JJ
cord-305263-fgwf6wy3	128	5	H5N1	H5N1	NNP
cord-305263-fgwf6wy3	128	6	NS1	NS1	NNS
cord-305263-fgwf6wy3	128	7	disrupts	disrupt	VBZ
cord-305263-fgwf6wy3	128	8	IFN	IFN	NNP
cord-305263-fgwf6wy3	128	9	signaling	signal	VBG
cord-305263-fgwf6wy3	128	10	events	event	NNS
cord-305263-fgwf6wy3	128	11	by	by	IN
cord-305263-fgwf6wy3	128	12	downregulating	downregulate	VBG
cord-305263-fgwf6wy3	128	13	the	the	DT
cord-305263-fgwf6wy3	128	14	surface	surface	NN
cord-305263-fgwf6wy3	128	15	expression	expression	NN
cord-305263-fgwf6wy3	128	16	of	of	IN
cord-305263-fgwf6wy3	128	17	one	one	CD
cord-305263-fgwf6wy3	128	18	of	of	IN
cord-305263-fgwf6wy3	128	19	the	the	DT
cord-305263-fgwf6wy3	128	20	IFNAR	IFNAR	NNP
cord-305263-fgwf6wy3	128	21	subunits	subunit	NNS
cord-305263-fgwf6wy3	128	22	,	,	,
cord-305263-fgwf6wy3	128	23	IFNAR1	IFNAR1	NNP
cord-305263-fgwf6wy3	128	24	,	,	,
cord-305263-fgwf6wy3	128	25	and	and	CC
cord-305263-fgwf6wy3	128	26	by	by	IN
cord-305263-fgwf6wy3	128	27	upregulating	upregulate	VBG
cord-305263-fgwf6wy3	128	28	SOCS1	SOCS1	NNP
cord-305263-fgwf6wy3	128	29	protein	protein	NN
cord-305263-fgwf6wy3	128	30	expression	expression	NN
cord-305263-fgwf6wy3	128	31	,	,	,
cord-305263-fgwf6wy3	128	32	leading	lead	VBG
cord-305263-fgwf6wy3	128	33	to	to	IN
cord-305263-fgwf6wy3	128	34	a	a	DT
cord-305263-fgwf6wy3	128	35	reduction	reduction	NN
cord-305263-fgwf6wy3	128	36	in	in	IN
cord-305263-fgwf6wy3	128	37	IFN	IFN	NNP
cord-305263-fgwf6wy3	128	38	-	-	HYPH
cord-305263-fgwf6wy3	128	39	inducible	inducible	JJ
cord-305263-fgwf6wy3	128	40	STAT	stat	NN
cord-305263-fgwf6wy3	128	41	phosphorylation	phosphorylation	NN
cord-305263-fgwf6wy3	128	42	and	and	CC
cord-305263-fgwf6wy3	128	43	STAT	stat	NN
cord-305263-fgwf6wy3	128	44	homo	homo	NN
cord-305263-fgwf6wy3	128	45	/	/	SYM
cord-305263-fgwf6wy3	128	46	heterodimer	heterodimer	NN
cord-305263-fgwf6wy3	128	47	nuclear	nuclear	JJ
cord-305263-fgwf6wy3	128	48	translocation	translocation	NN
cord-305263-fgwf6wy3	128	49	[	[	-LRB-
cord-305263-fgwf6wy3	128	50	20	20	CD
cord-305263-fgwf6wy3	128	51	]	]	-RRB-
cord-305263-fgwf6wy3	128	52	.	.	.
cord-305263-fgwf6wy3	129	1	NS1	NS1	NNS
cord-305263-fgwf6wy3	129	2	is	be	VBZ
cord-305263-fgwf6wy3	129	3	able	able	JJ
cord-305263-fgwf6wy3	129	4	to	to	TO
cord-305263-fgwf6wy3	129	5	block	block	VB
cord-305263-fgwf6wy3	129	6	directly	directly	RB
cord-305263-fgwf6wy3	129	7	the	the	DT
cord-305263-fgwf6wy3	129	8	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	129	9	activities	activity	NNS
cord-305263-fgwf6wy3	129	10	of	of	IN
cord-305263-fgwf6wy3	129	11	IFNinducible	ifninducible	JJ
cord-305263-fgwf6wy3	129	12	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	129	13	proteins	protein	NNS
cord-305263-fgwf6wy3	129	14	such	such	JJ
cord-305263-fgwf6wy3	129	15	as	as	IN
cord-305263-fgwf6wy3	129	16	protein	protein	NN
cord-305263-fgwf6wy3	129	17	kinase	kinase	NN
cord-305263-fgwf6wy3	129	18	RNAactivated	rnaactivate	VBN
cord-305263-fgwf6wy3	129	19	(	(	-LRB-
cord-305263-fgwf6wy3	129	20	PKR	PKR	NNP
cord-305263-fgwf6wy3	129	21	)	)	-RRB-
cord-305263-fgwf6wy3	129	22	and	and	CC
cord-305263-fgwf6wy3	129	23	2	2	CD
cord-305263-fgwf6wy3	129	24	0	0	CD
cord-305263-fgwf6wy3	129	25	,	,	,
cord-305263-fgwf6wy3	129	26	5	5	CD
cord-305263-fgwf6wy3	129	27	0	0	CD
cord-305263-fgwf6wy3	129	28	-OAS	-oas	ADD
cord-305263-fgwf6wy3	129	29	/	/	SYM
cord-305263-fgwf6wy3	129	30	RNaseL	RNaseL	NNP
cord-305263-fgwf6wy3	129	31	,	,	,
cord-305263-fgwf6wy3	129	32	via	via	IN
cord-305263-fgwf6wy3	129	33	its	-PRON-	PRP$
cord-305263-fgwf6wy3	129	34	proteinbinding	proteinbinde	VBG
cord-305263-fgwf6wy3	129	35	domain	domain	NN
cord-305263-fgwf6wy3	129	36	and	and	CC
cord-305263-fgwf6wy3	129	37	dsRNA	dsrna	RB
cord-305263-fgwf6wy3	129	38	-	-	HYPH
cord-305263-fgwf6wy3	129	39	binding	bind	VBG
cord-305263-fgwf6wy3	129	40	domain	domain	NN
cord-305263-fgwf6wy3	129	41	,	,	,
cord-305263-fgwf6wy3	129	42	respectively	respectively	RB
cord-305263-fgwf6wy3	129	43	[	[	-LRB-
cord-305263-fgwf6wy3	129	44	15	15	CD
cord-305263-fgwf6wy3	129	45	]	]	-RRB-
cord-305263-fgwf6wy3	129	46	.	.	.
cord-305263-fgwf6wy3	130	1	The	the	DT
cord-305263-fgwf6wy3	130	2	Src	Src	NNP
cord-305263-fgwf6wy3	130	3	homology	homology	NN
cord-305263-fgwf6wy3	130	4	2	2	CD
cord-305263-fgwf6wy3	130	5	(	(	-LRB-
cord-305263-fgwf6wy3	130	6	SH2)-binding	sh2)-binde	VBG
cord-305263-fgwf6wy3	130	7	domain	domain	NN
cord-305263-fgwf6wy3	130	8	within	within	IN
cord-305263-fgwf6wy3	130	9	the	the	DT
cord-305263-fgwf6wy3	130	10	protein	protein	NN
cord-305263-fgwf6wy3	130	11	-	-	HYPH
cord-305263-fgwf6wy3	130	12	binding	bind	VBG
cord-305263-fgwf6wy3	130	13	region	region	NN
cord-305263-fgwf6wy3	130	14	of	of	IN
cord-305263-fgwf6wy3	130	15	NS1	NS1	NNS
cord-305263-fgwf6wy3	130	16	permits	permit	VBZ
cord-305263-fgwf6wy3	130	17	interaction	interaction	NN
cord-305263-fgwf6wy3	130	18	with	with	IN
cord-305263-fgwf6wy3	130	19	the	the	DT
cord-305263-fgwf6wy3	130	20	internal	internal	JJ
cord-305263-fgwf6wy3	130	21	SH2	SH2	NNP
cord-305263-fgwf6wy3	130	22	domain	domain	NN
cord-305263-fgwf6wy3	130	23	of	of	IN
cord-305263-fgwf6wy3	130	24	p85b	p85b	NNS
cord-305263-fgwf6wy3	130	25	,	,	,
cord-305263-fgwf6wy3	130	26	the	the	DT
cord-305263-fgwf6wy3	130	27	inhibitory	inhibitory	JJ
cord-305263-fgwf6wy3	130	28	subunit	subunit	NN
cord-305263-fgwf6wy3	130	29	of	of	IN
cord-305263-fgwf6wy3	130	30	phosphoinositide	phosphoinositide	JJ
cord-305263-fgwf6wy3	130	31	3-kinase	3-kinase	CD
cord-305263-fgwf6wy3	130	32	(	(	-LRB-
cord-305263-fgwf6wy3	130	33	PI3	PI3	NNP
cord-305263-fgwf6wy3	130	34	K	K	NNP
cord-305263-fgwf6wy3	130	35	)	)	-RRB-
cord-305263-fgwf6wy3	130	36	.	.	.
cord-305263-fgwf6wy3	131	1	This	this	DT
cord-305263-fgwf6wy3	131	2	leads	lead	VBZ
cord-305263-fgwf6wy3	131	3	to	to	IN
cord-305263-fgwf6wy3	131	4	activation	activation	NN
cord-305263-fgwf6wy3	131	5	of	of	IN
cord-305263-fgwf6wy3	131	6	the	the	DT
cord-305263-fgwf6wy3	131	7	PI3K	PI3K	NNP
cord-305263-fgwf6wy3	131	8	-	-	HYPH
cord-305263-fgwf6wy3	131	9	AKT	AKT	NNP
cord-305263-fgwf6wy3	131	10	pathway	pathway	NN
cord-305263-fgwf6wy3	131	11	[	[	-LRB-
cord-305263-fgwf6wy3	131	12	15	15	CD
cord-305263-fgwf6wy3	131	13	]	]	-RRB-
cord-305263-fgwf6wy3	131	14	.	.	.
cord-305263-fgwf6wy3	132	1	Activation	activation	NN
cord-305263-fgwf6wy3	132	2	of	of	IN
cord-305263-fgwf6wy3	132	3	PI3	PI3	NNP
cord-305263-fgwf6wy3	132	4	K	K	NNP
cord-305263-fgwf6wy3	132	5	,	,	,
cord-305263-fgwf6wy3	132	6	a	a	DT
cord-305263-fgwf6wy3	132	7	downstream	downstream	JJ
cord-305263-fgwf6wy3	132	8	target	target	NN
cord-305263-fgwf6wy3	132	9	of	of	IN
cord-305263-fgwf6wy3	132	10	IFN	IFN	NNP
cord-305263-fgwf6wy3	132	11	-	-	HYPH
cord-305263-fgwf6wy3	132	12	a	a	NNP
cord-305263-fgwf6wy3	132	13	/	/	SYM
cord-305263-fgwf6wy3	132	14	b	b	NN
cord-305263-fgwf6wy3	132	15	signaling	signaling	NN
cord-305263-fgwf6wy3	132	16	,	,	,
cord-305263-fgwf6wy3	132	17	by	by	IN
cord-305263-fgwf6wy3	132	18	a	a	DT
cord-305263-fgwf6wy3	132	19	specific	specific	JJ
cord-305263-fgwf6wy3	132	20	NS1	ns1	NN
cord-305263-fgwf6wy3	132	21	promotes	promote	VBZ
cord-305263-fgwf6wy3	132	22	cell	cell	NN
cord-305263-fgwf6wy3	132	23	survival	survival	NN
cord-305263-fgwf6wy3	132	24	during	during	IN
cord-305263-fgwf6wy3	132	25	the	the	DT
cord-305263-fgwf6wy3	132	26	early	early	JJ
cord-305263-fgwf6wy3	132	27	stages	stage	NNS
cord-305263-fgwf6wy3	132	28	of	of	IN
cord-305263-fgwf6wy3	132	29	infection	infection	NN
cord-305263-fgwf6wy3	132	30	,	,	,
cord-305263-fgwf6wy3	132	31	illustrating	illustrate	VBG
cord-305263-fgwf6wy3	132	32	the	the	DT
cord-305263-fgwf6wy3	132	33	complex	complex	JJ
cord-305263-fgwf6wy3	132	34	interplay	interplay	NN
cord-305263-fgwf6wy3	132	35	between	between	IN
cord-305263-fgwf6wy3	132	36	virus	virus	NN
cord-305263-fgwf6wy3	132	37	encoded	encode	VBN
cord-305263-fgwf6wy3	132	38	factors	factor	NNS
cord-305263-fgwf6wy3	132	39	and	and	CC
cord-305263-fgwf6wy3	132	40	the	the	DT
cord-305263-fgwf6wy3	132	41	IFN	IFN	NNP
cord-305263-fgwf6wy3	132	42	-	-	HYPH
cord-305263-fgwf6wy3	132	43	a	a	NNP
cord-305263-fgwf6wy3	132	44	/	/	SYM
cord-305263-fgwf6wy3	132	45	b	b	NN
cord-305263-fgwf6wy3	132	46	response	response	NN
cord-305263-fgwf6wy3	132	47	[	[	-LRB-
cord-305263-fgwf6wy3	132	48	15	15	CD
cord-305263-fgwf6wy3	132	49	]	]	-RRB-
cord-305263-fgwf6wy3	132	50	.	.	.
cord-305263-fgwf6wy3	133	1	Remarkably	remarkably	RB
cord-305263-fgwf6wy3	133	2	,	,	,
cord-305263-fgwf6wy3	133	3	distinct	distinct	JJ
cord-305263-fgwf6wy3	133	4	highly	highly	RB
cord-305263-fgwf6wy3	133	5	pathogenic	pathogenic	JJ
cord-305263-fgwf6wy3	133	6	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	133	7	viruses	virus	NNS
cord-305263-fgwf6wy3	133	8	,	,	,
cord-305263-fgwf6wy3	133	9	namely	namely	RB
cord-305263-fgwf6wy3	133	10	influenza	influenza	NN
cord-305263-fgwf6wy3	133	11	viruses	virus	NNS
cord-305263-fgwf6wy3	133	12	and	and	CC
cord-305263-fgwf6wy3	133	13	the	the	DT
cord-305263-fgwf6wy3	133	14	SARS	SARS	NNP
cord-305263-fgwf6wy3	133	15	-	-	HYPH
cord-305263-fgwf6wy3	133	16	CoV	CoV	NNP
cord-305263-fgwf6wy3	133	17	,	,	,
cord-305263-fgwf6wy3	133	18	encode	encode	VB
cord-305263-fgwf6wy3	133	19	nonstructural	nonstructural	JJ
cord-305263-fgwf6wy3	133	20	proteins	protein	NNS
cord-305263-fgwf6wy3	133	21	in	in	IN
cord-305263-fgwf6wy3	133	22	their	-PRON-	PRP$
cord-305263-fgwf6wy3	133	23	genomes	genome	NNS
cord-305263-fgwf6wy3	133	24	that	that	WDT
cord-305263-fgwf6wy3	133	25	function	function	VBP
cord-305263-fgwf6wy3	133	26	as	as	IN
cord-305263-fgwf6wy3	133	27	virulence	virulence	NN
cord-305263-fgwf6wy3	133	28	factors	factor	NNS
cord-305263-fgwf6wy3	133	29	that	that	WDT
cord-305263-fgwf6wy3	133	30	specifically	specifically	RB
cord-305263-fgwf6wy3	133	31	target	target	VBP
cord-305263-fgwf6wy3	133	32	the	the	DT
cord-305263-fgwf6wy3	133	33	host	host	NN
cord-305263-fgwf6wy3	133	34	innate	innate	VBP
cord-305263-fgwf6wy3	133	35	IFN	IFN	NNP
cord-305263-fgwf6wy3	133	36	response	response	NN
cord-305263-fgwf6wy3	133	37	,	,	,
cord-305263-fgwf6wy3	133	38	further	further	RB
cord-305263-fgwf6wy3	133	39	emphasizing	emphasize	VBG
cord-305263-fgwf6wy3	133	40	the	the	DT
cord-305263-fgwf6wy3	133	41	importance	importance	NN
cord-305263-fgwf6wy3	133	42	of	of	IN
cord-305263-fgwf6wy3	133	43	IFNs	ifn	NNS
cord-305263-fgwf6wy3	133	44	as	as	IN
cord-305263-fgwf6wy3	133	45	broad	broad	JJ
cord-305263-fgwf6wy3	133	46	-	-	HYPH
cord-305263-fgwf6wy3	133	47	spectrum	spectrum	NN
cord-305263-fgwf6wy3	133	48	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	133	49	.	.	.
cord-305263-fgwf6wy3	134	1	A	a	DT
cord-305263-fgwf6wy3	134	2	recently	recently	RB
cord-305263-fgwf6wy3	134	3	completed	complete	VBN
cord-305263-fgwf6wy3	134	4	randomized	randomized	JJ
cord-305263-fgwf6wy3	134	5	controlled	control	VBN
cord-305263-fgwf6wy3	134	6	trial	trial	NN
cord-305263-fgwf6wy3	134	7	has	have	VBZ
cord-305263-fgwf6wy3	134	8	examined	examine	VBN
cord-305263-fgwf6wy3	134	9	the	the	DT
cord-305263-fgwf6wy3	134	10	safety	safety	NN
cord-305263-fgwf6wy3	134	11	and	and	CC
cord-305263-fgwf6wy3	134	12	efficacy	efficacy	NN
cord-305263-fgwf6wy3	134	13	of	of	IN
cord-305263-fgwf6wy3	134	14	recombinant	recombinant	JJ
cord-305263-fgwf6wy3	134	15	IFN	IFN	NNP
cord-305263-fgwf6wy3	134	16	-	-	HYPH
cord-305263-fgwf6wy3	134	17	a	a	DT
cord-305263-fgwf6wy3	134	18	(	(	-LRB-
cord-305263-fgwf6wy3	134	19	rIFN	rifn	NN
cord-305263-fgwf6wy3	134	20	-	-	:
cord-305263-fgwf6wy3	134	21	a	a	DT
cord-305263-fgwf6wy3	134	22	)	)	-RRB-
cord-305263-fgwf6wy3	134	23	treatment	treatment	NN
cord-305263-fgwf6wy3	134	24	,	,	,
cord-305263-fgwf6wy3	134	25	administered	administer	VBN
cord-305263-fgwf6wy3	134	26	in	in	IN
cord-305263-fgwf6wy3	134	27	the	the	DT
cord-305263-fgwf6wy3	134	28	form	form	NN
cord-305263-fgwf6wy3	134	29	of	of	IN
cord-305263-fgwf6wy3	134	30	a	a	DT
cord-305263-fgwf6wy3	134	31	nasal	nasal	NN
cord-305263-fgwf6wy3	134	32	spray	spray	NN
cord-305263-fgwf6wy3	134	33	,	,	,
cord-305263-fgwf6wy3	134	34	in	in	IN
cord-305263-fgwf6wy3	134	35	military	military	JJ
cord-305263-fgwf6wy3	134	36	recruits	recruit	NNS
cord-305263-fgwf6wy3	134	37	,	,	,
cord-305263-fgwf6wy3	134	38	in	in	IN
cord-305263-fgwf6wy3	134	39	the	the	DT
cord-305263-fgwf6wy3	134	40	context	context	NN
cord-305263-fgwf6wy3	134	41	of	of	IN
cord-305263-fgwf6wy3	134	42	protection	protection	NN
cord-305263-fgwf6wy3	134	43	from	from	IN
cord-305263-fgwf6wy3	134	44	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	134	45	virus	virus	NN
cord-305263-fgwf6wy3	134	46	infections	infection	NNS
cord-305263-fgwf6wy3	134	47	[	[	-LRB-
cord-305263-fgwf6wy3	134	48	52	52	CD
cord-305263-fgwf6wy3	134	49	]	]	-RRB-
cord-305263-fgwf6wy3	134	50	.	.	.
cord-305263-fgwf6wy3	135	1	Serum	serum	NN
cord-305263-fgwf6wy3	135	2	IgM	igm	NN
cord-305263-fgwf6wy3	135	3	levels	level	NNS
cord-305263-fgwf6wy3	135	4	were	be	VBD
cord-305263-fgwf6wy3	135	5	measured	measure	VBN
cord-305263-fgwf6wy3	135	6	as	as	IN
cord-305263-fgwf6wy3	135	7	evidence	evidence	NN
cord-305263-fgwf6wy3	135	8	of	of	IN
cord-305263-fgwf6wy3	135	9	virus	virus	NN
cord-305263-fgwf6wy3	135	10	infection	infection	NN
cord-305263-fgwf6wy3	135	11	.	.	.
cord-305263-fgwf6wy3	136	1	Subjects	subject	NNS
cord-305263-fgwf6wy3	136	2	receiving	receive	VBG
cord-305263-fgwf6wy3	136	3	rIFN	rifn	NN
cord-305263-fgwf6wy3	136	4	-	-	:
cord-305263-fgwf6wy3	136	5	a	a	NN
cord-305263-fgwf6wy3	136	6	had	have	VBD
cord-305263-fgwf6wy3	136	7	lower	low	JJR
cord-305263-fgwf6wy3	136	8	concentrations	concentration	NNS
cord-305263-fgwf6wy3	136	9	of	of	IN
cord-305263-fgwf6wy3	136	10	serum	serum	NN
cord-305263-fgwf6wy3	136	11	IgM	igm	NN
cord-305263-fgwf6wy3	136	12	specific	specific	JJ
cord-305263-fgwf6wy3	136	13	for	for	IN
cord-305263-fgwf6wy3	136	14	H3N2	H3N2	NNP
cord-305263-fgwf6wy3	136	15	influenza	influenza	NN
cord-305263-fgwf6wy3	136	16	A	a	DT
cord-305263-fgwf6wy3	136	17	virus	virus	NN
cord-305263-fgwf6wy3	136	18	,	,	,
cord-305263-fgwf6wy3	136	19	influenza	influenza	NN
cord-305263-fgwf6wy3	136	20	B	b	NN
cord-305263-fgwf6wy3	136	21	virus	virus	NN
cord-305263-fgwf6wy3	136	22	,	,	,
cord-305263-fgwf6wy3	136	23	adenovirus	adenovirus	NN
cord-305263-fgwf6wy3	136	24	(	(	-LRB-
cord-305263-fgwf6wy3	136	25	species	specie	NNS
cord-305263-fgwf6wy3	136	26	B	B	NNP
cord-305263-fgwf6wy3	136	27	)	)	-RRB-
cord-305263-fgwf6wy3	136	28	,	,	,
cord-305263-fgwf6wy3	136	29	and	and	CC
cord-305263-fgwf6wy3	136	30	parainfluenza	parainfluenza	NNP
cord-305263-fgwf6wy3	136	31	virus	virus	NN
cord-305263-fgwf6wy3	136	32	types	type	NNS
cord-305263-fgwf6wy3	136	33	1	1	CD
cord-305263-fgwf6wy3	136	34	,	,	,
cord-305263-fgwf6wy3	136	35	2	2	CD
cord-305263-fgwf6wy3	136	36	and	and	CC
cord-305263-fgwf6wy3	136	37	3	3	CD
cord-305263-fgwf6wy3	136	38	[	[	-LRB-
cord-305263-fgwf6wy3	136	39	52	52	CD
cord-305263-fgwf6wy3	136	40	]	]	-RRB-
cord-305263-fgwf6wy3	136	41	.	.	.
cord-305263-fgwf6wy3	137	1	Specifically	specifically	RB
cord-305263-fgwf6wy3	137	2	with	with	IN
cord-305263-fgwf6wy3	137	3	regard	regard	NN
cord-305263-fgwf6wy3	137	4	to	to	IN
cord-305263-fgwf6wy3	137	5	influenza	influenza	NN
cord-305263-fgwf6wy3	137	6	A	a	DT
cord-305263-fgwf6wy3	137	7	virus	virus	NN
cord-305263-fgwf6wy3	137	8	,	,	,
cord-305263-fgwf6wy3	137	9	only	only	RB
cord-305263-fgwf6wy3	137	10	30	30	CD
cord-305263-fgwf6wy3	137	11	recruits	recruit	NNS
cord-305263-fgwf6wy3	137	12	treated	treat	VBN
cord-305263-fgwf6wy3	137	13	with	with	IN
cord-305263-fgwf6wy3	137	14	rIFN	rifn	NN
cord-305263-fgwf6wy3	137	15	-	-	:
cord-305263-fgwf6wy3	137	16	a	a	DT
cord-305263-fgwf6wy3	137	17	had	have	VBD
cord-305263-fgwf6wy3	137	18	detectable	detectable	JJ
cord-305263-fgwf6wy3	137	19	levels	level	NNS
cord-305263-fgwf6wy3	137	20	of	of	IN
cord-305263-fgwf6wy3	137	21	influenza	influenza	NN
cord-305263-fgwf6wy3	137	22	A	a	DT
cord-305263-fgwf6wy3	137	23	virus	virus	NN
cord-305263-fgwf6wy3	137	24	IgM	igm	NN
cord-305263-fgwf6wy3	137	25	compared	compare	VBN
cord-305263-fgwf6wy3	137	26	with	with	IN
cord-305263-fgwf6wy3	137	27	104	104	CD
cord-305263-fgwf6wy3	137	28	recruits	recruit	NNS
cord-305263-fgwf6wy3	137	29	in	in	IN
cord-305263-fgwf6wy3	137	30	the	the	DT
cord-305263-fgwf6wy3	137	31	untreated	untreated	JJ
cord-305263-fgwf6wy3	137	32	control	control	NN
cord-305263-fgwf6wy3	137	33	group	group	NN
cord-305263-fgwf6wy3	137	34	[	[	-LRB-
cord-305263-fgwf6wy3	137	35	52	52	CD
cord-305263-fgwf6wy3	137	36	]	]	-RRB-
cord-305263-fgwf6wy3	137	37	.	.	.
cord-305263-fgwf6wy3	138	1	No	no	DT
cord-305263-fgwf6wy3	138	2	adverse	adverse	JJ
cord-305263-fgwf6wy3	138	3	events	event	NNS
cord-305263-fgwf6wy3	138	4	were	be	VBD
cord-305263-fgwf6wy3	138	5	reported	report	VBN
cord-305263-fgwf6wy3	138	6	in	in	IN
cord-305263-fgwf6wy3	138	7	the	the	DT
cord-305263-fgwf6wy3	138	8	treatment	treatment	NN
cord-305263-fgwf6wy3	138	9	group	group	NN
cord-305263-fgwf6wy3	138	10	,	,	,
cord-305263-fgwf6wy3	138	11	the	the	DT
cord-305263-fgwf6wy3	138	12	data	datum	NNS
cord-305263-fgwf6wy3	138	13	demonstrating	demonstrate	VBG
cord-305263-fgwf6wy3	138	14	that	that	IN
cord-305263-fgwf6wy3	138	15	IFN	IFN	NNP
cord-305263-fgwf6wy3	138	16	was	be	VBD
cord-305263-fgwf6wy3	138	17	well	well	RB
cord-305263-fgwf6wy3	138	18	tolerated	tolerate	VBN
cord-305263-fgwf6wy3	138	19	and	and	CC
cord-305263-fgwf6wy3	138	20	was	be	VBD
cord-305263-fgwf6wy3	138	21	effective	effective	JJ
cord-305263-fgwf6wy3	138	22	in	in	IN
cord-305263-fgwf6wy3	138	23	preventing	prevent	VBG
cord-305263-fgwf6wy3	138	24	a	a	DT
cord-305263-fgwf6wy3	138	25	variety	variety	NN
cord-305263-fgwf6wy3	138	26	of	of	IN
cord-305263-fgwf6wy3	138	27	common	common	JJ
cord-305263-fgwf6wy3	138	28	viral	viral	JJ
cord-305263-fgwf6wy3	138	29	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	138	30	infections	infection	NNS
cord-305263-fgwf6wy3	138	31	.	.	.
cord-305263-fgwf6wy3	139	1	Thus	thus	RB
cord-305263-fgwf6wy3	139	2	as	as	IN
cord-305263-fgwf6wy3	139	3	for	for	IN
cord-305263-fgwf6wy3	139	4	the	the	DT
cord-305263-fgwf6wy3	139	5	SARS	SARS	NNP
cord-305263-fgwf6wy3	139	6	-	-	HYPH
cord-305263-fgwf6wy3	139	7	CoV	CoV	NNP
cord-305263-fgwf6wy3	139	8	,	,	,
cord-305263-fgwf6wy3	139	9	the	the	DT
cord-305263-fgwf6wy3	139	10	implications	implication	NNS
cord-305263-fgwf6wy3	139	11	are	be	VBP
cord-305263-fgwf6wy3	139	12	that	that	DT
cord-305263-fgwf6wy3	139	13	treatment	treatment	NN
cord-305263-fgwf6wy3	139	14	with	with	IN
cord-305263-fgwf6wy3	139	15	IFN	IFN	NNP
cord-305263-fgwf6wy3	139	16	-	-	:
cord-305263-fgwf6wy3	139	17	a	a	DT
cord-305263-fgwf6wy3	139	18	can	can	MD
cord-305263-fgwf6wy3	139	19	override	override	VB
cord-305263-fgwf6wy3	139	20	the	the	DT
cord-305263-fgwf6wy3	139	21	inhibitory	inhibitory	JJ
cord-305263-fgwf6wy3	139	22	effects	effect	NNS
cord-305263-fgwf6wy3	139	23	of	of	IN
cord-305263-fgwf6wy3	139	24	NS1	ns1	NN
cord-305263-fgwf6wy3	139	25	on	on	IN
cord-305263-fgwf6wy3	139	26	an	an	DT
cord-305263-fgwf6wy3	139	27	IFN	IFN	NNP
cord-305263-fgwf6wy3	139	28	response	response	NN
cord-305263-fgwf6wy3	139	29	during	during	IN
cord-305263-fgwf6wy3	139	30	influenza	influenza	NN
cord-305263-fgwf6wy3	139	31	A	a	DT
cord-305263-fgwf6wy3	139	32	virus	virus	NN
cord-305263-fgwf6wy3	139	33	infection	infection	NN
cord-305263-fgwf6wy3	139	34	.	.	.
cord-305263-fgwf6wy3	140	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	140	2	therapy	therapy	NN
cord-305263-fgwf6wy3	140	3	for	for	IN
cord-305263-fgwf6wy3	140	4	highly	highly	RB
cord-305263-fgwf6wy3	140	5	pathogenic	pathogenic	JJ
cord-305263-fgwf6wy3	140	6	and	and	CC
cord-305263-fgwf6wy3	140	7	oncogenic	oncogenic	JJ
cord-305263-fgwf6wy3	140	8	viral	viral	JJ
cord-305263-fgwf6wy3	140	9	infections	infection	NNS
cord-305263-fgwf6wy3	140	10	:	:	:
cord-305263-fgwf6wy3	140	11	HBV	HBV	NNP
cord-305263-fgwf6wy3	140	12	and	and	CC
cord-305263-fgwf6wy3	140	13	HCV	HCV	NNP
cord-305263-fgwf6wy3	140	14	Worldwide	Worldwide	NNP
cord-305263-fgwf6wy3	140	15	,	,	,
cord-305263-fgwf6wy3	140	16	>	>	XX
cord-305263-fgwf6wy3	141	1	170	170	CD
cord-305263-fgwf6wy3	141	2	million	million	CD
cord-305263-fgwf6wy3	141	3	people	people	NNS
cord-305263-fgwf6wy3	141	4	are	be	VBP
cord-305263-fgwf6wy3	141	5	infected	infect	VBN
cord-305263-fgwf6wy3	141	6	with	with	IN
cord-305263-fgwf6wy3	141	7	HCV	HCV	NNP
cord-305263-fgwf6wy3	141	8	,	,	,
cord-305263-fgwf6wy3	141	9	resulting	result	VBG
cord-305263-fgwf6wy3	141	10	in	in	IN
cord-305263-fgwf6wy3	141	11	approximately	approximately	RB
cord-305263-fgwf6wy3	141	12	350	350	CD
cord-305263-fgwf6wy3	141	13	000	000	CD
cord-305263-fgwf6wy3	141	14	deaths	death	NNS
cord-305263-fgwf6wy3	141	15	each	each	DT
cord-305263-fgwf6wy3	141	16	year	year	NN
cord-305263-fgwf6wy3	141	17	(	(	-LRB-
cord-305263-fgwf6wy3	141	18	http://www.who.int/mediacentre/factsheets/fs164/en/	http://www.who.int/mediacentre/factsheets/fs164/en/	NNP
cord-305263-fgwf6wy3	141	19	)	)	-RRB-
cord-305263-fgwf6wy3	141	20	.	.	.
