id sid tid token lemma pos cord-298525-hhcfrjrn 1 1 key key NNP cord-298525-hhcfrjrn 1 2 : : : cord-298525-hhcfrjrn 1 3 cord-298525-hhcfrjrn cord-298525-hhcfrjrn NNP cord-298525-hhcfrjrn 2 1 authors author NNS cord-298525-hhcfrjrn 2 2 : : : cord-298525-hhcfrjrn 2 3 Hall Hall NNP cord-298525-hhcfrjrn 2 4 , , , cord-298525-hhcfrjrn 2 5 Charlotte Charlotte NNP cord-298525-hhcfrjrn 2 6 A. a. NN cord-298525-hhcfrjrn 2 7 ; ; : cord-298525-hhcfrjrn 2 8 Chilcott Chilcott NNP cord-298525-hhcfrjrn 2 9 , , , cord-298525-hhcfrjrn 2 10 Robert Robert NNP cord-298525-hhcfrjrn 2 11 P. P. NNP cord-298525-hhcfrjrn 2 12 title title NN cord-298525-hhcfrjrn 2 13 : : : cord-298525-hhcfrjrn 2 14 Eyeing eye VBG cord-298525-hhcfrjrn 2 15 up up RP cord-298525-hhcfrjrn 2 16 the the DT cord-298525-hhcfrjrn 2 17 Future Future NNP cord-298525-hhcfrjrn 2 18 of of IN cord-298525-hhcfrjrn 2 19 the the DT cord-298525-hhcfrjrn 2 20 Pupillary Pupillary NNP cord-298525-hhcfrjrn 2 21 Light Light NNP cord-298525-hhcfrjrn 2 22 Reflex Reflex NNP cord-298525-hhcfrjrn 2 23 in in IN cord-298525-hhcfrjrn 2 24 Neurodiagnostics Neurodiagnostics NNP cord-298525-hhcfrjrn 2 25 date date NN cord-298525-hhcfrjrn 2 26 : : : cord-298525-hhcfrjrn 2 27 2018 2018 CD cord-298525-hhcfrjrn 2 28 - - HYPH cord-298525-hhcfrjrn 2 29 03 03 CD cord-298525-hhcfrjrn 2 30 - - SYM cord-298525-hhcfrjrn 2 31 13 13 CD cord-298525-hhcfrjrn 2 32 journal journal NN cord-298525-hhcfrjrn 2 33 : : : cord-298525-hhcfrjrn 2 34 Diagnostics Diagnostics NNP cord-298525-hhcfrjrn 2 35 ( ( -LRB- cord-298525-hhcfrjrn 2 36 Basel Basel NNP cord-298525-hhcfrjrn 2 37 ) ) -RRB- cord-298525-hhcfrjrn 2 38 DOI DOI NNP cord-298525-hhcfrjrn 2 39 : : : cord-298525-hhcfrjrn 3 1 10.3390 10.3390 CD cord-298525-hhcfrjrn 3 2 / / SYM cord-298525-hhcfrjrn 3 3 diagnostics8010019 diagnostics8010019 NNP cord-298525-hhcfrjrn 3 4 sha sha NNP cord-298525-hhcfrjrn 3 5 : : : cord-298525-hhcfrjrn 4 1 88836be43482650dfdb4fc0cc47ca6e2d6afd759 88836be43482650dfdb4fc0cc47ca6e2d6afd759 CD cord-298525-hhcfrjrn 4 2 doc_id doc_id CD cord-298525-hhcfrjrn 4 3 : : : cord-298525-hhcfrjrn 4 4 298525 298525 CD cord-298525-hhcfrjrn 4 5 cord_uid cord_uid NNS cord-298525-hhcfrjrn 4 6 : : : cord-298525-hhcfrjrn 5 1 hhcfrjrn hhcfrjrn NNP cord-298525-hhcfrjrn 6 1 The the DT cord-298525-hhcfrjrn 6 2 pupillary pupillary JJ cord-298525-hhcfrjrn 6 3 light light JJ cord-298525-hhcfrjrn 6 4 reflex reflex NN cord-298525-hhcfrjrn 6 5 ( ( -LRB- cord-298525-hhcfrjrn 6 6 PLR PLR NNP cord-298525-hhcfrjrn 6 7 ) ) -RRB- cord-298525-hhcfrjrn 6 8 describes describe VBZ cord-298525-hhcfrjrn 6 9 the the DT cord-298525-hhcfrjrn 6 10 constriction constriction NN cord-298525-hhcfrjrn 6 11 and and CC cord-298525-hhcfrjrn 6 12 subsequent subsequent JJ cord-298525-hhcfrjrn 6 13 dilation dilation NN cord-298525-hhcfrjrn 6 14 of of IN cord-298525-hhcfrjrn 6 15 the the DT cord-298525-hhcfrjrn 6 16 pupil pupil NN cord-298525-hhcfrjrn 6 17 in in IN cord-298525-hhcfrjrn 6 18 response response NN cord-298525-hhcfrjrn 6 19 to to TO cord-298525-hhcfrjrn 6 20 light light NN cord-298525-hhcfrjrn 6 21 as as IN cord-298525-hhcfrjrn 6 22 a a DT cord-298525-hhcfrjrn 6 23 result result NN cord-298525-hhcfrjrn 6 24 of of IN cord-298525-hhcfrjrn 6 25 the the DT cord-298525-hhcfrjrn 6 26 antagonistic antagonistic JJ cord-298525-hhcfrjrn 6 27 actions action NNS cord-298525-hhcfrjrn 6 28 of of IN cord-298525-hhcfrjrn 6 29 the the DT cord-298525-hhcfrjrn 6 30 iris iris NNP cord-298525-hhcfrjrn 6 31 sphincter sphincter NN cord-298525-hhcfrjrn 6 32 and and CC cord-298525-hhcfrjrn 6 33 dilator dilator NN cord-298525-hhcfrjrn 6 34 muscles muscle NNS cord-298525-hhcfrjrn 6 35 . . . cord-298525-hhcfrjrn 7 1 Since since IN cord-298525-hhcfrjrn 7 2 these these DT cord-298525-hhcfrjrn 7 3 muscles muscle NNS cord-298525-hhcfrjrn 7 4 are be VBP cord-298525-hhcfrjrn 7 5 innervated innervate VBN cord-298525-hhcfrjrn 7 6 by by IN cord-298525-hhcfrjrn 7 7 the the DT cord-298525-hhcfrjrn 7 8 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 7 9 and and CC cord-298525-hhcfrjrn 7 10 sympathetic sympathetic JJ cord-298525-hhcfrjrn 7 11 nervous nervous JJ cord-298525-hhcfrjrn 7 12 systems system NNS cord-298525-hhcfrjrn 7 13 , , , cord-298525-hhcfrjrn 7 14 respectively respectively RB cord-298525-hhcfrjrn 7 15 , , , cord-298525-hhcfrjrn 7 16 different different JJ cord-298525-hhcfrjrn 7 17 parameters parameter NNS cord-298525-hhcfrjrn 7 18 of of IN cord-298525-hhcfrjrn 7 19 the the DT cord-298525-hhcfrjrn 7 20 PLR plr NN cord-298525-hhcfrjrn 7 21 can can MD cord-298525-hhcfrjrn 7 22 be be VB cord-298525-hhcfrjrn 7 23 used use VBN cord-298525-hhcfrjrn 7 24 as as IN cord-298525-hhcfrjrn 7 25 indicators indicator NNS cord-298525-hhcfrjrn 7 26 for for IN cord-298525-hhcfrjrn 7 27 either either CC cord-298525-hhcfrjrn 7 28 sympathetic sympathetic JJ cord-298525-hhcfrjrn 7 29 or or CC cord-298525-hhcfrjrn 7 30 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 7 31 modulation modulation NN cord-298525-hhcfrjrn 7 32 . . . cord-298525-hhcfrjrn 8 1 Thus thus RB cord-298525-hhcfrjrn 8 2 , , , cord-298525-hhcfrjrn 8 3 the the DT cord-298525-hhcfrjrn 8 4 PLR plr NN cord-298525-hhcfrjrn 8 5 provides provide VBZ cord-298525-hhcfrjrn 8 6 an an DT cord-298525-hhcfrjrn 8 7 important important JJ cord-298525-hhcfrjrn 8 8 metric metric NN cord-298525-hhcfrjrn 8 9 of of IN cord-298525-hhcfrjrn 8 10 autonomic autonomic JJ cord-298525-hhcfrjrn 8 11 nervous nervous JJ cord-298525-hhcfrjrn 8 12 system system NN cord-298525-hhcfrjrn 8 13 function function NN cord-298525-hhcfrjrn 8 14 that that WDT cord-298525-hhcfrjrn 8 15 has have VBZ cord-298525-hhcfrjrn 8 16 been be VBN cord-298525-hhcfrjrn 8 17 exploited exploit VBN cord-298525-hhcfrjrn 8 18 for for IN cord-298525-hhcfrjrn 8 19 a a DT cord-298525-hhcfrjrn 8 20 wide wide JJ cord-298525-hhcfrjrn 8 21 range range NN cord-298525-hhcfrjrn 8 22 of of IN cord-298525-hhcfrjrn 8 23 clinical clinical JJ cord-298525-hhcfrjrn 8 24 applications application NNS cord-298525-hhcfrjrn 8 25 . . . cord-298525-hhcfrjrn 9 1 Measurement measurement NN cord-298525-hhcfrjrn 9 2 of of IN cord-298525-hhcfrjrn 9 3 the the DT cord-298525-hhcfrjrn 9 4 PLR plr NN cord-298525-hhcfrjrn 9 5 using use VBG cord-298525-hhcfrjrn 9 6 dynamic dynamic JJ cord-298525-hhcfrjrn 9 7 pupillometry pupillometry NN cord-298525-hhcfrjrn 9 8 is be VBZ cord-298525-hhcfrjrn 9 9 now now RB cord-298525-hhcfrjrn 9 10 an an DT cord-298525-hhcfrjrn 9 11 established establish VBN cord-298525-hhcfrjrn 9 12 quantitative quantitative JJ cord-298525-hhcfrjrn 9 13 , , , cord-298525-hhcfrjrn 9 14 non non JJ cord-298525-hhcfrjrn 9 15 - - JJ cord-298525-hhcfrjrn 9 16 invasive invasive JJ cord-298525-hhcfrjrn 9 17 tool tool NN cord-298525-hhcfrjrn 9 18 in in IN cord-298525-hhcfrjrn 9 19 assessment assessment NN cord-298525-hhcfrjrn 9 20 of of IN cord-298525-hhcfrjrn 9 21 traumatic traumatic JJ cord-298525-hhcfrjrn 9 22 head head NN cord-298525-hhcfrjrn 9 23 injuries injury NNS cord-298525-hhcfrjrn 9 24 . . . cord-298525-hhcfrjrn 10 1 This this DT cord-298525-hhcfrjrn 10 2 review review NN cord-298525-hhcfrjrn 10 3 examines examine VBZ cord-298525-hhcfrjrn 10 4 the the DT cord-298525-hhcfrjrn 10 5 more more RBR cord-298525-hhcfrjrn 10 6 recent recent JJ cord-298525-hhcfrjrn 10 7 application application NN cord-298525-hhcfrjrn 10 8 of of IN cord-298525-hhcfrjrn 10 9 dynamic dynamic JJ cord-298525-hhcfrjrn 10 10 pupillometry pupillometry NN cord-298525-hhcfrjrn 10 11 as as IN cord-298525-hhcfrjrn 10 12 a a DT cord-298525-hhcfrjrn 10 13 diagnostic diagnostic JJ cord-298525-hhcfrjrn 10 14 tool tool NN cord-298525-hhcfrjrn 10 15 for for IN cord-298525-hhcfrjrn 10 16 a a DT cord-298525-hhcfrjrn 10 17 wide wide JJ cord-298525-hhcfrjrn 10 18 range range NN cord-298525-hhcfrjrn 10 19 of of IN cord-298525-hhcfrjrn 10 20 clinical clinical JJ cord-298525-hhcfrjrn 10 21 conditions condition NNS cord-298525-hhcfrjrn 10 22 , , , cord-298525-hhcfrjrn 10 23 varying vary VBG cord-298525-hhcfrjrn 10 24 from from IN cord-298525-hhcfrjrn 10 25 neurodegenerative neurodegenerative JJ cord-298525-hhcfrjrn 10 26 disease disease NN cord-298525-hhcfrjrn 10 27 to to IN cord-298525-hhcfrjrn 10 28 exposure exposure NN cord-298525-hhcfrjrn 10 29 to to IN cord-298525-hhcfrjrn 10 30 toxic toxic JJ cord-298525-hhcfrjrn 10 31 chemicals chemical NNS cord-298525-hhcfrjrn 10 32 , , , cord-298525-hhcfrjrn 10 33 as as RB cord-298525-hhcfrjrn 10 34 well well RB cord-298525-hhcfrjrn 10 35 as as IN cord-298525-hhcfrjrn 10 36 its -PRON- PRP$ cord-298525-hhcfrjrn 10 37 potential potential NN cord-298525-hhcfrjrn 10 38 in in IN cord-298525-hhcfrjrn 10 39 the the DT cord-298525-hhcfrjrn 10 40 non non JJ cord-298525-hhcfrjrn 10 41 - - JJ cord-298525-hhcfrjrn 10 42 invasive invasive JJ cord-298525-hhcfrjrn 10 43 diagnosis diagnosis NN cord-298525-hhcfrjrn 10 44 of of IN cord-298525-hhcfrjrn 10 45 infectious infectious JJ cord-298525-hhcfrjrn 10 46 disease disease NN cord-298525-hhcfrjrn 10 47 . . . cord-298525-hhcfrjrn 11 1 The the DT cord-298525-hhcfrjrn 11 2 origin origin NN cord-298525-hhcfrjrn 11 3 of of IN cord-298525-hhcfrjrn 11 4 the the DT cord-298525-hhcfrjrn 11 5 phrase phrase NN cord-298525-hhcfrjrn 11 6 " " `` cord-298525-hhcfrjrn 11 7 the the DT cord-298525-hhcfrjrn 11 8 eyes eye NNS cord-298525-hhcfrjrn 11 9 are be VBP cord-298525-hhcfrjrn 11 10 the the DT cord-298525-hhcfrjrn 11 11 window window NN cord-298525-hhcfrjrn 11 12 to to IN cord-298525-hhcfrjrn 11 13 the the DT cord-298525-hhcfrjrn 11 14 soul soul NN cord-298525-hhcfrjrn 11 15 " " '' cord-298525-hhcfrjrn 11 16 is be VBZ cord-298525-hhcfrjrn 11 17 attributed attribute VBN cord-298525-hhcfrjrn 11 18 to to IN cord-298525-hhcfrjrn 11 19 the the DT cord-298525-hhcfrjrn 11 20 Roman Roman NNP cord-298525-hhcfrjrn 11 21 Consul Consul NNP cord-298525-hhcfrjrn 11 22 Cicero Cicero NNP cord-298525-hhcfrjrn 11 23 , , , cord-298525-hhcfrjrn 11 24 but but CC cord-298525-hhcfrjrn 11 25 during during IN cord-298525-hhcfrjrn 11 26 the the DT cord-298525-hhcfrjrn 11 27 past past JJ cord-298525-hhcfrjrn 11 28 three three CD cord-298525-hhcfrjrn 11 29 decades decade NNS cord-298525-hhcfrjrn 11 30 the the DT cord-298525-hhcfrjrn 11 31 ability ability NN cord-298525-hhcfrjrn 11 32 of of IN cord-298525-hhcfrjrn 11 33 the the DT cord-298525-hhcfrjrn 11 34 eye eye NN cord-298525-hhcfrjrn 11 35 to to TO cord-298525-hhcfrjrn 11 36 act act VB cord-298525-hhcfrjrn 11 37 as as IN cord-298525-hhcfrjrn 11 38 a a DT cord-298525-hhcfrjrn 11 39 window window NN cord-298525-hhcfrjrn 11 40 into into IN cord-298525-hhcfrjrn 11 41 nervous nervous JJ cord-298525-hhcfrjrn 11 42 system system NN cord-298525-hhcfrjrn 11 43 function function NN cord-298525-hhcfrjrn 11 44 has have VBZ cord-298525-hhcfrjrn 11 45 been be VBN cord-298525-hhcfrjrn 11 46 exploited exploit VBN cord-298525-hhcfrjrn 11 47 for for IN cord-298525-hhcfrjrn 11 48 a a DT cord-298525-hhcfrjrn 11 49 wide wide JJ cord-298525-hhcfrjrn 11 50 range range NN cord-298525-hhcfrjrn 11 51 of of IN cord-298525-hhcfrjrn 11 52 clinical clinical JJ cord-298525-hhcfrjrn 11 53 applications application NNS cord-298525-hhcfrjrn 11 54 , , , cord-298525-hhcfrjrn 11 55 including include VBG cord-298525-hhcfrjrn 11 56 mental mental JJ cord-298525-hhcfrjrn 11 57 health health NN cord-298525-hhcfrjrn 11 58 and and CC cord-298525-hhcfrjrn 11 59 neurodegenerative neurodegenerative JJ cord-298525-hhcfrjrn 11 60 disorders disorder NNS cord-298525-hhcfrjrn 11 61 , , , cord-298525-hhcfrjrn 11 62 as as RB cord-298525-hhcfrjrn 11 63 well well RB cord-298525-hhcfrjrn 11 64 as as IN cord-298525-hhcfrjrn 11 65 exposure exposure NN cord-298525-hhcfrjrn 11 66 to to IN cord-298525-hhcfrjrn 11 67 toxic toxic JJ cord-298525-hhcfrjrn 11 68 or or CC cord-298525-hhcfrjrn 11 69 illicit illicit JJ cord-298525-hhcfrjrn 11 70 substances substance NNS cord-298525-hhcfrjrn 11 71 and and CC cord-298525-hhcfrjrn 11 72 trauma trauma NN cord-298525-hhcfrjrn 11 73 . . . cord-298525-hhcfrjrn 12 1 The the DT cord-298525-hhcfrjrn 12 2 pupillary pupillary JJ cord-298525-hhcfrjrn 12 3 light light JJ cord-298525-hhcfrjrn 12 4 reflex reflex NN cord-298525-hhcfrjrn 12 5 ( ( -LRB- cord-298525-hhcfrjrn 12 6 PLR PLR NNP cord-298525-hhcfrjrn 12 7 ) ) -RRB- cord-298525-hhcfrjrn 12 8 describes describe VBZ cord-298525-hhcfrjrn 12 9 the the DT cord-298525-hhcfrjrn 12 10 constriction constriction NN cord-298525-hhcfrjrn 12 11 and and CC cord-298525-hhcfrjrn 12 12 subsequent subsequent JJ cord-298525-hhcfrjrn 12 13 dilation dilation NN cord-298525-hhcfrjrn 12 14 of of IN cord-298525-hhcfrjrn 12 15 the the DT cord-298525-hhcfrjrn 12 16 pupil pupil NN cord-298525-hhcfrjrn 12 17 in in IN cord-298525-hhcfrjrn 12 18 response response NN cord-298525-hhcfrjrn 12 19 to to IN cord-298525-hhcfrjrn 12 20 light light NN cord-298525-hhcfrjrn 12 21 , , , cord-298525-hhcfrjrn 12 22 which which WDT cord-298525-hhcfrjrn 12 23 not not RB cord-298525-hhcfrjrn 12 24 only only RB cord-298525-hhcfrjrn 12 25 serves serve VBZ cord-298525-hhcfrjrn 12 26 as as IN cord-298525-hhcfrjrn 12 27 a a DT cord-298525-hhcfrjrn 12 28 major major JJ cord-298525-hhcfrjrn 12 29 determination determination NN cord-298525-hhcfrjrn 12 30 of of IN cord-298525-hhcfrjrn 12 31 retinal retinal JJ cord-298525-hhcfrjrn 12 32 image image NN cord-298525-hhcfrjrn 12 33 quality quality NN cord-298525-hhcfrjrn 12 34 [ [ -LRB- cord-298525-hhcfrjrn 12 35 1 1 CD cord-298525-hhcfrjrn 12 36 , , , cord-298525-hhcfrjrn 12 37 2 2 CD cord-298525-hhcfrjrn 12 38 ] ] -RRB- cord-298525-hhcfrjrn 12 39 , , , cord-298525-hhcfrjrn 12 40 but but CC cord-298525-hhcfrjrn 12 41 also also RB cord-298525-hhcfrjrn 12 42 provides provide VBZ cord-298525-hhcfrjrn 12 43 an an DT cord-298525-hhcfrjrn 12 44 important important JJ cord-298525-hhcfrjrn 12 45 metric metric NN cord-298525-hhcfrjrn 12 46 of of IN cord-298525-hhcfrjrn 12 47 autonomic autonomic JJ cord-298525-hhcfrjrn 12 48 nervous nervous JJ cord-298525-hhcfrjrn 12 49 system system NN cord-298525-hhcfrjrn 12 50 function function NN cord-298525-hhcfrjrn 12 51 [ [ -LRB- cord-298525-hhcfrjrn 12 52 3 3 CD cord-298525-hhcfrjrn 12 53 ] ] -RRB- cord-298525-hhcfrjrn 12 54 . . . cord-298525-hhcfrjrn 13 1 As as IN cord-298525-hhcfrjrn 13 2 such such JJ cord-298525-hhcfrjrn 13 3 , , , cord-298525-hhcfrjrn 13 4 measurement measurement NN cord-298525-hhcfrjrn 13 5 of of IN cord-298525-hhcfrjrn 13 6 the the DT cord-298525-hhcfrjrn 13 7 pupil pupil NN cord-298525-hhcfrjrn 13 8 's 's POS cord-298525-hhcfrjrn 13 9 response response NN cord-298525-hhcfrjrn 13 10 to to IN cord-298525-hhcfrjrn 13 11 light light NN cord-298525-hhcfrjrn 13 12 serves serve VBZ cord-298525-hhcfrjrn 13 13 as as IN cord-298525-hhcfrjrn 13 14 a a DT cord-298525-hhcfrjrn 13 15 non non JJ cord-298525-hhcfrjrn 13 16 - - JJ cord-298525-hhcfrjrn 13 17 invasive invasive JJ cord-298525-hhcfrjrn 13 18 tool tool NN cord-298525-hhcfrjrn 13 19 for for IN cord-298525-hhcfrjrn 13 20 basic basic JJ cord-298525-hhcfrjrn 13 21 neuroscience neuroscience NN cord-298525-hhcfrjrn 13 22 research research NN cord-298525-hhcfrjrn 13 23 and and CC cord-298525-hhcfrjrn 13 24 the the DT cord-298525-hhcfrjrn 13 25 study study NN cord-298525-hhcfrjrn 13 26 of of IN cord-298525-hhcfrjrn 13 27 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 13 28 and and CC cord-298525-hhcfrjrn 13 29 sympathetic sympathetic JJ cord-298525-hhcfrjrn 13 30 balance balance NN cord-298525-hhcfrjrn 13 31 . . . cord-298525-hhcfrjrn 14 1 The the DT cord-298525-hhcfrjrn 14 2 pupil pupil NN cord-298525-hhcfrjrn 14 3 has have VBZ cord-298525-hhcfrjrn 14 4 a a DT cord-298525-hhcfrjrn 14 5 large large JJ cord-298525-hhcfrjrn 14 6 dynamic dynamic JJ cord-298525-hhcfrjrn 14 7 range range NN cord-298525-hhcfrjrn 14 8 , , , cord-298525-hhcfrjrn 14 9 typically typically RB cord-298525-hhcfrjrn 14 10 from from IN cord-298525-hhcfrjrn 14 11 7.5 7.5 CD cord-298525-hhcfrjrn 14 12 - - SYM cord-298525-hhcfrjrn 14 13 8 8 CD cord-298525-hhcfrjrn 14 14 mm mm NN cord-298525-hhcfrjrn 14 15 diameter diameter NN cord-298525-hhcfrjrn 14 16 at at IN cord-298525-hhcfrjrn 14 17 full full JJ cord-298525-hhcfrjrn 14 18 mydriasis mydriasis NN cord-298525-hhcfrjrn 14 19 to to IN cord-298525-hhcfrjrn 14 20 1.5 1.5 CD cord-298525-hhcfrjrn 14 21 - - SYM cord-298525-hhcfrjrn 14 22 2 2 CD cord-298525-hhcfrjrn 14 23 mm mm NN cord-298525-hhcfrjrn 14 24 diameter diameter NN cord-298525-hhcfrjrn 14 25 at at IN cord-298525-hhcfrjrn 14 26 full full JJ cord-298525-hhcfrjrn 14 27 miosis miosis NN cord-298525-hhcfrjrn 14 28 , , , cord-298525-hhcfrjrn 14 29 and and CC cord-298525-hhcfrjrn 14 30 is be VBZ cord-298525-hhcfrjrn 14 31 controlled control VBN cord-298525-hhcfrjrn 14 32 by by IN cord-298525-hhcfrjrn 14 33 the the DT cord-298525-hhcfrjrn 14 34 antagonistic antagonistic JJ cord-298525-hhcfrjrn 14 35 actions action NNS cord-298525-hhcfrjrn 14 36 of of IN cord-298525-hhcfrjrn 14 37 the the DT cord-298525-hhcfrjrn 14 38 iris iris NNP cord-298525-hhcfrjrn 14 39 sphincter sphincter NN cord-298525-hhcfrjrn 14 40 and and CC cord-298525-hhcfrjrn 14 41 dilator dilator NN cord-298525-hhcfrjrn 14 42 muscles muscle NNS cord-298525-hhcfrjrn 14 43 [ [ -LRB- cord-298525-hhcfrjrn 14 44 4 4 CD cord-298525-hhcfrjrn 14 45 ] ] -RRB- cord-298525-hhcfrjrn 14 46 . . . cord-298525-hhcfrjrn 15 1 The the DT cord-298525-hhcfrjrn 15 2 sphincter sphincter NN cord-298525-hhcfrjrn 15 3 and and CC cord-298525-hhcfrjrn 15 4 dilator dilator NN cord-298525-hhcfrjrn 15 5 are be VBP cord-298525-hhcfrjrn 15 6 innervated innervate VBN cord-298525-hhcfrjrn 15 7 by by IN cord-298525-hhcfrjrn 15 8 the the DT cord-298525-hhcfrjrn 15 9 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 15 10 and and CC cord-298525-hhcfrjrn 15 11 sympathetic sympathetic JJ cord-298525-hhcfrjrn 15 12 nervous nervous JJ cord-298525-hhcfrjrn 15 13 systems system NNS cord-298525-hhcfrjrn 15 14 , , , cord-298525-hhcfrjrn 15 15 respectively respectively RB cord-298525-hhcfrjrn 15 16 ; ; : cord-298525-hhcfrjrn 15 17 thus thus RB cord-298525-hhcfrjrn 15 18 , , , cord-298525-hhcfrjrn 15 19 different different JJ cord-298525-hhcfrjrn 15 20 parameters parameter NNS cord-298525-hhcfrjrn 15 21 of of IN cord-298525-hhcfrjrn 15 22 the the DT cord-298525-hhcfrjrn 15 23 PLR plr NN cord-298525-hhcfrjrn 15 24 can can MD cord-298525-hhcfrjrn 15 25 be be VB cord-298525-hhcfrjrn 15 26 used use VBN cord-298525-hhcfrjrn 15 27 as as IN cord-298525-hhcfrjrn 15 28 indicators indicator NNS cord-298525-hhcfrjrn 15 29 for for IN cord-298525-hhcfrjrn 15 30 either either CC cord-298525-hhcfrjrn 15 31 sympathetic sympathetic JJ cord-298525-hhcfrjrn 15 32 or or CC cord-298525-hhcfrjrn 15 33 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 15 34 modulation modulation NN cord-298525-hhcfrjrn 15 35 . . . cord-298525-hhcfrjrn 16 1 Factors factor NNS cord-298525-hhcfrjrn 16 2 which which WDT cord-298525-hhcfrjrn 16 3 affect affect VBP cord-298525-hhcfrjrn 16 4 average average JJ cord-298525-hhcfrjrn 16 5 pupil pupil NN cord-298525-hhcfrjrn 16 6 diameter diameter NN cord-298525-hhcfrjrn 16 7 include include VBP cord-298525-hhcfrjrn 16 8 age age NN cord-298525-hhcfrjrn 16 9 , , , cord-298525-hhcfrjrn 16 10 sex sex NN cord-298525-hhcfrjrn 16 11 , , , cord-298525-hhcfrjrn 16 12 iris iris NNP cord-298525-hhcfrjrn 16 13 colour colour NN cord-298525-hhcfrjrn 16 14 , , , cord-298525-hhcfrjrn 16 15 retinal retinal JJ cord-298525-hhcfrjrn 16 16 and and CC cord-298525-hhcfrjrn 16 17 optic optic JJ cord-298525-hhcfrjrn 16 18 nerve nerve NN cord-298525-hhcfrjrn 16 19 health health NN cord-298525-hhcfrjrn 16 20 and and CC cord-298525-hhcfrjrn 16 21 optical optical JJ cord-298525-hhcfrjrn 16 22 media medium NNS cord-298525-hhcfrjrn 16 23 clarity clarity NN cord-298525-hhcfrjrn 16 24 [ [ -LRB- cord-298525-hhcfrjrn 16 25 5 5 CD cord-298525-hhcfrjrn 16 26 ] ] -RRB- cord-298525-hhcfrjrn 16 27 ; ; : cord-298525-hhcfrjrn 16 28 however however RB cord-298525-hhcfrjrn 16 29 , , , cord-298525-hhcfrjrn 16 30 the the DT cord-298525-hhcfrjrn 16 31 most most RBS cord-298525-hhcfrjrn 16 32 powerful powerful JJ cord-298525-hhcfrjrn 16 33 determinant determinant NN cord-298525-hhcfrjrn 16 34 of of IN cord-298525-hhcfrjrn 16 35 pupil pupil NN cord-298525-hhcfrjrn 16 36 size size NN cord-298525-hhcfrjrn 16 37 is be VBZ cord-298525-hhcfrjrn 16 38 ambient ambient JJ cord-298525-hhcfrjrn 16 39 light light JJ cord-298525-hhcfrjrn 16 40 level level NN cord-298525-hhcfrjrn 16 41 . . . cord-298525-hhcfrjrn 17 1 Figure figure NN cord-298525-hhcfrjrn 17 2 1 1 CD cord-298525-hhcfrjrn 17 3 . . . cord-298525-hhcfrjrn 18 1 Schematic Schematic NNP cord-298525-hhcfrjrn 18 2 of of IN cord-298525-hhcfrjrn 18 3 the the DT cord-298525-hhcfrjrn 18 4 pupillogram pupillogram NNP cord-298525-hhcfrjrn 18 5 ( ( -LRB- cord-298525-hhcfrjrn 18 6 blue blue JJ cord-298525-hhcfrjrn 18 7 line line NN cord-298525-hhcfrjrn 18 8 ) ) -RRB- cord-298525-hhcfrjrn 18 9 and and CC cord-298525-hhcfrjrn 18 10 associated associate VBD cord-298525-hhcfrjrn 18 11 PLR plr NN cord-298525-hhcfrjrn 18 12 parameters parameter NNS cord-298525-hhcfrjrn 18 13 . . . cord-298525-hhcfrjrn 19 1 The the DT cord-298525-hhcfrjrn 19 2 light light JJ cord-298525-hhcfrjrn 19 3 stimulus stimulus NN cord-298525-hhcfrjrn 19 4 at at IN cord-298525-hhcfrjrn 19 5 time time NN cord-298525-hhcfrjrn 19 6 zero zero CD cord-298525-hhcfrjrn 19 7 results result NNS cord-298525-hhcfrjrn 19 8 in in IN cord-298525-hhcfrjrn 19 9 a a DT cord-298525-hhcfrjrn 19 10 rapid rapid JJ cord-298525-hhcfrjrn 19 11 reduction reduction NN cord-298525-hhcfrjrn 19 12 in in IN cord-298525-hhcfrjrn 19 13 pupil pupil NN cord-298525-hhcfrjrn 19 14 diameter diameter NN cord-298525-hhcfrjrn 19 15 . . . cord-298525-hhcfrjrn 20 1 Latency Latency NNP cord-298525-hhcfrjrn 21 1 ( ( -LRB- cord-298525-hhcfrjrn 21 2 tL tL NNP cord-298525-hhcfrjrn 21 3 ) ) -RRB- cord-298525-hhcfrjrn 21 4 is be VBZ cord-298525-hhcfrjrn 21 5 calculated calculate VBN cord-298525-hhcfrjrn 21 6 as as IN cord-298525-hhcfrjrn 21 7 the the DT cord-298525-hhcfrjrn 21 8 elapsed elapsed JJ cord-298525-hhcfrjrn 21 9 time time NN cord-298525-hhcfrjrn 21 10 between between IN cord-298525-hhcfrjrn 21 11 light light JJ cord-298525-hhcfrjrn 21 12 onset onset NN cord-298525-hhcfrjrn 21 13 and and CC cord-298525-hhcfrjrn 21 14 the the DT cord-298525-hhcfrjrn 21 15 start start NN cord-298525-hhcfrjrn 21 16 of of IN cord-298525-hhcfrjrn 21 17 constriction constriction NN cord-298525-hhcfrjrn 21 18 . . . cord-298525-hhcfrjrn 22 1 The the DT cord-298525-hhcfrjrn 22 2 pupil pupil NN cord-298525-hhcfrjrn 22 3 then then RB cord-298525-hhcfrjrn 22 4 rapidly rapidly RB cord-298525-hhcfrjrn 22 5 constricts constrict VBZ cord-298525-hhcfrjrn 22 6 ( ( -LRB- cord-298525-hhcfrjrn 22 7 maximal maximal JJ cord-298525-hhcfrjrn 22 8 constriction constriction NN cord-298525-hhcfrjrn 22 9 velocity velocity NN cord-298525-hhcfrjrn 22 10 ; ; : cord-298525-hhcfrjrn 22 11 MCV MCV NNP cord-298525-hhcfrjrn 22 12 ) ) -RRB- cord-298525-hhcfrjrn 22 13 from from IN cord-298525-hhcfrjrn 22 14 the the DT cord-298525-hhcfrjrn 22 15 baseline baseline NN cord-298525-hhcfrjrn 22 16 ( ( -LRB- cord-298525-hhcfrjrn 22 17 D0 d0 NN cord-298525-hhcfrjrn 22 18 ) ) -RRB- cord-298525-hhcfrjrn 22 19 pupil pupil NN cord-298525-hhcfrjrn 22 20 diameter diameter NN cord-298525-hhcfrjrn 22 21 to to IN cord-298525-hhcfrjrn 22 22 the the DT cord-298525-hhcfrjrn 22 23 minimum minimum NN cord-298525-hhcfrjrn 22 24 ( ( -LRB- cord-298525-hhcfrjrn 22 25 Dmin Dmin NNP cord-298525-hhcfrjrn 22 26 ) ) -RRB- cord-298525-hhcfrjrn 22 27 pupil pupil NN cord-298525-hhcfrjrn 22 28 diameter diameter NN cord-298525-hhcfrjrn 22 29 ; ; : cord-298525-hhcfrjrn 22 30 the the DT cord-298525-hhcfrjrn 22 31 constriction constriction NN cord-298525-hhcfrjrn 22 32 time time NN cord-298525-hhcfrjrn 22 33 ( ( -LRB- cord-298525-hhcfrjrn 22 34 tC tC NNP cord-298525-hhcfrjrn 22 35 ) ) -RRB- cord-298525-hhcfrjrn 22 36 and and CC cord-298525-hhcfrjrn 22 37 maximum maximum JJ cord-298525-hhcfrjrn 22 38 constriction constriction NN cord-298525-hhcfrjrn 22 39 amplitude amplitude NN cord-298525-hhcfrjrn 22 40 ( ( -LRB- cord-298525-hhcfrjrn 22 41 MCA MCA NNP cord-298525-hhcfrjrn 22 42 ) ) -RRB- cord-298525-hhcfrjrn 22 43 are be VBP cord-298525-hhcfrjrn 22 44 calculated calculate VBN cord-298525-hhcfrjrn 22 45 as as IN cord-298525-hhcfrjrn 22 46 the the DT cord-298525-hhcfrjrn 22 47 time time NN cord-298525-hhcfrjrn 22 48 interval interval NN cord-298525-hhcfrjrn 22 49 and and CC cord-298525-hhcfrjrn 22 50 size size NN cord-298525-hhcfrjrn 22 51 difference difference NN cord-298525-hhcfrjrn 22 52 between between IN cord-298525-hhcfrjrn 22 53 these these DT cord-298525-hhcfrjrn 22 54 two two CD cord-298525-hhcfrjrn 22 55 values value NNS cord-298525-hhcfrjrn 22 56 , , , cord-298525-hhcfrjrn 22 57 respectively respectively RB cord-298525-hhcfrjrn 22 58 . . . cord-298525-hhcfrjrn 23 1 At at IN cord-298525-hhcfrjrn 23 2 offset offset NN cord-298525-hhcfrjrn 23 3 of of IN cord-298525-hhcfrjrn 23 4 light light JJ cord-298525-hhcfrjrn 23 5 stimulus stimulus NN cord-298525-hhcfrjrn 23 6 or or CC cord-298525-hhcfrjrn 23 7 during during IN cord-298525-hhcfrjrn 23 8 sustained sustained JJ cord-298525-hhcfrjrn 23 9 light light JJ cord-298525-hhcfrjrn 23 10 stimulation stimulation NN cord-298525-hhcfrjrn 23 11 the the DT cord-298525-hhcfrjrn 23 12 pupil pupil NN cord-298525-hhcfrjrn 23 13 undergoes undergo VBZ cord-298525-hhcfrjrn 23 14 a a DT cord-298525-hhcfrjrn 23 15 period period NN cord-298525-hhcfrjrn 23 16 of of IN cord-298525-hhcfrjrn 23 17 rapid rapid JJ cord-298525-hhcfrjrn 23 18 redilation redilation NN cord-298525-hhcfrjrn 23 19 or or CC cord-298525-hhcfrjrn 23 20 pupillary pupillary JJ cord-298525-hhcfrjrn 23 21 " " `` cord-298525-hhcfrjrn 23 22 escape escape NN cord-298525-hhcfrjrn 23 23 " " '' cord-298525-hhcfrjrn 23 24 to to IN cord-298525-hhcfrjrn 23 25 a a DT cord-298525-hhcfrjrn 23 26 partially partially RB cord-298525-hhcfrjrn 23 27 constricted constrict VBN cord-298525-hhcfrjrn 23 28 state state NN cord-298525-hhcfrjrn 23 29 . . . cord-298525-hhcfrjrn 24 1 Subsequently subsequently RB cord-298525-hhcfrjrn 24 2 the the DT cord-298525-hhcfrjrn 24 3 pupil pupil NN cord-298525-hhcfrjrn 24 4 slowly slowly RB cord-298525-hhcfrjrn 24 5 returns return VBZ cord-298525-hhcfrjrn 24 6 to to IN cord-298525-hhcfrjrn 24 7 the the DT cord-298525-hhcfrjrn 24 8 baseline baseline JJ cord-298525-hhcfrjrn 24 9 diameter diameter NN cord-298525-hhcfrjrn 24 10 . . . cord-298525-hhcfrjrn 25 1 Response response NN cord-298525-hhcfrjrn 25 2 latency latency NNP cord-298525-hhcfrjrn 25 3 describes describe VBZ cord-298525-hhcfrjrn 25 4 the the DT cord-298525-hhcfrjrn 25 5 delay delay NN cord-298525-hhcfrjrn 25 6 in in IN cord-298525-hhcfrjrn 25 7 pupil pupil NN cord-298525-hhcfrjrn 25 8 constriction constriction NN cord-298525-hhcfrjrn 25 9 following follow VBG cord-298525-hhcfrjrn 25 10 the the DT cord-298525-hhcfrjrn 25 11 onset onset NN cord-298525-hhcfrjrn 25 12 of of IN cord-298525-hhcfrjrn 25 13 a a DT cord-298525-hhcfrjrn 25 14 light light JJ cord-298525-hhcfrjrn 25 15 stimulus stimulus NN cord-298525-hhcfrjrn 25 16 , , , cord-298525-hhcfrjrn 25 17 with with IN cord-298525-hhcfrjrn 25 18 the the DT cord-298525-hhcfrjrn 25 19 latency latency NN cord-298525-hhcfrjrn 25 20 shortening shortening NN cord-298525-hhcfrjrn 25 21 as as IN cord-298525-hhcfrjrn 25 22 light light JJ cord-298525-hhcfrjrn 25 23 intensity intensity NN cord-298525-hhcfrjrn 25 24 increases increase NNS cord-298525-hhcfrjrn 25 25 , , , cord-298525-hhcfrjrn 25 26 to to IN cord-298525-hhcfrjrn 25 27 a a DT cord-298525-hhcfrjrn 25 28 minimum minimum NN cord-298525-hhcfrjrn 25 29 of of IN cord-298525-hhcfrjrn 25 30 180 180 CD cord-298525-hhcfrjrn 25 31 - - SYM cord-298525-hhcfrjrn 25 32 230 230 CD cord-298525-hhcfrjrn 25 33 ms ms NNP cord-298525-hhcfrjrn 25 34 [ [ -LRB- cord-298525-hhcfrjrn 25 35 7 7 CD cord-298525-hhcfrjrn 25 36 , , , cord-298525-hhcfrjrn 25 37 8 8 CD cord-298525-hhcfrjrn 25 38 ] ] -RRB- cord-298525-hhcfrjrn 25 39 . . . cord-298525-hhcfrjrn 26 1 The the DT cord-298525-hhcfrjrn 26 2 latency latency NN cord-298525-hhcfrjrn 26 3 period period NN cord-298525-hhcfrjrn 26 4 is be VBZ cord-298525-hhcfrjrn 26 5 due due JJ cord-298525-hhcfrjrn 26 6 to to IN cord-298525-hhcfrjrn 26 7 the the DT cord-298525-hhcfrjrn 26 8 delay delay NN cord-298525-hhcfrjrn 26 9 in in IN cord-298525-hhcfrjrn 26 10 iris iris JJ cord-298525-hhcfrjrn 26 11 smooth smooth JJ cord-298525-hhcfrjrn 26 12 muscle muscle NN cord-298525-hhcfrjrn 26 13 contraction contraction NN cord-298525-hhcfrjrn 26 14 and and CC cord-298525-hhcfrjrn 26 15 to to IN cord-298525-hhcfrjrn 26 16 a a DT cord-298525-hhcfrjrn 26 17 lesser less JJR cord-298525-hhcfrjrn 26 18 extent extent NN cord-298525-hhcfrjrn 26 19 the the DT cord-298525-hhcfrjrn 26 20 temporal temporal JJ cord-298525-hhcfrjrn 26 21 dynamics dynamic NNS cord-298525-hhcfrjrn 26 22 of of IN cord-298525-hhcfrjrn 26 23 retinal retinal JJ cord-298525-hhcfrjrn 26 24 output output NN cord-298525-hhcfrjrn 26 25 and and CC cord-298525-hhcfrjrn 26 26 innervation innervation NN cord-298525-hhcfrjrn 26 27 pathways pathway NNS cord-298525-hhcfrjrn 26 28 [ [ -LRB- cord-298525-hhcfrjrn 26 29 7 7 CD cord-298525-hhcfrjrn 26 30 , , , cord-298525-hhcfrjrn 26 31 8 8 CD cord-298525-hhcfrjrn 26 32 ] ] -RRB- cord-298525-hhcfrjrn 26 33 . . . cord-298525-hhcfrjrn 27 1 The the DT cord-298525-hhcfrjrn 27 2 latency latency NN cord-298525-hhcfrjrn 27 3 period period NN cord-298525-hhcfrjrn 27 4 is be VBZ cord-298525-hhcfrjrn 27 5 followed follow VBN cord-298525-hhcfrjrn 27 6 by by IN cord-298525-hhcfrjrn 27 7 a a DT cord-298525-hhcfrjrn 27 8 period period NN cord-298525-hhcfrjrn 27 9 of of IN cord-298525-hhcfrjrn 27 10 rapid rapid JJ cord-298525-hhcfrjrn 27 11 constriction constriction NN cord-298525-hhcfrjrn 27 12 of of IN cord-298525-hhcfrjrn 27 13 the the DT cord-298525-hhcfrjrn 27 14 pupil pupil NN cord-298525-hhcfrjrn 27 15 until until IN cord-298525-hhcfrjrn 27 16 it -PRON- PRP cord-298525-hhcfrjrn 27 17 reaches reach VBZ cord-298525-hhcfrjrn 27 18 the the DT cord-298525-hhcfrjrn 27 19 maximum maximum JJ cord-298525-hhcfrjrn 27 20 constriction constriction NN cord-298525-hhcfrjrn 27 21 velocity velocity NN cord-298525-hhcfrjrn 27 22 ( ( -LRB- cord-298525-hhcfrjrn 27 23 MCV MCV NNP cord-298525-hhcfrjrn 27 24 ) ) -RRB- cord-298525-hhcfrjrn 27 25 , , , cord-298525-hhcfrjrn 27 26 after after IN cord-298525-hhcfrjrn 27 27 which which WDT cord-298525-hhcfrjrn 27 28 constriction constriction NN cord-298525-hhcfrjrn 27 29 slows slow VBZ cord-298525-hhcfrjrn 27 30 until until IN cord-298525-hhcfrjrn 27 31 the the DT cord-298525-hhcfrjrn 27 32 minimum minimum JJ cord-298525-hhcfrjrn 27 33 pupil pupil NN cord-298525-hhcfrjrn 27 34 diameter diameter NN cord-298525-hhcfrjrn 27 35 is be VBZ cord-298525-hhcfrjrn 27 36 reached reach VBN cord-298525-hhcfrjrn 27 37 . . . cord-298525-hhcfrjrn 28 1 The the DT cord-298525-hhcfrjrn 28 2 onset onset NN cord-298525-hhcfrjrn 28 3 of of IN cord-298525-hhcfrjrn 28 4 pupil pupil NN cord-298525-hhcfrjrn 28 5 contraction contraction NN cord-298525-hhcfrjrn 28 6 can can MD cord-298525-hhcfrjrn 28 7 be be VB cord-298525-hhcfrjrn 28 8 determined determine VBN cord-298525-hhcfrjrn 28 9 using use VBG cord-298525-hhcfrjrn 28 10 velocity velocity NN cord-298525-hhcfrjrn 28 11 and and CC cord-298525-hhcfrjrn 28 12 acceleration acceleration NN cord-298525-hhcfrjrn 28 13 analysis analysis NN cord-298525-hhcfrjrn 28 14 [ [ -LRB- cord-298525-hhcfrjrn 28 15 9 9 CD cord-298525-hhcfrjrn 28 16 ] ] -RRB- cord-298525-hhcfrjrn 28 17 . . . cord-298525-hhcfrjrn 29 1 The the DT cord-298525-hhcfrjrn 29 2 maximum maximum JJ cord-298525-hhcfrjrn 29 3 constriction constriction NN cord-298525-hhcfrjrn 29 4 velocity velocity NN cord-298525-hhcfrjrn 29 5 varies vary VBZ cord-298525-hhcfrjrn 29 6 with with IN cord-298525-hhcfrjrn 29 7 light light JJ cord-298525-hhcfrjrn 29 8 stimulus stimulus NN cord-298525-hhcfrjrn 29 9 intensity intensity NN cord-298525-hhcfrjrn 29 10 , , , cord-298525-hhcfrjrn 29 11 duration duration NN cord-298525-hhcfrjrn 29 12 , , , cord-298525-hhcfrjrn 29 13 spectral spectral JJ cord-298525-hhcfrjrn 29 14 composition composition NN cord-298525-hhcfrjrn 29 15 , , , cord-298525-hhcfrjrn 29 16 retinal retinal JJ cord-298525-hhcfrjrn 29 17 size size NN cord-298525-hhcfrjrn 29 18 and and CC cord-298525-hhcfrjrn 29 19 location location NN cord-298525-hhcfrjrn 29 20 [ [ -LRB- cord-298525-hhcfrjrn 29 21 10 10 CD cord-298525-hhcfrjrn 29 22 ] ] -RRB- cord-298525-hhcfrjrn 29 23 . . . cord-298525-hhcfrjrn 30 1 The the DT cord-298525-hhcfrjrn 30 2 maximum maximum JJ cord-298525-hhcfrjrn 30 3 constriction constriction NN cord-298525-hhcfrjrn 30 4 amplitude amplitude NN cord-298525-hhcfrjrn 30 5 ( ( -LRB- cord-298525-hhcfrjrn 30 6 MCA MCA NNP cord-298525-hhcfrjrn 30 7 ) ) -RRB- cord-298525-hhcfrjrn 30 8 represents represent VBZ cord-298525-hhcfrjrn 30 9 the the DT cord-298525-hhcfrjrn 30 10 difference difference NN cord-298525-hhcfrjrn 30 11 between between IN cord-298525-hhcfrjrn 30 12 the the DT cord-298525-hhcfrjrn 30 13 baseline baseline NN cord-298525-hhcfrjrn 30 14 and and CC cord-298525-hhcfrjrn 30 15 minimum minimum JJ cord-298525-hhcfrjrn 30 16 pupil pupil NN cord-298525-hhcfrjrn 30 17 diameter diameter NN cord-298525-hhcfrjrn 30 18 . . . cord-298525-hhcfrjrn 31 1 However however RB cord-298525-hhcfrjrn 31 2 , , , cord-298525-hhcfrjrn 31 3 the the DT cord-298525-hhcfrjrn 31 4 baseline baseline JJ cord-298525-hhcfrjrn 31 5 pupil pupil NN cord-298525-hhcfrjrn 31 6 diameter diameter NN cord-298525-hhcfrjrn 31 7 can can MD cord-298525-hhcfrjrn 31 8 be be VB cord-298525-hhcfrjrn 31 9 affected affect VBN cord-298525-hhcfrjrn 31 10 by by IN cord-298525-hhcfrjrn 31 11 a a DT cord-298525-hhcfrjrn 31 12 number number NN cord-298525-hhcfrjrn 31 13 of of IN cord-298525-hhcfrjrn 31 14 factors factor NNS cord-298525-hhcfrjrn 31 15 and and CC cord-298525-hhcfrjrn 31 16 can can MD cord-298525-hhcfrjrn 31 17 influence influence VB cord-298525-hhcfrjrn 31 18 the the DT cord-298525-hhcfrjrn 31 19 MCA MCA NNP cord-298525-hhcfrjrn 31 20 ( ( -LRB- cord-298525-hhcfrjrn 31 21 a a DT cord-298525-hhcfrjrn 31 22 smaller small JJR cord-298525-hhcfrjrn 31 23 MCA MCA NNP cord-298525-hhcfrjrn 31 24 is be VBZ cord-298525-hhcfrjrn 31 25 observed observe VBN cord-298525-hhcfrjrn 31 26 with with IN cord-298525-hhcfrjrn 31 27 a a DT cord-298525-hhcfrjrn 31 28 smaller small JJR cord-298525-hhcfrjrn 31 29 baseline baseline JJ cord-298525-hhcfrjrn 31 30 pupil pupil NN cord-298525-hhcfrjrn 31 31 diameter diameter NN cord-298525-hhcfrjrn 31 32 ) ) -RRB- cord-298525-hhcfrjrn 31 33 . . . cord-298525-hhcfrjrn 32 1 Therefore therefore RB cord-298525-hhcfrjrn 32 2 , , , cord-298525-hhcfrjrn 32 3 the the DT cord-298525-hhcfrjrn 32 4 MCA MCA NNP cord-298525-hhcfrjrn 32 5 should should MD cord-298525-hhcfrjrn 32 6 be be VB cord-298525-hhcfrjrn 32 7 normalised normalise VBN cord-298525-hhcfrjrn 32 8 to to IN cord-298525-hhcfrjrn 32 9 baseline baseline JJ cord-298525-hhcfrjrn 32 10 pupil pupil NN cord-298525-hhcfrjrn 32 11 diameter diameter NN cord-298525-hhcfrjrn 32 12 to to TO cord-298525-hhcfrjrn 32 13 account account VB cord-298525-hhcfrjrn 32 14 for for IN cord-298525-hhcfrjrn 32 15 this this DT cord-298525-hhcfrjrn 32 16 effect effect NN cord-298525-hhcfrjrn 32 17 [ [ -LRB- cord-298525-hhcfrjrn 32 18 6 6 CD cord-298525-hhcfrjrn 32 19 ] ] -RRB- cord-298525-hhcfrjrn 32 20 . . . cord-298525-hhcfrjrn 33 1 After after IN cord-298525-hhcfrjrn 33 2 this this DT cord-298525-hhcfrjrn 33 3 peak peak NN cord-298525-hhcfrjrn 33 4 constriction constriction NN cord-298525-hhcfrjrn 33 5 , , , cord-298525-hhcfrjrn 33 6 the the DT cord-298525-hhcfrjrn 33 7 pupil pupil NN cord-298525-hhcfrjrn 33 8 quickly quickly RB cord-298525-hhcfrjrn 33 9 redilates redilate VBZ cord-298525-hhcfrjrn 33 10 or or CC cord-298525-hhcfrjrn 33 11 " " `` cord-298525-hhcfrjrn 33 12 escapes escape VBZ cord-298525-hhcfrjrn 33 13 " " '' cord-298525-hhcfrjrn 33 14 to to IN cord-298525-hhcfrjrn 33 15 a a DT cord-298525-hhcfrjrn 33 16 partially partially RB cord-298525-hhcfrjrn 33 17 constricted constrict VBN cord-298525-hhcfrjrn 33 18 state state NN cord-298525-hhcfrjrn 33 19 during during IN cord-298525-hhcfrjrn 33 20 a a DT cord-298525-hhcfrjrn 33 21 prolonged prolonged JJ cord-298525-hhcfrjrn 33 22 light light JJ cord-298525-hhcfrjrn 33 23 stimulus stimulus NN cord-298525-hhcfrjrn 33 24 lasting last VBG cord-298525-hhcfrjrn 33 25 from from IN cord-298525-hhcfrjrn 33 26 1 1 CD cord-298525-hhcfrjrn 33 27 - - SYM cord-298525-hhcfrjrn 33 28 2 2 CD cord-298525-hhcfrjrn 33 29 up up IN cord-298525-hhcfrjrn 33 30 to to TO cord-298525-hhcfrjrn 33 31 100 100 CD cord-298525-hhcfrjrn 33 32 s s NNPS cord-298525-hhcfrjrn 33 33 , , , cord-298525-hhcfrjrn 33 34 before before IN cord-298525-hhcfrjrn 33 35 slowly slowly RB cord-298525-hhcfrjrn 33 36 redilating redilate VBG cord-298525-hhcfrjrn 33 37 to to IN cord-298525-hhcfrjrn 33 38 the the DT cord-298525-hhcfrjrn 33 39 initial initial JJ cord-298525-hhcfrjrn 33 40 size size NN cord-298525-hhcfrjrn 33 41 [ [ -LRB- cord-298525-hhcfrjrn 33 42 11 11 CD cord-298525-hhcfrjrn 33 43 ] ] -RRB- cord-298525-hhcfrjrn 33 44 . . . cord-298525-hhcfrjrn 34 1 In in IN cord-298525-hhcfrjrn 34 2 addition addition NN cord-298525-hhcfrjrn 34 3 to to IN cord-298525-hhcfrjrn 34 4 the the DT cord-298525-hhcfrjrn 34 5 dynamic dynamic JJ cord-298525-hhcfrjrn 34 6 phases