cord-305263-fgwf6wy3	142	1	More	More	JJR
cord-305263-fgwf6wy3	142	2	than	than	IN
cord-305263-fgwf6wy3	142	3	an	an	DT
cord-305263-fgwf6wy3	142	4	estimated	estimate	VBN
cord-305263-fgwf6wy3	142	5	350	350	CD
cord-305263-fgwf6wy3	142	6	million	million	CD
cord-305263-fgwf6wy3	142	7	people	people	NNS
cord-305263-fgwf6wy3	142	8	are	be	VBP
cord-305263-fgwf6wy3	142	9	chronically	chronically	RB
cord-305263-fgwf6wy3	142	10	infected	infect	VBN
cord-305263-fgwf6wy3	142	11	with	with	IN
cord-305263-fgwf6wy3	142	12	HBV	HBV	NNP
cord-305263-fgwf6wy3	142	13	,	,	,
cord-305263-fgwf6wy3	142	14	resulting	result	VBG
cord-305263-fgwf6wy3	142	15	in	in	IN
cord-305263-fgwf6wy3	142	16	approximately	approximately	RB
cord-305263-fgwf6wy3	142	17	600	600	CD
cord-305263-fgwf6wy3	142	18	000	000	CD
cord-305263-fgwf6wy3	142	19	deaths	death	NNS
cord-305263-fgwf6wy3	142	20	each	each	DT
cord-305263-fgwf6wy3	142	21	year	year	NN
cord-305263-fgwf6wy3	142	22	(	(	-LRB-
cord-305263-fgwf6wy3	142	23	http://www.who.int/mediacentre/factsheets/fs204/en/	http://www.who.int/mediacentre/factsheets/fs204/en/	NNP
cord-305263-fgwf6wy3	142	24	)	)	-RRB-
cord-305263-fgwf6wy3	142	25	.	.	.
cord-305263-fgwf6wy3	143	1	HCV	HCV	NNP
cord-305263-fgwf6wy3	143	2	and	and	CC
cord-305263-fgwf6wy3	143	3	HBV	HBV	NNP
cord-305263-fgwf6wy3	143	4	target	target	VBP
cord-305263-fgwf6wy3	143	5	the	the	DT
cord-305263-fgwf6wy3	143	6	liver	liver	NN
cord-305263-fgwf6wy3	143	7	and	and	CC
cord-305263-fgwf6wy3	143	8	cause	cause	VB
cord-305263-fgwf6wy3	143	9	both	both	DT
cord-305263-fgwf6wy3	143	10	acute	acute	JJ
cord-305263-fgwf6wy3	143	11	and	and	CC
cord-305263-fgwf6wy3	143	12	chronic	chronic	JJ
cord-305263-fgwf6wy3	143	13	infections	infection	NNS
cord-305263-fgwf6wy3	143	14	,	,	,
cord-305263-fgwf6wy3	143	15	resulting	result	VBG
cord-305263-fgwf6wy3	143	16	in	in	IN
cord-305263-fgwf6wy3	143	17	liver	liver	NN
cord-305263-fgwf6wy3	143	18	cirrhosis	cirrhosis	NN
cord-305263-fgwf6wy3	143	19	and	and	CC
cord-305263-fgwf6wy3	143	20	eventually	eventually	RB
cord-305263-fgwf6wy3	143	21	,	,	,
cord-305263-fgwf6wy3	143	22	hepatocellular	hepatocellular	JJ
cord-305263-fgwf6wy3	143	23	carcinoma	carcinoma	NN
cord-305263-fgwf6wy3	143	24	[	[	-LRB-
cord-305263-fgwf6wy3	143	25	16	16	CD
cord-305263-fgwf6wy3	143	26	,	,	,
cord-305263-fgwf6wy3	143	27	53	53	CD
cord-305263-fgwf6wy3	143	28	]	]	-RRB-
cord-305263-fgwf6wy3	143	29	.	.	.
cord-305263-fgwf6wy3	144	1	The	the	DT
cord-305263-fgwf6wy3	144	2	current	current	JJ
cord-305263-fgwf6wy3	144	3	approved	approve	VBN
cord-305263-fgwf6wy3	144	4	standard	standard	NN
cord-305263-fgwf6wy3	144	5	-	-	HYPH
cord-305263-fgwf6wy3	144	6	of	of	IN
cord-305263-fgwf6wy3	144	7	-	-	HYPH
cord-305263-fgwf6wy3	144	8	care	care	NN
cord-305263-fgwf6wy3	144	9	treatment	treatment	NN
cord-305263-fgwf6wy3	144	10	for	for	IN
cord-305263-fgwf6wy3	144	11	HCV	HCV	NNP
cord-305263-fgwf6wy3	144	12	infection	infection	NN
cord-305263-fgwf6wy3	144	13	comprises	comprise	VBZ
cord-305263-fgwf6wy3	144	14	daily	daily	RB
cord-305263-fgwf6wy3	144	15	ribavirin	ribavirin	RB
cord-305263-fgwf6wy3	144	16	in	in	IN
cord-305263-fgwf6wy3	144	17	combination	combination	NN
cord-305263-fgwf6wy3	144	18	with	with	IN
cord-305263-fgwf6wy3	144	19	weekly	weekly	JJ
cord-305263-fgwf6wy3	144	20	pegylated	pegylate	VBN
cord-305263-fgwf6wy3	144	21	IFN	IFN	NNP
cord-305263-fgwf6wy3	144	22	-	-	HYPH
cord-305263-fgwf6wy3	144	23	a	a	DT
cord-305263-fgwf6wy3	144	24	(	(	-LRB-
cord-305263-fgwf6wy3	144	25	peg	peg	NN
cord-305263-fgwf6wy3	144	26	-	-	HYPH
cord-305263-fgwf6wy3	144	27	IFN	IFN	NNP
cord-305263-fgwf6wy3	144	28	-	-	HYPH
cord-305263-fgwf6wy3	144	29	a	a	NN
cord-305263-fgwf6wy3	144	30	)	)	-RRB-
cord-305263-fgwf6wy3	144	31	.	.	.
cord-305263-fgwf6wy3	145	1	The	the	DT
cord-305263-fgwf6wy3	145	2	covalent	covalent	JJ
cord-305263-fgwf6wy3	145	3	linkage	linkage	NN
cord-305263-fgwf6wy3	145	4	of	of	IN
cord-305263-fgwf6wy3	145	5	polyethylene	polyethylene	NN
cord-305263-fgwf6wy3	145	6	glycol	glycol	NN
cord-305263-fgwf6wy3	145	7	to	to	IN
cord-305263-fgwf6wy3	145	8	IFN	IFN	NNP
cord-305263-fgwf6wy3	145	9	-	-	:
cord-305263-fgwf6wy3	145	10	a	a	DT
cord-305263-fgwf6wy3	145	11	increases	increase	VBZ
cord-305263-fgwf6wy3	145	12	the	the	DT
cord-305263-fgwf6wy3	145	13	halflife	halflife	NN
cord-305263-fgwf6wy3	145	14	of	of	IN
cord-305263-fgwf6wy3	145	15	IFN	IFN	NNP
cord-305263-fgwf6wy3	145	16	-	-	:
cord-305263-fgwf6wy3	145	17	a	a	NN
cord-305263-fgwf6wy3	145	18	in	in	IN
cord-305263-fgwf6wy3	145	19	the	the	DT
cord-305263-fgwf6wy3	145	20	circulation	circulation	NN
cord-305263-fgwf6wy3	145	21	.	.	.
cord-305263-fgwf6wy3	146	1	Common	common	JJ
cord-305263-fgwf6wy3	146	2	side	side	NN
cord-305263-fgwf6wy3	146	3	effects	effect	NNS
cord-305263-fgwf6wy3	146	4	associated	associate	VBN
cord-305263-fgwf6wy3	146	5	with	with	IN
cord-305263-fgwf6wy3	146	6	IFN	IFN	NNP
cord-305263-fgwf6wy3	146	7	therapy	therapy	NN
cord-305263-fgwf6wy3	146	8	include	include	VBP
cord-305263-fgwf6wy3	146	9	a	a	DT
cord-305263-fgwf6wy3	146	10	range	range	NN
cord-305263-fgwf6wy3	146	11	of	of	IN
cord-305263-fgwf6wy3	146	12	flu	flu	NN
cord-305263-fgwf6wy3	146	13	-	-	HYPH
cord-305263-fgwf6wy3	146	14	like	like	JJ
cord-305263-fgwf6wy3	146	15	symptoms	symptom	NNS
cord-305263-fgwf6wy3	146	16	(	(	-LRB-
cord-305263-fgwf6wy3	146	17	fatigue	fatigue	NN
cord-305263-fgwf6wy3	146	18	,	,	,
cord-305263-fgwf6wy3	146	19	fever	fever	NN
cord-305263-fgwf6wy3	146	20	,	,	,
cord-305263-fgwf6wy3	146	21	myalgia	myalgia	NN
cord-305263-fgwf6wy3	146	22	)	)	-RRB-
cord-305263-fgwf6wy3	146	23	,	,	,
cord-305263-fgwf6wy3	146	24	that	that	WDT
cord-305263-fgwf6wy3	146	25	often	often	RB
cord-305263-fgwf6wy3	146	26	diminish	diminish	VBP
cord-305263-fgwf6wy3	146	27	spontaneously	spontaneously	RB
cord-305263-fgwf6wy3	146	28	during	during	IN
cord-305263-fgwf6wy3	146	29	the	the	DT
cord-305263-fgwf6wy3	146	30	first	first	JJ
cord-305263-fgwf6wy3	146	31	few	few	JJ
cord-305263-fgwf6wy3	146	32	weeks	week	NNS
cord-305263-fgwf6wy3	146	33	of	of	IN
cord-305263-fgwf6wy3	146	34	therapy	therapy	NN
cord-305263-fgwf6wy3	146	35	.	.	.
cord-305263-fgwf6wy3	147	1	More	more	RBR
cord-305263-fgwf6wy3	147	2	severe	severe	JJ
cord-305263-fgwf6wy3	147	3	neuropsychiatric	neuropsychiatric	JJ
cord-305263-fgwf6wy3	147	4	disturbances	disturbance	NNS
cord-305263-fgwf6wy3	147	5	including	include	VBG
cord-305263-fgwf6wy3	147	6	sleep	sleep	NN
cord-305263-fgwf6wy3	147	7	disturbances	disturbance	NNS
cord-305263-fgwf6wy3	147	8	and	and	CC
cord-305263-fgwf6wy3	147	9	depressive	depressive	JJ
cord-305263-fgwf6wy3	147	10	mood	mood	NN
cord-305263-fgwf6wy3	147	11	changes	change	NNS
cord-305263-fgwf6wy3	147	12	have	have	VBP
cord-305263-fgwf6wy3	147	13	their	-PRON-	PRP$
cord-305263-fgwf6wy3	147	14	onset	onset	NN
cord-305263-fgwf6wy3	147	15	within	within	IN
cord-305263-fgwf6wy3	147	16	the	the	DT
cord-305263-fgwf6wy3	147	17	first	first	JJ
cord-305263-fgwf6wy3	147	18	months	month	NNS
cord-305263-fgwf6wy3	147	19	of	of	IN
cord-305263-fgwf6wy3	147	20	IFN	IFN	NNP
cord-305263-fgwf6wy3	147	21	therapy	therapy	NN
cord-305263-fgwf6wy3	147	22	.	.	.
cord-305263-fgwf6wy3	148	1	Hematological	Hematological	NNP
cord-305263-fgwf6wy3	148	2	disturbances	disturbance	NNS
cord-305263-fgwf6wy3	148	3	such	such	JJ
cord-305263-fgwf6wy3	148	4	as	as	IN
cord-305263-fgwf6wy3	148	5	neutropenia	neutropenia	NN
cord-305263-fgwf6wy3	148	6	or	or	CC
cord-305263-fgwf6wy3	148	7	anemia	anemia	NN
cord-305263-fgwf6wy3	148	8	may	may	MD
cord-305263-fgwf6wy3	148	9	occur	occur	VB
cord-305263-fgwf6wy3	148	10	and	and	CC
cord-305263-fgwf6wy3	148	11	are	be	VBP
cord-305263-fgwf6wy3	148	12	responsive	responsive	JJ
cord-305263-fgwf6wy3	148	13	to	to	IN
cord-305263-fgwf6wy3	148	14	IFN	IFN	NNP
cord-305263-fgwf6wy3	148	15	dose	dose	JJ
cord-305263-fgwf6wy3	148	16	reduction	reduction	NN
cord-305263-fgwf6wy3	148	17	or	or	CC
cord-305263-fgwf6wy3	148	18	treatment	treatment	NN
cord-305263-fgwf6wy3	148	19	[	[	-LRB-
cord-305263-fgwf6wy3	148	20	granulocyte	granulocyte	NN
cord-305263-fgwf6wy3	148	21	colony	colony	NN
cord-305263-fgwf6wy3	148	22	-	-	HYPH
cord-305263-fgwf6wy3	148	23	stimulating	stimulate	VBG
cord-305263-fgwf6wy3	148	24	factor	factor	NN
cord-305263-fgwf6wy3	148	25	(	(	-LRB-
cord-305263-fgwf6wy3	148	26	G	G	NNP
cord-305263-fgwf6wy3	148	27	-	-	HYPH
cord-305263-fgwf6wy3	148	28	CSF	CSF	NNP
cord-305263-fgwf6wy3	148	29	)	)	-RRB-
cord-305263-fgwf6wy3	148	30	,	,	,
cord-305263-fgwf6wy3	148	31	erythropoietin	erythropoietin	NN
cord-305263-fgwf6wy3	148	32	(	(	-LRB-
cord-305263-fgwf6wy3	148	33	EPO	EPO	NNP
cord-305263-fgwf6wy3	148	34	)	)	-RRB-
cord-305263-fgwf6wy3	148	35	,	,	,
cord-305263-fgwf6wy3	148	36	respectively	respectively	RB
cord-305263-fgwf6wy3	148	37	]	]	-RRB-
cord-305263-fgwf6wy3	148	38	.	.	.
cord-305263-fgwf6wy3	149	1	This	this	DT
cord-305263-fgwf6wy3	149	2	combination	combination	NN
cord-305263-fgwf6wy3	149	3	IFN	IFN	NNP
cord-305263-fgwf6wy3	149	4	/	/	SYM
cord-305263-fgwf6wy3	149	5	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	149	6	therapy	therapy	NN
cord-305263-fgwf6wy3	149	7	has	have	VBZ
cord-305263-fgwf6wy3	149	8	been	be	VBN
cord-305263-fgwf6wy3	149	9	very	very	RB
cord-305263-fgwf6wy3	149	10	successful	successful	JJ
cord-305263-fgwf6wy3	149	11	in	in	IN
cord-305263-fgwf6wy3	149	12	patients	patient	NNS
cord-305263-fgwf6wy3	149	13	infected	infect	VBN
cord-305263-fgwf6wy3	149	14	with	with	IN
cord-305263-fgwf6wy3	149	15	HCV	HCV	NNP
cord-305263-fgwf6wy3	149	16	genotypes	genotype	NNS
cord-305263-fgwf6wy3	149	17	2	2	CD
cord-305263-fgwf6wy3	149	18	or	or	CC
cord-305263-fgwf6wy3	149	19	3	3	CD
cord-305263-fgwf6wy3	149	20	,	,	,
cord-305263-fgwf6wy3	149	21	and	and	CC
cord-305263-fgwf6wy3	149	22	70	70	CD
cord-305263-fgwf6wy3	149	23	-	-	SYM
cord-305263-fgwf6wy3	149	24	90	90	CD
cord-305263-fgwf6wy3	149	25	%	%	NN
cord-305263-fgwf6wy3	149	26	of	of	IN
cord-305263-fgwf6wy3	149	27	patients	patient	NNS
cord-305263-fgwf6wy3	149	28	go	go	VB
cord-305263-fgwf6wy3	149	29	on	on	RP
cord-305263-fgwf6wy3	149	30	to	to	TO
cord-305263-fgwf6wy3	149	31	achieve	achieve	VB
cord-305263-fgwf6wy3	149	32	an	an	DT
cord-305263-fgwf6wy3	149	33	SVR	SVR	NNP
cord-305263-fgwf6wy3	149	34	,	,	,
cord-305263-fgwf6wy3	149	35	characterized	characterize	VBN
cord-305263-fgwf6wy3	149	36	by	by	IN
cord-305263-fgwf6wy3	149	37	undetectable	undetectable	JJ
cord-305263-fgwf6wy3	149	38	HCV	HCV	NNP
cord-305263-fgwf6wy3	149	39	RNA	RNA	NNP
cord-305263-fgwf6wy3	149	40	following	follow	VBG
cord-305263-fgwf6wy3	149	41	24	24	CD
cord-305263-fgwf6wy3	149	42	weeks	week	NNS
cord-305263-fgwf6wy3	149	43	of	of	IN
cord-305263-fgwf6wy3	149	44	treatment	treatment	NN
cord-305263-fgwf6wy3	149	45	[	[	-LRB-
cord-305263-fgwf6wy3	149	46	53	53	CD
cord-305263-fgwf6wy3	149	47	]	]	-RRB-
cord-305263-fgwf6wy3	149	48	.	.	.
cord-305263-fgwf6wy3	150	1	The	the	DT
cord-305263-fgwf6wy3	150	2	rate	rate	NN
cord-305263-fgwf6wy3	150	3	of	of	IN
cord-305263-fgwf6wy3	150	4	SVR	SVR	NNP
cord-305263-fgwf6wy3	150	5	falls	fall	VBZ
cord-305263-fgwf6wy3	150	6	to	to	IN
cord-305263-fgwf6wy3	150	7	40	40	CD
cord-305263-fgwf6wy3	150	8	-	-	SYM
cord-305263-fgwf6wy3	150	9	60	60	CD
cord-305263-fgwf6wy3	150	10	%	%	NN
cord-305263-fgwf6wy3	150	11	in	in	IN
cord-305263-fgwf6wy3	150	12	patients	patient	NNS
cord-305263-fgwf6wy3	150	13	infected	infect	VBN
cord-305263-fgwf6wy3	150	14	with	with	IN
cord-305263-fgwf6wy3	150	15	HCV	HCV	NNP
cord-305263-fgwf6wy3	150	16	genotypes	genotype	NNS
cord-305263-fgwf6wy3	150	17	1	1	CD
cord-305263-fgwf6wy3	150	18	or	or	CC
cord-305263-fgwf6wy3	150	19	4	4	CD
cord-305263-fgwf6wy3	150	20	,	,	,
cord-305263-fgwf6wy3	150	21	Trends	Trends	NNPS
cord-305263-fgwf6wy3	150	22	in	in	IN
cord-305263-fgwf6wy3	150	23	Immunology	Immunology	NNP
cord-305263-fgwf6wy3	150	24	April	April	NNP
cord-305263-fgwf6wy3	150	25	2012	2012	CD
cord-305263-fgwf6wy3	150	26	,	,	,
cord-305263-fgwf6wy3	150	27	Vol	Vol	NNP
cord-305263-fgwf6wy3	150	28	.	.	.
cord-305263-fgwf6wy3	151	1	33	33	CD
cord-305263-fgwf6wy3	151	2	,	,	,
cord-305263-fgwf6wy3	151	3	No	no	NN
cord-305263-fgwf6wy3	151	4	.	.	NN
cord-305263-fgwf6wy3	151	5	4	4	CD
cord-305263-fgwf6wy3	151	6	following	follow	VBG
cord-305263-fgwf6wy3	151	7	48	48	CD
cord-305263-fgwf6wy3	151	8	weeks	week	NNS
cord-305263-fgwf6wy3	151	9	of	of	IN
cord-305263-fgwf6wy3	151	10	treatment	treatment	NN
cord-305263-fgwf6wy3	151	11	with	with	IN
cord-305263-fgwf6wy3	151	12	peg	peg	NN
cord-305263-fgwf6wy3	151	13	-	-	HYPH
cord-305263-fgwf6wy3	151	14	IFN	IFN	NNP
cord-305263-fgwf6wy3	151	15	-	-	HYPH
cord-305263-fgwf6wy3	151	16	a	a	NN
cord-305263-fgwf6wy3	151	17	and	and	CC
cord-305263-fgwf6wy3	151	18	ribavirin	ribavirin	JJ
cord-305263-fgwf6wy3	151	19	[	[	-LRB-
cord-305263-fgwf6wy3	151	20	53	53	CD
cord-305263-fgwf6wy3	151	21	]	]	-RRB-
cord-305263-fgwf6wy3	151	22	.	.	.
cord-305263-fgwf6wy3	152	1	The	the	DT
cord-305263-fgwf6wy3	152	2	incomplete	incomplete	JJ
cord-305263-fgwf6wy3	152	3	response	response	NN
cord-305263-fgwf6wy3	152	4	to	to	IN
cord-305263-fgwf6wy3	152	5	IFN	IFN	NNP
cord-305263-fgwf6wy3	152	6	treatment	treatment	NN
cord-305263-fgwf6wy3	152	7	is	be	VBZ
cord-305263-fgwf6wy3	152	8	partially	partially	RB
cord-305263-fgwf6wy3	152	9	attributable	attributable	JJ
cord-305263-fgwf6wy3	152	10	to	to	IN
cord-305263-fgwf6wy3	152	11	virally	virally	RB
cord-305263-fgwf6wy3	152	12	encoded	encode	VBN
cord-305263-fgwf6wy3	152	13	virulence	virulence	NN
cord-305263-fgwf6wy3	152	14	factors	factor	NNS
cord-305263-fgwf6wy3	152	15	that	that	WDT
cord-305263-fgwf6wy3	152	16	interfere	interfere	VBP
cord-305263-fgwf6wy3	152	17	with	with	IN
cord-305263-fgwf6wy3	152	18	an	an	DT
cord-305263-fgwf6wy3	152	19	IFN	IFN	NNP
cord-305263-fgwf6wy3	152	20	response	response	NN
cord-305263-fgwf6wy3	152	21	:	:	:
cord-305263-fgwf6wy3	152	22	NS3/4A	ns3/4a	NN
cord-305263-fgwf6wy3	152	23	and	and	CC
cord-305263-fgwf6wy3	152	24	NS5A.	NS5A.	NNP
cord-305263-fgwf6wy3	152	25	NS3/4A	ns3/4a	NN
cord-305263-fgwf6wy3	152	26	is	be	VBZ
cord-305263-fgwf6wy3	152	27	an	an	DT
cord-305263-fgwf6wy3	152	28	HCV	HCV	NNP
cord-305263-fgwf6wy3	152	29	serine	serine	NN
cord-305263-fgwf6wy3	152	30	protease	protease	NN
cord-305263-fgwf6wy3	152	31	that	that	WDT
cord-305263-fgwf6wy3	152	32	targets	target	VBZ
cord-305263-fgwf6wy3	152	33	mitochondrial	mitochondrial	JJ
cord-305263-fgwf6wy3	152	34	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	152	35	signaling	signaling	NN
cord-305263-fgwf6wy3	152	36	(	(	-LRB-
cord-305263-fgwf6wy3	152	37	MAVS	MAVS	NNP
cord-305263-fgwf6wy3	152	38	)	)	-RRB-
cord-305263-fgwf6wy3	152	39	proteins	protein	NNS
cord-305263-fgwf6wy3	152	40	required	require	VBN
cord-305263-fgwf6wy3	152	41	for	for	IN
cord-305263-fgwf6wy3	152	42	RIG	rig	NN
cord-305263-fgwf6wy3	152	43	-	-	HYPH
cord-305263-fgwf6wy3	152	44	I	i	NN
cord-305263-fgwf6wy3	152	45	-	-	HYPH
cord-305263-fgwf6wy3	152	46	mediated	mediate	VBN
cord-305263-fgwf6wy3	152	47	IRF3	IRF3	NNP
cord-305263-fgwf6wy3	152	48	activation	activation	NN
cord-305263-fgwf6wy3	152	49	and	and	CC
cord-305263-fgwf6wy3	152	50	subsequent	subsequent	JJ
cord-305263-fgwf6wy3	152	51	IFN	IFN	NNP
cord-305263-fgwf6wy3	152	52	production	production	NN
cord-305263-fgwf6wy3	152	53	[	[	-LRB-
cord-305263-fgwf6wy3	152	54	16	16	CD
cord-305263-fgwf6wy3	152	55	]	]	-RRB-
cord-305263-fgwf6wy3	152	56	.	.	.
cord-305263-fgwf6wy3	153	1	Recently	recently	RB
cord-305263-fgwf6wy3	153	2	,	,	,
cord-305263-fgwf6wy3	153	3	the	the	DT
cord-305263-fgwf6wy3	153	4	secondary	secondary	JJ
cord-305263-fgwf6wy3	153	5	structure	structure	NN
cord-305263-fgwf6wy3	153	6	of	of	IN
cord-305263-fgwf6wy3	153	7	the	the	DT
cord-305263-fgwf6wy3	153	8	HCV	HCV	NNP
cord-305263-fgwf6wy3	153	9	genotype	genotype	NN
cord-305263-fgwf6wy3	153	10	1b	1b	CD
cord-305263-fgwf6wy3	153	11	NS3	NS3	NNP
cord-305263-fgwf6wy3	153	12	N	n	CD
cord-305263-fgwf6wy3	153	13	-	-	HYPH
cord-305263-fgwf6wy3	153	14	terminal	terminal	NN
cord-305263-fgwf6wy3	153	15	region	region	NN
cord-305263-fgwf6wy3	153	16	was	be	VBD
cord-305263-fgwf6wy3	153	17	identified	identify	VBN
cord-305263-fgwf6wy3	153	18	as	as	IN
cord-305263-fgwf6wy3	153	19	a	a	DT
cord-305263-fgwf6wy3	153	20	predictive	predictive	JJ
cord-305263-fgwf6wy3	153	21	marker	marker	NN
cord-305263-fgwf6wy3	153	22	for	for	IN
cord-305263-fgwf6wy3	153	23	the	the	DT
cord-305263-fgwf6wy3	153	24	virological	virological	JJ
cord-305263-fgwf6wy3	153	25	response	response	NN
cord-305263-fgwf6wy3	153	26	in	in	IN
cord-305263-fgwf6wy3	153	27	patients	patient	NNS
cord-305263-fgwf6wy3	153	28	who	who	WP
cord-305263-fgwf6wy3	153	29	had	have	VBD
cord-305263-fgwf6wy3	153	30	received	receive	VBN
cord-305263-fgwf6wy3	153	31	IFN	IFN	NNP
cord-305263-fgwf6wy3	153	32	and	and	CC
cord-305263-fgwf6wy3	153	33	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	153	34	combination	combination	NN
cord-305263-fgwf6wy3	153	35	therapy	therapy	NN
cord-305263-fgwf6wy3	153	36	for	for	IN
cord-305263-fgwf6wy3	153	37	48	48	CD
cord-305263-fgwf6wy3	153	38	weeks	week	NNS
cord-305263-fgwf6wy3	153	39	.	.	.
cord-305263-fgwf6wy3	154	1	Specifically	specifically	RB
cord-305263-fgwf6wy3	154	2	,	,	,
cord-305263-fgwf6wy3	154	3	polymorphisms	polymorphism	NNS
cord-305263-fgwf6wy3	154	4	in	in	IN
cord-305263-fgwf6wy3	154	5	the	the	DT
cord-305263-fgwf6wy3	154	6	secondary	secondary	JJ
cord-305263-fgwf6wy3	154	7	structure	structure	NN
cord-305263-fgwf6wy3	154	8	of	of	IN
cord-305263-fgwf6wy3	154	9	the	the	DT
cord-305263-fgwf6wy3	154	10	NS3	NS3	NNP
cord-305263-fgwf6wy3	154	11	amino	amino	NN
cord-305263-fgwf6wy3	154	12	-	-	HYPH
cord-305263-fgwf6wy3	154	13	terminal	terminal	NN
cord-305263-fgwf6wy3	154	14	region	region	NN
cord-305263-fgwf6wy3	154	15	segregate	segregate	VBP
cord-305263-fgwf6wy3	154	16	HCV	HCV	NNP
cord-305263-fgwf6wy3	154	17	genotype	genotype	NN
cord-305263-fgwf6wy3	154	18	1b	1b	CD
cord-305263-fgwf6wy3	154	19	infected	infect	VBN
cord-305263-fgwf6wy3	154	20	individuals	individual	NNS
cord-305263-fgwf6wy3	154	21	into	into	IN
cord-305263-fgwf6wy3	154	22	two	two	CD
cord-305263-fgwf6wy3	154	23	groups	group	NNS
cord-305263-fgwf6wy3	154	24	and	and	CC
cord-305263-fgwf6wy3	154	25	are	be	VBP
cord-305263-fgwf6wy3	154	26	predictive	predictive	JJ
cord-305263-fgwf6wy3	154	27	of	of	IN
cord-305263-fgwf6wy3	154	28	the	the	DT
cord-305263-fgwf6wy3	154	29	virological	virological	JJ
cord-305263-fgwf6wy3	154	30	response	response	NN
cord-305263-fgwf6wy3	154	31	to	to	IN
cord-305263-fgwf6wy3	154	32	peg	peg	NN
cord-305263-fgwf6wy3	154	33	-	-	:
cord-305263-fgwf6wy3	154	34	IFN	IFN	NNP
cord-305263-fgwf6wy3	154	35	plus	plus	CC
cord-305263-fgwf6wy3	154	36	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	154	37	therapy	therapy	NN
cord-305263-fgwf6wy3	154	38	[	[	-LRB-
cord-305263-fgwf6wy3	154	39	54	54	CD
cord-305263-fgwf6wy3	154	40	]	]	-RRB-
cord-305263-fgwf6wy3	154	41	.	.	.
cord-305263-fgwf6wy3	155	1	NS5A	NS5A	NNP
cord-305263-fgwf6wy3	156	1	associates	associate	NNS
cord-305263-fgwf6wy3	156	2	with	with	IN
cord-305263-fgwf6wy3	156	3	intracellular	intracellular	JJ
cord-305263-fgwf6wy3	156	4	membranes	membrane	NNS
cord-305263-fgwf6wy3	156	5	and	and	CC
cord-305263-fgwf6wy3	156	6	its	-PRON-	PRP$
cord-305263-fgwf6wy3	156	7	expression	expression	NN
cord-305263-fgwf6wy3	156	8	is	be	VBZ
cord-305263-fgwf6wy3	156	9	vital	vital	JJ
cord-305263-fgwf6wy3	156	10	for	for	IN
cord-305263-fgwf6wy3	156	11	HCV	HCV	NNP
cord-305263-fgwf6wy3	156	12	genome	genome	NN
cord-305263-fgwf6wy3	156	13	replication	replication	NN
cord-305263-fgwf6wy3	156	14	.	.	.