phase NNS cord-298525-hhcfrjrn 34 7 of of IN cord-298525-hhcfrjrn 34 8 the the DT cord-298525-hhcfrjrn 34 9 PLR plr NN cord-298525-hhcfrjrn 34 10 during during IN cord-298525-hhcfrjrn 34 11 light light JJ cord-298525-hhcfrjrn 34 12 stimulation stimulation NN cord-298525-hhcfrjrn 34 13 , , , cord-298525-hhcfrjrn 34 14 there there EX cord-298525-hhcfrjrn 34 15 is be VBZ cord-298525-hhcfrjrn 34 16 also also RB cord-298525-hhcfrjrn 34 17 a a DT cord-298525-hhcfrjrn 34 18 sustained sustained JJ cord-298525-hhcfrjrn 34 19 component component NN cord-298525-hhcfrjrn 34 20 [ [ -LRB- cord-298525-hhcfrjrn 34 21 12 12 CD cord-298525-hhcfrjrn 34 22 , , , cord-298525-hhcfrjrn 34 23 13 13 CD cord-298525-hhcfrjrn 34 24 ] ] -RRB- cord-298525-hhcfrjrn 34 25 . . . cord-298525-hhcfrjrn 35 1 Both both DT cord-298525-hhcfrjrn 35 2 outer outer JJ cord-298525-hhcfrjrn 35 3 and and CC cord-298525-hhcfrjrn 35 4 inner inner JJ cord-298525-hhcfrjrn 35 5 photoreceptors photoreceptor NNS cord-298525-hhcfrjrn 35 6 contribute contribute VBP cord-298525-hhcfrjrn 35 7 to to IN cord-298525-hhcfrjrn 35 8 the the DT cord-298525-hhcfrjrn 35 9 early early JJ cord-298525-hhcfrjrn 35 10 sustained sustain VBN cord-298525-hhcfrjrn 35 11 post- post- NN cord-298525-hhcfrjrn 36 1 Figure figure NN cord-298525-hhcfrjrn 36 2 1 1 CD cord-298525-hhcfrjrn 36 3 . . . cord-298525-hhcfrjrn 37 1 Schematic Schematic NNP cord-298525-hhcfrjrn 37 2 of of IN cord-298525-hhcfrjrn 37 3 the the DT cord-298525-hhcfrjrn 37 4 pupillogram pupillogram NNP cord-298525-hhcfrjrn 37 5 ( ( -LRB- cord-298525-hhcfrjrn 37 6 blue blue JJ cord-298525-hhcfrjrn 37 7 line line NN cord-298525-hhcfrjrn 37 8 ) ) -RRB- cord-298525-hhcfrjrn 37 9 and and CC cord-298525-hhcfrjrn 37 10 associated associate VBD cord-298525-hhcfrjrn 37 11 PLR plr NN cord-298525-hhcfrjrn 37 12 parameters parameter NNS cord-298525-hhcfrjrn 37 13 . . . cord-298525-hhcfrjrn 38 1 The the DT cord-298525-hhcfrjrn 38 2 light light JJ cord-298525-hhcfrjrn 38 3 stimulus stimulus NN cord-298525-hhcfrjrn 38 4 at at IN cord-298525-hhcfrjrn 38 5 time time NN cord-298525-hhcfrjrn 38 6 zero zero CD cord-298525-hhcfrjrn 38 7 results result NNS cord-298525-hhcfrjrn 38 8 in in IN cord-298525-hhcfrjrn 38 9 a a DT cord-298525-hhcfrjrn 38 10 rapid rapid JJ cord-298525-hhcfrjrn 38 11 reduction reduction NN cord-298525-hhcfrjrn 38 12 in in IN cord-298525-hhcfrjrn 38 13 pupil pupil NN cord-298525-hhcfrjrn 38 14 diameter diameter NN cord-298525-hhcfrjrn 38 15 . . . cord-298525-hhcfrjrn 39 1 Latency Latency NNP cord-298525-hhcfrjrn 39 2 ( ( -LRB- cord-298525-hhcfrjrn 39 3 t t NNP cord-298525-hhcfrjrn 39 4 L L NNP cord-298525-hhcfrjrn 39 5 ) ) -RRB- cord-298525-hhcfrjrn 39 6 is be VBZ cord-298525-hhcfrjrn 39 7 calculated calculate VBN cord-298525-hhcfrjrn 39 8 as as IN cord-298525-hhcfrjrn 39 9 the the DT cord-298525-hhcfrjrn 39 10 elapsed elapsed JJ cord-298525-hhcfrjrn 39 11 time time NN cord-298525-hhcfrjrn 39 12 between between IN cord-298525-hhcfrjrn 39 13 light light JJ cord-298525-hhcfrjrn 39 14 onset onset NN cord-298525-hhcfrjrn 39 15 and and CC cord-298525-hhcfrjrn 39 16 the the DT cord-298525-hhcfrjrn 39 17 start start NN cord-298525-hhcfrjrn 39 18 of of IN cord-298525-hhcfrjrn 39 19 constriction constriction NN cord-298525-hhcfrjrn 39 20 . . . cord-298525-hhcfrjrn 40 1 The the DT cord-298525-hhcfrjrn 40 2 pupil pupil NN cord-298525-hhcfrjrn 40 3 then then RB cord-298525-hhcfrjrn 40 4 rapidly rapidly RB cord-298525-hhcfrjrn 40 5 constricts constrict VBZ cord-298525-hhcfrjrn 40 6 ( ( -LRB- cord-298525-hhcfrjrn 40 7 maximal maximal JJ cord-298525-hhcfrjrn 40 8 constriction constriction NN cord-298525-hhcfrjrn 40 9 velocity velocity NN cord-298525-hhcfrjrn 40 10 ; ; : cord-298525-hhcfrjrn 40 11 MCV MCV NNP cord-298525-hhcfrjrn 40 12 ) ) -RRB- cord-298525-hhcfrjrn 40 13 from from IN cord-298525-hhcfrjrn 40 14 the the DT cord-298525-hhcfrjrn 40 15 baseline baseline NN cord-298525-hhcfrjrn 40 16 ( ( -LRB- cord-298525-hhcfrjrn 40 17 D d NN cord-298525-hhcfrjrn 40 18 0 0 CD cord-298525-hhcfrjrn 40 19 ) ) -RRB- cord-298525-hhcfrjrn 41 1 pupil pupil NN cord-298525-hhcfrjrn 41 2 diameter diameter NN cord-298525-hhcfrjrn 41 3 to to IN cord-298525-hhcfrjrn 41 4 the the DT cord-298525-hhcfrjrn 41 5 minimum minimum NN cord-298525-hhcfrjrn 41 6 ( ( -LRB- cord-298525-hhcfrjrn 41 7 D D NNP cord-298525-hhcfrjrn 41 8 min min NN cord-298525-hhcfrjrn 41 9 ) ) -RRB- cord-298525-hhcfrjrn 41 10 pupil pupil NN cord-298525-hhcfrjrn 41 11 diameter diameter NN cord-298525-hhcfrjrn 41 12 ; ; : cord-298525-hhcfrjrn 41 13 the the DT cord-298525-hhcfrjrn 41 14 constriction constriction NN cord-298525-hhcfrjrn 41 15 time time NN cord-298525-hhcfrjrn 41 16 ( ( -LRB- cord-298525-hhcfrjrn 41 17 t t NN cord-298525-hhcfrjrn 41 18 C C NNP cord-298525-hhcfrjrn 41 19 ) ) -RRB- cord-298525-hhcfrjrn 41 20 and and CC cord-298525-hhcfrjrn 41 21 maximum maximum JJ cord-298525-hhcfrjrn 41 22 constriction constriction NN cord-298525-hhcfrjrn 41 23 amplitude amplitude NN cord-298525-hhcfrjrn 41 24 ( ( -LRB- cord-298525-hhcfrjrn 41 25 MCA MCA NNP cord-298525-hhcfrjrn 41 26 ) ) -RRB- cord-298525-hhcfrjrn 41 27 are be VBP cord-298525-hhcfrjrn 41 28 calculated calculate VBN cord-298525-hhcfrjrn 41 29 as as IN cord-298525-hhcfrjrn 41 30 the the DT cord-298525-hhcfrjrn 41 31 time time NN cord-298525-hhcfrjrn 41 32 interval interval NN cord-298525-hhcfrjrn 41 33 and and CC cord-298525-hhcfrjrn 41 34 size size NN cord-298525-hhcfrjrn 41 35 difference difference NN cord-298525-hhcfrjrn 41 36 between between IN cord-298525-hhcfrjrn 41 37 these these DT cord-298525-hhcfrjrn 41 38 two two CD cord-298525-hhcfrjrn 41 39 values value NNS cord-298525-hhcfrjrn 41 40 , , , cord-298525-hhcfrjrn 41 41 respectively respectively RB cord-298525-hhcfrjrn 41 42 . . . cord-298525-hhcfrjrn 42 1 At at IN cord-298525-hhcfrjrn 42 2 offset offset NN cord-298525-hhcfrjrn 42 3 of of IN cord-298525-hhcfrjrn 42 4 light light JJ cord-298525-hhcfrjrn 42 5 stimulus stimulus NN cord-298525-hhcfrjrn 42 6 or or CC cord-298525-hhcfrjrn 42 7 during during IN cord-298525-hhcfrjrn 42 8 sustained sustained JJ cord-298525-hhcfrjrn 42 9 light light JJ cord-298525-hhcfrjrn 42 10 stimulation stimulation NN cord-298525-hhcfrjrn 42 11 the the DT cord-298525-hhcfrjrn 42 12 pupil pupil NN cord-298525-hhcfrjrn 42 13 undergoes undergo VBZ cord-298525-hhcfrjrn 42 14 a a DT cord-298525-hhcfrjrn 42 15 period period NN cord-298525-hhcfrjrn 42 16 of of IN cord-298525-hhcfrjrn 42 17 rapid rapid JJ cord-298525-hhcfrjrn 42 18 redilation redilation NN cord-298525-hhcfrjrn 42 19 or or CC cord-298525-hhcfrjrn 42 20 pupillary pupillary JJ cord-298525-hhcfrjrn 42 21 " " `` cord-298525-hhcfrjrn 42 22 escape escape NN cord-298525-hhcfrjrn 42 23 " " '' cord-298525-hhcfrjrn 42 24 to to IN cord-298525-hhcfrjrn 42 25 a a DT cord-298525-hhcfrjrn 42 26 partially partially RB cord-298525-hhcfrjrn 42 27 constricted constrict VBN cord-298525-hhcfrjrn 42 28 state state NN cord-298525-hhcfrjrn 42 29 . . . cord-298525-hhcfrjrn 43 1 Subsequently subsequently RB cord-298525-hhcfrjrn 43 2 the the DT cord-298525-hhcfrjrn 43 3 pupil pupil NN cord-298525-hhcfrjrn 43 4 slowly slowly RB cord-298525-hhcfrjrn 43 5 returns return VBZ cord-298525-hhcfrjrn 43 6 to to IN cord-298525-hhcfrjrn 43 7 the the DT cord-298525-hhcfrjrn 43 8 baseline baseline JJ cord-298525-hhcfrjrn 43 9 diameter diameter NN cord-298525-hhcfrjrn 43 10 . . . cord-298525-hhcfrjrn 44 1 Response response NN cord-298525-hhcfrjrn 44 2 latency latency NNP cord-298525-hhcfrjrn 44 3 describes describe VBZ cord-298525-hhcfrjrn 44 4 the the DT cord-298525-hhcfrjrn 44 5 delay delay NN cord-298525-hhcfrjrn 44 6 in in IN cord-298525-hhcfrjrn 44 7 pupil pupil NN cord-298525-hhcfrjrn 44 8 constriction constriction NN cord-298525-hhcfrjrn 44 9 following follow VBG cord-298525-hhcfrjrn 44 10 the the DT cord-298525-hhcfrjrn 44 11 onset onset NN cord-298525-hhcfrjrn 44 12 of of IN cord-298525-hhcfrjrn 44 13 a a DT cord-298525-hhcfrjrn 44 14 light light JJ cord-298525-hhcfrjrn 44 15 stimulus stimulus NN cord-298525-hhcfrjrn 44 16 , , , cord-298525-hhcfrjrn 44 17 with with IN cord-298525-hhcfrjrn 44 18 the the DT cord-298525-hhcfrjrn 44 19 latency latency NN cord-298525-hhcfrjrn 44 20 shortening shortening NN cord-298525-hhcfrjrn 44 21 as as IN cord-298525-hhcfrjrn 44 22 light light JJ cord-298525-hhcfrjrn 44 23 intensity intensity NN cord-298525-hhcfrjrn 44 24 increases increase NNS cord-298525-hhcfrjrn 44 25 , , , cord-298525-hhcfrjrn 44 26 to to IN cord-298525-hhcfrjrn 44 27 a a DT cord-298525-hhcfrjrn 44 28 minimum minimum NN cord-298525-hhcfrjrn 44 29 of of IN cord-298525-hhcfrjrn 44 30 180 180 CD cord-298525-hhcfrjrn 44 31 - - SYM cord-298525-hhcfrjrn 44 32 230 230 CD cord-298525-hhcfrjrn 44 33 ms ms NNP cord-298525-hhcfrjrn 44 34 [ [ -LRB- cord-298525-hhcfrjrn 44 35 7 7 CD cord-298525-hhcfrjrn 44 36 , , , cord-298525-hhcfrjrn 44 37 8 8 CD cord-298525-hhcfrjrn 44 38 ] ] -RRB- cord-298525-hhcfrjrn 44 39 . . . cord-298525-hhcfrjrn 45 1 The the DT cord-298525-hhcfrjrn 45 2 latency latency NN cord-298525-hhcfrjrn 45 3 period period NN cord-298525-hhcfrjrn 45 4 is be VBZ cord-298525-hhcfrjrn 45 5 due due JJ cord-298525-hhcfrjrn 45 6 to to IN cord-298525-hhcfrjrn 45 7 the the DT cord-298525-hhcfrjrn 45 8 delay delay NN cord-298525-hhcfrjrn 45 9 in in IN cord-298525-hhcfrjrn 45 10 iris iris JJ cord-298525-hhcfrjrn 45 11 smooth smooth JJ cord-298525-hhcfrjrn 45 12 muscle muscle NN cord-298525-hhcfrjrn 45 13 contraction contraction NN cord-298525-hhcfrjrn 45 14 and and CC cord-298525-hhcfrjrn 45 15 to to IN cord-298525-hhcfrjrn 45 16 a a DT cord-298525-hhcfrjrn 45 17 lesser less JJR cord-298525-hhcfrjrn 45 18 extent extent NN cord-298525-hhcfrjrn 45 19 the the DT cord-298525-hhcfrjrn 45 20 temporal temporal JJ cord-298525-hhcfrjrn 45 21 dynamics dynamic NNS cord-298525-hhcfrjrn 45 22 of of IN cord-298525-hhcfrjrn 45 23 retinal retinal JJ cord-298525-hhcfrjrn 45 24 output output NN cord-298525-hhcfrjrn 45 25 and and CC cord-298525-hhcfrjrn 45 26 innervation innervation NN cord-298525-hhcfrjrn 45 27 pathways pathway NNS cord-298525-hhcfrjrn 45 28 [ [ -LRB- cord-298525-hhcfrjrn 45 29 7 7 CD cord-298525-hhcfrjrn 45 30 , , , cord-298525-hhcfrjrn 45 31 8 8 CD cord-298525-hhcfrjrn 45 32 ] ] -RRB- cord-298525-hhcfrjrn 45 33 . . . cord-298525-hhcfrjrn 46 1 The the DT cord-298525-hhcfrjrn 46 2 latency latency NN cord-298525-hhcfrjrn 46 3 period period NN cord-298525-hhcfrjrn 46 4 is be VBZ cord-298525-hhcfrjrn 46 5 followed follow VBN cord-298525-hhcfrjrn 46 6 by by IN cord-298525-hhcfrjrn 46 7 a a DT cord-298525-hhcfrjrn 46 8 period period NN cord-298525-hhcfrjrn 46 9 of of IN cord-298525-hhcfrjrn 46 10 rapid rapid JJ cord-298525-hhcfrjrn 46 11 constriction constriction NN cord-298525-hhcfrjrn 46 12 of of IN cord-298525-hhcfrjrn 46 13 the the DT cord-298525-hhcfrjrn 46 14 pupil pupil NN cord-298525-hhcfrjrn 46 15 until until IN cord-298525-hhcfrjrn 46 16 it -PRON- PRP cord-298525-hhcfrjrn 46 17 reaches reach VBZ cord-298525-hhcfrjrn 46 18 the the DT cord-298525-hhcfrjrn 46 19 maximum maximum JJ cord-298525-hhcfrjrn 46 20 constriction constriction NN cord-298525-hhcfrjrn 46 21 velocity velocity NN cord-298525-hhcfrjrn 46 22 ( ( -LRB- cord-298525-hhcfrjrn 46 23 MCV MCV NNP cord-298525-hhcfrjrn 46 24 ) ) -RRB- cord-298525-hhcfrjrn 46 25 , , , cord-298525-hhcfrjrn 46 26 after after IN cord-298525-hhcfrjrn 46 27 which which WDT cord-298525-hhcfrjrn 46 28 constriction constriction NN cord-298525-hhcfrjrn 46 29 slows slow VBZ cord-298525-hhcfrjrn 46 30 until until IN cord-298525-hhcfrjrn 46 31 the the DT cord-298525-hhcfrjrn 46 32 minimum minimum JJ cord-298525-hhcfrjrn 46 33 pupil pupil NN cord-298525-hhcfrjrn 46 34 diameter diameter NN cord-298525-hhcfrjrn 46 35 is be VBZ cord-298525-hhcfrjrn 46 36 reached reach VBN cord-298525-hhcfrjrn 46 37 . . . cord-298525-hhcfrjrn 47 1 The the DT cord-298525-hhcfrjrn 47 2 onset onset NN cord-298525-hhcfrjrn 47 3 of of IN cord-298525-hhcfrjrn 47 4 pupil pupil NN cord-298525-hhcfrjrn 47 5 contraction contraction NN cord-298525-hhcfrjrn 47 6 can can MD cord-298525-hhcfrjrn 47 7 be be VB cord-298525-hhcfrjrn 47 8 determined determine VBN cord-298525-hhcfrjrn 47 9 using use VBG cord-298525-hhcfrjrn 47 10 velocity velocity NN cord-298525-hhcfrjrn 47 11 and and CC cord-298525-hhcfrjrn 47 12 acceleration acceleration NN cord-298525-hhcfrjrn 47 13 analysis analysis NN cord-298525-hhcfrjrn 47 14 [ [ -LRB- cord-298525-hhcfrjrn 47 15 9 9 CD cord-298525-hhcfrjrn 47 16 ] ] -RRB- cord-298525-hhcfrjrn 47 17 . . . cord-298525-hhcfrjrn 48 1 The the DT cord-298525-hhcfrjrn 48 2 maximum maximum JJ cord-298525-hhcfrjrn 48 3 constriction constriction NN cord-298525-hhcfrjrn 48 4 velocity velocity NN cord-298525-hhcfrjrn 48 5 varies vary VBZ cord-298525-hhcfrjrn 48 6 with with IN cord-298525-hhcfrjrn 48 7 light light JJ cord-298525-hhcfrjrn 48 8 stimulus stimulus NN cord-298525-hhcfrjrn 48 9 intensity intensity NN cord-298525-hhcfrjrn 48 10 , , , cord-298525-hhcfrjrn 48 11 duration duration NN cord-298525-hhcfrjrn 48 12 , , , cord-298525-hhcfrjrn 48 13 spectral spectral JJ cord-298525-hhcfrjrn 48 14 composition composition NN cord-298525-hhcfrjrn 48 15 , , , cord-298525-hhcfrjrn 48 16 retinal retinal JJ cord-298525-hhcfrjrn 48 17 size size NN cord-298525-hhcfrjrn 48 18 and and CC cord-298525-hhcfrjrn 48 19 location location NN cord-298525-hhcfrjrn 48 20 [ [ -LRB- cord-298525-hhcfrjrn 48 21 10 10 CD cord-298525-hhcfrjrn 48 22 ] ] -RRB- cord-298525-hhcfrjrn 48 23 . . . cord-298525-hhcfrjrn 49 1 The the DT cord-298525-hhcfrjrn 49 2 maximum maximum JJ cord-298525-hhcfrjrn 49 3 constriction constriction NN cord-298525-hhcfrjrn 49 4 amplitude amplitude NN cord-298525-hhcfrjrn 49 5 ( ( -LRB- cord-298525-hhcfrjrn 49 6 MCA MCA NNP cord-298525-hhcfrjrn 49 7 ) ) -RRB- cord-298525-hhcfrjrn 49 8 represents represent VBZ cord-298525-hhcfrjrn 49 9 the the DT cord-298525-hhcfrjrn 49 10 difference difference NN cord-298525-hhcfrjrn 49 11 between between IN cord-298525-hhcfrjrn 49 12 the the DT cord-298525-hhcfrjrn 49 13 baseline baseline NN cord-298525-hhcfrjrn 49 14 and and CC cord-298525-hhcfrjrn 49 15 minimum minimum JJ cord-298525-hhcfrjrn 49 16 pupil pupil NN cord-298525-hhcfrjrn 49 17 diameter diameter NN cord-298525-hhcfrjrn 49 18 . . . cord-298525-hhcfrjrn 50 1 However however RB cord-298525-hhcfrjrn 50 2 , , , cord-298525-hhcfrjrn 50 3 the the DT cord-298525-hhcfrjrn 50 4 baseline baseline JJ cord-298525-hhcfrjrn 50 5 pupil pupil NN cord-298525-hhcfrjrn 50 6 diameter diameter NN cord-298525-hhcfrjrn 50 7 can can MD cord-298525-hhcfrjrn 50 8 be be VB cord-298525-hhcfrjrn 50 9 affected affect VBN cord-298525-hhcfrjrn 50 10 by by IN cord-298525-hhcfrjrn 50 11 a a DT cord-298525-hhcfrjrn 50 12 number number NN cord-298525-hhcfrjrn 50 13 of of IN cord-298525-hhcfrjrn 50 14 factors factor NNS cord-298525-hhcfrjrn 50 15 and and CC cord-298525-hhcfrjrn 50 16 can can MD cord-298525-hhcfrjrn 50 17 influence influence VB cord-298525-hhcfrjrn 50 18 the the DT cord-298525-hhcfrjrn 50 19 MCA MCA NNP cord-298525-hhcfrjrn 50 20 ( ( -LRB- cord-298525-hhcfrjrn 50 21 a a DT cord-298525-hhcfrjrn 50 22 smaller small JJR cord-298525-hhcfrjrn 50 23 MCA MCA NNP cord-298525-hhcfrjrn 50 24 is be VBZ cord-298525-hhcfrjrn 50 25 observed observe VBN cord-298525-hhcfrjrn 50 26 with with IN cord-298525-hhcfrjrn 50 27 a a DT cord-298525-hhcfrjrn 50 28 smaller small JJR cord-298525-hhcfrjrn 50 29 baseline baseline JJ cord-298525-hhcfrjrn 50 30 pupil pupil NN cord-298525-hhcfrjrn 50 31 diameter diameter NN cord-298525-hhcfrjrn 50 32 ) ) -RRB- cord-298525-hhcfrjrn 50 33 . . . cord-298525-hhcfrjrn 51 1 Therefore therefore RB cord-298525-hhcfrjrn 51 2 , , , cord-298525-hhcfrjrn 51 3 the the DT cord-298525-hhcfrjrn 51 4 MCA MCA NNP cord-298525-hhcfrjrn 51 5 should should MD cord-298525-hhcfrjrn 51 6 be be VB cord-298525-hhcfrjrn 51 7 normalised normalise VBN cord-298525-hhcfrjrn 51 8 to to IN cord-298525-hhcfrjrn 51 9 baseline baseline JJ cord-298525-hhcfrjrn 51 10 pupil pupil NN cord-298525-hhcfrjrn 51 11 diameter diameter NN cord-298525-hhcfrjrn 51 12 to to TO cord-298525-hhcfrjrn 51 13 account account VB cord-298525-hhcfrjrn 51 14 for for IN cord-298525-hhcfrjrn 51 15 this this DT cord-298525-hhcfrjrn 51 16 effect effect NN cord-298525-hhcfrjrn 51 17 [ [ -LRB- cord-298525-hhcfrjrn 51 18 6 6 CD cord-298525-hhcfrjrn 51 19 ] ] -RRB- cord-298525-hhcfrjrn 51 20 . . . cord-298525-hhcfrjrn 52 1 After after IN cord-298525-hhcfrjrn 52 2 this this DT cord-298525-hhcfrjrn 52 3 peak peak NN cord-298525-hhcfrjrn 52 4 constriction constriction NN cord-298525-hhcfrjrn 52 5 , , , cord-298525-hhcfrjrn 52 6 the the DT cord-298525-hhcfrjrn 52 7 pupil pupil NN cord-298525-hhcfrjrn 52 8 quickly quickly RB cord-298525-hhcfrjrn 52 9 redilates redilate VBZ cord-298525-hhcfrjrn 52 10 or or CC cord-298525-hhcfrjrn 52 11 " " `` cord-298525-hhcfrjrn 52 12 escapes escape VBZ cord-298525-hhcfrjrn 52 13 " " '' cord-298525-hhcfrjrn 52 14 to to IN cord-298525-hhcfrjrn 52 15 a a DT cord-298525-hhcfrjrn 52 16 partially partially RB cord-298525-hhcfrjrn 52 17 constricted constrict VBN cord-298525-hhcfrjrn 52 18 state state NN cord-298525-hhcfrjrn 52 19 during during IN cord-298525-hhcfrjrn 52 20 a a DT cord-298525-hhcfrjrn 52 21 prolonged prolonged JJ cord-298525-hhcfrjrn 52 22 light light JJ cord-298525-hhcfrjrn 52 23 stimulus stimulus NN cord-298525-hhcfrjrn 52 24 lasting last VBG cord-298525-hhcfrjrn 52 25 from from IN cord-298525-hhcfrjrn 52 26 1 1 CD cord-298525-hhcfrjrn 52 27 - - SYM cord-298525-hhcfrjrn 52 28 2 2 CD cord-298525-hhcfrjrn 52 29 up up IN cord-298525-hhcfrjrn 52 30 to to TO cord-298525-hhcfrjrn 52 31 100 100 CD cord-298525-hhcfrjrn 52 32 s s NNPS cord-298525-hhcfrjrn 52 33 , , , cord-298525-hhcfrjrn 52 34 before before IN cord-298525-hhcfrjrn 52 35 slowly slowly RB cord-298525-hhcfrjrn 52 36 redilating redilate VBG cord-298525-hhcfrjrn 52 37 to to IN cord-298525-hhcfrjrn 52 38 the the DT cord-298525-hhcfrjrn 52 39 initial initial JJ cord-298525-hhcfrjrn 52 40 size size NN cord-298525-hhcfrjrn 52 41 [ [ -LRB- cord-298525-hhcfrjrn 52 42 11 11 CD cord-298525-hhcfrjrn 52 43 ] ] -RRB- cord-298525-hhcfrjrn 52 44 . . . cord-298525-hhcfrjrn 53 1 In in IN cord-298525-hhcfrjrn 53 2 addition addition NN cord-298525-hhcfrjrn 53 3 to to IN cord-298525-hhcfrjrn 53 4 the the DT cord-298525-hhcfrjrn 53 5 dynamic dynamic JJ cord-298525-hhcfrjrn 53 6 phases phase NNS cord-298525-hhcfrjrn 53 7 of of IN cord-298525-hhcfrjrn 53 8 the the DT cord-298525-hhcfrjrn 53 9 PLR plr NN cord-298525-hhcfrjrn 53 10 during during IN cord-298525-hhcfrjrn 53 11 light light JJ cord-298525-hhcfrjrn 53 12 stimulation stimulation NN cord-298525-hhcfrjrn 53 13 , , , cord-298525-hhcfrjrn 53 14 there there EX cord-298525-hhcfrjrn 53 15 is be VBZ cord-298525-hhcfrjrn 53 16 also also RB cord-298525-hhcfrjrn 53 17 a a DT cord-298525-hhcfrjrn 53 18 sustained sustained JJ cord-298525-hhcfrjrn 53 19 component component NN cord-298525-hhcfrjrn 53 20 [ [ -LRB- cord-298525-hhcfrjrn 53 21 12 12 CD cord-298525-hhcfrjrn 53 22 , , , cord-298525-hhcfrjrn 53 23 13 13 CD cord-298525-hhcfrjrn 53 24 ] ] -RRB- cord-298525-hhcfrjrn 53 25 . . . cord-298525-hhcfrjrn 54 1 Both both DT cord-298525-hhcfrjrn 54 2 outer outer JJ cord-298525-hhcfrjrn 54 3 and and CC cord-298525-hhcfrjrn 54 4 inner inner JJ cord-298525-hhcfrjrn 54 5 photoreceptors photoreceptor NNS cord-298525-hhcfrjrn 54 6 contribute contribute VBP cord-298525-hhcfrjrn 54 7 to to IN cord-298525-hhcfrjrn 54 8 the the DT cord-298525-hhcfrjrn 54 9 early early JJ cord-298525-hhcfrjrn 54 10 sustained sustained JJ cord-298525-hhcfrjrn 54 11 post post JJ cord-298525-hhcfrjrn 54 12 - - JJ cord-298525-hhcfrjrn 54 13 illumination illumination JJ cord-298525-hhcfrjrn 54 14 pupil pupil NN cord-298525-hhcfrjrn 54 15 response response NN cord-298525-hhcfrjrn 54 16 ( ( -LRB- cord-298525-hhcfrjrn 54 17 PIPR PIPR NNP cord-298525-hhcfrjrn 54 18 ; ; : cord-298525-hhcfrjrn 54 19 < < XX cord-298525-hhcfrjrn 54 20 1.7 1.7 CD cord-298525-hhcfrjrn 54 21 s s POS cord-298525-hhcfrjrn 54 22 post post JJ cord-298525-hhcfrjrn 54 23 - - JJ cord-298525-hhcfrjrn 54 24 stimulus stimulus JJ cord-298525-hhcfrjrn 54 25 ) ) -RRB- cord-298525-hhcfrjrn 54 26 [ [ -LRB- cord-298525-hhcfrjrn 54 27 14 14 CD cord-298525-hhcfrjrn 54 28 ] ] -RRB- cord-298525-hhcfrjrn 54 29 . . . cord-298525-hhcfrjrn 55 1 Subsequently subsequently RB cord-298525-hhcfrjrn 55 2 , , , cord-298525-hhcfrjrn 55 3 the the DT cord-298525-hhcfrjrn 55 4 PIPR PIPR NNP cord-298525-hhcfrjrn 55 5 , , , cord-298525-hhcfrjrn 55 6 which which WDT cord-298525-hhcfrjrn 55 7 may may MD cord-298525-hhcfrjrn 55 8 be be VB cord-298525-hhcfrjrn 55 9 sustained sustain VBN cord-298525-hhcfrjrn 55 10 for for IN cord-298525-hhcfrjrn 55 11 up up IN cord-298525-hhcfrjrn 55 12 to to TO cord-298525-hhcfrjrn 55 13 3 3 CD cord-298525-hhcfrjrn 55 14 minutes minute NNS cord-298525-hhcfrjrn 55 15 after after IN cord-298525-hhcfrjrn 55 16 light light JJ cord-298525-hhcfrjrn 55 17 offset offset NN cord-298525-hhcfrjrn 55 18 depending depend VBG cord-298525-hhcfrjrn 55 19 on on IN cord-298525-hhcfrjrn 55 20 the the DT cord-298525-hhcfrjrn 55 21 properties property NNS cord-298525-hhcfrjrn 55 22 of of IN cord-298525-hhcfrjrn 55 23 the the DT cord-298525-hhcfrjrn 55 24 light light JJ cord-298525-hhcfrjrn 55 25 stimulus stimulus NN cord-298525-hhcfrjrn 55 26 , , , cord-298525-hhcfrjrn 55 27 is be VBZ cord-298525-hhcfrjrn 55 28 solely solely RB cord-298525-hhcfrjrn 55 29 controlled control VBN cord-298525-hhcfrjrn 55 30 by by IN cord-298525-hhcfrjrn 55 31 the the DT cord-298525-hhcfrjrn 55 32 intrinsically intrinsically RB cord-298525-hhcfrjrn 55 33 photosensitive photosensitive JJ cord-298525-hhcfrjrn 55 34 retinal retinal JJ cord-298525-hhcfrjrn 55 35 ganglion ganglion NN cord-298525-hhcfrjrn 55 36 cells cell NNS cord-298525-hhcfrjrn 55 37 that that WDT cord-298525-hhcfrjrn 55 38 depolarise depolarise VBP cord-298525-hhcfrjrn 55 39 during during IN cord-298525-hhcfrjrn 55 40 light light JJ cord-298525-hhcfrjrn 55 41 stimulation stimulation NN cord-298525-hhcfrjrn 55 42 ( ( -LRB- cord-298525-hhcfrjrn 55 43 dependent dependent JJ cord-298525-hhcfrjrn 55 44 on on IN cord-298525-hhcfrjrn 55 45 both both DT cord-298525-hhcfrjrn 55 46 light light JJ cord-298525-hhcfrjrn 55 47 intensity intensity NN cord-298525-hhcfrjrn 55 48 and and CC cord-298525-hhcfrjrn 55 49 wavelength wavelength NN cord-298525-hhcfrjrn 55 50 ) ) -RRB- cord-298525-hhcfrjrn 55 51 and and CC cord-298525-hhcfrjrn 55 52 then then RB cord-298525-hhcfrjrn 55 53 repolarise repolarise VB cord-298525-hhcfrjrn 55 54 slowly slowly RB cord-298525-hhcfrjrn 55 55 after after IN cord-298525-hhcfrjrn 55 56 light light JJ cord-298525-hhcfrjrn 55 57 offset offset NN cord-298525-hhcfrjrn 55 58 [ [ -LRB- cord-298525-hhcfrjrn 55 59 6 6 CD cord-298525-hhcfrjrn 55 60 , , , cord-298525-hhcfrjrn 55 61 [ [ -LRB- cord-298525-hhcfrjrn 55 62 13 13 CD cord-298525-hhcfrjrn 55 63 ] ] -RRB- cord-298525-hhcfrjrn 55 64 [ [ -LRB- cord-298525-hhcfrjrn 55 65 14 14 CD cord-298525-hhcfrjrn 55 66 ] ] -RRB- cord-298525-hhcfrjrn 55 67 [ [ -LRB- cord-298525-hhcfrjrn 55 68 15 15 CD cord-298525-hhcfrjrn 55 69 ] ] -RRB- cord-298525-hhcfrjrn 55 70 . . . cord-298525-hhcfrjrn 56 1 The the DT cord-298525-hhcfrjrn 56 2 response response NN cord-298525-hhcfrjrn 56 3 of of IN cord-298525-hhcfrjrn 56 4 the the DT cord-298525-hhcfrjrn 56 5 pupil pupil NN cord-298525-hhcfrjrn 56 6 to to IN cord-298525-hhcfrjrn 56 7 light light NN cord-298525-hhcfrjrn 56 8 can can MD cord-298525-hhcfrjrn 56 9 be be VB cord-298525-hhcfrjrn 56 10 manually manually RB cord-298525-hhcfrjrn 56 11 assessed assess VBN cord-298525-hhcfrjrn 56 12 using use VBG cord-298525-hhcfrjrn 56 13 the the DT cord-298525-hhcfrjrn 56 14 swinging swinge VBG cord-298525-hhcfrjrn 56 15 flashlight flashlight NN cord-298525-hhcfrjrn 56 16 test test NN cord-298525-hhcfrjrn 56 17 or or CC cord-298525-hhcfrjrn 56 18 using use VBG cord-298525-hhcfrjrn 56 19 a a DT cord-298525-hhcfrjrn 56 20 pupillometer pupillometer JJ cord-298525-hhcfrjrn 56 21 device device NN cord-298525-hhcfrjrn 56 22 . . . cord-298525-hhcfrjrn 57 1 Pupillometers pupillometer NNS cord-298525-hhcfrjrn 57 2 enable enable VBP cord-298525-hhcfrjrn 57 3 objective objective JJ cord-298525-hhcfrjrn 57 4 quantification quantification NN cord-298525-hhcfrjrn 57 5 of of IN cord-298525-hhcfrjrn 57 6 the the DT cord-298525-hhcfrjrn 57 7 PLR plr NN cord-298525-hhcfrjrn 57 8 and and CC cord-298525-hhcfrjrn 57 9 generally generally RB cord-298525-hhcfrjrn 57 10 consist consist VBP cord-298525-hhcfrjrn 57 11 of of IN cord-298525-hhcfrjrn 57 12 an an DT cord-298525-hhcfrjrn 57 13 infrared infrared JJ cord-298525-hhcfrjrn 57 14 - - HYPH cord-298525-hhcfrjrn 57 15 sensitive sensitive JJ cord-298525-hhcfrjrn 57 16 imaging imaging NN cord-298525-hhcfrjrn 57 17 sensor sensor NN cord-298525-hhcfrjrn 57 18 coupled couple VBN cord-298525-hhcfrjrn 57 19 with with IN cord-298525-hhcfrjrn 57 20 a a DT cord-298525-hhcfrjrn 57 21 digital digital JJ cord-298525-hhcfrjrn 57 22 interface interface NN cord-298525-hhcfrjrn 57 23 for for IN cord-298525-hhcfrjrn 57 24 the the DT cord-298525-hhcfrjrn 57 25 automated automate VBN cord-298525-hhcfrjrn 57 26 recording recording NN cord-298525-hhcfrjrn 57 27 , , , cord-298525-hhcfrjrn 57 28 processing processing NN cord-298525-hhcfrjrn 57 29 and and CC cord-298525-hhcfrjrn 57 30 reporting reporting NN cord-298525-hhcfrjrn 57 31 of of IN cord-298525-hhcfrjrn 57 32 pupil pupil NN cord-298525-hhcfrjrn 57 33 data datum NNS cord-298525-hhcfrjrn 57 34 . . . cord-298525-hhcfrjrn 58 1 The the DT cord-298525-hhcfrjrn 58 2 acquired acquire VBN cord-298525-hhcfrjrn 58 3 images image NNS cord-298525-hhcfrjrn 58 4 are be VBP cord-298525-hhcfrjrn 58 5 processed process VBN cord-298525-hhcfrjrn 58 6 to to TO cord-298525-hhcfrjrn 58 7 yield yield VB cord-298525-hhcfrjrn 58 8 a a DT cord-298525-hhcfrjrn 58 9 pupillogram pupillogram NN cord-298525-hhcfrjrn 58 10 with with IN cord-298525-hhcfrjrn 58 11 pupil pupil NN cord-298525-hhcfrjrn 58 12 size size NN cord-298525-hhcfrjrn 58 13 plotted plot VBN cord-298525-hhcfrjrn 58 14 as as IN cord-298525-hhcfrjrn 58 15 a a DT cord-298525-hhcfrjrn 58 16 function function NN cord-298525-hhcfrjrn 58 17 of of IN cord-298525-hhcfrjrn 58 18 time time NN cord-298525-hhcfrjrn 58 19 , , , cord-298525-hhcfrjrn 58 20 from from IN cord-298525-hhcfrjrn 58 21 which which WDT cord-298525-hhcfrjrn 58 22 PLR plr NN cord-298525-hhcfrjrn 58 23 parameters parameter NNS cord-298525-hhcfrjrn 58 24 can can MD cord-298525-hhcfrjrn 58 25 be be VB cord-298525-hhcfrjrn 58 26 calculated calculate VBN cord-298525-hhcfrjrn 58 27 ( ( -LRB- cord-298525-hhcfrjrn 58 28 Figure figure NN cord-298525-hhcfrjrn 58 29 1 1 CD cord-298525-hhcfrjrn 58 30 ) ) -RRB- cord-298525-hhcfrjrn 58 31 . . . cord-298525-hhcfrjrn 59 1 There there EX cord-298525-hhcfrjrn 59 2 are be VBP cord-298525-hhcfrjrn 59 3 several several JJ cord-298525-hhcfrjrn 59 4 commercially commercially RB cord-298525-hhcfrjrn 59 5 available available JJ cord-298525-hhcfrjrn 59 6 pupillometers pupillometer NNS cord-298525-hhcfrjrn 59 7 and and CC cord-298525-hhcfrjrn 59 8 the the DT cord-298525-hhcfrjrn 59 9 relative relative JJ cord-298525-hhcfrjrn 59 10 performance performance NN cord-298525-hhcfrjrn 59 11 of of IN cord-298525-hhcfrjrn 59 12 commercial commercial JJ cord-298525-hhcfrjrn 59 13 systems system NNS cord-298525-hhcfrjrn 59 14 is be VBZ cord-298525-hhcfrjrn 59 15 the the DT cord-298525-hhcfrjrn 59 16 subject subject NN cord-298525-hhcfrjrn 59 17 of of IN cord-298525-hhcfrjrn 59 18 several several JJ cord-298525-hhcfrjrn 59 19 publications publication NNS cord-298525-hhcfrjrn 59 20 [ [ -LRB- cord-298525-hhcfrjrn 59 21 16 16 CD cord-298525-hhcfrjrn 59 22 ] ] -RRB- cord-298525-hhcfrjrn 59 23 [ [ -LRB- cord-298525-hhcfrjrn 59 24 17 17 CD cord-298525-hhcfrjrn 59 25 ] ] -RRB- cord-298525-hhcfrjrn 59 26 [ [ -LRB- cord-298525-hhcfrjrn 59 27 18 18 CD cord-298525-hhcfrjrn 59 28 ] ] -RRB- cord-298525-hhcfrjrn 59 29 . . . cord-298525-hhcfrjrn 60 1 However however RB cord-298525-hhcfrjrn 60 2 , , , cord-298525-hhcfrjrn 60 3 commercial commercial JJ cord-298525-hhcfrjrn 60 4 systems system NNS cord-298525-hhcfrjrn 60 5 are be VBP cord-298525-hhcfrjrn 60 6 typically typically RB cord-298525-hhcfrjrn 60 7 designed design VBN cord-298525-hhcfrjrn 60 8 for for IN cord-298525-hhcfrjrn 60 9 specific specific JJ cord-298525-hhcfrjrn 60 10 applications application NNS cord-298525-hhcfrjrn 60 11 and and CC cord-298525-hhcfrjrn 60 12 use use VB cord-298525-hhcfrjrn 60 13 proprietary proprietary JJ cord-298525-hhcfrjrn 60 14 software software NN cord-298525-hhcfrjrn 60 15 , , , cord-298525-hhcfrjrn 60 16 which which WDT cord-298525-hhcfrjrn 60 17 may may MD cord-298525-hhcfrjrn 60 18 limit limit VB cord-298525-hhcfrjrn 60 19 their -PRON- PRP$ cord-298525-hhcfrjrn 60 20 use use NN cord-298525-hhcfrjrn 60 21 for for IN cord-298525-hhcfrjrn 60 22 basic basic JJ cord-298525-hhcfrjrn 60 23 research research NN cord-298525-hhcfrjrn 60 24 . . . cord-298525-hhcfrjrn 61 1 In in IN cord-298525-hhcfrjrn 61 2 response response NN cord-298525-hhcfrjrn 61 3 , , , cord-298525-hhcfrjrn 61 4 a a DT cord-298525-hhcfrjrn 61 5 number number NN cord-298525-hhcfrjrn 61 6 of of IN cord-298525-hhcfrjrn 61 7 research research NN cord-298525-hhcfrjrn 61 8 groups group NNS cord-298525-hhcfrjrn 61 9 have have VBP cord-298525-hhcfrjrn 61 10 published publish VBN cord-298525-hhcfrjrn 61 11 methods method NNS cord-298525-hhcfrjrn 61 12 for for IN cord-298525-hhcfrjrn 61 13 developing develop VBG cord-298525-hhcfrjrn 61 14 prototype prototype NN cord-298525-hhcfrjrn 61 15 automated automate VBN cord-298525-hhcfrjrn 61 16 infrared infrared JJ cord-298525-hhcfrjrn 61 17 pupillometers pupillometer NNS cord-298525-hhcfrjrn 61 18 , , , cord-298525-hhcfrjrn 61 19 which which WDT cord-298525-hhcfrjrn 61 20 use use VBP cord-298525-hhcfrjrn 61 21 open open JJ cord-298525-hhcfrjrn 61 22 - - HYPH cord-298525-hhcfrjrn 61 23 source source NN cord-298525-hhcfrjrn 61 24 software software NN cord-298525-hhcfrjrn 61 25 [ [ -LRB- cord-298525-hhcfrjrn 61 26 19 19 CD cord-298525-hhcfrjrn 61 27 , , , cord-298525-hhcfrjrn 61 28 20 20 CD cord-298525-hhcfrjrn 61 29 ] ] -RRB- cord-298525-hhcfrjrn 61 30 . . . cord-298525-hhcfrjrn 62 1 There there EX cord-298525-hhcfrjrn 62 2 is be VBZ cord-298525-hhcfrjrn 62 3 also also RB cord-298525-hhcfrjrn 62 4 increasing increase VBG cord-298525-hhcfrjrn 62 5 use use NN cord-298525-hhcfrjrn 62 6 of of IN cord-298525-hhcfrjrn 62 7 remote remote JJ cord-298525-hhcfrjrn 62 8 eye eye NN cord-298525-hhcfrjrn 62 9 - - HYPH cord-298525-hhcfrjrn 62 10 tracking track VBG cord-298525-hhcfrjrn 62 11 devices device NNS cord-298525-hhcfrjrn 62 12 , , , cord-298525-hhcfrjrn 62 13 such such JJ cord-298525-hhcfrjrn 62 14 as as IN cord-298525-hhcfrjrn 62 15 Tobii Tobii NNP cord-298525-hhcfrjrn 62 16 , , , cord-298525-hhcfrjrn 62 17 that that WDT cord-298525-hhcfrjrn 62 18 are be VBP cord-298525-hhcfrjrn 62 19 capable capable JJ cord-298525-hhcfrjrn 62 20 of of IN cord-298525-hhcfrjrn 62 21 measuring measure VBG cord-298525-hhcfrjrn 62 22 pupil pupil NN cord-298525-hhcfrjrn 62 23 size size NN cord-298525-hhcfrjrn 62 24 and and CC cord-298525-hhcfrjrn 62 25 can can MD cord-298525-hhcfrjrn 62 26 be be VB cord-298525-hhcfrjrn 62 27 used use VBN cord-298525-hhcfrjrn 62 28 in in IN cord-298525-hhcfrjrn 62 29 combination combination NN cord-298525-hhcfrjrn 62 30 with with IN cord-298525-hhcfrjrn 62 31 open open JJ cord-298525-hhcfrjrn 62 32 - - HYPH cord-298525-hhcfrjrn 62 33 source source NN cord-298525-hhcfrjrn 62 34 software software NN cord-298525-hhcfrjrn 62 35 for for IN cord-298525-hhcfrjrn 62 36 the the DT cord-298525-hhcfrjrn 62 37 analysis analysis NN cord-298525-hhcfrjrn 62 38 of of IN cord-298525-hhcfrjrn 62 39 PLR PLR NNP cord-298525-hhcfrjrn 62 40 [ [ -LRB- cord-298525-hhcfrjrn 62 41 21 21 CD cord-298525-hhcfrjrn 62 42 ] ] -RRB- cord-298525-hhcfrjrn 62 43 . . . cord-298525-hhcfrjrn 63 1 There there EX cord-298525-hhcfrjrn 63 2 are be VBP cord-298525-hhcfrjrn 63 3 three three CD cord-298525-hhcfrjrn 63 4 major major JJ cord-298525-hhcfrjrn 63 5 divisions division NNS cord-298525-hhcfrjrn 63 6 of of IN cord-298525-hhcfrjrn 63 7 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 63 8 neurons neuron NNS cord-298525-hhcfrjrn 63 9 that that WDT cord-298525-hhcfrjrn 63 10 integrate integrate VBP cord-298525-hhcfrjrn 63 11 the the DT cord-298525-hhcfrjrn 63 12 light light JJ cord-298525-hhcfrjrn 63 13 stimulus stimulus NN cord-298525-hhcfrjrn 63 14 to to TO cord-298525-hhcfrjrn 63 15 produce produce VB cord-298525-hhcfrjrn 63 16 a a DT cord-298525-hhcfrjrn 63 17 pupil pupil NN cord-298525-hhcfrjrn 63 18 contraction contraction NN cord-298525-hhcfrjrn 63 19 : : : cord-298525-hhcfrjrn 63 20 ( ( -LRB- cord-298525-hhcfrjrn 63 21 i i NN cord-298525-hhcfrjrn 63 22 ) ) -RRB- cord-298525-hhcfrjrn 63 23 an an DT cord-298525-hhcfrjrn 63 24 afferent afferent JJ cord-298525-hhcfrjrn 63 25 division division NN cord-298525-hhcfrjrn 63 26 ; ; , cord-298525-hhcfrjrn 63 27 ( ( -LRB- cord-298525-hhcfrjrn 63 28 ii ii NN cord-298525-hhcfrjrn 63 29 ) ) -RRB- cord-298525-hhcfrjrn 63 30 an an DT cord-298525-hhcfrjrn 63 31 interneuron interneuron NNP cord-298525-hhcfrjrn 63 32 division division NN cord-298525-hhcfrjrn 63 33 ; ; : cord-298525-hhcfrjrn 63 34 and and CC cord-298525-hhcfrjrn 63 35 ( ( -LRB- cord-298525-hhcfrjrn 63 36 iii iii NN cord-298525-hhcfrjrn 63 37 ) ) -RRB- cord-298525-hhcfrjrn 63 38 an an DT cord-298525-hhcfrjrn 63 39 efferent efferent JJ cord-298525-hhcfrjrn 63 40 division division NN cord-298525-hhcfrjrn 63 41 . . . cord-298525-hhcfrjrn 64 1 The the DT cord-298525-hhcfrjrn 64 2 response response NN cord-298525-hhcfrjrn 64 3 latency latency NN cord-298525-hhcfrjrn 64 4 , , , cord-298525-hhcfrjrn 64 5 maximum maximum JJ cord-298525-hhcfrjrn 64 6 constriction constriction NN cord-298525-hhcfrjrn 64 7 and and CC cord-298525-hhcfrjrn 64 8 pupil pupil NN cord-298525-hhcfrjrn 64 9 escape escape NN cord-298525-hhcfrjrn 64 10 , , , cord-298525-hhcfrjrn 64 11 and and CC cord-298525-hhcfrjrn 64 12 the the DT cord-298525-hhcfrjrn 64 13 corresponding correspond VBG cord-298525-hhcfrjrn 64 14 constriction constriction NN cord-298525-hhcfrjrn 64 15 parameters parameter NNS cord-298525-hhcfrjrn 64 16 ( ( -LRB- cord-298525-hhcfrjrn 64 17 MCV MCV NNP cord-298525-hhcfrjrn 64 18 , , , cord-298525-hhcfrjrn 64 19 MCA MCA NNP cord-298525-hhcfrjrn 64 20 and and CC cord-298525-hhcfrjrn 64 21 RCA RCA NNP cord-298525-hhcfrjrn 64 22 ; ; , cord-298525-hhcfrjrn 64 23 relative relative JJ cord-298525-hhcfrjrn 64 24 constriction constriction NN cord-298525-hhcfrjrn 64 25 amplitude amplitude NN cord-298525-hhcfrjrn 64 26 ) ) -RRB- cord-298525-hhcfrjrn 64 27 are be VBP cord-298525-hhcfrjrn 64 28 dependent dependent JJ cord-298525-hhcfrjrn 64 29 on on IN cord-298525-hhcfrjrn 64 30 the the DT cord-298525-hhcfrjrn 64 31 actions action NNS cord-298525-hhcfrjrn 64 32 of of IN cord-298525-hhcfrjrn 64 33 the the DT cord-298525-hhcfrjrn 64 34 sphincter sphincter NN cord-298525-hhcfrjrn 64 35 muscle muscle NN cord-298525-hhcfrjrn 64 36 and and CC cord-298525-hhcfrjrn 64 37 on on IN cord-298525-hhcfrjrn 64 38 the the DT cord-298525-hhcfrjrn 64 39 function function NN cord-298525-hhcfrjrn 64 40 of of IN cord-298525-hhcfrjrn 64 41 retinal retinal JJ cord-298525-hhcfrjrn 64 42 photoreceptors photoreceptor NNS cord-298525-hhcfrjrn 64 43 , , , cord-298525-hhcfrjrn 64 44 as as RB cord-298525-hhcfrjrn 64 45 well well RB cord-298525-hhcfrjrn 64 46 as as IN cord-298525-hhcfrjrn 64 47 the the DT cord-298525-hhcfrjrn 64 48 time time NN cord-298525-hhcfrjrn 64 49 consumed consume VBN cord-298525-hhcfrjrn 64 50 in in IN cord-298525-hhcfrjrn 64 51 the the DT cord-298525-hhcfrjrn 64 52 afferent afferent JJ cord-298525-hhcfrjrn 64 53 and and CC cord-298525-hhcfrjrn 64 54 efferent efferent JJ cord-298525-hhcfrjrn 64 55 pathway pathway NN cord-298525-hhcfrjrn 64 56 . . . cord-298525-hhcfrjrn 65 1 They -PRON- PRP cord-298525-hhcfrjrn 65 2 are be VBP cord-298525-hhcfrjrn 65 3 thus thus RB cord-298525-hhcfrjrn 65 4 under under IN cord-298525-hhcfrjrn 65 5 direct direct JJ cord-298525-hhcfrjrn 65 6 control control NN cord-298525-hhcfrjrn 65 7 of of IN cord-298525-hhcfrjrn 65 8 the the DT cord-298525-hhcfrjrn 65 9 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 65 10 nervous nervous JJ cord-298525-hhcfrjrn 65 11 system system NN cord-298525-hhcfrjrn 65 12 . . . cord-298525-hhcfrjrn 66 1 Both both DT cord-298525-hhcfrjrn 66 2 MCV MCV NNP cord-298525-hhcfrjrn 66 3 and and CC cord-298525-hhcfrjrn 66 4 RCA RCA NNP cord-298525-hhcfrjrn 66 5 parameters parameter NNS cord-298525-hhcfrjrn 66 6 are be VBP cord-298525-hhcfrjrn 66 7 dependent dependent JJ cord-298525-hhcfrjrn 66 8 on on IN cord-298525-hhcfrjrn 66 9 the the DT cord-298525-hhcfrjrn 66 10 baseline baseline JJ cord-298525-hhcfrjrn 66 11 pupil pupil NN cord-298525-hhcfrjrn 66 12 diameter diameter NN cord-298525-hhcfrjrn 66 13 in in IN cord-298525-hhcfrjrn 66 14 healthy healthy JJ cord-298525-hhcfrjrn 66 15 individuals individual NNS cord-298525-hhcfrjrn 66 16 and and CC cord-298525-hhcfrjrn 66 17 it -PRON- PRP cord-298525-hhcfrjrn 66 18 is be VBZ cord-298525-hhcfrjrn 66 19 important important JJ cord-298525-hhcfrjrn 66 20 to to TO cord-298525-hhcfrjrn 66 21 normalise normalise VB cord-298525-hhcfrjrn 66 22 measurements measurement NNS cord-298525-hhcfrjrn 66 23 with with IN cord-298525-hhcfrjrn 66 24 respect respect NN cord-298525-hhcfrjrn 66 25 to to IN cord-298525-hhcfrjrn 66 26 baseline baseline JJ cord-298525-hhcfrjrn 66 27 values value NNS cord-298525-hhcfrjrn 66 28 [ [ -LRB- cord-298525-hhcfrjrn 66 29 6 6 CD cord-298525-hhcfrjrn 66 30 , , , cord-298525-hhcfrjrn 66 31 22 22 CD cord-298525-hhcfrjrn 66 32 ] ] -RRB- cord-298525-hhcfrjrn 66 33 . . . cord-298525-hhcfrjrn 67 1 There there EX cord-298525-hhcfrjrn 67 2 is be VBZ cord-298525-hhcfrjrn 67 3 also also RB cord-298525-hhcfrjrn 67 4 a a DT cord-298525-hhcfrjrn 67 5 strong strong JJ cord-298525-hhcfrjrn 67 6 linear linear JJ cord-298525-hhcfrjrn 67 7 relationship relationship NN cord-298525-hhcfrjrn 67 8 between between IN cord-298525-hhcfrjrn 67 9 MCV MCV NNP cord-298525-hhcfrjrn 67 10 and and CC cord-298525-hhcfrjrn 67 11 MCA MCA NNP cord-298525-hhcfrjrn 67 12 [ [ -LRB- cord-298525-hhcfrjrn 67 13 20 20 CD cord-298525-hhcfrjrn 67 14 ] ] -RRB- cord-298525-hhcfrjrn 67 15 ; ; : cord-298525-hhcfrjrn 67 16 thus thus RB cord-298525-hhcfrjrn 67 17 , , , cord-298525-hhcfrjrn 67 18 MCV MCV NNP cord-298525-hhcfrjrn 67 19 and and CC cord-298525-hhcfrjrn 67 20 RCA RCA NNP cord-298525-hhcfrjrn 67 21 are be VBP cord-298525-hhcfrjrn 67 22 considered consider VBN cord-298525-hhcfrjrn 67 23 to to TO cord-298525-hhcfrjrn 67 24 be be VB cord-298525-hhcfrjrn 67 25 the the DT cord-298525-hhcfrjrn 67 26 most most RBS cord-298525-hhcfrjrn 67 27 robust robust JJ cord-298525-hhcfrjrn 67 28 parameters parameter NNS cord-298525-hhcfrjrn 67 29 for for IN cord-298525-hhcfrjrn 67 30 detecting detect VBG cord-298525-hhcfrjrn 67 31 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 67 32 dysfunction dysfunction NN cord-298525-hhcfrjrn 67 33 [ [ -LRB- cord-298525-hhcfrjrn 67 34 23 23 CD cord-298525-hhcfrjrn 67 35 ] ] -RRB- cord-298525-hhcfrjrn 67 36 . . . cord-298525-hhcfrjrn 68 1 The the DT cord-298525-hhcfrjrn 68 2 afferent afferent JJ cord-298525-hhcfrjrn 68 3 limb limb NN cord-298525-hhcfrjrn 68 4 of of IN cord-298525-hhcfrjrn 68 5 the the DT cord-298525-hhcfrjrn 68 6 PLR plr NN cord-298525-hhcfrjrn 68 7 begins begin VBZ cord-298525-hhcfrjrn 68 8 with with IN cord-298525-hhcfrjrn 68 9 photoreceptive photoreceptive JJ cord-298525-hhcfrjrn 68 10 inputs input NNS cord-298525-hhcfrjrn 68 11 from from IN cord-298525-hhcfrjrn 68 12 rod rod NN cord-298525-hhcfrjrn 68 13 , , , cord-298525-hhcfrjrn 68 14 cone cone NN cord-298525-hhcfrjrn 68 15 and and CC cord-298525-hhcfrjrn 68 16 intrinsically intrinsically RB cord-298525-hhcfrjrn 68 17 photosensitive photosensitive JJ cord-298525-hhcfrjrn 68 18 retinal retinal JJ cord-298525-hhcfrjrn 68 19 ganglion ganglion NN cord-298525-hhcfrjrn 68 20 cells cell NNS cord-298525-hhcfrjrn 68 21 ( ( -LRB- cord-298525-hhcfrjrn 68 22 ipRGCs ipRGCs NNP cord-298525-hhcfrjrn 68 23 ) ) -RRB- cord-298525-hhcfrjrn 68 24 located locate VBN cord-298525-hhcfrjrn 68 25 in in IN cord-298525-hhcfrjrn 68 26 the the DT cord-298525-hhcfrjrn 68 27 retina retina NN cord-298525-hhcfrjrn 68 28 ( ( -LRB- cord-298525-hhcfrjrn 68 29 summarised summarise VBN cord-298525-hhcfrjrn 68 30 in in IN cord-298525-hhcfrjrn 68 31 Figure Figure NNP cord-298525-hhcfrjrn 68 32 2 2 CD cord-298525-hhcfrjrn 68 33 ) ) -RRB- cord-298525-hhcfrjrn 68 34 . . . cord-298525-hhcfrjrn 69 1 Under under IN cord-298525-hhcfrjrn 69 2 dark dark JJ cord-298525-hhcfrjrn 69 3 conditions condition NNS cord-298525-hhcfrjrn 69 4 , , , cord-298525-hhcfrjrn 69 5 rod rod NN cord-298525-hhcfrjrn 69 6 and and CC cord-298525-hhcfrjrn 69 7 cone cone NN cord-298525-hhcfrjrn 69 8 photoreceptors photoreceptor NNS cord-298525-hhcfrjrn 69 9 exist exist VBP cord-298525-hhcfrjrn 69 10 in in IN cord-298525-hhcfrjrn 69 11 a a DT cord-298525-hhcfrjrn 69 12 constant constant JJ cord-298525-hhcfrjrn 69 13 depolarised depolarise VBN cord-298525-hhcfrjrn 69 14 state state NN cord-298525-hhcfrjrn 69 15 and and CC cord-298525-hhcfrjrn 69 16 continuously continuously RB cord-298525-hhcfrjrn 69 17 release release VB cord-298525-hhcfrjrn 69 18 glutamate glutamate NN cord-298525-hhcfrjrn 69 19 [ [ -LRB- cord-298525-hhcfrjrn 69 20 24 24 CD cord-298525-hhcfrjrn 69 21 , , , cord-298525-hhcfrjrn 69 22 25 25 CD cord-298525-hhcfrjrn 69 23 ] ] -RRB- cord-298525-hhcfrjrn 69 24 . . . cord-298525-hhcfrjrn 70 1 However however RB cord-298525-hhcfrjrn 70 2 , , , cord-298525-hhcfrjrn 70 3 when when WRB cord-298525-hhcfrjrn 70 4 stimulated stimulate VBN cord-298525-hhcfrjrn 70 5 by by IN cord-298525-hhcfrjrn 70 6 light light NN cord-298525-hhcfrjrn 70 7 , , , cord-298525-hhcfrjrn 70 8 the the DT cord-298525-hhcfrjrn 70 9 rod rod NN cord-298525-hhcfrjrn 70 10 and and CC cord-298525-hhcfrjrn 70 11 cone cone NN cord-298525-hhcfrjrn 70 12 photoreceptors photoreceptor NNS cord-298525-hhcfrjrn 70 13 undergo undergo VBP cord-298525-hhcfrjrn 70 14 graded grade VBN cord-298525-hhcfrjrn 70 15 alterations alteration NNS cord-298525-hhcfrjrn 70 16 in in IN cord-298525-hhcfrjrn 70 17 membrane membrane NN cord-298525-hhcfrjrn 70 18 potential potential NN cord-298525-hhcfrjrn 70 19 and and CC cord-298525-hhcfrjrn 70 20 hyperpolarize hyperpolarize NNP cord-298525-hhcfrjrn 70 21 , , , cord-298525-hhcfrjrn 70 22 resulting result VBG cord-298525-hhcfrjrn 70 23 in in IN cord-298525-hhcfrjrn 70 24 a a DT cord-298525-hhcfrjrn 70 25 reduction reduction NN cord-298525-hhcfrjrn 70 26 in in IN cord-298525-hhcfrjrn 70 27 glutamate glutamate NN cord-298525-hhcfrjrn 70 28 release release NN cord-298525-hhcfrjrn 70 29 . . . cord-298525-hhcfrjrn 71 1 Rod rod NN cord-298525-hhcfrjrn 71 2 and and CC cord-298525-hhcfrjrn 71 3 cone cone NN cord-298525-hhcfrjrn 71 4 cells cell NNS cord-298525-hhcfrjrn 71 5 synapse synapse NN cord-298525-hhcfrjrn 71 6 with with IN cord-298525-hhcfrjrn 71 7 their -PRON- PRP$ cord-298525-hhcfrjrn 71 8 respective respective JJ cord-298525-hhcfrjrn 71 9 bipolar bipolar JJ cord-298525-hhcfrjrn 71 10 cells cell NNS cord-298525-hhcfrjrn 71 11 and and CC cord-298525-hhcfrjrn 71 12 reductions reduction NNS cord-298525-hhcfrjrn 71 13 in in IN cord-298525-hhcfrjrn 71 14 glutamate glutamate NN cord-298525-hhcfrjrn 71 15 release release NN cord-298525-hhcfrjrn 71 16 results result NNS cord-298525-hhcfrjrn 71 17 in in IN cord-298525-hhcfrjrn 71 18 either either DT cord-298525-hhcfrjrn 71 19 inhibition inhibition NN cord-298525-hhcfrjrn 71 20 or or CC cord-298525-hhcfrjrn 71 21 disinhibition disinhibition NN cord-298525-hhcfrjrn 71 22 of of IN cord-298525-hhcfrjrn 71 23 the the DT cord-298525-hhcfrjrn 71 24 bipolar bipolar JJ cord-298525-hhcfrjrn 71 25 cells cell NNS cord-298525-hhcfrjrn 71 26 depending depend VBG cord-298525-hhcfrjrn 71 27 on on IN cord-298525-hhcfrjrn 71 28 whether whether IN cord-298525-hhcfrjrn 71 29 they -PRON- PRP cord-298525-hhcfrjrn 71 30 express express VBP cord-298525-hhcfrjrn 71 31 excitatory excitatory JJ cord-298525-hhcfrjrn 71 32 ionotropic ionotropic NNS cord-298525-hhcfrjrn 71 33 ( ( -LRB- cord-298525-hhcfrjrn 71 34 " " `` cord-298525-hhcfrjrn 71 35 ON ON NNP cord-298525-hhcfrjrn 71 36 " " '' cord-298525-hhcfrjrn 71 37 ) ) -RRB- cord-298525-hhcfrjrn 71 38 or or CC cord-298525-hhcfrjrn 71 39 inhibitory inhibitory JJ cord-298525-hhcfrjrn 71 40 metabotropic metabotropic NNS cord-298525-hhcfrjrn 71 41 ( ( -LRB- cord-298525-hhcfrjrn 71 42 " " `` cord-298525-hhcfrjrn 71 43 OFF off JJ cord-298525-hhcfrjrn 71 44 " " '' cord-298525-hhcfrjrn 71 45 ) ) -RRB- cord-298525-hhcfrjrn 71 46 glutamate glutamate NN cord-298525-hhcfrjrn 71 47 receptors receptor NNS cord-298525-hhcfrjrn 71 48 [ [ -LRB- cord-298525-hhcfrjrn 71 49 26 26 CD cord-298525-hhcfrjrn 71 50 ] ] -RRB- cord-298525-hhcfrjrn 71 51 . . . cord-298525-hhcfrjrn 72 1 These these DT cord-298525-hhcfrjrn 72 2 " " `` cord-298525-hhcfrjrn 72 3 ON ON NNP cord-298525-hhcfrjrn 72 4 " " '' cord-298525-hhcfrjrn 72 5 or or CC cord-298525-hhcfrjrn 72 6 " " `` cord-298525-hhcfrjrn 72 7 OFF off JJ cord-298525-hhcfrjrn 72 8 " " '' cord-298525-hhcfrjrn 72 9 bipolar bipolar JJ cord-298525-hhcfrjrn 72 10 cell cell NN cord-298525-hhcfrjrn 72 11 subtypes subtype NNS cord-298525-hhcfrjrn 72 12 synapse synapse NN cord-298525-hhcfrjrn 72 13 with with IN cord-298525-hhcfrjrn 72 14 the the DT cord-298525-hhcfrjrn 72 15 corresponding corresponding JJ cord-298525-hhcfrjrn 72 16 retinal retinal JJ cord-298525-hhcfrjrn 72 17 ganglion ganglion NN cord-298525-hhcfrjrn 72 18 cell cell NN cord-298525-hhcfrjrn 72 19 ( ( -LRB- cord-298525-hhcfrjrn 72 20 RGC RGC NNP cord-298525-hhcfrjrn 72 21 ) ) -RRB- cord-298525-hhcfrjrn 72 22 in in IN cord-298525-hhcfrjrn 72 23 the the DT cord-298525-hhcfrjrn 72 24 non non JJ cord-298525-hhcfrjrn 72 25 - - JJ cord-298525-hhcfrjrn 72 26 cholinergic cholinergic JJ cord-298525-hhcfrjrn 72 27 regions region NNS cord-298525-hhcfrjrn 72 28 of of IN cord-298525-hhcfrjrn 72 29 the the DT cord-298525-hhcfrjrn 72 30 inner inner JJ cord-298525-hhcfrjrn 72 31 plexiform plexiform NNS cord-298525-hhcfrjrn 72 32 layer layer NN cord-298525-hhcfrjrn 72 33 ( ( -LRB- cord-298525-hhcfrjrn 72 34 IPL IPL NNP cord-298525-hhcfrjrn 72 35 ) ) -RRB- cord-298525-hhcfrjrn 72 36 . . . cord-298525-hhcfrjrn 73 1 Horizontal horizontal JJ cord-298525-hhcfrjrn 73 2 neurotransmission neurotransmission NN cord-298525-hhcfrjrn 73 3 also also RB cord-298525-hhcfrjrn 73 4 occurs occur VBZ cord-298525-hhcfrjrn 73 5 within within IN cord-298525-hhcfrjrn 73 6 the the DT cord-298525-hhcfrjrn 73 7 IPL IPL NNP cord-298525-hhcfrjrn 73 8 and and CC cord-298525-hhcfrjrn 73 9 outer outer JJ cord-298525-hhcfrjrn 73 10 plexiform plexiform NNS cord-298525-hhcfrjrn 73 11 layer layer NN cord-298525-hhcfrjrn 73 12 ( ( -LRB- cord-298525-hhcfrjrn 73 13 OPL OPL NNP cord-298525-hhcfrjrn 73 14 ) ) -RRB- cord-298525-hhcfrjrn 73 15 via via IN cord-298525-hhcfrjrn 73 16 amacrine amacrine JJ cord-298525-hhcfrjrn 73 17 and and CC cord-298525-hhcfrjrn 73 18 horizontal horizontal JJ cord-298525-hhcfrjrn 73 19 cells cell NNS cord-298525-hhcfrjrn 73 20 , , , cord-298525-hhcfrjrn 73 21 respectively respectively RB cord-298525-hhcfrjrn 73 22 , , , cord-298525-hhcfrjrn 73 23 and and CC cord-298525-hhcfrjrn 73 24 is be VBZ cord-298525-hhcfrjrn 73 25 critical critical JJ cord-298525-hhcfrjrn 73 26 in in IN cord-298525-hhcfrjrn 73 27 shaping shape VBG cord-298525-hhcfrjrn 73 28 the the DT cord-298525-hhcfrjrn 73 29 spatial spatial JJ cord-298525-hhcfrjrn 73 30 and and CC cord-298525-hhcfrjrn 73 31 temporal temporal JJ cord-298525-hhcfrjrn 73 32 aspects aspect NNS cord-298525-hhcfrjrn 73 33 of of IN cord-298525-hhcfrjrn 73 34 photopic photopic NNP cord-298525-hhcfrjrn 73 35 and and CC cord-298525-hhcfrjrn 73 36 scotopic scotopic NNP cord-298525-hhcfrjrn 73 37 vision vision NNP cord-298525-hhcfrjrn 73 38 [ [ -LRB- cord-298525-hhcfrjrn 73 39 27 27 CD cord-298525-hhcfrjrn 73 40 ] ] -RRB- cord-298525-hhcfrjrn 73 41 . . . cord-298525-hhcfrjrn 74 1 The the DT cord-298525-hhcfrjrn 74 2 third third JJ cord-298525-hhcfrjrn 74 3 photoreceptor photoreceptor NN cord-298525-hhcfrjrn 74 4 , , , cord-298525-hhcfrjrn 74 5 ipRGC iprgc FW cord-298525-hhcfrjrn 74 6 , , , cord-298525-hhcfrjrn 74 7 accounts account VBZ cord-298525-hhcfrjrn 74 8 for for IN cord-298525-hhcfrjrn 74 9 approximately approximately RB cord-298525-hhcfrjrn 74 10 1 1 CD cord-298525-hhcfrjrn 74 11 % % NN cord-298525-hhcfrjrn 74 12 of of IN cord-298525-hhcfrjrn 74 13 the the DT cord-298525-hhcfrjrn 74 14 total total JJ cord-298525-hhcfrjrn 74 15 RGCs rgc NNS cord-298525-hhcfrjrn 74 16 [ [ -LRB- cord-298525-hhcfrjrn 74 17 28 28 CD cord-298525-hhcfrjrn 74 18 ] ] -RRB- cord-298525-hhcfrjrn 75 1 [ [ -LRB- cord-298525-hhcfrjrn 75 2 29 29 CD cord-298525-hhcfrjrn 75 3 ] ] -RRB- cord-298525-hhcfrjrn 75 4 [ [ -LRB- cord-298525-hhcfrjrn 75 5 30 30 CD cord-298525-hhcfrjrn 75 6 ] ] -RRB- cord-298525-hhcfrjrn 75 7 . . . cord-298525-hhcfrjrn 76 1 These these DT cord-298525-hhcfrjrn 76 2 cells cell NNS cord-298525-hhcfrjrn 76 3 have have VBP cord-298525-hhcfrjrn 76 4 a a DT cord-298525-hhcfrjrn 76 5 role role NN cord-298525-hhcfrjrn 76 6 in in IN cord-298525-hhcfrjrn 76 7 non non JJ cord-298525-hhcfrjrn 76 8 - - JJ cord-298525-hhcfrjrn 76 9 image image NN cord-298525-hhcfrjrn 76 10 - - HYPH cord-298525-hhcfrjrn 76 11 forming form VBG cord-298525-hhcfrjrn 76 12 visual visual JJ cord-298525-hhcfrjrn 76 13 processes process NNS cord-298525-hhcfrjrn 76 14 , , , cord-298525-hhcfrjrn 76 15 such such JJ cord-298525-hhcfrjrn 76 16 as as IN cord-298525-hhcfrjrn 76 17 circadian circadian NN cord-298525-hhcfrjrn 76 18 photoentrainment photoentrainment NN cord-298525-hhcfrjrn 76 19 , , , cord-298525-hhcfrjrn 76 20 as as RB cord-298525-hhcfrjrn 76 21 well well RB cord-298525-hhcfrjrn 76 22 as as IN cord-298525-hhcfrjrn 76 23 in in IN cord-298525-hhcfrjrn 76 24 the the DT cord-298525-hhcfrjrn 76 25 PLR PLR NNP cord-298525-hhcfrjrn 76 26 [ [ -LRB- cord-298525-hhcfrjrn 76 27 31 31 CD cord-298525-hhcfrjrn 76 28 ] ] -RRB- cord-298525-hhcfrjrn 76 29 [ [ -LRB- cord-298525-hhcfrjrn 76 30 32 32 CD cord-298525-hhcfrjrn 76 31 ] ] -RRB- cord-298525-hhcfrjrn 76 32 [ [ -LRB- cord-298525-hhcfrjrn 76 33 33 33 CD cord-298525-hhcfrjrn 76 34 ] ] -RRB- cord-298525-hhcfrjrn 76 35 . . . cord-298525-hhcfrjrn 77 1 The the DT cord-298525-hhcfrjrn 77 2 ipRGCs iprgcs JJ cord-298525-hhcfrjrn 77 3 regulate regulate VBP cord-298525-hhcfrjrn 77 4 pupil pupil NN cord-298525-hhcfrjrn 77 5 size size NN cord-298525-hhcfrjrn 77 6 through through IN cord-298525-hhcfrjrn 77 7 the the DT cord-298525-hhcfrjrn 77 8 integration integration NN cord-298525-hhcfrjrn 77 9 of of IN cord-298525-hhcfrjrn 77 10 extrinsic extrinsic JJ cord-298525-hhcfrjrn 77 11 signals signal NNS cord-298525-hhcfrjrn 77 12 from from IN cord-298525-hhcfrjrn 77 13 rods rod NNS cord-298525-hhcfrjrn 77 14 and and CC cord-298525-hhcfrjrn 77 15 cones cone NNS cord-298525-hhcfrjrn 77 16 but but CC cord-298525-hhcfrjrn 77 17 also also RB cord-298525-hhcfrjrn 77 18 through through IN cord-298525-hhcfrjrn 77 19 intrinsic intrinsic JJ cord-298525-hhcfrjrn 77 20 ( ( -LRB- cord-298525-hhcfrjrn 77 21 melanopsin melanopsin NNP cord-298525-hhcfrjrn 77 22 ) ) -RRB- cord-298525-hhcfrjrn 77 23 phototransduction phototransduction NN cord-298525-hhcfrjrn 77 24 [ [ -LRB- cord-298525-hhcfrjrn 77 25 12 12 CD cord-298525-hhcfrjrn 77 26 ] ] -RRB- cord-298525-hhcfrjrn 77 27 . . . cord-298525-hhcfrjrn 78 1 Melanopsin Melanopsin NNP cord-298525-hhcfrjrn 78 2 is be VBZ cord-298525-hhcfrjrn 78 3 a a DT cord-298525-hhcfrjrn 78 4 G g NN cord-298525-hhcfrjrn 78 5 protein protein NN cord-298525-hhcfrjrn 78 6 - - HYPH cord-298525-hhcfrjrn 78 7 coupled couple VBN cord-298525-hhcfrjrn 78 8 photopigment photopigment NN cord-298525-hhcfrjrn 78 9 , , , cord-298525-hhcfrjrn 78 10 which which WDT cord-298525-hhcfrjrn 78 11 is be VBZ cord-298525-hhcfrjrn 78 12 maximally maximally RB cord-298525-hhcfrjrn 78 13 sensitive sensitive JJ cord-298525-hhcfrjrn 78 14 to to IN cord-298525-hhcfrjrn 78 15 482 482 CD cord-298525-hhcfrjrn 78 16 nm nm NN cord-298525-hhcfrjrn 78 17 wavelength wavelength NN cord-298525-hhcfrjrn 78 18 light light NN cord-298525-hhcfrjrn 78 19 and and CC cord-298525-hhcfrjrn 78 20 , , , cord-298525-hhcfrjrn 78 21 unlike unlike IN cord-298525-hhcfrjrn 78 22 rods rod NNS cord-298525-hhcfrjrn 78 23 and and CC cord-298525-hhcfrjrn 78 24 cones cone NNS cord-298525-hhcfrjrn 78 25 , , , cord-298525-hhcfrjrn 78 26 depolarizes depolarize VBZ cord-298525-hhcfrjrn 78 27 in in IN cord-298525-hhcfrjrn 78 28 response response NN cord-298525-hhcfrjrn 78 29 to to IN cord-298525-hhcfrjrn 78 30 light light JJ cord-298525-hhcfrjrn 78 31 following follow VBG cord-298525-hhcfrjrn 78 32 activation activation NN cord-298525-hhcfrjrn 78 33 of of IN cord-298525-hhcfrjrn 78 34 a a DT cord-298525-hhcfrjrn 78 35 phototransduction phototransduction NN cord-298525-hhcfrjrn 78 36 cascade cascade NN cord-298525-hhcfrjrn 78 37 involving involve VBG cord-298525-hhcfrjrn 78 38 Gq/11 Gq/11 NNS cord-298525-hhcfrjrn 78 39 and and CC cord-298525-hhcfrjrn 78 40 phospholipase phospholipase NN cord-298525-hhcfrjrn 78 41 C C NNP cord-298525-hhcfrjrn 78 42 [ [ -LRB- cord-298525-hhcfrjrn 78 43 34 34 CD cord-298525-hhcfrjrn 78 44 - - SYM cord-298525-hhcfrjrn 78 45 37 37 CD cord-298525-hhcfrjrn 78 46 ] ] -RRB- cord-298525-hhcfrjrn 78 47 . . . cord-298525-hhcfrjrn 79 1 Unlike unlike IN cord-298525-hhcfrjrn 79 2 rods rod NNS cord-298525-hhcfrjrn 79 3 and and CC cord-298525-hhcfrjrn 79 4 cones cone NNS cord-298525-hhcfrjrn 79 5 , , , cord-298525-hhcfrjrn 79 6 which which WDT cord-298525-hhcfrjrn 79 7 have have VBP cord-298525-hhcfrjrn 79 8 their -PRON- PRP$ cord-298525-hhcfrjrn 79 9 photopigment photopigment NN cord-298525-hhcfrjrn 79 10 concentrated concentrate VBN cord-298525-hhcfrjrn 79 11 in in IN cord-298525-hhcfrjrn 79 12 specialised specialised JJ cord-298525-hhcfrjrn 79 13 light light NN cord-298525-hhcfrjrn 79 14 - - HYPH cord-298525-hhcfrjrn 79 15 absorbing absorb VBG cord-298525-hhcfrjrn 79 16 cellular cellular JJ cord-298525-hhcfrjrn 79 17 domains domain NNS cord-298525-hhcfrjrn 79 18 ( ( -LRB- cord-298525-hhcfrjrn 79 19 outer outer JJ cord-298525-hhcfrjrn 79 20 segment segment NN cord-298525-hhcfrjrn 79 21 ) ) -RRB- cord-298525-hhcfrjrn 79 22 , , , cord-298525-hhcfrjrn 79 23 melanopsin melanopsin NNP cord-298525-hhcfrjrn 79 24 is be VBZ cord-298525-hhcfrjrn 79 25 distributed distribute VBN cord-298525-hhcfrjrn 79 26 throughout throughout IN cord-298525-hhcfrjrn 79 27 the the DT cord-298525-hhcfrjrn 79 28 plasma plasma NN cord-298525-hhcfrjrn 79 29 membrane membrane NN cord-298525-hhcfrjrn 79 30 of of IN cord-298525-hhcfrjrn 79 31 ipRGCs iprgcs JJ cord-298525-hhcfrjrn 79 32 [ [ -LRB- cord-298525-hhcfrjrn 79 33 28 28 CD cord-298525-hhcfrjrn 79 34 ] ] -RRB- cord-298525-hhcfrjrn 79 35 . . . cord-298525-hhcfrjrn 80 1 The the DT cord-298525-hhcfrjrn 80 2 ipRGCs iprgc NNS cord-298525-hhcfrjrn 80 3 also also RB cord-298525-hhcfrjrn 80 4 directly directly RB cord-298525-hhcfrjrn 80 5 contribute contribute VB cord-298525-hhcfrjrn 80 6 to to IN cord-298525-hhcfrjrn 80 7 the the DT cord-298525-hhcfrjrn 80 8 PIPR PIPR NNP cord-298525-hhcfrjrn 80 9 as as IN cord-298525-hhcfrjrn 80 10 a a DT cord-298525-hhcfrjrn 80 11 sustained sustained JJ cord-298525-hhcfrjrn 80 12 constriction constriction NN cord-298525-hhcfrjrn 80 13 of of IN cord-298525-hhcfrjrn 80 14 the the DT cord-298525-hhcfrjrn 80 15 PLR plr NN cord-298525-hhcfrjrn 80 16 ( ( -LRB- cord-298525-hhcfrjrn 80 17 > > NFP cord-298525-hhcfrjrn 80 18 30 30 CD cord-298525-hhcfrjrn 80 19 s s NNPS cord-298525-hhcfrjrn 80 20 ) ) -RRB- cord-298525-hhcfrjrn 80 21 in in IN cord-298525-hhcfrjrn 80 22 response response NN cord-298525-hhcfrjrn 80 23 to to IN cord-298525-hhcfrjrn 80 24 high high JJ cord-298525-hhcfrjrn 80 25 intensity intensity NN cord-298525-hhcfrjrn 80 26 , , , cord-298525-hhcfrjrn 80 27 short short JJ cord-298525-hhcfrjrn 80 28 wavelength wavelength NN cord-298525-hhcfrjrn 80 29 light light NN cord-298525-hhcfrjrn 80 30 [ [ -LRB- cord-298525-hhcfrjrn 80 31 14 14 CD cord-298525-hhcfrjrn 80 32 , , , cord-298525-hhcfrjrn 80 33 15 15 CD cord-298525-hhcfrjrn 80 34 , , , cord-298525-hhcfrjrn 80 35 28 28 CD cord-298525-hhcfrjrn 80 36 , , , cord-298525-hhcfrjrn 80 37 [ [ -LRB- cord-298525-hhcfrjrn 80 38 38 38 CD cord-298525-hhcfrjrn 80 39 ] ] -RRB- cord-298525-hhcfrjrn 80 40 [ [ -LRB- cord-298525-hhcfrjrn 80 41 39 39 CD cord-298525-hhcfrjrn 80 42 ] ] -RRB- cord-298525-hhcfrjrn 80 43 [ [ -LRB- cord-298525-hhcfrjrn 80 44 40 40 CD cord-298525-hhcfrjrn 80 45 ] ] -RRB- cord-298525-hhcfrjrn 80 46 . . . cord-298525-hhcfrjrn 81 1 protein protein NN cord-298525-hhcfrjrn 81 2 - - HYPH cord-298525-hhcfrjrn 81 3 coupled couple VBN cord-298525-hhcfrjrn 81 4 photopigment photopigment NN cord-298525-hhcfrjrn 81 5 , , , cord-298525-hhcfrjrn 81 6 which which WDT cord-298525-hhcfrjrn 81 7 is be VBZ cord-298525-hhcfrjrn 81 8 maximally maximally RB cord-298525-hhcfrjrn 81 9 sensitive sensitive JJ cord-298525-hhcfrjrn 81 10 to to IN cord-298525-hhcfrjrn 81 11 482 482 CD cord-298525-hhcfrjrn 81 12 nm nm NN cord-298525-hhcfrjrn 81 13 wavelength wavelength NN cord-298525-hhcfrjrn 81 14 light light NN cord-298525-hhcfrjrn 81 15 and and CC cord-298525-hhcfrjrn 81 16 , , , cord-298525-hhcfrjrn 81 17 unlike unlike IN cord-298525-hhcfrjrn 81 18 rods rod NNS cord-298525-hhcfrjrn 81 19 and and CC cord-298525-hhcfrjrn 81 20 cones cone NNS cord-298525-hhcfrjrn 81 21 , , , cord-298525-hhcfrjrn 81 22 depolarizes depolarize VBZ cord-298525-hhcfrjrn 81 23 in in IN cord-298525-hhcfrjrn 81 24 response response NN cord-298525-hhcfrjrn 81 25 to to IN cord-298525-hhcfrjrn 81 26 light light JJ cord-298525-hhcfrjrn 81 27 following follow VBG cord-298525-hhcfrjrn 81 28 activation activation NN cord-298525-hhcfrjrn 81 29 of of IN cord-298525-hhcfrjrn 81 30 a a DT cord-298525-hhcfrjrn 81 31 phototransduction phototransduction NN cord-298525-hhcfrjrn 81 32 cascade cascade NN cord-298525-hhcfrjrn 81 33 involving involve VBG cord-298525-hhcfrjrn 81 34 Gq/11 Gq/11 NNS cord-298525-hhcfrjrn 81 35 and and CC cord-298525-hhcfrjrn 81 36 phospholipase phospholipase NN cord-298525-hhcfrjrn 81 37 C C NNP cord-298525-hhcfrjrn 81 38 [ [ -LRB- cord-298525-hhcfrjrn 81 39 34 34 CD cord-298525-hhcfrjrn 81 40 - - SYM cord-298525-hhcfrjrn 81 41 37 37 CD cord-298525-hhcfrjrn 81 42 ] ] -RRB- cord-298525-hhcfrjrn 81 43 . . . cord-298525-hhcfrjrn 82 1 Unlike unlike IN cord-298525-hhcfrjrn 82 2 rods rod NNS cord-298525-hhcfrjrn 82 3 and and CC cord-298525-hhcfrjrn 82 4 cones cone NNS cord-298525-hhcfrjrn 82 5 , , , cord-298525-hhcfrjrn 82 6 which which WDT cord-298525-hhcfrjrn 82 7 have have VBP cord-298525-hhcfrjrn 82 8 their -PRON- PRP$ cord-298525-hhcfrjrn 82 9 photopigment photopigment NN cord-298525-hhcfrjrn 82 10 concentrated concentrate VBN cord-298525-hhcfrjrn 82 11 in in IN cord-298525-hhcfrjrn 82 12 specialised specialised JJ cord-298525-hhcfrjrn 82 13 light light NN cord-298525-hhcfrjrn 82 14 - - HYPH cord-298525-hhcfrjrn 82 15 absorbing absorb VBG cord-298525-hhcfrjrn 82 16 cellular cellular JJ cord-298525-hhcfrjrn 82 17 domains domain NNS cord-298525-hhcfrjrn 82 18 ( ( -LRB- cord-298525-hhcfrjrn 82 19 outer outer JJ cord-298525-hhcfrjrn 82 20 segment segment NN cord-298525-hhcfrjrn 82 21 ) ) -RRB- cord-298525-hhcfrjrn 82 22 , , , cord-298525-hhcfrjrn 82 23 melanopsin melanopsin NNP cord-298525-hhcfrjrn 82 24 is be VBZ cord-298525-hhcfrjrn 82 25 distributed distribute VBN cord-298525-hhcfrjrn 82 26 throughout throughout IN cord-298525-hhcfrjrn 82 27 the the DT cord-298525-hhcfrjrn 82 28 plasma plasma NN cord-298525-hhcfrjrn 82 29 membrane membrane NN cord-298525-hhcfrjrn 82 30 of of IN cord-298525-hhcfrjrn 82 31 ipRGCs iprgcs JJ cord-298525-hhcfrjrn 82 32 [ [ -LRB- cord-298525-hhcfrjrn 82 33 28 28 CD cord-298525-hhcfrjrn 82 34 ] ] -RRB- cord-298525-hhcfrjrn 82 35 . . . cord-298525-hhcfrjrn 83 1 The the DT cord-298525-hhcfrjrn 83 2 ipRGCs iprgc NNS cord-298525-hhcfrjrn 83 3 also also RB cord-298525-hhcfrjrn 83 4 directly directly RB cord-298525-hhcfrjrn 83 5 contribute contribute VB cord-298525-hhcfrjrn 83 6 to to IN cord-298525-hhcfrjrn 83 7 the the DT cord-298525-hhcfrjrn 83 8 PIPR PIPR NNP cord-298525-hhcfrjrn 83 9 as as IN cord-298525-hhcfrjrn 83 10 a a DT cord-298525-hhcfrjrn 83 11 sustained sustained JJ cord-298525-hhcfrjrn 83 12 constriction constriction NN cord-298525-hhcfrjrn 83 13 of of IN cord-298525-hhcfrjrn 83 14 the the DT cord-298525-hhcfrjrn 83 15 PLR plr NN cord-298525-hhcfrjrn 83 16 ( ( -LRB- cord-298525-hhcfrjrn 83 17 > > NFP cord-298525-hhcfrjrn 83 18 30 30 CD cord-298525-hhcfrjrn 83 19 s s NNPS cord-298525-hhcfrjrn 83 20 ) ) -RRB- cord-298525-hhcfrjrn 83 21 in in IN cord-298525-hhcfrjrn 83 22 response response NN cord-298525-hhcfrjrn 83 23 to to IN cord-298525-hhcfrjrn 83 24 high high JJ cord-298525-hhcfrjrn 83 25 intensity intensity NN cord-298525-hhcfrjrn 83 26 , , , cord-298525-hhcfrjrn 83 27 short short JJ cord-298525-hhcfrjrn 83 28 wavelength wavelength NN cord-298525-hhcfrjrn 83 29 light light NN cord-298525-hhcfrjrn 83 30 [ [ -LRB- cord-298525-hhcfrjrn 83 31 14 14 CD cord-298525-hhcfrjrn 83 32 , , , cord-298525-hhcfrjrn 83 33 15 15 CD cord-298525-hhcfrjrn 83 34 , , , cord-298525-hhcfrjrn 83 35 28 28 CD cord-298525-hhcfrjrn 83 36 , , , cord-298525-hhcfrjrn 83 37 [ [ -LRB- cord-298525-hhcfrjrn 83 38 38 38 CD cord-298525-hhcfrjrn 83 39 ] ] -RRB- cord-298525-hhcfrjrn 83 40 [ [ -LRB- cord-298525-hhcfrjrn 83 41 39 39 CD cord-298525-hhcfrjrn 83 42 ] ] -RRB- cord-298525-hhcfrjrn 83 43 [ [ -LRB- cord-298525-hhcfrjrn 83 44 40 40 CD cord-298525-hhcfrjrn 83 45 ] ] -RRB- cord-298525-hhcfrjrn 83 46 . . . cord-298525-hhcfrjrn 84 1 The the DT cord-298525-hhcfrjrn 84 2 axon axon NN cord-298525-hhcfrjrn 84 3 terminals terminal NNS cord-298525-hhcfrjrn 84 4 of of IN cord-298525-hhcfrjrn 84 5 the the DT cord-298525-hhcfrjrn 84 6 bipolar bipolar JJ cord-298525-hhcfrjrn 84 7 cells cell NNS cord-298525-hhcfrjrn 84 8 stratify stratify VBP cord-298525-hhcfrjrn 84 9 at at IN cord-298525-hhcfrjrn 84 10 different different JJ cord-298525-hhcfrjrn 84 11 depths depth NNS cord-298525-hhcfrjrn 84 12 of of IN cord-298525-hhcfrjrn 84 13 the the DT cord-298525-hhcfrjrn 84 14 inner inner JJ cord-298525-hhcfrjrn 84 15 plexiform plexiform NNS cord-298525-hhcfrjrn 84 16 layer layer NN cord-298525-hhcfrjrn 84 17 , , , cord-298525-hhcfrjrn 84 18 which which WDT cord-298525-hhcfrjrn 84 19 is be VBZ cord-298525-hhcfrjrn 84 20 subdivided subdivide VBN cord-298525-hhcfrjrn 84 21 into into IN cord-298525-hhcfrjrn 84 22 the the DT cord-298525-hhcfrjrn 84 23 OFF off JJ cord-298525-hhcfrjrn 84 24 outer outer JJ cord-298525-hhcfrjrn 84 25 sublamina sublamina NN cord-298525-hhcfrjrn 84 26 ( ( -LRB- cord-298525-hhcfrjrn 84 27 where where WRB cord-298525-hhcfrjrn 84 28 OFF off RB cord-298525-hhcfrjrn 84 29 bipolar bipolar JJ cord-298525-hhcfrjrn 84 30 cells cell NNS cord-298525-hhcfrjrn 84 31 terminate terminate VBP cord-298525-hhcfrjrn 84 32 ) ) -RRB- cord-298525-hhcfrjrn 84 33 and and CC cord-298525-hhcfrjrn 84 34 the the DT cord-298525-hhcfrjrn 84 35 ON on JJ cord-298525-hhcfrjrn 84 36 inner inner JJ cord-298525-hhcfrjrn 84 37 sublamina sublamina NN cord-298525-hhcfrjrn 84 38 ( ( -LRB- cord-298525-hhcfrjrn 84 39 where where WRB cord-298525-hhcfrjrn 84 40 ON on IN cord-298525-hhcfrjrn 84 41 bipolar bipolar JJ cord-298525-hhcfrjrn 84 42 cells cell NNS cord-298525-hhcfrjrn 84 43 terminate terminate VBP cord-298525-hhcfrjrn 84 44 ) ) -RRB- cord-298525-hhcfrjrn 84 45 . . . cord-298525-hhcfrjrn 85 1 There there EX cord-298525-hhcfrjrn 85 2 are be VBP cord-298525-hhcfrjrn 85 3 also also RB cord-298525-hhcfrjrn 85 4 ON on JJ cord-298525-hhcfrjrn 85 5 and and CC cord-298525-hhcfrjrn 85 6 OFF off JJ cord-298525-hhcfrjrn 85 7 bands band NNS cord-298525-hhcfrjrn 85 8 of of IN cord-298525-hhcfrjrn 85 9 melanopsin melanopsin JJ cord-298525-hhcfrjrn 85 10 dendrites dendrite NNS cord-298525-hhcfrjrn 85 11 from from IN cord-298525-hhcfrjrn 85 12 the the DT cord-298525-hhcfrjrn 85 13 ipRGCs iprgcs JJ cord-298525-hhcfrjrn 85 14 , , , cord-298525-hhcfrjrn 85 15 but but CC cord-298525-hhcfrjrn 85 16 both both DT cord-298525-hhcfrjrn 85 17 lie lie VBP cord-298525-hhcfrjrn 85 18 outside outside RB cord-298525-hhcfrjrn 85 19 of of IN cord-298525-hhcfrjrn 85 20 the the DT cord-298525-hhcfrjrn 85 21 ON ON NNP cord-298525-hhcfrjrn 85 22 and and CC cord-298525-hhcfrjrn 85 23 OFF off JJ cord-298525-hhcfrjrn 85 24 cholinergic cholinergic JJ cord-298525-hhcfrjrn 85 25 bands band NNS cord-298525-hhcfrjrn 85 26 within within IN cord-298525-hhcfrjrn 85 27 the the DT cord-298525-hhcfrjrn 85 28 IPL IPL NNP cord-298525-hhcfrjrn 85 29 . . . cord-298525-hhcfrjrn 86 1 The the DT cord-298525-hhcfrjrn 86 2 bipolar bipolar JJ cord-298525-hhcfrjrn 86 3 cells cell NNS cord-298525-hhcfrjrn 86 4 are be VBP cord-298525-hhcfrjrn 86 5 photoreceptor photoreceptor NN cord-298525-hhcfrjrn 86 6 specific specific JJ cord-298525-hhcfrjrn 86 7 and and CC cord-298525-hhcfrjrn 86 8 the the DT cord-298525-hhcfrjrn 86 9 bipolar bipolar JJ cord-298525-hhcfrjrn 86 10 dendrites dendrite NNS cord-298525-hhcfrjrn 86 11 synapse synapse NN cord-298525-hhcfrjrn 86 12 exclusively exclusively RB cord-298525-hhcfrjrn 86 13 with with IN cord-298525-hhcfrjrn 86 14 either either CC cord-298525-hhcfrjrn 86 15 rod rod NN cord-298525-hhcfrjrn 86 16 or or CC cord-298525-hhcfrjrn 86 17 cone cone NN cord-298525-hhcfrjrn 86 18 cells cell NNS cord-298525-hhcfrjrn 86 19 . . . cord-298525-hhcfrjrn 87 1 The the DT cord-298525-hhcfrjrn 87 2 interneuron interneuron NN cord-298525-hhcfrjrn 87 3 and and CC cord-298525-hhcfrjrn 87 4 efferent efferent JJ cord-298525-hhcfrjrn 87 5 arms arm NNS cord-298525-hhcfrjrn 87 6 of of IN cord-298525-hhcfrjrn 87 7 pupil pupil NN cord-298525-hhcfrjrn 87 8 constriction constriction NN cord-298525-hhcfrjrn 87 9 are be VBP cord-298525-hhcfrjrn 87 10 summarised summarise VBN cord-298525-hhcfrjrn 87 11 in in IN cord-298525-hhcfrjrn 87 12 Figure Figure NNP cord-298525-hhcfrjrn 87 13 3 3 CD cord-298525-hhcfrjrn 87 14 . . . cord-298525-hhcfrjrn 88 1 The the DT cord-298525-hhcfrjrn 88 2 RGC RGC NNP cord-298525-hhcfrjrn 88 3 axons axon NNS cord-298525-hhcfrjrn 88 4 form form VBP cord-298525-hhcfrjrn 88 5 the the DT cord-298525-hhcfrjrn 88 6 first first JJ cord-298525-hhcfrjrn 88 7 interneuron interneuron NNP cord-298525-hhcfrjrn 88 8 arm arm NN cord-298525-hhcfrjrn 88 9 of of IN cord-298525-hhcfrjrn 88 10 the the DT cord-298525-hhcfrjrn 88 11 PLR PLR NNP cord-298525-hhcfrjrn 88 12 arc arc NNP cord-298525-hhcfrjrn 88 13 and and CC cord-298525-hhcfrjrn 88 14 carry carry VB cord-298525-hhcfrjrn 88 15 the the DT cord-298525-hhcfrjrn 88 16 neuronal neuronal JJ cord-298525-hhcfrjrn 88 17 signal signal NN cord-298525-hhcfrjrn 88 18 from from IN cord-298525-hhcfrjrn 88 19 the the DT cord-298525-hhcfrjrn 88 20 photoreceptors photoreceptor NNS cord-298525-hhcfrjrn 88 21 [ [ -LRB- cord-298525-hhcfrjrn 88 22 2 2 CD cord-298525-hhcfrjrn 88 23 ] ] -RRB- cord-298525-hhcfrjrn 88 24 . . . cord-298525-hhcfrjrn 89 1 The the DT cord-298525-hhcfrjrn 89 2 rod rod NN cord-298525-hhcfrjrn 89 3 and and CC cord-298525-hhcfrjrn 89 4 cone cone NN cord-298525-hhcfrjrn 89 5 cells cell NNS cord-298525-hhcfrjrn 89 6 are be VBP cord-298525-hhcfrjrn 89 7 located locate VBN cord-298525-hhcfrjrn 89 8 in in IN cord-298525-hhcfrjrn 89 9 the the DT cord-298525-hhcfrjrn 89 10 outer outer JJ cord-298525-hhcfrjrn 89 11 nuclear nuclear JJ cord-298525-hhcfrjrn 89 12 layer layer NN cord-298525-hhcfrjrn 89 13 ( ( -LRB- cord-298525-hhcfrjrn 89 14 ONL ONL NNP cord-298525-hhcfrjrn 89 15 ) ) -RRB- cord-298525-hhcfrjrn 89 16 , , , cord-298525-hhcfrjrn 89 17 which which WDT cord-298525-hhcfrjrn 89 18 is be VBZ cord-298525-hhcfrjrn 89 19 adjacent adjacent JJ cord-298525-hhcfrjrn 89 20 to to IN cord-298525-hhcfrjrn 89 21 the the DT cord-298525-hhcfrjrn 89 22 retinal retinal JJ cord-298525-hhcfrjrn 89 23 pigment pigment NN cord-298525-hhcfrjrn 89 24 epithelium epithelium NN cord-298525-hhcfrjrn 89 25 ( ( -LRB- cord-298525-hhcfrjrn 89 26 RPE RPE NNP cord-298525-hhcfrjrn 89 27 ) ) -RRB- cord-298525-hhcfrjrn 89 28 . . . cord-298525-hhcfrjrn 90 1 The the DT cord-298525-hhcfrjrn 90 2 horizontal horizontal JJ cord-298525-hhcfrjrn 90 3 cell cell NN cord-298525-hhcfrjrn 90 4 , , , cord-298525-hhcfrjrn 90 5 bipolar bipolar JJ cord-298525-hhcfrjrn 90 6 cell cell NN cord-298525-hhcfrjrn 90 7 and and CC cord-298525-hhcfrjrn 90 8 amacrine amacrine JJ cord-298525-hhcfrjrn 90 9 cell cell NN cord-298525-hhcfrjrn 90 10 somas soma NNS cord-298525-hhcfrjrn 90 11 are be VBP cord-298525-hhcfrjrn 90 12 located locate VBN cord-298525-hhcfrjrn 90 13 in in IN cord-298525-hhcfrjrn 90 14 the the DT cord-298525-hhcfrjrn 90 15 inner inner JJ cord-298525-hhcfrjrn 90 16 nuclear nuclear JJ cord-298525-hhcfrjrn 90 17 layer layer NN cord-298525-hhcfrjrn 90 18 ( ( -LRB- cord-298525-hhcfrjrn 90 19 INL INL NNP cord-298525-hhcfrjrn 90 20 ) ) -RRB- cord-298525-hhcfrjrn 90 21 , , , cord-298525-hhcfrjrn 90 22 whilst whilst IN cord-298525-hhcfrjrn 90 23 the the DT cord-298525-hhcfrjrn 90 24 ganglion ganglion NN cord-298525-hhcfrjrn 90 25 cell cell NN cord-298525-hhcfrjrn 90 26 somata somata NNP cord-298525-hhcfrjrn 90 27 are be VBP cord-298525-hhcfrjrn 90 28 located locate VBN cord-298525-hhcfrjrn 90 29 in in IN cord-298525-hhcfrjrn 90 30 the the DT cord-298525-hhcfrjrn 90 31 ganglion ganglion NN cord-298525-hhcfrjrn 90 32 cell cell NN cord-298525-hhcfrjrn 90 33 layer layer NN cord-298525-hhcfrjrn 90 34 ( ( -LRB- cord-298525-hhcfrjrn 90 35 GCL GCL NNP cord-298525-hhcfrjrn 90 36 ) ) -RRB- cord-298525-hhcfrjrn 90 37 . . . cord-298525-hhcfrjrn 91 1 The the DT cord-298525-hhcfrjrn 91 2 axon axon NN cord-298525-hhcfrjrn 91 3 terminals terminal NNS cord-298525-hhcfrjrn 91 4 of of IN cord-298525-hhcfrjrn 91 5 the the DT cord-298525-hhcfrjrn 91 6 bipolar bipolar JJ cord-298525-hhcfrjrn 91 7 cells cell NNS cord-298525-hhcfrjrn 91 8 stratify stratify VBP cord-298525-hhcfrjrn 91 9 at at IN cord-298525-hhcfrjrn 91 10 different different JJ cord-298525-hhcfrjrn 91 11 depths depth NNS cord-298525-hhcfrjrn 91 12 of of IN cord-298525-hhcfrjrn 91 13 the the DT cord-298525-hhcfrjrn 91 14 inner inner JJ cord-298525-hhcfrjrn 91 15 plexiform plexiform NNS cord-298525-hhcfrjrn 91 16 layer layer NN cord-298525-hhcfrjrn 91 17 , , , cord-298525-hhcfrjrn 91 18 which which WDT cord-298525-hhcfrjrn 91 19 is be VBZ cord-298525-hhcfrjrn 91 20 subdivided subdivide VBN cord-298525-hhcfrjrn 91 21 into into IN cord-298525-hhcfrjrn 91 22 the the DT cord-298525-hhcfrjrn 91 23 OFF off JJ cord-298525-hhcfrjrn 91 24 outer outer JJ cord-298525-hhcfrjrn 91 25 sublamina sublamina NN cord-298525-hhcfrjrn 91 26 ( ( -LRB- cord-298525-hhcfrjrn 91 27 where where WRB cord-298525-hhcfrjrn 91 28 OFF off RB cord-298525-hhcfrjrn 91 29 bipolar bipolar JJ cord-298525-hhcfrjrn 91 30 cells cell NNS cord-298525-hhcfrjrn 91 31 terminate terminate VBP cord-298525-hhcfrjrn 91 32 ) ) -RRB- cord-298525-hhcfrjrn 91 33 and and CC cord-298525-hhcfrjrn 91 34 the the DT cord-298525-hhcfrjrn 91 35 ON on JJ cord-298525-hhcfrjrn 91 36 inner inner JJ cord-298525-hhcfrjrn 91 37 sublamina sublamina NN cord-298525-hhcfrjrn 91 38 ( ( -LRB- cord-298525-hhcfrjrn 91 39 where where WRB cord-298525-hhcfrjrn 91 40 ON on IN cord-298525-hhcfrjrn 91 41 bipolar bipolar JJ cord-298525-hhcfrjrn 91 42 cells cell NNS cord-298525-hhcfrjrn 91 43 terminate terminate VBP cord-298525-hhcfrjrn 91 44 ) ) -RRB- cord-298525-hhcfrjrn 91 45 . . . cord-298525-hhcfrjrn 92 1 There there EX cord-298525-hhcfrjrn 92 2 are be VBP cord-298525-hhcfrjrn 92 3 also also RB cord-298525-hhcfrjrn 92 4 ON on JJ cord-298525-hhcfrjrn 92 5 and and CC cord-298525-hhcfrjrn 92 6 OFF off JJ cord-298525-hhcfrjrn 92 7 bands band NNS cord-298525-hhcfrjrn 92 8 of of IN cord-298525-hhcfrjrn 92 9 melanopsin melanopsin JJ cord-298525-hhcfrjrn 92 10 dendrites dendrite NNS cord-298525-hhcfrjrn 92 11 from from IN cord-298525-hhcfrjrn 92 12 the the DT cord-298525-hhcfrjrn 92 13 ipRGCs iprgcs JJ cord-298525-hhcfrjrn 92 14 , , , cord-298525-hhcfrjrn 92 15 but but CC cord-298525-hhcfrjrn 92 16 both both DT cord-298525-hhcfrjrn 92 17 lie lie VBP cord-298525-hhcfrjrn 92 18 outside outside RB cord-298525-hhcfrjrn 92 19 of of IN cord-298525-hhcfrjrn 92 20 the the DT cord-298525-hhcfrjrn 92 21 ON ON NNP cord-298525-hhcfrjrn 92 22 and and CC cord-298525-hhcfrjrn 92 23 OFF off JJ cord-298525-hhcfrjrn 92 24 cholinergic cholinergic JJ cord-298525-hhcfrjrn 92 25 bands band NNS cord-298525-hhcfrjrn 92 26 within within IN cord-298525-hhcfrjrn 92 27 the the DT cord-298525-hhcfrjrn 92 28 IPL IPL NNP cord-298525-hhcfrjrn 92 29 . . . cord-298525-hhcfrjrn 93 1 The the DT cord-298525-hhcfrjrn 93 2 bipolar bipolar JJ cord-298525-hhcfrjrn 93 3 cells cell NNS cord-298525-hhcfrjrn 93 4 are be VBP cord-298525-hhcfrjrn 93 5 photoreceptor photoreceptor NN cord-298525-hhcfrjrn 93 6 specific specific JJ cord-298525-hhcfrjrn 93 7 and and CC cord-298525-hhcfrjrn 93 8 the the DT cord-298525-hhcfrjrn 93 9 bipolar bipolar JJ cord-298525-hhcfrjrn 93 10 dendrites dendrite NNS cord-298525-hhcfrjrn 93 11 synapse synapse NN cord-298525-hhcfrjrn 93 12 exclusively exclusively RB cord-298525-hhcfrjrn 93 13 with with IN cord-298525-hhcfrjrn 93 14 either either CC cord-298525-hhcfrjrn 93 15 rod rod NN cord-298525-hhcfrjrn 93 16 or or CC cord-298525-hhcfrjrn 93 17 cone cone NN cord-298525-hhcfrjrn 93 18 cells cell NNS cord-298525-hhcfrjrn 93 19 . . . cord-298525-hhcfrjrn 94 1 The the DT cord-298525-hhcfrjrn 94 2 interneuron interneuron NN cord-298525-hhcfrjrn 94 3 and and CC cord-298525-hhcfrjrn 94 4 efferent efferent JJ cord-298525-hhcfrjrn 94 5 arms arm NNS cord-298525-hhcfrjrn 94 6 of of IN cord-298525-hhcfrjrn 94 7 pupil pupil NN cord-298525-hhcfrjrn 94 8 constriction constriction NN cord-298525-hhcfrjrn 94 9 are be VBP cord-298525-hhcfrjrn 94 10 summarised summarise VBN cord-298525-hhcfrjrn 94 11 in in IN cord-298525-hhcfrjrn 94 12 Figure Figure NNP cord-298525-hhcfrjrn 94 13 3 3 CD cord-298525-hhcfrjrn 94 14 . . . cord-298525-hhcfrjrn 95 1 The the DT cord-298525-hhcfrjrn 95 2 RGC RGC NNP cord-298525-hhcfrjrn 95 3 axons axon NNS cord-298525-hhcfrjrn 95 4 form form VBP cord-298525-hhcfrjrn 95 5 the the DT cord-298525-hhcfrjrn 95 6 first first JJ cord-298525-hhcfrjrn 95 7 interneuron interneuron NNP cord-298525-hhcfrjrn 95 8 arm arm NN cord-298525-hhcfrjrn 95 9 of of IN cord-298525-hhcfrjrn 95 10 the the DT cord-298525-hhcfrjrn 95 11 PLR PLR NNP cord-298525-hhcfrjrn 95 12 arc arc NNP cord-298525-hhcfrjrn 95 13 and and CC cord-298525-hhcfrjrn 95 14 carry carry VB cord-298525-hhcfrjrn 