cord-305263-fgwf6wy3	157	1	NS5A	NS5A	NNP
cord-305263-fgwf6wy3	157	2	is	be	VBZ
cord-305263-fgwf6wy3	157	3	able	able	JJ
cord-305263-fgwf6wy3	157	4	to	to	TO
cord-305263-fgwf6wy3	157	5	interact	interact	VB
cord-305263-fgwf6wy3	157	6	with	with	IN
cord-305263-fgwf6wy3	157	7	IFN	IFN	NNP
cord-305263-fgwf6wy3	157	8	-	-	HYPH
cord-305263-fgwf6wy3	157	9	inducible	inducible	JJ
cord-305263-fgwf6wy3	157	10	PKR	PKR	NNP
cord-305263-fgwf6wy3	157	11	to	to	TO
cord-305263-fgwf6wy3	157	12	evade	evade	VB
cord-305263-fgwf6wy3	157	13	an	an	DT
cord-305263-fgwf6wy3	157	14	IFN	IFN	NNP
cord-305263-fgwf6wy3	157	15	-	-	HYPH
cord-305263-fgwf6wy3	157	16	induced	induce	VBN
cord-305263-fgwf6wy3	157	17	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	157	18	response	response	NN
cord-305263-fgwf6wy3	157	19	.	.	.
cord-305263-fgwf6wy3	158	1	Polymorphisms	polymorphism	NNS
cord-305263-fgwf6wy3	158	2	in	in	IN
cord-305263-fgwf6wy3	158	3	amino	amino	NN
cord-305263-fgwf6wy3	158	4	acid	acid	NN
cord-305263-fgwf6wy3	158	5	residues	residue	NNS
cord-305263-fgwf6wy3	158	6	70	70	CD
cord-305263-fgwf6wy3	158	7	and	and	CC
cord-305263-fgwf6wy3	158	8	91	91	CD
cord-305263-fgwf6wy3	158	9	in	in	IN
cord-305263-fgwf6wy3	158	10	the	the	DT
cord-305263-fgwf6wy3	158	11	HCV	HCV	NNP
cord-305263-fgwf6wy3	158	12	core	core	NN
cord-305263-fgwf6wy3	158	13	and	and	CC
cord-305263-fgwf6wy3	158	14	in	in	IN
cord-305263-fgwf6wy3	158	15	NS5A	NS5A	NNS
cord-305263-fgwf6wy3	158	16	are	be	VBP
cord-305263-fgwf6wy3	158	17	also	also	RB
cord-305263-fgwf6wy3	158	18	predictive	predictive	JJ
cord-305263-fgwf6wy3	158	19	markers	marker	NNS
cord-305263-fgwf6wy3	158	20	of	of	IN
cord-305263-fgwf6wy3	158	21	the	the	DT
cord-305263-fgwf6wy3	158	22	virological	virological	JJ
cord-305263-fgwf6wy3	158	23	response	response	NN
cord-305263-fgwf6wy3	158	24	in	in	IN
cord-305263-fgwf6wy3	158	25	patients	patient	NNS
cord-305263-fgwf6wy3	158	26	receiving	receive	VBG
cord-305263-fgwf6wy3	158	27	IFN	IFN	NNP
cord-305263-fgwf6wy3	158	28	and	and	CC
cord-305263-fgwf6wy3	158	29	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	158	30	therapy	therapy	NN
cord-305263-fgwf6wy3	158	31	[	[	-LRB-
cord-305263-fgwf6wy3	158	32	55	55	CD
cord-305263-fgwf6wy3	158	33	]	]	-RRB-
cord-305263-fgwf6wy3	158	34	.	.	.
cord-305263-fgwf6wy3	159	1	Notably	notably	RB
cord-305263-fgwf6wy3	159	2	,	,	,
cord-305263-fgwf6wy3	159	3	NS5A	NS5A	NNP
cord-305263-fgwf6wy3	159	4	is	be	VBZ
cord-305263-fgwf6wy3	159	5	a	a	DT
cord-305263-fgwf6wy3	159	6	target	target	NN
cord-305263-fgwf6wy3	159	7	of	of	IN
cord-305263-fgwf6wy3	159	8	IFN	IFN	NNP
cord-305263-fgwf6wy3	159	9	,	,	,
cord-305263-fgwf6wy3	159	10	because	because	IN
cord-305263-fgwf6wy3	159	11	the	the	DT
cord-305263-fgwf6wy3	159	12	IFN	IFN	NNP
cord-305263-fgwf6wy3	159	13	-	-	HYPH
cord-305263-fgwf6wy3	159	14	activated	activate	VBN
cord-305263-fgwf6wy3	159	15	gene	gene	NN
cord-305263-fgwf6wy3	159	16	15	15	CD
cord-305263-fgwf6wy3	159	17	(	(	-LRB-
cord-305263-fgwf6wy3	159	18	IFI15)/interferon	IFI15)/interferon	NNP
cord-305263-fgwf6wy3	159	19	stimulated	stimulate	VBN
cord-305263-fgwf6wy3	159	20	gene	gene	NN
cord-305263-fgwf6wy3	159	21	(	(	-LRB-
cord-305263-fgwf6wy3	159	22	ISG15	isg15	NN
cord-305263-fgwf6wy3	159	23	)	)	-RRB-
cord-305263-fgwf6wy3	159	24	encoding	encode	VBG
cord-305263-fgwf6wy3	159	25	a	a	DT
cord-305263-fgwf6wy3	159	26	17-kDa	17-kda	CD
cord-305263-fgwf6wy3	159	27	protein	protein	NN
cord-305263-fgwf6wy3	159	28	,	,	,
cord-305263-fgwf6wy3	159	29	promotes	promote	VBZ
cord-305263-fgwf6wy3	159	30	ISGylation	isgylation	NN
cord-305263-fgwf6wy3	159	31	of	of	IN
cord-305263-fgwf6wy3	159	32	NS5A	NS5A	NNP
cord-305263-fgwf6wy3	159	33	to	to	TO
cord-305263-fgwf6wy3	159	34	enhance	enhance	VB
cord-305263-fgwf6wy3	159	35	its	-PRON-	PRP$
cord-305263-fgwf6wy3	159	36	degradation	degradation	NN
cord-305263-fgwf6wy3	159	37	,	,	,
cord-305263-fgwf6wy3	159	38	thereby	thereby	RB
cord-305263-fgwf6wy3	159	39	inhibiting	inhibit	VBG
cord-305263-fgwf6wy3	159	40	HCV	HCV	NNP
cord-305263-fgwf6wy3	159	41	replication	replication	NN
cord-305263-fgwf6wy3	159	42	[	[	-LRB-
cord-305263-fgwf6wy3	159	43	56	56	CD
cord-305263-fgwf6wy3	159	44	]	]	-RRB-
cord-305263-fgwf6wy3	159	45	.	.	.
cord-305263-fgwf6wy3	160	1	In	in	IN
cord-305263-fgwf6wy3	160	2	addition	addition	NN
cord-305263-fgwf6wy3	160	3	to	to	IN
cord-305263-fgwf6wy3	160	4	HCV	HCV	NNP
cord-305263-fgwf6wy3	160	5	NS5A	NS5A	NNP
cord-305263-fgwf6wy3	160	6	,	,	,
cord-305263-fgwf6wy3	160	7	both	both	CC
cord-305263-fgwf6wy3	160	8	the	the	DT
cord-305263-fgwf6wy3	160	9	HCV	HCV	NNP
cord-305263-fgwf6wy3	160	10	envelope	envelope	NN
cord-305263-fgwf6wy3	160	11	protein	protein	NN
cord-305263-fgwf6wy3	160	12	E2	E2	NNP
cord-305263-fgwf6wy3	160	13	and	and	CC
cord-305263-fgwf6wy3	160	14	the	the	DT
cord-305263-fgwf6wy3	160	15	internal	internal	JJ
cord-305263-fgwf6wy3	160	16	ribosome	ribosome	NN
cord-305263-fgwf6wy3	160	17	entry	entry	NN
cord-305263-fgwf6wy3	160	18	site	site	NN
cord-305263-fgwf6wy3	160	19	(	(	-LRB-
cord-305263-fgwf6wy3	160	20	IRES	IRES	NNP
cord-305263-fgwf6wy3	160	21	)	)	-RRB-
cord-305263-fgwf6wy3	160	22	are	be	VBP
cord-305263-fgwf6wy3	160	23	able	able	JJ
cord-305263-fgwf6wy3	160	24	to	to	TO
cord-305263-fgwf6wy3	160	25	inhibit	inhibit	VB
cord-305263-fgwf6wy3	160	26	IFN	IFN	NNP
cord-305263-fgwf6wy3	160	27	-	-	HYPH
cord-305263-fgwf6wy3	160	28	inducible	inducible	JJ
cord-305263-fgwf6wy3	160	29	PKR	PKR	NNP
cord-305263-fgwf6wy3	160	30	activity	activity	NN
cord-305263-fgwf6wy3	160	31	[	[	-LRB-
cord-305263-fgwf6wy3	160	32	57	57	CD
cord-305263-fgwf6wy3	160	33	]	]	-RRB-
cord-305263-fgwf6wy3	160	34	.	.	.
cord-305263-fgwf6wy3	161	1	E2	E2	NNP
cord-305263-fgwf6wy3	161	2	contains	contain	VBZ
cord-305263-fgwf6wy3	161	3	a	a	DT
cord-305263-fgwf6wy3	161	4	eukaryotic	eukaryotic	JJ
cord-305263-fgwf6wy3	161	5	translation	translation	NN
cord-305263-fgwf6wy3	161	6	initiation	initiation	NN
cord-305263-fgwf6wy3	161	7	factor	factor	NN
cord-305263-fgwf6wy3	161	8	2	2	CD
cord-305263-fgwf6wy3	161	9	(	(	-LRB-
cord-305263-fgwf6wy3	161	10	eIF-2a	eif-2a	NN
cord-305263-fgwf6wy3	161	11	)	)	-RRB-
cord-305263-fgwf6wy3	162	1	phosphorylation	phosphorylation	NN
cord-305263-fgwf6wy3	162	2	homology	homology	NN
cord-305263-fgwf6wy3	162	3	domain	domain	NN
cord-305263-fgwf6wy3	162	4	through	through	IN
cord-305263-fgwf6wy3	162	5	which	which	WDT
cord-305263-fgwf6wy3	162	6	it	-PRON-	PRP
cord-305263-fgwf6wy3	162	7	is	be	VBZ
cord-305263-fgwf6wy3	162	8	able	able	JJ
cord-305263-fgwf6wy3	162	9	to	to	TO
cord-305263-fgwf6wy3	162	10	interact	interact	VB
cord-305263-fgwf6wy3	162	11	with	with	IN
cord-305263-fgwf6wy3	162	12	PKR	PKR	NNP
cord-305263-fgwf6wy3	162	13	,	,	,
cord-305263-fgwf6wy3	162	14	whereas	whereas	IN
cord-305263-fgwf6wy3	162	15	the	the	DT
cord-305263-fgwf6wy3	162	16	HCV	HCV	NNP
cord-305263-fgwf6wy3	162	17	IRES	IRES	NNP
cord-305263-fgwf6wy3	162	18	binds	bind	VBZ
cord-305263-fgwf6wy3	162	19	to	to	IN
cord-305263-fgwf6wy3	162	20	PKR	PKR	NNP
cord-305263-fgwf6wy3	162	21	,	,	,
cord-305263-fgwf6wy3	162	22	precluding	preclude	VBG
cord-305263-fgwf6wy3	162	23	dsRNA	dsrna	NN
cord-305263-fgwf6wy3	162	24	binding	binding	NN
cord-305263-fgwf6wy3	162	25	,	,	,
cord-305263-fgwf6wy3	162	26	thereby	thereby	RB
cord-305263-fgwf6wy3	162	27	preventing	prevent	VBG
cord-305263-fgwf6wy3	162	28	PKR	PKR	NNP
cord-305263-fgwf6wy3	162	29	activation	activation	NN
cord-305263-fgwf6wy3	162	30	[	[	-LRB-
cord-305263-fgwf6wy3	162	31	57	57	CD
cord-305263-fgwf6wy3	162	32	]	]	-RRB-
cord-305263-fgwf6wy3	162	33	.	.	.
cord-305263-fgwf6wy3	163	1	Despite	despite	IN
cord-305263-fgwf6wy3	163	2	these	these	DT
cord-305263-fgwf6wy3	163	3	potent	potent	JJ
cord-305263-fgwf6wy3	163	4	inhibitory	inhibitory	JJ
cord-305263-fgwf6wy3	163	5	effects	effect	NNS
cord-305263-fgwf6wy3	163	6	of	of	IN
cord-305263-fgwf6wy3	163	7	HCV	HCV	NNP
cord-305263-fgwf6wy3	163	8	-	-	HYPH
cord-305263-fgwf6wy3	163	9	encoded	encode	VBN
cord-305263-fgwf6wy3	163	10	factors	factor	NNS
cord-305263-fgwf6wy3	163	11	on	on	IN
cord-305263-fgwf6wy3	163	12	an	an	DT
cord-305263-fgwf6wy3	163	13	IFN	IFN	NNP
cord-305263-fgwf6wy3	163	14	response	response	NN
cord-305263-fgwf6wy3	163	15	,	,	,
cord-305263-fgwf6wy3	163	16	clinical	clinical	JJ
cord-305263-fgwf6wy3	163	17	data	datum	NNS
cord-305263-fgwf6wy3	163	18	provide	provide	VBP
cord-305263-fgwf6wy3	163	19	direct	direct	JJ
cord-305263-fgwf6wy3	163	20	evidence	evidence	NN
cord-305263-fgwf6wy3	163	21	that	that	IN
cord-305263-fgwf6wy3	163	22	peg	peg	NN
cord-305263-fgwf6wy3	163	23	-	-	HYPH
cord-305263-fgwf6wy3	163	24	IFN	IFN	NNP
cord-305263-fgwf6wy3	163	25	-	-	:
cord-305263-fgwf6wy3	163	26	a	a	DT
cord-305263-fgwf6wy3	163	27	treatment	treatment	NN
cord-305263-fgwf6wy3	163	28	in	in	IN
cord-305263-fgwf6wy3	163	29	combination	combination	NN
cord-305263-fgwf6wy3	163	30	with	with	IN
cord-305263-fgwf6wy3	163	31	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	163	32	is	be	VBZ
cord-305263-fgwf6wy3	163	33	effective	effective	JJ
cord-305263-fgwf6wy3	163	34	at	at	IN
cord-305263-fgwf6wy3	163	35	limiting	limit	VBG
cord-305263-fgwf6wy3	163	36	HCV	HCV	NNP
cord-305263-fgwf6wy3	163	37	infection	infection	NN
cord-305263-fgwf6wy3	163	38	and	and	CC
cord-305263-fgwf6wy3	163	39	,	,	,
cord-305263-fgwf6wy3	163	40	dependent	dependent	JJ
cord-305263-fgwf6wy3	163	41	on	on	IN
cord-305263-fgwf6wy3	163	42	the	the	DT
cord-305263-fgwf6wy3	163	43	HCV	HCV	NNP
cord-305263-fgwf6wy3	163	44	genotype	genotype	NN
cord-305263-fgwf6wy3	163	45	,	,	,
cord-305263-fgwf6wy3	163	46	may	may	MD
cord-305263-fgwf6wy3	163	47	invoke	invoke	VB
cord-305263-fgwf6wy3	163	48	a	a	DT
cord-305263-fgwf6wy3	163	49	SVR	svr	NN
cord-305263-fgwf6wy3	163	50	.	.	.
cord-305263-fgwf6wy3	164	1	The	the	DT
cord-305263-fgwf6wy3	164	2	mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	164	3	by	by	IN
cord-305263-fgwf6wy3	164	4	which	which	WDT
cord-305263-fgwf6wy3	164	5	HBV	HBV	NNP
cord-305263-fgwf6wy3	164	6	evades	evade	VBZ
cord-305263-fgwf6wy3	164	7	an	an	DT
cord-305263-fgwf6wy3	164	8	innate	innate	JJ
cord-305263-fgwf6wy3	164	9	immune	immune	JJ
cord-305263-fgwf6wy3	164	10	response	response	NN
cord-305263-fgwf6wy3	164	11	are	be	VBP
cord-305263-fgwf6wy3	164	12	less	less	RBR
cord-305263-fgwf6wy3	164	13	well	well	RB
cord-305263-fgwf6wy3	164	14	understood	understand	VBN
cord-305263-fgwf6wy3	164	15	.	.	.
cord-305263-fgwf6wy3	165	1	The	the	DT
cord-305263-fgwf6wy3	165	2	HBV	HBV	NNP
cord-305263-fgwf6wy3	165	3	polymerase	polymerase	NN
cord-305263-fgwf6wy3	165	4	(	(	-LRB-
cord-305263-fgwf6wy3	165	5	Pol	Pol	NNP
cord-305263-fgwf6wy3	165	6	)	)	-RRB-
cord-305263-fgwf6wy3	165	7	blocks	block	VBZ
cord-305263-fgwf6wy3	166	1	IRF	IRF	NNP
cord-305263-fgwf6wy3	166	2	signaling	signal	VBG
cord-305263-fgwf6wy3	166	3	and	and	CC
cord-305263-fgwf6wy3	166	4	subsequent	subsequent	JJ
cord-305263-fgwf6wy3	166	5	IFN	IFN	NNP
cord-305263-fgwf6wy3	166	6	production	production	NN
cord-305263-fgwf6wy3	166	7	by	by	IN
cord-305263-fgwf6wy3	166	8	inhibiting	inhibit	VBG
cord-305263-fgwf6wy3	166	9	TBK1	TBK1	NNP
cord-305263-fgwf6wy3	166	10	/	/	SYM
cord-305263-fgwf6wy3	166	11	IKKe	IKKe	NNP
cord-305263-fgwf6wy3	166	12	activity	activity	NN
cord-305263-fgwf6wy3	166	13	,	,	,
cord-305263-fgwf6wy3	166	14	associated	associate	VBN
cord-305263-fgwf6wy3	166	15	with	with	IN
cord-305263-fgwf6wy3	166	16	PRR	PRR	NNP
cord-305263-fgwf6wy3	166	17	signaling	signal	VBG
cord-305263-fgwf6wy3	166	18	[	[	-LRB-
cord-305263-fgwf6wy3	166	19	17	17	CD
cord-305263-fgwf6wy3	166	20	]	]	-RRB-
cord-305263-fgwf6wy3	166	21	.	.	.
cord-305263-fgwf6wy3	167	1	This	this	DT
cord-305263-fgwf6wy3	167	2	inhibition	inhibition	NN
cord-305263-fgwf6wy3	167	3	is	be	VBZ
cord-305263-fgwf6wy3	167	4	mediated	mediate	VBN
cord-305263-fgwf6wy3	167	5	by	by	IN
cord-305263-fgwf6wy3	167	6	direct	direct	JJ
cord-305263-fgwf6wy3	167	7	protein	protein	NN
cord-305263-fgwf6wy3	167	8	-	-	HYPH
cord-305263-fgwf6wy3	167	9	protein	protein	NN
cord-305263-fgwf6wy3	167	10	interactions	interaction	NNS
cord-305263-fgwf6wy3	167	11	between	between	IN
cord-305263-fgwf6wy3	167	12	Pol	Pol	NNP
cord-305263-fgwf6wy3	167	13	and	and	CC
cord-305263-fgwf6wy3	167	14	the	the	DT
cord-305263-fgwf6wy3	167	15	host	host	NN
cord-305263-fgwf6wy3	167	16	DEAD	DEAD	NNP
cord-305263-fgwf6wy3	167	17	box	box	NN
cord-305263-fgwf6wy3	168	1	(	(	-LRB-
cord-305263-fgwf6wy3	168	2	D	d	NN
cord-305263-fgwf6wy3	168	3	-	-	HYPH
cord-305263-fgwf6wy3	168	4	E	e	JJ
cord-305263-fgwf6wy3	168	5	-	-	HYPH
cord-305263-fgwf6wy3	168	6	A	a	NN
cord-305263-fgwf6wy3	168	7	-	-	HYPH
cord-305263-fgwf6wy3	168	8	D	d	NN
cord-305263-fgwf6wy3	168	9	amino	amino	NN
cord-305263-fgwf6wy3	168	10	acid	acid	NN
cord-305263-fgwf6wy3	168	11	sequence	sequence	NN
cord-305263-fgwf6wy3	168	12	motif	motif	NN
cord-305263-fgwf6wy3	168	13	)	)	-RRB-
cord-305263-fgwf6wy3	169	1	RNA	RNA	NNP
cord-305263-fgwf6wy3	169	2	helicase	helicase	NNP
cord-305263-fgwf6wy3	169	3	,	,	,
cord-305263-fgwf6wy3	169	4	DDX3	DDX3	NNP
cord-305263-fgwf6wy3	169	5	,	,	,
cord-305263-fgwf6wy3	169	6	that	that	DT
cord-305263-fgwf6wy3	169	7	enhances	enhance	VBZ
cord-305263-fgwf6wy3	169	8	TBK1	TBK1	NNP
cord-305263-fgwf6wy3	169	9	/	/	SYM
cord-305263-fgwf6wy3	169	10	IKKe	IKKe	NNS
cord-305263-fgwf6wy3	169	11	activity	activity	NN
cord-305263-fgwf6wy3	169	12	[	[	-LRB-
cord-305263-fgwf6wy3	169	13	17	17	CD
cord-305263-fgwf6wy3	169	14	]	]	-RRB-
cord-305263-fgwf6wy3	169	15	.	.	.
cord-305263-fgwf6wy3	170	1	Peg	Peg	NNP
cord-305263-fgwf6wy3	170	2	-	-	HYPH
cord-305263-fgwf6wy3	170	3	IFN	IFN	NNP
cord-305263-fgwf6wy3	170	4	-	-	HYPH
cord-305263-fgwf6wy3	170	5	a	a	NNP
cord-305263-fgwf6wy3	170	6	is	be	VBZ
cord-305263-fgwf6wy3	170	7	an	an	DT
cord-305263-fgwf6wy3	170	8	effective	effective	JJ
cord-305263-fgwf6wy3	170	9	treatment	treatment	NN
cord-305263-fgwf6wy3	170	10	for	for	IN
cord-305263-fgwf6wy3	170	11	HBV	HBV	NNP
cord-305263-fgwf6wy3	170	12	infection	infection	NN
cord-305263-fgwf6wy3	170	13	,	,	,
cord-305263-fgwf6wy3	170	14	again	again	RB
cord-305263-fgwf6wy3	170	15	suggesting	suggest	VBG
cord-305263-fgwf6wy3	170	16	that	that	IN
cord-305263-fgwf6wy3	170	17	IFN	IFN	NNP
cord-305263-fgwf6wy3	170	18	treatment	treatment	NN
cord-305263-fgwf6wy3	170	19	can	can	MD
cord-305263-fgwf6wy3	170	20	overcome	overcome	VB
cord-305263-fgwf6wy3	170	21	virus	virus	NN
cord-305263-fgwf6wy3	170	22	-	-	HYPH
cord-305263-fgwf6wy3	170	23	imposed	impose	VBN
cord-305263-fgwf6wy3	170	24	inhibition	inhibition	NN
cord-305263-fgwf6wy3	170	25	of	of	IN
cord-305263-fgwf6wy3	170	26	the	the	DT
cord-305263-fgwf6wy3	170	27	innate	innate	JJ
cord-305263-fgwf6wy3	170	28	immune	immune	JJ
cord-305263-fgwf6wy3	170	29	response	response	NN
cord-305263-fgwf6wy3	170	30	,	,	,
cord-305263-fgwf6wy3	170	31	specifically	specifically	RB
cord-305263-fgwf6wy3	170	32	IFN	IFN	NNP
cord-305263-fgwf6wy3	170	33	production	production	NN
cord-305263-fgwf6wy3	170	34	.	.	.
cord-305263-fgwf6wy3	171	1	Peg	Peg	NNP
cord-305263-fgwf6wy3	171	2	-	-	HYPH
cord-305263-fgwf6wy3	171	3	IFN	IFN	NNP
cord-305263-fgwf6wy3	171	4	-	-	HYPH
cord-305263-fgwf6wy3	171	5	a	a	NNP
cord-305263-fgwf6wy3	171	6	is	be	VBZ
cord-305263-fgwf6wy3	171	7	an	an	DT
cord-305263-fgwf6wy3	171	8	effective	effective	JJ
cord-305263-fgwf6wy3	171	9	treatment	treatment	NN
cord-305263-fgwf6wy3	171	10	option	option	NN
cord-305263-fgwf6wy3	171	11	for	for	IN
cord-305263-fgwf6wy3	171	12	hepatitis	hepatitis	NNP
cord-305263-fgwf6wy3	171	13	B	B	NNP
cord-305263-fgwf6wy3	171	14	e	e	NN
cord-305263-fgwf6wy3	171	15	core	core	NN
cord-305263-fgwf6wy3	171	16	antigen	antigen	NN
cord-305263-fgwf6wy3	171	17	(	(	-LRB-
cord-305263-fgwf6wy3	171	18	HBeAg)positive	HBeAg)positive	NNP
cord-305263-fgwf6wy3	171	19	disease	disease	NN
cord-305263-fgwf6wy3	171	20	,	,	,
cord-305263-fgwf6wy3	171	21	where	where	WRB
cord-305263-fgwf6wy3	171	22	detection	detection	NN
cord-305263-fgwf6wy3	171	23	of	of	IN
cord-305263-fgwf6wy3	171	24	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	171	25	in	in	IN
cord-305263-fgwf6wy3	171	26	the	the	DT
cord-305263-fgwf6wy3	171	27	blood	blood	NN
cord-305263-fgwf6wy3	171	28	is	be	VBZ
cord-305263-fgwf6wy3	171	29	indicative	indicative	JJ
cord-305263-fgwf6wy3	171	30	of	of	IN
cord-305263-fgwf6wy3	171	31	viral	viral	JJ
cord-305263-fgwf6wy3	171	32	replication	replication	NN
cord-305263-fgwf6wy3	171	33	.	.	.
cord-305263-fgwf6wy3	172	1	Up	up	IN
cord-305263-fgwf6wy3	172	2	to	to	TO
cord-305263-fgwf6wy3	172	3	40	40	CD
cord-305263-fgwf6wy3	172	4	%	%	NN
cord-305263-fgwf6wy3	172	5	of	of	IN
cord-305263-fgwf6wy3	172	6	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	172	7	-	-	HYPH
cord-305263-fgwf6wy3	172	8	positive	positive	JJ
cord-305263-fgwf6wy3	172	9	patients	patient	NNS
cord-305263-fgwf6wy3	172	10	treated	treat	VBN
cord-305263-fgwf6wy3	172	11	with	with	IN
cord-305263-fgwf6wy3	172	12	peg	peg	NN
cord-305263-fgwf6wy3	172	13	-	-	HYPH
cord-305263-fgwf6wy3	172	14	IFN	IFN	NNP
cord-305263-fgwf6wy3	172	15	-	-	HYPH
cord-305263-fgwf6wy3	172	16	a	a	NNP
cord-305263-fgwf6wy3	172	17	are	be	VBP
cord-305263-fgwf6wy3	172	18	able	able	JJ
cord-305263-fgwf6wy3	172	19	to	to	TO
cord-305263-fgwf6wy3	172	20	develop	develop	VB
cord-305263-fgwf6wy3	172	21	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	172	22	-	-	HYPH
cord-305263-fgwf6wy3	172	23	specific	specific	JJ
cord-305263-fgwf6wy3	172	24	antibodies	antibody	NNS
cord-305263-fgwf6wy3	172	25	(	(	-LRB-
cord-305263-fgwf6wy3	172	26	seroconversion	seroconversion	NN
cord-305263-fgwf6wy3	172	27	)	)	-RRB-
cord-305263-fgwf6wy3	172	28	by	by	IN
cord-305263-fgwf6wy3	172	29	6	6	CD
cord-305263-fgwf6wy3	172	30	months	month	NNS
cord-305263-fgwf6wy3	172	31	after	after	IN
cord-305263-fgwf6wy3	172	32	the	the	DT
cord-305263-fgwf6wy3	172	33	end	end	NN
cord-305263-fgwf6wy3	172	34	of	of	IN
cord-305263-fgwf6wy3	172	35	treatment	treatment	NN
cord-305263-fgwf6wy3	172	36	.	.	.
cord-305263-fgwf6wy3	173	1	This	this	DT
cord-305263-fgwf6wy3	173	2	percentage	percentage	NN
cord-305263-fgwf6wy3	173	3	rises	rise	VBZ
cord-305263-fgwf6wy3	173	4	to	to	IN
cord-305263-fgwf6wy3	173	5	60	60	CD
cord-305263-fgwf6wy3	173	6	%	%	NN
cord-305263-fgwf6wy3	173	7	at	at	IN
cord-305263-fgwf6wy3	173	8	5	5	CD
cord-305263-fgwf6wy3	173	9	years	year	NNS
cord-305263-fgwf6wy3	173	10	after	after	IN
cord-305263-fgwf6wy3	173	11	the	the	DT
cord-305263-fgwf6wy3	173	12	end	end	NN
cord-305263-fgwf6wy3	173	13	of	of	IN
cord-305263-fgwf6wy3	173	14	treatment	treatment	NN
cord-305263-fgwf6wy3	173	15	[	[	-LRB-
cord-305263-fgwf6wy3	173	16	58	58	CD
cord-305263-fgwf6wy3	173	17	]	]	-RRB-
cord-305263-fgwf6wy3	173	18	.	.	.
cord-305263-fgwf6wy3	174	1	In	in	IN
cord-305263-fgwf6wy3	174	2	comparison	comparison	NN
cord-305263-fgwf6wy3	174	3	to	to	IN
cord-305263-fgwf6wy3	174	4	monotherapy	monotherapy	NN
cord-305263-fgwf6wy3	174	5	with	with	IN
cord-305263-fgwf6wy3	174	6	the	the	DT
cord-305263-fgwf6wy3	174	7	DAA	DAA	NNP
cord-305263-fgwf6wy3	174	8	lamivudine	lamivudine	NN
cord-305263-fgwf6wy3	174	9	,	,	,
cord-305263-fgwf6wy3	174	10	which	which	WDT
cord-305263-fgwf6wy3	174	11	can	can	MD
cord-305263-fgwf6wy3	174	12	lead	lead	VB
cord-305263-fgwf6wy3	174	13	to	to	IN
cord-305263-fgwf6wy3	174	14	the	the	DT
cord-305263-fgwf6wy3	174	15	emergence	emergence	NN
cord-305263-fgwf6wy3	174	16	of	of	IN
cord-305263-fgwf6wy3	174	17	mutant	mutant	JJ
cord-305263-fgwf6wy3	174	18	lamivudine	lamivudine	JJ
cord-305263-fgwf6wy3	174	19	-	-	HYPH
cord-305263-fgwf6wy3	174	20	resistant	resistant	JJ
cord-305263-fgwf6wy3	174	21	HBV	HBV	NNP
cord-305263-fgwf6wy3	174	22	strains	strain	NNS
cord-305263-fgwf6wy3	174	23	,	,	,
cord-305263-fgwf6wy3	174	24	peg	peg	NN
cord-305263-fgwf6wy3	174	25	-	-	HYPH
cord-305263-fgwf6wy3	174	26	IFN	IFN	NNP
cord-305263-fgwf6wy3	174	27	-	-	:
cord-305263-fgwf6wy3	174	28	a	a	DT
cord-305263-fgwf6wy3	174	29	alone	alone	JJ
cord-305263-fgwf6wy3	174	30	or	or	CC
cord-305263-fgwf6wy3	174	31	in	in	IN
cord-305263-fgwf6wy3	174	32	combination	combination	NN
cord-305263-fgwf6wy3	174	33	with	with	IN
cord-305263-fgwf6wy3	174	34	lamivudine	lamivudine	NNP
cord-305263-fgwf6wy3	174	35	is	be	VBZ
cord-305263-fgwf6wy3	174	36	up	up	IN
cord-305263-fgwf6wy3	174	37	to	to	TO
cord-305263-fgwf6wy3	174	38	50	50	CD
cord-305263-fgwf6wy3	174	39	%	%	NN
cord-305263-fgwf6wy3	174	40	more	more	JJR
cord-305263-fgwf6wy3	174	41	effective	effective	JJ
cord-305263-fgwf6wy3	174	42	for	for	IN
cord-305263-fgwf6wy3	174	43	inducing	induce	VBG
cord-305263-fgwf6wy3	174	44	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	174	45	seroconversion	seroconversion	NN
cord-305263-fgwf6wy3	174	46	,	,	,
cord-305263-fgwf6wy3	174	47	although	although	IN
cord-305263-fgwf6wy3	174	48	more	more	JJR
cord-305263-fgwf6wy3	174	49	side	side	NN
cord-305263-fgwf6wy3	174	50	effects	effect	NNS
cord-305263-fgwf6wy3	174	51	are	be	VBP
cord-305263-fgwf6wy3	174	52	reported	report	VBN
cord-305263-fgwf6wy3	174	53	in	in	IN
cord-305263-fgwf6wy3	174	54	patients	patient	NNS
cord-305263-fgwf6wy3	174	55	receiving	receive	VBG
cord-305263-fgwf6wy3	174	56	peg	peg	NN
cord-305263-fgwf6wy3	174	57	-	-	HYPH
cord-305263-fgwf6wy3	174	58	IFN	IFN	NNP
cord-305263-fgwf6wy3	174	59	-	-	HYPH
cord-305263-fgwf6wy3	174	60	a	a	DT
cord-305263-fgwf6wy3	174	61	[	[	-LRB-
cord-305263-fgwf6wy3	174	62	59	59	CD
cord-305263-fgwf6wy3	174	63	]	]	-RRB-
cord-305263-fgwf6wy3	174	64	.	.	.
cord-305263-fgwf6wy3	175	1	In	in	IN
cord-305263-fgwf6wy3	175	2	contrast	contrast	NN
cord-305263-fgwf6wy3	175	3	to	to	IN
cord-305263-fgwf6wy3	175	4	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	175	5	-	-	HYPH
cord-305263-fgwf6wy3	175	6	positive	positive	JJ
cord-305263-fgwf6wy3	175	7	disease	disease	NN
cord-305263-fgwf6wy3	175	8	,	,	,
cord-305263-fgwf6wy3	175	9	peg	peg	NN
cord-305263-fgwf6wy3	175	10	-	-	HYPH
cord-305263-fgwf6wy3	175	11	IFN	IFN	NNP
cord-305263-fgwf6wy3	175	12	-	-	HYPH
cord-305263-fgwf6wy3	175	13	a	a	NNP
cord-305263-fgwf6wy3	175	14	,	,	,
cord-305263-fgwf6wy3	175	15	alone	alone	JJ
cord-305263-fgwf6wy3	175	16	or	or	CC
cord-305263-fgwf6wy3	175	17	in	in	IN
cord-305263-fgwf6wy3	175	18	combination	combination	NN
cord-305263-fgwf6wy3	175	19	with	with	IN
cord-305263-fgwf6wy3	175	20	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	175	21	,	,	,
cord-305263-fgwf6wy3	175	22	has	have	VBZ
cord-305263-fgwf6wy3	175	23	limited	limit	VBN
cord-305263-fgwf6wy3	175	24	effect	effect	NN
cord-305263-fgwf6wy3	175	25	in	in	IN
cord-305263-fgwf6wy3	175	26	patients	patient	NNS
cord-305263-fgwf6wy3	175	27	with	with	IN
cord-305263-fgwf6wy3	175	28	late	late	JJ
cord-305263-fgwf6wy3	175	29	stage	stage	NN
cord-305263-fgwf6wy3	175	30	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	175	31	-	-	HYPH
cord-305263-fgwf6wy3	175	32	negative	negative	JJ
cord-305263-fgwf6wy3	175	33	disease	disease	NN
cord-305263-fgwf6wy3	175	34	,	,	,
cord-305263-fgwf6wy3	175	35	where	where	WRB
cord-305263-fgwf6wy3	175	36	the	the	DT
cord-305263-fgwf6wy3	175	37	HBV	HBV	NNP
cord-305263-fgwf6wy3	175	38	mutation	mutation	NN
cord-305263-fgwf6wy3	175	39	has	have	VBZ
cord-305263-fgwf6wy3	175	40	resulted	result	VBN
cord-305263-fgwf6wy3	175	41	in	in	IN
cord-305263-fgwf6wy3	175	42	loss	loss	NN
cord-305263-fgwf6wy3	175	43	of	of	IN
cord-305263-fgwf6wy3	175	44	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	175	45	expression	expression	NN
cord-305263-fgwf6wy3	175	46	[	[	-LRB-
cord-305263-fgwf6wy3	175	47	60	60	CD
cord-305263-fgwf6wy3	175	48	]	]	-RRB-
cord-305263-fgwf6wy3	175	49	.	.	.
cord-305263-fgwf6wy3	176	1	In	in	IN
cord-305263-fgwf6wy3	176	2	a	a	DT
cord-305263-fgwf6wy3	176	3	randomized	randomized	JJ
cord-305263-fgwf6wy3	176	4	clinical	clinical	JJ
cord-305263-fgwf6wy3	176	5	trial	trial	NN
cord-305263-fgwf6wy3	176	6	,	,	,
cord-305263-fgwf6wy3	176	7	the	the	DT
cord-305263-fgwf6wy3	176	8	percentage	percentage	NN
cord-305263-fgwf6wy3	176	9	of	of	IN
cord-305263-fgwf6wy3	176	10	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	176	11	-	-	HYPH
cord-305263-fgwf6wy3	176	12	negative	negative	JJ
cord-305263-fgwf6wy3	176	13	patients	patient	NNS
cord-305263-fgwf6wy3	176	14	with	with	IN
cord-305263-fgwf6wy3	176	15	HBV	HBV	NNP
cord-305263-fgwf6wy3	176	16	DNA	DNA	NNP
cord-305263-fgwf6wy3	176	17	levels	level	NNS
cord-305263-fgwf6wy3	176	18	<	<	XX
cord-305263-fgwf6wy3	176	19	10	10	CD
cord-305263-fgwf6wy3	176	20	000	000	CD
cord-305263-fgwf6wy3	176	21	copies	copy	NNS
cord-305263-fgwf6wy3	176	22	/	/	SYM
cord-305263-fgwf6wy3	176	23	ml	ml	NN
cord-305263-fgwf6wy3	176	24	,	,	,
cord-305263-fgwf6wy3	176	25	receiving	receive	VBG
cord-305263-fgwf6wy3	176	26	peg	peg	NN
cord-305263-fgwf6wy3	176	27	-	-	HYPH
cord-305263-fgwf6wy3	176	28	IFN	IFN	NNP
cord-305263-fgwf6wy3	176	29	-	-	HYPH
cord-305263-fgwf6wy3	176	30	a	a	NN
cord-305263-fgwf6wy3	176	31	monotherapy	monotherapy	NN
cord-305263-fgwf6wy3	176	32	,	,	,
cord-305263-fgwf6wy3	176	33	dropped	drop	VBD
cord-305263-fgwf6wy3	176	34	from	from	IN
cord-305263-fgwf6wy3	176	35	36	36	CD
cord-305263-fgwf6wy3	176	36	%	%	NN
cord-305263-fgwf6wy3	176	37	to	to	TO
cord-305263-fgwf6wy3	176	38	20	20	CD
cord-305263-fgwf6wy3	176	39	%	%	NN
cord-305263-fgwf6wy3	176	40	,	,	,
cord-305263-fgwf6wy3	176	41	from	from	IN
cord-305263-fgwf6wy3	176	42	the	the	DT
cord-305263-fgwf6wy3	176	43	end	end	NN
cord-305263-fgwf6wy3	176	44	of	of	IN
cord-305263-fgwf6wy3	176	45	treatment	treatment	NN
cord-305263-fgwf6wy3	176	46	to	to	IN
cord-305263-fgwf6wy3	176	47	24	24	CD
cord-305263-fgwf6wy3	176	48	weeks	week	NNS
cord-305263-fgwf6wy3	176	49	later	later	RB
cord-305263-fgwf6wy3	176	50	[	[	-LRB-
cord-305263-fgwf6wy3	176	51	60	60	CD
cord-305263-fgwf6wy3	176	52	]	]	-RRB-
cord-305263-fgwf6wy3	176	53	.	.	.
cord-305263-fgwf6wy3	177	1	The	the	DT
cord-305263-fgwf6wy3	177	2	stage	stage	NN
cord-305263-fgwf6wy3	177	3	of	of	IN
cord-305263-fgwf6wy3	177	4	viral	viral	JJ
cord-305263-fgwf6wy3	177	5	disease	disease	NN
cord-305263-fgwf6wy3	177	6	can	can	MD
cord-305263-fgwf6wy3	177	7	therefore	therefore	RB
cord-305263-fgwf6wy3	177	8	affect	affect	VB
cord-305263-fgwf6wy3	177	9	the	the	DT
cord-305263-fgwf6wy3	177	10	efficacy	efficacy	NN
cord-305263-fgwf6wy3	177	11	of	of	IN
cord-305263-fgwf6wy3	177	12	IFN	IFN	NNP
cord-305263-fgwf6wy3	177	13	therapy	therapy	NN
cord-305263-fgwf6wy3	177	14	and	and	CC
cord-305263-fgwf6wy3	177	15	the	the	DT
cord-305263-fgwf6wy3	177	16	timing	timing	NN
cord-305263-fgwf6wy3	177	17	of	of	IN
cord-305263-fgwf6wy3	177	18	treatment	treatment	NN
cord-305263-fgwf6wy3	177	19	contributes	contribute	VBZ
cord-305263-fgwf6wy3	177	20	to	to	IN
cord-305263-fgwf6wy3	177	21	the	the	DT
cord-305263-fgwf6wy3	177	22	capacity	capacity	NN
cord-305263-fgwf6wy3	177	23	to	to	TO
cord-305263-fgwf6wy3	177	24	resolve	resolve	VB
cord-305263-fgwf6wy3	177	25	an	an	DT
cord-305263-fgwf6wy3	177	26	infection	infection	NN
cord-305263-fgwf6wy3	177	27	.	.	.
cord-305263-fgwf6wy3	178	1	Moreover	moreover	RB
cord-305263-fgwf6wy3	178	2	,	,	,
cord-305263-fgwf6wy3	178	3	as	as	IN
cord-305263-fgwf6wy3	178	4	for	for	IN
cord-305263-fgwf6wy3	178	5	influenza	influenza	NN
cord-305263-fgwf6wy3	178	6	viruses	virus	NNS
cord-305263-fgwf6wy3	178	7	and	and	CC
cord-305263-fgwf6wy3	178	8	SARS	SARS	NNP
cord-305263-fgwf6wy3	178	9	-	-	HYPH
cord-305263-fgwf6wy3	178	10	CoV	CoV	NNP
cord-305263-fgwf6wy3	178	11	,	,	,
cord-305263-fgwf6wy3	178	12	despite	despite	IN
cord-305263-fgwf6wy3	178	13	HBV	HBV	NNP
cord-305263-fgwf6wy3	178	14	and	and	CC
cord-305263-fgwf6wy3	178	15	HCV	HCV	NNP
cord-305263-fgwf6wy3	178	16	encoding	encode	VBG
cord-305263-fgwf6wy3	178	17	viral	viral	JJ
cord-305263-fgwf6wy3	178	18	factors	factor	NNS
cord-305263-fgwf6wy3	178	19	that	that	WDT
cord-305263-fgwf6wy3	178	20	antagonize	antagonize	VBP
cord-305263-fgwf6wy3	178	21	an	an	DT
cord-305263-fgwf6wy3	178	22	IFN	IFN	NNP
cord-305263-fgwf6wy3	178	23	response	response	NN
cord-305263-fgwf6wy3	178	24	,	,	,
cord-305263-fgwf6wy3	178	25	exogenous	exogenous	JJ
cord-305263-fgwf6wy3	178	26	IFN	IFN	NNP
cord-305263-fgwf6wy3	178	27	therapy	therapy	NN
cord-305263-fgwf6wy3	178	28	has	have	VBZ
cord-305263-fgwf6wy3	178	29	proven	prove	VBN
cord-305263-fgwf6wy3	178	30	to	to	TO
cord-305263-fgwf6wy3	178	31	be	be	VB
cord-305263-fgwf6wy3	178	32	an	an	DT
cord-305263-fgwf6wy3	178	33	effective	effective	JJ
cord-305263-fgwf6wy3	178	34	treatment	treatment	NN
cord-305263-fgwf6wy3	178	35	for	for	IN
cord-305263-fgwf6wy3	178	36	establishing	establish	VBG
cord-305263-fgwf6wy3	178	37	an	an	DT
cord-305263-fgwf6wy3	178	38	SVR	SVR	NNP
cord-305263-fgwf6wy3	178	39	.	.	.
cord-305263-fgwf6wy3	179	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	179	2	therapy	therapy	NN
cord-305263-fgwf6wy3	179	3	for	for	IN
cord-305263-fgwf6wy3	179	4	highly	highly	RB
cord-305263-fgwf6wy3	179	5	transmissible	transmissible	JJ
cord-305263-fgwf6wy3	179	6	viral	viral	JJ
cord-305263-fgwf6wy3	179	7	infections	infection	NNS
cord-305263-fgwf6wy3	179	8	:	:	:
cord-305263-fgwf6wy3	180	1	HSV-1	hsv-1	NN
cord-305263-fgwf6wy3	180	2	HSV-1	hsv-1	NN
cord-305263-fgwf6wy3	180	3	is	be	VBZ
cord-305263-fgwf6wy3	180	4	a	a	DT
cord-305263-fgwf6wy3	180	5	highly	highly	RB
cord-305263-fgwf6wy3	180	6	contagious	contagious	JJ
cord-305263-fgwf6wy3	180	7	virus	virus	NN
cord-305263-fgwf6wy3	180	8	,	,	,
cord-305263-fgwf6wy3	180	9	prevalent	prevalent	JJ
cord-305263-fgwf6wy3	180	10	among	among	IN
cord-305263-fgwf6wy3	180	11	sexually	sexually	RB
cord-305263-fgwf6wy3	180	12	transmitted	transmit	VBN
cord-305263-fgwf6wy3	180	13	infections	infection	NNS
cord-305263-fgwf6wy3	180	14	.	.	.
cord-305263-fgwf6wy3	181	1	HSV-1	hsv-1	NN
cord-305263-fgwf6wy3	181	2	is	be	VBZ
cord-305263-fgwf6wy3	181	3	able	able	JJ
cord-305263-fgwf6wy3	181	4	to	to	TO
cord-305263-fgwf6wy3	181	5	establish	establish	VB
cord-305263-fgwf6wy3	181	6	a	a	DT
cord-305263-fgwf6wy3	181	7	latent	latent	JJ
cord-305263-fgwf6wy3	181	8	infection	infection	NN
cord-305263-fgwf6wy3	181	9	in	in	IN
cord-305263-fgwf6wy3	181	10	immunocompetent	immunocompetent	JJ
cord-305263-fgwf6wy3	181	11	individuals	individual	NNS
cord-305263-fgwf6wy3	181	12	by	by	IN
cord-305263-fgwf6wy3	181	13	evading	evade	VBG
cord-305263-fgwf6wy3	181	14	the	the	DT
cord-305263-fgwf6wy3	181	15	immune	immune	JJ
cord-305263-fgwf6wy3	181	16	system	system	NN
cord-305263-fgwf6wy3	181	17	and	and	CC
cord-305263-fgwf6wy3	181	18	is	be	VBZ
cord-305263-fgwf6wy3	181	19	only	only	RB
cord-305263-fgwf6wy3	181	20	reactivated	reactivate	VBN
cord-305263-fgwf6wy3	181	21	when	when	WRB
cord-305263-fgwf6wy3	181	22	the	the	DT
cord-305263-fgwf6wy3	181	23	host	host	NN
cord-305263-fgwf6wy3	181	24	immune	immune	JJ
cord-305263-fgwf6wy3	181	25	system	system	NN
cord-305263-fgwf6wy3	181	26	is	be	VBZ
cord-305263-fgwf6wy3	181	27	weakened	weaken	VBN
cord-305263-fgwf6wy3	181	28	[	[	-LRB-
cord-305263-fgwf6wy3	181	29	61	61	CD
cord-305263-fgwf6wy3	181	30	,	,	,
cord-305263-fgwf6wy3	181	31	62	62	CD
cord-305263-fgwf6wy3	181	32	]	]	-RRB-
cord-305263-fgwf6wy3	181	33	.	.	.
cord-305263-fgwf6wy3	182	1	The	the	DT
cord-305263-fgwf6wy3	182	2	HSV-1	HSV-1	NNP
cord-305263-fgwf6wy3	182	3	genome	genome	NN
cord-305263-fgwf6wy3	182	4	encodes	encode	VBZ
cord-305263-fgwf6wy3	182	5	a	a	DT
cord-305263-fgwf6wy3	182	6	number	number	NN
cord-305263-fgwf6wy3	182	7	of	of	IN
cord-305263-fgwf6wy3	182	8	virulence	virulence	NN
cord-305263-fgwf6wy3	182	9	factors	factor	NNS
cord-305263-fgwf6wy3	182	10	,	,	,
cord-305263-fgwf6wy3	182	11	namely	namely	RB
cord-305263-fgwf6wy3	182	12	infected	infected	JJ
cord-305263-fgwf6wy3	182	13	cell	cell	NN
cord-305263-fgwf6wy3	182	14	protein	protein	NN
cord-305263-fgwf6wy3	182	15	(	(	-LRB-
cord-305263-fgwf6wy3	182	16	ICP	ICP	NNP
cord-305263-fgwf6wy3	182	17	)	)	-RRB-
cord-305263-fgwf6wy3	182	18	34.5	34.5	CD
cord-305263-fgwf6wy3	182	19	,	,	,
cord-305263-fgwf6wy3	182	20	ICP0	ICP0	NNP
cord-305263-fgwf6wy3	182	21	and	and	CC
cord-305263-fgwf6wy3	182	22	ICP27	ICP27	NNP
cord-305263-fgwf6wy3	182	23	,	,	,
cord-305263-fgwf6wy3	182	24	which	which	WDT
cord-305263-fgwf6wy3	182	25	are	be	VBP
cord-305263-fgwf6wy3	182	26	associated	associate	VBN
cord-305263-fgwf6wy3	182	27	with	with	IN
cord-305263-fgwf6wy3	182	28	immunoevasion	immunoevasion	NN
cord-305263-fgwf6wy3	182	29	and	and	CC
cord-305263-fgwf6wy3	182	30	suppression	suppression	NN
cord-305263-fgwf6wy3	182	31	of	of	IN
cord-305263-fgwf6wy3	182	32	the	the	DT
cord-305263-fgwf6wy3	182	33	innate	innate	JJ
cord-305263-fgwf6wy3	182	34	immune	immune	JJ
cord-305263-fgwf6wy3	182	35	response	response	NN
cord-305263-fgwf6wy3	182	36	to	to	IN
cord-305263-fgwf6wy3	182	37	virus	virus	NN
cord-305263-fgwf6wy3	182	38	infection	infection	NN
cord-305263-fgwf6wy3	182	39	[	[	-LRB-
cord-305263-fgwf6wy3	182	40	18	18	CD
cord-305263-fgwf6wy3	182	41	,	,	,
cord-305263-fgwf6wy3	182	42	21	21	CD
cord-305263-fgwf6wy3	182	43	,	,	,
cord-305263-fgwf6wy3	182	44	63	63	CD
cord-305263-fgwf6wy3	182	45	,	,	,
cord-305263-fgwf6wy3	182	46	64	64	CD
cord-305263-fgwf6wy3	182	47	]	]	-RRB-
cord-305263-fgwf6wy3	182	48	.	.	.
cord-305263-fgwf6wy3	183	1	Specifically	specifically	RB
cord-305263-fgwf6wy3	183	2	,	,	,
cord-305263-fgwf6wy3	183	3	ICP34.5	ICP34.5	NNP
cord-305263-fgwf6wy3	183	4	dephosphorylates	dephosphorylate	VBZ
cord-305263-fgwf6wy3	183	5	eIF-2a	eif-2a	XX
cord-305263-fgwf6wy3	184	1	to	to	TO
cord-305263-fgwf6wy3	184	2	reverse	reverse	VB
cord-305263-fgwf6wy3	184	3	PKR	PKR	NNP
cord-305263-fgwf6wy3	184	4	-	-	HYPH
cord-305263-fgwf6wy3	184	5	mediated	mediate	VBN
cord-305263-fgwf6wy3	184	6	inactivation	inactivation	NN
cord-305263-fgwf6wy3	184	7	of	of	IN
cord-305263-fgwf6wy3	184	8	eIF-2a	eif-2a	NN
cord-305263-fgwf6wy3	184	9	[	[	-LRB-
cord-305263-fgwf6wy3	184	10	63	63	CD
cord-305263-fgwf6wy3	184	11	]	]	-RRB-
cord-305263-fgwf6wy3	184	12	,	,	,
cord-305263-fgwf6wy3	184	13	ICP0	ICP0	NNP
cord-305263-fgwf6wy3	184	14	localizes	localize	VBZ
cord-305263-fgwf6wy3	184	15	to	to	IN
cord-305263-fgwf6wy3	184	16	the	the	DT
cord-305263-fgwf6wy3	184	17	cytoplasm	cytoplasm	NN
cord-305263-fgwf6wy3	184	18	and	and	CC
cord-305263-fgwf6wy3	184	19	inhibits	inhibit	VBZ
cord-305263-fgwf6wy3	184	20	IRF3	IRF3	NNP
cord-305263-fgwf6wy3	184	21	activity	activity	NN
cord-305263-fgwf6wy3	184	22	[	[	-LRB-
cord-305263-fgwf6wy3	184	23	18	18	CD
cord-305263-fgwf6wy3	184	24	]	]	-RRB-
cord-305263-fgwf6wy3	184	25	,	,	,
cord-305263-fgwf6wy3	184	26	and	and	CC
cord-305263-fgwf6wy3	184	27	ICP27	ICP27	NNP
cord-305263-fgwf6wy3	184	28	blunts	blunt	VBZ
cord-305263-fgwf6wy3	184	29	the	the	DT
cord-305263-fgwf6wy3	184	30	IFN	IFN	NNP
cord-305263-fgwf6wy3	184	31	-	-	HYPH
cord-305263-fgwf6wy3	184	32	inducible	inducible	JJ
cord-305263-fgwf6wy3	184	33	JAK	JAK	NNP
cord-305263-fgwf6wy3	184	34	-	-	HYPH
cord-305263-fgwf6wy3	184	35	STAT	STAT	NNP
cord-305263-fgwf6wy3	184	36	signaling	signal	VBG
cord-305263-fgwf6wy3	184	37	pathway	pathway	NN
cord-305263-fgwf6wy3	184	38	by	by	IN
cord-305263-fgwf6wy3	184	39	inhibiting	inhibit	VBG
cord-305263-fgwf6wy3	184	40	IFN	IFN	NNP
cord-305263-fgwf6wy3	184	41	-	-	HYPH
cord-305263-fgwf6wy3	184	42	inducible	inducible	JJ
cord-305263-fgwf6wy3	184	43	STAT1	stat1	NN
cord-305263-fgwf6wy3	184	44	phosphorylation	phosphorylation	NN
cord-305263-fgwf6wy3	184	45	and	and	CC
cord-305263-fgwf6wy3	184	46	nuclear	nuclear	JJ
cord-305263-fgwf6wy3	184	47	translocation	translocation	NN
cord-305263-fgwf6wy3	184	48	[	[	-LRB-
cord-305263-fgwf6wy3	184	49	21	21	CD
cord-305263-fgwf6wy3	184	50	]	]	-RRB-
cord-305263-fgwf6wy3	184	51	.	.	.
cord-305263-fgwf6wy3	185	1	Furthermore	furthermore	RB
cord-305263-fgwf6wy3	185	2	,	,	,
cord-305263-fgwf6wy3	185	3	HSV	HSV	NNP
cord-305263-fgwf6wy3	185	4	structural	structural	JJ
cord-305263-fgwf6wy3	185	5	protein	protein	NN
cord-305263-fgwf6wy3	185	6	US11	US11	NNP
cord-305263-fgwf6wy3	185	7	,	,	,
cord-305263-fgwf6wy3	185	8	which	which	WDT
cord-305263-fgwf6wy3	185	9	has	have	VBZ
cord-305263-fgwf6wy3	185	10	a	a	DT
cord-305263-fgwf6wy3	185	11	dsRNA	dsrna	RB
cord-305263-fgwf6wy3	185	12	-	-	HYPH
cord-305263-fgwf6wy3	185	13	binding	bind	VBG
cord-305263-fgwf6wy3	185	14	domain	domain	NN
cord-305263-fgwf6wy3	185	15	,	,	,
cord-305263-fgwf6wy3	185	16	disrupts	disrupt	VBZ
cord-305263-fgwf6wy3	185	17	the	the	DT
cord-305263-fgwf6wy3	185	18	activation	activation	NN
cord-305263-fgwf6wy3	185	19	of	of	IN
cord-305263-fgwf6wy3	185	20	the	the	DT
cord-305263-fgwf6wy3	185	21	IFNinducible	ifninducible	JJ
cord-305263-fgwf6wy3	185	22	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	185	23	proteins	protein	NNS
cord-305263-fgwf6wy3	185	24	2	2	CD
cord-305263-fgwf6wy3	185	25	0	0	CD
cord-305263-fgwf6wy3	185	26	,	,	,
cord-305263-fgwf6wy3	185	27	5	5	CD
cord-305263-fgwf6wy3	185	28	0	0	CD
cord-305263-fgwf6wy3	185	29	-OAS	-OAS	-RRB-
cord-305263-fgwf6wy3	185	30	and	and	CC
cord-305263-fgwf6wy3	185	31	PKR	PKR	NNP
cord-305263-fgwf6wy3	185	32	[	[	-LRB-
cord-305263-fgwf6wy3	185	33	64	64	CD
cord-305263-fgwf6wy3	185	34	]	]	-RRB-
cord-305263-fgwf6wy3	185	35	.	.	.
cord-305263-fgwf6wy3	186	1	For	for	IN
cord-305263-fgwf6wy3	186	2	immunocompromised	immunocompromised	JJ
cord-305263-fgwf6wy3	186	3	individuals	individual	NNS
cord-305263-fgwf6wy3	186	4	infected	infect	VBN
cord-305263-fgwf6wy3	186	5	with	with	IN
cord-305263-fgwf6wy3	186	6	HSV-1	hsv-1	NN
cord-305263-fgwf6wy3	186	7	,	,	,
cord-305263-fgwf6wy3	186	8	viral	viral	JJ
cord-305263-fgwf6wy3	186	9	pathogenesis	pathogenesis	NN
cord-305263-fgwf6wy3	186	10	can	can	MD
cord-305263-fgwf6wy3	186	11	lead	lead	VB
cord-305263-fgwf6wy3	186	12	to	to	IN
cord-305263-fgwf6wy3	186	13	serious	serious	JJ
cord-305263-fgwf6wy3	186	14	life	life	NN
cord-305263-fgwf6wy3	186	15	-	-	HYPH
cord-305263-fgwf6wy3	186	16	threatening	threaten	VBG
cord-305263-fgwf6wy3	186	17	disease	disease	NN
cord-305263-fgwf6wy3	186	18	;	;	:
cord-305263-fgwf6wy3	186	19	more	more	RBR
cord-305263-fgwf6wy3	186	20	so	so	RB
cord-305263-fgwf6wy3	186	21	in	in	IN
cord-305263-fgwf6wy3	186	22	the	the	DT
cord-305263-fgwf6wy3	186	23	context	context	NN
cord-305263-fgwf6wy3	186	24	of	of	IN
cord-305263-fgwf6wy3	186	25	emergent	emergent	JJ
cord-305263-fgwf6wy3	186	26	drug	drug	NN
cord-305263-fgwf6wy3	186	27	-	-	HYPH
cord-305263-fgwf6wy3	186	28	resistant	resistant	JJ
cord-305263-fgwf6wy3	186	29	HSV-1	hsv-1	NN
cord-305263-fgwf6wy3	186	30	strains	strain	NNS
cord-305263-fgwf6wy3	186	31	[	[	-LRB-
cord-305263-fgwf6wy3	186	32	65	65	CD
cord-305263-fgwf6wy3	186	33	]	]	-RRB-
cord-305263-fgwf6wy3	187	1	[	[	-LRB-
cord-305263-fgwf6wy3	187	2	66	66	CD
cord-305263-fgwf6wy3	187	3	]	]	-RRB-
cord-305263-fgwf6wy3	187	4	[	[	-LRB-
cord-305263-fgwf6wy3	187	5	67	67	CD
cord-305263-fgwf6wy3	187	6	]	]	-RRB-
cord-305263-fgwf6wy3	187	7	.	.	.
cord-305263-fgwf6wy3	188	1	Different	different	JJ
cord-305263-fgwf6wy3	188	2	DAAs	daa	NNS
cord-305263-fgwf6wy3	188	3	have	have	VBP
cord-305263-fgwf6wy3	188	4	been	be	VBN
cord-305263-fgwf6wy3	188	5	used	use	VBN
cord-305263-fgwf6wy3	188	6	to	to	TO
cord-305263-fgwf6wy3	188	7	control	control	VB
cord-305263-fgwf6wy3	188	8	HSV-1	hsv-1	NN
cord-305263-fgwf6wy3	188	9	infection	infection	NN
cord-305263-fgwf6wy3	188	10	,	,	,
cord-305263-fgwf6wy3	188	11	including	include	VBG
cord-305263-fgwf6wy3	188	12	acyclovir	acyclovir	NNP
cord-305263-fgwf6wy3	188	13	,	,	,
cord-305263-fgwf6wy3	188	14	penciclovir	penciclovir	NNPS
cord-305263-fgwf6wy3	188	15	and	and	CC
cord-305263-fgwf6wy3	188	16	foscarnet	foscarnet	NNP
cord-305263-fgwf6wy3	188	17	,	,	,
cord-305263-fgwf6wy3	188	18	resulting	result	VBG
cord-305263-fgwf6wy3	188	19	in	in	IN
cord-305263-fgwf6wy3	188	20	the	the	DT
cord-305263-fgwf6wy3	188	21	emergence	emergence	NN
cord-305263-fgwf6wy3	188	22	of	of	IN
cord-305263-fgwf6wy3	188	23	DAA	daa	NN
cord-305263-fgwf6wy3	188	24	-	-	HYPH
cord-305263-fgwf6wy3	188	25	resistant	resistant	JJ
cord-305263-fgwf6wy3	188	26	HSV-1	hsv-1	NN
cord-305263-fgwf6wy3	188	27	strains	strain	NNS
cord-305263-fgwf6wy3	188	28	[	[	-LRB-
cord-305263-fgwf6wy3	188	29	65	65	CD
cord-305263-fgwf6wy3	188	30	]	]	-RRB-
cord-305263-fgwf6wy3	189	1	[	[	-LRB-
cord-305263-fgwf6wy3	189	2	66	66	CD
cord-305263-fgwf6wy3	189	3	]	]	-RRB-
cord-305263-fgwf6wy3	189	4	[	[	-LRB-
cord-305263-fgwf6wy3	189	5	67	67	CD
cord-305263-fgwf6wy3	189	6	]	]	-RRB-
cord-305263-fgwf6wy3	189	7	.	.	.