95 15 the the DT cord-298525-hhcfrjrn 95 16 neuronal neuronal JJ cord-298525-hhcfrjrn 95 17 signal signal NN cord-298525-hhcfrjrn 95 18 from from IN cord-298525-hhcfrjrn 95 19 the the DT cord-298525-hhcfrjrn 95 20 photoreceptors photoreceptor NNS cord-298525-hhcfrjrn 95 21 [ [ -LRB- cord-298525-hhcfrjrn 95 22 2 2 CD cord-298525-hhcfrjrn 95 23 ] ] -RRB- cord-298525-hhcfrjrn 95 24 . . . cord-298525-hhcfrjrn 95 25 . . . cord-298525-hhcfrjrn 96 1 The the DT cord-298525-hhcfrjrn 96 2 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 96 3 nervous nervous JJ cord-298525-hhcfrjrn 96 4 system system NN cord-298525-hhcfrjrn 96 5 is be VBZ cord-298525-hhcfrjrn 96 6 the the DT cord-298525-hhcfrjrn 96 7 main main JJ cord-298525-hhcfrjrn 96 8 system system NN cord-298525-hhcfrjrn 96 9 responsible responsible JJ cord-298525-hhcfrjrn 96 10 for for IN cord-298525-hhcfrjrn 96 11 pupil pupil NN cord-298525-hhcfrjrn 96 12 constriction constriction NN cord-298525-hhcfrjrn 96 13 in in IN cord-298525-hhcfrjrn 96 14 response response NN cord-298525-hhcfrjrn 96 15 to to IN cord-298525-hhcfrjrn 96 16 light light NN cord-298525-hhcfrjrn 96 17 . . . cord-298525-hhcfrjrn 97 1 The the DT cord-298525-hhcfrjrn 97 2 integrated integrated JJ cord-298525-hhcfrjrn 97 3 afferent afferent JJ cord-298525-hhcfrjrn 97 4 input input NN cord-298525-hhcfrjrn 97 5 is be VBZ cord-298525-hhcfrjrn 97 6 transmitted transmit VBN cord-298525-hhcfrjrn 97 7 along along IN cord-298525-hhcfrjrn 97 8 the the DT cord-298525-hhcfrjrn 97 9 axons axon NNS cord-298525-hhcfrjrn 97 10 of of IN cord-298525-hhcfrjrn 97 11 the the DT cord-298525-hhcfrjrn 97 12 retinal retinal JJ cord-298525-hhcfrjrn 97 13 ganglion ganglion NN cord-298525-hhcfrjrn 97 14 cells cell NNS cord-298525-hhcfrjrn 97 15 ( ( -LRB- cord-298525-hhcfrjrn 97 16 RGC RGC NNP cord-298525-hhcfrjrn 97 17 ) ) -RRB- cord-298525-hhcfrjrn 97 18 , , , cord-298525-hhcfrjrn 97 19 which which WDT cord-298525-hhcfrjrn 97 20 contribute contribute VBP cord-298525-hhcfrjrn 97 21 to to IN cord-298525-hhcfrjrn 97 22 the the DT cord-298525-hhcfrjrn 97 23 optic optic JJ cord-298525-hhcfrjrn 97 24 nerve nerve NN cord-298525-hhcfrjrn 97 25 . . . cord-298525-hhcfrjrn 98 1 At at IN cord-298525-hhcfrjrn 98 2 the the DT cord-298525-hhcfrjrn 98 3 optic optic JJ cord-298525-hhcfrjrn 98 4 chiasm chiasm NN cord-298525-hhcfrjrn 98 5 , , , cord-298525-hhcfrjrn 98 6 nerves nerve NNS cord-298525-hhcfrjrn 98 7 from from IN cord-298525-hhcfrjrn 98 8 the the DT cord-298525-hhcfrjrn 98 9 nasal nasal NN cord-298525-hhcfrjrn 98 10 retina retina NNP cord-298525-hhcfrjrn 98 11 cross cross NN cord-298525-hhcfrjrn 98 12 to to IN cord-298525-hhcfrjrn 98 13 the the DT cord-298525-hhcfrjrn 98 14 contralateral contralateral JJ cord-298525-hhcfrjrn 98 15 side side NN cord-298525-hhcfrjrn 98 16 , , , cord-298525-hhcfrjrn 98 17 whilst whilst IN cord-298525-hhcfrjrn 98 18 nerves nerve NNS cord-298525-hhcfrjrn 98 19 from from IN cord-298525-hhcfrjrn 98 20 the the DT cord-298525-hhcfrjrn 98 21 temporal temporal JJ cord-298525-hhcfrjrn 98 22 retina retina NN cord-298525-hhcfrjrn 98 23 continue continue VBP cord-298525-hhcfrjrn 98 24 ipsilaterally ipsilaterally RB cord-298525-hhcfrjrn 98 25 . . . cord-298525-hhcfrjrn 99 1 The the DT cord-298525-hhcfrjrn 99 2 pupillary pupillary JJ cord-298525-hhcfrjrn 99 3 RGC rgc NN cord-298525-hhcfrjrn 99 4 axons axon NNS cord-298525-hhcfrjrn 99 5 exit exit VBP cord-298525-hhcfrjrn 99 6 the the DT cord-298525-hhcfrjrn 99 7 optic optic JJ cord-298525-hhcfrjrn 99 8 tract tract NN cord-298525-hhcfrjrn 99 9 and and CC cord-298525-hhcfrjrn 99 10 synapse synapse NN cord-298525-hhcfrjrn 99 11 at at IN cord-298525-hhcfrjrn 99 12 the the DT cord-298525-hhcfrjrn 99 13 pretectal pretectal NNP cord-298525-hhcfrjrn 99 14 olivary olivary NNP cord-298525-hhcfrjrn 99 15 nucleus nucleus NNP cord-298525-hhcfrjrn 99 16 . . . cord-298525-hhcfrjrn 100 1 Pretectal Pretectal NNP cord-298525-hhcfrjrn 100 2 neurons neuron NNS cord-298525-hhcfrjrn 100 3 are be VBP cord-298525-hhcfrjrn 100 4 projected project VBN cord-298525-hhcfrjrn 100 5 either either CC cord-298525-hhcfrjrn 100 6 ipsilaterally ipsilaterally RB cord-298525-hhcfrjrn 100 7 or or CC cord-298525-hhcfrjrn 100 8 contralaterally contralaterally RB cord-298525-hhcfrjrn 100 9 , , , cord-298525-hhcfrjrn 100 10 across across IN cord-298525-hhcfrjrn 100 11 the the DT cord-298525-hhcfrjrn 100 12 posterior posterior JJ cord-298525-hhcfrjrn 100 13 commissure commissure NN cord-298525-hhcfrjrn 100 14 , , , cord-298525-hhcfrjrn 100 15 to to IN cord-298525-hhcfrjrn 100 16 the the DT cord-298525-hhcfrjrn 100 17 Edinger Edinger NNP cord-298525-hhcfrjrn 100 18 - - HYPH cord-298525-hhcfrjrn 100 19 Westphal Westphal NNP cord-298525-hhcfrjrn 100 20 nucleus nucleus NN cord-298525-hhcfrjrn 100 21 . . . cord-298525-hhcfrjrn 101 1 From from IN cord-298525-hhcfrjrn 101 2 there there RB cord-298525-hhcfrjrn 101 3 , , , cord-298525-hhcfrjrn 101 4 the the DT cord-298525-hhcfrjrn 101 5 pre pre JJ cord-298525-hhcfrjrn 101 6 - - JJ cord-298525-hhcfrjrn 101 7 ganglionic ganglionic JJ cord-298525-hhcfrjrn 101 8 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 101 9 fibres fibre NNS cord-298525-hhcfrjrn 101 10 travel travel VBP cord-298525-hhcfrjrn 101 11 with with IN cord-298525-hhcfrjrn 101 12 the the DT cord-298525-hhcfrjrn 101 13 oculomotor oculomotor NN cord-298525-hhcfrjrn 101 14 , , , cord-298525-hhcfrjrn 101 15 or or CC cord-298525-hhcfrjrn 101 16 III iii CD cord-298525-hhcfrjrn 101 17 cranial cranial JJ cord-298525-hhcfrjrn 101 18 nerve nerve NN cord-298525-hhcfrjrn 101 19 , , , cord-298525-hhcfrjrn 101 20 and and CC cord-298525-hhcfrjrn 101 21 synapse synapse NN cord-298525-hhcfrjrn 101 22 at at IN cord-298525-hhcfrjrn 101 23 the the DT cord-298525-hhcfrjrn 101 24 ciliary ciliary NN cord-298525-hhcfrjrn 101 25 ganglion ganglion NN cord-298525-hhcfrjrn 101 26 . . . cord-298525-hhcfrjrn 102 1 The the DT cord-298525-hhcfrjrn 102 2 post post JJ cord-298525-hhcfrjrn 102 3 - - JJ cord-298525-hhcfrjrn 102 4 ganglionic ganglionic JJ cord-298525-hhcfrjrn 102 5 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 102 6 neurons neuron NNS cord-298525-hhcfrjrn 102 7 ( ( -LRB- cord-298525-hhcfrjrn 102 8 short short JJ cord-298525-hhcfrjrn 102 9 ciliary ciliary NN cord-298525-hhcfrjrn 102 10 nerves nerve NNS cord-298525-hhcfrjrn 102 11 ) ) -RRB- cord-298525-hhcfrjrn 102 12 travel travel VBP cord-298525-hhcfrjrn 102 13 to to IN cord-298525-hhcfrjrn 102 14 and and CC cord-298525-hhcfrjrn 102 15 innervate innervate VB cord-298525-hhcfrjrn 102 16 the the DT cord-298525-hhcfrjrn 102 17 contraction contraction NN cord-298525-hhcfrjrn 102 18 of of IN cord-298525-hhcfrjrn 102 19 the the DT cord-298525-hhcfrjrn 102 20 iris iris NNP cord-298525-hhcfrjrn 102 21 sphincter sphincter NN cord-298525-hhcfrjrn 102 22 muscle muscle NN cord-298525-hhcfrjrn 102 23 via via IN cord-298525-hhcfrjrn 102 24 the the DT cord-298525-hhcfrjrn 102 25 release release NN cord-298525-hhcfrjrn 102 26 of of IN cord-298525-hhcfrjrn 102 27 acetylcholine acetylcholine NN cord-298525-hhcfrjrn 102 28 at at IN cord-298525-hhcfrjrn 102 29 the the DT cord-298525-hhcfrjrn 102 30 neuromuscular neuromuscular JJ cord-298525-hhcfrjrn 102 31 junction junction NN cord-298525-hhcfrjrn 102 32 , , , cord-298525-hhcfrjrn 102 33 resulting result VBG cord-298525-hhcfrjrn 102 34 in in IN cord-298525-hhcfrjrn 102 35 pupil pupil NN cord-298525-hhcfrjrn 102 36 constriction constriction NN cord-298525-hhcfrjrn 102 37 . . . cord-298525-hhcfrjrn 103 1 At at IN cord-298525-hhcfrjrn 103 2 the the DT cord-298525-hhcfrjrn 103 3 optic optic JJ cord-298525-hhcfrjrn 103 4 chiasma chiasma NNP cord-298525-hhcfrjrn 103 5 , , , cord-298525-hhcfrjrn 103 6 approximately approximately RB cord-298525-hhcfrjrn 103 7 half half PDT cord-298525-hhcfrjrn 103 8 the the DT cord-298525-hhcfrjrn 103 9 RGCs rgc NNS cord-298525-hhcfrjrn 103 10 from from IN cord-298525-hhcfrjrn 103 11 the the DT cord-298525-hhcfrjrn 103 12 nasal nasal NN cord-298525-hhcfrjrn 103 13 plane plane NN cord-298525-hhcfrjrn 103 14 in in IN cord-298525-hhcfrjrn 103 15 each each DT cord-298525-hhcfrjrn 103 16 eye eye NN cord-298525-hhcfrjrn 103 17 decussate decussate NN cord-298525-hhcfrjrn 103 18 to to IN cord-298525-hhcfrjrn 103 19 the the DT cord-298525-hhcfrjrn 103 20 opposite opposite JJ cord-298525-hhcfrjrn 103 21 optic optic JJ cord-298525-hhcfrjrn 103 22 tract tract NN cord-298525-hhcfrjrn 103 23 [ [ -LRB- cord-298525-hhcfrjrn 103 24 41 41 CD cord-298525-hhcfrjrn 103 25 ] ] -RRB- cord-298525-hhcfrjrn 103 26 . . . cord-298525-hhcfrjrn 104 1 At at IN cord-298525-hhcfrjrn 104 2 the the DT cord-298525-hhcfrjrn 104 3 terminus terminus NN cord-298525-hhcfrjrn 104 4 of of IN cord-298525-hhcfrjrn 104 5 the the DT cord-298525-hhcfrjrn 104 6 optic optic JJ cord-298525-hhcfrjrn 104 7 tract tract NN cord-298525-hhcfrjrn 104 8 , , , cord-298525-hhcfrjrn 104 9 the the DT cord-298525-hhcfrjrn 104 10 axons axon NNS cord-298525-hhcfrjrn 104 11 of of IN cord-298525-hhcfrjrn 104 12 RGCs rgc NNS cord-298525-hhcfrjrn 104 13 responsible responsible JJ cord-298525-hhcfrjrn 104 14 for for IN cord-298525-hhcfrjrn 104 15 the the DT cord-298525-hhcfrjrn 104 16 PLR plr NN cord-298525-hhcfrjrn 104 17 separate separate JJ cord-298525-hhcfrjrn 104 18 from from IN cord-298525-hhcfrjrn 104 19 the the DT cord-298525-hhcfrjrn 104 20 visual visual JJ cord-298525-hhcfrjrn 104 21 axons axon NNS cord-298525-hhcfrjrn 104 22 and and CC cord-298525-hhcfrjrn 104 23 carry carry VB cord-298525-hhcfrjrn 104 24 the the DT cord-298525-hhcfrjrn 104 25 afferent afferent JJ cord-298525-hhcfrjrn 104 26 pupillomotor pupillomotor NN cord-298525-hhcfrjrn 104 27 signal signal NN cord-298525-hhcfrjrn 104 28 through through IN cord-298525-hhcfrjrn 104 29 the the DT cord-298525-hhcfrjrn 104 30 brachium brachium NN cord-298525-hhcfrjrn 104 31 of of IN cord-298525-hhcfrjrn 104 32 the the DT cord-298525-hhcfrjrn 104 33 superior superior NNP cord-298525-hhcfrjrn 104 34 colliculus colliculus NNP cord-298525-hhcfrjrn 104 35 to to IN cord-298525-hhcfrjrn 104 36 synapse synapse NN cord-298525-hhcfrjrn 104 37 at at IN cord-298525-hhcfrjrn 104 38 the the DT cord-298525-hhcfrjrn 104 39 pretectal pretectal NNP cord-298525-hhcfrjrn 104 40 olivary olivary NNP cord-298525-hhcfrjrn 104 41 nucleus nucleus NN cord-298525-hhcfrjrn 104 42 in in IN cord-298525-hhcfrjrn 104 43 the the DT cord-298525-hhcfrjrn 104 44 dorsal dorsal JJ cord-298525-hhcfrjrn 104 45 midbrain midbrain NN cord-298525-hhcfrjrn 104 46 [ [ -LRB- cord-298525-hhcfrjrn 104 47 8 8 CD cord-298525-hhcfrjrn 104 48 ] ] -RRB- cord-298525-hhcfrjrn 104 49 . . . cord-298525-hhcfrjrn 105 1 The the DT cord-298525-hhcfrjrn 105 2 pretectal pretectal JJ cord-298525-hhcfrjrn 105 3 neurons neuron NNS cord-298525-hhcfrjrn 105 4 integrate integrate VBP cord-298525-hhcfrjrn 105 5 the the DT cord-298525-hhcfrjrn 105 6 input input NN cord-298525-hhcfrjrn 105 7 signals signal NNS cord-298525-hhcfrjrn 105 8 ( ( -LRB- cord-298525-hhcfrjrn 105 9 retinal retinal JJ cord-298525-hhcfrjrn 105 10 , , , cord-298525-hhcfrjrn 105 11 supranuclear supranuclear NN cord-298525-hhcfrjrn 105 12 and and CC cord-298525-hhcfrjrn 105 13 infranuclear infranuclear NNP cord-298525-hhcfrjrn 105 14 ) ) -RRB- cord-298525-hhcfrjrn 105 15 , , , cord-298525-hhcfrjrn 105 16 that that WDT cord-298525-hhcfrjrn 105 17 modulate modulate VBP cord-298525-hhcfrjrn 105 18 the the DT cord-298525-hhcfrjrn 105 19 PLR plr NN cord-298525-hhcfrjrn 105 20 and and CC cord-298525-hhcfrjrn 105 21 form form VB cord-298525-hhcfrjrn 105 22 the the DT cord-298525-hhcfrjrn 105 23 second second JJ cord-298525-hhcfrjrn 105 24 interneuron interneuron NN cord-298525-hhcfrjrn 105 25 of of IN cord-298525-hhcfrjrn 105 26 the the DT cord-298525-hhcfrjrn 105 27 reflex reflex NNP cord-298525-hhcfrjrn 105 28 arc arc NNP cord-298525-hhcfrjrn 105 29 . . . cord-298525-hhcfrjrn 106 1 These these DT cord-298525-hhcfrjrn 106 2 pretectal pretectal JJ cord-298525-hhcfrjrn 106 3 nuclei nucleus NNS cord-298525-hhcfrjrn 106 4 project project VBP cord-298525-hhcfrjrn 106 5 to to IN cord-298525-hhcfrjrn 106 6 either either CC cord-298525-hhcfrjrn 106 7 the the DT cord-298525-hhcfrjrn 106 8 ipsilateral ipsilateral JJ cord-298525-hhcfrjrn 106 9 or or CC cord-298525-hhcfrjrn 106 10 contralateral contralateral JJ cord-298525-hhcfrjrn 106 11 Edinger Edinger NNP cord-298525-hhcfrjrn 106 12 - - HYPH cord-298525-hhcfrjrn 106 13 Westphal Westphal NNP cord-298525-hhcfrjrn 106 14 ( ( -LRB- cord-298525-hhcfrjrn 106 15 EW ew UH cord-298525-hhcfrjrn 106 16 ) ) -RRB- cord-298525-hhcfrjrn 106 17 nucleus nucleus NN cord-298525-hhcfrjrn 106 18 within within IN cord-298525-hhcfrjrn 106 19 the the DT cord-298525-hhcfrjrn 106 20 oculomotor oculomotor NN cord-298525-hhcfrjrn 106 21 nuclear nuclear NN cord-298525-hhcfrjrn 106 22 complex complex NN cord-298525-hhcfrjrn 106 23 , , , cord-298525-hhcfrjrn 106 24 which which WDT cord-298525-hhcfrjrn 106 25 contain contain VBP cord-298525-hhcfrjrn 106 26 the the DT cord-298525-hhcfrjrn 106 27 pre pre JJ cord-298525-hhcfrjrn 106 28 - - JJ cord-298525-hhcfrjrn 106 29 ganglionic ganglionic JJ cord-298525-hhcfrjrn 106 30 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 106 31 neurons neuron NNS cord-298525-hhcfrjrn 106 32 that that WDT cord-298525-hhcfrjrn 106 33 control control VBP cord-298525-hhcfrjrn 106 34 the the DT cord-298525-hhcfrjrn 106 35 iris iris NNP cord-298525-hhcfrjrn 106 36 sphincter sphincter NN cord-298525-hhcfrjrn 106 37 [ [ -LRB- cord-298525-hhcfrjrn 106 38 42 42 CD cord-298525-hhcfrjrn 106 39 ] ] -RRB- cord-298525-hhcfrjrn 106 40 . . . cord-298525-hhcfrjrn 107 1 The the DT cord-298525-hhcfrjrn 107 2 bilateral bilateral JJ cord-298525-hhcfrjrn 107 3 neuron neuron NN cord-298525-hhcfrjrn 107 4 projection projection NN cord-298525-hhcfrjrn 107 5 results result NNS cord-298525-hhcfrjrn 107 6 in in IN cord-298525-hhcfrjrn 107 7 a a DT cord-298525-hhcfrjrn 107 8 double double JJ cord-298525-hhcfrjrn 107 9 decussation decussation NN cord-298525-hhcfrjrn 107 10 of of IN cord-298525-hhcfrjrn 107 11 pupillary pupillary JJ cord-298525-hhcfrjrn 107 12 fibres fibre NNS cord-298525-hhcfrjrn 107 13 , , , cord-298525-hhcfrjrn 107 14 first first RB cord-298525-hhcfrjrn 107 15 at at IN cord-298525-hhcfrjrn 107 16 the the DT cord-298525-hhcfrjrn 107 17 optic optic JJ cord-298525-hhcfrjrn 107 18 chiasm chiasm NN cord-298525-hhcfrjrn 107 19 and and CC cord-298525-hhcfrjrn 107 20 then then RB cord-298525-hhcfrjrn 107 21 within within IN cord-298525-hhcfrjrn 107 22 the the DT cord-298525-hhcfrjrn 107 23 pretectal pretectal JJ cord-298525-hhcfrjrn 107 24 area area NN cord-298525-hhcfrjrn 107 25 , , , cord-298525-hhcfrjrn 107 26 and and CC cord-298525-hhcfrjrn 107 27 ensures ensure VBZ cord-298525-hhcfrjrn 107 28 each each DT cord-298525-hhcfrjrn 107 29 EW EW NNP cord-298525-hhcfrjrn 107 30 nucleus nucleus NN cord-298525-hhcfrjrn 107 31 receives receive VBZ cord-298525-hhcfrjrn 107 32 information information NN cord-298525-hhcfrjrn 107 33 about about IN cord-298525-hhcfrjrn 107 34 the the DT cord-298525-hhcfrjrn 107 35 level level NN cord-298525-hhcfrjrn 107 36 of of IN cord-298525-hhcfrjrn 107 37 incoming incoming JJ cord-298525-hhcfrjrn 107 38 light light NN cord-298525-hhcfrjrn 107 39 from from IN cord-298525-hhcfrjrn 107 40 each each DT cord-298525-hhcfrjrn 107 41 eye eye NN cord-298525-hhcfrjrn 107 42 . . . cord-298525-hhcfrjrn 108 1 Therefore therefore RB cord-298525-hhcfrjrn 108 2 , , , cord-298525-hhcfrjrn 108 3 unilateral unilateral JJ cord-298525-hhcfrjrn 108 4 light light JJ cord-298525-hhcfrjrn 108 5 stimulation stimulation NN cord-298525-hhcfrjrn 108 6 causes cause VBZ cord-298525-hhcfrjrn 108 7 an an DT cord-298525-hhcfrjrn 108 8 equal equal JJ cord-298525-hhcfrjrn 108 9 direct direct JJ cord-298525-hhcfrjrn 108 10 and and CC cord-298525-hhcfrjrn 108 11 consensual consensual JJ cord-298525-hhcfrjrn 108 12 pupillary pupillary JJ cord-298525-hhcfrjrn 108 13 constriction constriction NN cord-298525-hhcfrjrn 108 14 . . . cord-298525-hhcfrjrn 109 1 However however RB cord-298525-hhcfrjrn 109 2 , , , cord-298525-hhcfrjrn 109 3 contraction contraction NN cord-298525-hhcfrjrn 109 4 anisocoria anisocoria NN cord-298525-hhcfrjrn 109 5 , , , cord-298525-hhcfrjrn 109 6 whereby whereby WRB cord-298525-hhcfrjrn 109 7 the the DT cord-298525-hhcfrjrn 109 8 direct direct JJ cord-298525-hhcfrjrn 109 9 pupillary pupillary JJ cord-298525-hhcfrjrn 109 10 constriction constriction NN cord-298525-hhcfrjrn 109 11 is be VBZ cord-298525-hhcfrjrn 109 12 slightly slightly RB cord-298525-hhcfrjrn 109 13 stronger strong JJR cord-298525-hhcfrjrn 109 14 than than IN cord-298525-hhcfrjrn 109 15 the the DT cord-298525-hhcfrjrn 109 16 consensual consensual JJ cord-298525-hhcfrjrn 109 17 reaction reaction NN cord-298525-hhcfrjrn 109 18 , , , cord-298525-hhcfrjrn 109 19 may may MD cord-298525-hhcfrjrn 109 20 present present VB cord-298525-hhcfrjrn 109 21 if if IN cord-298525-hhcfrjrn 109 22 asymmetry asymmetry NN cord-298525-hhcfrjrn 109 23 occurs occur VBZ cord-298525-hhcfrjrn 109 24 during during IN cord-298525-hhcfrjrn 109 25 crossing crossing NN cord-298525-hhcfrjrn 109 26 of of IN cord-298525-hhcfrjrn 109 27 fibres fibre NNS cord-298525-hhcfrjrn 109 28 at at IN cord-298525-hhcfrjrn 109 29 the the DT cord-298525-hhcfrjrn 109 30 chiasm chiasm NNP cord-298525-hhcfrjrn 109 31 or or CC cord-298525-hhcfrjrn 109 32 pretectal pretectal NNP cord-298525-hhcfrjrn 109 33 olivary olivary NNP cord-298525-hhcfrjrn 109 34 nucleus nucleus NN cord-298525-hhcfrjrn 109 35 ; ; : cord-298525-hhcfrjrn 109 36 this this DT cord-298525-hhcfrjrn 109 37 is be VBZ cord-298525-hhcfrjrn 109 38 normally normally RB cord-298525-hhcfrjrn 109 39 clinically clinically RB cord-298525-hhcfrjrn 109 40 insignificant insignificant JJ cord-298525-hhcfrjrn 109 41 [ [ -LRB- cord-298525-hhcfrjrn 109 42 8 8 CD cord-298525-hhcfrjrn 109 43 ] ] -RRB- cord-298525-hhcfrjrn 109 44 . . . cord-298525-hhcfrjrn 110 1 From from IN cord-298525-hhcfrjrn 110 2 the the DT cord-298525-hhcfrjrn 110 3 EW EW NNP cord-298525-hhcfrjrn 110 4 nuclei nucleus NNS cord-298525-hhcfrjrn 110 5 , , , cord-298525-hhcfrjrn 110 6 the the DT cord-298525-hhcfrjrn 110 7 efferent efferent JJ cord-298525-hhcfrjrn 110 8 pre pre JJ cord-298525-hhcfrjrn 110 9 - - JJ cord-298525-hhcfrjrn 110 10 ganglionic ganglionic JJ cord-298525-hhcfrjrn 110 11 axons axon NNS cord-298525-hhcfrjrn 110 12 pass pass VBP cord-298525-hhcfrjrn 110 13 into into IN cord-298525-hhcfrjrn 110 14 the the DT cord-298525-hhcfrjrn 110 15 right right NN cord-298525-hhcfrjrn 110 16 and and CC cord-298525-hhcfrjrn 110 17 left left JJ cord-298525-hhcfrjrn 110 18 fascicles fascicle NNS cord-298525-hhcfrjrn 110 19 of of IN cord-298525-hhcfrjrn 110 20 the the DT cord-298525-hhcfrjrn 110 21 oculomotor oculomotor NN cord-298525-hhcfrjrn 110 22 nerve nerve NN cord-298525-hhcfrjrn 110 23 ( ( -LRB- cord-298525-hhcfrjrn 110 24 third third JJ cord-298525-hhcfrjrn 110 25 nerve nerve NN cord-298525-hhcfrjrn 110 26 ) ) -RRB- cord-298525-hhcfrjrn 110 27 to to TO cord-298525-hhcfrjrn 110 28 join join VB cord-298525-hhcfrjrn 110 29 the the DT cord-298525-hhcfrjrn 110 30 motor motor NN cord-298525-hhcfrjrn 110 31 axons axon NNS cord-298525-hhcfrjrn 110 32 destined destine VBN cord-298525-hhcfrjrn 110 33 for for IN cord-298525-hhcfrjrn 110 34 the the DT cord-298525-hhcfrjrn 110 35 eye eye NN cord-298525-hhcfrjrn 110 36 muscles muscle NNS cord-298525-hhcfrjrn 110 37 ( ( -LRB- cord-298525-hhcfrjrn 110 38 Figure figure NN cord-298525-hhcfrjrn 110 39 3 3 CD cord-298525-hhcfrjrn 110 40 ) ) -RRB- cord-298525-hhcfrjrn 110 41 . . . cord-298525-hhcfrjrn 111 1 The the DT cord-298525-hhcfrjrn 111 2 oculomotor oculomotor NN cord-298525-hhcfrjrn 111 3 nerve nerve NN cord-298525-hhcfrjrn 111 4 bifurcates bifurcate VBZ cord-298525-hhcfrjrn 111 5 into into IN cord-298525-hhcfrjrn 111 6 a a DT cord-298525-hhcfrjrn 111 7 superior superior JJ cord-298525-hhcfrjrn 111 8 and and CC cord-298525-hhcfrjrn 111 9 inferior inferior JJ cord-298525-hhcfrjrn 111 10 division division NN cord-298525-hhcfrjrn 111 11 near near IN cord-298525-hhcfrjrn 111 12 the the DT cord-298525-hhcfrjrn 111 13 anterior anterior JJ cord-298525-hhcfrjrn 111 14 cavernous cavernous JJ cord-298525-hhcfrjrn 111 15 sinus sinus NN cord-298525-hhcfrjrn 111 16 . . . cord-298525-hhcfrjrn 112 1 The the DT cord-298525-hhcfrjrn 112 2 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 112 3 fibres fibre NNS cord-298525-hhcfrjrn 112 4 travel travel VBP cord-298525-hhcfrjrn 112 5 with with IN cord-298525-hhcfrjrn 112 6 the the DT cord-298525-hhcfrjrn 112 7 inferior inferior JJ cord-298525-hhcfrjrn 112 8 division division NN cord-298525-hhcfrjrn 112 9 through through IN cord-298525-hhcfrjrn 112 10 the the DT cord-298525-hhcfrjrn 112 11 superior superior JJ cord-298525-hhcfrjrn 112 12 orbital orbital JJ cord-298525-hhcfrjrn 112 13 fissure fissure NN cord-298525-hhcfrjrn 112 14 toward toward IN cord-298525-hhcfrjrn 112 15 the the DT cord-298525-hhcfrjrn 112 16 orbital orbital JJ cord-298525-hhcfrjrn 112 17 apex apex NN cord-298525-hhcfrjrn 112 18 and and CC cord-298525-hhcfrjrn 112 19 synapse synapse NN cord-298525-hhcfrjrn 112 20 at at IN cord-298525-hhcfrjrn 112 21 the the DT cord-298525-hhcfrjrn 112 22 ciliary ciliary NN cord-298525-hhcfrjrn 112 23 ganglion ganglion NN cord-298525-hhcfrjrn 112 24 ( ( -LRB- cord-298525-hhcfrjrn 112 25 CG CG NNP cord-298525-hhcfrjrn 112 26 ) ) -RRB- cord-298525-hhcfrjrn 112 27 . . . cord-298525-hhcfrjrn 113 1 The the DT cord-298525-hhcfrjrn 113 2 short short JJ cord-298525-hhcfrjrn 113 3 ciliary ciliary NN cord-298525-hhcfrjrn 113 4 ( ( -LRB- cord-298525-hhcfrjrn 113 5 post post JJ cord-298525-hhcfrjrn 113 6 - - JJ cord-298525-hhcfrjrn 113 7 ganglionic ganglionic JJ cord-298525-hhcfrjrn 113 8 ) ) -RRB- cord-298525-hhcfrjrn 113 9 nerves nerve NNS cord-298525-hhcfrjrn 113 10 pierce pierce VBP cord-298525-hhcfrjrn 113 11 the the DT cord-298525-hhcfrjrn 113 12 globe globe NN cord-298525-hhcfrjrn 113 13 around around IN cord-298525-hhcfrjrn 113 14 the the DT cord-298525-hhcfrjrn 113 15 optic optic JJ cord-298525-hhcfrjrn 113 16 nerve nerve NN cord-298525-hhcfrjrn 113 17 and and CC cord-298525-hhcfrjrn 113 18 pass pass VB cord-298525-hhcfrjrn 113 19 between between IN cord-298525-hhcfrjrn 113 20 the the DT cord-298525-hhcfrjrn 113 21 choroid choroid NN cord-298525-hhcfrjrn 113 22 and and CC cord-298525-hhcfrjrn 113 23 sclera sclera NN cord-298525-hhcfrjrn 113 24 toward toward IN cord-298525-hhcfrjrn 113 25 the the DT cord-298525-hhcfrjrn 113 26 iris iris NN cord-298525-hhcfrjrn 113 27 . . . cord-298525-hhcfrjrn 114 1 These these DT cord-298525-hhcfrjrn 114 2 nerves nerve NNS cord-298525-hhcfrjrn 114 3 innervate innervate VBP cord-298525-hhcfrjrn 114 4 the the DT cord-298525-hhcfrjrn 114 5 contraction contraction NN cord-298525-hhcfrjrn 114 6 of of IN cord-298525-hhcfrjrn 114 7 the the DT cord-298525-hhcfrjrn 114 8 iris iris NNP cord-298525-hhcfrjrn 114 9 sphincter sphincter NN cord-298525-hhcfrjrn 114 10 muscle muscle NN cord-298525-hhcfrjrn 114 11 via via IN cord-298525-hhcfrjrn 114 12 the the DT cord-298525-hhcfrjrn 114 13 neurotransmitter neurotransmitter NN cord-298525-hhcfrjrn 114 14 acetylcholine acetylcholine NN cord-298525-hhcfrjrn 114 15 ( ( -LRB- cord-298525-hhcfrjrn 114 16 ACh ACh NNP cord-298525-hhcfrjrn 114 17 ) ) -RRB- cord-298525-hhcfrjrn 114 18 , , , cord-298525-hhcfrjrn 114 19 resulting result VBG cord-298525-hhcfrjrn 114 20 in in IN cord-298525-hhcfrjrn 114 21 constriction constriction NN cord-298525-hhcfrjrn 114 22 of of IN cord-298525-hhcfrjrn 114 23 the the DT cord-298525-hhcfrjrn 114 24 pupil pupil NN cord-298525-hhcfrjrn 114 25 . . . cord-298525-hhcfrjrn 115 1 Dilation dilation NN cord-298525-hhcfrjrn 115 2 of of IN cord-298525-hhcfrjrn 115 3 the the DT cord-298525-hhcfrjrn 115 4 pupil pupil NN cord-298525-hhcfrjrn 115 5 following follow VBG cord-298525-hhcfrjrn 115 6 a a DT cord-298525-hhcfrjrn 115 7 light light JJ cord-298525-hhcfrjrn 115 8 stimulus stimulus NN cord-298525-hhcfrjrn 115 9 occurs occur VBZ cord-298525-hhcfrjrn 115 10 through through IN cord-298525-hhcfrjrn 115 11 two two CD cord-298525-hhcfrjrn 115 12 integrated integrate VBN cord-298525-hhcfrjrn 115 13 processes process NNS cord-298525-hhcfrjrn 115 14 driven drive VBN cord-298525-hhcfrjrn 115 15 by by IN cord-298525-hhcfrjrn 115 16 the the DT cord-298525-hhcfrjrn 115 17 sympathetic sympathetic JJ cord-298525-hhcfrjrn 115 18 neurons neuron NNS cord-298525-hhcfrjrn 115 19 and and CC cord-298525-hhcfrjrn 115 20 corresponds correspond VBZ cord-298525-hhcfrjrn 115 21 to to IN cord-298525-hhcfrjrn 115 22 the the DT cord-298525-hhcfrjrn 115 23 recovery recovery NN cord-298525-hhcfrjrn 115 24 phase phase NN cord-298525-hhcfrjrn 115 25 of of IN cord-298525-hhcfrjrn 115 26 the the DT cord-298525-hhcfrjrn 115 27 PLR plr NN cord-298525-hhcfrjrn 115 28 and and CC cord-298525-hhcfrjrn 115 29 is be VBZ cord-298525-hhcfrjrn 115 30 summarised summarise VBN cord-298525-hhcfrjrn 115 31 in in IN cord-298525-hhcfrjrn 115 32 Figure Figure NNP cord-298525-hhcfrjrn 115 33 4 4 CD cord-298525-hhcfrjrn 115 34 . . . cord-298525-hhcfrjrn 116 1 Firstly firstly RB cord-298525-hhcfrjrn 116 2 , , , cord-298525-hhcfrjrn 116 3 the the DT cord-298525-hhcfrjrn 116 4 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 116 5 innervation innervation NN cord-298525-hhcfrjrn 116 6 of of IN cord-298525-hhcfrjrn 116 7 the the DT cord-298525-hhcfrjrn 116 8 pupil pupil NN cord-298525-hhcfrjrn 116 9 sphincter sphincter NN cord-298525-hhcfrjrn 116 10 is be VBZ cord-298525-hhcfrjrn 116 11 suppressed suppress VBN cord-298525-hhcfrjrn 116 12 by by IN cord-298525-hhcfrjrn 116 13 supranuclear supranuclear NN cord-298525-hhcfrjrn 116 14 inhibition inhibition NN cord-298525-hhcfrjrn 116 15 via via IN cord-298525-hhcfrjrn 116 16 central central JJ cord-298525-hhcfrjrn 116 17 sympathetic sympathetic JJ cord-298525-hhcfrjrn 116 18 neurons neuron NNS cord-298525-hhcfrjrn 116 19 , , , cord-298525-hhcfrjrn 116 20 resulting result VBG cord-298525-hhcfrjrn 116 21 in in IN cord-298525-hhcfrjrn 116 22 relaxation relaxation NN cord-298525-hhcfrjrn 116 23 of of IN cord-298525-hhcfrjrn 116 24 the the DT cord-298525-hhcfrjrn 116 25 muscle muscle NN cord-298525-hhcfrjrn 116 26 and and CC cord-298525-hhcfrjrn 116 27 pupil pupil NN cord-298525-hhcfrjrn 116 28 dilation dilation NN cord-298525-hhcfrjrn 116 29 . . . cord-298525-hhcfrjrn 117 1 These these DT cord-298525-hhcfrjrn 117 2 sympathetic sympathetic JJ cord-298525-hhcfrjrn 117 3 neurons neuron NNS cord-298525-hhcfrjrn 117 4 primarily primarily RB cord-298525-hhcfrjrn 117 5 originate originate VBP cord-298525-hhcfrjrn 117 6 in in IN cord-298525-hhcfrjrn 117 7 the the DT cord-298525-hhcfrjrn 117 8 reticular reticular NN cord-298525-hhcfrjrn 117 9 activating activate VBG cord-298525-hhcfrjrn 117 10 formation formation NN cord-298525-hhcfrjrn 117 11 in in IN cord-298525-hhcfrjrn 117 12 the the DT cord-298525-hhcfrjrn 117 13 brainstem brainstem NN cord-298525-hhcfrjrn 117 14 and and CC cord-298525-hhcfrjrn 117 15 inhibit inhibit VB cord-298525-hhcfrjrn 117 16 the the DT cord-298525-hhcfrjrn 117 17 pre pre JJ cord-298525-hhcfrjrn 117 18 - - JJ cord-298525-hhcfrjrn 117 19 ganglionic ganglionic JJ cord-298525-hhcfrjrn 117 20 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 117 21 neurons neuron NNS cord-298525-hhcfrjrn 117 22 at at IN cord-298525-hhcfrjrn 117 23 the the DT cord-298525-hhcfrjrn 117 24 EW EW NNP cord-298525-hhcfrjrn 117 25 nucleus nucleus NN cord-298525-hhcfrjrn 117 26 via via IN cord-298525-hhcfrjrn 117 27 α α NNP cord-298525-hhcfrjrn 117 28 2 2 CD cord-298525-hhcfrjrn 117 29 -adrenergic -adrenergic JJ cord-298525-hhcfrjrn 117 30 receptor receptor NN cord-298525-hhcfrjrn 117 31 activation activation NN cord-298525-hhcfrjrn 117 32 . . . cord-298525-hhcfrjrn 118 1 Secondly secondly RB cord-298525-hhcfrjrn 118 2 , , , cord-298525-hhcfrjrn 118 3 the the DT cord-298525-hhcfrjrn 118 4 iris iris NNP cord-298525-hhcfrjrn 118 5 dilator dilator NN cord-298525-hhcfrjrn 118 6 muscle muscle NN cord-298525-hhcfrjrn 118 7 contracts contract NNS cord-298525-hhcfrjrn 118 8 via via IN cord-298525-hhcfrjrn 118 9 excitation excitation NN cord-298525-hhcfrjrn 118 10 of of IN cord-298525-hhcfrjrn 118 11 the the DT cord-298525-hhcfrjrn 118 12 α α NN cord-298525-hhcfrjrn 118 13 1 1 CD cord-298525-hhcfrjrn 118 14 -adrenergic -adrenergic JJ cord-298525-hhcfrjrn 118 15 sympathetic sympathetic JJ cord-298525-hhcfrjrn 118 16 pathway pathway NN cord-298525-hhcfrjrn 118 17 . . . cord-298525-hhcfrjrn 119 1 This this DT cord-298525-hhcfrjrn 119 2 peripheral peripheral JJ cord-298525-hhcfrjrn 119 3 sympathetic sympathetic JJ cord-298525-hhcfrjrn 119 4 nerve nerve NN cord-298525-hhcfrjrn 119 5 activation activation NN cord-298525-hhcfrjrn 119 6 greatly greatly RB cord-298525-hhcfrjrn 119 7 enhances enhance VBZ cord-298525-hhcfrjrn 119 8 the the DT cord-298525-hhcfrjrn 119 9 dynamics dynamic NNS cord-298525-hhcfrjrn 119 10 of of IN cord-298525-hhcfrjrn 119 11 pupil pupil NN cord-298525-hhcfrjrn 119 12 dilation dilation NN cord-298525-hhcfrjrn 119 13 in in IN cord-298525-hhcfrjrn 119 14 terms term NNS cord-298525-hhcfrjrn 119 15 of of IN cord-298525-hhcfrjrn 119 16 speed speed NN cord-298525-hhcfrjrn 119 17 and and CC cord-298525-hhcfrjrn 119 18 maximal maximal JJ cord-298525-hhcfrjrn 119 19 pupil pupil NN cord-298525-hhcfrjrn 119 20 diameter diameter NN cord-298525-hhcfrjrn 119 21 attained attain VBN cord-298525-hhcfrjrn 119 22 . . . cord-298525-hhcfrjrn 120 1 The the DT cord-298525-hhcfrjrn 120 2 sympathetic sympathetic JJ cord-298525-hhcfrjrn 120 3 influence influence NN cord-298525-hhcfrjrn 120 4 on on IN cord-298525-hhcfrjrn 120 5 the the DT cord-298525-hhcfrjrn 120 6 iris iris NNP cord-298525-hhcfrjrn 120 7 dilator dilator NN cord-298525-hhcfrjrn 120 8 muscle muscle NN cord-298525-hhcfrjrn 120 9 consists consist VBZ cord-298525-hhcfrjrn 120 10 of of IN cord-298525-hhcfrjrn 120 11 a a DT cord-298525-hhcfrjrn 120 12 paired paired JJ cord-298525-hhcfrjrn 120 13 , , , cord-298525-hhcfrjrn 120 14 three three CD cord-298525-hhcfrjrn 120 15 - - HYPH cord-298525-hhcfrjrn 120 16 neuron neuron NN cord-298525-hhcfrjrn 120 17 arc arc NN cord-298525-hhcfrjrn 120 18 on on IN cord-298525-hhcfrjrn 120 19 both both CC cord-298525-hhcfrjrn 120 20 the the DT cord-298525-hhcfrjrn 120 21 right right NN cord-298525-hhcfrjrn 120 22 and and CC cord-298525-hhcfrjrn 120 23 left left JJ cord-298525-hhcfrjrn 120 24 side side NN cord-298525-hhcfrjrn 120 25 of of IN cord-298525-hhcfrjrn 120 26 the the DT cord-298525-hhcfrjrn 120 27 central central JJ cord-298525-hhcfrjrn 120 28 and and CC cord-298525-hhcfrjrn 120 29 peripheral peripheral JJ cord-298525-hhcfrjrn 120 30 nervous nervous JJ cord-298525-hhcfrjrn 120 31 system system NN cord-298525-hhcfrjrn 120 32 , , , cord-298525-hhcfrjrn 120 33 without without IN cord-298525-hhcfrjrn 120 34 decussations decussation NNS cord-298525-hhcfrjrn 120 35 , , , cord-298525-hhcfrjrn 120 36 extending extend VBG cord-298525-hhcfrjrn 120 37 from from IN cord-298525-hhcfrjrn 120 38 the the DT cord-298525-hhcfrjrn 120 39 hypothalamus hypothalamus NN cord-298525-hhcfrjrn 120 40 to to IN cord-298525-hhcfrjrn 120 41 the the DT cord-298525-hhcfrjrn 120 42 iris iris NNP cord-298525-hhcfrjrn 120 43 dilator dilator NN cord-298525-hhcfrjrn 120 44 muscle muscle NN cord-298525-hhcfrjrn 120 45 ( ( -LRB- cord-298525-hhcfrjrn 120 46 Figure figure NN cord-298525-hhcfrjrn 120 47 4 4 CD cord-298525-hhcfrjrn 120 48 ) ) -RRB- cord-298525-hhcfrjrn 121 1 [ [ -LRB- cord-298525-hhcfrjrn 121 2 43 43 CD cord-298525-hhcfrjrn 121 3 - - SYM cord-298525-hhcfrjrn 121 4 45 45 CD cord-298525-hhcfrjrn 121 5 ] ] -RRB- cord-298525-hhcfrjrn 121 6 . . . cord-298525-hhcfrjrn 122 1 In in IN cord-298525-hhcfrjrn 122 2 this this DT cord-298525-hhcfrjrn 122 3 three three CD cord-298525-hhcfrjrn 122 4 - - HYPH cord-298525-hhcfrjrn 122 5 neuron neuron NN cord-298525-hhcfrjrn 122 6 arc arc NN cord-298525-hhcfrjrn 122 7 , , , cord-298525-hhcfrjrn 122 8 the the DT cord-298525-hhcfrjrn 122 9 synaptic synaptic JJ cord-298525-hhcfrjrn 122 10 transmission transmission NN cord-298525-hhcfrjrn 122 11 is be VBZ cord-298525-hhcfrjrn 122 12 mediated mediate VBN cord-298525-hhcfrjrn 122 13 by by IN cord-298525-hhcfrjrn 122 14 ACh ACh NNP cord-298525-hhcfrjrn 122 15 at at IN cord-298525-hhcfrjrn 122 16 the the DT cord-298525-hhcfrjrn 122 17 first first JJ cord-298525-hhcfrjrn 122 18 two two CD cord-298525-hhcfrjrn 122 19 junctions junction NNS cord-298525-hhcfrjrn 122 20 , , , cord-298525-hhcfrjrn 122 21 while while IN cord-298525-hhcfrjrn 122 22 the the DT cord-298525-hhcfrjrn 122 23 post post JJ cord-298525-hhcfrjrn 122 24 - - JJ cord-298525-hhcfrjrn 122 25 ganglionic ganglionic JJ cord-298525-hhcfrjrn 122 26 fibres fibre NNS cord-298525-hhcfrjrn 122 27 innervate innervate VBP cord-298525-hhcfrjrn 122 28 the the DT cord-298525-hhcfrjrn 122 29 dilator dilator NN cord-298525-hhcfrjrn 122 30 muscle muscle NN cord-298525-hhcfrjrn 122 31 via via IN cord-298525-hhcfrjrn 122 32 noradrenaline noradrenaline NN cord-298525-hhcfrjrn 122 33 . . . cord-298525-hhcfrjrn 123 1 Nerves nerve NNS cord-298525-hhcfrjrn 123 2 within within IN cord-298525-hhcfrjrn 123 3 the the DT cord-298525-hhcfrjrn 123 4 ophthalmic ophthalmic JJ cord-298525-hhcfrjrn 123 5 division division NN cord-298525-hhcfrjrn 123 6 of of IN cord-298525-hhcfrjrn 123 7 the the DT cord-298525-hhcfrjrn 123 8 trigeminal trigeminal JJ cord-298525-hhcfrjrn 123 9 nerve nerve NN cord-298525-hhcfrjrn 123 10 provide provide VBP cord-298525-hhcfrjrn 123 11 sensory sensory JJ cord-298525-hhcfrjrn 123 12 innervation innervation NN cord-298525-hhcfrjrn 123 13 to to IN cord-298525-hhcfrjrn 123 14 the the DT cord-298525-hhcfrjrn 123 15 iris iris NN cord-298525-hhcfrjrn 123 16 and and CC cord-298525-hhcfrjrn 123 17 may may MD cord-298525-hhcfrjrn 123 18 play play VB cord-298525-hhcfrjrn 123 19 an an DT cord-298525-hhcfrjrn 123 20 additional additional JJ cord-298525-hhcfrjrn 123 21 role role NN cord-298525-hhcfrjrn 123 22 in in IN cord-298525-hhcfrjrn 123 23 modulating modulate VBG cord-298525-hhcfrjrn 123 24 pupil pupil NN cord-298525-hhcfrjrn 123 25 diameter diameter NN cord-298525-hhcfrjrn 123 26 [ [ -LRB- cord-298525-hhcfrjrn 123 27 46 46 CD cord-298525-hhcfrjrn 123 28 ] ] -RRB- cord-298525-hhcfrjrn 123 29 . . . cord-298525-hhcfrjrn 124 1 Mechanical mechanical JJ cord-298525-hhcfrjrn 124 2 and and CC cord-298525-hhcfrjrn 124 3 chemical chemical JJ cord-298525-hhcfrjrn 124 4 irritation irritation NN cord-298525-hhcfrjrn 124 5 of of IN cord-298525-hhcfrjrn 124 6 the the DT cord-298525-hhcfrjrn 124 7 eye eye NN cord-298525-hhcfrjrn 124 8 can can MD cord-298525-hhcfrjrn 124 9 cause cause VB cord-298525-hhcfrjrn 124 10 a a DT cord-298525-hhcfrjrn 124 11 strong strong JJ cord-298525-hhcfrjrn 124 12 miotic miotic JJ cord-298525-hhcfrjrn 124 13 response response NN cord-298525-hhcfrjrn 124 14 that that WDT cord-298525-hhcfrjrn 124 15 is be VBZ cord-298525-hhcfrjrn 124 16 non non JJ cord-298525-hhcfrjrn 124 17 - - JJ cord-298525-hhcfrjrn 124 18 cholinergic cholinergic JJ cord-298525-hhcfrjrn 124 19 and and CC cord-298525-hhcfrjrn 124 20 fails fail VBZ cord-298525-hhcfrjrn 124 21 to to TO cord-298525-hhcfrjrn 124 22 reverse reverse VB cord-298525-hhcfrjrn 124 23 with with IN cord-298525-hhcfrjrn 124 24 autonomic autonomic JJ cord-298525-hhcfrjrn 124 25 - - HYPH cord-298525-hhcfrjrn 124 26 acting act VBG cord-298525-hhcfrjrn 124 27 drugs drug NNS cord-298525-hhcfrjrn 124 28 . . . cord-298525-hhcfrjrn 125 1 In in IN cord-298525-hhcfrjrn 125 2 addition addition NN cord-298525-hhcfrjrn 125 3 to to IN cord-298525-hhcfrjrn 125 4 the the DT cord-298525-hhcfrjrn 125 5 neuronal neuronal JJ cord-298525-hhcfrjrn 125 6 mechanisms mechanism NNS cord-298525-hhcfrjrn 125 7 involved involve VBN cord-298525-hhcfrjrn 125 8 in in IN cord-298525-hhcfrjrn 125 9 pupil pupil NN cord-298525-hhcfrjrn 125 10 size size NN cord-298525-hhcfrjrn 125 11 control control NN cord-298525-hhcfrjrn 125 12 , , , cord-298525-hhcfrjrn 125 13 circulating circulate VBG cord-298525-hhcfrjrn 125 14 catecholamines catecholamine NNS cord-298525-hhcfrjrn 125 15 and and CC cord-298525-hhcfrjrn 125 16 peptide peptide JJ cord-298525-hhcfrjrn 125 17 hormones hormone NNS cord-298525-hhcfrjrn 125 18 may may MD cord-298525-hhcfrjrn 125 19 act act VB cord-298525-hhcfrjrn 125 20 on on IN cord-298525-hhcfrjrn 125 21 the the DT cord-298525-hhcfrjrn 125 22 iris iris NNP cord-298525-hhcfrjrn 125 23 dilator dilator NN cord-298525-hhcfrjrn 125 24 or or CC cord-298525-hhcfrjrn 125 25 sphincter sphincter NN cord-298525-hhcfrjrn 125 26 muscles muscle NNS cord-298525-hhcfrjrn 125 27 , , , cord-298525-hhcfrjrn 125 28 either either CC cord-298525-hhcfrjrn 125 29 directly directly RB cord-298525-hhcfrjrn 125 30 through through IN cord-298525-hhcfrjrn 125 31 the the DT cord-298525-hhcfrjrn 125 32 bloodstream bloodstream NN cord-298525-hhcfrjrn 125 33 or or CC cord-298525-hhcfrjrn 125 34 potentially potentially RB cord-298525-hhcfrjrn 125 35 indirectly indirectly RB cord-298525-hhcfrjrn 125 36 through through IN cord-298525-hhcfrjrn 125 37 the the DT cord-298525-hhcfrjrn 125 38 tears tear NNS cord-298525-hhcfrjrn 125 39 [ [ -LRB- cord-298525-hhcfrjrn 125 40 47,48 47,48 CD cord-298525-hhcfrjrn 125 41 ] ] -RRB- cord-298525-hhcfrjrn 125 42 . . . cord-298525-hhcfrjrn 125 43 _SP cord-298525-hhcfrjrn 126 1 Conditions condition NNS cord-298525-hhcfrjrn 126 2 that that WDT cord-298525-hhcfrjrn 126 3 influence influence VBP cord-298525-hhcfrjrn 126 4 the the DT cord-298525-hhcfrjrn 126 5 integration integration NN cord-298525-hhcfrjrn 126 6 of of IN cord-298525-hhcfrjrn 126 7 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 126 8 stimulation stimulation NN cord-298525-hhcfrjrn 126 9 and and CC cord-298525-hhcfrjrn 126 10 inhibition inhibition NN cord-298525-hhcfrjrn 126 11 , , , cord-298525-hhcfrjrn 126 12 sympathetic sympathetic JJ cord-298525-hhcfrjrn 126 13 stimulation stimulation NN cord-298525-hhcfrjrn 126 14 and and CC cord-298525-hhcfrjrn 126 15 humoural humoural JJ cord-298525-hhcfrjrn 126 16 release release NN cord-298525-hhcfrjrn 126 17 of of IN cord-298525-hhcfrjrn 126 18 neurotransmitters neurotransmitter NNS cord-298525-hhcfrjrn 126 19 may may MD cord-298525-hhcfrjrn 126 20 each each DT cord-298525-hhcfrjrn 126 21 affect affect VB cord-298525-hhcfrjrn 126 22 the the DT cord-298525-hhcfrjrn 126 23 dynamics dynamic NNS cord-298525-hhcfrjrn 126 24 of of IN cord-298525-hhcfrjrn 126 25 the the DT cord-298525-hhcfrjrn 126 26 PLR plr NN cord-298525-hhcfrjrn 126 27 and and CC cord-298525-hhcfrjrn 126 28 may may MD cord-298525-hhcfrjrn 126 29 be be VB cord-298525-hhcfrjrn 126 30 clinically clinically RB cord-298525-hhcfrjrn 126 31 diagnostic diagnostic JJ cord-298525-hhcfrjrn 126 32 . . . cord-298525-hhcfrjrn 127 1 Pupil pupil NN cord-298525-hhcfrjrn 127 2 [ [ -LRB- cord-298525-hhcfrjrn 127 3 57 57 CD cord-298525-hhcfrjrn 127 4 ] ] -RRB- cord-298525-hhcfrjrn 127 5 [ [ -LRB- cord-298525-hhcfrjrn 127 6 58 58 CD cord-298525-hhcfrjrn 127 7 ] ] -RRB- cord-298525-hhcfrjrn 127 8 [ [ -LRB- cord-298525-hhcfrjrn 127 9 59 59 CD cord-298525-hhcfrjrn 127 10 ] ] -RRB- cord-298525-hhcfrjrn 128 1 [ [ -LRB- cord-298525-hhcfrjrn 128 2 60 60 CD cord-298525-hhcfrjrn 128 3 ] ] -RRB- cord-298525-hhcfrjrn 128 4 diseases disease NNS cord-298525-hhcfrjrn 128 5 , , , cord-298525-hhcfrjrn 128 6 autism autism NN cord-298525-hhcfrjrn 128 7 spectrum spectrum NN cord-298525-hhcfrjrn 128 8 disorders disorder NNS cord-298525-hhcfrjrn 128 9 [ [ -LRB- cord-298525-hhcfrjrn 128 10 61 61 CD cord-298525-hhcfrjrn 128 11 , , , cord-298525-hhcfrjrn 128 12 62 62 CD cord-298525-hhcfrjrn 128 13 ] ] -RRB- cord-298525-hhcfrjrn 128 14 , , , cord-298525-hhcfrjrn 128 15 as as RB cord-298525-hhcfrjrn 128 16 well well RB cord-298525-hhcfrjrn 128 17 as as IN cord-298525-hhcfrjrn 128 18 glaucoma glaucoma NN cord-298525-hhcfrjrn 128 19 [ [ -LRB- cord-298525-hhcfrjrn 128 20 14 14 CD cord-298525-hhcfrjrn 128 21 , , , cord-298525-hhcfrjrn 128 22 [ [ -LRB- cord-298525-hhcfrjrn 128 23 63 63 CD cord-298525-hhcfrjrn 128 24 ] ] -RRB- cord-298525-hhcfrjrn 128 25 [ [ -LRB- cord-298525-hhcfrjrn 128 26 64 64 CD cord-298525-hhcfrjrn 128 27 ] ] -RRB- cord-298525-hhcfrjrn 128 28 [ [ -LRB- cord-298525-hhcfrjrn 128 29 65 65 CD cord-298525-hhcfrjrn 128 30 ] ] -RRB- cord-298525-hhcfrjrn 128 31 and and CC cord-298525-hhcfrjrn 128 32 autonomic autonomic JJ cord-298525-hhcfrjrn 128 33 neuropathies neuropathy NNS cord-298525-hhcfrjrn 128 34 associated associate VBN cord-298525-hhcfrjrn 128 35 with with IN cord-298525-hhcfrjrn 128 36 diabetes diabete NNS cord-298525-hhcfrjrn 128 37 [ [ -LRB- cord-298525-hhcfrjrn 128 38 66 66 CD cord-298525-hhcfrjrn 128 39 ] ] -RRB- cord-298525-hhcfrjrn 128 40 [ [ -LRB- cord-298525-hhcfrjrn 128 41 67 67 CD cord-298525-hhcfrjrn 128 42 ] ] -RRB- cord-298525-hhcfrjrn 128 43 [ [ -LRB- cord-298525-hhcfrjrn 128 44 68 68 CD cord-298525-hhcfrjrn 128 45 ] ] -RRB- cord-298525-hhcfrjrn 128 46 [ [ -LRB- cord-298525-hhcfrjrn 128 47 69 69 CD cord-298525-hhcfrjrn 128 48 ] ] -RRB- cord-298525-hhcfrjrn 128 49 [ [ -LRB- cord-298525-hhcfrjrn 128 50 70 70 CD cord-298525-hhcfrjrn 128 51 ] ] -RRB- cord-298525-hhcfrjrn 128 52 . . . cord-298525-hhcfrjrn 129 1 Additionally additionally RB cord-298525-hhcfrjrn 129 2 , , , cord-298525-hhcfrjrn 129 3 pupillometry pupillometry NNP cord-298525-hhcfrjrn 129 4 has have VBZ cord-298525-hhcfrjrn 129 5 been be VBN cord-298525-hhcfrjrn 129 6 applied apply VBN cord-298525-hhcfrjrn 129 7 to to IN cord-298525-hhcfrjrn 129 8 other other JJ cord-298525-hhcfrjrn 129 9 clinical clinical JJ cord-298525-hhcfrjrn 129 10 fields field NNS cord-298525-hhcfrjrn 129 11 , , , cord-298525-hhcfrjrn 129 12 such such JJ cord-298525-hhcfrjrn 129 13 as as IN cord-298525-hhcfrjrn 129 14 monitoring monitoring NN cord-298525-hhcfrjrn 129 15 of of IN cord-298525-hhcfrjrn 129 16 central central JJ cord-298525-hhcfrjrn 129 17 states state NNS cord-298525-hhcfrjrn 129 18 in in IN cord-298525-hhcfrjrn 129 19 anaesthesiology anaesthesiology NN cord-298525-hhcfrjrn 129 20 and and CC cord-298525-hhcfrjrn 129 21 analgesia analgesia NN cord-298525-hhcfrjrn 129 22 , , , cord-298525-hhcfrjrn 129 23 as as RB cord-298525-hhcfrjrn 129 24 well well RB cord-298525-hhcfrjrn 129 25 as as IN cord-298525-hhcfrjrn 129 26 monitoring monitoring NN cord-298525-hhcfrjrn 129 27 and and CC cord-298525-hhcfrjrn 129 28 prognosis prognosis NN cord-298525-hhcfrjrn 129 29 following follow VBG cord-298525-hhcfrjrn 129 30 head head NN cord-298525-hhcfrjrn 129 31 injuries injury NNS cord-298525-hhcfrjrn 129 32 , , , cord-298525-hhcfrjrn 129 33 cardiac cardiac JJ cord-298525-hhcfrjrn 129 34 arrest arrest NN cord-298525-hhcfrjrn 129 35 and and CC cord-298525-hhcfrjrn 129 36 drug drug NN cord-298525-hhcfrjrn 129 37 overdose overdose NN cord-298525-hhcfrjrn 129 38 [ [ -LRB- cord-298525-hhcfrjrn 129 39 71 71 CD cord-298525-hhcfrjrn 129 40 ] ] -RRB- cord-298525-hhcfrjrn 129 41 . . . cord-298525-hhcfrjrn 130 1 There there EX cord-298525-hhcfrjrn 130 2 is be VBZ cord-298525-hhcfrjrn 130 3 an an DT cord-298525-hhcfrjrn 130 4 established establish VBN cord-298525-hhcfrjrn 130 5 body body NN cord-298525-hhcfrjrn 130 6 of of IN cord-298525-hhcfrjrn 130 7 evidence evidence NN cord-298525-hhcfrjrn 130 8 to to TO cord-298525-hhcfrjrn 130 9 indicate indicate VB cord-298525-hhcfrjrn 130 10 that that IN cord-298525-hhcfrjrn 130 11 cholinergic cholinergic JJ cord-298525-hhcfrjrn 130 12 hypofunction hypofunction NN cord-298525-hhcfrjrn 130 13 is be VBZ cord-298525-hhcfrjrn 130 14 a a DT cord-298525-hhcfrjrn 130 15 significant significant JJ cord-298525-hhcfrjrn 130 16 component component NN cord-298525-hhcfrjrn 130 17 of of IN cord-298525-hhcfrjrn 130 18 neurodegenerative neurodegenerative JJ cord-298525-hhcfrjrn 130 19 diseases disease NNS cord-298525-hhcfrjrn 130 20 , , , cord-298525-hhcfrjrn 130 21 such such JJ cord-298525-hhcfrjrn 130 22 as as IN cord-298525-hhcfrjrn 130 23 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 130 24 's 's POS cord-298525-hhcfrjrn 130 25 and and CC cord-298525-hhcfrjrn 130 26 Parkinson Parkinson NNP cord-298525-hhcfrjrn 130 27 's 's POS cord-298525-hhcfrjrn 130 28 diseases disease NNS cord-298525-hhcfrjrn 130 29 , , , cord-298525-hhcfrjrn 130 30 which which WDT cord-298525-hhcfrjrn 130 31 are be VBP cord-298525-hhcfrjrn 130 32 due due JJ cord-298525-hhcfrjrn 130 33 to to IN cord-298525-hhcfrjrn 130 34 ACh ACh NNP cord-298525-hhcfrjrn 130 35 and and CC cord-298525-hhcfrjrn 130 36 dopamine dopamine NN cord-298525-hhcfrjrn 130 37 deficiencies deficiency NNS cord-298525-hhcfrjrn 130 38 , , , cord-298525-hhcfrjrn 130 39 respectively respectively RB cord-298525-hhcfrjrn 130 40 . . . cord-298525-hhcfrjrn 131 1 Moreover moreover RB cord-298525-hhcfrjrn 131 2 , , , cord-298525-hhcfrjrn 131 3 the the DT cord-298525-hhcfrjrn 131 4 majority majority NN cord-298525-hhcfrjrn 131 5 of of IN cord-298525-hhcfrjrn 131 6 studies study NNS cord-298525-hhcfrjrn 131 7 that that WDT cord-298525-hhcfrjrn 131 8 analysed analyse VBD cord-298525-hhcfrjrn 131 9 ACh ACh NNP cord-298525-hhcfrjrn 131 10 - - HYPH cord-298525-hhcfrjrn 131 11 dependent dependent JJ cord-298525-hhcfrjrn 131 12 PLR plr NN cord-298525-hhcfrjrn 131 13 parameters parameter NNS cord-298525-hhcfrjrn 131 14 have have VBP cord-298525-hhcfrjrn 131 15 revealed reveal VBN cord-298525-hhcfrjrn 131 16 significant significant JJ cord-298525-hhcfrjrn 131 17 differences difference NNS cord-298525-hhcfrjrn 131 18 between between IN cord-298525-hhcfrjrn 131 19 normal normal JJ cord-298525-hhcfrjrn 131 20 age age NN cord-298525-hhcfrjrn 131 21 - - HYPH cord-298525-hhcfrjrn 131 22 matched match VBN cord-298525-hhcfrjrn 131 23 patients patient NNS cord-298525-hhcfrjrn 131 24 and and CC cord-298525-hhcfrjrn 131 25 those those DT cord-298525-hhcfrjrn 131 26 with with IN cord-298525-hhcfrjrn 131 27 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 131 28 's 's POS cord-298525-hhcfrjrn 131 29 [ [ -LRB- cord-298525-hhcfrjrn 131 30 55 55 CD cord-298525-hhcfrjrn 131 31 - - SYM cord-298525-hhcfrjrn 131 32 57 57 CD cord-298525-hhcfrjrn 131 33 , , , cord-298525-hhcfrjrn 131 34 [ [ -LRB- cord-298525-hhcfrjrn 131 35 72 72 CD cord-298525-hhcfrjrn 131 36 ] ] -RRB- cord-298525-hhcfrjrn 131 37 [ [ -LRB- cord-298525-hhcfrjrn 131 38 73 73 CD cord-298525-hhcfrjrn 131 39 ] ] -RRB- cord-298525-hhcfrjrn 131 40 [ [ -LRB- cord-298525-hhcfrjrn 131 41 74 74 CD cord-298525-hhcfrjrn 131 42 ] ] -RRB- cord-298525-hhcfrjrn 131 43 or or CC cord-298525-hhcfrjrn 131 44 Parkinson Parkinson NNP cord-298525-hhcfrjrn 131 45 's 's POS cord-298525-hhcfrjrn 131 46 disease disease NN cord-298525-hhcfrjrn 131 47 [ [ -LRB- cord-298525-hhcfrjrn 131 48 58 58 CD cord-298525-hhcfrjrn 131 49 , , , cord-298525-hhcfrjrn 131 50 59 59 CD cord-298525-hhcfrjrn 131 51 , , , cord-298525-hhcfrjrn 131 52 75 75 CD cord-298525-hhcfrjrn 131 53 ] ] -RRB- cord-298525-hhcfrjrn 131 54 . . . cord-298525-hhcfrjrn 132 1 Studies study NNS cord-298525-hhcfrjrn 132 2 typically typically RB cord-298525-hhcfrjrn 132 3 used use VBD cord-298525-hhcfrjrn 132 4 light light JJ cord-298525-hhcfrjrn 132 5 stimuli stimulus NNS cord-298525-hhcfrjrn 132 6 wavelength wavelength NN cord-298525-hhcfrjrn 132 7 of of IN cord-298525-hhcfrjrn 132 8 820 820 CD cord-298525-hhcfrjrn 132 9 nm nm NN cord-298525-hhcfrjrn 132 10 with with IN cord-298525-hhcfrjrn 132 11 a a DT cord-298525-hhcfrjrn 132 12 light light JJ cord-298525-hhcfrjrn 132 13 intensity intensity NN cord-298525-hhcfrjrn 132 14 of of IN cord-298525-hhcfrjrn 132 15 24.6 24.6 CD cord-298525-hhcfrjrn 132 16 cd cd NNP cord-298525-hhcfrjrn 132 17 / / SYM cord-298525-hhcfrjrn 132 18 m m NN cord-298525-hhcfrjrn 132 19 2 2 CD cord-298525-hhcfrjrn 132 20 . . . cord-298525-hhcfrjrn 133 1 Specifically specifically RB cord-298525-hhcfrjrn 133 2 , , , cord-298525-hhcfrjrn 133 3 patients patient NNS cord-298525-hhcfrjrn 133 4 with with IN cord-298525-hhcfrjrn 133 5 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 133 6 's 's POS cord-298525-hhcfrjrn 133 7 [ [ -LRB- cord-298525-hhcfrjrn 133 8 57 57 CD cord-298525-hhcfrjrn 133 9 ] ] -RRB- cord-298525-hhcfrjrn 133 10 or or CC cord-298525-hhcfrjrn 133 11 Parkinson Parkinson NNP cord-298525-hhcfrjrn 133 12 's 's POS cord-298525-hhcfrjrn 133 13 disease disease NN cord-298525-hhcfrjrn 133 14 , , , cord-298525-hhcfrjrn 133 15 with with IN cord-298525-hhcfrjrn 133 16 or or CC cord-298525-hhcfrjrn 133 17 without without IN cord-298525-hhcfrjrn 133 18 any any DT cord-298525-hhcfrjrn 133 19 detectable detectable JJ cord-298525-hhcfrjrn 133 20 cognitive cognitive JJ cord-298525-hhcfrjrn 133 21 deficits deficit NNS cord-298525-hhcfrjrn 133 22 or or CC cord-298525-hhcfrjrn 133 23 psychiatric psychiatric JJ cord-298525-hhcfrjrn 133 24 disorders disorder NNS cord-298525-hhcfrjrn 133 25 [ [ -LRB- cord-298525-hhcfrjrn 133 26 55 55 CD cord-298525-hhcfrjrn 133 27 , , , cord-298525-hhcfrjrn 133 28 57 57 CD cord-298525-hhcfrjrn 133 29 , , , cord-298525-hhcfrjrn 133 30 75 75 CD cord-298525-hhcfrjrn 133 31 ] ] -RRB- cord-298525-hhcfrjrn 133 32 , , , cord-298525-hhcfrjrn 133 33 had have VBD cord-298525-hhcfrjrn 133 34 significantly significantly RB cord-298525-hhcfrjrn 133 35 lower low JJR cord-298525-hhcfrjrn 133 36 MCV MCV NNP cord-298525-hhcfrjrn 133 37 and and CC cord-298525-hhcfrjrn 133 38 MCA MCA NNP cord-298525-hhcfrjrn 133 39 values value NNS cord-298525-hhcfrjrn 133 40 . . . cord-298525-hhcfrjrn 134 1 Ferrario Ferrario NNP cord-298525-hhcfrjrn 134 2 et et FW cord-298525-hhcfrjrn 134 3 al al NNP cord-298525-hhcfrjrn 134 4 . . . cord-298525-hhcfrjrn 135 1 [ [ -LRB- cord-298525-hhcfrjrn 135 2 76 76 CD cord-298525-hhcfrjrn 135 3 ] ] -RRB- cord-298525-hhcfrjrn 135 4 did do VBD cord-298525-hhcfrjrn 135 5 not not RB cord-298525-hhcfrjrn 135 6 observe observe VB cord-298525-hhcfrjrn 135 7 a a DT cord-298525-hhcfrjrn 135 8 significant significant JJ cord-298525-hhcfrjrn 135 9 difference difference NN cord-298525-hhcfrjrn 135 10 in in IN cord-298525-hhcfrjrn 135 11 MCA MCA NNP cord-298525-hhcfrjrn 135 12 between between IN cord-298525-hhcfrjrn 135 13 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 135 14 's 's POS cord-298525-hhcfrjrn 135 15 patients patient NNS cord-298525-hhcfrjrn 135 16 and and CC cord-298525-hhcfrjrn 135 17 controls control NNS cord-298525-hhcfrjrn 135 18 ; ; : cord-298525-hhcfrjrn 135 19 however however RB cord-298525-hhcfrjrn 135 20 , , , cord-298525-hhcfrjrn 135 21 this this DT cord-298525-hhcfrjrn 135 22 may may MD cord-298525-hhcfrjrn 135 23 be be VB cord-298525-hhcfrjrn 135 24 attributed attribute VBN cord-298525-hhcfrjrn 135 25 to to IN cord-298525-hhcfrjrn 135 26 the the DT cord-298525-hhcfrjrn 135 27 longer long JJR cord-298525-hhcfrjrn 135 28 light light JJ cord-298525-hhcfrjrn 135 29 stimulus stimulus NN cord-298525-hhcfrjrn 135 30 used use VBN cord-298525-hhcfrjrn 135 31 ( ( -LRB- cord-298525-hhcfrjrn 135 32 1 1 CD cord-298525-hhcfrjrn 135 33 s s NN cord-298525-hhcfrjrn 135 34 ) ) -RRB- cord-298525-hhcfrjrn 135 35 compared compare VBN cord-298525-hhcfrjrn 135 36 to to IN cord-298525-hhcfrjrn 135 37 the the DT cord-298525-hhcfrjrn 135 38 other other JJ cord-298525-hhcfrjrn 135 39 studies study NNS cord-298525-hhcfrjrn 135 40 ( ( -LRB- cord-298525-hhcfrjrn 135 41 20 20 CD cord-298525-hhcfrjrn 135 42 - - SYM cord-298525-hhcfrjrn 135 43 150 150 CD cord-298525-hhcfrjrn 135 44 ms m NNS cord-298525-hhcfrjrn 135 45 ) ) -RRB- cord-298525-hhcfrjrn 135 46 [ [ -LRB- cord-298525-hhcfrjrn 135 47 77 77 CD cord-298525-hhcfrjrn 135 48 ] ] -RRB- cord-298525-hhcfrjrn 135 49 . . . cord-298525-hhcfrjrn 136 1 The the DT cord-298525-hhcfrjrn 136 2 MCV MCV NNP cord-298525-hhcfrjrn 136 3 and and CC cord-298525-hhcfrjrn 136 4 MCA MCA NNP cord-298525-hhcfrjrn 136 5 parameters parameter NNS cord-298525-hhcfrjrn 136 6 correspond correspond VBP cord-298525-hhcfrjrn 136 7 to to IN cord-298525-hhcfrjrn 136 8 the the DT cord-298525-hhcfrjrn 136 9 first first JJ cord-298525-hhcfrjrn 136 10 portion portion NN cord-298525-hhcfrjrn 136 11 of of IN cord-298525-hhcfrjrn 136 12 the the DT cord-298525-hhcfrjrn 136 13 characteristic characteristic JJ cord-298525-hhcfrjrn 136 14 V v NN cord-298525-hhcfrjrn 136 15 - - HYPH cord-298525-hhcfrjrn 136 16 shaped shape VBN cord-298525-hhcfrjrn 136 17 pupillometric pupillometric JJ cord-298525-hhcfrjrn 136 18 response response NN cord-298525-hhcfrjrn 136 19 ( ( -LRB- cord-298525-hhcfrjrn 136 20 Figure figure NN cord-298525-hhcfrjrn 136 21 4 4 CD cord-298525-hhcfrjrn 136 22 ) ) -RRB- cord-298525-hhcfrjrn 136 23 and and CC cord-298525-hhcfrjrn 136 24 are be VBP cord-298525-hhcfrjrn 136 25 considered consider VBN cord-298525-hhcfrjrn 136 26 the the DT cord-298525-hhcfrjrn 136 27 most most RBS cord-298525-hhcfrjrn 136 28 sensitive sensitive JJ cord-298525-hhcfrjrn 136 29 markers marker NNS cord-298525-hhcfrjrn 136 30 of of IN cord-298525-hhcfrjrn 136 31 cholinergic cholinergic JJ cord-298525-hhcfrjrn 136 32 activity activity NN cord-298525-hhcfrjrn 136 33 [ [ -LRB- cord-298525-hhcfrjrn 136 34 78 78 CD cord-298525-hhcfrjrn 136 35 ] ] -RRB- cord-298525-hhcfrjrn 136 36 . . . cord-298525-hhcfrjrn 137 1 Therefore therefore RB cord-298525-hhcfrjrn 137 2 , , , cord-298525-hhcfrjrn 137 3 the the DT cord-298525-hhcfrjrn 137 4 MCA MCA NNP cord-298525-hhcfrjrn 137 5 and and CC cord-298525-hhcfrjrn 137 6 secondarily secondarily RB cord-298525-hhcfrjrn 137 7 the the DT cord-298525-hhcfrjrn 137 8 MCV MCV NNP cord-298525-hhcfrjrn 137 9 are be VBP cord-298525-hhcfrjrn 137 10 the the DT cord-298525-hhcfrjrn 137 11 best good JJS cord-298525-hhcfrjrn 137 12 PLR plr NN cord-298525-hhcfrjrn 137 13 predictors predictor NNS cord-298525-hhcfrjrn 137 14 to to TO cord-298525-hhcfrjrn 137 15 discriminate discriminate VB cord-298525-hhcfrjrn 137 16 between between IN cord-298525-hhcfrjrn 137 17 healthy healthy JJ cord-298525-hhcfrjrn 137 18 individuals individual NNS cord-298525-hhcfrjrn 137 19 and and CC cord-298525-hhcfrjrn 137 20 patients patient NNS cord-298525-hhcfrjrn 137 21 with with IN cord-298525-hhcfrjrn 137 22 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 137 23 's 's POS cord-298525-hhcfrjrn 137 24 or or CC cord-298525-hhcfrjrn 137 25 Parkinson Parkinson NNP cord-298525-hhcfrjrn 137 26 's 's POS cord-298525-hhcfrjrn 137 27 disease disease NN cord-298525-hhcfrjrn 137 28 [ [ -LRB- cord-298525-hhcfrjrn 137 29 57 57 CD cord-298525-hhcfrjrn 137 30 , , , cord-298525-hhcfrjrn 137 31 72 72 CD cord-298525-hhcfrjrn 137 32 ] ] -RRB- cord-298525-hhcfrjrn 137 33 . . . cord-298525-hhcfrjrn 138 1 A a DT cord-298525-hhcfrjrn 138 2 significant significant JJ cord-298525-hhcfrjrn 138 3 increase increase NN cord-298525-hhcfrjrn 138 4 in in IN cord-298525-hhcfrjrn 138 5 latency latency NN cord-298525-hhcfrjrn 138 6 has have VBZ cord-298525-hhcfrjrn 138 7 been be VBN cord-298525-hhcfrjrn 138 8 observed observe VBN cord-298525-hhcfrjrn 138 9 for for IN cord-298525-hhcfrjrn 138 10 subjects subject NNS cord-298525-hhcfrjrn 138 11 with with IN cord-298525-hhcfrjrn 138 12 Parkinson Parkinson NNP cord-298525-hhcfrjrn 138 13 's 's POS cord-298525-hhcfrjrn 138 14 disease disease NN cord-298525-hhcfrjrn 138 15 [ [ -LRB- cord-298525-hhcfrjrn 138 16 57 57 CD cord-298525-hhcfrjrn 138 17 ] ] -RRB- cord-298525-hhcfrjrn 138 18 [ [ -LRB- cord-298525-hhcfrjrn 138 19 58 58 CD cord-298525-hhcfrjrn 138 20 ] ] -RRB- cord-298525-hhcfrjrn 138 21 [ [ -LRB- cord-298525-hhcfrjrn 138 22 59 59 CD cord-298525-hhcfrjrn 138 23 ] ] -RRB- cord-298525-hhcfrjrn 138 24 ; ; : cord-298525-hhcfrjrn 138 25 however however RB cord-298525-hhcfrjrn 138 26 , , , cord-298525-hhcfrjrn 138 27 this this DT cord-298525-hhcfrjrn 138 28 was be VBD cord-298525-hhcfrjrn 138 29 not not RB cord-298525-hhcfrjrn 138 30 observed observe VBN cord-298525-hhcfrjrn 138 31 consistently consistently RB cord-298525-hhcfrjrn 138 32 in in IN cord-298525-hhcfrjrn 138 33 those those DT cord-298525-hhcfrjrn 138 34 with with IN cord-298525-hhcfrjrn 138 35 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 138 36 's 's POS cord-298525-hhcfrjrn 138 37 disease disease NN cord-298525-hhcfrjrn 138 38 [ [ -LRB- cord-298525-hhcfrjrn 138 39 54 54 CD cord-298525-hhcfrjrn 138 40 , , , cord-298525-hhcfrjrn 138 41 56 56 CD cord-298525-hhcfrjrn 138 42 , , , cord-298525-hhcfrjrn 138 43 72 72 CD cord-298525-hhcfrjrn 138 44 ] ] -RRB- cord-298525-hhcfrjrn 138 45 . . . cord-298525-hhcfrjrn 139 1 Additionally additionally RB cord-298525-hhcfrjrn 139 2 , , , cord-298525-hhcfrjrn 139 3 Bittner Bittner NNP cord-298525-hhcfrjrn 139 4 et et NNP cord-298525-hhcfrjrn 139 5 al al NNP cord-298525-hhcfrjrn 139 6 . . NNP cord-298525-hhcfrjrn 139 7 examined examine VBD cord-298525-hhcfrjrn 139 8 the the DT cord-298525-hhcfrjrn 139 9 pupil pupil NN cord-298525-hhcfrjrn 139 10 's 's POS cord-298525-hhcfrjrn 139 11 response response NN cord-298525-hhcfrjrn 139 12 under under IN cord-298525-hhcfrjrn 139 13 repetitive repetitive JJ cord-298525-hhcfrjrn 139 14 light light JJ cord-298525-hhcfrjrn 139 15 stimulation stimulation NN cord-298525-hhcfrjrn 139 16 , , , cord-298525-hhcfrjrn 139 17 which which WDT cord-298525-hhcfrjrn 139 18 is be VBZ cord-298525-hhcfrjrn 139 19 systematically systematically RB cord-298525-hhcfrjrn 139 20 unstable unstable JJ cord-298525-hhcfrjrn 139 21 in in IN cord-298525-hhcfrjrn 139 22 normal normal JJ cord-298525-hhcfrjrn 139 23 patients patient NNS cord-298525-hhcfrjrn 139 24 [ [ -LRB- cord-298525-hhcfrjrn 139 25 54 54 CD cord-298525-hhcfrjrn 139 26 ] ] -RRB- cord-298525-hhcfrjrn 139 27 . . . cord-298525-hhcfrjrn 140 1 However however RB cord-298525-hhcfrjrn 140 2 , , , cord-298525-hhcfrjrn 140 3 these these DT cord-298525-hhcfrjrn 140 4 changes change NNS cord-298525-hhcfrjrn 140 5 were be VBD cord-298525-hhcfrjrn 140 6 not not RB cord-298525-hhcfrjrn 140 7 observed observe VBN cord-298525-hhcfrjrn 140 8 in in IN cord-298525-hhcfrjrn 140 9 patients patient NNS cord-298525-hhcfrjrn 140 10 with with IN cord-298525-hhcfrjrn 140 11 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 140 12 's 's POS cord-298525-hhcfrjrn 140 13 disease disease NN cord-298525-hhcfrjrn 140 14 . . . cord-298525-hhcfrjrn 141 1 A a DT cord-298525-hhcfrjrn 141 2 number number NN cord-298525-hhcfrjrn 141 3 of of IN cord-298525-hhcfrjrn 141 4 possible possible JJ cord-298525-hhcfrjrn 141 5 pathophysiological pathophysiological JJ cord-298525-hhcfrjrn 141 6 mechanisms mechanism NNS cord-298525-hhcfrjrn 141 7 have have VBP cord-298525-hhcfrjrn 141 8 been be VBN cord-298525-hhcfrjrn 141 9 proposed propose VBN cord-298525-hhcfrjrn 141 10 for for IN cord-298525-hhcfrjrn 141 11 the the DT cord-298525-hhcfrjrn 141 12 observed observed JJ cord-298525-hhcfrjrn 141 13 changes change NNS cord-298525-hhcfrjrn 141 14 in in IN cord-298525-hhcfrjrn 141 15 pupillary pupillary JJ cord-298525-hhcfrjrn 141 16 response response NN cord-298525-hhcfrjrn 141 17 seen see VBN cord-298525-hhcfrjrn 141 18 in in IN cord-298525-hhcfrjrn 141 19 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 141 20 's 's POS cord-298525-hhcfrjrn 141 21 and and CC cord-298525-hhcfrjrn 141 22 Parkinson Parkinson NNP cord-298525-hhcfrjrn 141 23 's 's POS cord-298525-hhcfrjrn 141 24 patients patient NNS cord-298525-hhcfrjrn 141 25 [ [ -LRB- cord-298525-hhcfrjrn 141 26 60 60 CD cord-298525-hhcfrjrn 141 27 ] ] -RRB- cord-298525-hhcfrjrn 141 28 , , , cord-298525-hhcfrjrn 141 29 but but CC cord-298525-hhcfrjrn 141 30 Fotiou Fotiou NNP cord-298525-hhcfrjrn 141 31 et et FW cord-298525-hhcfrjrn 141 32 al al NNP cord-298525-hhcfrjrn 141 33 . . . cord-298525-hhcfrjrn 142 1 [ [ -LRB- cord-298525-hhcfrjrn 142 2 57 57 CD cord-298525-hhcfrjrn 142 3 ] ] -RRB- cord-298525-hhcfrjrn 142 4 and and CC cord-298525-hhcfrjrn 142 5 others other NNS cord-298525-hhcfrjrn 142 6 have have VBP cord-298525-hhcfrjrn 142 7 concluded conclude VBN cord-298525-hhcfrjrn 142 8 that that IN cord-298525-hhcfrjrn 142 9 the the DT cord-298525-hhcfrjrn 142 10 most most RBS cord-298525-hhcfrjrn 142 11 significant significant JJ cord-298525-hhcfrjrn 142 12 factor factor NN cord-298525-hhcfrjrn 142 13 behind behind IN cord-298525-hhcfrjrn 142 14 these these DT cord-298525-hhcfrjrn 142 15 findings finding NNS cord-298525-hhcfrjrn 142 16 was be VBD cord-298525-hhcfrjrn 142 17 likely likely JJ cord-298525-hhcfrjrn 142 18 to to TO cord-298525-hhcfrjrn 142 19 be be VB cord-298525-hhcfrjrn 142 20 the the DT cord-298525-hhcfrjrn 142 21 involvement involvement NN cord-298525-hhcfrjrn 142 22 of of IN cord-298525-hhcfrjrn 142 23 a a DT cord-298525-hhcfrjrn 142 24 central central JJ cord-298525-hhcfrjrn 142 25 cholinergic cholinergic JJ cord-298525-hhcfrjrn 142 26 deficit deficit NN cord-298525-hhcfrjrn 142 27 . . . cord-298525-hhcfrjrn 143 1 Pupillometry Pupillometry NNP cord-298525-hhcfrjrn 143 2 , , , cord-298525-hhcfrjrn 143 3 including include VBG cord-298525-hhcfrjrn 143 4 repeated repeat VBN cord-298525-hhcfrjrn 143 5 light light JJ cord-298525-hhcfrjrn 143 6 stimulation stimulation NN cord-298525-hhcfrjrn 143 7 pupillometry pupillometry NN cord-298525-hhcfrjrn 143 8 , , , cord-298525-hhcfrjrn 143 9 may may MD cord-298525-hhcfrjrn 143 10 serve serve VB cord-298525-hhcfrjrn 143 11 as as IN cord-298525-hhcfrjrn 143 12 a a DT cord-298525-hhcfrjrn 143 13 useful useful JJ cord-298525-hhcfrjrn 143 14 diagnostic diagnostic JJ cord-298525-hhcfrjrn 143 15 tool tool NN cord-298525-hhcfrjrn 143 16 even even RB cord-298525-hhcfrjrn 143 17 at at IN cord-298525-hhcfrjrn 143 18 early early RB cord-298525-hhcfrjrn 143 19 , , , cord-298525-hhcfrjrn 143 20 subclinical subclinical JJ cord-298525-hhcfrjrn 143 21 stages stage NNS cord-298525-hhcfrjrn 143 22 of of IN cord-298525-hhcfrjrn 143 23 autonomic autonomic JJ cord-298525-hhcfrjrn 143 24 nervous nervous JJ cord-298525-hhcfrjrn 143 25 system system NN cord-298525-hhcfrjrn 143 26 dysfunction dysfunction NN cord-298525-hhcfrjrn 143 27 [ [ -LRB- cord-298525-hhcfrjrn 143 28 57 57 CD cord-298525-hhcfrjrn 143 29 , , , cord-298525-hhcfrjrn 143 30 58 58 CD cord-298525-hhcfrjrn 143 31 ] ] -RRB- cord-298525-hhcfrjrn 143 32 . . . cord-298525-hhcfrjrn 144 1 The the DT cord-298525-hhcfrjrn 144 2 PLR plr NN cord-298525-hhcfrjrn 144 3 is be VBZ cord-298525-hhcfrjrn 144 4 a a DT cord-298525-hhcfrjrn 144 5 well well RB cord-298525-hhcfrjrn 144 6 - - HYPH cord-298525-hhcfrjrn 144 7 established establish VBN cord-298525-hhcfrjrn 144 8 measurement measurement NN cord-298525-hhcfrjrn 144 9 in in IN cord-298525-hhcfrjrn 144 10 the the DT cord-298525-hhcfrjrn 144 11 management management NN cord-298525-hhcfrjrn 144 12 and and CC cord-298525-hhcfrjrn 144 13 prognosis prognosis NN cord-298525-hhcfrjrn 144 14 of of IN cord-298525-hhcfrjrn 144 15 patients patient NNS cord-298525-hhcfrjrn 144 16 with with IN cord-298525-hhcfrjrn 144 17 acute acute JJ cord-298525-hhcfrjrn 144 18 brain brain NN cord-298525-hhcfrjrn 144 19 injuries injury NNS cord-298525-hhcfrjrn 144 20 , , , cord-298525-hhcfrjrn 144 21 in in IN cord-298525-hhcfrjrn 144 22 conjunction conjunction NN cord-298525-hhcfrjrn 144 23 with with IN cord-298525-hhcfrjrn 144 24 other other JJ cord-298525-hhcfrjrn 144 25 clinical clinical JJ cord-298525-hhcfrjrn 144 26 parameters parameter NNS cord-298525-hhcfrjrn 144 27 such such JJ cord-298525-hhcfrjrn 144 28 as as IN cord-298525-hhcfrjrn 144 29 age age NN cord-298525-hhcfrjrn 144 30 , , , cord-298525-hhcfrjrn 144 31 mode mode NN cord-298525-hhcfrjrn 144 32 of of IN cord-298525-hhcfrjrn 144 33 injury injury NN cord-298525-hhcfrjrn 144 34 and and CC cord-298525-hhcfrjrn 144 35 Glasgow Glasgow NNP cord-298525-hhcfrjrn 144 36 Coma Coma NNP cord-298525-hhcfrjrn 144 37 Scale Scale NNP cord-298525-hhcfrjrn 144 38 [ [ -LRB- cord-298525-hhcfrjrn 144 39 79 79 CD cord-298525-hhcfrjrn 144 40 ] ] -RRB- cord-298525-hhcfrjrn 145 1 [ [ -LRB- cord-298525-hhcfrjrn 145 2 80 80 CD cord-298525-hhcfrjrn 145 3 ] ] -RRB- cord-298525-hhcfrjrn 145 4 [ [ -LRB- cord-298525-hhcfrjrn 145 5 81 81 CD cord-298525-hhcfrjrn 145 6 ] ] -RRB- cord-298525-hhcfrjrn 145 7 . . . cord-298525-hhcfrjrn 146 1 Typical typical JJ cord-298525-hhcfrjrn 146 2 light light JJ cord-298525-hhcfrjrn 146 3 stimuli stimulus NNS cord-298525-hhcfrjrn 146 4 parameters parameter NNS cord-298525-hhcfrjrn 146 5 are be VBP cord-298525-hhcfrjrn 146 6 a a DT cord-298525-hhcfrjrn 146 7 465 465 CD cord-298525-hhcfrjrn 146 8 nm nm NN cord-298525-hhcfrjrn 146 9 wavelength wavelength NN cord-298525-hhcfrjrn 146 10 with with IN cord-298525-hhcfrjrn 146 11 a a DT cord-298525-hhcfrjrn 146 12 duration duration NN cord-298525-hhcfrjrn 146 13 of of IN cord-298525-hhcfrjrn 146 14 1 1 CD cord-298525-hhcfrjrn 146 15 s s NN cord-298525-hhcfrjrn 146 16 and and CC cord-298525-hhcfrjrn 146 17 low low JJ cord-298525-hhcfrjrn 146 18 luminance luminance NN cord-298525-hhcfrjrn 146 19 ( ( -LRB- cord-298525-hhcfrjrn 146 20 0.001 0.001 CD cord-298525-hhcfrjrn 146 21 cd cd NN cord-298525-hhcfrjrn 146 22 / / SYM cord-298525-hhcfrjrn 146 23 m m NNP cord-298525-hhcfrjrn 146 24 2 2 CD cord-298525-hhcfrjrn 146 25 ) ) -RRB- cord-298525-hhcfrjrn 146 26 used use VBN cord-298525-hhcfrjrn 146 27 to to TO cord-298525-hhcfrjrn 146 28 stimulate stimulate VB cord-298525-hhcfrjrn 146 29 rod rod NN cord-298525-hhcfrjrn 146 30 cells cell NNS cord-298525-hhcfrjrn 146 31 or or CC cord-298525-hhcfrjrn 146 32 high high JJ cord-298525-hhcfrjrn 146 33 luminance luminance NN cord-298525-hhcfrjrn 146 34 ( ( -LRB- cord-298525-hhcfrjrn 146 35 450 450 CD cord-298525-hhcfrjrn 146 36 cd cd NN cord-298525-hhcfrjrn 146 37 / / SYM cord-298525-hhcfrjrn 146 38 m m NN cord-298525-hhcfrjrn 146 39 2 2 CD cord-298525-hhcfrjrn 146 40 ) ) -RRB- cord-298525-hhcfrjrn 146 41 used use VBD cord-298525-hhcfrjrn 146 42 to to TO cord-298525-hhcfrjrn 146 43 stimulate stimulate VB cord-298525-hhcfrjrn 146 44 ipRGCs iprgcs JJ cord-298525-hhcfrjrn 146 45 . . . cord-298525-hhcfrjrn 147 1 In in IN cord-298525-hhcfrjrn 147 2 particular particular JJ cord-298525-hhcfrjrn 147 3 , , , cord-298525-hhcfrjrn 147 4 the the DT cord-298525-hhcfrjrn 147 5 location location NN cord-298525-hhcfrjrn 147 6 of of IN cord-298525-hhcfrjrn 147 7 the the DT cord-298525-hhcfrjrn 147 8 pupillomotor pupillomotor NN cord-298525-hhcfrjrn 147 9 nuclei nucleus NNS cord-298525-hhcfrjrn 147 10 within within IN cord-298525-hhcfrjrn 147 11 the the DT cord-298525-hhcfrjrn 147 12 dorsal dorsal JJ cord-298525-hhcfrjrn 147 13 midbrain midbrain NN cord-298525-hhcfrjrn 147 14 and and CC cord-298525-hhcfrjrn 147 15 efferent efferent JJ cord-298525-hhcfrjrn 147 16 oculomotor oculomotor NN cord-298525-hhcfrjrn 147 17 nerve nerve NN cord-298525-hhcfrjrn 147 18 are be VBP cord-298525-hhcfrjrn 147 19 important important JJ cord-298525-hhcfrjrn 147 20 in in IN cord-298525-hhcfrjrn 147 21 the the DT cord-298525-hhcfrjrn 147 22 determination determination NN cord-298525-hhcfrjrn 147 23 of of IN cord-298525-hhcfrjrn 147 24 brainstem brainstem NN cord-298525-hhcfrjrn 147 25 compression compression NN cord-298525-hhcfrjrn 147 26 and and CC cord-298525-hhcfrjrn 147 27 the the DT cord-298525-hhcfrjrn 147 28 onset onset NN cord-298525-hhcfrjrn 147 29 of of IN cord-298525-hhcfrjrn 147 30 transtentorial transtentorial JJ cord-298525-hhcfrjrn 147 31 herniation herniation NN cord-298525-hhcfrjrn 147 32 [ [ -LRB- cord-298525-hhcfrjrn 147 33 82 82 CD cord-298525-hhcfrjrn 147 34 ] ] -RRB- cord-298525-hhcfrjrn 147 35 . . . cord-298525-hhcfrjrn 148 1 Morris Morris NNP cord-298525-hhcfrjrn 148 2 et et NNP cord-298525-hhcfrjrn 148 3 al al NNP cord-298525-hhcfrjrn 148 4 . . NNP cord-298525-hhcfrjrn 148 5 reported report VBD cord-298525-hhcfrjrn 148 6 that that IN cord-298525-hhcfrjrn 148 7 loss loss NN cord-298525-hhcfrjrn 148 8 of of IN cord-298525-hhcfrjrn 148 9 the the DT cord-298525-hhcfrjrn 148 10 PLR plr NN cord-298525-hhcfrjrn 148 11 or or CC cord-298525-hhcfrjrn 148 12 development development NN cord-298525-hhcfrjrn 148 13 of of IN cord-298525-hhcfrjrn 148 14 anisocoria anisocoria NN cord-298525-hhcfrjrn 148 15 or or CC cord-298525-hhcfrjrn 148 16 pupil pupil NN cord-298525-hhcfrjrn 148 17 asymmetry asymmetry NN cord-298525-hhcfrjrn 148 18 > > XX cord-298525-hhcfrjrn 148 19 2 2 CD cord-298525-hhcfrjrn 148 20 mm mm NN cord-298525-hhcfrjrn 148 21 in in IN cord-298525-hhcfrjrn 148 22 patients patient NNS cord-298525-hhcfrjrn 148 23 who who WP cord-298525-hhcfrjrn 148 24 sustained sustain VBD cord-298525-hhcfrjrn 148 25 traumatic traumatic JJ cord-298525-hhcfrjrn 148 26 brain brain NN cord-298525-hhcfrjrn 148 27 injuries injury NNS cord-298525-hhcfrjrn 148 28 was be VBD cord-298525-hhcfrjrn 148 29 correlated correlate VBN cord-298525-hhcfrjrn 148 30 with with IN cord-298525-hhcfrjrn 148 31 increased increase VBN cord-298525-hhcfrjrn 148 32 morbidity morbidity NN cord-298525-hhcfrjrn 148 33 and and CC cord-298525-hhcfrjrn 148 34 mortality mortality NN cord-298525-hhcfrjrn 148 35 rates rate NNS cord-298525-hhcfrjrn 148 36 [ [ -LRB- cord-298525-hhcfrjrn 148 37 83 83 CD cord-298525-hhcfrjrn 148 38 ] ] -RRB- cord-298525-hhcfrjrn 148 39 . . . cord-298525-hhcfrjrn 149 1 However however RB cord-298525-hhcfrjrn 149 2 , , , cord-298525-hhcfrjrn 149 3 manual manual JJ cord-298525-hhcfrjrn 149 4 examination examination NN cord-298525-hhcfrjrn 149 5 using use VBG cord-298525-hhcfrjrn 149 6 a a DT cord-298525-hhcfrjrn 149 7 penlight penlight NN cord-298525-hhcfrjrn 149 8 is be VBZ cord-298525-hhcfrjrn 149 9 subject subject JJ cord-298525-hhcfrjrn 149 10 to to IN cord-298525-hhcfrjrn 149 11 large large JJ cord-298525-hhcfrjrn 149 12 inter inter JJ cord-298525-hhcfrjrn 149 13 - - NN cord-298525-hhcfrjrn 149 14 examiner examiner JJ cord-298525-hhcfrjrn 149 15 discrepancies discrepancy NNS cord-298525-hhcfrjrn 149 16 that that WDT cord-298525-hhcfrjrn 149 17 can can MD cord-298525-hhcfrjrn 149 18 be be VB cord-298525-hhcfrjrn 149 19 as as RB cord-298525-hhcfrjrn 149 20 high high JJ cord-298525-hhcfrjrn 149 21 as as IN cord-298525-hhcfrjrn 149 22 40 40 CD cord-298525-hhcfrjrn 149 23 % % NN cord-298525-hhcfrjrn 149 24 , , , cord-298525-hhcfrjrn 149 25 particularly particularly RB cord-298525-hhcfrjrn 149 26 when when WRB cord-298525-hhcfrjrn 149 27 pupils pupil NNS cord-298525-hhcfrjrn 149 28 are be VBP cord-298525-hhcfrjrn 149 29 constricted constrict VBN cord-298525-hhcfrjrn 149 30 [ [ -LRB- cord-298525-hhcfrjrn 149 31 84 84 CD cord-298525-hhcfrjrn 149 32 ] ] -RRB- cord-298525-hhcfrjrn 149 33 , , , cord-298525-hhcfrjrn 149 34 and and CC cord-298525-hhcfrjrn 149 35 these these DT cord-298525-hhcfrjrn 149 36 may may MD cord-298525-hhcfrjrn 149 37 be be VB cord-298525-hhcfrjrn 149 38 further further RB cord-298525-hhcfrjrn 149 39 confounded confound VBN cord-298525-hhcfrjrn 149 40 by by IN cord-298525-hhcfrjrn 149 41 a a DT cord-298525-hhcfrjrn 149 42 variety variety NN cord-298525-hhcfrjrn 149 43 of of IN cord-298525-hhcfrjrn 149 44 factors factor NNS cord-298525-hhcfrjrn 149 45 , , , cord-298525-hhcfrjrn 149 46 including include VBG cord-298525-hhcfrjrn 149 47 alcohol alcohol NN cord-298525-hhcfrjrn 149 48 , , , cord-298525-hhcfrjrn 149 49 narcotics narcotic NNS cord-298525-hhcfrjrn 149 50 or or CC cord-298525-hhcfrjrn 149 51 hypothermia hypothermia NN cord-298525-hhcfrjrn 149 52 , , , cord-298525-hhcfrjrn 149 53 which which WDT cord-298525-hhcfrjrn 149 54 are be VBP cord-298525-hhcfrjrn 149 55 common common JJ cord-298525-hhcfrjrn 149 56 to to IN cord-298525-hhcfrjrn 149 57 many many JJ cord-298525-hhcfrjrn 149 58 trauma trauma NN cord-298525-hhcfrjrn 149 59 patients patient NNS cord-298525-hhcfrjrn 149 60 [ [ -LRB- cord-298525-hhcfrjrn 149 61 85 85 CD cord-298525-hhcfrjrn 149 62 ] ] -RRB- cord-298525-hhcfrjrn 149 63 . . . cord-298525-hhcfrjrn 150 1 Furthermore furthermore RB cord-298525-hhcfrjrn 150 2 , , , cord-298525-hhcfrjrn 150 3 Couret Couret NNP cord-298525-hhcfrjrn 150 4 et et NNP cord-298525-hhcfrjrn 150 5 al al NNP cord-298525-hhcfrjrn 150 6 . . . cord-298525-hhcfrjrn 151 1 observed observe VBD cord-298525-hhcfrjrn 151 2 an an DT cord-298525-hhcfrjrn 151 3 error error NN cord-298525-hhcfrjrn 151 4 rate rate NN cord-298525-hhcfrjrn 151 5 of of IN cord-298525-hhcfrjrn 151 6 approximately approximately RB cord-298525-hhcfrjrn 151 7 20 20 CD cord-298525-hhcfrjrn 151 8 % % NN cord-298525-hhcfrjrn 151 9 even even RB cord-298525-hhcfrjrn 151 10 for for IN cord-298525-hhcfrjrn 151 11 intermediate intermediate JJ cord-298525-hhcfrjrn 151 12 - - HYPH cord-298525-hhcfrjrn 151 13 sized sized JJ cord-298525-hhcfrjrn 151 14 pupils pupil NNS cord-298525-hhcfrjrn 151 15 ( ( -LRB- cord-298525-hhcfrjrn 151 16 2 2 CD cord-298525-hhcfrjrn 151 17 - - SYM cord-298525-hhcfrjrn 151 18 4 4 CD cord-298525-hhcfrjrn 151 19 mm mm NNP cord-298525-hhcfrjrn 151 20 ) ) -RRB- cord-298525-hhcfrjrn 151 21 , , , cord-298525-hhcfrjrn 151 22 with with IN cord-298525-hhcfrjrn 151 23 a a DT cord-298525-hhcfrjrn 151 24 50 50 CD cord-298525-hhcfrjrn 151 25 % % NN cord-298525-hhcfrjrn 151 26 failure failure NN cord-298525-hhcfrjrn 151 27 rate rate NN cord-298525-hhcfrjrn 151 28 in in IN cord-298525-hhcfrjrn 151 29 the the DT cord-298525-hhcfrjrn 151 30 detection detection NN cord-298525-hhcfrjrn 151 31 of of IN cord-298525-hhcfrjrn 151 32 anisocoria anisocoria NN cord-298525-hhcfrjrn 151 33 [ [ -LRB- cord-298525-hhcfrjrn 151 34 86 86 CD cord-298525-hhcfrjrn 151 35 ] ] -RRB- cord-298525-hhcfrjrn 151 36 . . . cord-298525-hhcfrjrn 152 1 Additionally additionally RB cord-298525-hhcfrjrn 152 2 , , , cord-298525-hhcfrjrn 152 3 Larson Larson NNP cord-298525-hhcfrjrn 152 4 and and CC cord-298525-hhcfrjrn 152 5 Muhiudeen Muhiudeen NNP cord-298525-hhcfrjrn 152 6 found find VBD cord-298525-hhcfrjrn 152 7 complete complete JJ cord-298525-hhcfrjrn 152 8 failure failure NN cord-298525-hhcfrjrn 152 9 in in IN cord-298525-hhcfrjrn 152 10 the the DT cord-298525-hhcfrjrn 152 11 detection detection NN cord-298525-hhcfrjrn 152 12 of of IN cord-298525-hhcfrjrn 152 13 the the DT cord-298525-hhcfrjrn 152 14 PLR PLR NNP cord-298525-hhcfrjrn 152 15 by by IN cord-298525-hhcfrjrn 152 16 manual manual JJ cord-298525-hhcfrjrn 152 17 examination examination NN cord-298525-hhcfrjrn 152 18 when when WRB cord-298525-hhcfrjrn 152 19 the the DT cord-298525-hhcfrjrn 152 20 reflex reflex NN cord-298525-hhcfrjrn 152 21 amplitude amplitude NN cord-298525-hhcfrjrn 152 22 was be VBD cord-298525-hhcfrjrn 152 23 less less JJR cord-298525-hhcfrjrn 152 24 than than IN cord-298525-hhcfrjrn 152 25 0.3 0.3 CD cord-298525-hhcfrjrn 152 26 mm mm XX cord-298525-hhcfrjrn 152 27 [ [ -LRB- cord-298525-hhcfrjrn 152 28 87 87 CD cord-298525-hhcfrjrn 152 29 ] ] -RRB- cord-298525-hhcfrjrn 152 30 . . . cord-298525-hhcfrjrn 153 1 Automated automate VBN cord-298525-hhcfrjrn 153 2 pupillometry pupillometry NN cord-298525-hhcfrjrn 153 3 using use VBG cord-298525-hhcfrjrn 153 4 a a DT cord-298525-hhcfrjrn 153 5 pupillometer pupillometer NN cord-298525-hhcfrjrn 153 6 is be VBZ cord-298525-hhcfrjrn 153 7 a a DT cord-298525-hhcfrjrn 153 8 more more RBR cord-298525-hhcfrjrn 