cord-305263-fgwf6wy3	190	1	IFN	IFN	NNP
cord-305263-fgwf6wy3	190	2	-	-	HYPH
cord-305263-fgwf6wy3	190	3	g	g	NNP
cord-305263-fgwf6wy3	190	4	is	be	VBZ
cord-305263-fgwf6wy3	190	5	able	able	JJ
cord-305263-fgwf6wy3	190	6	to	to	TO
cord-305263-fgwf6wy3	190	7	exert	exert	VB
cord-305263-fgwf6wy3	190	8	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	190	9	activity	activity	NN
cord-305263-fgwf6wy3	190	10	by	by	IN
cord-305263-fgwf6wy3	190	11	stimulating	stimulate	VBG
cord-305263-fgwf6wy3	190	12	a	a	DT
cord-305263-fgwf6wy3	190	13	T	T	NNP
cord-305263-fgwf6wy3	190	14	cell	cell	NN
cord-305263-fgwf6wy3	190	15	response	response	NN
cord-305263-fgwf6wy3	190	16	.	.	.
cord-305263-fgwf6wy3	191	1	However	however	RB
cord-305263-fgwf6wy3	191	2	,	,	,
cord-305263-fgwf6wy3	191	3	IFN	IFN	NNP
cord-305263-fgwf6wy3	191	4	-	-	HYPH
cord-305263-fgwf6wy3	191	5	g	g	NNP
cord-305263-fgwf6wy3	191	6	alone	alone	RB
cord-305263-fgwf6wy3	191	7	may	may	MD
cord-305263-fgwf6wy3	191	8	have	have	VB
cord-305263-fgwf6wy3	191	9	limited	limited	JJ
cord-305263-fgwf6wy3	191	10	efficacy	efficacy	NN
cord-305263-fgwf6wy3	191	11	in	in	IN
cord-305263-fgwf6wy3	191	12	immunocompromised	immunocompromised	JJ
cord-305263-fgwf6wy3	191	13	HSV-1-infected	hsv-1-infecte	VBN
cord-305263-fgwf6wy3	191	14	individuals	individual	NNS
cord-305263-fgwf6wy3	191	15	lacking	lack	VBG
cord-305263-fgwf6wy3	191	16	a	a	DT
cord-305263-fgwf6wy3	191	17	robust	robust	JJ
cord-305263-fgwf6wy3	191	18	adaptive	adaptive	JJ
cord-305263-fgwf6wy3	191	19	immune	immune	JJ
cord-305263-fgwf6wy3	191	20	response	response	NN
cord-305263-fgwf6wy3	191	21	.	.	.
cord-305263-fgwf6wy3	192	1	Recent	recent	JJ
cord-305263-fgwf6wy3	192	2	studies	study	NNS
cord-305263-fgwf6wy3	192	3	have	have	VBP
cord-305263-fgwf6wy3	192	4	shown	show	VBN
cord-305263-fgwf6wy3	192	5	that	that	IN
cord-305263-fgwf6wy3	192	6	when	when	WRB
cord-305263-fgwf6wy3	192	7	immunocompromised	immunocompromised	JJ
cord-305263-fgwf6wy3	192	8	nude	nude	JJ
cord-305263-fgwf6wy3	192	9	mice	mouse	NNS
cord-305263-fgwf6wy3	192	10	are	be	VBP
cord-305263-fgwf6wy3	192	11	infected	infect	VBN
cord-305263-fgwf6wy3	192	12	with	with	IN
cord-305263-fgwf6wy3	192	13	a	a	DT
cord-305263-fgwf6wy3	192	14	DAA	DAA	NNP
cord-305263-fgwf6wy3	192	15	(	(	-LRB-
cord-305263-fgwf6wy3	192	16	acyclovir)-resistant	acyclovir)-resistant	NNP
cord-305263-fgwf6wy3	192	17	HSV-1	HSV-1	NNP
cord-305263-fgwf6wy3	192	18	variant	variant	NN
cord-305263-fgwf6wy3	192	19	and	and	CC
cord-305263-fgwf6wy3	192	20	treated	treat	VBN
cord-305263-fgwf6wy3	192	21	with	with	IN
cord-305263-fgwf6wy3	192	22	IFN	IFN	NNP
cord-305263-fgwf6wy3	192	23	-	-	HYPH
cord-305263-fgwf6wy3	192	24	b	b	NNP
cord-305263-fgwf6wy3	192	25	in	in	IN
cord-305263-fgwf6wy3	192	26	combination	combination	NN
cord-305263-fgwf6wy3	192	27	with	with	IN
cord-305263-fgwf6wy3	192	28	IFN	IFN	NNP
cord-305263-fgwf6wy3	192	29	-	-	HYPH
cord-305263-fgwf6wy3	192	30	g	g	NNP
cord-305263-fgwf6wy3	192	31	,	,	,
cord-305263-fgwf6wy3	192	32	viral	viral	JJ
cord-305263-fgwf6wy3	192	33	infection	infection	NN
cord-305263-fgwf6wy3	192	34	is	be	VBZ
cord-305263-fgwf6wy3	192	35	reduced	reduce	VBN
cord-305263-fgwf6wy3	192	36	[	[	-LRB-
cord-305263-fgwf6wy3	192	37	65	65	CD
cord-305263-fgwf6wy3	192	38	]	]	-RRB-
cord-305263-fgwf6wy3	192	39	.	.	.
cord-305263-fgwf6wy3	193	1	These	these	DT
cord-305263-fgwf6wy3	193	2	preliminary	preliminary	JJ
cord-305263-fgwf6wy3	193	3	data	datum	NNS
cord-305263-fgwf6wy3	193	4	are	be	VBP
cord-305263-fgwf6wy3	193	5	in	in	IN
cord-305263-fgwf6wy3	193	6	further	further	JJ
cord-305263-fgwf6wy3	193	7	support	support	NN
cord-305263-fgwf6wy3	193	8	of	of	IN
cord-305263-fgwf6wy3	193	9	the	the	DT
cord-305263-fgwf6wy3	193	10	broadspectrum	broadspectrum	NNP
cord-305263-fgwf6wy3	193	11	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	193	12	activities	activity	NNS
cord-305263-fgwf6wy3	193	13	of	of	IN
cord-305263-fgwf6wy3	193	14	IFNs	ifns	NN
cord-305263-fgwf6wy3	193	15	-	-	:
cord-305263-fgwf6wy3	193	16	a	a	NN
cord-305263-fgwf6wy3	193	17	/	/	SYM
cord-305263-fgwf6wy3	193	18	b	b	NN
cord-305263-fgwf6wy3	193	19	.	.	.
cord-305263-fgwf6wy3	194	1	Shifting	shift	VBG
cord-305263-fgwf6wy3	194	2	the	the	DT
cord-305263-fgwf6wy3	194	3	balance	balance	NN
cord-305263-fgwf6wy3	194	4	to	to	TO
cord-305263-fgwf6wy3	194	5	favor	favor	VB
cord-305263-fgwf6wy3	194	6	the	the	DT
cord-305263-fgwf6wy3	194	7	host	host	NN
cord-305263-fgwf6wy3	194	8	innate	innate	JJ
cord-305263-fgwf6wy3	194	9	immune	immune	JJ
cord-305263-fgwf6wy3	194	10	response	response	NN
cord-305263-fgwf6wy3	194	11	:	:	:
cord-305263-fgwf6wy3	194	12	the	the	DT
cord-305263-fgwf6wy3	194	13	future	future	NN
cord-305263-fgwf6wy3	194	14	of	of	IN
cord-305263-fgwf6wy3	194	15	IFN	IFN	NNP
cord-305263-fgwf6wy3	194	16	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	194	17	therapy	therapy	NN
cord-305263-fgwf6wy3	194	18	Mechanisms	mechanism	NNS
cord-305263-fgwf6wy3	194	19	for	for	IN
cord-305263-fgwf6wy3	194	20	viral	viral	JJ
cord-305263-fgwf6wy3	194	21	evasion	evasion	NN
cord-305263-fgwf6wy3	194	22	of	of	IN
cord-305263-fgwf6wy3	194	23	the	the	DT
cord-305263-fgwf6wy3	194	24	host	host	NN
cord-305263-fgwf6wy3	194	25	immune	immune	JJ
cord-305263-fgwf6wy3	194	26	response	response	NN
cord-305263-fgwf6wy3	194	27	include	include	VBP
cord-305263-fgwf6wy3	194	28	both	both	CC
cord-305263-fgwf6wy3	194	29	the	the	DT
cord-305263-fgwf6wy3	194	30	expression	expression	NN
cord-305263-fgwf6wy3	194	31	of	of	IN
cord-305263-fgwf6wy3	194	32	many	many	JJ
cord-305263-fgwf6wy3	194	33	virulence	virulence	NN
cord-305263-fgwf6wy3	194	34	factors	factor	NNS
cord-305263-fgwf6wy3	194	35	by	by	IN
cord-305263-fgwf6wy3	194	36	a	a	DT
cord-305263-fgwf6wy3	194	37	Review	Review	NNP
cord-305263-fgwf6wy3	194	38	Trends	Trends	NNPS
cord-305263-fgwf6wy3	194	39	in	in	IN
cord-305263-fgwf6wy3	194	40	Immunology	Immunology	NNP
cord-305263-fgwf6wy3	194	41	April	April	NNP
cord-305263-fgwf6wy3	194	42	2012	2012	CD
cord-305263-fgwf6wy3	194	43	,	,	,
cord-305263-fgwf6wy3	194	44	Vol	Vol	NNP
cord-305263-fgwf6wy3	194	45	.	.	.
cord-305263-fgwf6wy3	195	1	33	33	CD
cord-305263-fgwf6wy3	195	2	,	,	,
cord-305263-fgwf6wy3	195	3	No	no	NN
cord-305263-fgwf6wy3	195	4	.	.	NN
cord-305263-fgwf6wy3	195	5	4	4	CD
cord-305263-fgwf6wy3	195	6	single	single	JJ
cord-305263-fgwf6wy3	195	7	virus	virus	NN
cord-305263-fgwf6wy3	195	8	to	to	TO
cord-305263-fgwf6wy3	195	9	target	target	VB
cord-305263-fgwf6wy3	195	10	different	different	JJ
cord-305263-fgwf6wy3	195	11	stages	stage	NNS
cord-305263-fgwf6wy3	195	12	of	of	IN
cord-305263-fgwf6wy3	195	13	the	the	DT
cord-305263-fgwf6wy3	195	14	IFN	IFN	NNP
cord-305263-fgwf6wy3	195	15	response	response	NN
cord-305263-fgwf6wy3	195	16	,	,	,
cord-305263-fgwf6wy3	195	17	or	or	CC
cord-305263-fgwf6wy3	195	18	the	the	DT
cord-305263-fgwf6wy3	195	19	expression	expression	NN
cord-305263-fgwf6wy3	195	20	of	of	IN
cord-305263-fgwf6wy3	195	21	a	a	DT
cord-305263-fgwf6wy3	195	22	single	single	JJ
cord-305263-fgwf6wy3	195	23	,	,	,
cord-305263-fgwf6wy3	195	24	highly	highly	RB
cord-305263-fgwf6wy3	195	25	specialized	specialized	JJ
cord-305263-fgwf6wy3	195	26	molecule	molecule	NN
cord-305263-fgwf6wy3	195	27	that	that	WDT
cord-305263-fgwf6wy3	195	28	alone	alone	RB
cord-305263-fgwf6wy3	195	29	targets	target	VBZ
cord-305263-fgwf6wy3	195	30	multiple	multiple	JJ
cord-305263-fgwf6wy3	195	31	facets	facet	NNS
cord-305263-fgwf6wy3	195	32	of	of	IN
cord-305263-fgwf6wy3	195	33	an	an	DT
cord-305263-fgwf6wy3	195	34	IFN	IFN	NNP
cord-305263-fgwf6wy3	195	35	response	response	NN
cord-305263-fgwf6wy3	195	36	.	.	.
cord-305263-fgwf6wy3	196	1	A	a	DT
cord-305263-fgwf6wy3	196	2	priori	priori	FW
cord-305263-fgwf6wy3	196	3	,	,	,
cord-305263-fgwf6wy3	196	4	the	the	DT
cord-305263-fgwf6wy3	196	5	widespread	widespread	JJ
cord-305263-fgwf6wy3	196	6	existence	existence	NN
cord-305263-fgwf6wy3	196	7	of	of	IN
cord-305263-fgwf6wy3	196	8	these	these	DT
cord-305263-fgwf6wy3	196	9	virally	virally	RB
cord-305263-fgwf6wy3	196	10	encoded	encode	VBN
cord-305263-fgwf6wy3	196	11	virulence	virulence	NN
cord-305263-fgwf6wy3	196	12	factors	factor	NNS
cord-305263-fgwf6wy3	196	13	that	that	WDT
cord-305263-fgwf6wy3	196	14	target	target	VBP
cord-305263-fgwf6wy3	196	15	an	an	DT
cord-305263-fgwf6wy3	196	16	IFN	IFN	NNP
cord-305263-fgwf6wy3	196	17	response	response	NN
cord-305263-fgwf6wy3	196	18	highlights	highlight	VBZ
cord-305263-fgwf6wy3	196	19	the	the	DT
cord-305263-fgwf6wy3	196	20	critical	critical	JJ
cord-305263-fgwf6wy3	196	21	role	role	NN
cord-305263-fgwf6wy3	196	22	of	of	IN
cord-305263-fgwf6wy3	196	23	a	a	DT
cord-305263-fgwf6wy3	196	24	robust	robust	JJ
cord-305263-fgwf6wy3	196	25	IFN	IFN	NNP
cord-305263-fgwf6wy3	196	26	response	response	NN
cord-305263-fgwf6wy3	196	27	to	to	IN
cord-305263-fgwf6wy3	196	28	limiting	limit	VBG
cord-305263-fgwf6wy3	196	29	virus	virus	NN
cord-305263-fgwf6wy3	196	30	infection	infection	NN
cord-305263-fgwf6wy3	196	31	.	.	.
cord-305263-fgwf6wy3	197	1	The	the	DT
cord-305263-fgwf6wy3	197	2	ability	ability	NN
cord-305263-fgwf6wy3	197	3	of	of	IN
cord-305263-fgwf6wy3	197	4	IFNs	ifns	NN
cord-305263-fgwf6wy3	197	5	-	-	:
cord-305263-fgwf6wy3	197	6	a	a	NN
cord-305263-fgwf6wy3	197	7	/	/	SYM
cord-305263-fgwf6wy3	197	8	b	b	NN
cord-305263-fgwf6wy3	197	9	to	to	TO
cord-305263-fgwf6wy3	197	10	target	target	VB
cord-305263-fgwf6wy3	197	11	multiple	multiple	JJ
cord-305263-fgwf6wy3	197	12	types	type	NNS
cord-305263-fgwf6wy3	197	13	of	of	IN
cord-305263-fgwf6wy3	197	14	viruses	virus	NNS
cord-305263-fgwf6wy3	197	15	at	at	IN
cord-305263-fgwf6wy3	197	16	different	different	JJ
cord-305263-fgwf6wy3	197	17	stages	stage	NNS
cord-305263-fgwf6wy3	197	18	of	of	IN
cord-305263-fgwf6wy3	197	19	viral	viral	JJ
cord-305263-fgwf6wy3	197	20	replication	replication	NN
cord-305263-fgwf6wy3	197	21	,	,	,
cord-305263-fgwf6wy3	197	22	and	and	CC
cord-305263-fgwf6wy3	197	23	the	the	DT
cord-305263-fgwf6wy3	197	24	ubiquitous	ubiquitous	JJ
cord-305263-fgwf6wy3	197	25	expression	expression	NN
cord-305263-fgwf6wy3	197	26	of	of	IN
cord-305263-fgwf6wy3	197	27	IFN	IFN	NNP
cord-305263-fgwf6wy3	197	28	receptors	receptor	NNS
cord-305263-fgwf6wy3	197	29	on	on	IN
cord-305263-fgwf6wy3	197	30	cells	cell	NNS
cord-305263-fgwf6wy3	197	31	that	that	WDT
cord-305263-fgwf6wy3	197	32	are	be	VBP
cord-305263-fgwf6wy3	197	33	susceptible	susceptible	JJ
cord-305263-fgwf6wy3	197	34	to	to	IN
cord-305263-fgwf6wy3	197	35	different	different	JJ
cord-305263-fgwf6wy3	197	36	virus	virus	NN
cord-305263-fgwf6wy3	197	37	infections	infection	NNS
cord-305263-fgwf6wy3	197	38	with	with	IN
cord-305263-fgwf6wy3	197	39	different	different	JJ
cord-305263-fgwf6wy3	197	40	tissue	tissue	NN
cord-305263-fgwf6wy3	197	41	tropisms	tropism	NNS
cord-305263-fgwf6wy3	197	42	,	,	,
cord-305263-fgwf6wy3	197	43	as	as	RB
cord-305263-fgwf6wy3	197	44	well	well	RB
cord-305263-fgwf6wy3	197	45	as	as	IN
cord-305263-fgwf6wy3	197	46	the	the	DT
cord-305263-fgwf6wy3	197	47	ability	ability	NN
cord-305263-fgwf6wy3	197	48	of	of	IN
cord-305263-fgwf6wy3	197	49	IFNs	ifn	NNS
cord-305263-fgwf6wy3	197	50	to	to	TO
cord-305263-fgwf6wy3	197	51	activate	activate	VB
cord-305263-fgwf6wy3	197	52	innate	innate	JJ
cord-305263-fgwf6wy3	197	53	immune	immune	JJ
cord-305263-fgwf6wy3	197	54	cells	cell	NNS
cord-305263-fgwf6wy3	197	55	and	and	CC
cord-305263-fgwf6wy3	197	56	influence	influence	VB
cord-305263-fgwf6wy3	197	57	the	the	DT
cord-305263-fgwf6wy3	197	58	adaptive	adaptive	JJ
cord-305263-fgwf6wy3	197	59	immune	immune	JJ
cord-305263-fgwf6wy3	197	60	response	response	NN
cord-305263-fgwf6wy3	197	61	,	,	,
cord-305263-fgwf6wy3	197	62	emphasizes	emphasize	VBZ
cord-305263-fgwf6wy3	197	63	the	the	DT
cord-305263-fgwf6wy3	197	64	relevance	relevance	NN
cord-305263-fgwf6wy3	197	65	of	of	IN
cord-305263-fgwf6wy3	197	66	IFNs	ifns	NN
cord-305263-fgwf6wy3	197	67	-	-	:
cord-305263-fgwf6wy3	197	68	a	a	NN
cord-305263-fgwf6wy3	197	69	/	/	SYM
cord-305263-fgwf6wy3	197	70	b	b	NN
cord-305263-fgwf6wy3	197	71	as	as	IN
cord-305263-fgwf6wy3	197	72	broadspectrum	broadspectrum	NNP
cord-305263-fgwf6wy3	197	73	antivirals	antiviral	NNS
cord-305263-fgwf6wy3	197	74	.	.	.
cord-305263-fgwf6wy3	198	1	Understanding	understand	VBG
cord-305263-fgwf6wy3	198	2	the	the	DT
cord-305263-fgwf6wy3	198	3	viral	viral	JJ
cord-305263-fgwf6wy3	198	4	strategies	strategy	NNS
cord-305263-fgwf6wy3	198	5	for	for	IN
cord-305263-fgwf6wy3	198	6	evasion	evasion	NN
cord-305263-fgwf6wy3	198	7	of	of	IN
cord-305263-fgwf6wy3	198	8	an	an	DT
cord-305263-fgwf6wy3	198	9	IFN	IFN	NNP
cord-305263-fgwf6wy3	198	10	will	will	MD
cord-305263-fgwf6wy3	198	11	permit	permit	VB
cord-305263-fgwf6wy3	198	12	the	the	DT
cord-305263-fgwf6wy3	198	13	design	design	NN
cord-305263-fgwf6wy3	198	14	of	of	IN
cord-305263-fgwf6wy3	198	15	strategic	strategic	JJ
cord-305263-fgwf6wy3	198	16	IFN	IFN	NNP
cord-305263-fgwf6wy3	198	17	treatment	treatment	NN
cord-305263-fgwf6wy3	198	18	regimens	regimen	NNS
cord-305263-fgwf6wy3	198	19	to	to	IN
cord-305263-fgwf6wy3	198	20	both	both	DT
cord-305263-fgwf6wy3	198	21	protect	protect	VB
cord-305263-fgwf6wy3	198	22	from	from	IN
cord-305263-fgwf6wy3	198	23	and	and	CC
cord-305263-fgwf6wy3	198	24	clear	clear	JJ
cord-305263-fgwf6wy3	198	25	virus	virus	NN
cord-305263-fgwf6wy3	198	26	infections	infection	NNS
cord-305263-fgwf6wy3	198	27	.	.	.
cord-305263-fgwf6wy3	199	1	The	the	DT
cord-305263-fgwf6wy3	199	2	opportunity	opportunity	NN
cord-305263-fgwf6wy3	199	3	to	to	TO
cord-305263-fgwf6wy3	199	4	limit	limit	VB
cord-305263-fgwf6wy3	199	5	virus	virus	NN
cord-305263-fgwf6wy3	199	6	infections	infection	NNS
cord-305263-fgwf6wy3	199	7	even	even	RB
cord-305263-fgwf6wy3	199	8	in	in	IN
cord-305263-fgwf6wy3	199	9	the	the	DT
cord-305263-fgwf6wy3	199	10	absence	absence	NN
cord-305263-fgwf6wy3	199	11	of	of	IN
cord-305263-fgwf6wy3	199	12	characterizing	characterize	VBG
cord-305263-fgwf6wy3	199	13	the	the	DT
cord-305263-fgwf6wy3	199	14	specific	specific	JJ
cord-305263-fgwf6wy3	199	15	infecting	infect	VBG
cord-305263-fgwf6wy3	199	16	virus	virus	NN
cord-305263-fgwf6wy3	199	17	,	,	,
cord-305263-fgwf6wy3	199	18	a	a	DT
cord-305263-fgwf6wy3	199	19	reality	reality	NN
cord-305263-fgwf6wy3	199	20	during	during	IN
cord-305263-fgwf6wy3	199	21	an	an	DT
cord-305263-fgwf6wy3	199	22	outbreak	outbreak	NN
cord-305263-fgwf6wy3	199	23	of	of	IN
cord-305263-fgwf6wy3	199	24	unknown	unknown	JJ
cord-305263-fgwf6wy3	199	25	etiology	etiology	NN
cord-305263-fgwf6wy3	199	26	,	,	,
cord-305263-fgwf6wy3	199	27	or	or	CC
cord-305263-fgwf6wy3	199	28	during	during	IN
cord-305263-fgwf6wy3	199	29	a	a	DT
cord-305263-fgwf6wy3	199	30	pandemic	pandemic	NN
cord-305263-fgwf6wy3	199	31	of	of	IN
cord-305263-fgwf6wy3	199	32	a	a	DT
cord-305263-fgwf6wy3	199	33	newly	newly	RB
cord-305263-fgwf6wy3	199	34	emerging	emerge	VBG
cord-305263-fgwf6wy3	199	35	or	or	CC
cord-305263-fgwf6wy3	199	36	re	re	VB
cord-305263-fgwf6wy3	199	37	-	-	JJ
cord-305263-fgwf6wy3	199	38	emerging	emerge	VBG
cord-305263-fgwf6wy3	199	39	virus	virus	NN
cord-305263-fgwf6wy3	199	40	strain	strain	NN
cord-305263-fgwf6wy3	199	41	,	,	,
cord-305263-fgwf6wy3	199	42	has	have	VBZ
cord-305263-fgwf6wy3	199	43	profound	profound	JJ
cord-305263-fgwf6wy3	199	44	implications	implication	NNS
cord-305263-fgwf6wy3	199	45	for	for	IN
cord-305263-fgwf6wy3	199	46	global	global	JJ
cord-305263-fgwf6wy3	199	47	health	health	NN
cord-305263-fgwf6wy3	199	48	.	.	.
cord-305263-fgwf6wy3	200	1	Indeed	indeed	RB
cord-305263-fgwf6wy3	200	2	,	,	,
cord-305263-fgwf6wy3	200	3	early	early	JJ
cord-305263-fgwf6wy3	200	4	data	datum	NNS
cord-305263-fgwf6wy3	200	5	indicate	indicate	VBP
cord-305263-fgwf6wy3	200	6	that	that	IN
cord-305263-fgwf6wy3	200	7	IFN	IFN	NNP
cord-305263-fgwf6wy3	200	8	therapy	therapy	NN
cord-305263-fgwf6wy3	200	9	may	may	MD
cord-305263-fgwf6wy3	200	10	be	be	VB
cord-305263-fgwf6wy3	200	11	effective	effective	JJ
cord-305263-fgwf6wy3	200	12	in	in	IN
cord-305263-fgwf6wy3	200	13	treating	treat	VBG
cord-305263-fgwf6wy3	200	14	West	West	NNP
cord-305263-fgwf6wy3	200	15	Nile	Nile	NNP
cord-305263-fgwf6wy3	200	16	virus	virus	NN
cord-305263-fgwf6wy3	200	17	[	[	-LRB-
cord-305263-fgwf6wy3	200	18	68	68	CD
cord-305263-fgwf6wy3	200	19	]	]	-RRB-
cord-305263-fgwf6wy3	200	20	,	,	,
cord-305263-fgwf6wy3	200	21	hemorrhagic	hemorrhagic	JJ
cord-305263-fgwf6wy3	200	22	yellow	yellow	JJ
cord-305263-fgwf6wy3	200	23	fever	fever	NN
cord-305263-fgwf6wy3	200	24	virus	virus	NN
cord-305263-fgwf6wy3	200	25	[	[	-LRB-
cord-305263-fgwf6wy3	200	26	69	69	CD
cord-305263-fgwf6wy3	200	27	]	]	-RRB-
cord-305263-fgwf6wy3	200	28	and	and	CC
cord-305263-fgwf6wy3	200	29	Ebola	Ebola	NNP
cord-305263-fgwf6wy3	200	30	virus	virus	NN
cord-305263-fgwf6wy3	200	31	infections	infection	NNS
cord-305263-fgwf6wy3	200	32	[	[	-LRB-
cord-305263-fgwf6wy3	200	33	70	70	CD
cord-305263-fgwf6wy3	200	34	]	]	-RRB-
cord-305263-fgwf6wy3	200	35	.	.	.
cord-305263-fgwf6wy3	201	1	Moreover	moreover	RB
cord-305263-fgwf6wy3	201	2	,	,	,
cord-305263-fgwf6wy3	201	3	short	short	JJ
cord-305263-fgwf6wy3	201	4	-	-	HYPH
cord-305263-fgwf6wy3	201	5	term	term	NN
cord-305263-fgwf6wy3	201	6	IFN	IFN	NNP
cord-305263-fgwf6wy3	201	7	therapy	therapy	NN
cord-305263-fgwf6wy3	201	8	for	for	IN
cord-305263-fgwf6wy3	201	9	an	an	DT
cord-305263-fgwf6wy3	201	10	acute	acute	JJ
cord-305263-fgwf6wy3	201	11	virus	virus	NN
cord-305263-fgwf6wy3	201	12	infection	infection	NN
cord-305263-fgwf6wy3	201	13	may	may	MD
cord-305263-fgwf6wy3	201	14	not	not	RB
cord-305263-fgwf6wy3	201	15	invoke	invoke	VB
cord-305263-fgwf6wy3	201	16	the	the	DT
cord-305263-fgwf6wy3	201	17	debilitating	debilitating	JJ
cord-305263-fgwf6wy3	201	18	side	side	NN
cord-305263-fgwf6wy3	201	19	effects	effect	NNS
cord-305263-fgwf6wy3	201	20	associated	associate	VBN
cord-305263-fgwf6wy3	201	21	with	with	IN
cord-305263-fgwf6wy3	201	22	long	long	JJ
cord-305263-fgwf6wy3	201	23	-	-	HYPH
cord-305263-fgwf6wy3	201	24	term	term	NN
cord-305263-fgwf6wy3	201	25	IFN	IFN	NNP
cord-305263-fgwf6wy3	201	26	therapy	therapy	NN
cord-305263-fgwf6wy3	201	27	for	for	IN
cord-305263-fgwf6wy3	201	28	chronic	chronic	JJ
cord-305263-fgwf6wy3	201	29	infections	infection	NNS
cord-305263-fgwf6wy3	201	30	such	such	JJ
cord-305263-fgwf6wy3	201	31	as	as	IN
cord-305263-fgwf6wy3	201	32	HBV	HBV	NNP
cord-305263-fgwf6wy3	201	33	and	and	CC
cord-305263-fgwf6wy3	201	34	HCV	HCV	NNP
cord-305263-fgwf6wy3	201	35	.	.	.
cord-305263-fgwf6wy3	202	1	Preliminary	preliminary	JJ
cord-305263-fgwf6wy3	202	2	data	datum	NNS
cord-305263-fgwf6wy3	202	3	from	from	IN
cord-305263-fgwf6wy3	202	4	pilot	pilot	JJ
cord-305263-fgwf6wy3	202	5	clinical	clinical	JJ
cord-305263-fgwf6wy3	202	6	trials	trial	NNS
cord-305263-fgwf6wy3	202	7	of	of	IN
cord-305263-fgwf6wy3	202	8	IFN	IFN	NNP
cord-305263-fgwf6wy3	202	9	treatment	treatment	NN
cord-305263-fgwf6wy3	202	10	for	for	IN
cord-305263-fgwf6wy3	202	11	SARS	SARS	NNP
cord-305263-fgwf6wy3	202	12	-	-	HYPH
cord-305263-fgwf6wy3	202	13	CoV	CoV	NNP
cord-305263-fgwf6wy3	202	14	and	and	CC
cord-305263-fgwf6wy3	202	15	for	for	IN
cord-305263-fgwf6wy3	202	16	influenza	influenza	NN
cord-305263-fgwf6wy3	202	17	A	a	DT
cord-305263-fgwf6wy3	202	18	viruses	virus	NNS
cord-305263-fgwf6wy3	202	19	showed	show	VBD
cord-305263-fgwf6wy3	202	20	this	this	DT
cord-305263-fgwf6wy3	202	21	to	to	TO
cord-305263-fgwf6wy3	202	22	be	be	VB
cord-305263-fgwf6wy3	202	23	the	the	DT
cord-305263-fgwf6wy3	202	24	case	case	NN
cord-305263-fgwf6wy3	202	25	[	[	-LRB-
cord-305263-fgwf6wy3	202	26	46	46	CD
cord-305263-fgwf6wy3	202	27	,	,	,
cord-305263-fgwf6wy3	202	28	52	52	CD
cord-305263-fgwf6wy3	202	29	]	]	-RRB-
cord-305263-fgwf6wy3	202	30	.	.	.
cord-305263-fgwf6wy3	203	1	Cognizance	cognizance	NN
cord-305263-fgwf6wy3	203	2	of	of	IN
cord-305263-fgwf6wy3	203	3	the	the	DT
cord-305263-fgwf6wy3	203	4	yin	yin	NNP
cord-305263-fgwf6wy3	203	5	and	and	CC
cord-305263-fgwf6wy3	203	6	yang	yang	NNP
cord-305263-fgwf6wy3	203	7	of	of	IN
cord-305263-fgwf6wy3	203	8	viruses	virus	NNS
cord-305263-fgwf6wy3	203	9	and	and	CC
cord-305263-fgwf6wy3	203	10	IFNs	IFNs	NNP
cord-305263-fgwf6wy3	203	11	opens	open	VBZ
cord-305263-fgwf6wy3	203	12	the	the	DT
cord-305263-fgwf6wy3	203	13	door	door	NN
cord-305263-fgwf6wy3	203	14	to	to	IN
cord-305263-fgwf6wy3	203	15	the	the	DT
cord-305263-fgwf6wy3	203	16	widespread	widespread	JJ
cord-305263-fgwf6wy3	203	17	clinical	clinical	JJ
cord-305263-fgwf6wy3	203	18	application	application	NN
cord-305263-fgwf6wy3	203	19	of	of	IN
cord-305263-fgwf6wy3	203	20	these	these	DT
cord-305263-fgwf6wy3	203	21	broad	broad	JJ
cord-305263-fgwf6wy3	203	22	-	-	HYPH
cord-305263-fgwf6wy3	203	23	spectrum	spectrum	NN
cord-305263-fgwf6wy3	203	24	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	203	25	IFNs	ifn	NNS
cord-305263-fgwf6wy3	203	26	.	.	.