153 9 sensitive sensitive JJ cord-298525-hhcfrjrn 153 10 technique technique NN cord-298525-hhcfrjrn 153 11 that that WDT cord-298525-hhcfrjrn 153 12 has have VBZ cord-298525-hhcfrjrn 153 13 smaller small JJR cord-298525-hhcfrjrn 153 14 inter inter JJ cord-298525-hhcfrjrn 153 15 - - JJ cord-298525-hhcfrjrn 153 16 examiner examiner JJ cord-298525-hhcfrjrn 153 17 discrepancies discrepancy NNS cord-298525-hhcfrjrn 153 18 compared compare VBN cord-298525-hhcfrjrn 153 19 to to IN cord-298525-hhcfrjrn 153 20 manual manual JJ cord-298525-hhcfrjrn 153 21 examination examination NN cord-298525-hhcfrjrn 153 22 [ [ -LRB- cord-298525-hhcfrjrn 153 23 86 86 CD cord-298525-hhcfrjrn 153 24 , , , cord-298525-hhcfrjrn 153 25 88 88 CD cord-298525-hhcfrjrn 153 26 ] ] -RRB- cord-298525-hhcfrjrn 153 27 . . . cord-298525-hhcfrjrn 154 1 The the DT cord-298525-hhcfrjrn 154 2 ability ability NN cord-298525-hhcfrjrn 154 3 of of IN cord-298525-hhcfrjrn 154 4 pupillometry pupillometry NN cord-298525-hhcfrjrn 154 5 to to TO cord-298525-hhcfrjrn 154 6 detect detect VB cord-298525-hhcfrjrn 154 7 subtle subtle JJ cord-298525-hhcfrjrn 154 8 changes change NNS cord-298525-hhcfrjrn 154 9 in in IN cord-298525-hhcfrjrn 154 10 pupillary pupillary JJ cord-298525-hhcfrjrn 154 11 reaction reaction NN cord-298525-hhcfrjrn 154 12 even even RB cord-298525-hhcfrjrn 154 13 when when WRB cord-298525-hhcfrjrn 154 14 pupils pupil NNS cord-298525-hhcfrjrn 154 15 are be VBP cord-298525-hhcfrjrn 154 16 constricted constrict VBN cord-298525-hhcfrjrn 154 17 has have VBZ cord-298525-hhcfrjrn 154 18 potential potential JJ cord-298525-hhcfrjrn 154 19 clinical clinical JJ cord-298525-hhcfrjrn 154 20 significance significance NN cord-298525-hhcfrjrn 154 21 and and CC cord-298525-hhcfrjrn 154 22 may may MD cord-298525-hhcfrjrn 154 23 provide provide VB cord-298525-hhcfrjrn 154 24 a a DT cord-298525-hhcfrjrn 154 25 useful useful JJ cord-298525-hhcfrjrn 154 26 tool tool NN cord-298525-hhcfrjrn 154 27 in in IN cord-298525-hhcfrjrn 154 28 the the DT cord-298525-hhcfrjrn 154 29 early early JJ cord-298525-hhcfrjrn 154 30 detection detection NN cord-298525-hhcfrjrn 154 31 , , , cord-298525-hhcfrjrn 154 32 monitoring monitoring NN cord-298525-hhcfrjrn 154 33 and and CC cord-298525-hhcfrjrn 154 34 management management NN cord-298525-hhcfrjrn 154 35 of of IN cord-298525-hhcfrjrn 154 36 brain brain NN cord-298525-hhcfrjrn 154 37 injuries injury NNS cord-298525-hhcfrjrn 154 38 [ [ -LRB- cord-298525-hhcfrjrn 154 39 89 89 CD cord-298525-hhcfrjrn 154 40 ] ] -RRB- cord-298525-hhcfrjrn 154 41 . . . cord-298525-hhcfrjrn 155 1 In in IN cord-298525-hhcfrjrn 155 2 support support NN cord-298525-hhcfrjrn 155 3 of of IN cord-298525-hhcfrjrn 155 4 this this DT cord-298525-hhcfrjrn 155 5 , , , cord-298525-hhcfrjrn 155 6 several several JJ cord-298525-hhcfrjrn 155 7 groups group NNS cord-298525-hhcfrjrn 155 8 have have VBP cord-298525-hhcfrjrn 155 9 demonstrated demonstrate VBN cord-298525-hhcfrjrn 155 10 that that IN cord-298525-hhcfrjrn 155 11 use use NN cord-298525-hhcfrjrn 155 12 of of IN cord-298525-hhcfrjrn 155 13 a a DT cord-298525-hhcfrjrn 155 14 pupillometer pupillometer NN cord-298525-hhcfrjrn 155 15 was be VBD cord-298525-hhcfrjrn 155 16 superior superior JJ cord-298525-hhcfrjrn 155 17 to to IN cord-298525-hhcfrjrn 155 18 manual manual JJ cord-298525-hhcfrjrn 155 19 assessment assessment NN cord-298525-hhcfrjrn 155 20 in in IN cord-298525-hhcfrjrn 155 21 predicting predict VBG cord-298525-hhcfrjrn 155 22 the the DT cord-298525-hhcfrjrn 155 23 90-day 90-day CD cord-298525-hhcfrjrn 155 24 outcome outcome NN cord-298525-hhcfrjrn 155 25 following follow VBG cord-298525-hhcfrjrn 155 26 cardiac cardiac JJ cord-298525-hhcfrjrn 155 27 arrest arrest NN cord-298525-hhcfrjrn 155 28 [ [ -LRB- cord-298525-hhcfrjrn 155 29 90 90 CD cord-298525-hhcfrjrn 155 30 , , , cord-298525-hhcfrjrn 155 31 91 91 CD cord-298525-hhcfrjrn 155 32 ] ] -RRB- cord-298525-hhcfrjrn 155 33 . . . cord-298525-hhcfrjrn 156 1 The the DT cord-298525-hhcfrjrn 156 2 cholinergic cholinergic JJ cord-298525-hhcfrjrn 156 3 system system NN cord-298525-hhcfrjrn 156 4 is be VBZ cord-298525-hhcfrjrn 156 5 key key JJ cord-298525-hhcfrjrn 156 6 to to IN cord-298525-hhcfrjrn 156 7 normal normal JJ cord-298525-hhcfrjrn 156 8 pre pre JJ cord-298525-hhcfrjrn 156 9 - - JJ cord-298525-hhcfrjrn 156 10 and and CC cord-298525-hhcfrjrn 156 11 postnatal postnatal JJ cord-298525-hhcfrjrn 156 12 neurodevelopment neurodevelopment NN cord-298525-hhcfrjrn 156 13 , , , cord-298525-hhcfrjrn 156 14 and and CC cord-298525-hhcfrjrn 156 15 numerous numerous JJ cord-298525-hhcfrjrn 156 16 studies study NNS cord-298525-hhcfrjrn 156 17 , , , cord-298525-hhcfrjrn 156 18 ranging range VBG cord-298525-hhcfrjrn 156 19 from from IN cord-298525-hhcfrjrn 156 20 neuroimaging neuroimage VBG cord-298525-hhcfrjrn 156 21 data datum NNS cord-298525-hhcfrjrn 156 22 [ [ -LRB- cord-298525-hhcfrjrn 156 23 92 92 CD cord-298525-hhcfrjrn 156 24 ] ] -RRB- cord-298525-hhcfrjrn 156 25 , , , cord-298525-hhcfrjrn 156 26 to to TO cord-298525-hhcfrjrn 156 27 post post VB cord-298525-hhcfrjrn 156 28 mortem mortem FW cord-298525-hhcfrjrn 156 29 histopathological histopathological JJ cord-298525-hhcfrjrn 156 30 analysis analysis NN cord-298525-hhcfrjrn 156 31 of of IN cord-298525-hhcfrjrn 156 32 brain brain NN cord-298525-hhcfrjrn 156 33 tissue tissue NN cord-298525-hhcfrjrn 156 34 [ [ -LRB- cord-298525-hhcfrjrn 156 35 93 93 CD cord-298525-hhcfrjrn 156 36 , , , cord-298525-hhcfrjrn 156 37 94 94 CD cord-298525-hhcfrjrn 156 38 ] ] -RRB- cord-298525-hhcfrjrn 156 39 , , , cord-298525-hhcfrjrn 156 40 animal animal NN cord-298525-hhcfrjrn 156 41 models model NNS cord-298525-hhcfrjrn 156 42 [ [ -LRB- cord-298525-hhcfrjrn 156 43 95 95 CD cord-298525-hhcfrjrn 156 44 , , , cord-298525-hhcfrjrn 156 45 96 96 CD cord-298525-hhcfrjrn 156 46 ] ] -RRB- cord-298525-hhcfrjrn 156 47 and and CC cord-298525-hhcfrjrn 156 48 molecular molecular JJ cord-298525-hhcfrjrn 156 49 genetic genetic JJ cord-298525-hhcfrjrn 156 50 studies study NNS cord-298525-hhcfrjrn 156 51 [ [ -LRB- cord-298525-hhcfrjrn 156 52 97 97 CD cord-298525-hhcfrjrn 156 53 ] ] -RRB- cord-298525-hhcfrjrn 156 54 , , , cord-298525-hhcfrjrn 156 55 have have VBP cord-298525-hhcfrjrn 156 56 suggested suggest VBN cord-298525-hhcfrjrn 156 57 that that IN cord-298525-hhcfrjrn 156 58 alterations alteration NNS cord-298525-hhcfrjrn 156 59 in in IN cord-298525-hhcfrjrn 156 60 the the DT cord-298525-hhcfrjrn 156 61 cholinergic cholinergic JJ cord-298525-hhcfrjrn 156 62 system system NN cord-298525-hhcfrjrn 156 63 may may MD cord-298525-hhcfrjrn 156 64 be be VB cord-298525-hhcfrjrn 156 65 a a DT cord-298525-hhcfrjrn 156 66 contributing contribute VBG cord-298525-hhcfrjrn 156 67 factor factor NN cord-298525-hhcfrjrn 156 68 to to IN cord-298525-hhcfrjrn 156 69 the the DT cord-298525-hhcfrjrn 156 70 aetiology aetiology NN cord-298525-hhcfrjrn 156 71 of of IN cord-298525-hhcfrjrn 156 72 autism autism NN cord-298525-hhcfrjrn 156 73 spectrum spectrum NN cord-298525-hhcfrjrn 156 74 disorder disorder NN cord-298525-hhcfrjrn 156 75 ( ( -LRB- cord-298525-hhcfrjrn 156 76 ASD ASD NNP cord-298525-hhcfrjrn 156 77 ) ) -RRB- cord-298525-hhcfrjrn 156 78 . . . cord-298525-hhcfrjrn 157 1 Moreover moreover RB cord-298525-hhcfrjrn 157 2 , , , cord-298525-hhcfrjrn 157 3 an an DT cord-298525-hhcfrjrn 157 4 atypical atypical JJ cord-298525-hhcfrjrn 157 5 PLR plr NN cord-298525-hhcfrjrn 157 6 is be VBZ cord-298525-hhcfrjrn 157 7 reported report VBN cord-298525-hhcfrjrn 157 8 in in IN cord-298525-hhcfrjrn 157 9 both both DT cord-298525-hhcfrjrn 157 10 children child NNS cord-298525-hhcfrjrn 157 11 and and CC cord-298525-hhcfrjrn 157 12 adults adult NNS cord-298525-hhcfrjrn 157 13 with with IN cord-298525-hhcfrjrn 157 14 ASD ASD NNP cord-298525-hhcfrjrn 157 15 [ [ -LRB- cord-298525-hhcfrjrn 157 16 60 60 CD cord-298525-hhcfrjrn 157 17 , , , cord-298525-hhcfrjrn 157 18 [ [ -LRB- cord-298525-hhcfrjrn 157 19 98 98 CD cord-298525-hhcfrjrn 157 20 ] ] -RRB- cord-298525-hhcfrjrn 157 21 [ [ -LRB- cord-298525-hhcfrjrn 157 22 99 99 CD cord-298525-hhcfrjrn 157 23 ] ] -RRB- cord-298525-hhcfrjrn 157 24 [ [ -LRB- cord-298525-hhcfrjrn 157 25 100 100 CD cord-298525-hhcfrjrn 157 26 ] ] -RRB- cord-298525-hhcfrjrn 157 27 . . . cord-298525-hhcfrjrn 158 1 Common common JJ cord-298525-hhcfrjrn 158 2 measurement measurement NN cord-298525-hhcfrjrn 158 3 parameters parameter NNS cord-298525-hhcfrjrn 158 4 used use VBN cord-298525-hhcfrjrn 158 5 include include VBP cord-298525-hhcfrjrn 158 6 a a DT cord-298525-hhcfrjrn 158 7 light light JJ cord-298525-hhcfrjrn 158 8 stimulus stimulus NN cord-298525-hhcfrjrn 158 9 wavelength wavelength NN cord-298525-hhcfrjrn 158 10 of of IN cord-298525-hhcfrjrn 158 11 530 530 CD cord-298525-hhcfrjrn 158 12 nm nm NN cord-298525-hhcfrjrn 158 13 and and CC cord-298525-hhcfrjrn 158 14 a a DT cord-298525-hhcfrjrn 158 15 duration duration NN cord-298525-hhcfrjrn 158 16 of of IN cord-298525-hhcfrjrn 158 17 100 100 CD cord-298525-hhcfrjrn 158 18 ms m NNS cord-298525-hhcfrjrn 158 19 with with IN cord-298525-hhcfrjrn 158 20 a a DT cord-298525-hhcfrjrn 158 21 light light JJ cord-298525-hhcfrjrn 158 22 intensity intensity NN cord-298525-hhcfrjrn 158 23 of of IN cord-298525-hhcfrjrn 158 24 63.1 63.1 CD cord-298525-hhcfrjrn 158 25 cd cd NN cord-298525-hhcfrjrn 158 26 / / SYM cord-298525-hhcfrjrn 158 27 m m NN cord-298525-hhcfrjrn 158 28 2 2 CD cord-298525-hhcfrjrn 158 29 . . . cord-298525-hhcfrjrn 159 1 Typically typically RB cord-298525-hhcfrjrn 159 2 , , , cord-298525-hhcfrjrn 159 3 these these DT cord-298525-hhcfrjrn 159 4 differences difference NNS cord-298525-hhcfrjrn 159 5 are be VBP cord-298525-hhcfrjrn 159 6 characterised characterise VBN cord-298525-hhcfrjrn 159 7 by by IN cord-298525-hhcfrjrn 159 8 longer long JJR cord-298525-hhcfrjrn 159 9 latency latency NN cord-298525-hhcfrjrn 159 10 , , , cord-298525-hhcfrjrn 159 11 reduced reduce VBN cord-298525-hhcfrjrn 159 12 constriction constriction NN cord-298525-hhcfrjrn 159 13 amplitude amplitude NN cord-298525-hhcfrjrn 159 14 [ [ -LRB- cord-298525-hhcfrjrn 159 15 61 61 CD cord-298525-hhcfrjrn 159 16 , , , cord-298525-hhcfrjrn 159 17 99 99 CD cord-298525-hhcfrjrn 159 18 ] ] -RRB- cord-298525-hhcfrjrn 159 19 and and CC cord-298525-hhcfrjrn 159 20 reduced reduce VBN cord-298525-hhcfrjrn 159 21 constriction constriction NN cord-298525-hhcfrjrn 159 22 velocity velocity NN cord-298525-hhcfrjrn 159 23 [ [ -LRB- cord-298525-hhcfrjrn 159 24 61 61 CD cord-298525-hhcfrjrn 159 25 ] ] -RRB- cord-298525-hhcfrjrn 159 26 compared compare VBN cord-298525-hhcfrjrn 159 27 to to IN cord-298525-hhcfrjrn 159 28 children child NNS cord-298525-hhcfrjrn 159 29 without without IN cord-298525-hhcfrjrn 159 30 ASD ASD NNP cord-298525-hhcfrjrn 159 31 . . . cord-298525-hhcfrjrn 160 1 However however RB cord-298525-hhcfrjrn 160 2 , , , cord-298525-hhcfrjrn 160 3 Nyström Nyström NNP cord-298525-hhcfrjrn 160 4 et et NNP cord-298525-hhcfrjrn 160 5 al al NNP cord-298525-hhcfrjrn 160 6 . . NNP cord-298525-hhcfrjrn 160 7 reported report VBD cord-298525-hhcfrjrn 160 8 the the DT cord-298525-hhcfrjrn 160 9 opposite opposite NN cord-298525-hhcfrjrn 160 10 for for IN cord-298525-hhcfrjrn 160 11 high high JJ cord-298525-hhcfrjrn 160 12 ASD asd NN cord-298525-hhcfrjrn 160 13 - - HYPH cord-298525-hhcfrjrn 160 14 risk risk NN cord-298525-hhcfrjrn 160 15 infants infant NNS cord-298525-hhcfrjrn 160 16 , , , cord-298525-hhcfrjrn 160 17 defined define VBN cord-298525-hhcfrjrn 160 18 as as IN cord-298525-hhcfrjrn 160 19 those those DT cord-298525-hhcfrjrn 160 20 who who WP cord-298525-hhcfrjrn 160 21 had have VBD cord-298525-hhcfrjrn 160 22 a a DT cord-298525-hhcfrjrn 160 23 sibling sibling NN cord-298525-hhcfrjrn 160 24 with with IN cord-298525-hhcfrjrn 160 25 ASD ASD NNP cord-298525-hhcfrjrn 160 26 . . . cord-298525-hhcfrjrn 161 1 The the DT cord-298525-hhcfrjrn 161 2 difference difference NN cord-298525-hhcfrjrn 161 3 in in IN cord-298525-hhcfrjrn 161 4 age age NN cord-298525-hhcfrjrn 161 5 among among IN cord-298525-hhcfrjrn 161 6 the the DT cord-298525-hhcfrjrn 161 7 studies study NNS cord-298525-hhcfrjrn 161 8 ' ' POS cord-298525-hhcfrjrn 161 9 subjects subject NNS cord-298525-hhcfrjrn 161 10 , , , cord-298525-hhcfrjrn 161 11 who who WP cord-298525-hhcfrjrn 161 12 ranged range VBD cord-298525-hhcfrjrn 161 13 from from IN cord-298525-hhcfrjrn 161 14 10-month 10-month JJ cord-298525-hhcfrjrn 161 15 - - HYPH cord-298525-hhcfrjrn 161 16 old old JJ cord-298525-hhcfrjrn 161 17 infants infant NNS cord-298525-hhcfrjrn 161 18 [ [ -LRB- cord-298525-hhcfrjrn 161 19 100 100 CD cord-298525-hhcfrjrn 161 20 ] ] -RRB- cord-298525-hhcfrjrn 161 21 up up IN cord-298525-hhcfrjrn 161 22 to to IN cord-298525-hhcfrjrn 161 23 children child NNS cord-298525-hhcfrjrn 161 24 > > XX cord-298525-hhcfrjrn 161 25 5 5 CD cord-298525-hhcfrjrn 161 26 years year NNS cord-298525-hhcfrjrn 161 27 of of IN cord-298525-hhcfrjrn 161 28 age age NN cord-298525-hhcfrjrn 161 29 [ [ -LRB- cord-298525-hhcfrjrn 161 30 61 61 CD cord-298525-hhcfrjrn 161 31 , , , cord-298525-hhcfrjrn 161 32 98 98 CD cord-298525-hhcfrjrn 161 33 , , , cord-298525-hhcfrjrn 161 34 99 99 CD cord-298525-hhcfrjrn 161 35 ] ] -RRB- cord-298525-hhcfrjrn 161 36 , , , cord-298525-hhcfrjrn 161 37 may may MD cord-298525-hhcfrjrn 161 38 provide provide VB cord-298525-hhcfrjrn 161 39 an an DT cord-298525-hhcfrjrn 161 40 explanation explanation NN cord-298525-hhcfrjrn 161 41 for for IN cord-298525-hhcfrjrn 161 42 the the DT cord-298525-hhcfrjrn 161 43 contrasting contrast VBG cord-298525-hhcfrjrn 161 44 data datum NNS cord-298525-hhcfrjrn 161 45 . . . cord-298525-hhcfrjrn 162 1 Children child NNS cord-298525-hhcfrjrn 162 2 without without IN cord-298525-hhcfrjrn 162 3 ASD ASD NNP cord-298525-hhcfrjrn 162 4 exhibit exhibit VBP cord-298525-hhcfrjrn 162 5 an an DT cord-298525-hhcfrjrn 162 6 age age NN cord-298525-hhcfrjrn 162 7 - - HYPH cord-298525-hhcfrjrn 162 8 dependent dependent JJ cord-298525-hhcfrjrn 162 9 decrease decrease NN cord-298525-hhcfrjrn 162 10 in in IN cord-298525-hhcfrjrn 162 11 PLR plr NN cord-298525-hhcfrjrn 162 12 latency latency NN cord-298525-hhcfrjrn 162 13 before before IN cord-298525-hhcfrjrn 162 14 reaching reach VBG cord-298525-hhcfrjrn 162 15 a a DT cord-298525-hhcfrjrn 162 16 plateau plateau NN cord-298525-hhcfrjrn 162 17 at at IN cord-298525-hhcfrjrn 162 18 > > XX cord-298525-hhcfrjrn 162 19 8 8 CD cord-298525-hhcfrjrn 162 20 years year NNS cord-298525-hhcfrjrn 162 21 of of IN cord-298525-hhcfrjrn 162 22 age age NN cord-298525-hhcfrjrn 162 23 [ [ -LRB- cord-298525-hhcfrjrn 162 24 98 98 CD cord-298525-hhcfrjrn 162 25 , , , cord-298525-hhcfrjrn 162 26 99 99 CD cord-298525-hhcfrjrn 162 27 ] ] -RRB- cord-298525-hhcfrjrn 162 28 ; ; : cord-298525-hhcfrjrn 162 29 this this DT cord-298525-hhcfrjrn 162 30 correlates correlate VBZ cord-298525-hhcfrjrn 162 31 with with IN cord-298525-hhcfrjrn 162 32 similar similar JJ cord-298525-hhcfrjrn 162 33 trends trend NNS cord-298525-hhcfrjrn 162 34 in in IN cord-298525-hhcfrjrn 162 35 white white JJ cord-298525-hhcfrjrn 162 36 - - HYPH cord-298525-hhcfrjrn 162 37 matter matter NN cord-298525-hhcfrjrn 162 38 maturation maturation NN cord-298525-hhcfrjrn 162 39 rates rate NNS cord-298525-hhcfrjrn 162 40 as as IN cord-298525-hhcfrjrn 162 41 determined determine VBN cord-298525-hhcfrjrn 162 42 by by IN cord-298525-hhcfrjrn 162 43 flash flash NN cord-298525-hhcfrjrn 162 44 visual visual JJ cord-298525-hhcfrjrn 162 45 evoked evoke VBD cord-298525-hhcfrjrn 162 46 potential potential JJ cord-298525-hhcfrjrn 162 47 studies study NNS cord-298525-hhcfrjrn 162 48 [ [ -LRB- cord-298525-hhcfrjrn 162 49 101 101 CD cord-298525-hhcfrjrn 162 50 ] ] -RRB- cord-298525-hhcfrjrn 162 51 . . . cord-298525-hhcfrjrn 163 1 However however RB cord-298525-hhcfrjrn 163 2 , , , cord-298525-hhcfrjrn 163 3 in in IN cord-298525-hhcfrjrn 163 4 children child NNS cord-298525-hhcfrjrn 163 5 with with IN cord-298525-hhcfrjrn 163 6 ASD ASD NNP cord-298525-hhcfrjrn 163 7 there there EX cord-298525-hhcfrjrn 163 8 was be VBD cord-298525-hhcfrjrn 163 9 no no DT cord-298525-hhcfrjrn 163 10 age age NN cord-298525-hhcfrjrn 163 11 - - HYPH cord-298525-hhcfrjrn 163 12 dependent dependent JJ cord-298525-hhcfrjrn 163 13 decrease decrease NN cord-298525-hhcfrjrn 163 14 in in IN cord-298525-hhcfrjrn 163 15 PLR plr NN cord-298525-hhcfrjrn 163 16 latency latency NN cord-298525-hhcfrjrn 163 17 [ [ -LRB- cord-298525-hhcfrjrn 163 18 99 99 CD cord-298525-hhcfrjrn 163 19 ] ] -RRB- cord-298525-hhcfrjrn 163 20 . . . cord-298525-hhcfrjrn 164 1 Moreover moreover RB cord-298525-hhcfrjrn 164 2 , , , cord-298525-hhcfrjrn 164 3 brain brain NN cord-298525-hhcfrjrn 164 4 - - HYPH cord-298525-hhcfrjrn 164 5 imaging imaging NN cord-298525-hhcfrjrn 164 6 studies study NNS cord-298525-hhcfrjrn 164 7 have have VBP cord-298525-hhcfrjrn 164 8 shown show VBN cord-298525-hhcfrjrn 164 9 that that IN cord-298525-hhcfrjrn 164 10 the the DT cord-298525-hhcfrjrn 164 11 neurodevelopment neurodevelopment JJ cord-298525-hhcfrjrn 164 12 trajectory trajectory NN cord-298525-hhcfrjrn 164 13 of of IN cord-298525-hhcfrjrn 164 14 brain brain NN cord-298525-hhcfrjrn 164 15 maturation maturation NN cord-298525-hhcfrjrn 164 16 is be VBZ cord-298525-hhcfrjrn 164 17 atypical atypical JJ cord-298525-hhcfrjrn 164 18 in in IN cord-298525-hhcfrjrn 164 19 children child NNS cord-298525-hhcfrjrn 164 20 with with IN cord-298525-hhcfrjrn 164 21 ASD ASD NNP cord-298525-hhcfrjrn 164 22 . . . cord-298525-hhcfrjrn 165 1 Initially initially RB cord-298525-hhcfrjrn 165 2 , , , cord-298525-hhcfrjrn 165 3 young young JJ cord-298525-hhcfrjrn 165 4 children child NNS cord-298525-hhcfrjrn 165 5 ( ( -LRB- cord-298525-hhcfrjrn 165 6 < < NNP cord-298525-hhcfrjrn 165 7 4 4 CD cord-298525-hhcfrjrn 165 8 years year NNS cord-298525-hhcfrjrn 165 9 of of IN cord-298525-hhcfrjrn 165 10 age age NN cord-298525-hhcfrjrn 165 11 ) ) -RRB- cord-298525-hhcfrjrn 165 12 exhibit exhibit NN cord-298525-hhcfrjrn 165 13 accelerated accelerate VBN cord-298525-hhcfrjrn 165 14 maturation maturation NN cord-298525-hhcfrjrn 165 15 and and CC cord-298525-hhcfrjrn 165 16 a a DT cord-298525-hhcfrjrn 165 17 larger large JJR cord-298525-hhcfrjrn 165 18 brain brain NN cord-298525-hhcfrjrn 165 19 volume volume NN cord-298525-hhcfrjrn 165 20 compared compare VBN cord-298525-hhcfrjrn 165 21 to to IN cord-298525-hhcfrjrn 165 22 children child NNS cord-298525-hhcfrjrn 165 23 without without IN cord-298525-hhcfrjrn 165 24 ASD ASD NNP cord-298525-hhcfrjrn 165 25 [ [ -LRB- cord-298525-hhcfrjrn 165 26 102 102 CD cord-298525-hhcfrjrn 165 27 ] ] -RRB- cord-298525-hhcfrjrn 166 1 [ [ -LRB- cord-298525-hhcfrjrn 166 2 103 103 CD cord-298525-hhcfrjrn 166 3 ] ] -RRB- cord-298525-hhcfrjrn 166 4 [ [ -LRB- cord-298525-hhcfrjrn 166 5 104 104 CD cord-298525-hhcfrjrn 166 6 ] ] -RRB- cord-298525-hhcfrjrn 167 1 [ [ -LRB- cord-298525-hhcfrjrn 167 2 105 105 CD cord-298525-hhcfrjrn 167 3 ] ] -RRB- cord-298525-hhcfrjrn 167 4 [ [ -LRB- cord-298525-hhcfrjrn 167 5 106 106 CD cord-298525-hhcfrjrn 167 6 ] ] -RRB- cord-298525-hhcfrjrn 167 7 , , , cord-298525-hhcfrjrn 167 8 but but CC cord-298525-hhcfrjrn 167 9 this this DT cord-298525-hhcfrjrn 167 10 is be VBZ cord-298525-hhcfrjrn 167 11 followed follow VBN cord-298525-hhcfrjrn 167 12 by by IN cord-298525-hhcfrjrn 167 13 a a DT cord-298525-hhcfrjrn 167 14 period period NN cord-298525-hhcfrjrn 167 15 of of IN cord-298525-hhcfrjrn 167 16 arrested arrest VBN cord-298525-hhcfrjrn 167 17 maturation maturation NN cord-298525-hhcfrjrn 167 18 after after IN cord-298525-hhcfrjrn 167 19 4 4 CD cord-298525-hhcfrjrn 167 20 years year NNS cord-298525-hhcfrjrn 167 21 of of IN cord-298525-hhcfrjrn 167 22 age age NN cord-298525-hhcfrjrn 167 23 [ [ -LRB- cord-298525-hhcfrjrn 167 24 104 104 CD cord-298525-hhcfrjrn 167 25 , , , cord-298525-hhcfrjrn 167 26 107 107 CD cord-298525-hhcfrjrn 167 27 ] ] -RRB- cord-298525-hhcfrjrn 167 28 , , , cord-298525-hhcfrjrn 167 29 and and CC cord-298525-hhcfrjrn 167 30 then then RB cord-298525-hhcfrjrn 167 31 a a DT cord-298525-hhcfrjrn 167 32 possible possible JJ cord-298525-hhcfrjrn 167 33 decrease decrease NN cord-298525-hhcfrjrn 167 34 in in IN cord-298525-hhcfrjrn 167 35 brain brain NN cord-298525-hhcfrjrn 167 36 volume volume NN cord-298525-hhcfrjrn 167 37 in in IN cord-298525-hhcfrjrn 167 38 older old JJR cord-298525-hhcfrjrn 167 39 children child NNS cord-298525-hhcfrjrn 167 40 and and CC cord-298525-hhcfrjrn 167 41 adults adult NNS cord-298525-hhcfrjrn 167 42 [ [ -LRB- cord-298525-hhcfrjrn 167 43 108 108 CD cord-298525-hhcfrjrn 167 44 ] ] -RRB- cord-298525-hhcfrjrn 167 45 . . . cord-298525-hhcfrjrn 168 1 Therefore therefore RB cord-298525-hhcfrjrn 168 2 , , , cord-298525-hhcfrjrn 168 3 the the DT cord-298525-hhcfrjrn 168 4 hypersensitive hypersensitive JJ cord-298525-hhcfrjrn 168 5 PLR plr NN cord-298525-hhcfrjrn 168 6 observed observe VBN cord-298525-hhcfrjrn 168 7 in in IN cord-298525-hhcfrjrn 168 8 infants infant NNS cord-298525-hhcfrjrn 168 9 with with IN cord-298525-hhcfrjrn 168 10 a a DT cord-298525-hhcfrjrn 168 11 high high JJ cord-298525-hhcfrjrn 168 12 risk risk NN cord-298525-hhcfrjrn 168 13 of of IN cord-298525-hhcfrjrn 168 14 ASD ASD NNP cord-298525-hhcfrjrn 168 15 [ [ -LRB- cord-298525-hhcfrjrn 168 16 100 100 CD cord-298525-hhcfrjrn 168 17 ] ] -RRB- cord-298525-hhcfrjrn 168 18 could could MD cord-298525-hhcfrjrn 168 19 be be VB cord-298525-hhcfrjrn 168 20 attributed attribute VBN cord-298525-hhcfrjrn 168 21 to to IN cord-298525-hhcfrjrn 168 22 the the DT cord-298525-hhcfrjrn 168 23 accelerated accelerated JJ cord-298525-hhcfrjrn 168 24 white white JJ cord-298525-hhcfrjrn 168 25 - - HYPH cord-298525-hhcfrjrn 168 26 matter matter NN cord-298525-hhcfrjrn 168 27 maturation maturation NN cord-298525-hhcfrjrn 168 28 associated associate VBN cord-298525-hhcfrjrn 168 29 with with IN cord-298525-hhcfrjrn 168 30 ASD ASD NNP cord-298525-hhcfrjrn 168 31 , , , cord-298525-hhcfrjrn 168 32 which which WDT cord-298525-hhcfrjrn 168 33 then then RB cord-298525-hhcfrjrn 168 34 reverses reverse VBZ cord-298525-hhcfrjrn 168 35 after after IN cord-298525-hhcfrjrn 168 36 4 4 CD cord-298525-hhcfrjrn 168 37 years year NNS cord-298525-hhcfrjrn 168 38 of of IN cord-298525-hhcfrjrn 168 39 age age NN cord-298525-hhcfrjrn 168 40 , , , cord-298525-hhcfrjrn 168 41 resulting result VBG cord-298525-hhcfrjrn 168 42 in in IN cord-298525-hhcfrjrn 168 43 a a DT cord-298525-hhcfrjrn 168 44 hyposensitive hyposensitive JJ cord-298525-hhcfrjrn 168 45 PLR plr NN cord-298525-hhcfrjrn 168 46 response response NN cord-298525-hhcfrjrn 168 47 corresponding correspond VBG cord-298525-hhcfrjrn 168 48 to to IN cord-298525-hhcfrjrn 168 49 the the DT cord-298525-hhcfrjrn 168 50 reduction reduction NN cord-298525-hhcfrjrn 168 51 in in IN cord-298525-hhcfrjrn 168 52 PLR plr NN cord-298525-hhcfrjrn 168 53 parameters parameter NNS cord-298525-hhcfrjrn 168 54 [ [ -LRB- cord-298525-hhcfrjrn 168 55 61 61 CD cord-298525-hhcfrjrn 168 56 , , , cord-298525-hhcfrjrn 168 57 98 98 CD cord-298525-hhcfrjrn 168 58 , , , cord-298525-hhcfrjrn 168 59 99 99 CD cord-298525-hhcfrjrn 168 60 ] ] -RRB- cord-298525-hhcfrjrn 168 61 . . . cord-298525-hhcfrjrn 169 1 There there EX cord-298525-hhcfrjrn 169 2 is be VBZ cord-298525-hhcfrjrn 169 3 evidence evidence NN cord-298525-hhcfrjrn 169 4 to to TO cord-298525-hhcfrjrn 169 5 suggest suggest VB cord-298525-hhcfrjrn 169 6 that that IN cord-298525-hhcfrjrn 169 7 , , , cord-298525-hhcfrjrn 169 8 apart apart RB cord-298525-hhcfrjrn 169 9 from from IN cord-298525-hhcfrjrn 169 10 the the DT cord-298525-hhcfrjrn 169 11 cholinergic cholinergic JJ cord-298525-hhcfrjrn 169 12 system system NN cord-298525-hhcfrjrn 169 13 , , , cord-298525-hhcfrjrn 169 14 other other JJ cord-298525-hhcfrjrn 169 15 neurotransmitter neurotransmitter NN cord-298525-hhcfrjrn 169 16 systems system NNS cord-298525-hhcfrjrn 169 17 are be VBP cord-298525-hhcfrjrn 169 18 altered alter VBN cord-298525-hhcfrjrn 169 19 in in IN cord-298525-hhcfrjrn 169 20 ASD ASD NNP cord-298525-hhcfrjrn 169 21 , , , cord-298525-hhcfrjrn 169 22 such such JJ cord-298525-hhcfrjrn 169 23 as as IN cord-298525-hhcfrjrn 169 24 glutamatergic glutamatergic JJ cord-298525-hhcfrjrn 169 25 and and CC cord-298525-hhcfrjrn 169 26 GABAergic gabaergic NN cord-298525-hhcfrjrn 169 27 transmission transmission NN cord-298525-hhcfrjrn 169 28 [ [ -LRB- cord-298525-hhcfrjrn 169 29 109 109 CD cord-298525-hhcfrjrn 169 30 ] ] -RRB- cord-298525-hhcfrjrn 169 31 . . . cord-298525-hhcfrjrn 170 1 Therefore therefore RB cord-298525-hhcfrjrn 170 2 , , , cord-298525-hhcfrjrn 170 3 the the DT cord-298525-hhcfrjrn 170 4 PLR plr NN cord-298525-hhcfrjrn 170 5 may may MD cord-298525-hhcfrjrn 170 6 also also RB cord-298525-hhcfrjrn 170 7 be be VB cord-298525-hhcfrjrn 170 8 affected affect VBN cord-298525-hhcfrjrn 170 9 as as IN cord-298525-hhcfrjrn 170 10 a a DT cord-298525-hhcfrjrn 170 11 result result NN cord-298525-hhcfrjrn 170 12 of of IN cord-298525-hhcfrjrn 170 13 altered alter VBN cord-298525-hhcfrjrn 170 14 bipolar bipolar JJ cord-298525-hhcfrjrn 170 15 cell cell NN cord-298525-hhcfrjrn 170 16 signalling signal VBG cord-298525-hhcfrjrn 170 17 within within IN cord-298525-hhcfrjrn 170 18 the the DT cord-298525-hhcfrjrn 170 19 retina retina NN cord-298525-hhcfrjrn 170 20 . . . cord-298525-hhcfrjrn 171 1 Overall overall RB cord-298525-hhcfrjrn 171 2 , , , cord-298525-hhcfrjrn 171 3 assessment assessment NN cord-298525-hhcfrjrn 171 4 of of IN cord-298525-hhcfrjrn 171 5 the the DT cord-298525-hhcfrjrn 171 6 PLR PLR NNP cord-298525-hhcfrjrn 171 7 by by IN cord-298525-hhcfrjrn 171 8 pupillometry pupillometry NNP cord-298525-hhcfrjrn 171 9 may may MD cord-298525-hhcfrjrn 171 10 provide provide VB cord-298525-hhcfrjrn 171 11 a a DT cord-298525-hhcfrjrn 171 12 rapid rapid JJ cord-298525-hhcfrjrn 171 13 and and CC cord-298525-hhcfrjrn 171 14 non non JJ cord-298525-hhcfrjrn 171 15 - - JJ cord-298525-hhcfrjrn 171 16 invasive invasive JJ cord-298525-hhcfrjrn 171 17 diagnostic diagnostic JJ cord-298525-hhcfrjrn 171 18 tool tool NN cord-298525-hhcfrjrn 171 19 for for IN cord-298525-hhcfrjrn 171 20 infants infant NNS cord-298525-hhcfrjrn 171 21 and and CC cord-298525-hhcfrjrn 171 22 children child NNS cord-298525-hhcfrjrn 171 23 with with IN cord-298525-hhcfrjrn 171 24 a a DT cord-298525-hhcfrjrn 171 25 high high JJ cord-298525-hhcfrjrn 171 26 risk risk NN cord-298525-hhcfrjrn 171 27 of of IN cord-298525-hhcfrjrn 171 28 ASD ASD NNP cord-298525-hhcfrjrn 171 29 or or CC cord-298525-hhcfrjrn 171 30 other other JJ cord-298525-hhcfrjrn 171 31 cholinergic cholinergic JJ cord-298525-hhcfrjrn 171 32 - - HYPH cord-298525-hhcfrjrn 171 33 dependent dependent JJ cord-298525-hhcfrjrn 171 34 neurological neurological JJ cord-298525-hhcfrjrn 171 35 development development NN cord-298525-hhcfrjrn 171 36 disorders disorder NNS cord-298525-hhcfrjrn 171 37 [ [ -LRB- cord-298525-hhcfrjrn 171 38 100 100 CD cord-298525-hhcfrjrn 171 39 ] ] -RRB- cord-298525-hhcfrjrn 171 40 . . . cord-298525-hhcfrjrn 172 1 Pupillometry Pupillometry NNP cord-298525-hhcfrjrn 172 2 offers offer VBZ cord-298525-hhcfrjrn 172 3 a a DT cord-298525-hhcfrjrn 172 4 reliable reliable JJ cord-298525-hhcfrjrn 172 5 and and CC cord-298525-hhcfrjrn 172 6 convenient convenient JJ cord-298525-hhcfrjrn 172 7 tool tool NN cord-298525-hhcfrjrn 172 8 for for IN cord-298525-hhcfrjrn 172 9 illicit illicit JJ cord-298525-hhcfrjrn 172 10 drug drug NN cord-298525-hhcfrjrn 172 11 and and CC cord-298525-hhcfrjrn 172 12 alcohol alcohol NN cord-298525-hhcfrjrn 172 13 screening screening NN cord-298525-hhcfrjrn 172 14 [ [ -LRB- cord-298525-hhcfrjrn 172 15 110 110 CD cord-298525-hhcfrjrn 172 16 ] ] -RRB- cord-298525-hhcfrjrn 172 17 [ [ -LRB- cord-298525-hhcfrjrn 172 18 111 111 CD cord-298525-hhcfrjrn 172 19 ] ] -RRB- cord-298525-hhcfrjrn 172 20 [ [ -LRB- cord-298525-hhcfrjrn 172 21 112 112 CD cord-298525-hhcfrjrn 172 22 ] ] -RRB- cord-298525-hhcfrjrn 172 23 . . . cord-298525-hhcfrjrn 173 1 A a DT cord-298525-hhcfrjrn 173 2 number number NN cord-298525-hhcfrjrn 173 3 of of IN cord-298525-hhcfrjrn 173 4 studies study NNS cord-298525-hhcfrjrn 173 5 have have VBP cord-298525-hhcfrjrn 173 6 demonstrated demonstrate VBN cord-298525-hhcfrjrn 173 7 the the DT cord-298525-hhcfrjrn 173 8 ability ability NN cord-298525-hhcfrjrn 173 9 of of IN cord-298525-hhcfrjrn 173 10 pupillometry pupillometry NN cord-298525-hhcfrjrn 173 11 to to TO cord-298525-hhcfrjrn 173 12 differentiate differentiate VB cord-298525-hhcfrjrn 173 13 between between IN cord-298525-hhcfrjrn 173 14 potentially potentially RB cord-298525-hhcfrjrn 173 15 drug drug NN cord-298525-hhcfrjrn 173 16 impaired impair VBN cord-298525-hhcfrjrn 173 17 and and CC cord-298525-hhcfrjrn 173 18 normal normal JJ cord-298525-hhcfrjrn 173 19 subjects subject NNS cord-298525-hhcfrjrn 173 20 with with IN cord-298525-hhcfrjrn 173 21 70 70 CD cord-298525-hhcfrjrn 173 22 - - SYM cord-298525-hhcfrjrn 173 23 100 100 CD cord-298525-hhcfrjrn 173 24 % % NN cord-298525-hhcfrjrn 173 25 accuracy accuracy NN cord-298525-hhcfrjrn 173 26 [ [ -LRB- cord-298525-hhcfrjrn 173 27 113 113 CD cord-298525-hhcfrjrn 173 28 , , , cord-298525-hhcfrjrn 173 29 114 114 CD cord-298525-hhcfrjrn 173 30 ] ] -RRB- cord-298525-hhcfrjrn 173 31 . . . cord-298525-hhcfrjrn 174 1 The the DT cord-298525-hhcfrjrn 174 2 most most RBS cord-298525-hhcfrjrn 174 3 significant significant JJ cord-298525-hhcfrjrn 174 4 parameters parameter NNS cord-298525-hhcfrjrn 174 5 were be VBD cord-298525-hhcfrjrn 174 6 RPA RPA NNP cord-298525-hhcfrjrn 174 7 and and CC cord-298525-hhcfrjrn 174 8 MCV MCV NNP cord-298525-hhcfrjrn 174 9 [ [ -LRB- cord-298525-hhcfrjrn 174 10 112 112 CD cord-298525-hhcfrjrn 174 11 ] ] -RRB- cord-298525-hhcfrjrn 174 12 . . . cord-298525-hhcfrjrn 175 1 Additionally additionally RB cord-298525-hhcfrjrn 175 2 , , , cord-298525-hhcfrjrn 175 3 pupillometry pupillometry NNP cord-298525-hhcfrjrn 175 4 may may MD cord-298525-hhcfrjrn 175 5 offer offer VB cord-298525-hhcfrjrn 175 6 benefits benefit NNS cord-298525-hhcfrjrn 175 7 over over IN cord-298525-hhcfrjrn 175 8 urinalysis urinalysis NN cord-298525-hhcfrjrn 175 9 , , , cord-298525-hhcfrjrn 175 10 particularly particularly RB cord-298525-hhcfrjrn 175 11 in in IN cord-298525-hhcfrjrn 175 12 the the DT cord-298525-hhcfrjrn 175 13 case case NN cord-298525-hhcfrjrn 175 14 of of IN cord-298525-hhcfrjrn 175 15 roadside roadside NN cord-298525-hhcfrjrn 175 16 testing testing NN cord-298525-hhcfrjrn 175 17 , , , cord-298525-hhcfrjrn 175 18 as as IN cord-298525-hhcfrjrn 175 19 it -PRON- PRP cord-298525-hhcfrjrn 175 20 provides provide VBZ cord-298525-hhcfrjrn 175 21 a a DT cord-298525-hhcfrjrn 175 22 measurement measurement NN cord-298525-hhcfrjrn 175 23 of of IN cord-298525-hhcfrjrn 175 24 function function NN cord-298525-hhcfrjrn 175 25 and and CC cord-298525-hhcfrjrn 175 26 impairment impairment NN cord-298525-hhcfrjrn 175 27 rather rather RB cord-298525-hhcfrjrn 175 28 than than IN cord-298525-hhcfrjrn 175 29 a a DT cord-298525-hhcfrjrn 175 30 measurement measurement NN cord-298525-hhcfrjrn 175 31 of of IN cord-298525-hhcfrjrn 175 32 drug drug NN cord-298525-hhcfrjrn 175 33 metabolites metabolite NNS cord-298525-hhcfrjrn 175 34 , , , cord-298525-hhcfrjrn 175 35 which which WDT cord-298525-hhcfrjrn 175 36 may may MD cord-298525-hhcfrjrn 175 37 be be VB cord-298525-hhcfrjrn 175 38 present present JJ cord-298525-hhcfrjrn 175 39 in in IN cord-298525-hhcfrjrn 175 40 the the DT cord-298525-hhcfrjrn 175 41 urine urine NN cord-298525-hhcfrjrn 175 42 for for IN cord-298525-hhcfrjrn 175 43 an an DT cord-298525-hhcfrjrn 175 44 extended extended JJ cord-298525-hhcfrjrn 175 45 period period NN cord-298525-hhcfrjrn 175 46 even even RB cord-298525-hhcfrjrn 175 47 though though IN cord-298525-hhcfrjrn 175 48 any any DT cord-298525-hhcfrjrn 175 49 drug drug NN cord-298525-hhcfrjrn 175 50 - - HYPH cord-298525-hhcfrjrn 175 51 induced induce VBN cord-298525-hhcfrjrn 175 52 physiological physiological JJ cord-298525-hhcfrjrn 175 53 effects effect NNS cord-298525-hhcfrjrn 175 54 or or CC cord-298525-hhcfrjrn 175 55 impairment impairment NN cord-298525-hhcfrjrn 175 56 have have VBP cord-298525-hhcfrjrn 175 57 ceased cease VBN cord-298525-hhcfrjrn 175 58 . . . cord-298525-hhcfrjrn 176 1 Pupillometry Pupillometry NNP cord-298525-hhcfrjrn 176 2 may may MD cord-298525-hhcfrjrn 176 3 have have VB cord-298525-hhcfrjrn 176 4 a a DT cord-298525-hhcfrjrn 176 5 role role NN cord-298525-hhcfrjrn 176 6 in in IN cord-298525-hhcfrjrn 176 7 both both CC cord-298525-hhcfrjrn 176 8 the the DT cord-298525-hhcfrjrn 176 9 detection detection NN cord-298525-hhcfrjrn 176 10 of of IN cord-298525-hhcfrjrn 176 11 alcohol alcohol NN cord-298525-hhcfrjrn 176 12 intoxication intoxication NN cord-298525-hhcfrjrn 176 13 and and CC cord-298525-hhcfrjrn 176 14 treatment treatment NN cord-298525-hhcfrjrn 176 15 management management NN cord-298525-hhcfrjrn 176 16 during during IN cord-298525-hhcfrjrn 176 17 alcohol alcohol NN cord-298525-hhcfrjrn 176 18 withdrawal withdrawal NN cord-298525-hhcfrjrn 176 19 . . . cord-298525-hhcfrjrn 177 1 Data datum NNS cord-298525-hhcfrjrn 177 2 from from IN cord-298525-hhcfrjrn 177 3 chromatic chromatic JJ cord-298525-hhcfrjrn 177 4 pupillometry pupillometry NNP cord-298525-hhcfrjrn 177 5 studies study NNS cord-298525-hhcfrjrn 177 6 demonstrated demonstrate VBD cord-298525-hhcfrjrn 177 7 a a DT cord-298525-hhcfrjrn 177 8 significant significant JJ cord-298525-hhcfrjrn 177 9 increase increase NN cord-298525-hhcfrjrn 177 10 in in IN cord-298525-hhcfrjrn 177 11 both both CC cord-298525-hhcfrjrn 177 12 baseline baseline JJ cord-298525-hhcfrjrn 177 13 pupil pupil NN cord-298525-hhcfrjrn 177 14 diameter diameter NN cord-298525-hhcfrjrn 177 15 and and CC cord-298525-hhcfrjrn 177 16 peak peak NN cord-298525-hhcfrjrn 177 17 constriction constriction NN cord-298525-hhcfrjrn 177 18 amplitude amplitude NN cord-298525-hhcfrjrn 177 19 following follow VBG cord-298525-hhcfrjrn 177 20 a a DT cord-298525-hhcfrjrn 177 21 600 600 CD cord-298525-hhcfrjrn 177 22 nm nm NN cord-298525-hhcfrjrn 177 23 wavelength wavelength NN cord-298525-hhcfrjrn 177 24 light light JJ cord-298525-hhcfrjrn 177 25 stimulus stimulus NN cord-298525-hhcfrjrn 177 26 at at IN cord-298525-hhcfrjrn 177 27 exhaled exhale VBN cord-298525-hhcfrjrn 177 28 breath breath NN cord-298525-hhcfrjrn 177 29 alcohol alcohol NN cord-298525-hhcfrjrn 177 30 concentrations concentration NNS cord-298525-hhcfrjrn 177 31 of of IN cord-298525-hhcfrjrn 177 32 ≥0.25 ≥0.25 CD cord-298525-hhcfrjrn 178 1 mg mg NNP cord-298525-hhcfrjrn 178 2 / / SYM cord-298525-hhcfrjrn 178 3 L L NNP cord-298525-hhcfrjrn 178 4 [ [ -LRB- cord-298525-hhcfrjrn 178 5 115 115 CD cord-298525-hhcfrjrn 178 6 ] ] -RRB- cord-298525-hhcfrjrn 178 7 . . . cord-298525-hhcfrjrn 179 1 However however RB cord-298525-hhcfrjrn 179 2 , , , cord-298525-hhcfrjrn 179 3 following follow VBG cord-298525-hhcfrjrn 179 4 a a DT cord-298525-hhcfrjrn 179 5 high high JJ cord-298525-hhcfrjrn 179 6 dose dose NN cord-298525-hhcfrjrn 179 7 of of IN cord-298525-hhcfrjrn 179 8 alcohol alcohol NN cord-298525-hhcfrjrn 179 9 ( ( -LRB- cord-298525-hhcfrjrn 179 10 1 1 CD cord-298525-hhcfrjrn 179 11 g g NN cord-298525-hhcfrjrn 179 12 / / SYM cord-298525-hhcfrjrn 179 13 kg kg NN cord-298525-hhcfrjrn 179 14 body body NN cord-298525-hhcfrjrn 179 15 weight weight NN cord-298525-hhcfrjrn 179 16 ) ) -RRB- cord-298525-hhcfrjrn 179 17 the the DT cord-298525-hhcfrjrn 179 18 opposite opposite NN cord-298525-hhcfrjrn 179 19 was be VBD cord-298525-hhcfrjrn 179 20 observed observe VBN cord-298525-hhcfrjrn 179 21 , , , cord-298525-hhcfrjrn 179 22 with with IN cord-298525-hhcfrjrn 179 23 significant significant JJ cord-298525-hhcfrjrn 179 24 decreases decrease NNS cord-298525-hhcfrjrn 179 25 in in IN cord-298525-hhcfrjrn 179 26 pupil pupil NN cord-298525-hhcfrjrn 179 27 diameter diameter NN cord-298525-hhcfrjrn 179 28 , , , cord-298525-hhcfrjrn 179 29 constriction constriction NN cord-298525-hhcfrjrn 179 30 amplitude amplitude NN cord-298525-hhcfrjrn 179 31 and and CC cord-298525-hhcfrjrn 179 32 velocity velocity NN cord-298525-hhcfrjrn 179 33 compared compare VBN cord-298525-hhcfrjrn 179 34 to to IN cord-298525-hhcfrjrn 179 35 control control NN cord-298525-hhcfrjrn 179 36 groups group NNS cord-298525-hhcfrjrn 179 37 , , , cord-298525-hhcfrjrn 179 38 suggesting suggest VBG cord-298525-hhcfrjrn 179 39 inhibition inhibition NN cord-298525-hhcfrjrn 179 40 of of IN cord-298525-hhcfrjrn 179 41 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 179 42 nerve nerve NN cord-298525-hhcfrjrn 179 43 activity activity NN cord-298525-hhcfrjrn 179 44 [ [ -LRB- cord-298525-hhcfrjrn 179 45 116 116 CD cord-298525-hhcfrjrn 179 46 , , , cord-298525-hhcfrjrn 179 47 117 117 CD cord-298525-hhcfrjrn 179 48 ] ] -RRB- cord-298525-hhcfrjrn 179 49 . . . cord-298525-hhcfrjrn 180 1 These these DT cord-298525-hhcfrjrn 180 2 apparently apparently RB cord-298525-hhcfrjrn 180 3 contradictory contradictory JJ cord-298525-hhcfrjrn 180 4 results result NNS cord-298525-hhcfrjrn 180 5 are be VBP cord-298525-hhcfrjrn 180 6 likely likely JJ cord-298525-hhcfrjrn 180 7 to to TO cord-298525-hhcfrjrn 180 8 reflect reflect VB cord-298525-hhcfrjrn 180 9 the the DT cord-298525-hhcfrjrn 180 10 acute acute JJ cord-298525-hhcfrjrn 180 11 , , , cord-298525-hhcfrjrn 180 12 dose dose NN cord-298525-hhcfrjrn 180 13 - - HYPH cord-298525-hhcfrjrn 180 14 dependent dependent JJ cord-298525-hhcfrjrn 180 15 inhibition inhibition NN cord-298525-hhcfrjrn 180 16 of of IN cord-298525-hhcfrjrn 180 17 the the DT cord-298525-hhcfrjrn 180 18 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 180 19 nervous nervous JJ cord-298525-hhcfrjrn 180 20 system system NN cord-298525-hhcfrjrn 180 21 , , , cord-298525-hhcfrjrn 180 22 which which WDT cord-298525-hhcfrjrn 180 23 results result VBZ cord-298525-hhcfrjrn 180 24 in in IN cord-298525-hhcfrjrn 180 25 the the DT cord-298525-hhcfrjrn 180 26 predominance predominance NN cord-298525-hhcfrjrn 180 27 of of IN cord-298525-hhcfrjrn 180 28 sympathetic sympathetic JJ cord-298525-hhcfrjrn 180 29 nerve nerve NN cord-298525-hhcfrjrn 180 30 activity activity NN cord-298525-hhcfrjrn 180 31 [ [ -LRB- cord-298525-hhcfrjrn 180 32 118 118 CD cord-298525-hhcfrjrn 180 33 ] ] -RRB- cord-298525-hhcfrjrn 180 34 . . . cord-298525-hhcfrjrn 181 1 Pupillometry Pupillometry NNP cord-298525-hhcfrjrn 181 2 may may MD cord-298525-hhcfrjrn 181 3 also also RB cord-298525-hhcfrjrn 181 4 have have VB cord-298525-hhcfrjrn 181 5 a a DT cord-298525-hhcfrjrn 181 6 role role NN cord-298525-hhcfrjrn 181 7 in in IN cord-298525-hhcfrjrn 181 8 the the DT cord-298525-hhcfrjrn 181 9 development development NN cord-298525-hhcfrjrn 181 10 of of IN cord-298525-hhcfrjrn 181 11 clinical clinical JJ cord-298525-hhcfrjrn 181 12 management management NN cord-298525-hhcfrjrn 181 13 tools tool NNS cord-298525-hhcfrjrn 181 14 to to TO cord-298525-hhcfrjrn 181 15 prevent prevent VB cord-298525-hhcfrjrn 181 16 severe severe JJ cord-298525-hhcfrjrn 181 17 autonomic autonomic JJ cord-298525-hhcfrjrn 181 18 dysfunction dysfunction NN cord-298525-hhcfrjrn 181 19 during during IN cord-298525-hhcfrjrn 181 20 alcohol alcohol NN cord-298525-hhcfrjrn 181 21 withdrawal withdrawal NN cord-298525-hhcfrjrn 181 22 [ [ -LRB- cord-298525-hhcfrjrn 181 23 119 119 CD cord-298525-hhcfrjrn 181 24 ] ] -RRB- cord-298525-hhcfrjrn 181 25 . . . cord-298525-hhcfrjrn 182 1 Specifically specifically RB cord-298525-hhcfrjrn 182 2 , , , cord-298525-hhcfrjrn 182 3 prolonged prolonged JJ cord-298525-hhcfrjrn 182 4 latency latency NN cord-298525-hhcfrjrn 182 5 and and CC cord-298525-hhcfrjrn 182 6 decreased decrease VBD cord-298525-hhcfrjrn 182 7 constriction constriction NN cord-298525-hhcfrjrn 182 8 velocity velocity NN cord-298525-hhcfrjrn 182 9 parameters parameter NNS cord-298525-hhcfrjrn 182 10 were be VBD cord-298525-hhcfrjrn 182 11 described describe VBN cord-298525-hhcfrjrn 182 12 for for IN cord-298525-hhcfrjrn 182 13 participants participant NNS cord-298525-hhcfrjrn 182 14 undergoing undergo VBG cord-298525-hhcfrjrn 182 15 alcohol alcohol NN cord-298525-hhcfrjrn 182 16 withdrawal withdrawal NN cord-298525-hhcfrjrn 182 17 . . . cord-298525-hhcfrjrn 183 1 The the DT cord-298525-hhcfrjrn 183 2 reduction reduction NN cord-298525-hhcfrjrn 183 3 in in IN cord-298525-hhcfrjrn 183 4 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 183 5 innervation innervation NN cord-298525-hhcfrjrn 183 6 of of IN cord-298525-hhcfrjrn 183 7 the the DT cord-298525-hhcfrjrn 183 8 pupil pupil NN cord-298525-hhcfrjrn 183 9 is be VBZ cord-298525-hhcfrjrn 183 10 likely likely JJ cord-298525-hhcfrjrn 183 11 to to TO cord-298525-hhcfrjrn 183 12 be be VB cord-298525-hhcfrjrn 183 13 due due JJ cord-298525-hhcfrjrn 183 14 to to IN cord-298525-hhcfrjrn 183 15 increased increase VBN cord-298525-hhcfrjrn 183 16 activation activation NN cord-298525-hhcfrjrn 183 17 of of IN cord-298525-hhcfrjrn 183 18 the the DT cord-298525-hhcfrjrn 183 19 locus locus NN cord-298525-hhcfrjrn 183 20 coeruleus coeruleu VBZ cord-298525-hhcfrjrn 183 21 , , , cord-298525-hhcfrjrn 183 22 as as IN cord-298525-hhcfrjrn 183 23 previously previously RB cord-298525-hhcfrjrn 183 24 described describe VBN cord-298525-hhcfrjrn 183 25 during during IN cord-298525-hhcfrjrn 183 26 alcohol alcohol NN cord-298525-hhcfrjrn 183 27 withdrawal withdrawal NN cord-298525-hhcfrjrn 183 28 [ [ -LRB- cord-298525-hhcfrjrn 183 29 120 120 CD cord-298525-hhcfrjrn 183 30 , , , cord-298525-hhcfrjrn 183 31 121 121 CD cord-298525-hhcfrjrn 183 32 ] ] -RRB- cord-298525-hhcfrjrn 183 33 . . . cord-298525-hhcfrjrn 184 1 The the DT cord-298525-hhcfrjrn 184 2 pupillary pupillary JJ cord-298525-hhcfrjrn 184 3 response response NN cord-298525-hhcfrjrn 184 4 to to IN cord-298525-hhcfrjrn 184 5 3,4 3,4 CD cord-298525-hhcfrjrn 184 6 methylenedioxymethamphetamine methylenedioxymethamphetamine NN cord-298525-hhcfrjrn 184 7 ( ( -LRB- cord-298525-hhcfrjrn 184 8 MDMA MDMA NNP cord-298525-hhcfrjrn 184 9 ) ) -RRB- cord-298525-hhcfrjrn 184 10 and and CC cord-298525-hhcfrjrn 184 11 tetrahydrocannabinol tetrahydrocannabinol NN cord-298525-hhcfrjrn 184 12 ( ( -LRB- cord-298525-hhcfrjrn 184 13 cannabis cannabis NN cord-298525-hhcfrjrn 184 14 ) ) -RRB- cord-298525-hhcfrjrn 184 15 is be VBZ cord-298525-hhcfrjrn 184 16 characterised characterise VBN cord-298525-hhcfrjrn 184 17 by by IN cord-298525-hhcfrjrn 184 18 an an DT cord-298525-hhcfrjrn 184 19 indirect indirect JJ cord-298525-hhcfrjrn 184 20 central central JJ cord-298525-hhcfrjrn 184 21 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 184 22 inhibition inhibition NN cord-298525-hhcfrjrn 184 23 , , , cord-298525-hhcfrjrn 184 24 resulting result VBG cord-298525-hhcfrjrn 184 25 in in IN cord-298525-hhcfrjrn 184 26 significantly significantly RB cord-298525-hhcfrjrn 184 27 increased increase VBN cord-298525-hhcfrjrn 184 28 latency latency NN cord-298525-hhcfrjrn 184 29 and and CC cord-298525-hhcfrjrn 184 30 decreased decrease VBD cord-298525-hhcfrjrn 184 31 constriction constriction NN cord-298525-hhcfrjrn 184 32 amplitude amplitude NN cord-298525-hhcfrjrn 184 33 and and CC cord-298525-hhcfrjrn 184 34 velocity velocity NN cord-298525-hhcfrjrn 184 35 [ [ -LRB- cord-298525-hhcfrjrn 184 36 113 113 CD cord-298525-hhcfrjrn 184 37 , , , cord-298525-hhcfrjrn 184 38 122 122 CD cord-298525-hhcfrjrn 184 39 , , , cord-298525-hhcfrjrn 184 40 123 123 CD cord-298525-hhcfrjrn 184 41 ] ] -RRB- cord-298525-hhcfrjrn 184 42 . . . cord-298525-hhcfrjrn 185 1 Additionally additionally RB cord-298525-hhcfrjrn 185 2 , , , cord-298525-hhcfrjrn 185 3 increased increase VBN cord-298525-hhcfrjrn 185 4 sympathomimetic sympathomimetic JJ cord-298525-hhcfrjrn 185 5 activity activity NN cord-298525-hhcfrjrn 185 6 due due JJ cord-298525-hhcfrjrn 185 7 to to IN cord-298525-hhcfrjrn 185 8 increased increase VBN cord-298525-hhcfrjrn 185 9 noradrenaline noradrenaline NN cord-298525-hhcfrjrn 185 10 and and CC cord-298525-hhcfrjrn 185 11 serotonin serotonin NN cord-298525-hhcfrjrn 185 12 signalling signalling NN cord-298525-hhcfrjrn 185 13 was be VBD cord-298525-hhcfrjrn 185 14 reported report VBN cord-298525-hhcfrjrn 185 15 following follow VBG cord-298525-hhcfrjrn 185 16 MDMA MDMA NNP cord-298525-hhcfrjrn 185 17 intoxication intoxication NN cord-298525-hhcfrjrn 185 18 , , , cord-298525-hhcfrjrn 185 19 resulting result VBG cord-298525-hhcfrjrn 185 20 in in IN cord-298525-hhcfrjrn 185 21 mydriasis mydriasis NN cord-298525-hhcfrjrn 185 22 and and CC cord-298525-hhcfrjrn 185 23 a a DT cord-298525-hhcfrjrn 185 24 reduction reduction NN cord-298525-hhcfrjrn 185 25 in in IN cord-298525-hhcfrjrn 185 26 the the DT cord-298525-hhcfrjrn 185 27 PLR plr NN cord-298525-hhcfrjrn 185 28 recovery recovery NN cord-298525-hhcfrjrn 185 29 time time NN cord-298525-hhcfrjrn 185 30 [ [ -LRB- cord-298525-hhcfrjrn 185 31 123 123 CD cord-298525-hhcfrjrn 185 32 ] ] -RRB- cord-298525-hhcfrjrn 185 33 . . . cord-298525-hhcfrjrn 186 1 However however RB cord-298525-hhcfrjrn 186 2 , , , cord-298525-hhcfrjrn 186 3 for for IN cord-298525-hhcfrjrn 186 4 cannabis cannabis NN cord-298525-hhcfrjrn 186 5 intoxication intoxication NN cord-298525-hhcfrjrn 186 6 there there EX cord-298525-hhcfrjrn 186 7 are be VBP cord-298525-hhcfrjrn 186 8 conflicting conflict VBG cord-298525-hhcfrjrn 186 9 reports report NNS cord-298525-hhcfrjrn 186 10 regarding regard VBG cord-298525-hhcfrjrn 186 11 the the DT cord-298525-hhcfrjrn 186 12 effect effect NN cord-298525-hhcfrjrn 186 13 of of IN cord-298525-hhcfrjrn 186 14 the the DT cord-298525-hhcfrjrn 186 15 drug drug NN cord-298525-hhcfrjrn 186 16 on on IN cord-298525-hhcfrjrn 186 17 baseline baseline JJ cord-298525-hhcfrjrn 186 18 pupil pupil NN cord-298525-hhcfrjrn 186 19 diameter diameter NN cord-298525-hhcfrjrn 186 20 . . . cord-298525-hhcfrjrn 187 1 Hartman Hartman NNP cord-298525-hhcfrjrn 187 2 et et NNP cord-298525-hhcfrjrn 187 3 al al NNP cord-298525-hhcfrjrn 187 4 . . . cord-298525-hhcfrjrn 188 1 observed observe VBD cord-298525-hhcfrjrn 188 2 a a DT cord-298525-hhcfrjrn 188 3 significantly significantly RB cord-298525-hhcfrjrn 188 4 increased increase VBN cord-298525-hhcfrjrn 188 5 pupil pupil NN cord-298525-hhcfrjrn 188 6 size size NN cord-298525-hhcfrjrn 188 7 compared compare VBN cord-298525-hhcfrjrn 188 8 to to TO cord-298525-hhcfrjrn 188 9 control control VB cord-298525-hhcfrjrn 188 10 participants participant NNS cord-298525-hhcfrjrn 188 11 , , , cord-298525-hhcfrjrn 188 12 under under IN cord-298525-hhcfrjrn 188 13 both both DT cord-298525-hhcfrjrn 188 14 scotopic scotopic NNP cord-298525-hhcfrjrn 188 15 and and CC cord-298525-hhcfrjrn 188 16 photopic photopic JJ cord-298525-hhcfrjrn 188 17 light light JJ cord-298525-hhcfrjrn 188 18 conditions condition NNS cord-298525-hhcfrjrn 188 19 as as RB cord-298525-hhcfrjrn 188 20 well well RB cord-298525-hhcfrjrn 188 21 as as IN cord-298525-hhcfrjrn 188 22 following follow VBG cord-298525-hhcfrjrn 188 23 direct direct JJ cord-298525-hhcfrjrn 188 24 light light JJ cord-298525-hhcfrjrn 188 25 stimulation stimulation NN cord-298525-hhcfrjrn 188 26 , , , cord-298525-hhcfrjrn 188 27 suggesting suggest VBG cord-298525-hhcfrjrn 188 28 increased increase VBN cord-298525-hhcfrjrn 188 29 sympathetic sympathetic JJ cord-298525-hhcfrjrn 188 30 nervous nervous JJ cord-298525-hhcfrjrn 188 31 system system NN cord-298525-hhcfrjrn 188 32 activity activity NN cord-298525-hhcfrjrn 188 33 [ [ -LRB- cord-298525-hhcfrjrn 188 34 112 112 CD cord-298525-hhcfrjrn 188 35 ] ] -RRB- cord-298525-hhcfrjrn 188 36 . . . cord-298525-hhcfrjrn 189 1 This this DT cord-298525-hhcfrjrn 189 2 is be VBZ cord-298525-hhcfrjrn 189 3 in in IN cord-298525-hhcfrjrn 189 4 contrast contrast NN cord-298525-hhcfrjrn 189 5 to to IN cord-298525-hhcfrjrn 189 6 data datum NNS cord-298525-hhcfrjrn 189 7 reported report VBN cord-298525-hhcfrjrn 189 8 by by IN cord-298525-hhcfrjrn 189 9 Fant Fant NNP cord-298525-hhcfrjrn 189 10 et et NNP cord-298525-hhcfrjrn 189 11 al al NNP cord-298525-hhcfrjrn 189 12 . . . cord-298525-hhcfrjrn 190 1 and and CC cord-298525-hhcfrjrn 190 2 others other NNS cord-298525-hhcfrjrn 190 3 , , , cord-298525-hhcfrjrn 190 4 which which WDT cord-298525-hhcfrjrn 190 5 demonstrated demonstrate VBD cord-298525-hhcfrjrn 190 6 a a DT cord-298525-hhcfrjrn 190 7 significant significant JJ cord-298525-hhcfrjrn 190 8 cannabis cannabis NN cord-298525-hhcfrjrn 190 9 - - HYPH cord-298525-hhcfrjrn 190 10 induced induce VBN cord-298525-hhcfrjrn 190 11 effect effect NN cord-298525-hhcfrjrn 190 12 on on IN cord-298525-hhcfrjrn 190 13 the the DT cord-298525-hhcfrjrn 190 14 PLR plr NN cord-298525-hhcfrjrn 190 15 but but CC cord-298525-hhcfrjrn 190 16 either either CC cord-298525-hhcfrjrn 190 17 a a DT cord-298525-hhcfrjrn 190 18 small small JJ cord-298525-hhcfrjrn 190 19 ( ( -LRB- cord-298525-hhcfrjrn 190 20 0.5 0.5 CD cord-298525-hhcfrjrn 190 21 mm mm NN cord-298525-hhcfrjrn 190 22 ) ) -RRB- cord-298525-hhcfrjrn 190 23 decrease decrease VB cord-298525-hhcfrjrn 190 24 [ [ -LRB- cord-298525-hhcfrjrn 190 25 116 116 CD cord-298525-hhcfrjrn 190 26 , , , cord-298525-hhcfrjrn 190 27 124 124 CD cord-298525-hhcfrjrn 190 28 ] ] -RRB- cord-298525-hhcfrjrn 190 29 or or CC cord-298525-hhcfrjrn 190 30 no no DT cord-298525-hhcfrjrn 190 31 change change NN cord-298525-hhcfrjrn 190 32 [ [ -LRB- cord-298525-hhcfrjrn 190 33 122 122 CD cord-298525-hhcfrjrn 190 34 ] ] -RRB- cord-298525-hhcfrjrn 190 35 in in IN cord-298525-hhcfrjrn 190 36 baseline baseline JJ cord-298525-hhcfrjrn 190 37 pupil pupil NN cord-298525-hhcfrjrn 190 38 diameter diameter NN cord-298525-hhcfrjrn 190 39 . . . cord-298525-hhcfrjrn 191 1 These these DT cord-298525-hhcfrjrn 191 2 differences difference NNS cord-298525-hhcfrjrn 191 3 may may MD cord-298525-hhcfrjrn 191 4 be be VB cord-298525-hhcfrjrn 191 5 attributed attribute VBN cord-298525-hhcfrjrn 191 6 to to TO cord-298525-hhcfrjrn 191 7 study study VB cord-298525-hhcfrjrn 191 8 design design NN cord-298525-hhcfrjrn 191 9 , , , cord-298525-hhcfrjrn 191 10 as as IN cord-298525-hhcfrjrn 191 11 the the DT cord-298525-hhcfrjrn 191 12 studies study NNS cord-298525-hhcfrjrn 191 13 that that WDT cord-298525-hhcfrjrn 191 14 observed observe VBD cord-298525-hhcfrjrn 191 15 little little JJ cord-298525-hhcfrjrn 191 16 or or CC cord-298525-hhcfrjrn 191 17 no no DT cord-298525-hhcfrjrn 191 18 effect effect NN cord-298525-hhcfrjrn 191 19 on on IN cord-298525-hhcfrjrn 191 20 pupil pupil NN cord-298525-hhcfrjrn 191 21 diameter diameter NN cord-298525-hhcfrjrn 191 22 used use VBN cord-298525-hhcfrjrn 191 23 a a DT cord-298525-hhcfrjrn 191 24 defined define VBN cord-298525-hhcfrjrn 191 25 , , , cord-298525-hhcfrjrn 191 26 high high JJ cord-298525-hhcfrjrn 191 27 dose dose NN cord-298525-hhcfrjrn 191 28 ( ( -LRB- cord-298525-hhcfrjrn 191 29 27 27 CD cord-298525-hhcfrjrn 191 30 mg mg NNP cord-298525-hhcfrjrn 191 31 ∆ ∆ NNP cord-298525-hhcfrjrn 191 32 9 9 CD cord-298525-hhcfrjrn 191 33 THC THC NNP cord-298525-hhcfrjrn 191 34 ) ) -RRB- cord-298525-hhcfrjrn 191 35 and and CC cord-298525-hhcfrjrn 191 36 a a DT cord-298525-hhcfrjrn 191 37 specified specify VBN cord-298525-hhcfrjrn 191 38 time time NN cord-298525-hhcfrjrn 191 39 duration duration NN cord-298525-hhcfrjrn 191 40 between between IN cord-298525-hhcfrjrn 191 41 drug drug NN cord-298525-hhcfrjrn 191 42 administration administration NN cord-298525-hhcfrjrn 191 43 and and CC cord-298525-hhcfrjrn 191 44 pupil pupil NN cord-298525-hhcfrjrn 191 45 measurements measurement NNS cord-298525-hhcfrjrn 191 46 , , , cord-298525-hhcfrjrn 191 47 whereas whereas IN cord-298525-hhcfrjrn 191 48 Hartman Hartman NNP cord-298525-hhcfrjrn 191 49 et et NNP cord-298525-hhcfrjrn 191 50 al al NNP cord-298525-hhcfrjrn 191 51 . . NNP cord-298525-hhcfrjrn 191 52 used use VBD cord-298525-hhcfrjrn 191 53 Drug Drug NNP cord-298525-hhcfrjrn 191 54 Recognition Recognition NNP cord-298525-hhcfrjrn 191 55 Expert Expert NNP cord-298525-hhcfrjrn 191 56 examination examination NN cord-298525-hhcfrjrn 191 57 data datum NNS cord-298525-hhcfrjrn 191 58 ; ; : cord-298525-hhcfrjrn 191 59 thus thus RB cord-298525-hhcfrjrn 191 60 , , , cord-298525-hhcfrjrn 191 61 the the DT cord-298525-hhcfrjrn 191 62 exact exact JJ cord-298525-hhcfrjrn 191 63 dose dose NN cord-298525-hhcfrjrn 191 64 and and CC cord-298525-hhcfrjrn 191 65 timings timing NNS cord-298525-hhcfrjrn 191 66 are be VBP cord-298525-hhcfrjrn 191 67 undefined undefined JJ cord-298525-hhcfrjrn 191 68 [ [ -LRB- cord-298525-hhcfrjrn 191 69 113 113 CD cord-298525-hhcfrjrn 191 70 , , , cord-298525-hhcfrjrn 191 71 116 116 CD cord-298525-hhcfrjrn 191 72 , , , cord-298525-hhcfrjrn 191 73 122 122 CD cord-298525-hhcfrjrn 191 74 ] ] -RRB- cord-298525-hhcfrjrn 191 75 . . . cord-298525-hhcfrjrn 192 1 Changes change NNS cord-298525-hhcfrjrn 192 2 in in IN cord-298525-hhcfrjrn 192 3 pupil pupil NN cord-298525-hhcfrjrn 192 4 size size NN cord-298525-hhcfrjrn 192 5 and and CC cord-298525-hhcfrjrn 192 6 response response NN cord-298525-hhcfrjrn 192 7 to to IN cord-298525-hhcfrjrn 192 8 light light NN cord-298525-hhcfrjrn 192 9 have have VBP cord-298525-hhcfrjrn 192 10 been be VBN cord-298525-hhcfrjrn 192 11 reported report VBN cord-298525-hhcfrjrn 192 12 following follow VBG cord-298525-hhcfrjrn 192 13 exposure exposure NN cord-298525-hhcfrjrn 192 14 to to IN cord-298525-hhcfrjrn 192 15 toxic toxic JJ cord-298525-hhcfrjrn 192 16 chemicals chemical NNS cord-298525-hhcfrjrn 192 17 such such JJ cord-298525-hhcfrjrn 192 18 as as IN cord-298525-hhcfrjrn 192 19 organophosphates organophosphate NNS cord-298525-hhcfrjrn 192 20 , , , cord-298525-hhcfrjrn 192 21 as as RB cord-298525-hhcfrjrn 192 22 well well RB cord-298525-hhcfrjrn 192 23 as as IN cord-298525-hhcfrjrn 192 24 bacterial bacterial JJ cord-298525-hhcfrjrn 192 25 toxins toxin NNS cord-298525-hhcfrjrn 192 26 including include VBG cord-298525-hhcfrjrn 192 27 botulinum botulinum NN cord-298525-hhcfrjrn 192 28 toxin toxin NN cord-298525-hhcfrjrn 192 29 . . . cord-298525-hhcfrjrn 193 1 Ophthalmic ophthalmic JJ cord-298525-hhcfrjrn 193 2 manifestations manifestation NNS cord-298525-hhcfrjrn 193 3 are be VBP cord-298525-hhcfrjrn 193 4 early early JJ cord-298525-hhcfrjrn 193 5 and and CC cord-298525-hhcfrjrn 193 6 persistent persistent JJ cord-298525-hhcfrjrn 193 7 signs sign NNS cord-298525-hhcfrjrn 193 8 of of IN cord-298525-hhcfrjrn 193 9 botulism botulism NN cord-298525-hhcfrjrn 193 10 . . . cord-298525-hhcfrjrn 194 1 Botulinum botulinum NN cord-298525-hhcfrjrn 194 2 toxins toxin NNS cord-298525-hhcfrjrn 194 3 ( ( -LRB- cord-298525-hhcfrjrn 194 4 BTx BTx NNS cord-298525-hhcfrjrn 194 5 ) ) -RRB- cord-298525-hhcfrjrn 194 6 block block VB cord-298525-hhcfrjrn 194 7 the the DT cord-298525-hhcfrjrn 194 8 release release NN cord-298525-hhcfrjrn 194 9 of of IN cord-298525-hhcfrjrn 194 10 ACh ACh NNP cord-298525-hhcfrjrn 194 11 at at IN cord-298525-hhcfrjrn 194 12 neuromuscular neuromuscular NN cord-298525-hhcfrjrn 194 13 junctions junction NNS cord-298525-hhcfrjrn 194 14 , , , cord-298525-hhcfrjrn 194 15 post post JJ cord-298525-hhcfrjrn 194 16 - - JJ cord-298525-hhcfrjrn 194 17 ganglionic ganglionic JJ cord-298525-hhcfrjrn 194 18 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 194 19 nerve nerve NN cord-298525-hhcfrjrn 194 20 endings ending NNS cord-298525-hhcfrjrn 194 21 , , , cord-298525-hhcfrjrn 194 22 and and CC cord-298525-hhcfrjrn 194 23 post post JJ cord-298525-hhcfrjrn 194 24 - - JJ cord-298525-hhcfrjrn 194 25 ganglionic ganglionic JJ cord-298525-hhcfrjrn 194 26 sympathetic sympathetic JJ cord-298525-hhcfrjrn 194 27 nerve nerve NN cord-298525-hhcfrjrn 194 28 endings ending NNS cord-298525-hhcfrjrn 194 29 that that WDT cord-298525-hhcfrjrn 194 30 release release VBP cord-298525-hhcfrjrn 194 31 Ach Ach NNP cord-298525-hhcfrjrn 194 32 , , , cord-298525-hhcfrjrn 194 33 resulting result VBG cord-298525-hhcfrjrn 194 34 in in IN cord-298525-hhcfrjrn 194 35 paralysis paralysis NN cord-298525-hhcfrjrn 194 36 of of IN cord-298525-hhcfrjrn 194 37 the the DT cord-298525-hhcfrjrn 194 38 sympathetic sympathetic JJ cord-298525-hhcfrjrn 194 39 and and CC cord-298525-hhcfrjrn 194 40 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 194 41 innervation innervation NN cord-298525-hhcfrjrn 194 42 of of IN cord-298525-hhcfrjrn 194 43 the the DT cord-298525-hhcfrjrn 194 44 iris iris NNP cord-298525-hhcfrjrn 194 45 [ [ -LRB- cord-298525-hhcfrjrn 194 46 125 125 CD cord-298525-hhcfrjrn 194 47 , , , cord-298525-hhcfrjrn 194 48 126 126 CD cord-298525-hhcfrjrn 194 49 ] ] -RRB- cord-298525-hhcfrjrn 194 50 . . . cord-298525-hhcfrjrn 195 1 This this DT cord-298525-hhcfrjrn 195 2 may may MD cord-298525-hhcfrjrn 195 3 result result VB cord-298525-hhcfrjrn 195 4 in in IN cord-298525-hhcfrjrn 195 5 transient transient JJ cord-298525-hhcfrjrn 195 6 pupil pupil NN cord-298525-hhcfrjrn 195 7 dilation dilation NN cord-298525-hhcfrjrn 195 8 and and CC cord-298525-hhcfrjrn 195 9 attenuation attenuation NN cord-298525-hhcfrjrn 195 10 of of IN cord-298525-hhcfrjrn 195 11 the the DT cord-298525-hhcfrjrn 195 12 PLR plr NN cord-298525-hhcfrjrn 195 13 by by IN cord-298525-hhcfrjrn 195 14 uptake uptake NN cord-298525-hhcfrjrn 195 15 of of IN cord-298525-hhcfrjrn 195 16 BTx BTx NNS cord-298525-hhcfrjrn 195 17 into into IN cord-298525-hhcfrjrn 195 18 the the DT cord-298525-hhcfrjrn 195 19 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 195 20 ciliary ciliary NN cord-298525-hhcfrjrn 195 21 ganglion ganglion NN cord-298525-hhcfrjrn 195 22 or or CC cord-298525-hhcfrjrn 195 23 the the DT cord-298525-hhcfrjrn 195 24 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 195 25 neuromuscular neuromuscular JJ cord-298525-hhcfrjrn 195 26 junctions junction NNS cord-298525-hhcfrjrn 195 27 at at IN cord-298525-hhcfrjrn 195 28 the the DT cord-298525-hhcfrjrn 195 29 iris iris NNP cord-298525-hhcfrjrn 195 30 sphincter sphincter NN cord-298525-hhcfrjrn 195 31 muscle muscle NN cord-298525-hhcfrjrn 195 32 [ [ -LRB- cord-298525-hhcfrjrn 195 33 127 127 CD cord-298525-hhcfrjrn 195 34 ] ] -RRB- cord-298525-hhcfrjrn 195 35 . . . cord-298525-hhcfrjrn 196 1 There there EX cord-298525-hhcfrjrn 196 2 are be VBP cord-298525-hhcfrjrn 196 3 a a DT cord-298525-hhcfrjrn 196 4 number number NN cord-298525-hhcfrjrn 196 5 of of IN cord-298525-hhcfrjrn 196 6 reports report NNS cord-298525-hhcfrjrn 196 7 in in IN cord-298525-hhcfrjrn 196 8 the the DT cord-298525-hhcfrjrn 196 9 literature literature NN cord-298525-hhcfrjrn 196 10 describing describe VBG cord-298525-hhcfrjrn 196 11 mydriasis mydriasis NN cord-298525-hhcfrjrn 196 12 with with IN cord-298525-hhcfrjrn 196 13 an an DT cord-298525-hhcfrjrn 196 14 attenuated attenuated JJ cord-298525-hhcfrjrn 196 15 PLR plr NN cord-298525-hhcfrjrn 196 16 as as IN cord-298525-hhcfrjrn 196 17 a a DT cord-298525-hhcfrjrn 196 18 consequence consequence NN cord-298525-hhcfrjrn 196 19 of of IN cord-298525-hhcfrjrn 196 20 ingesting ingest VBG cord-298525-hhcfrjrn 196 21 contaminated contaminate VBN cord-298525-hhcfrjrn 196 22 food food NN cord-298525-hhcfrjrn 196 23 [ [ -LRB- cord-298525-hhcfrjrn 196 24 128 128 CD cord-298525-hhcfrjrn 196 25 ] ] -RRB- cord-298525-hhcfrjrn 196 26 , , , cord-298525-hhcfrjrn 196 27 or or CC cord-298525-hhcfrjrn 196 28 following follow VBG cord-298525-hhcfrjrn 196 29 injection injection NN cord-298525-hhcfrjrn 196 30 of of IN cord-298525-hhcfrjrn 196 31 BTx BTx NNS cord-298525-hhcfrjrn 196 32 [ [ -LRB- cord-298525-hhcfrjrn 196 33 129 129 CD cord-298525-hhcfrjrn 196 34 , , , cord-298525-hhcfrjrn 196 35 130 130 CD cord-298525-hhcfrjrn 196 36 ] ] -RRB- cord-298525-hhcfrjrn 196 37 . . . cord-298525-hhcfrjrn 197 1 Organophosphates Organophosphates NNP cord-298525-hhcfrjrn 197 2 , , , cord-298525-hhcfrjrn 197 3 a a DT cord-298525-hhcfrjrn 197 4 family family NN cord-298525-hhcfrjrn 197 5 of of IN cord-298525-hhcfrjrn 197 6 chemicals chemical NNS cord-298525-hhcfrjrn 197 7 that that WDT cord-298525-hhcfrjrn 197 8 includes include VBZ cord-298525-hhcfrjrn 197 9 nerve nerve NN cord-298525-hhcfrjrn 197 10 agents agent NNS cord-298525-hhcfrjrn 197 11 and and CC cord-298525-hhcfrjrn 197 12 pesticides pesticide NNS cord-298525-hhcfrjrn 197 13 , , , cord-298525-hhcfrjrn 197 14 inhibit inhibit VBP cord-298525-hhcfrjrn 197 15 cholinesterase cholinesterase NN cord-298525-hhcfrjrn 197 16 activity activity NN cord-298525-hhcfrjrn 197 17 , , , cord-298525-hhcfrjrn 197 18 resulting result VBG cord-298525-hhcfrjrn 197 19 in in IN cord-298525-hhcfrjrn 197 20 increased increase VBN cord-298525-hhcfrjrn 197 21 levels level NNS cord-298525-hhcfrjrn 197 22 of of IN cord-298525-hhcfrjrn 197 23 ACh ACh NNP cord-298525-hhcfrjrn 197 24 at at IN cord-298525-hhcfrjrn 197 25 the the DT cord-298525-hhcfrjrn 197 26 nerve nerve NN cord-298525-hhcfrjrn 197 27 synapses synapsis NNS cord-298525-hhcfrjrn 197 28 ; ; : cord-298525-hhcfrjrn 197 29 they -PRON- PRP cord-298525-hhcfrjrn 197 30 thus thus RB cord-298525-hhcfrjrn 197 31 act act VBP cord-298525-hhcfrjrn 197 32 as as IN cord-298525-hhcfrjrn 197 33 an an DT cord-298525-hhcfrjrn 197 34 indirect indirect JJ cord-298525-hhcfrjrn 197 35 cholinergic cholinergic JJ cord-298525-hhcfrjrn 197 36 agonist agonist NN cord-298525-hhcfrjrn 197 37 . . . cord-298525-hhcfrjrn 198 1 Published publish VBN cord-298525-hhcfrjrn 198 2 studies study NNS cord-298525-hhcfrjrn 198 3 by by IN cord-298525-hhcfrjrn 198 4 Dabisch Dabisch NNP cord-298525-hhcfrjrn 198 5 et et NNP cord-298525-hhcfrjrn 198 6 al al NNP cord-298525-hhcfrjrn 198 7 . . . cord-298525-hhcfrjrn 199 1 and and CC cord-298525-hhcfrjrn 199 2 others other NNS cord-298525-hhcfrjrn 199 3 suggest suggest VBP cord-298525-hhcfrjrn 199 4 that that IN cord-298525-hhcfrjrn 199 5 the the DT cord-298525-hhcfrjrn 199 6 majority majority NN cord-298525-hhcfrjrn 199 7 of of IN cord-298525-hhcfrjrn 199 8 cholinesterase cholinesterase NN cord-298525-hhcfrjrn 199 9 inhibition inhibition NN cord-298525-hhcfrjrn 199 10 observed observe VBD cord-298525-hhcfrjrn 199 11 within within IN cord-298525-hhcfrjrn 199 12 the the DT cord-298525-hhcfrjrn 199 13 eye eye NN cord-298525-hhcfrjrn 199 14 is be VBZ cord-298525-hhcfrjrn 199 15 a a DT cord-298525-hhcfrjrn 199 16 result result NN cord-298525-hhcfrjrn 199 17 of of IN cord-298525-hhcfrjrn 199 18 the the DT cord-298525-hhcfrjrn 199 19 nerve nerve NN cord-298525-hhcfrjrn 199 20 agent agent NN cord-298525-hhcfrjrn 199 21 vapour vapour NN cord-298525-hhcfrjrn 199 22 acting act VBG cord-298525-hhcfrjrn 199 23 directly directly RB cord-298525-hhcfrjrn 199 24 on on IN cord-298525-hhcfrjrn 199 25 the the DT cord-298525-hhcfrjrn 199 26 ocular ocular JJ cord-298525-hhcfrjrn 199 27 tissues tissue NNS cord-298525-hhcfrjrn 199 28 , , , cord-298525-hhcfrjrn 199 29 rather rather RB cord-298525-hhcfrjrn 199 30 than than IN cord-298525-hhcfrjrn 199 31 distributing distribute VBG cord-298525-hhcfrjrn 199 32 to to IN cord-298525-hhcfrjrn 199 33 the the DT cord-298525-hhcfrjrn 199 34 eye eye NN cord-298525-hhcfrjrn 199 35 as as IN cord-298525-hhcfrjrn 199 36 a a DT cord-298525-hhcfrjrn 199 37 result result NN cord-298525-hhcfrjrn 199 38 of of IN cord-298525-hhcfrjrn 199 39 systemic systemic JJ cord-298525-hhcfrjrn 199 40 absorption absorption NN cord-298525-hhcfrjrn 199 41 [ [ -LRB- cord-298525-hhcfrjrn 199 42 131 131 CD cord-298525-hhcfrjrn 199 43 ] ] -RRB- cord-298525-hhcfrjrn 199 44 [ [ -LRB- cord-298525-hhcfrjrn 199 45 132 132 CD cord-298525-hhcfrjrn 199 46 ] ] -RRB- cord-298525-hhcfrjrn 199 47 [ [ -LRB- cord-298525-hhcfrjrn 199 48 133 133 CD cord-298525-hhcfrjrn 199 49 ] ] -RRB- cord-298525-hhcfrjrn 199 50 . . . cord-298525-hhcfrjrn 200 1 The the DT cord-298525-hhcfrjrn 200 2 localised localised JJ cord-298525-hhcfrjrn 200 3 increase increase NN cord-298525-hhcfrjrn 200 4 in in IN cord-298525-hhcfrjrn 200 5 ACh ACh NNP cord-298525-hhcfrjrn 200 6 leads lead VBZ cord-298525-hhcfrjrn 200 7 to to IN cord-298525-hhcfrjrn 200 8 contraction contraction NN cord-298525-hhcfrjrn 200 9 of of IN cord-298525-hhcfrjrn 200 10 the the DT cord-298525-hhcfrjrn 200 11 pupillary pupillary JJ cord-298525-hhcfrjrn 200 12 sphincter sphincter NN cord-298525-hhcfrjrn 200 13 muscle muscle NN cord-298525-hhcfrjrn 200 14 , , , cord-298525-hhcfrjrn 200 15 resulting result VBG cord-298525-hhcfrjrn 200 16 in in IN cord-298525-hhcfrjrn 200 17 dose dose NN cord-298525-hhcfrjrn 200 18 - - HYPH cord-298525-hhcfrjrn 200 19 dependent dependent JJ cord-298525-hhcfrjrn 200 20 miosis miosis NN cord-298525-hhcfrjrn 200 21 [ [ -LRB- cord-298525-hhcfrjrn 200 22 132 132 CD cord-298525-hhcfrjrn 200 23 , , , cord-298525-hhcfrjrn 200 24 [ [ -LRB- cord-298525-hhcfrjrn 200 25 134 134 CD cord-298525-hhcfrjrn 200 26 ] ] -RRB- cord-298525-hhcfrjrn 200 27 [ [ -LRB- cord-298525-hhcfrjrn 200 28 135 135 CD cord-298525-hhcfrjrn 200 29 ] ] -RRB- cord-298525-hhcfrjrn 200 30 [ [ -LRB- cord-298525-hhcfrjrn 200 31 136 136 CD cord-298525-hhcfrjrn 200 32 ] ] -RRB- cord-298525-hhcfrjrn 200 33 . . . cord-298525-hhcfrjrn 201 1 Miosis Miosis NNP cord-298525-hhcfrjrn 201 2 is be VBZ cord-298525-hhcfrjrn 201 3 a a DT cord-298525-hhcfrjrn 201 4 highly highly RB cord-298525-hhcfrjrn 201 5 sensitive sensitive JJ cord-298525-hhcfrjrn 201 6 index index NN cord-298525-hhcfrjrn 201 7 of of IN cord-298525-hhcfrjrn 201 8 exposure exposure NN cord-298525-hhcfrjrn 201 9 and and CC cord-298525-hhcfrjrn 201 10 can can MD cord-298525-hhcfrjrn 201 11 occur occur VB cord-298525-hhcfrjrn 201 12 at at IN cord-298525-hhcfrjrn 201 13 exposure exposure NN cord-298525-hhcfrjrn 201 14 levels level NNS cord-298525-hhcfrjrn 201 15 below below IN cord-298525-hhcfrjrn 201 16 those those DT cord-298525-hhcfrjrn 201 17 that that WDT cord-298525-hhcfrjrn 201 18 cause cause VBP cord-298525-hhcfrjrn 201 19 systemic systemic JJ cord-298525-hhcfrjrn 201 20 effects effect NNS cord-298525-hhcfrjrn 201 21 [ [ -LRB- cord-298525-hhcfrjrn 201 22 137 137 CD cord-298525-hhcfrjrn 201 23 , , , cord-298525-hhcfrjrn 201 24 138 138 CD cord-298525-hhcfrjrn 201 25 ] ] -RRB- cord-298525-hhcfrjrn 201 26 . . . cord-298525-hhcfrjrn 202 1 In in IN cord-298525-hhcfrjrn 202 2 relevant relevant JJ cord-298525-hhcfrjrn 202 3 animal animal NN cord-298525-hhcfrjrn 202 4 models model NNS cord-298525-hhcfrjrn 202 5 , , , cord-298525-hhcfrjrn 202 6 the the DT cord-298525-hhcfrjrn 202 7 amounts amount NNS cord-298525-hhcfrjrn 202 8 of of IN cord-298525-hhcfrjrn 202 9 sarin sarin NNS cord-298525-hhcfrjrn 202 10 and and CC cord-298525-hhcfrjrn 202 11 cyclosarin cyclosarin NNP cord-298525-hhcfrjrn 202 12 required require VBD cord-298525-hhcfrjrn 202 13 to to TO cord-298525-hhcfrjrn 202 14 produce produce VB cord-298525-hhcfrjrn 202 15 miosis miosis NN cord-298525-hhcfrjrn 202 16 were be VBD cord-298525-hhcfrjrn 202 17 up up IN cord-298525-hhcfrjrn 202 18 to to IN cord-298525-hhcfrjrn 202 19 30-and 30-and CD cord-298525-hhcfrjrn 202 20 135-fold 135-fold CD cord-298525-hhcfrjrn 202 21 lower low JJR cord-298525-hhcfrjrn 202 22 , , , cord-298525-hhcfrjrn 202 23 respectively respectively RB cord-298525-hhcfrjrn 202 24 , , , cord-298525-hhcfrjrn 202 25 than than IN cord-298525-hhcfrjrn 202 26 the the DT cord-298525-hhcfrjrn 202 27 amounts amount NNS cord-298525-hhcfrjrn 202 28 required require VBN cord-298525-hhcfrjrn 202 29 for for IN cord-298525-hhcfrjrn 202 30 lethality lethality NN cord-298525-hhcfrjrn 202 31 [ [ -LRB- cord-298525-hhcfrjrn 202 32 139 139 CD cord-298525-hhcfrjrn 202 33 ] ] -RRB- cord-298525-hhcfrjrn 202 34 . . . cord-298525-hhcfrjrn 203 1 The the DT cord-298525-hhcfrjrn 203 2 PLR plr NN cord-298525-hhcfrjrn 203 3 is be VBZ cord-298525-hhcfrjrn 203 4 also also RB cord-298525-hhcfrjrn 203 5 reduced reduce VBN cord-298525-hhcfrjrn 203 6 following follow VBG cord-298525-hhcfrjrn 203 7 organophosphate organophosphate NN cord-298525-hhcfrjrn 203 8 exposure exposure NN cord-298525-hhcfrjrn 203 9 , , , cord-298525-hhcfrjrn 203 10 as as IN cord-298525-hhcfrjrn 203 11 a a DT cord-298525-hhcfrjrn 203 12 result result NN cord-298525-hhcfrjrn 203 13 of of IN cord-298525-hhcfrjrn 203 14 developing develop VBG cord-298525-hhcfrjrn 203 15 tolerance tolerance NN cord-298525-hhcfrjrn 203 16 to to IN cord-298525-hhcfrjrn 203 17 cholinergic cholinergic JJ cord-298525-hhcfrjrn 203 18 agonists agonist NNS cord-298525-hhcfrjrn 203 19 and and CC cord-298525-hhcfrjrn 203 20 desensitization desensitization NN cord-298525-hhcfrjrn 203 21 of of IN cord-298525-hhcfrjrn 203 22 muscarinic muscarinic NNP cord-298525-hhcfrjrn 203 23 ACh ACh NNP cord-298525-hhcfrjrn 203 24 receptors receptor NNS cord-298525-hhcfrjrn 203 25 within within IN cord-298525-hhcfrjrn 203 26 retinal retinal JJ cord-298525-hhcfrjrn 203 27 tissue tissue NN cord-298525-hhcfrjrn 203 28 following follow VBG cord-298525-hhcfrjrn 203 29 prolonged prolong VBN cord-298525-hhcfrjrn 203 30 exposure exposure NN cord-298525-hhcfrjrn 203 31 [ [ -LRB- cord-298525-hhcfrjrn 203 32 135 135 CD cord-298525-hhcfrjrn 203 33 , , , cord-298525-hhcfrjrn 203 34 140 140 CD cord-298525-hhcfrjrn 203 35 , , , cord-298525-hhcfrjrn 203 36 141 141 CD cord-298525-hhcfrjrn 203 37 ] ] -RRB- cord-298525-hhcfrjrn 203 38 . . . cord-298525-hhcfrjrn 204 1 The the DT cord-298525-hhcfrjrn 204 2 threshold threshold NN cord-298525-hhcfrjrn 204 3 dose dose NN cord-298525-hhcfrjrn 204 4 required require VBN cord-298525-hhcfrjrn 204 5 to to TO cord-298525-hhcfrjrn 204 6 attenuate attenuate VB cord-298525-hhcfrjrn 204 7 the the DT cord-298525-hhcfrjrn 204 8 PLR plr NN cord-298525-hhcfrjrn 204 9 is be VBZ cord-298525-hhcfrjrn 204 10 similar similar JJ cord-298525-hhcfrjrn 204 11 to to IN cord-298525-hhcfrjrn 204 12 that that DT cord-298525-hhcfrjrn 204 13 required require VBN cord-298525-hhcfrjrn 204 14 to to TO cord-298525-hhcfrjrn 204 15 produce produce VB cord-298525-hhcfrjrn 204 16 miosis miosis NN cord-298525-hhcfrjrn 204 17 , , , cord-298525-hhcfrjrn 204 18 but but CC cord-298525-hhcfrjrn 204 19 the the DT cord-298525-hhcfrjrn 204 20 duration duration NN cord-298525-hhcfrjrn 204 21 of of IN cord-298525-hhcfrjrn 204 22 the the DT cord-298525-hhcfrjrn 204 23 response response NN cord-298525-hhcfrjrn 204 24 is be VBZ cord-298525-hhcfrjrn 204 25 very very RB cord-298525-hhcfrjrn 204 26 different different JJ cord-298525-hhcfrjrn 204 27 [ [ -LRB- cord-298525-hhcfrjrn 204 28 140 140 CD cord-298525-hhcfrjrn 204 29 ] ] -RRB- cord-298525-hhcfrjrn 204 30 . . . cord-298525-hhcfrjrn 205 1 Dabisch Dabisch NNP cord-298525-hhcfrjrn 205 2 et et NNP cord-298525-hhcfrjrn 205 3 al al NNP cord-298525-hhcfrjrn 205 4 . . . cord-298525-hhcfrjrn 206 1 [ [ -LRB- cord-298525-hhcfrjrn 206 2 140 140 CD cord-298525-hhcfrjrn 206 3 ] ] -RRB- cord-298525-hhcfrjrn 206 4 observed observe VBN cord-298525-hhcfrjrn 206 5 rapid rapid JJ cord-298525-hhcfrjrn 206 6 miosis miosis NN cord-298525-hhcfrjrn 206 7 and and CC cord-298525-hhcfrjrn 206 8 attenuation attenuation NN cord-298525-hhcfrjrn 206 9 of of IN cord-298525-hhcfrjrn 206 10 the the DT cord-298525-hhcfrjrn 206 11 PLR plr NN cord-298525-hhcfrjrn 206 12 in in IN cord-298525-hhcfrjrn 206 13 a a DT cord-298525-hhcfrjrn 206 14 rodent rodent NN cord-298525-hhcfrjrn 206 15 model model NN cord-298525-hhcfrjrn 206 16 following follow VBG cord-298525-hhcfrjrn 206 17 a a DT cord-298525-hhcfrjrn 206 18 single single JJ cord-298525-hhcfrjrn 206 19 low low JJ cord-298525-hhcfrjrn 206 20 - - HYPH cord-298525-hhcfrjrn 206 21 dose dose NN cord-298525-hhcfrjrn 206 22 soman soman NN cord-298525-hhcfrjrn 206 23 vapour vapour NN cord-298525-hhcfrjrn 206 24 exposure exposure NN cord-298525-hhcfrjrn 206 25 , , , cord-298525-hhcfrjrn 206 26 but but CC cord-298525-hhcfrjrn 206 27 while while IN cord-298525-hhcfrjrn 206 28 pupil pupil NN cord-298525-hhcfrjrn 206 29 size size NN cord-298525-hhcfrjrn 206 30 returned return VBD cord-298525-hhcfrjrn 206 31 to to IN cord-298525-hhcfrjrn 206 32 normal normal JJ cord-298525-hhcfrjrn 206 33 after after IN cord-298525-hhcfrjrn 206 34 48 48 CD cord-298525-hhcfrjrn 206 35 h h NN cord-298525-hhcfrjrn 206 36 , , , cord-298525-hhcfrjrn 206 37 the the DT cord-298525-hhcfrjrn 206 38 PLR plr NN cord-298525-hhcfrjrn 206 39 took take VBD cord-298525-hhcfrjrn 206 40 up up RP cord-298525-hhcfrjrn 206 41 to to TO cord-298525-hhcfrjrn 206 42 10 10 CD cord-298525-hhcfrjrn 206 43 days day NNS cord-298525-hhcfrjrn 206 44 to to TO cord-298525-hhcfrjrn 206 45 fully fully RB cord-298525-hhcfrjrn 206 46 recover recover VB cord-298525-hhcfrjrn 206 47 . . . cord-298525-hhcfrjrn 207 1 Similarly similarly RB cord-298525-hhcfrjrn 207 2 , , , cord-298525-hhcfrjrn 207 3 exposure exposure NN cord-298525-hhcfrjrn 207 4 to to IN cord-298525-hhcfrjrn 207 5 dichlorvos dichlorvos NNP cord-298525-hhcfrjrn 207 6 vapour vapour NN cord-298525-hhcfrjrn 207 7 resulted result VBD cord-298525-hhcfrjrn 207 8 in in IN cord-298525-hhcfrjrn 207 9 a a DT cord-298525-hhcfrjrn 207 10 dose dose NN cord-298525-hhcfrjrn 207 11 - - HYPH cord-298525-hhcfrjrn 207 12 dependent dependent JJ cord-298525-hhcfrjrn 207 13 transient transient JJ cord-298525-hhcfrjrn 207 14 miotic miotic JJ cord-298525-hhcfrjrn 207 15 response response NN cord-298525-hhcfrjrn 207 16 in in IN cord-298525-hhcfrjrn 207 17 the the DT cord-298525-hhcfrjrn 207 18 guinea guinea NN cord-298525-hhcfrjrn 207 19 pig pig NN cord-298525-hhcfrjrn 207 20 ; ; : cord-298525-hhcfrjrn 207 21 however however RB cord-298525-hhcfrjrn 207 22 , , , cord-298525-hhcfrjrn 207 23 a a DT cord-298525-hhcfrjrn 207 24 persistent persistent JJ cord-298525-hhcfrjrn 207 25 enhanced enhance VBN cord-298525-hhcfrjrn 207 26 pupillary pupillary JJ cord-298525-hhcfrjrn 207 27 response response NN cord-298525-hhcfrjrn 207 28 to to IN cord-298525-hhcfrjrn 207 29 light light NN cord-298525-hhcfrjrn 207 30 was be VBD cord-298525-hhcfrjrn 207 31 observed observe VBN cord-298525-hhcfrjrn 207 32 [ [ -LRB- cord-298525-hhcfrjrn 207 33 136 136 CD cord-298525-hhcfrjrn 207 34 ] ] -RRB- cord-298525-hhcfrjrn 207 35 . . . cord-298525-hhcfrjrn 208 1 The the DT cord-298525-hhcfrjrn 208 2 recovery recovery NN cord-298525-hhcfrjrn 208 3 of of IN cord-298525-hhcfrjrn 208 4 pupil pupil NN cord-298525-hhcfrjrn 208 5 size size NN cord-298525-hhcfrjrn 208 6 is be VBZ cord-298525-hhcfrjrn 208 7 attributed attribute VBN cord-298525-hhcfrjrn 208 8 to to IN cord-298525-hhcfrjrn 208 9 desensitisation desensitisation NN cord-298525-hhcfrjrn 208 10 of of IN cord-298525-hhcfrjrn 208 11 the the DT cord-298525-hhcfrjrn 208 12 muscarinic muscarinic JJ cord-298525-hhcfrjrn 208 13 receptors receptor NNS cord-298525-hhcfrjrn 208 14 rather rather RB cord-298525-hhcfrjrn 208 15 than than IN cord-298525-hhcfrjrn 208 16 reactivation reactivation NN cord-298525-hhcfrjrn 208 17 of of IN cord-298525-hhcfrjrn 208 18 cholinesterases cholinesterase NNS cord-298525-hhcfrjrn 208 19 within within IN cord-298525-hhcfrjrn 208 20 the the DT cord-298525-hhcfrjrn 208 21 eye eye NN cord-298525-hhcfrjrn 208 22 , , , cord-298525-hhcfrjrn 208 23 which which WDT cord-298525-hhcfrjrn 208 24 may may MD cord-298525-hhcfrjrn 