cord-305263-fgwf6wy3	204	1	Type	type	NN
cord-305263-fgwf6wy3	204	2	I	-PRON-	PRP
cord-305263-fgwf6wy3	204	3	interferons	interferon	NNS
cord-305263-fgwf6wy3	204	4	in	in	IN
cord-305263-fgwf6wy3	204	5	host	host	NN
cord-305263-fgwf6wy3	204	6	defense	defense	NN
cord-305263-fgwf6wy3	204	7	Pathogen	Pathogen	NNP
cord-305263-fgwf6wy3	204	8	recognition	recognition	NN
cord-305263-fgwf6wy3	204	9	by	by	IN
cord-305263-fgwf6wy3	204	10	the	the	DT
cord-305263-fgwf6wy3	204	11	innate	innate	JJ
cord-305263-fgwf6wy3	204	12	immune	immune	JJ
cord-305263-fgwf6wy3	204	13	system	system	NN
cord-305263-fgwf6wy3	204	14	Mechanisms	Mechanisms	NNPS
cord-305263-fgwf6wy3	204	15	of	of	IN
cord-305263-fgwf6wy3	204	16	type-	type-	NNP
cord-305263-fgwf6wy3	205	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	205	2	-	-	HYPH
cord-305263-fgwf6wy3	205	3	and	and	CC
cord-305263-fgwf6wy3	205	4	type	type	NN
cord-305263-fgwf6wy3	205	5	-	-	HYPH
cord-305263-fgwf6wy3	205	6	II	ii	NN
cord-305263-fgwf6wy3	205	7	-	-	HYPH
cord-305263-fgwf6wy3	205	8	interferonmediated	interferonmediate	VBN
cord-305263-fgwf6wy3	205	9	signaling	signal	VBG
cord-305263-fgwf6wy3	205	10	IFITM	IFITM	NNP
cord-305263-fgwf6wy3	205	11	proteins	protein	NNS
cord-305263-fgwf6wy3	205	12	mediate	mediate	VBP
cord-305263-fgwf6wy3	205	13	the	the	DT
cord-305263-fgwf6wy3	205	14	innate	innate	JJ
cord-305263-fgwf6wy3	205	15	immune	immune	JJ
cord-305263-fgwf6wy3	205	16	response	response	NN
cord-305263-fgwf6wy3	205	17	to	to	TO
cord-305263-fgwf6wy3	205	18	influenza	influenza	VB
cord-305263-fgwf6wy3	205	19	A	a	DT
cord-305263-fgwf6wy3	205	20	H1N1	H1N1	NNP
cord-305263-fgwf6wy3	205	21	virus	virus	NN
cord-305263-fgwf6wy3	205	22	,	,	,
cord-305263-fgwf6wy3	205	23	West	West	NNP
cord-305263-fgwf6wy3	205	24	Nile	Nile	NNP
cord-305263-fgwf6wy3	205	25	virus	virus	NN
cord-305263-fgwf6wy3	205	26	and	and	CC
cord-305263-fgwf6wy3	205	27	dengue	dengue	NN
cord-305263-fgwf6wy3	205	28	virus	virus	NN
cord-305263-fgwf6wy3	205	29	)	)	-RRB-
cord-305263-fgwf6wy3	205	30	Type	type	NN
cord-305263-fgwf6wy3	205	31	I	i	NN
cord-305263-fgwf6wy3	205	32	and	and	CC
cord-305263-fgwf6wy3	205	33	type	type	NN
cord-305263-fgwf6wy3	205	34	II	II	NNP
cord-305263-fgwf6wy3	205	35	interferons	interferon	NNS
cord-305263-fgwf6wy3	205	36	delay	delay	VBP
cord-305263-fgwf6wy3	206	1	human	human	JJ
cord-305263-fgwf6wy3	206	2	neutrophil	neutrophil	NN
cord-305263-fgwf6wy3	206	3	apoptosis	apoptosis	NN
cord-305263-fgwf6wy3	206	4	via	via	IN
cord-305263-fgwf6wy3	206	5	activation	activation	NN
cord-305263-fgwf6wy3	206	6	of	of	IN
cord-305263-fgwf6wy3	206	7	STAT3	STAT3	NNP
cord-305263-fgwf6wy3	206	8	and	and	CC
cord-305263-fgwf6wy3	206	9	up	up	IN
cord-305263-fgwf6wy3	206	10	-	-	HYPH
cord-305263-fgwf6wy3	206	11	regulation	regulation	NN
cord-305263-fgwf6wy3	206	12	of	of	IN
cord-305263-fgwf6wy3	206	13	cellular	cellular	JJ
cord-305263-fgwf6wy3	206	14	inhibitor	inhibitor	NN
cord-305263-fgwf6wy3	206	15	of	of	IN
cord-305263-fgwf6wy3	206	16	apoptosis	apoptosis	NN
cord-305263-fgwf6wy3	206	17	2	2	CD
cord-305263-fgwf6wy3	206	18	Reversible	reversible	JJ
cord-305263-fgwf6wy3	206	19	inhibition	inhibition	NN
cord-305263-fgwf6wy3	206	20	of	of	IN
cord-305263-fgwf6wy3	206	21	murine	murine	JJ
cord-305263-fgwf6wy3	206	22	cytomegalovirus	cytomegalovirus	NN
cord-305263-fgwf6wy3	206	23	replication	replication	NN
cord-305263-fgwf6wy3	206	24	by	by	IN
cord-305263-fgwf6wy3	206	25	gamma	gamma	NN
cord-305263-fgwf6wy3	206	26	interferon	interferon	NN
cord-305263-fgwf6wy3	207	1	(	(	-LRB-
cord-305263-fgwf6wy3	207	2	IFN	IFN	NNP
cord-305263-fgwf6wy3	207	3	-	-	HYPH
cord-305263-fgwf6wy3	207	4	g	g	NNP
cord-305263-fgwf6wy3	207	5	)	)	-RRB-
cord-305263-fgwf6wy3	207	6	in	in	IN
cord-305263-fgwf6wy3	207	7	primary	primary	JJ
cord-305263-fgwf6wy3	207	8	macrophages	macrophage	NNS
cord-305263-fgwf6wy3	207	9	involves	involve	VBZ
cord-305263-fgwf6wy3	207	10	a	a	DT
cord-305263-fgwf6wy3	207	11	primed	primed	JJ
cord-305263-fgwf6wy3	207	12	type	type	NN
cord-305263-fgwf6wy3	207	13	I	-PRON-	PRP
cord-305263-fgwf6wy3	207	14	IFN	IFN	NNP
cord-305263-fgwf6wy3	207	15	-	-	HYPH
cord-305263-fgwf6wy3	207	16	signaling	signal	VBG
cord-305263-fgwf6wy3	207	17	subnetwork	subnetwork	NN
cord-305263-fgwf6wy3	207	18	for	for	IN
cord-305263-fgwf6wy3	207	19	full	full	JJ
cord-305263-fgwf6wy3	207	20	establishment	establishment	NN
cord-305263-fgwf6wy3	207	21	of	of	IN
cord-305263-fgwf6wy3	207	22	an	an	DT
cord-305263-fgwf6wy3	207	23	immediate	immediate	JJ
cord-305263-fgwf6wy3	207	24	-	-	HYPH
cord-305263-fgwf6wy3	207	25	early	early	JJ
cord-305263-fgwf6wy3	207	26	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	207	27	state	state	NN
cord-305263-fgwf6wy3	207	28	Direct	direct	JJ
cord-305263-fgwf6wy3	207	29	action	action	NN
cord-305263-fgwf6wy3	207	30	of	of	IN
cord-305263-fgwf6wy3	207	31	type	type	NN
cord-305263-fgwf6wy3	207	32	I	-PRON-	PRP
cord-305263-fgwf6wy3	207	33	IFN	IFN	NNP
cord-305263-fgwf6wy3	207	34	on	on	IN
cord-305263-fgwf6wy3	207	35	NK	NK	NNP
cord-305263-fgwf6wy3	207	36	cells	cell	NNS
cord-305263-fgwf6wy3	207	37	is	be	VBZ
cord-305263-fgwf6wy3	207	38	required	require	VBN
cord-305263-fgwf6wy3	207	39	for	for	IN
cord-305263-fgwf6wy3	207	40	their	-PRON-	PRP$
cord-305263-fgwf6wy3	207	41	activation	activation	NN
cord-305263-fgwf6wy3	207	42	in	in	IN
cord-305263-fgwf6wy3	207	43	response	response	NN
cord-305263-fgwf6wy3	207	44	to	to	IN
cord-305263-fgwf6wy3	207	45	vaccinia	vaccinia	NN
cord-305263-fgwf6wy3	207	46	viral	viral	JJ
cord-305263-fgwf6wy3	207	47	infection	infection	NN
cord-305263-fgwf6wy3	207	48	in	in	IN
cord-305263-fgwf6wy3	207	49	vivo	vivo	NNP
cord-305263-fgwf6wy3	207	50	Dendritic	dendritic	JJ
cord-305263-fgwf6wy3	207	51	cells	cell	NNS
cord-305263-fgwf6wy3	207	52	require	require	VBP
cord-305263-fgwf6wy3	207	53	a	a	DT
cord-305263-fgwf6wy3	207	54	systemic	systemic	JJ
cord-305263-fgwf6wy3	207	55	type	type	NN
cord-305263-fgwf6wy3	208	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	208	2	interferon	interferon	VBD
cord-305263-fgwf6wy3	208	3	response	response	NN
cord-305263-fgwf6wy3	208	4	to	to	TO
cord-305263-fgwf6wy3	208	5	mature	mature	VB
cord-305263-fgwf6wy3	208	6	and	and	CC
cord-305263-fgwf6wy3	208	7	induce	induce	VB
cord-305263-fgwf6wy3	208	8	CD4	CD4	NNP
cord-305263-fgwf6wy3	208	9	+	+	CC
cord-305263-fgwf6wy3	208	10	Th1	th1	CD
cord-305263-fgwf6wy3	208	11	immunity	immunity	NN
cord-305263-fgwf6wy3	208	12	with	with	IN
cord-305263-fgwf6wy3	208	13	poly	poly	JJ
cord-305263-fgwf6wy3	208	14	IC	IC	NNP
cord-305263-fgwf6wy3	208	15	as	as	IN
cord-305263-fgwf6wy3	208	16	adjuvant	adjuvant	NN
cord-305263-fgwf6wy3	208	17	Type	type	NN
cord-305263-fgwf6wy3	209	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	209	2	IFN	IFN	NNP
cord-305263-fgwf6wy3	209	3	enhances	enhance	VBZ
cord-305263-fgwf6wy3	209	4	follicular	follicular	JJ
cord-305263-fgwf6wy3	209	5	B	B	NNP
cord-305263-fgwf6wy3	209	6	cell	cell	NN
cord-305263-fgwf6wy3	209	7	contribution	contribution	NN
cord-305263-fgwf6wy3	209	8	to	to	IN
cord-305263-fgwf6wy3	209	9	the	the	DT
cord-305263-fgwf6wy3	209	10	T	T	NNP
cord-305263-fgwf6wy3	209	11	cell	cell	NN
cord-305263-fgwf6wy3	209	12	-	-	HYPH
cord-305263-fgwf6wy3	209	13	independent	independent	JJ
cord-305263-fgwf6wy3	209	14	antibody	antibody	NN
cord-305263-fgwf6wy3	209	15	response	response	NN
cord-305263-fgwf6wy3	210	1	The	the	DT
cord-305263-fgwf6wy3	210	2	dinucleotide	dinucleotide	NN
cord-305263-fgwf6wy3	210	3	microsatellite	microsatellite	JJ
cord-305263-fgwf6wy3	210	4	polymorphism	polymorphism	NN
cord-305263-fgwf6wy3	210	5	of	of	IN
cord-305263-fgwf6wy3	210	6	IFNAR1	IFNAR1	NNP
cord-305263-fgwf6wy3	210	7	gene	gene	NN
cord-305263-fgwf6wy3	210	8	promoter	promoter	NN
cord-305263-fgwf6wy3	210	9	correlates	correlate	VBZ
cord-305263-fgwf6wy3	210	10	with	with	IN
cord-305263-fgwf6wy3	210	11	responsiveness	responsiveness	NN
cord-305263-fgwf6wy3	210	12	of	of	IN
cord-305263-fgwf6wy3	210	13	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	210	14	C	C	NNP
cord-305263-fgwf6wy3	210	15	patients	patient	NNS
cord-305263-fgwf6wy3	210	16	to	to	IN
cord-305263-fgwf6wy3	210	17	interferon	interferon	VB
cord-305263-fgwf6wy3	210	18	Identification	identification	NN
cord-305263-fgwf6wy3	210	19	of	of	IN
cord-305263-fgwf6wy3	210	20	a	a	DT
cord-305263-fgwf6wy3	210	21	single	single	JJ
cord-305263-fgwf6wy3	210	22	nucleotide	nucleotide	JJ
cord-305263-fgwf6wy3	210	23	polymorphism	polymorphism	NN
cord-305263-fgwf6wy3	210	24	in	in	IN
cord-305263-fgwf6wy3	210	25	the	the	DT
cord-305263-fgwf6wy3	210	26	MxA	MxA	NNP
cord-305263-fgwf6wy3	210	27	gene	gene	NN
cord-305263-fgwf6wy3	210	28	promoter	promoter	NN
cord-305263-fgwf6wy3	210	29	(	(	-LRB-
cord-305263-fgwf6wy3	210	30	G	G	NNP
cord-305263-fgwf6wy3	210	31	/	/	SYM
cord-305263-fgwf6wy3	210	32	T	t	NN
cord-305263-fgwf6wy3	210	33	at	at	IN
cord-305263-fgwf6wy3	210	34	nt	nt	RB
cord-305263-fgwf6wy3	210	35	-88	-88	NN
cord-305263-fgwf6wy3	210	36	)	)	-RRB-
cord-305263-fgwf6wy3	211	1	correlated	correlate	VBN
cord-305263-fgwf6wy3	211	2	with	with	IN
cord-305263-fgwf6wy3	211	3	the	the	DT
cord-305263-fgwf6wy3	211	4	response	response	NN
cord-305263-fgwf6wy3	211	5	of	of	IN
cord-305263-fgwf6wy3	211	6	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	211	7	C	C	NNP
cord-305263-fgwf6wy3	211	8	patients	patient	NNS
cord-305263-fgwf6wy3	211	9	to	to	IN
cord-305263-fgwf6wy3	211	10	interferon	interferon	NN
cord-305263-fgwf6wy3	211	11	Polymorphisms	polymorphism	NNS
cord-305263-fgwf6wy3	211	12	of	of	IN
cord-305263-fgwf6wy3	211	13	interferon	interferon	NN
cord-305263-fgwf6wy3	211	14	-	-	HYPH
cord-305263-fgwf6wy3	211	15	inducible	inducible	JJ
cord-305263-fgwf6wy3	211	16	genes	gene	NNS
cord-305263-fgwf6wy3	211	17	OAS	OAS	NNP
cord-305263-fgwf6wy3	211	18	associated	associate	VBN
cord-305263-fgwf6wy3	211	19	with	with	IN
cord-305263-fgwf6wy3	211	20	interferon	interferon	NN
cord-305263-fgwf6wy3	211	21	-	-	:
cord-305263-fgwf6wy3	211	22	a	a	DT
cord-305263-fgwf6wy3	211	23	treatment	treatment	NN
cord-305263-fgwf6wy3	211	24	response	response	NN
cord-305263-fgwf6wy3	211	25	in	in	IN
cord-305263-fgwf6wy3	211	26	chronic	chronic	JJ
cord-305263-fgwf6wy3	211	27	HBV	HBV	NNP
cord-305263-fgwf6wy3	211	28	infection	infection	NN
cord-305263-fgwf6wy3	211	29	Elevated	elevated	JJ
cord-305263-fgwf6wy3	211	30	expression	expression	NN
cord-305263-fgwf6wy3	211	31	and	and	CC
cord-305263-fgwf6wy3	211	32	polymorphisms	polymorphism	NNS
cord-305263-fgwf6wy3	211	33	of	of	IN
cord-305263-fgwf6wy3	211	34	SOCS3	socs3	JJ
cord-305263-fgwf6wy3	211	35	influence	influence	NN
cord-305263-fgwf6wy3	211	36	patient	patient	NN
cord-305263-fgwf6wy3	211	37	response	response	NN
cord-305263-fgwf6wy3	211	38	to	to	IN
cord-305263-fgwf6wy3	211	39	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	211	40	therapy	therapy	NN
cord-305263-fgwf6wy3	211	41	in	in	IN
cord-305263-fgwf6wy3	211	42	chronic	chronic	JJ
cord-305263-fgwf6wy3	211	43	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	211	44	C	c	NN
cord-305263-fgwf6wy3	211	45	Severe	Severe	NNP
cord-305263-fgwf6wy3	211	46	acute	acute	JJ
cord-305263-fgwf6wy3	211	47	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	211	48	syndrome	syndrome	NN
cord-305263-fgwf6wy3	211	49	coronavirus	coronavirus	NN
cord-305263-fgwf6wy3	211	50	nsp1	nsp1	CD
cord-305263-fgwf6wy3	211	51	suppresses	suppress	VBZ
cord-305263-fgwf6wy3	211	52	host	host	NN
cord-305263-fgwf6wy3	211	53	gene	gene	NN
cord-305263-fgwf6wy3	211	54	expression	expression	NN
cord-305263-fgwf6wy3	211	55	,	,	,
cord-305263-fgwf6wy3	211	56	including	include	VBG
cord-305263-fgwf6wy3	211	57	that	that	DT
cord-305263-fgwf6wy3	211	58	of	of	IN
cord-305263-fgwf6wy3	211	59	type	type	NN
cord-305263-fgwf6wy3	212	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	212	2	interferon	interferon	VBD
cord-305263-fgwf6wy3	212	3	,	,	,
cord-305263-fgwf6wy3	212	4	in	in	IN
cord-305263-fgwf6wy3	212	5	infected	infected	JJ
cord-305263-fgwf6wy3	212	6	cells	cell	NNS
cord-305263-fgwf6wy3	213	1	The	the	DT
cord-305263-fgwf6wy3	213	2	multifunctional	multifunctional	JJ
cord-305263-fgwf6wy3	213	3	NS1	ns1	NN
cord-305263-fgwf6wy3	213	4	protein	protein	NN
cord-305263-fgwf6wy3	213	5	of	of	IN
cord-305263-fgwf6wy3	213	6	influenza	influenza	NN
cord-305263-fgwf6wy3	213	7	A	a	DT
cord-305263-fgwf6wy3	213	8	viruses	virus	NNS
cord-305263-fgwf6wy3	214	1	MAVS	MAVS	NNP
cord-305263-fgwf6wy3	214	2	dimer	dimer	NNP
cord-305263-fgwf6wy3	214	3	is	be	VBZ
cord-305263-fgwf6wy3	214	4	a	a	DT
cord-305263-fgwf6wy3	214	5	crucial	crucial	JJ
cord-305263-fgwf6wy3	214	6	signaling	signal	VBG
cord-305263-fgwf6wy3	214	7	component	component	NN
cord-305263-fgwf6wy3	214	8	of	of	IN
cord-305263-fgwf6wy3	214	9	innate	innate	JJ
cord-305263-fgwf6wy3	214	10	immunity	immunity	NN
cord-305263-fgwf6wy3	214	11	and	and	CC
cord-305263-fgwf6wy3	214	12	the	the	DT
cord-305263-fgwf6wy3	214	13	target	target	NN
cord-305263-fgwf6wy3	214	14	of	of	IN
cord-305263-fgwf6wy3	214	15	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	214	16	C	C	NNP
cord-305263-fgwf6wy3	214	17	virus	virus	NN
cord-305263-fgwf6wy3	214	18	NS3/4A	ns3/4a	NN
cord-305263-fgwf6wy3	214	19	protease	protease	NN
cord-305263-fgwf6wy3	214	20	Hepatitis	Hepatitis	NNP
cord-305263-fgwf6wy3	214	21	B	B	NNP
cord-305263-fgwf6wy3	214	22	virus	virus	NN
cord-305263-fgwf6wy3	214	23	polymerase	polymerase	NN
cord-305263-fgwf6wy3	214	24	blocks	block	NNS
cord-305263-fgwf6wy3	214	25	pattern	pattern	NN
cord-305263-fgwf6wy3	214	26	recognition	recognition	NN
cord-305263-fgwf6wy3	214	27	receptor	receptor	NN
cord-305263-fgwf6wy3	214	28	signaling	signal	VBG
cord-305263-fgwf6wy3	214	29	via	via	IN
cord-305263-fgwf6wy3	214	30	interaction	interaction	NN
cord-305263-fgwf6wy3	214	31	with	with	IN
cord-305263-fgwf6wy3	214	32	DDX3	DDX3	NNP
cord-305263-fgwf6wy3	214	33	:	:	:
cord-305263-fgwf6wy3	214	34	implications	implication	NNS
cord-305263-fgwf6wy3	214	35	for	for	IN
cord-305263-fgwf6wy3	214	36	immune	immune	JJ
cord-305263-fgwf6wy3	214	37	evasion	evasion	NN
cord-305263-fgwf6wy3	215	1	Cellular	cellular	JJ
cord-305263-fgwf6wy3	215	2	localization	localization	NN
cord-305263-fgwf6wy3	215	3	of	of	IN
cord-305263-fgwf6wy3	215	4	the	the	DT
cord-305263-fgwf6wy3	215	5	herpes	herpes	NNP
cord-305263-fgwf6wy3	215	6	simplex	simplex	NNP
cord-305263-fgwf6wy3	215	7	virus	virus	NN
cord-305263-fgwf6wy3	215	8	ICP0	ICP0	NNP
cord-305263-fgwf6wy3	215	9	protein	protein	NN
cord-305263-fgwf6wy3	215	10	dictates	dictate	VBZ
cord-305263-fgwf6wy3	215	11	its	-PRON-	PRP$
cord-305263-fgwf6wy3	215	12	ability	ability	NN
cord-305263-fgwf6wy3	215	13	to	to	TO
cord-305263-fgwf6wy3	215	14	block	block	VB
cord-305263-fgwf6wy3	215	15	IRF3-mediated	irf3-mediate	VBN
cord-305263-fgwf6wy3	215	16	innate	innate	JJ
cord-305263-fgwf6wy3	215	17	immune	immune	JJ
cord-305263-fgwf6wy3	215	18	responses	response	NNS
cord-305263-fgwf6wy3	215	19	Severe	severe	JJ
cord-305263-fgwf6wy3	215	20	acute	acute	JJ
cord-305263-fgwf6wy3	215	21	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	215	22	syndrome	syndrome	NN
cord-305263-fgwf6wy3	215	23	coronavirus	coronavirus	NN
cord-305263-fgwf6wy3	215	24	ORF6	ORF6	NNP
cord-305263-fgwf6wy3	215	25	antagonizes	antagonize	VBZ
cord-305263-fgwf6wy3	215	26	STAT1	stat1	NN
cord-305263-fgwf6wy3	215	27	function	function	NN
cord-305263-fgwf6wy3	215	28	by	by	IN
cord-305263-fgwf6wy3	215	29	sequestering	sequester	VBG
cord-305263-fgwf6wy3	215	30	nuclear	nuclear	JJ
cord-305263-fgwf6wy3	215	31	import	import	NN
cord-305263-fgwf6wy3	215	32	factors	factor	NNS
cord-305263-fgwf6wy3	215	33	on	on	IN
cord-305263-fgwf6wy3	215	34	the	the	DT
cord-305263-fgwf6wy3	215	35	rough	rough	JJ
cord-305263-fgwf6wy3	215	36	endoplasmic	endoplasmic	NN
cord-305263-fgwf6wy3	215	37	reticulum	reticulum	NN
cord-305263-fgwf6wy3	215	38	/	/	SYM
cord-305263-fgwf6wy3	215	39	Golgi	Golgi	NNP
cord-305263-fgwf6wy3	215	40	membrane	membrane	NN
cord-305263-fgwf6wy3	215	41	Influenza	Influenza	NNP
cord-305263-fgwf6wy3	215	42	virus	virus	NN
cord-305263-fgwf6wy3	215	43	non	non	JJ
cord-305263-fgwf6wy3	215	44	-	-	JJ
cord-305263-fgwf6wy3	215	45	structural	structural	JJ
cord-305263-fgwf6wy3	215	46	protein	protein	NN
cord-305263-fgwf6wy3	215	47	1	1	CD
cord-305263-fgwf6wy3	215	48	(	(	-LRB-
cord-305263-fgwf6wy3	215	49	NS1	NS1	NNS
cord-305263-fgwf6wy3	215	50	)	)	-RRB-
cord-305263-fgwf6wy3	215	51	disrupts	disrupt	VBZ
cord-305263-fgwf6wy3	215	52	interferon	interferon	NN
cord-305263-fgwf6wy3	215	53	signaling	signal	VBG
cord-305263-fgwf6wy3	215	54	Role	role	NN
cord-305263-fgwf6wy3	215	55	for	for	IN
cord-305263-fgwf6wy3	215	56	herpes	herpes	NN
cord-305263-fgwf6wy3	215	57	simplex	simplex	NNP
cord-305263-fgwf6wy3	215	58	virus	virus	NN
cord-305263-fgwf6wy3	215	59	1	1	CD
cord-305263-fgwf6wy3	215	60	ICP27	ICP27	NNP
cord-305263-fgwf6wy3	215	61	in	in	IN
cord-305263-fgwf6wy3	215	62	the	the	DT
cord-305263-fgwf6wy3	215	63	inhibition	inhibition	NN
cord-305263-fgwf6wy3	215	64	of	of	IN
cord-305263-fgwf6wy3	215	65	type	type	NN
cord-305263-fgwf6wy3	216	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	216	2	interferon	interferon	RB
cord-305263-fgwf6wy3	216	3	signaling	signal	VBG
cord-305263-fgwf6wy3	216	4	A	a	DT
cord-305263-fgwf6wy3	216	5	two	two	CD
cord-305263-fgwf6wy3	216	6	-	-	HYPH
cord-305263-fgwf6wy3	216	7	pronged	pronged	JJ
cord-305263-fgwf6wy3	216	8	strategy	strategy	NN
cord-305263-fgwf6wy3	216	9	to	to	TO
cord-305263-fgwf6wy3	216	10	suppress	suppress	VB
cord-305263-fgwf6wy3	216	11	host	host	NN
cord-305263-fgwf6wy3	216	12	protein	protein	NN
cord-305263-fgwf6wy3	216	13	synthesis	synthesis	NN
cord-305263-fgwf6wy3	216	14	by	by	IN
cord-305263-fgwf6wy3	216	15	SARS	SARS	NNP
cord-305263-fgwf6wy3	216	16	coronavirus	coronavirus	NN
cord-305263-fgwf6wy3	217	1	Nsp1	nsp1	NN
cord-305263-fgwf6wy3	217	2	protein	protein	NN
cord-305263-fgwf6wy3	217	3	Severe	severe	JJ
cord-305263-fgwf6wy3	217	4	acute	acute	JJ
cord-305263-fgwf6wy3	217	5	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	217	6	syndrome	syndrome	NN
cord-305263-fgwf6wy3	217	7	coronavirus	coronavirus	NN
cord-305263-fgwf6wy3	217	8	evades	evade	VBZ
cord-305263-fgwf6wy3	217	9	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	217	10	signaling	signaling	NN
cord-305263-fgwf6wy3	217	11	:	:	:
cord-305263-fgwf6wy3	217	12	role	role	NN
cord-305263-fgwf6wy3	217	13	of	of	IN
cord-305263-fgwf6wy3	217	14	nsp1	nsp1	NNS
cord-305263-fgwf6wy3	217	15	and	and	CC
cord-305263-fgwf6wy3	217	16	rational	rational	JJ
cord-305263-fgwf6wy3	217	17	design	design	NN
cord-305263-fgwf6wy3	217	18	of	of	IN
cord-305263-fgwf6wy3	217	19	an	an	DT
cord-305263-fgwf6wy3	217	20	attenuated	attenuated	JJ
cord-305263-fgwf6wy3	217	21	strain	strain	NN
cord-305263-fgwf6wy3	217	22	Regulation	regulation	NN
cord-305263-fgwf6wy3	217	23	of	of	IN
cord-305263-fgwf6wy3	217	24	IRF-3-dependent	irf-3-dependent	JJ
cord-305263-fgwf6wy3	217	25	innate	innate	JJ
cord-305263-fgwf6wy3	217	26	immunity	immunity	NN
cord-305263-fgwf6wy3	217	27	by	by	IN
cord-305263-fgwf6wy3	217	28	the	the	DT
cord-305263-fgwf6wy3	217	29	papain	papain	NN
cord-305263-fgwf6wy3	217	30	-	-	HYPH
cord-305263-fgwf6wy3	217	31	like	like	JJ
cord-305263-fgwf6wy3	217	32	protease	protease	NN
cord-305263-fgwf6wy3	217	33	domain	domain	NN
cord-305263-fgwf6wy3	217	34	of	of	IN
cord-305263-fgwf6wy3	217	35	the	the	DT
cord-305263-fgwf6wy3	217	36	severe	severe	JJ
cord-305263-fgwf6wy3	217	37	acute	acute	JJ
cord-305263-fgwf6wy3	217	38	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	217	39	syndrome	syndrome	NN
cord-305263-fgwf6wy3	217	40	coronavirus	coronavirus	NN
cord-305263-fgwf6wy3	218	1	Severe	severe	JJ
cord-305263-fgwf6wy3	218	2	acute	acute	JJ
cord-305263-fgwf6wy3	218	3	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	218	4	syndrome	syndrome	NN
cord-305263-fgwf6wy3	218	5	coronavirus	coronavirus	NN
cord-305263-fgwf6wy3	218	6	M	M	NNP
cord-305263-fgwf6wy3	218	7	protein	protein	NN
cord-305263-fgwf6wy3	218	8	inhibits	inhibit	VBZ
cord-305263-fgwf6wy3	218	9	type	type	NN
cord-305263-fgwf6wy3	219	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	220	1	interferon	interferon	NN
cord-305263-fgwf6wy3	220	2	production	production	NN
cord-305263-fgwf6wy3	220	3	by	by	IN
cord-305263-fgwf6wy3	220	4	impeding	impede	VBG
cord-305263-fgwf6wy3	220	5	the	the	DT
cord-305263-fgwf6wy3	220	6	formation	formation	NN
cord-305263-fgwf6wy3	220	7	of	of	IN
cord-305263-fgwf6wy3	220	8	TRAF3.TANK.TBK1	TRAF3.TANK.TBK1	NNP
cord-305263-fgwf6wy3	220	9	/	/	SYM
cord-305263-fgwf6wy3	220	10	IKKepsilon	IKKepsilon	NNP
cord-305263-fgwf6wy3	220	11	complex	complex	JJ
cord-305263-fgwf6wy3	220	12	Clinical	clinical	JJ
cord-305263-fgwf6wy3	220	13	application	application	NN
cord-305263-fgwf6wy3	220	14	of	of	IN
cord-305263-fgwf6wy3	220	15	interferons	interferon	NNS
cord-305263-fgwf6wy3	221	1	Interferon	interferon	NN
cord-305263-fgwf6wy3	221	2	:	:	:
cord-305263-fgwf6wy3	221	3	current	current	JJ
cord-305263-fgwf6wy3	221	4	status	status	NN
cord-305263-fgwf6wy3	221	5	and	and	CC
cord-305263-fgwf6wy3	221	6	future	future	JJ
cord-305263-fgwf6wy3	221	7	prospects	prospect	NNS
cord-305263-fgwf6wy3	221	8	in	in	IN
cord-305263-fgwf6wy3	221	9	cancer	cancer	NN
cord-305263-fgwf6wy3	221	10	therapy	therapy	NN
cord-305263-fgwf6wy3	221	11	Definition	definition	NN
cord-305263-fgwf6wy3	221	12	of	of	IN
cord-305263-fgwf6wy3	221	13	receptor	receptor	NN
cord-305263-fgwf6wy3	221	14	binding	bind	VBG
cord-305263-fgwf6wy3	221	15	domains	domain	NNS
cord-305263-fgwf6wy3	221	16	in	in	IN
cord-305263-fgwf6wy3	221	17	interferonalpha	interferonalpha	NNP
cord-305263-fgwf6wy3	221	18	A	a	DT
cord-305263-fgwf6wy3	221	19	three	three	CD
cord-305263-fgwf6wy3	221	20	-	-	HYPH
cord-305263-fgwf6wy3	221	21	dimensional	dimensional	JJ
cord-305263-fgwf6wy3	221	22	model	model	NN
cord-305263-fgwf6wy3	221	23	of	of	IN
cord-305263-fgwf6wy3	221	24	consensus	consensus	NN
cord-305263-fgwf6wy3	221	25	sequence	sequence	NN
cord-305263-fgwf6wy3	221	26	interferon	interferon	NN
cord-305263-fgwf6wy3	221	27	-	-	HYPH
cord-305263-fgwf6wy3	221	28	alpha	alpha	NN
cord-305263-fgwf6wy3	221	29	Domains	domain	NNS
cord-305263-fgwf6wy3	221	30	of	of	IN
cord-305263-fgwf6wy3	221	31	interaction	interaction	NN
cord-305263-fgwf6wy3	221	32	between	between	IN
cord-305263-fgwf6wy3	221	33	alpha	alpha	NN
cord-305263-fgwf6wy3	221	34	interferon	interferon	NN
cord-305263-fgwf6wy3	221	35	and	and	CC
cord-305263-fgwf6wy3	221	36	its	-PRON-	PRP$
cord-305263-fgwf6wy3	221	37	receptor	receptor	NN
cord-305263-fgwf6wy3	221	38	components	component	NNS
cord-305263-fgwf6wy3	221	39	Mutational	Mutational	NNP
cord-305263-fgwf6wy3	221	40	and	and	CC
cord-305263-fgwf6wy3	221	41	structural	structural	JJ
cord-305263-fgwf6wy3	221	42	analysis	analysis	NN
cord-305263-fgwf6wy3	221	43	of	of	IN
cord-305263-fgwf6wy3	221	44	the	the	DT
cord-305263-fgwf6wy3	221	45	binding	bind	VBG
cord-305263-fgwf6wy3	221	46	interface	interface	NN
cord-305263-fgwf6wy3	221	47	between	between	IN
cord-305263-fgwf6wy3	221	48	type	type	NN
cord-305263-fgwf6wy3	221	49	I	-PRON-	PRP
cord-305263-fgwf6wy3	221	50	interferons	interferon	NNS
cord-305263-fgwf6wy3	221	51	and	and	CC
cord-305263-fgwf6wy3	221	52	their	-PRON-	PRP$
cord-305263-fgwf6wy3	221	53	receptor	receptor	NN
cord-305263-fgwf6wy3	221	54	Ifnar2	Ifnar2	NNP
cord-305263-fgwf6wy3	221	55	Mapping	Mapping	NNP
cord-305263-fgwf6wy3	221	56	of	of	IN
cord-305263-fgwf6wy3	221	57	IFN	IFN	NNP
cord-305263-fgwf6wy3	221	58	-	-	HYPH
cord-305263-fgwf6wy3	221	59	beta	beta	NN
cord-305263-fgwf6wy3	221	60	epitopes	epitope	NNS
cord-305263-fgwf6wy3	221	61	important	important	JJ
cord-305263-fgwf6wy3	221	62	for	for	IN
cord-305263-fgwf6wy3	221	63	receptor	receptor	NN
cord-305263-fgwf6wy3	221	64	binding	binding	NN
cord-305263-fgwf6wy3	221	65	and	and	CC
cord-305263-fgwf6wy3	221	66	biologic	biologic	JJ
cord-305263-fgwf6wy3	221	67	activation	activation	NN
cord-305263-fgwf6wy3	221	68	:	:	:
cord-305263-fgwf6wy3	221	69	comparison	comparison	NN
cord-305263-fgwf6wy3	221	70	of	of	IN
cord-305263-fgwf6wy3	221	71	results	result	NNS
cord-305263-fgwf6wy3	221	72	achieved	achieve	VBN
cord-305263-fgwf6wy3	221	73	using	use	VBG
cord-305263-fgwf6wy3	221	74	antibody	antibody	NN
cord-305263-fgwf6wy3	221	75	-	-	HYPH
cord-305263-fgwf6wy3	221	76	based	base	VBN
cord-305263-fgwf6wy3	221	77	methods	method	NNS
cord-305263-fgwf6wy3	221	78	and	and	CC
cord-305263-fgwf6wy3	221	79	alanine	alanine	NN
cord-305263-fgwf6wy3	221	80	substitution	substitution	NN
cord-305263-fgwf6wy3	221	81	mutagenesis	mutagenesis	NN
cord-305263-fgwf6wy3	221	82	Interferon	Interferon	NNP
cord-305263-fgwf6wy3	221	83	-	-	HYPH
cord-305263-fgwf6wy3	221	84	a	a	NN
cord-305263-fgwf6wy3	221	85	/	/	SYM
cord-305263-fgwf6wy3	221	86	b	b	NN
cord-305263-fgwf6wy3	221	87	-	-	HYPH
cord-305263-fgwf6wy3	221	88	receptor	receptor	NN
cord-305263-fgwf6wy3	221	89	interactions	interaction	NNS
cord-305263-fgwf6wy3	221	90	:	:	:
cord-305263-fgwf6wy3	222	1	a	a	DT
cord-305263-fgwf6wy3	222	2	complex	complex	JJ
cord-305263-fgwf6wy3	222	3	story	story	NN
cord-305263-fgwf6wy3	222	4	unfolding	unfold	VBG
cord-305263-fgwf6wy3	222	5	Mutational	Mutational	NNP
cord-305263-fgwf6wy3	222	6	analysis	analysis	NN
cord-305263-fgwf6wy3	222	7	of	of	IN
cord-305263-fgwf6wy3	222	8	the	the	DT
cord-305263-fgwf6wy3	222	9	IFNAR1	ifnar1	NN
cord-305263-fgwf6wy3	222	10	binding	bind	VBG
cord-305263-fgwf6wy3	222	11	site	site	NN
cord-305263-fgwf6wy3	222	12	on	on	IN
cord-305263-fgwf6wy3	222	13	IFNa2	IFNa2	NNP
cord-305263-fgwf6wy3	222	14	reveals	reveal	VBZ
cord-305263-fgwf6wy3	222	15	the	the	DT
cord-305263-fgwf6wy3	222	16	architecture	architecture	NN
cord-305263-fgwf6wy3	222	17	of	of	IN
cord-305263-fgwf6wy3	222	18	a	a	DT
cord-305263-fgwf6wy3	222	19	weak	weak	JJ
cord-305263-fgwf6wy3	222	20	ligand	ligand	NN
cord-305263-fgwf6wy3	222	21	-	-	HYPH
cord-305263-fgwf6wy3	222	22	receptor	receptor	NN
cord-305263-fgwf6wy3	222	23	binding	binding	NN
cord-305263-fgwf6wy3	222	24	site	site	NN
cord-305263-fgwf6wy3	223	1	The	the	DT
cord-305263-fgwf6wy3	223	2	human	human	JJ
cord-305263-fgwf6wy3	223	3	type	type	NN
cord-305263-fgwf6wy3	224	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	224	2	interferon	interferon	VBD
cord-305263-fgwf6wy3	224	3	receptor	receptor	NN
cord-305263-fgwf6wy3	224	4	:	:	:
cord-305263-fgwf6wy3	224	5	NMR	NMR	NNP
cord-305263-fgwf6wy3	224	6	structure	structure	NN
cord-305263-fgwf6wy3	224	7	reveals	reveal	VBZ
cord-305263-fgwf6wy3	224	8	the	the	DT
cord-305263-fgwf6wy3	224	9	molecular	molecular	JJ
cord-305263-fgwf6wy3	224	10	basis	basis	NN
cord-305263-fgwf6wy3	224	11	of	of	IN
cord-305263-fgwf6wy3	224	12	ligand	ligand	NN
cord-305263-fgwf6wy3	224	13	binding	bind	VBG
cord-305263-fgwf6wy3	224	14	Mutation	Mutation	NNP
cord-305263-fgwf6wy3	224	15	of	of	IN
cord-305263-fgwf6wy3	224	16	the	the	DT
cord-305263-fgwf6wy3	224	17	IFNAR-1	IFNAR-1	NNP
cord-305263-fgwf6wy3	224	18	receptor	receptor	NN
cord-305263-fgwf6wy3	224	19	binding	binding	NN
cord-305263-fgwf6wy3	224	20	site	site	NN
cord-305263-fgwf6wy3	224	21	of	of	IN
cord-305263-fgwf6wy3	224	22	human	human	JJ
cord-305263-fgwf6wy3	224	23	IFN	IFN	NNP
cord-305263-fgwf6wy3	224	24	-	-	HYPH
cord-305263-fgwf6wy3	224	25	alpha2	alpha2	NN
cord-305263-fgwf6wy3	224	26	generates	generate	VBZ
cord-305263-fgwf6wy3	224	27	type	type	NN
cord-305263-fgwf6wy3	225	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	225	2	IFN	IFN	NNP
cord-305263-fgwf6wy3	225	3	competitive	competitive	JJ
cord-305263-fgwf6wy3	225	4	antagonists	antagonist	NNS
cord-305263-fgwf6wy3	225	5	Human	human	JJ
cord-305263-fgwf6wy3	225	6	leukocyte	leukocyte	NN
cord-305263-fgwf6wy3	225	7	interferon	interferon	NN
cord-305263-fgwf6wy3	225	8	subtypes	subtype	NNS
cord-305263-fgwf6wy3	225	9	have	have	VBP
cord-305263-fgwf6wy3	225	10	different	different	JJ
cord-305263-fgwf6wy3	225	11	antiproliferative	antiproliferative	JJ
cord-305263-fgwf6wy3	225	12	and	and	CC
cord-305263-fgwf6wy3	225	13	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	225	14	activities	activity	NNS
cord-305263-fgwf6wy3	225	15	on	on	IN
cord-305263-fgwf6wy3	225	16	human	human	JJ
cord-305263-fgwf6wy3	225	17	cells	cell	NNS
cord-305263-fgwf6wy3	226	1	The	the	DT
cord-305263-fgwf6wy3	226	2	role	role	NN
cord-305263-fgwf6wy3	226	3	of	of	IN
cord-305263-fgwf6wy3	226	4	three	three	CD
cord-305263-fgwf6wy3	226	5	domains	domain	NNS
cord-305263-fgwf6wy3	226	6	in	in	IN
cord-305263-fgwf6wy3	226	7	the	the	DT
cord-305263-fgwf6wy3	226	8	biologically	biologically	RB
cord-305263-fgwf6wy3	226	9	active	active	JJ
cord-305263-fgwf6wy3	226	10	configuration	configuration	NN
cord-305263-fgwf6wy3	226	11	of	of	IN
cord-305263-fgwf6wy3	226	12	human	human	JJ
cord-305263-fgwf6wy3	226	13	interferon	interferon	NNP
cord-305263-fgwf6wy3	226	14	alpha	alpha	NN
cord-305263-fgwf6wy3	226	15	Structural	structural	JJ
cord-305263-fgwf6wy3	226	16	linkage	linkage	NN
cord-305263-fgwf6wy3	226	17	between	between	IN
cord-305263-fgwf6wy3	226	18	ligand	ligand	NN
cord-305263-fgwf6wy3	226	19	discrimination	discrimination	NN
cord-305263-fgwf6wy3	226	20	and	and	CC
cord-305263-fgwf6wy3	226	21	receptor	receptor	NN
cord-305263-fgwf6wy3	226	22	activation	activation	NN
cord-305263-fgwf6wy3	226	23	by	by	IN
cord-305263-fgwf6wy3	226	24	type	type	NN
cord-305263-fgwf6wy3	227	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	227	2	interferons	interferon	NNS
cord-305263-fgwf6wy3	228	1	Interferon	interferon	NN
cord-305263-fgwf6wy3	228	2	alfacon	alfacon	NN
cord-305263-fgwf6wy3	228	3	1	1	CD
cord-305263-fgwf6wy3	228	4	inhibits	inhibit	VBZ
cord-305263-fgwf6wy3	228	5	SARS	SARS	NNP
cord-305263-fgwf6wy3	228	6	-	-	HYPH
cord-305263-fgwf6wy3	228	7	CoV	cov	NN
cord-305263-fgwf6wy3	228	8	infection	infection	NN
cord-305263-fgwf6wy3	228	9	in	in	IN
cord-305263-fgwf6wy3	228	10	human	human	JJ
cord-305263-fgwf6wy3	228	11	bronchial	bronchial	JJ
cord-305263-fgwf6wy3	228	12	epithelial	epithelial	JJ
cord-305263-fgwf6wy3	228	13	Calu-3	Calu-3	NNP
cord-305263-fgwf6wy3	228	14	cells	cell	NNS
cord-305263-fgwf6wy3	228	15	Interferon	Interferon	NNP
cord-305263-fgwf6wy3	228	16	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	228	17	and	and	CC
cord-305263-fgwf6wy3	228	18	ribavirin	ribavirin	RB
cord-305263-fgwf6wy3	228	19	versus	versus	IN
cord-305263-fgwf6wy3	228	20	interferon	interferon	NN
cord-305263-fgwf6wy3	228	21	alpha-2b	alpha-2b	NNP
cord-305263-fgwf6wy3	228	22	and	and	CC
cord-305263-fgwf6wy3	228	23	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	228	24	in	in	IN
cord-305263-fgwf6wy3	228	25	the	the	DT
cord-305263-fgwf6wy3	228	26	treatment	treatment	NN
cord-305263-fgwf6wy3	228	27	of	of	IN
cord-305263-fgwf6wy3	228	28	chronic	chronic	JJ
cord-305263-fgwf6wy3	228	29	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	228	30	C	c	NN
cord-305263-fgwf6wy3	229	1	Interferon	Interferon	NNP
cord-305263-fgwf6wy3	229	2	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	229	3	:	:	:
cord-305263-fgwf6wy3	229	4	a	a	DT
cord-305263-fgwf6wy3	229	5	review	review	NN
cord-305263-fgwf6wy3	229	6	of	of	IN
cord-305263-fgwf6wy3	229	7	its	-PRON-	PRP$
cord-305263-fgwf6wy3	229	8	pharmacology	pharmacology	NN
cord-305263-fgwf6wy3	229	9	and	and	CC
cord-305263-fgwf6wy3	229	10	therapeutic	therapeutic	JJ
cord-305263-fgwf6wy3	229	11	efficacy	efficacy	NN
cord-305263-fgwf6wy3	229	12	in	in	IN
cord-305263-fgwf6wy3	229	13	the	the	DT
cord-305263-fgwf6wy3	229	14	treatment	treatment	NN
cord-305263-fgwf6wy3	229	15	of	of	IN
cord-305263-fgwf6wy3	229	16	chronic	chronic	JJ
cord-305263-fgwf6wy3	229	17	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	229	18	C	c	NN
cord-305263-fgwf6wy3	230	1	The	the	DT
cord-305263-fgwf6wy3	230	2	biologic	biologic	JJ
cord-305263-fgwf6wy3	230	3	activity	activity	NN
cord-305263-fgwf6wy3	230	4	and	and	CC
cord-305263-fgwf6wy3	230	5	molecular	molecular	JJ
cord-305263-fgwf6wy3	230	6	characterization	characterization	NN
cord-305263-fgwf6wy3	230	7	of	of	IN
cord-305263-fgwf6wy3	230	8	a	a	DT
cord-305263-fgwf6wy3	230	9	novel	novel	JJ
cord-305263-fgwf6wy3	230	10	synthetic	synthetic	JJ
cord-305263-fgwf6wy3	230	11	interferon	interferon	NN
cord-305263-fgwf6wy3	230	12	-	-	HYPH
cord-305263-fgwf6wy3	230	13	alpha	alpha	NN
cord-305263-fgwf6wy3	230	14	species	specie	NNS
cord-305263-fgwf6wy3	230	15	,	,	,
cord-305263-fgwf6wy3	230	16	consensus	consensus	NN
cord-305263-fgwf6wy3	230	17	interferon	interferon	NN
cord-305263-fgwf6wy3	230	18	SARS	SARS	NNP
cord-305263-fgwf6wy3	230	19	:	:	:
cord-305263-fgwf6wy3	230	20	systemic	systemic	JJ
cord-305263-fgwf6wy3	230	21	review	review	NN
cord-305263-fgwf6wy3	230	22	of	of	IN
cord-305263-fgwf6wy3	230	23	treatment	treatment	NN
cord-305263-fgwf6wy3	230	24	effects	effect	NNS
cord-305263-fgwf6wy3	230	25	Identification	identification	NN
cord-305263-fgwf6wy3	230	26	of	of	IN
cord-305263-fgwf6wy3	230	27	severe	severe	JJ
cord-305263-fgwf6wy3	230	28	acute	acute	JJ
cord-305263-fgwf6wy3	230	29	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	230	30	syndrome	syndrome	NN
cord-305263-fgwf6wy3	230	31	in	in	IN
cord-305263-fgwf6wy3	230	32	Canada	Canada	NNP
cord-305263-fgwf6wy3	231	1	Interferon	interferon	NN
cord-305263-fgwf6wy3	231	2	alfacon-1	alfacon-1	NNP
cord-305263-fgwf6wy3	231	3	plus	plus	CC
cord-305263-fgwf6wy3	231	4	corticosteroids	corticosteroid	NNS
cord-305263-fgwf6wy3	231	5	in	in	IN
cord-305263-fgwf6wy3	231	6	severe	severe	JJ
cord-305263-fgwf6wy3	231	7	acute	acute	JJ
cord-305263-fgwf6wy3	231	8	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	231	9	syndrome	syndrome	NN
cord-305263-fgwf6wy3	231	10	Characterization	characterization	NN
cord-305263-fgwf6wy3	231	11	of	of	IN
cord-305263-fgwf6wy3	231	12	the	the	DT
cord-305263-fgwf6wy3	231	13	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	231	14	effects	effect	NNS
cord-305263-fgwf6wy3	231	15	of	of	IN
cord-305263-fgwf6wy3	231	16	interferon	interferon	NN
cord-305263-fgwf6wy3	231	17	-	-	HYPH
cord-305263-fgwf6wy3	231	18	alpha	alpha	NN
cord-305263-fgwf6wy3	231	19	against	against	IN
cord-305263-fgwf6wy3	231	20	a	a	DT
cord-305263-fgwf6wy3	231	21	SARS	SARS	NNP
cord-305263-fgwf6wy3	231	22	-	-	HYPH
cord-305263-fgwf6wy3	231	23	like	like	JJ
cord-305263-fgwf6wy3	231	24	Coronavirus	Coronavirus	NNP
cord-305263-fgwf6wy3	231	25	infection	infection	NN
cord-305263-fgwf6wy3	232	1	in	in	IN
cord-305263-fgwf6wy3	232	2	vitro	vitro	FW
cord-305263-fgwf6wy3	233	1	The	the	DT
cord-305263-fgwf6wy3	233	2	potential	potential	NN
cord-305263-fgwf6wy3	233	3	for	for	IN
cord-305263-fgwf6wy3	233	4	multidrug	multidrug	NN
cord-305263-fgwf6wy3	233	5	-	-	HYPH
cord-305263-fgwf6wy3	233	6	resistant	resistant	JJ
cord-305263-fgwf6wy3	233	7	influenza	influenza	NN
cord-305263-fgwf6wy3	233	8	Oseltamivir	Oseltamivir	NNP
cord-305263-fgwf6wy3	233	9	-	-	HYPH
cord-305263-fgwf6wy3	233	10	resistant	resistant	JJ
cord-305263-fgwf6wy3	233	11	pandemic	pandemic	NN
cord-305263-fgwf6wy3	233	12	(	(	-LRB-
cord-305263-fgwf6wy3	233	13	H1N1	H1N1	NNP
cord-305263-fgwf6wy3	233	14	)	)	-RRB-
cord-305263-fgwf6wy3	233	15	2009	2009	CD
cord-305263-fgwf6wy3	233	16	virus	virus	NN
cord-305263-fgwf6wy3	233	17	infection	infection	NN
cord-305263-fgwf6wy3	233	18	in	in	IN
cord-305263-fgwf6wy3	233	19	England	England	NNP
cord-305263-fgwf6wy3	233	20	and	and	CC
cord-305263-fgwf6wy3	233	21	Scotland	Scotland	NNP
cord-305263-fgwf6wy3	233	22	Avian	avian	JJ
cord-305263-fgwf6wy3	233	23	influenza	influenza	NN
cord-305263-fgwf6wy3	233	24	A(H5N1	A(H5N1	NNP
cord-305263-fgwf6wy3	233	25	)	)	-RRB-
cord-305263-fgwf6wy3	233	26	in	in	IN
cord-305263-fgwf6wy3	233	27	humans	human	NNS
cord-305263-fgwf6wy3	233	28	:	:	:
cord-305263-fgwf6wy3	233	29	new	new	JJ
cord-305263-fgwf6wy3	233	30	insights	insight	NNS
cord-305263-fgwf6wy3	233	31	from	from	IN
cord-305263-fgwf6wy3	233	32	a	a	DT
cord-305263-fgwf6wy3	233	33	line	line	NN
cord-305263-fgwf6wy3	233	34	list	list	NN
cord-305263-fgwf6wy3	233	35	of	of	IN
cord-305263-fgwf6wy3	233	36	World	World	NNP
cord-305263-fgwf6wy3	233	37	Health	Health	NNP
cord-305263-fgwf6wy3	233	38	Organization	Organization	NNP
cord-305263-fgwf6wy3	233	39	confirmed	confirm	VBD
cord-305263-fgwf6wy3	233	40	cases	case	NNS
cord-305263-fgwf6wy3	234	1	Oseltamivir	Oseltamivir	NNP
cord-305263-fgwf6wy3	234	2	resistance	resistance	NN
cord-305263-fgwf6wy3	234	3	during	during	IN
cord-305263-fgwf6wy3	234	4	treatment	treatment	NN
cord-305263-fgwf6wy3	234	5	of	of	IN
cord-305263-fgwf6wy3	234	6	influenza	influenza	NN
cord-305263-fgwf6wy3	234	7	A	a	NN
cord-305263-fgwf6wy3	234	8	(	(	-LRB-
cord-305263-fgwf6wy3	234	9	H5N1	H5N1	NNP
cord-305263-fgwf6wy3	234	10	)	)	-RRB-
cord-305263-fgwf6wy3	234	11	infection	infection	NN
cord-305263-fgwf6wy3	235	1	A	a	DT
cord-305263-fgwf6wy3	235	2	randomized	randomized	JJ
cord-305263-fgwf6wy3	235	3	controlled	control	VBN
cord-305263-fgwf6wy3	235	4	trial	trial	NN
cord-305263-fgwf6wy3	235	5	of	of	IN
cord-305263-fgwf6wy3	235	6	low	low	JJ
cord-305263-fgwf6wy3	235	7	-	-	HYPH
cord-305263-fgwf6wy3	235	8	dose	dose	NN
cord-305263-fgwf6wy3	235	9	recombinant	recombinant	JJ
cord-305263-fgwf6wy3	235	10	human	human	NN
cord-305263-fgwf6wy3	235	11	interferon	interferon	NN
cord-305263-fgwf6wy3	235	12	alpha-2b	alpha-2b	NNP
cord-305263-fgwf6wy3	235	13	nasal	nasal	NN
cord-305263-fgwf6wy3	235	14	spray	spray	NN
cord-305263-fgwf6wy3	235	15	to	to	TO
cord-305263-fgwf6wy3	235	16	prevent	prevent	VB
cord-305263-fgwf6wy3	235	17	acute	acute	JJ
cord-305263-fgwf6wy3	235	18	viral	viral	JJ
cord-305263-fgwf6wy3	235	19	respiratory	respiratory	JJ
cord-305263-fgwf6wy3	235	20	infections	infection	NNS
cord-305263-fgwf6wy3	235	21	in	in	IN
cord-305263-fgwf6wy3	235	22	military	military	JJ
cord-305263-fgwf6wy3	235	23	recruits	recruit	NNS
cord-305263-fgwf6wy3	236	1	Peginterferon	peginterferon	JJ
cord-305263-fgwf6wy3	236	2	and	and	CC
cord-305263-fgwf6wy3	236	3	ribavirin	ribavirin	JJ
cord-305263-fgwf6wy3	236	4	treatment	treatment	NN
cord-305263-fgwf6wy3	236	5	for	for	IN
cord-305263-fgwf6wy3	236	6	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	236	7	C	C	NNP
cord-305263-fgwf6wy3	236	8	virus	virus	NN
cord-305263-fgwf6wy3	236	9	infection	infection	NN
cord-305263-fgwf6wy3	236	10	Secondary	secondary	JJ
cord-305263-fgwf6wy3	236	11	structure	structure	NN
cord-305263-fgwf6wy3	236	12	of	of	IN
cord-305263-fgwf6wy3	236	13	the	the	DT
cord-305263-fgwf6wy3	236	14	amino	amino	NN
cord-305263-fgwf6wy3	236	15	-	-	HYPH
cord-305263-fgwf6wy3	236	16	terminal	terminal	NN
cord-305263-fgwf6wy3	236	17	region	region	NN
cord-305263-fgwf6wy3	236	18	of	of	IN
cord-305263-fgwf6wy3	236	19	HCV	HCV	NNP
cord-305263-fgwf6wy3	236	20	NS3	NS3	NNP
cord-305263-fgwf6wy3	236	21	and	and	CC
cord-305263-fgwf6wy3	236	22	virological	virological	JJ
cord-305263-fgwf6wy3	236	23	response	response	NN
cord-305263-fgwf6wy3	236	24	to	to	IN
cord-305263-fgwf6wy3	236	25	pegylated	pegylated	JJ
cord-305263-fgwf6wy3	236	26	interferon	interferon	NN
cord-305263-fgwf6wy3	236	27	plus	plus	CC
cord-305263-fgwf6wy3	236	28	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	236	29	therapy	therapy	NN
cord-305263-fgwf6wy3	236	30	for	for	IN
cord-305263-fgwf6wy3	236	31	chronic	chronic	JJ
cord-305263-fgwf6wy3	236	32	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	236	33	C	c	NN
cord-305263-fgwf6wy3	236	34	Amino	amino	NN
cord-305263-fgwf6wy3	236	35	acid	acid	NN
cord-305263-fgwf6wy3	236	36	substitutions	substitution	NNS
cord-305263-fgwf6wy3	236	37	in	in	IN
cord-305263-fgwf6wy3	236	38	core	core	NN
cord-305263-fgwf6wy3	236	39	and	and	CC
cord-305263-fgwf6wy3	236	40	NS5A	NS5A	NNP
cord-305263-fgwf6wy3	236	41	regions	region	NNS
cord-305263-fgwf6wy3	236	42	of	of	IN
cord-305263-fgwf6wy3	236	43	the	the	DT
cord-305263-fgwf6wy3	236	44	HCV	HCV	NNP
cord-305263-fgwf6wy3	236	45	genome	genome	NN
cord-305263-fgwf6wy3	236	46	can	can	MD
cord-305263-fgwf6wy3	236	47	predict	predict	VB
cord-305263-fgwf6wy3	236	48	virological	virological	JJ
cord-305263-fgwf6wy3	236	49	decrease	decrease	NN
cord-305263-fgwf6wy3	236	50	with	with	IN
cord-305263-fgwf6wy3	236	51	pegylated	pegylated	JJ
cord-305263-fgwf6wy3	236	52	interferon	interferon	NN
cord-305263-fgwf6wy3	236	53	plus	plus	CC
cord-305263-fgwf6wy3	236	54	ribavirin	ribavirin	NNP
cord-305263-fgwf6wy3	236	55	therapy	therapy	NN
cord-305263-fgwf6wy3	236	56	Inhibition	Inhibition	NNP
cord-305263-fgwf6wy3	236	57	of	of	IN
cord-305263-fgwf6wy3	236	58	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	236	59	C	c	NN
cord-305263-fgwf6wy3	236	60	virus	virus	NN
cord-305263-fgwf6wy3	236	61	replication	replication	NN
cord-305263-fgwf6wy3	236	62	by	by	IN
cord-305263-fgwf6wy3	236	63	IFN	IFN	NNP
cord-305263-fgwf6wy3	236	64	-	-	HYPH
cord-305263-fgwf6wy3	236	65	mediated	mediate	VBN
cord-305263-fgwf6wy3	236	66	ISGylation	isgylation	NN
cord-305263-fgwf6wy3	236	67	of	of	IN
cord-305263-fgwf6wy3	236	68	HCV-	HCV-	NNP
cord-305263-fgwf6wy3	237	1	NS5A	NS5A	NNP
cord-305263-fgwf6wy3	238	1	Inhibition	inhibition	NN
cord-305263-fgwf6wy3	238	2	of	of	IN
cord-305263-fgwf6wy3	238	3	the	the	DT
cord-305263-fgwf6wy3	238	4	protein	protein	NN
cord-305263-fgwf6wy3	238	5	kinase	kinase	VBZ
cord-305263-fgwf6wy3	238	6	PKR	PKR	NNP
cord-305263-fgwf6wy3	238	7	by	by	IN
cord-305263-fgwf6wy3	238	8	the	the	DT
cord-305263-fgwf6wy3	238	9	internal	internal	JJ
cord-305263-fgwf6wy3	238	10	ribosome	ribosome	NN
cord-305263-fgwf6wy3	238	11	entry	entry	NN
cord-305263-fgwf6wy3	238	12	site	site	NN
cord-305263-fgwf6wy3	238	13	of	of	IN
cord-305263-fgwf6wy3	238	14	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	238	15	C	C	NNP
cord-305263-fgwf6wy3	238	16	virus	virus	NN
cord-305263-fgwf6wy3	238	17	genomic	genomic	JJ
cord-305263-fgwf6wy3	238	18	RNA	RNA	NNP
cord-305263-fgwf6wy3	238	19	Durability	Durability	NNP
cord-305263-fgwf6wy3	238	20	of	of	IN
cord-305263-fgwf6wy3	238	21	peginterferon	peginterferon	JJ
cord-305263-fgwf6wy3	238	22	alfa-2b	alfa-2b	NNP
cord-305263-fgwf6wy3	238	23	treatment	treatment	NN
cord-305263-fgwf6wy3	238	24	at	at	IN
cord-305263-fgwf6wy3	238	25	5	5	CD
cord-305263-fgwf6wy3	238	26	years	year	NNS
cord-305263-fgwf6wy3	238	27	in	in	IN
cord-305263-fgwf6wy3	238	28	patients	patient	NNS
cord-305263-fgwf6wy3	238	29	with	with	IN
cord-305263-fgwf6wy3	238	30	hepatitis	hepatitis	NNP
cord-305263-fgwf6wy3	238	31	B	B	NNP
cord-305263-fgwf6wy3	238	32	e	e	NN
cord-305263-fgwf6wy3	238	33	antigen	antigen	NN
cord-305263-fgwf6wy3	238	34	-	-	HYPH
cord-305263-fgwf6wy3	238	35	positive	positive	JJ
cord-305263-fgwf6wy3	238	36	chronic	chronic	NN
cord-305263-fgwf6wy3	238	37	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	238	38	B	b	NN
cord-305263-fgwf6wy3	238	39	Peginterferon	Peginterferon	NNP
cord-305263-fgwf6wy3	239	1	alfa-2a	alfa-2a	NNP
cord-305263-fgwf6wy3	239	2	,	,	,
cord-305263-fgwf6wy3	239	3	lamivudine	lamivudine	JJ
cord-305263-fgwf6wy3	239	4	,	,	,
cord-305263-fgwf6wy3	239	5	and	and	CC
cord-305263-fgwf6wy3	239	6	the	the	DT
cord-305263-fgwf6wy3	239	7	combination	combination	NN
cord-305263-fgwf6wy3	239	8	for	for	IN
cord-305263-fgwf6wy3	239	9	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	239	10	-	-	HYPH
cord-305263-fgwf6wy3	239	11	positive	positive	JJ
cord-305263-fgwf6wy3	239	12	chronic	chronic	NN
cord-305263-fgwf6wy3	239	13	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	239	14	B	B	NNP
cord-305263-fgwf6wy3	239	15	A	A	NNP
cord-305263-fgwf6wy3	239	16	randomized	randomized	JJ
cord-305263-fgwf6wy3	239	17	trial	trial	NN
cord-305263-fgwf6wy3	239	18	of	of	IN
cord-305263-fgwf6wy3	239	19	peginterferon	peginterferon	NNP
cord-305263-fgwf6wy3	240	1	alpha-2a	alpha-2a	VBG
cord-305263-fgwf6wy3	240	2	with	with	IN
cord-305263-fgwf6wy3	240	3	or	or	CC
cord-305263-fgwf6wy3	240	4	without	without	IN
cord-305263-fgwf6wy3	240	5	ribavirin	ribavirin	NN
cord-305263-fgwf6wy3	240	6	for	for	IN
cord-305263-fgwf6wy3	240	7	HBeAg	hbeag	CD
cord-305263-fgwf6wy3	240	8	-	-	HYPH
cord-305263-fgwf6wy3	240	9	negative	negative	JJ
cord-305263-fgwf6wy3	240	10	chronic	chronic	JJ
cord-305263-fgwf6wy3	240	11	hepatitis	hepatitis	NN
cord-305263-fgwf6wy3	240	12	B	b	NN
cord-305263-fgwf6wy3	240	13	Increasing	increase	VBG
cord-305263-fgwf6wy3	240	14	proportion	proportion	NN
cord-305263-fgwf6wy3	240	15	of	of	IN
cord-305263-fgwf6wy3	240	16	herpes	herpes	NN
cord-305263-fgwf6wy3	240	17	simplex	simplex	NNP
cord-305263-fgwf6wy3	240	18	virus	virus	NN
cord-305263-fgwf6wy3	240	19	type	type	NN
cord-305263-fgwf6wy3	240	20	I	-PRON-	PRP
cord-305263-fgwf6wy3	240	21	as	as	IN
cord-305263-fgwf6wy3	240	22	a	a	DT
cord-305263-fgwf6wy3	240	23	cause	cause	NN
cord-305263-fgwf6wy3	240	24	of	of	IN
cord-305263-fgwf6wy3	240	25	genital	genital	JJ
cord-305263-fgwf6wy3	240	26	herpes	herpes	NN
cord-305263-fgwf6wy3	240	27	infection	infection	NN
cord-305263-fgwf6wy3	240	28	in	in	IN
cord-305263-fgwf6wy3	240	29	college	college	NN
cord-305263-fgwf6wy3	240	30	students	student	NNS
cord-305263-fgwf6wy3	240	31	Herpes	Herpes	NNP
cord-305263-fgwf6wy3	240	32	simplex	simplex	NN
cord-305263-fgwf6wy3	240	33	virus	virus	NN
cord-305263-fgwf6wy3	240	34	encephalitis	encephalitis	RB
cord-305263-fgwf6wy3	240	35	:	:	:
cord-305263-fgwf6wy3	240	36	new	new	JJ
cord-305263-fgwf6wy3	240	37	infection	infection	NN
cord-305263-fgwf6wy3	240	38	or	or	CC
cord-305263-fgwf6wy3	240	39	reactivation	reactivation	NN
cord-305263-fgwf6wy3	240	40	?	?	.
cord-305263-fgwf6wy3	241	1	Replication	replication	NN
cord-305263-fgwf6wy3	241	2	of	of	IN
cord-305263-fgwf6wy3	241	3	herpes	herpes	NN
cord-305263-fgwf6wy3	241	4	simplex	simplex	NN
cord-305263-fgwf6wy3	241	5	virus	virus	NN
cord-305263-fgwf6wy3	241	6	1	1	CD
cord-305263-fgwf6wy3	241	7	depends	depend	VBZ
cord-305263-fgwf6wy3	241	8	on	on	IN
cord-305263-fgwf6wy3	241	9	the	the	DT
cord-305263-fgwf6wy3	241	10	g	g	NN
cord-305263-fgwf6wy3	241	11	1	1	CD
cord-305263-fgwf6wy3	241	12	34.5	34.5	CD
cord-305263-fgwf6wy3	241	13	functions	function	NNS
cord-305263-fgwf6wy3	241	14	that	that	WDT
cord-305263-fgwf6wy3	241	15	facilitate	facilitate	VBP
cord-305263-fgwf6wy3	241	16	virus	virus	NN
cord-305263-fgwf6wy3	241	17	response	response	NN
cord-305263-fgwf6wy3	241	18	to	to	IN
cord-305263-fgwf6wy3	241	19	interferon	interferon	NN
cord-305263-fgwf6wy3	241	20	and	and	CC
cord-305263-fgwf6wy3	241	21	egress	egress	NN
cord-305263-fgwf6wy3	241	22	in	in	IN
cord-305263-fgwf6wy3	241	23	the	the	DT
cord-305263-fgwf6wy3	241	24	different	different	JJ
cord-305263-fgwf6wy3	241	25	stages	stage	NNS
cord-305263-fgwf6wy3	241	26	of	of	IN
cord-305263-fgwf6wy3	241	27	productive	productive	JJ
cord-305263-fgwf6wy3	241	28	infection	infection	NN
cord-305263-fgwf6wy3	241	29	Inhibition	inhibition	NN
cord-305263-fgwf6wy3	241	30	of	of	IN
cord-305263-fgwf6wy3	241	31	cellular	cellular	JJ
cord-305263-fgwf6wy3	241	32	2	2	CD
cord-305263-fgwf6wy3	241	33	0	0	CD
cord-305263-fgwf6wy3	241	34	-5	-5	CD
cord-305263-fgwf6wy3	241	35	0	0	CD
cord-305263-fgwf6wy3	241	36	oligoadenylate	oligoadenylate	NN
cord-305263-fgwf6wy3	241	37	synthetase	synthetase	NN
cord-305263-fgwf6wy3	241	38	by	by	IN
cord-305263-fgwf6wy3	241	39	the	the	DT
cord-305263-fgwf6wy3	241	40	herpes	herpes	NNP
cord-305263-fgwf6wy3	241	41	simplex	simplex	NNP
cord-305263-fgwf6wy3	241	42	virus	virus	NN
cord-305263-fgwf6wy3	241	43	type	type	NN
cord-305263-fgwf6wy3	241	44	1	1	CD
cord-305263-fgwf6wy3	241	45	Us11	Us11	NNP
cord-305263-fgwf6wy3	241	46	protein	protein	NN
cord-305263-fgwf6wy3	242	1	Beta	beta	NN
cord-305263-fgwf6wy3	242	2	interferon	interferon	NN
cord-305263-fgwf6wy3	242	3	plus	plus	IN
cord-305263-fgwf6wy3	242	4	gamma	gamma	NN
cord-305263-fgwf6wy3	242	5	interferon	interferon	NN
cord-305263-fgwf6wy3	242	6	efficiently	efficiently	RB
cord-305263-fgwf6wy3	242	7	reduces	reduce	VBZ
cord-305263-fgwf6wy3	242	8	acyclovir	acyclovir	NN
cord-305263-fgwf6wy3	242	9	-	-	HYPH
cord-305263-fgwf6wy3	242	10	resistant	resistant	JJ
cord-305263-fgwf6wy3	242	11	herpes	herpes	NN
cord-305263-fgwf6wy3	242	12	simplex	simplex	NN
cord-305263-fgwf6wy3	242	13	virus	virus	NN
cord-305263-fgwf6wy3	242	14	infection	infection	NN
cord-305263-fgwf6wy3	242	15	in	in	IN
cord-305263-fgwf6wy3	242	16	mice	mouse	NNS
cord-305263-fgwf6wy3	242	17	in	in	IN
cord-305263-fgwf6wy3	242	18	a	a	DT
cord-305263-fgwf6wy3	242	19	T	T	NNP
cord-305263-fgwf6wy3	242	20	cell	cell	NN
cord-305263-fgwf6wy3	242	21	-	-	HYPH
cord-305263-fgwf6wy3	242	22	independent	independent	JJ
cord-305263-fgwf6wy3	242	23	manner	manner	NN
cord-305263-fgwf6wy3	242	24	Development	development	NN
cord-305263-fgwf6wy3	242	25	of	of	IN
cord-305263-fgwf6wy3	242	26	drug	drug	NN
cord-305263-fgwf6wy3	242	27	-	-	HYPH
cord-305263-fgwf6wy3	242	28	resistant	resistant	JJ
cord-305263-fgwf6wy3	242	29	herpes	herpes	NN
cord-305263-fgwf6wy3	242	30	simplex	simplex	NN
cord-305263-fgwf6wy3	242	31	virus	virus	NN
cord-305263-fgwf6wy3	242	32	infection	infection	NN
cord-305263-fgwf6wy3	242	33	after	after	IN
cord-305263-fgwf6wy3	242	34	haploidentical	haploidentical	JJ
cord-305263-fgwf6wy3	242	35	hematopoietic	hematopoietic	JJ
cord-305263-fgwf6wy3	242	36	progenitor	progenitor	NN
cord-305263-fgwf6wy3	242	37	cell	cell	NN
cord-305263-fgwf6wy3	242	38	transplantation	transplantation	NN
cord-305263-fgwf6wy3	242	39	Herpes	Herpes	NNP
cord-305263-fgwf6wy3	242	40	simplex	simplex	NN
cord-305263-fgwf6wy3	242	41	virus	virus	NN
cord-305263-fgwf6wy3	242	42	resistance	resistance	NN
cord-305263-fgwf6wy3	242	43	to	to	IN
cord-305263-fgwf6wy3	242	44	acyclovir	acyclovir	NNP
cord-305263-fgwf6wy3	242	45	and	and	CC
cord-305263-fgwf6wy3	242	46	penciclovir	penciclovir	NNP
cord-305263-fgwf6wy3	242	47	after	after	IN
cord-305263-fgwf6wy3	242	48	two	two	CD
cord-305263-fgwf6wy3	242	49	decades	decade	NNS
cord-305263-fgwf6wy3	242	50	of	of	IN
cord-305263-fgwf6wy3	242	51	antiviral	antiviral	JJ
cord-305263-fgwf6wy3	242	52	therapy	therapy	NN
cord-305263-fgwf6wy3	242	53	Use	Use	NNP
cord-305263-fgwf6wy3	242	54	of	of	IN
cord-305263-fgwf6wy3	242	55	interferon	interferon	NN
cord-305263-fgwf6wy3	242	56	-	-	:
cord-305263-fgwf6wy3	242	57	a	a	NN
cord-305263-fgwf6wy3	242	58	in	in	IN
cord-305263-fgwf6wy3	242	59	patients	patient	NNS
cord-305263-fgwf6wy3	242	60	with	with	IN
cord-305263-fgwf6wy3	242	61	West	West	NNP
cord-305263-fgwf6wy3	242	62	Nile	Nile	NNP
cord-305263-fgwf6wy3	242	63	encephalitis	encephalitis	RB
cord-305263-fgwf6wy3	242	64	:	:	:
cord-305263-fgwf6wy3	243	1	report	report	NN
cord-305263-fgwf6wy3	243	2	of	of	IN
cord-305263-fgwf6wy3	243	3	2	2	CD
cord-305263-fgwf6wy3	243	4	cases	case	NNS
cord-305263-fgwf6wy3	243	5	Treatment	treatment	NN
cord-305263-fgwf6wy3	243	6	of	of	IN
cord-305263-fgwf6wy3	243	7	yellow	yellow	JJ
cord-305263-fgwf6wy3	243	8	fever	fever	NN
cord-305263-fgwf6wy3	243	9	virus	virus	NN
cord-305263-fgwf6wy3	243	10	with	with	IN
cord-305263-fgwf6wy3	243	11	an	an	DT
cord-305263-fgwf6wy3	243	12	adenovirus	adenovirus	NN
cord-305263-fgwf6wy3	243	13	-	-	HYPH
cord-305263-fgwf6wy3	243	14	vectored	vectore	VBN
cord-305263-fgwf6wy3	243	15	interferon	interferon	NN
cord-305263-fgwf6wy3	243	16	,	,	,
cord-305263-fgwf6wy3	243	17	DEF201	DEF201	NNP
cord-305263-fgwf6wy3	243	18	,	,	,
cord-305263-fgwf6wy3	243	19	in	in	IN
cord-305263-fgwf6wy3	243	20	a	a	DT
cord-305263-fgwf6wy3	243	21	hamster	hamster	NN
cord-305263-fgwf6wy3	243	22	model	model	NN
cord-305263-fgwf6wy3	243	23	Evaulation	Evaulation	NNP
cord-305263-fgwf6wy3	243	24	of	of	IN
cord-305263-fgwf6wy3	243	25	immune	immune	JJ
cord-305263-fgwf6wy3	243	26	globulin	globulin	NN
cord-305263-fgwf6wy3	243	27	and	and	CC
cord-305263-fgwf6wy3	243	28	recombinant	recombinant	JJ
cord-305263-fgwf6wy3	243	29	interferon	interferon	NN
cord-305263-fgwf6wy3	243	30	-	-	HYPH
cord-305263-fgwf6wy3	243	31	a2b	a2b	NNP
cord-305263-fgwf6wy3	243	32	for	for	IN
cord-305263-fgwf6wy3	243	33	treatment	treatment	NN
cord-305263-fgwf6wy3	243	34	of	of	IN
cord-305263-fgwf6wy3	243	35	experimental	experimental	JJ
cord-305263-fgwf6wy3	243	36	Ebola	Ebola	NNP
cord-305263-fgwf6wy3	243	37	virus	virus	NN
cord-305263-fgwf6wy3	243	38	infections	infection	NNS
cord-305263-fgwf6wy3	243	39	Evidence	evidence	NN
cord-305263-fgwf6wy3	243	40	for	for	IN
cord-305263-fgwf6wy3	243	41	glycosphingolipid	glycosphingolipid	NN
cord-305263-fgwf6wy3	243	42	modification	modification	NN
cord-305263-fgwf6wy3	243	43	of	of	IN
cord-305263-fgwf6wy3	243	44	the	the	DT
cord-305263-fgwf6wy3	243	45	type	type	NN
cord-305263-fgwf6wy3	243	46	1	1	CD
cord-305263-fgwf6wy3	243	47	IFN	IFN	NNP
cord-305263-fgwf6wy3	243	48	receptor	receptor	NN
cord-305263-fgwf6wy3	243	49	A	a	DT
cord-305263-fgwf6wy3	243	50	structural	structural	JJ
cord-305263-fgwf6wy3	243	51	basis	basis	NN
cord-305263-fgwf6wy3	243	52	for	for	IN
cord-305263-fgwf6wy3	243	53	interferon	interferon	NN
cord-305263-fgwf6wy3	243	54	-	-	HYPH
cord-305263-fgwf6wy3	243	55	a	a	DT
cord-305263-fgwf6wy3	243	56	-	-	HYPH
cord-305263-fgwf6wy3	243	57	receptor	receptor	NN
cord-305263-fgwf6wy3	243	58	interactions	interaction	NNS
cord-305263-fgwf6wy3	243	59	TSC2	TSC2	NNP
cord-305263-fgwf6wy3	243	60	is	be	VBZ
cord-305263-fgwf6wy3	243	61	phosphorylated	phosphorylate	VBN
cord-305263-fgwf6wy3	243	62	and	and	CC
cord-305263-fgwf6wy3	243	63	inhibited	inhibit	VBN
cord-305263-fgwf6wy3	243	64	by	by	IN
cord-305263-fgwf6wy3	243	65	Akt	Akt	NNP
cord-305263-fgwf6wy3	243	66	and	and	CC
cord-305263-fgwf6wy3	243	67	suppresses	suppress	VBZ
cord-305263-fgwf6wy3	244	1	mTOR	mTOR	NNP
cord-305263-fgwf6wy3	244	2	signalling	signal	VBG
cord-305263-fgwf6wy3	244	3	Promyelocytic	Promyelocytic	NNP
cord-305263-fgwf6wy3	244	4	leukemia	leukemia	NN
cord-305263-fgwf6wy3	244	5	zinc	zinc	NN
cord-305263-fgwf6wy3	244	6	finger	finger	NN
cord-305263-fgwf6wy3	244	7	protein	protein	NN
cord-305263-fgwf6wy3	244	8	regulates	regulate	VBZ
cord-305263-fgwf6wy3	244	9	interferon	interferon	NN
cord-305263-fgwf6wy3	244	10	-	-	HYPH
cord-305263-fgwf6wy3	244	11	mediated	mediate	VBN
cord-305263-fgwf6wy3	244	12	innate	innate	JJ
cord-305263-fgwf6wy3	244	13	immunity	immunity	NN
cord-305263-fgwf6wy3	245	1	The	the	DT
cord-305263-fgwf6wy3	246	1	ISG56	ISG56	NNP
cord-305263-fgwf6wy3	246	2	/	/	SYM
cord-305263-fgwf6wy3	246	3	IFIT1	IFIT1	NNP
cord-305263-fgwf6wy3	246	4	gene	gene	NN
cord-305263-fgwf6wy3	246	5	family	family	NN
cord-305263-fgwf6wy3	247	1	Distinct	distinct	JJ
cord-305263-fgwf6wy3	247	2	patterns	pattern	NNS
cord-305263-fgwf6wy3	247	3	of	of	IN
cord-305263-fgwf6wy3	247	4	IFITM	ifitm	NN
cord-305263-fgwf6wy3	247	5	-	-	HYPH
cord-305263-fgwf6wy3	247	6	mediated	mediate	VBN
cord-305263-fgwf6wy3	247	7	restriction	restriction	NN
cord-305263-fgwf6wy3	247	8	of	of	IN
cord-305263-fgwf6wy3	247	9	filoviruses	filovirus	NNS
cord-305263-fgwf6wy3	247	10	,	,	,
cord-305263-fgwf6wy3	247	11	SARS	SARS	NNP
cord-305263-fgwf6wy3	247	12	coronavirus	coronavirus	NN
cord-305263-fgwf6wy3	247	13	,	,	,
cord-305263-fgwf6wy3	247	14	and	and	CC
cord-305263-fgwf6wy3	247	15	influenza	influenza	NN
cord-305263-fgwf6wy3	247	16	A	a	DT
cord-305263-fgwf6wy3	247	17	virus	virus	NN
cord-305263-fgwf6wy3	247	18	Association	Association	NNP
cord-305263-fgwf6wy3	247	19	of	of	IN
cord-305263-fgwf6wy3	247	20	TRIM22	TRIM22	NNP
cord-305263-fgwf6wy3	247	21	with	with	IN
cord-305263-fgwf6wy3	247	22	the	the	DT
cord-305263-fgwf6wy3	247	23	type	type	NN
cord-305263-fgwf6wy3	247	24	1	1	CD
cord-305263-fgwf6wy3	247	25	interferon	interferon	NN
cord-305263-fgwf6wy3	247	26	response	response	NN
cord-305263-fgwf6wy3	247	27	and	and	CC
cord-305263-fgwf6wy3	247	28	viral	viral	JJ
cord-305263-fgwf6wy3	247	29	control	control	NN
cord-305263-fgwf6wy3	247	30	during	during	IN
cord-305263-fgwf6wy3	247	31	primary	primary	JJ
cord-305263-fgwf6wy3	247	32	HIV-1	HIV-1	NNP
cord-305263-fgwf6wy3	247	33	infection	infection	NN
cord-305263-fgwf6wy3	247	34	Interferon	interferon	NN
cord-305263-fgwf6wy3	247	35	-	-	HYPH
cord-305263-fgwf6wy3	247	36	inducible	inducible	JJ
cord-305263-fgwf6wy3	247	37	Stat2	stat2	NN
cord-305263-fgwf6wy3	247	38	activation	activation	NN
cord-305263-fgwf6wy3	247	39	of	of	IN
cord-305263-fgwf6wy3	247	40	JUND	JUND	NNP
cord-305263-fgwf6wy3	247	41	and	and	CC
cord-305263-fgwf6wy3	247	42	CLDN4	CLDN4	NNP
cord-305263-fgwf6wy3	247	43	:	:	:
cord-305263-fgwf6wy3	247	44	mediators	mediator	NNS
cord-305263-fgwf6wy3	247	45	of	of	IN
cord-305263-fgwf6wy3	247	46	IFN	IFN	NNP
cord-305263-fgwf6wy3	247	47	responses	response	VBZ
cord-305263-fgwf6wy3	247	48	Direct	direct	JJ
cord-305263-fgwf6wy3	247	49	effects	effect	NNS
cord-305263-fgwf6wy3	247	50	of	of	IN
cord-305263-fgwf6wy3	247	51	type	type	NN
cord-305263-fgwf6wy3	248	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	248	2	interferons	interferon	NNS
cord-305263-fgwf6wy3	248	3	on	on	IN
cord-305263-fgwf6wy3	248	4	cells	cell	NNS
cord-305263-fgwf6wy3	248	5	of	of	IN
cord-305263-fgwf6wy3	248	6	the	the	DT
cord-305263-fgwf6wy3	248	7	immune	immune	JJ
cord-305263-fgwf6wy3	248	8	system	system	NN
cord-305263-fgwf6wy3	248	9	Virus	virus	NN
cord-305263-fgwf6wy3	248	10	-	-	HYPH
cord-305263-fgwf6wy3	248	11	induced	induce	VBN
cord-305263-fgwf6wy3	248	12	type	type	NN
cord-305263-fgwf6wy3	249	1	I	-PRON-	PRP
cord-305263-fgwf6wy3	249	2	IFN	IFN	NNP
cord-305263-fgwf6wy3	249	3	stimulates	stimulate	VBZ
cord-305263-fgwf6wy3	249	4	generation	generation	NN
cord-305263-fgwf6wy3	249	5	of	of	IN
cord-305263-fgwf6wy3	249	6	immunoproteasomes	immunoproteasome	NNS
cord-305263-fgwf6wy3	249	7	at	at	IN
cord-305263-fgwf6wy3	249	8	the	the	DT
cord-305263-fgwf6wy3	249	9	site	site	NN
cord-305263-fgwf6wy3	249	10	of	of	IN
cord-305263-fgwf6wy3	249	11	infection	infection	NN
cord-305263-fgwf6wy3	249	12	IFN	IFN	NNP
cord-305263-fgwf6wy3	249	13	-	-	:
cord-305263-fgwf6wy3	249	14	a	a	DT
cord-305263-fgwf6wy3	249	15	secretion	secretion	NN
cord-305263-fgwf6wy3	249	16	by	by	IN
cord-305263-fgwf6wy3	249	17	type	type	NN
cord-305263-fgwf6wy3	249	18	2	2	CD
cord-305263-fgwf6wy3	249	19	predendritic	predendritic	NN
cord-305263-fgwf6wy3	249	20	cells	cell	NNS
cord-305263-fgwf6wy3	249	21	upregulates	upregulate	VBZ
cord-305263-fgwf6wy3	249	22	MHC	MHC	NNP
cord-305263-fgwf6wy3	249	23	Class	Class	NNP
cord-305263-fgwf6wy3	249	24	I	-PRON-	PRP
cord-305263-fgwf6wy3	249	25	in	in	IN
cord-305263-fgwf6wy3	249	26	the	the	DT
cord-305263-fgwf6wy3	249	27	HIV-1-infected	hiv-1-infecte	VBN
cord-305263-fgwf6wy3	249	28	thymus	thymus	NN
cord-305263-fgwf6wy3	249	29	Involvement	Involvement	NNP
cord-305263-fgwf6wy3	249	30	of	of	IN
cord-305263-fgwf6wy3	249	31	Fas	Fas	NNP
cord-305263-fgwf6wy3	249	32	-	-	HYPH
cord-305263-fgwf6wy3	249	33	mediated	mediate	VBN
cord-305263-fgwf6wy3	249	34	apoptosis	apoptosis	NN
cord-305263-fgwf6wy3	249	35	in	in	IN
cord-305263-fgwf6wy3	249	36	the	the	DT
cord-305263-fgwf6wy3	249	37	inhibitory	inhibitory	JJ
cord-305263-fgwf6wy3	249	38	effects	effect	NNS
cord-305263-fgwf6wy3	249	39	of	of	IN
cord-305263-fgwf6wy3	249	40	interferon	interferon	NN
cord-305263-fgwf6wy3	249	41	-	-	HYPH
cord-305263-fgwf6wy3	249	42	alpha	alpha	NN
cord-305263-fgwf6wy3	249	43	in	in	IN
cord-305263-fgwf6wy3	249	44	chronic	chronic	JJ
cord-305263-fgwf6wy3	249	45	myelogenous	myelogenous	NN
cord-305263-fgwf6wy3	249	46	leukemia	leukemia	NN
cord-305263-fgwf6wy3	249	47	Dynamic	dynamic	JJ
cord-305263-fgwf6wy3	249	48	accumulation	accumulation	NN
cord-305263-fgwf6wy3	249	49	of	of	IN
cord-305263-fgwf6wy3	249	50	plasmacytoid	plasmacytoid	NNP
cord-305263-fgwf6wy3	249	51	dendritic	dendritic	JJ
cord-305263-fgwf6wy3	249	52	cells	cell	NNS
cord-305263-fgwf6wy3	249	53	in	in	IN
cord-305263-fgwf6wy3	249	54	lymph	lymph	NN
cord-305263-fgwf6wy3	249	55	nodes	node	NNS
cord-305263-fgwf6wy3	249	56	is	be	VBZ
cord-305263-fgwf6wy3	249	57	regulated	regulate	VBN
cord-305263-fgwf6wy3	249	58	by	by	IN
cord-305263-fgwf6wy3	249	59	interferon	interferon	NN
cord-305263-fgwf6wy3	249	60	-	-	HYPH
cord-305263-fgwf6wy3	249	61	b	b	NN
cord-305263-fgwf6wy3	249	62	Effect	effect	NN
cord-305263-fgwf6wy3	249	63	of	of	IN
cord-305263-fgwf6wy3	249	64	interferon	interferon	NN
cord-305263-fgwf6wy3	249	65	-	-	:
cord-305263-fgwf6wy3	249	66	alpha(2a	alpha(2a	NNP
cord-305263-fgwf6wy3	249	67	)	)	-RRB-
cord-305263-fgwf6wy3	249	68	on	on	IN
cord-305263-fgwf6wy3	249	69	neutrophil	neutrophil	NN
cord-305263-fgwf6wy3	249	70	adhesion	adhesion	NN
cord-305263-fgwf6wy3	249	71	and	and	CC
cord-305263-fgwf6wy3	249	72	phagocytosis	phagocytosis	NN
cord-305263-fgwf6wy3	249	73	in	in	IN
cord-305263-fgwf6wy3	249	74	chronic	chronic	JJ
cord-305263-fgwf6wy3	249	75	myeloid	myeloid	NN
cord-305263-fgwf6wy3	249	76	leukemia	leukemia	NN
cord-305263-fgwf6wy3	249	77	and	and	CC
cord-305263-fgwf6wy3	249	78	Behçet	Behçet	NNP
cord-305263-fgwf6wy3	249	79	's	's	POS
cord-305263-fgwf6wy3	249	80	disease	disease	NN
cord-305263-fgwf6wy3	250	1	IFNalpha	IFNalpha	NNP
cord-305263-fgwf6wy3	250	2	regulates	regulate	VBZ
cord-305263-fgwf6wy3	250	3	NK	NK	NNP
cord-305263-fgwf6wy3	250	4	cell	cell	NN
cord-305263-fgwf6wy3	250	5	cytotoxicity	cytotoxicity	NN
cord-305263-fgwf6wy3	250	6	through	through	IN
cord-305263-fgwf6wy3	250	7	STAT1	STAT1	``
cord-305263-fgwf6wy3	250	8	pathway	pathway	NN
cord-305263-fgwf6wy3	250	9	Induction	Induction	NNP
cord-305263-fgwf6wy3	250	10	of	of	IN
cord-305263-fgwf6wy3	250	11	interferon	interferon	NN
cord-305263-fgwf6wy3	250	12	-	-	HYPH
cord-305263-fgwf6wy3	250	13	gamma	gamma	NN
cord-305263-fgwf6wy3	250	14	from	from	IN
cord-305263-fgwf6wy3	250	15	natural	natural	JJ
cord-305263-fgwf6wy3	250	16	killer	killer	NN
cord-305263-fgwf6wy3	250	17	cells	cell	NNS
cord-305263-fgwf6wy3	250	18	by	by	IN
cord-305263-fgwf6wy3	250	19	immunostimulatory	immunostimulatory	NNP
cord-305263-fgwf6wy3	250	20	CpG	CpG	NNP
cord-305263-fgwf6wy3	250	21	DNA	DNA	NNP
cord-305263-fgwf6wy3	250	22	is	be	VBZ
cord-305263-fgwf6wy3	250	23	mediated	mediate	VBN
cord-305263-fgwf6wy3	250	24	through	through	IN
cord-305263-fgwf6wy3	250	25	plasmacytoid	plasmacytoid	JJ
cord-305263-fgwf6wy3	250	26	-	-	HYPH
cord-305263-fgwf6wy3	250	27	dendritic	dendritic	JJ
cord-305263-fgwf6wy3	250	28	-	-	HYPH
cord-305263-fgwf6wy3	250	29	cell	cell	NN
cord-305263-fgwf6wy3	250	30	-	-	HYPH
cord-305263-fgwf6wy3	250	31	produced	produce	VBN
cord-305263-fgwf6wy3	250	32	interferon	interferon	NN
cord-305263-fgwf6wy3	250	33	-	-	HYPH
cord-305263-fgwf6wy3	250	34	alpha	alpha	NN
cord-305263-fgwf6wy3	250	35	and	and	CC
cord-305263-fgwf6wy3	250	36	tumour	tumour	NN
cord-305263-fgwf6wy3	250	37	necrosis	necrosis	NN
cord-305263-fgwf6wy3	250	38	factor	factor	NN
cord-305263-fgwf6wy3	250	39	-	-	HYPH
cord-305263-fgwf6wy3	250	40	alpha	alpha	NN
cord-305263-fgwf6wy3	250	41	Inhibition	inhibition	NN
cord-305263-fgwf6wy3	250	42	of	of	IN
cord-305263-fgwf6wy3	250	43	the	the	DT
cord-305263-fgwf6wy3	250	44	interferon	interferon	NN
cord-305263-fgwf6wy3	250	45	-	-	HYPH
cord-305263-fgwf6wy3	250	46	inducible	inducible	JJ
cord-305263-fgwf6wy3	250	47	protein	protein	NN
cord-305263-fgwf6wy3	250	48	kinase	kinase	VBZ
cord-305263-fgwf6wy3	250	49	PKR	PKR	NNP
cord-305263-fgwf6wy3	250	50	by	by	IN
cord-305263-fgwf6wy3	250	51	HCV	HCV	NNP
cord-305263-fgwf6wy3	250	52	E2	E2	NNP
cord-305263-fgwf6wy3	250	53	protein	protein	NN