208 25 take take VB cord-298525-hhcfrjrn 208 26 up up IN cord-298525-hhcfrjrn 208 27 to to TO cord-298525-hhcfrjrn 208 28 6 6 CD cord-298525-hhcfrjrn 208 29 days day NNS cord-298525-hhcfrjrn 208 30 to to TO cord-298525-hhcfrjrn 208 31 recover recover VB cord-298525-hhcfrjrn 208 32 . . . cord-298525-hhcfrjrn 209 1 Consequently consequently RB cord-298525-hhcfrjrn 209 2 , , , cord-298525-hhcfrjrn 209 3 the the DT cord-298525-hhcfrjrn 209 4 PLR plr NN cord-298525-hhcfrjrn 209 5 is be VBZ cord-298525-hhcfrjrn 209 6 attenuated attenuate VBN cord-298525-hhcfrjrn 209 7 until until IN cord-298525-hhcfrjrn 209 8 muscarinic muscarinic JJ cord-298525-hhcfrjrn 209 9 receptor receptor NN cord-298525-hhcfrjrn 209 10 function function NN cord-298525-hhcfrjrn 209 11 is be VBZ cord-298525-hhcfrjrn 209 12 regained regain VBN cord-298525-hhcfrjrn 209 13 [ [ -LRB- cord-298525-hhcfrjrn 209 14 142 142 CD cord-298525-hhcfrjrn 209 15 ] ] -RRB- cord-298525-hhcfrjrn 209 16 . . . cord-298525-hhcfrjrn 210 1 In in IN cord-298525-hhcfrjrn 210 2 support support NN cord-298525-hhcfrjrn 210 3 of of IN cord-298525-hhcfrjrn 210 4 this this DT cord-298525-hhcfrjrn 210 5 , , , cord-298525-hhcfrjrn 210 6 oximes oxime NNS cord-298525-hhcfrjrn 210 7 , , , cord-298525-hhcfrjrn 210 8 which which WDT cord-298525-hhcfrjrn 210 9 reactivate reactivate VBP cord-298525-hhcfrjrn 210 10 acetylcholinesterase acetylcholinesterase NN cord-298525-hhcfrjrn 210 11 , , , cord-298525-hhcfrjrn 210 12 had have VBD cord-298525-hhcfrjrn 210 13 no no DT cord-298525-hhcfrjrn 210 14 effect effect NN cord-298525-hhcfrjrn 210 15 on on IN cord-298525-hhcfrjrn 210 16 sarin sarin NN cord-298525-hhcfrjrn 210 17 - - HYPH cord-298525-hhcfrjrn 210 18 induced induce VBN cord-298525-hhcfrjrn 210 19 miosis miosis NN cord-298525-hhcfrjrn 210 20 in in IN cord-298525-hhcfrjrn 210 21 animal animal NN cord-298525-hhcfrjrn 210 22 models model NNS cord-298525-hhcfrjrn 210 23 . . . cord-298525-hhcfrjrn 211 1 Moreover moreover RB cord-298525-hhcfrjrn 211 2 , , , cord-298525-hhcfrjrn 211 3 tropicamide tropicamide NN cord-298525-hhcfrjrn 211 4 - - : cord-298525-hhcfrjrn 211 5 a a DT cord-298525-hhcfrjrn 211 6 muscarinic muscarinic JJ cord-298525-hhcfrjrn 211 7 receptor receptor NN cord-298525-hhcfrjrn 211 8 antagonist antagonist NN cord-298525-hhcfrjrn 211 9 that that WDT cord-298525-hhcfrjrn 211 10 competes compete VBZ cord-298525-hhcfrjrn 211 11 with with IN cord-298525-hhcfrjrn 211 12 ACh ACh NNP cord-298525-hhcfrjrn 211 13 for for IN cord-298525-hhcfrjrn 211 14 binding bind VBG cord-298525-hhcfrjrn 211 15 sites site NNS cord-298525-hhcfrjrn 211 16 , , , cord-298525-hhcfrjrn 211 17 preventing prevent VBG cord-298525-hhcfrjrn 211 18 receptor receptor NN cord-298525-hhcfrjrn 211 19 desensitisation desensitisation NN cord-298525-hhcfrjrn 211 20 - - : cord-298525-hhcfrjrn 211 21 rapidly rapidly RB cord-298525-hhcfrjrn 211 22 increased increase VBN cord-298525-hhcfrjrn 211 23 pupil pupil NN cord-298525-hhcfrjrn 211 24 size size NN cord-298525-hhcfrjrn 211 25 and and CC cord-298525-hhcfrjrn 211 26 restored restore VBN cord-298525-hhcfrjrn 211 27 PLR PLR NNP cord-298525-hhcfrjrn 211 28 [ [ -LRB- cord-298525-hhcfrjrn 211 29 143 143 CD cord-298525-hhcfrjrn 211 30 ] ] -RRB- cord-298525-hhcfrjrn 211 31 . . . cord-298525-hhcfrjrn 212 1 However however RB cord-298525-hhcfrjrn 212 2 , , , cord-298525-hhcfrjrn 212 3 organophosphates organophosphate NNS cord-298525-hhcfrjrn 212 4 inactivate inactivate VBP cord-298525-hhcfrjrn 212 5 cholinesterases cholinesterase NNS cord-298525-hhcfrjrn 212 6 at at IN cord-298525-hhcfrjrn 212 7 both both CC cord-298525-hhcfrjrn 212 8 muscarinic muscarinic JJ cord-298525-hhcfrjrn 212 9 and and CC cord-298525-hhcfrjrn 212 10 nicotinic nicotinic JJ cord-298525-hhcfrjrn 212 11 receptor receptor NN cord-298525-hhcfrjrn 212 12 sites site NNS cord-298525-hhcfrjrn 212 13 and and CC cord-298525-hhcfrjrn 212 14 paradoxical paradoxical JJ cord-298525-hhcfrjrn 212 15 pupil pupil NN cord-298525-hhcfrjrn 212 16 dilation dilation NN cord-298525-hhcfrjrn 212 17 or or CC cord-298525-hhcfrjrn 212 18 mydriasis mydriasis NN cord-298525-hhcfrjrn 212 19 may may MD cord-298525-hhcfrjrn 212 20 occur occur VB cord-298525-hhcfrjrn 212 21 in in IN cord-298525-hhcfrjrn 212 22 certain certain JJ cord-298525-hhcfrjrn 212 23 circumstances circumstance NNS cord-298525-hhcfrjrn 212 24 due due JJ cord-298525-hhcfrjrn 212 25 to to IN cord-298525-hhcfrjrn 212 26 dominant dominant JJ cord-298525-hhcfrjrn 212 27 nicotinic nicotinic JJ cord-298525-hhcfrjrn 212 28 effects effect NNS cord-298525-hhcfrjrn 212 29 at at IN cord-298525-hhcfrjrn 212 30 the the DT cord-298525-hhcfrjrn 212 31 pre pre JJ cord-298525-hhcfrjrn 212 32 - - JJ cord-298525-hhcfrjrn 212 33 ganglionic ganglionic JJ cord-298525-hhcfrjrn 212 34 fibres fibre NNS cord-298525-hhcfrjrn 212 35 of of IN cord-298525-hhcfrjrn 212 36 the the DT cord-298525-hhcfrjrn 212 37 sympathetic sympathetic JJ cord-298525-hhcfrjrn 212 38 nervous nervous JJ cord-298525-hhcfrjrn 212 39 system system NN cord-298525-hhcfrjrn 212 40 , , , cord-298525-hhcfrjrn 212 41 resulting result VBG cord-298525-hhcfrjrn 212 42 in in IN cord-298525-hhcfrjrn 212 43 increased increase VBN cord-298525-hhcfrjrn 212 44 innervation innervation NN cord-298525-hhcfrjrn 212 45 of of IN cord-298525-hhcfrjrn 212 46 the the DT cord-298525-hhcfrjrn 212 47 dilator dilator NN cord-298525-hhcfrjrn 212 48 muscle muscle NN cord-298525-hhcfrjrn 212 49 [ [ -LRB- cord-298525-hhcfrjrn 212 50 144 144 CD cord-298525-hhcfrjrn 212 51 , , , cord-298525-hhcfrjrn 212 52 145 145 CD cord-298525-hhcfrjrn 212 53 ] ] -RRB- cord-298525-hhcfrjrn 212 54 . . . cord-298525-hhcfrjrn 213 1 An an DT cord-298525-hhcfrjrn 213 2 area area NN cord-298525-hhcfrjrn 213 3 of of IN cord-298525-hhcfrjrn 213 4 interest interest NN cord-298525-hhcfrjrn 213 5 that that WDT cord-298525-hhcfrjrn 213 6 currently currently RB cord-298525-hhcfrjrn 213 7 remains remain VBZ cord-298525-hhcfrjrn 213 8 unexplored unexplored JJ cord-298525-hhcfrjrn 213 9 is be VBZ cord-298525-hhcfrjrn 213 10 the the DT cord-298525-hhcfrjrn 213 11 response response NN cord-298525-hhcfrjrn 213 12 of of IN cord-298525-hhcfrjrn 213 13 the the DT cord-298525-hhcfrjrn 213 14 PLR plr NN cord-298525-hhcfrjrn 213 15 to to IN cord-298525-hhcfrjrn 213 16 infection infection NN cord-298525-hhcfrjrn 213 17 and and CC cord-298525-hhcfrjrn 213 18 the the DT cord-298525-hhcfrjrn 213 19 potential potential JJ cord-298525-hhcfrjrn 213 20 diagnostic diagnostic JJ cord-298525-hhcfrjrn 213 21 value value NN cord-298525-hhcfrjrn 213 22 of of IN cord-298525-hhcfrjrn 213 23 pupillometry pupillometry NN cord-298525-hhcfrjrn 213 24 . . . cord-298525-hhcfrjrn 214 1 The the DT cord-298525-hhcfrjrn 214 2 brain brain NN cord-298525-hhcfrjrn 214 3 monitors monitor VBZ cord-298525-hhcfrjrn 214 4 and and CC cord-298525-hhcfrjrn 214 5 modulates modulate VBZ cord-298525-hhcfrjrn 214 6 immune immune JJ cord-298525-hhcfrjrn 214 7 status status NN cord-298525-hhcfrjrn 214 8 through through IN cord-298525-hhcfrjrn 214 9 both both CC cord-298525-hhcfrjrn 214 10 humoural humoural JJ cord-298525-hhcfrjrn 214 11 and and CC cord-298525-hhcfrjrn 214 12 neural neural JJ cord-298525-hhcfrjrn 214 13 pathways pathway NNS cord-298525-hhcfrjrn 214 14 [ [ -LRB- cord-298525-hhcfrjrn 214 15 146 146 CD cord-298525-hhcfrjrn 214 16 , , , cord-298525-hhcfrjrn 214 17 147 147 CD cord-298525-hhcfrjrn 214 18 ] ] -RRB- cord-298525-hhcfrjrn 214 19 . . . cord-298525-hhcfrjrn 215 1 Neuroendocrine neuroendocrine JJ cord-298525-hhcfrjrn 215 2 responses response NNS cord-298525-hhcfrjrn 215 3 control control VBP cord-298525-hhcfrjrn 215 4 inflammation inflammation NN cord-298525-hhcfrjrn 215 5 at at IN cord-298525-hhcfrjrn 215 6 the the DT cord-298525-hhcfrjrn 215 7 systemic systemic JJ cord-298525-hhcfrjrn 215 8 level level NN cord-298525-hhcfrjrn 215 9 through through IN cord-298525-hhcfrjrn 215 10 the the DT cord-298525-hhcfrjrn 215 11 hypothalamic hypothalamic JJ cord-298525-hhcfrjrn 215 12 - - HYPH cord-298525-hhcfrjrn 215 13 pituitary pituitary NN cord-298525-hhcfrjrn 215 14 - - HYPH cord-298525-hhcfrjrn 215 15 adrenal adrenal NN cord-298525-hhcfrjrn 215 16 axis axis NN cord-298525-hhcfrjrn 215 17 [ [ -LRB- cord-298525-hhcfrjrn 215 18 148 148 CD cord-298525-hhcfrjrn 215 19 ] ] -RRB- cord-298525-hhcfrjrn 215 20 . . . cord-298525-hhcfrjrn 216 1 The the DT cord-298525-hhcfrjrn 216 2 first first JJ cord-298525-hhcfrjrn 216 3 branch branch NN cord-298525-hhcfrjrn 216 4 of of IN cord-298525-hhcfrjrn 216 5 this this DT cord-298525-hhcfrjrn 216 6 pathway pathway NN cord-298525-hhcfrjrn 216 7 , , , cord-298525-hhcfrjrn 216 8 the the DT cord-298525-hhcfrjrn 216 9 vagus vagus NN cord-298525-hhcfrjrn 216 10 nerve nerve NN cord-298525-hhcfrjrn 216 11 , , , cord-298525-hhcfrjrn 216 12 is be VBZ cord-298525-hhcfrjrn 216 13 activated activate VBN cord-298525-hhcfrjrn 216 14 either either RB cord-298525-hhcfrjrn 216 15 directly directly RB cord-298525-hhcfrjrn 216 16 by by IN cord-298525-hhcfrjrn 216 17 cytokines cytokine NNS cord-298525-hhcfrjrn 216 18 ( ( -LRB- cord-298525-hhcfrjrn 216 19 released release VBN cord-298525-hhcfrjrn 216 20 from from IN cord-298525-hhcfrjrn 216 21 innate innate JJ cord-298525-hhcfrjrn 216 22 immune immune JJ cord-298525-hhcfrjrn 216 23 cells cell NNS cord-298525-hhcfrjrn 216 24 ) ) -RRB- cord-298525-hhcfrjrn 216 25 or or CC cord-298525-hhcfrjrn 216 26 indirectly indirectly RB cord-298525-hhcfrjrn 216 27 through through IN cord-298525-hhcfrjrn 216 28 the the DT cord-298525-hhcfrjrn 216 29 chemoreceptive chemoreceptive JJ cord-298525-hhcfrjrn 216 30 cells cell NNS cord-298525-hhcfrjrn 216 31 located locate VBN cord-298525-hhcfrjrn 216 32 in in IN cord-298525-hhcfrjrn 216 33 the the DT cord-298525-hhcfrjrn 216 34 vagal vagal JJ cord-298525-hhcfrjrn 216 35 paraganglia paraganglia NNS cord-298525-hhcfrjrn 216 36 [ [ -LRB- cord-298525-hhcfrjrn 216 37 149 149 CD cord-298525-hhcfrjrn 216 38 ] ] -RRB- cord-298525-hhcfrjrn 216 39 . . . cord-298525-hhcfrjrn 217 1 The the DT cord-298525-hhcfrjrn 217 2 release release NN cord-298525-hhcfrjrn 217 3 of of IN cord-298525-hhcfrjrn 217 4 pro pro JJ cord-298525-hhcfrjrn 217 5 - - JJ cord-298525-hhcfrjrn 217 6 inflammatory inflammatory JJ cord-298525-hhcfrjrn 217 7 cytokines cytokine NNS cord-298525-hhcfrjrn 217 8 needs need VBZ cord-298525-hhcfrjrn 217 9 to to TO cord-298525-hhcfrjrn 217 10 be be VB cord-298525-hhcfrjrn 217 11 carefully carefully RB cord-298525-hhcfrjrn 217 12 controlled control VBN cord-298525-hhcfrjrn 217 13 , , , cord-298525-hhcfrjrn 217 14 as as IN cord-298525-hhcfrjrn 217 15 excessive excessive JJ cord-298525-hhcfrjrn 217 16 or or CC cord-298525-hhcfrjrn 217 17 uncontrolled uncontrolled JJ cord-298525-hhcfrjrn 217 18 release release NN cord-298525-hhcfrjrn 217 19 ( ( -LRB- cord-298525-hhcfrjrn 217 20 also also RB cord-298525-hhcfrjrn 217 21 known know VBN cord-298525-hhcfrjrn 217 22 as as IN cord-298525-hhcfrjrn 217 23 a a DT cord-298525-hhcfrjrn 217 24 " " `` cord-298525-hhcfrjrn 217 25 cytokine cytokine NN cord-298525-hhcfrjrn 217 26 storm storm NN cord-298525-hhcfrjrn 217 27 " " '' cord-298525-hhcfrjrn 217 28 ) ) -RRB- cord-298525-hhcfrjrn 218 1 may may MD cord-298525-hhcfrjrn 218 2 contribute contribute VB cord-298525-hhcfrjrn 218 3 to to IN cord-298525-hhcfrjrn 218 4 the the DT cord-298525-hhcfrjrn 218 5 pathogenesis pathogenesis NN cord-298525-hhcfrjrn 218 6 of of IN cord-298525-hhcfrjrn 218 7 infections infection NNS cord-298525-hhcfrjrn 218 8 , , , cord-298525-hhcfrjrn 218 9 including include VBG cord-298525-hhcfrjrn 218 10 the the DT cord-298525-hhcfrjrn 218 11 novel novel NN cord-298525-hhcfrjrn 218 12 coronaviruses coronaviruse NNS cord-298525-hhcfrjrn 218 13 SARS SARS NNP cord-298525-hhcfrjrn 218 14 and and CC cord-298525-hhcfrjrn 218 15 MERS MERS NNP cord-298525-hhcfrjrn 218 16 [ [ -LRB- cord-298525-hhcfrjrn 218 17 150 150 CD cord-298525-hhcfrjrn 218 18 ] ] -RRB- cord-298525-hhcfrjrn 218 19 [ [ -LRB- cord-298525-hhcfrjrn 218 20 151 151 CD cord-298525-hhcfrjrn 218 21 ] ] -RRB- cord-298525-hhcfrjrn 218 22 [ [ -LRB- cord-298525-hhcfrjrn 218 23 152 152 CD cord-298525-hhcfrjrn 218 24 ] ] -RRB- cord-298525-hhcfrjrn 218 25 , , , cord-298525-hhcfrjrn 218 26 influenza influenza NN cord-298525-hhcfrjrn 218 27 [ [ -LRB- cord-298525-hhcfrjrn 218 28 153 153 CD cord-298525-hhcfrjrn 218 29 ] ] -RRB- cord-298525-hhcfrjrn 218 30 , , , cord-298525-hhcfrjrn 218 31 and and CC cord-298525-hhcfrjrn 218 32 Ebola Ebola NNP cord-298525-hhcfrjrn 218 33 [ [ -LRB- cord-298525-hhcfrjrn 218 34 154 154 CD cord-298525-hhcfrjrn 218 35 ] ] -RRB- cord-298525-hhcfrjrn 218 36 , , , cord-298525-hhcfrjrn 218 37 as as RB cord-298525-hhcfrjrn 218 38 well well RB cord-298525-hhcfrjrn 218 39 as as IN cord-298525-hhcfrjrn 218 40 potential potential JJ cord-298525-hhcfrjrn 218 41 bacterial bacterial JJ cord-298525-hhcfrjrn 218 42 biothreat biothreat NN cord-298525-hhcfrjrn 218 43 agents agent NNS cord-298525-hhcfrjrn 218 44 such such JJ cord-298525-hhcfrjrn 218 45 as as IN cord-298525-hhcfrjrn 218 46 Burkholderia Burkholderia NNP cord-298525-hhcfrjrn 218 47 pseudomallei pseudomallei VBD cord-298525-hhcfrjrn 218 48 [ [ -LRB- cord-298525-hhcfrjrn 218 49 155 155 CD cord-298525-hhcfrjrn 218 50 ] ] -RRB- cord-298525-hhcfrjrn 218 51 and and CC cord-298525-hhcfrjrn 218 52 Yersinia Yersinia NNP cord-298525-hhcfrjrn 218 53 pestis pestis NNP cord-298525-hhcfrjrn 218 54 [ [ -LRB- cord-298525-hhcfrjrn 218 55 156 156 CD cord-298525-hhcfrjrn 218 56 ] ] -RRB- cord-298525-hhcfrjrn 218 57 . . . cord-298525-hhcfrjrn 219 1 Signals signal NNS cord-298525-hhcfrjrn 219 2 from from IN cord-298525-hhcfrjrn 219 3 the the DT cord-298525-hhcfrjrn 219 4 vagus vagus JJ cord-298525-hhcfrjrn 219 5 afferent afferent NN cord-298525-hhcfrjrn 219 6 fibres fibre NNS cord-298525-hhcfrjrn 219 7 eventually eventually RB cord-298525-hhcfrjrn 219 8 project project VBP cord-298525-hhcfrjrn 219 9 to to IN cord-298525-hhcfrjrn 219 10 the the DT cord-298525-hhcfrjrn 219 11 locus locus NN cord-298525-hhcfrjrn 219 12 coeruleus coeruleu VBZ cord-298525-hhcfrjrn 219 13 region region NN cord-298525-hhcfrjrn 219 14 of of IN cord-298525-hhcfrjrn 219 15 the the DT cord-298525-hhcfrjrn 219 16 brain brain NN cord-298525-hhcfrjrn 219 17 . . . cord-298525-hhcfrjrn 220 1 The the DT cord-298525-hhcfrjrn 220 2 locus locus NN cord-298525-hhcfrjrn 220 3 coeruleus coeruleu VBZ cord-298525-hhcfrjrn 220 4 exerts exert VBZ cord-298525-hhcfrjrn 220 5 a a DT cord-298525-hhcfrjrn 220 6 dual dual JJ cord-298525-hhcfrjrn 220 7 influence influence NN cord-298525-hhcfrjrn 220 8 on on IN cord-298525-hhcfrjrn 220 9 the the DT cord-298525-hhcfrjrn 220 10 PLR plr NN cord-298525-hhcfrjrn 220 11 , , , cord-298525-hhcfrjrn 220 12 ultimately ultimately RB cord-298525-hhcfrjrn 220 13 leading lead VBG cord-298525-hhcfrjrn 220 14 to to IN cord-298525-hhcfrjrn 220 15 pupil pupil NN cord-298525-hhcfrjrn 220 16 dilation dilation NN cord-298525-hhcfrjrn 220 17 [ [ -LRB- cord-298525-hhcfrjrn 220 18 157 157 CD cord-298525-hhcfrjrn 220 19 , , , cord-298525-hhcfrjrn 220 20 158 158 CD cord-298525-hhcfrjrn 220 21 ] ] -RRB- cord-298525-hhcfrjrn 220 22 . . . cord-298525-hhcfrjrn 221 1 Firstly firstly RB cord-298525-hhcfrjrn 221 2 , , , cord-298525-hhcfrjrn 221 3 it -PRON- PRP cord-298525-hhcfrjrn 221 4 contributes contribute VBZ cord-298525-hhcfrjrn 221 5 to to IN cord-298525-hhcfrjrn 221 6 the the DT cord-298525-hhcfrjrn 221 7 sympathetic sympathetic JJ cord-298525-hhcfrjrn 221 8 outflow outflow NN cord-298525-hhcfrjrn 221 9 that that WDT cord-298525-hhcfrjrn 221 10 innervates innervate VBZ cord-298525-hhcfrjrn 221 11 the the DT cord-298525-hhcfrjrn 221 12 pupillary pupillary JJ cord-298525-hhcfrjrn 221 13 dilator dilator NN cord-298525-hhcfrjrn 221 14 muscle muscle NN cord-298525-hhcfrjrn 221 15 . . . cord-298525-hhcfrjrn 222 1 Secondly secondly RB cord-298525-hhcfrjrn 222 2 , , , cord-298525-hhcfrjrn 222 3 it -PRON- PRP cord-298525-hhcfrjrn 222 4 attenuates attenuate VBZ cord-298525-hhcfrjrn 222 5 the the DT cord-298525-hhcfrjrn 222 6 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 222 7 outflow outflow NN cord-298525-hhcfrjrn 222 8 via via IN cord-298525-hhcfrjrn 222 9 inhibition inhibition NN cord-298525-hhcfrjrn 222 10 of of IN cord-298525-hhcfrjrn 222 11 the the DT cord-298525-hhcfrjrn 222 12 EW EW NNP cord-298525-hhcfrjrn 222 13 nucleus nucleus NN cord-298525-hhcfrjrn 222 14 . . . cord-298525-hhcfrjrn 223 1 Furthermore furthermore RB cord-298525-hhcfrjrn 223 2 , , , cord-298525-hhcfrjrn 223 3 experimental experimental JJ cord-298525-hhcfrjrn 223 4 models model NNS cord-298525-hhcfrjrn 223 5 of of IN cord-298525-hhcfrjrn 223 6 infection infection NN cord-298525-hhcfrjrn 223 7 - - HYPH cord-298525-hhcfrjrn 223 8 including include VBG cord-298525-hhcfrjrn 223 9 sepsis sepsis NN cord-298525-hhcfrjrn 223 10 [ [ -LRB- cord-298525-hhcfrjrn 223 11 159 159 CD cord-298525-hhcfrjrn 223 12 ] ] -RRB- cord-298525-hhcfrjrn 223 13 [ [ -LRB- cord-298525-hhcfrjrn 223 14 160 160 CD cord-298525-hhcfrjrn 223 15 ] ] -RRB- cord-298525-hhcfrjrn 223 16 [ [ -LRB- cord-298525-hhcfrjrn 223 17 161 161 CD cord-298525-hhcfrjrn 223 18 ] ] -RRB- cord-298525-hhcfrjrn 223 19 , , , cord-298525-hhcfrjrn 223 20 pneumococcal pneumococcal JJ cord-298525-hhcfrjrn 223 21 pneumonia pneumonia NN cord-298525-hhcfrjrn 223 22 [ [ -LRB- cord-298525-hhcfrjrn 223 23 162 162 CD cord-298525-hhcfrjrn 223 24 ] ] -RRB- cord-298525-hhcfrjrn 223 25 , , , cord-298525-hhcfrjrn 223 26 endotoxaemia endotoxaemia NN cord-298525-hhcfrjrn 223 27 [ [ -LRB- cord-298525-hhcfrjrn 223 28 163 163 CD cord-298525-hhcfrjrn 223 29 , , , cord-298525-hhcfrjrn 223 30 164 164 CD cord-298525-hhcfrjrn 223 31 ] ] -RRB- cord-298525-hhcfrjrn 223 32 , , , cord-298525-hhcfrjrn 223 33 leptospirosis leptospirosis NN cord-298525-hhcfrjrn 223 34 [ [ -LRB- cord-298525-hhcfrjrn 223 35 165 165 CD cord-298525-hhcfrjrn 223 36 , , , cord-298525-hhcfrjrn 223 37 166 166 CD cord-298525-hhcfrjrn 223 38 ] ] -RRB- cord-298525-hhcfrjrn 223 39 and and CC cord-298525-hhcfrjrn 223 40 influenza influenza VB cord-298525-hhcfrjrn 223 41 A a DT cord-298525-hhcfrjrn 223 42 [ [ -LRB- cord-298525-hhcfrjrn 223 43 167 167 CD cord-298525-hhcfrjrn 223 44 , , , cord-298525-hhcfrjrn 223 45 168 168 CD cord-298525-hhcfrjrn 223 46 ] ] -RRB- cord-298525-hhcfrjrn 223 47 -have -have : cord-298525-hhcfrjrn 223 48 also also RB cord-298525-hhcfrjrn 223 49 highlighted highlight VBD cord-298525-hhcfrjrn 223 50 the the DT cord-298525-hhcfrjrn 223 51 significance significance NN cord-298525-hhcfrjrn 223 52 of of IN cord-298525-hhcfrjrn 223 53 the the DT cord-298525-hhcfrjrn 223 54 cholinergic cholinergic JJ cord-298525-hhcfrjrn 223 55 signalling signal VBG cord-298525-hhcfrjrn 223 56 pathway pathway NN cord-298525-hhcfrjrn 223 57 during during IN cord-298525-hhcfrjrn 223 58 infection infection NN cord-298525-hhcfrjrn 223 59 . . . cord-298525-hhcfrjrn 224 1 Changes change NNS cord-298525-hhcfrjrn 224 2 to to IN cord-298525-hhcfrjrn 224 3 cholinergic cholinergic JJ cord-298525-hhcfrjrn 224 4 signalling signalling NN cord-298525-hhcfrjrn 224 5 are be VBP cord-298525-hhcfrjrn 224 6 likely likely JJ cord-298525-hhcfrjrn 224 7 to to TO cord-298525-hhcfrjrn 224 8 influence influence VB cord-298525-hhcfrjrn 224 9 the the DT cord-298525-hhcfrjrn 224 10 PLR plr NN cord-298525-hhcfrjrn 224 11 both both CC cord-298525-hhcfrjrn 224 12 directly directly RB cord-298525-hhcfrjrn 224 13 , , , cord-298525-hhcfrjrn 224 14 through through IN cord-298525-hhcfrjrn 224 15 ACh ACh NNP cord-298525-hhcfrjrn 224 16 receptors receptor NNS cord-298525-hhcfrjrn 224 17 located locate VBN cord-298525-hhcfrjrn 224 18 on on IN cord-298525-hhcfrjrn 224 19 iris iris NNP cord-298525-hhcfrjrn 224 20 sphincter sphincter NN cord-298525-hhcfrjrn 224 21 muscles muscle NNS cord-298525-hhcfrjrn 224 22 , , , cord-298525-hhcfrjrn 224 23 and and CC cord-298525-hhcfrjrn 224 24 indirectly indirectly RB cord-298525-hhcfrjrn 224 25 , , , cord-298525-hhcfrjrn 224 26 through through IN cord-298525-hhcfrjrn 224 27 altered altered JJ cord-298525-hhcfrjrn 224 28 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 224 29 nervous nervous JJ cord-298525-hhcfrjrn 224 30 system system NN cord-298525-hhcfrjrn 224 31 function function NN cord-298525-hhcfrjrn 224 32 . . . cord-298525-hhcfrjrn 225 1 Therefore therefore RB cord-298525-hhcfrjrn 225 2 , , , cord-298525-hhcfrjrn 225 3 measurement measurement NN cord-298525-hhcfrjrn 225 4 of of IN cord-298525-hhcfrjrn 225 5 the the DT cord-298525-hhcfrjrn 225 6 PLR plr NN cord-298525-hhcfrjrn 225 7 using use VBG cord-298525-hhcfrjrn 225 8 dynamic dynamic JJ cord-298525-hhcfrjrn 225 9 pupillometry pupillometry NN cord-298525-hhcfrjrn 225 10 may may MD cord-298525-hhcfrjrn 225 11 offer offer VB cord-298525-hhcfrjrn 225 12 the the DT cord-298525-hhcfrjrn 225 13 potential potential NN cord-298525-hhcfrjrn 225 14 to to TO cord-298525-hhcfrjrn 225 15 detect detect VB cord-298525-hhcfrjrn 225 16 systemic systemic JJ cord-298525-hhcfrjrn 225 17 changes change NNS cord-298525-hhcfrjrn 225 18 in in IN cord-298525-hhcfrjrn 225 19 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 225 20 and and CC cord-298525-hhcfrjrn 225 21 sympathetic sympathetic JJ cord-298525-hhcfrjrn 225 22 system system NN cord-298525-hhcfrjrn 225 23 function function NN cord-298525-hhcfrjrn 225 24 in in IN cord-298525-hhcfrjrn 225 25 response response NN cord-298525-hhcfrjrn 225 26 to to IN cord-298525-hhcfrjrn 225 27 infection infection NN cord-298525-hhcfrjrn 225 28 and and CC cord-298525-hhcfrjrn 225 29 inflammation inflammation NN cord-298525-hhcfrjrn 225 30 . . . cord-298525-hhcfrjrn 226 1 Pupillometry pupillometry NN cord-298525-hhcfrjrn 226 2 shows show VBZ cord-298525-hhcfrjrn 226 3 promise promise NN cord-298525-hhcfrjrn 226 4 as as IN cord-298525-hhcfrjrn 226 5 a a DT cord-298525-hhcfrjrn 226 6 non non JJ cord-298525-hhcfrjrn 226 7 - - JJ cord-298525-hhcfrjrn 226 8 invasive invasive JJ cord-298525-hhcfrjrn 226 9 diagnostic diagnostic JJ cord-298525-hhcfrjrn 226 10 technology technology NN cord-298525-hhcfrjrn 226 11 for for IN cord-298525-hhcfrjrn 226 12 a a DT cord-298525-hhcfrjrn 226 13 wide wide JJ cord-298525-hhcfrjrn 226 14 range range NN cord-298525-hhcfrjrn 226 15 of of IN cord-298525-hhcfrjrn 226 16 conditions condition NNS cord-298525-hhcfrjrn 226 17 . . . cord-298525-hhcfrjrn 227 1 However however RB cord-298525-hhcfrjrn 227 2 , , , cord-298525-hhcfrjrn 227 3 there there EX cord-298525-hhcfrjrn 227 4 are be VBP cord-298525-hhcfrjrn 227 5 a a DT cord-298525-hhcfrjrn 227 6 number number NN cord-298525-hhcfrjrn 227 7 of of IN cord-298525-hhcfrjrn 227 8 limitations limitation NNS cord-298525-hhcfrjrn 227 9 that that WDT cord-298525-hhcfrjrn 227 10 require require VBP cord-298525-hhcfrjrn 227 11 consideration consideration NN cord-298525-hhcfrjrn 227 12 and and CC cord-298525-hhcfrjrn 227 13 further further JJ cord-298525-hhcfrjrn 227 14 research research NN cord-298525-hhcfrjrn 227 15 is be VBZ cord-298525-hhcfrjrn 227 16 needed need VBN cord-298525-hhcfrjrn 227 17 to to TO cord-298525-hhcfrjrn 227 18 enable enable VB cord-298525-hhcfrjrn 227 19 translation translation NN cord-298525-hhcfrjrn 227 20 into into IN cord-298525-hhcfrjrn 227 21 clinical clinical JJ cord-298525-hhcfrjrn 227 22 settings setting NNS cord-298525-hhcfrjrn 227 23 . . . cord-298525-hhcfrjrn 228 1 Firstly firstly RB cord-298525-hhcfrjrn 228 2 , , , cord-298525-hhcfrjrn 228 3 PLR plr NN cord-298525-hhcfrjrn 228 4 measurements measurement NNS cord-298525-hhcfrjrn 228 5 can can MD cord-298525-hhcfrjrn 228 6 be be VB cord-298525-hhcfrjrn 228 7 influenced influence VBN cord-298525-hhcfrjrn 228 8 by by IN cord-298525-hhcfrjrn 228 9 the the DT cord-298525-hhcfrjrn 228 10 light light JJ cord-298525-hhcfrjrn 228 11 stimuli stimulus NNS cord-298525-hhcfrjrn 228 12 used use VBD cord-298525-hhcfrjrn 228 13 [ [ -LRB- cord-298525-hhcfrjrn 228 14 6 6 CD cord-298525-hhcfrjrn 228 15 , , , cord-298525-hhcfrjrn 228 16 169 169 CD cord-298525-hhcfrjrn 228 17 ] ] -RRB- cord-298525-hhcfrjrn 228 18 , , , cord-298525-hhcfrjrn 228 19 sex sex NN cord-298525-hhcfrjrn 228 20 [ [ -LRB- cord-298525-hhcfrjrn 228 21 170 170 CD cord-298525-hhcfrjrn 228 22 ] ] -RRB- cord-298525-hhcfrjrn 228 23 , , , cord-298525-hhcfrjrn 228 24 age age NN cord-298525-hhcfrjrn 228 25 [ [ -LRB- cord-298525-hhcfrjrn 228 26 171 171 CD cord-298525-hhcfrjrn 228 27 , , , cord-298525-hhcfrjrn 228 28 172 172 CD cord-298525-hhcfrjrn 228 29 ] ] -RRB- cord-298525-hhcfrjrn 228 30 and and CC cord-298525-hhcfrjrn 228 31 iris iris NNP cord-298525-hhcfrjrn 228 32 colour colour NN cord-298525-hhcfrjrn 228 33 [ [ -LRB- cord-298525-hhcfrjrn 228 34 173 173 CD cord-298525-hhcfrjrn 228 35 ] ] -RRB- cord-298525-hhcfrjrn 228 36 . . . cord-298525-hhcfrjrn 229 1 Changes change NNS cord-298525-hhcfrjrn 229 2 in in IN cord-298525-hhcfrjrn 229 3 pupil pupil NN cord-298525-hhcfrjrn 229 4 size size NN cord-298525-hhcfrjrn 229 5 are be VBP cord-298525-hhcfrjrn 229 6 also also RB cord-298525-hhcfrjrn 229 7 observed observe VBN cord-298525-hhcfrjrn 229 8 in in IN cord-298525-hhcfrjrn 229 9 response response NN cord-298525-hhcfrjrn 229 10 to to IN cord-298525-hhcfrjrn 229 11 other other JJ cord-298525-hhcfrjrn 229 12 stimuli stimulus NNS cord-298525-hhcfrjrn 229 13 , , , cord-298525-hhcfrjrn 229 14 including include VBG cord-298525-hhcfrjrn 229 15 spatial spatial JJ cord-298525-hhcfrjrn 229 16 structure structure NN cord-298525-hhcfrjrn 229 17 patterns pattern NNS cord-298525-hhcfrjrn 229 18 [ [ -LRB- cord-298525-hhcfrjrn 229 19 174 174 CD cord-298525-hhcfrjrn 229 20 , , , cord-298525-hhcfrjrn 229 21 175 175 CD cord-298525-hhcfrjrn 229 22 ] ] -RRB- cord-298525-hhcfrjrn 229 23 , , , cord-298525-hhcfrjrn 229 24 object object NN cord-298525-hhcfrjrn 229 25 nearness nearness NN cord-298525-hhcfrjrn 229 26 or or CC cord-298525-hhcfrjrn 229 27 accommodation accommodation NN cord-298525-hhcfrjrn 229 28 reflex reflex NN cord-298525-hhcfrjrn 229 29 [ [ -LRB- cord-298525-hhcfrjrn 229 30 10 10 CD cord-298525-hhcfrjrn 229 31 ] ] -RRB- cord-298525-hhcfrjrn 229 32 , , , cord-298525-hhcfrjrn 229 33 and and CC cord-298525-hhcfrjrn 229 34 a a DT cord-298525-hhcfrjrn 229 35 variety variety NN cord-298525-hhcfrjrn 229 36 of of IN cord-298525-hhcfrjrn 229 37 emotional emotional JJ cord-298525-hhcfrjrn 229 38 and and CC cord-298525-hhcfrjrn 229 39 cognitive cognitive JJ cord-298525-hhcfrjrn 229 40 stressors stressor NNS cord-298525-hhcfrjrn 229 41 [ [ -LRB- cord-298525-hhcfrjrn 229 42 176 176 CD cord-298525-hhcfrjrn 229 43 , , , cord-298525-hhcfrjrn 229 44 177 177 CD cord-298525-hhcfrjrn 229 45 ] ] -RRB- cord-298525-hhcfrjrn 229 46 . . . cord-298525-hhcfrjrn 230 1 Therefore therefore RB cord-298525-hhcfrjrn 230 2 , , , cord-298525-hhcfrjrn 230 3 it -PRON- PRP cord-298525-hhcfrjrn 230 4 is be VBZ cord-298525-hhcfrjrn 230 5 critical critical JJ cord-298525-hhcfrjrn 230 6 that that IN cord-298525-hhcfrjrn 230 7 standardised standardised JJ cord-298525-hhcfrjrn 230 8 protocols protocol NNS cord-298525-hhcfrjrn 230 9 be be VB cord-298525-hhcfrjrn 230 10 developed develop VBN cord-298525-hhcfrjrn 230 11 to to TO cord-298525-hhcfrjrn 230 12 enable enable VB cord-298525-hhcfrjrn 230 13 the the DT cord-298525-hhcfrjrn 230 14 use use NN cord-298525-hhcfrjrn 230 15 of of IN cord-298525-hhcfrjrn 230 16 pupillometry pupillometry NN cord-298525-hhcfrjrn 230 17 as as IN cord-298525-hhcfrjrn 230 18 a a DT cord-298525-hhcfrjrn 230 19 diagnostic diagnostic JJ cord-298525-hhcfrjrn 230 20 tool tool NN cord-298525-hhcfrjrn 230 21 and and CC cord-298525-hhcfrjrn 230 22 limiting limit VBG cord-298525-hhcfrjrn 230 23 factors factor NNS cord-298525-hhcfrjrn 230 24 should should MD cord-298525-hhcfrjrn 230 25 be be VB cord-298525-hhcfrjrn 230 26 considered consider VBN cord-298525-hhcfrjrn 230 27 as as IN cord-298525-hhcfrjrn 230 28 covariates covariate NNS cord-298525-hhcfrjrn 230 29 or or CC cord-298525-hhcfrjrn 230 30 exclusion exclusion NN cord-298525-hhcfrjrn 230 31 criteria criterion NNS cord-298525-hhcfrjrn 230 32 in in IN cord-298525-hhcfrjrn 230 33 PLR plr NN cord-298525-hhcfrjrn 230 34 studies study NNS cord-298525-hhcfrjrn 230 35 to to TO cord-298525-hhcfrjrn 230 36 enable enable VB cord-298525-hhcfrjrn 230 37 inter inter JJ cord-298525-hhcfrjrn 230 38 - - JJ cord-298525-hhcfrjrn 230 39 study study JJ cord-298525-hhcfrjrn 230 40 comparisons comparison NNS cord-298525-hhcfrjrn 230 41 [ [ -LRB- cord-298525-hhcfrjrn 230 42 23 23 CD cord-298525-hhcfrjrn 230 43 ] ] -RRB- cord-298525-hhcfrjrn 230 44 . . . cord-298525-hhcfrjrn 231 1 Further further JJ cord-298525-hhcfrjrn 231 2 research research NN cord-298525-hhcfrjrn 231 3 is be VBZ cord-298525-hhcfrjrn 231 4 also also RB cord-298525-hhcfrjrn 231 5 required require VBN cord-298525-hhcfrjrn 231 6 to to TO cord-298525-hhcfrjrn 231 7 establish establish VB cord-298525-hhcfrjrn 231 8 whether whether IN cord-298525-hhcfrjrn 231 9 the the DT cord-298525-hhcfrjrn 231 10 observed observed JJ cord-298525-hhcfrjrn 231 11 changes change NNS cord-298525-hhcfrjrn 231 12 in in IN cord-298525-hhcfrjrn 231 13 PLR plr NN cord-298525-hhcfrjrn 231 14 associated associate VBN cord-298525-hhcfrjrn 231 15 with with IN cord-298525-hhcfrjrn 231 16 different different JJ cord-298525-hhcfrjrn 231 17 disorders disorder NNS cord-298525-hhcfrjrn 231 18 are be VBP cord-298525-hhcfrjrn 231 19 sufficient sufficient JJ cord-298525-hhcfrjrn 231 20 in in IN cord-298525-hhcfrjrn 231 21 terms term NNS cord-298525-hhcfrjrn 231 22 of of IN cord-298525-hhcfrjrn 231 23 specificity specificity NN cord-298525-hhcfrjrn 231 24 and and CC cord-298525-hhcfrjrn 231 25 sensitivity sensitivity NN cord-298525-hhcfrjrn 231 26 to to TO cord-298525-hhcfrjrn 231 27 be be VB cord-298525-hhcfrjrn 231 28 used use VBN cord-298525-hhcfrjrn 231 29 diagnostically diagnostically RB cord-298525-hhcfrjrn 231 30 . . . cord-298525-hhcfrjrn 232 1 However however RB cord-298525-hhcfrjrn 232 2 , , , cord-298525-hhcfrjrn 232 3 the the DT cord-298525-hhcfrjrn 232 4 ease ease NN cord-298525-hhcfrjrn 232 5 of of IN cord-298525-hhcfrjrn 232 6 use use NN cord-298525-hhcfrjrn 232 7 , , , cord-298525-hhcfrjrn 232 8 non non JJ cord-298525-hhcfrjrn 232 9 - - JJ cord-298525-hhcfrjrn 232 10 invasive invasive JJ cord-298525-hhcfrjrn 232 11 nature nature NN cord-298525-hhcfrjrn 232 12 and and CC cord-298525-hhcfrjrn 232 13 low low JJ cord-298525-hhcfrjrn 232 14 cost cost NN cord-298525-hhcfrjrn 233 1 mean mean NNP cord-298525-hhcfrjrn 233 2 pupillometry pupillometry NNP cord-298525-hhcfrjrn 233 3 is be VBZ cord-298525-hhcfrjrn 233 4 well well RB cord-298525-hhcfrjrn 233 5 - - HYPH cord-298525-hhcfrjrn 233 6 placed place VBN cord-298525-hhcfrjrn 233 7 for for IN cord-298525-hhcfrjrn 233 8 inclusion inclusion NN cord-298525-hhcfrjrn 233 9 in in IN cord-298525-hhcfrjrn 233 10 early early JJ cord-298525-hhcfrjrn 233 11 diagnostic diagnostic JJ cord-298525-hhcfrjrn 233 12 screening screening NN cord-298525-hhcfrjrn 233 13 assessments assessment NNS cord-298525-hhcfrjrn 233 14 and and CC cord-298525-hhcfrjrn 233 15 could could MD cord-298525-hhcfrjrn 233 16 complement complement VB cord-298525-hhcfrjrn 233 17 other other JJ cord-298525-hhcfrjrn 233 18 sources source NNS cord-298525-hhcfrjrn 233 19 of of IN cord-298525-hhcfrjrn 233 20 information information NN cord-298525-hhcfrjrn 233 21 to to TO cord-298525-hhcfrjrn 233 22 identify identify VB cord-298525-hhcfrjrn 233 23 individuals individual NNS cord-298525-hhcfrjrn 233 24 at at IN cord-298525-hhcfrjrn 233 25 risk risk NN cord-298525-hhcfrjrn 233 26 who who WP cord-298525-hhcfrjrn 233 27 warrant warrant VBP cord-298525-hhcfrjrn 233 28 further further JJ cord-298525-hhcfrjrn 233 29 clinic clinic NN cord-298525-hhcfrjrn 233 30 investigations investigation NNS cord-298525-hhcfrjrn 233 31 . . . cord-298525-hhcfrjrn 234 1 Furthermore furthermore RB cord-298525-hhcfrjrn 234 2 , , , cord-298525-hhcfrjrn 234 3 there there EX cord-298525-hhcfrjrn 234 4 are be VBP cord-298525-hhcfrjrn 234 5 approaches approach NNS cord-298525-hhcfrjrn 234 6 that that WDT cord-298525-hhcfrjrn 234 7 have have VBP cord-298525-hhcfrjrn 234 8 been be VBN cord-298525-hhcfrjrn 234 9 exploited exploit VBN cord-298525-hhcfrjrn 234 10 in in IN cord-298525-hhcfrjrn 234 11 particular particular JJ cord-298525-hhcfrjrn 234 12 fields field NNS cord-298525-hhcfrjrn 234 13 - - , cord-298525-hhcfrjrn 234 14 such such JJ cord-298525-hhcfrjrn 234 15 as as IN cord-298525-hhcfrjrn 234 16 the the DT cord-298525-hhcfrjrn 234 17 use use NN cord-298525-hhcfrjrn 234 18 of of IN cord-298525-hhcfrjrn 234 19 chromatic chromatic JJ cord-298525-hhcfrjrn 234 20 pupillometry pupillometry NN cord-298525-hhcfrjrn 234 21 to to TO cord-298525-hhcfrjrn 234 22 measure measure VB cord-298525-hhcfrjrn 234 23 the the DT cord-298525-hhcfrjrn 234 24 response response NN cord-298525-hhcfrjrn 234 25 of of IN cord-298525-hhcfrjrn 234 26 different different JJ cord-298525-hhcfrjrn 234 27 sub sub NN cord-298525-hhcfrjrn 234 28 - - NNS cord-298525-hhcfrjrn 234 29 types type NNS cord-298525-hhcfrjrn 234 30 of of IN cord-298525-hhcfrjrn 234 31 photoreceptor photoreceptor NN cord-298525-hhcfrjrn 234 32 , , , cord-298525-hhcfrjrn 234 33 specifically specifically RB cord-298525-hhcfrjrn 234 34 ipRGCs iprgcs JJ cord-298525-hhcfrjrn 234 35 , , , cord-298525-hhcfrjrn 234 36 in in IN cord-298525-hhcfrjrn 234 37 diabetes diabetes NN cord-298525-hhcfrjrn 234 38 [ [ -LRB- cord-298525-hhcfrjrn 234 39 66 66 CD cord-298525-hhcfrjrn 234 40 ] ] -RRB- cord-298525-hhcfrjrn 234 41 and and CC cord-298525-hhcfrjrn 234 42 glaucoma glaucoma NN cord-298525-hhcfrjrn 234 43 [ [ -LRB- cord-298525-hhcfrjrn 234 44 14 14 CD cord-298525-hhcfrjrn 234 45 , , , cord-298525-hhcfrjrn 234 46 64 64 CD cord-298525-hhcfrjrn 234 47 , , , cord-298525-hhcfrjrn 234 48 65 65 CD cord-298525-hhcfrjrn 234 49 ] ] -RRB- cord-298525-hhcfrjrn 235 1 -which -which NNP cord-298525-hhcfrjrn 235 2 could could MD cord-298525-hhcfrjrn 235 3 be be VB cord-298525-hhcfrjrn 235 4 applied apply VBN cord-298525-hhcfrjrn 235 5 to to IN cord-298525-hhcfrjrn 235 6 other other JJ cord-298525-hhcfrjrn 235 7 conditions condition NNS cord-298525-hhcfrjrn 235 8 including include VBG cord-298525-hhcfrjrn 235 9 neurodegenerative neurodegenerative JJ cord-298525-hhcfrjrn 235 10 disorders disorder NNS cord-298525-hhcfrjrn 235 11 . . . cord-298525-hhcfrjrn 236 1 The the DT cord-298525-hhcfrjrn 236 2 pupillary pupillary JJ cord-298525-hhcfrjrn 236 3 light light JJ cord-298525-hhcfrjrn 236 4 reflex reflex NN cord-298525-hhcfrjrn 236 5 serves serve VBZ cord-298525-hhcfrjrn 236 6 as as IN cord-298525-hhcfrjrn 236 7 a a DT cord-298525-hhcfrjrn 236 8 valuable valuable JJ cord-298525-hhcfrjrn 236 9 indicator indicator NN cord-298525-hhcfrjrn 236 10 of of IN cord-298525-hhcfrjrn 236 11 autonomic autonomic JJ cord-298525-hhcfrjrn 236 12 nervous nervous JJ cord-298525-hhcfrjrn 236 13 system system NN cord-298525-hhcfrjrn 236 14 function function NN cord-298525-hhcfrjrn 236 15 . . . cord-298525-hhcfrjrn 237 1 Moreover moreover RB cord-298525-hhcfrjrn 237 2 , , , cord-298525-hhcfrjrn 237 3 measurement measurement NN cord-298525-hhcfrjrn 237 4 of of IN cord-298525-hhcfrjrn 237 5 the the DT cord-298525-hhcfrjrn 237 6 reflex reflex NN cord-298525-hhcfrjrn 237 7 using use VBG cord-298525-hhcfrjrn 237 8 dynamic dynamic JJ cord-298525-hhcfrjrn 237 9 pupillometry pupillometry NNP cord-298525-hhcfrjrn 237 10 provides provide VBZ cord-298525-hhcfrjrn 237 11 a a DT cord-298525-hhcfrjrn 237 12 quantitative quantitative JJ cord-298525-hhcfrjrn 237 13 , , , cord-298525-hhcfrjrn 237 14 non non JJ cord-298525-hhcfrjrn 237 15 - - JJ cord-298525-hhcfrjrn 237 16 invasive invasive JJ cord-298525-hhcfrjrn 237 17 tool tool NN cord-298525-hhcfrjrn 237 18 , , , cord-298525-hhcfrjrn 237 19 which which WDT cord-298525-hhcfrjrn 237 20 may may MD cord-298525-hhcfrjrn 237 21 aid aid VB cord-298525-hhcfrjrn 237 22 the the DT cord-298525-hhcfrjrn 237 23 diagnosis diagnosis NN cord-298525-hhcfrjrn 237 24 and and CC cord-298525-hhcfrjrn 237 25 clinical clinical JJ cord-298525-hhcfrjrn 237 26 management management NN cord-298525-hhcfrjrn 237 27 of of IN cord-298525-hhcfrjrn 237 28 a a DT cord-298525-hhcfrjrn 237 29 wide wide JJ cord-298525-hhcfrjrn 237 30 range range NN cord-298525-hhcfrjrn 237 31 of of IN cord-298525-hhcfrjrn 237 32 clinical clinical JJ cord-298525-hhcfrjrn 237 33 conditions condition NNS cord-298525-hhcfrjrn 237 34 , , , cord-298525-hhcfrjrn 237 35 varying vary VBG cord-298525-hhcfrjrn 237 36 from from IN cord-298525-hhcfrjrn 237 37 neurodegenerative neurodegenerative JJ cord-298525-hhcfrjrn 237 38 disease disease NN cord-298525-hhcfrjrn 237 39 to to IN cord-298525-hhcfrjrn 237 40 exposure exposure NN cord-298525-hhcfrjrn 237 41 to to IN cord-298525-hhcfrjrn 237 42 toxic toxic JJ cord-298525-hhcfrjrn 237 43 chemicals chemical NNS cord-298525-hhcfrjrn 237 44 . . . cord-298525-hhcfrjrn 237 45 _SP cord-298525-hhcfrjrn 238 1 Function function NN cord-298525-hhcfrjrn 238 2 of of IN cord-298525-hhcfrjrn 238 3 the the DT cord-298525-hhcfrjrn 238 4 pupil pupil NN cord-298525-hhcfrjrn 238 5 in in IN cord-298525-hhcfrjrn 238 6 vision vision NN cord-298525-hhcfrjrn 238 7 and and CC cord-298525-hhcfrjrn 238 8 information information NN cord-298525-hhcfrjrn 238 9 capacity capacity NN cord-298525-hhcfrjrn 238 10 of of IN cord-298525-hhcfrjrn 238 11 retinal retinal JJ cord-298525-hhcfrjrn 238 12 image image NN cord-298525-hhcfrjrn 238 13 Autonomic autonomic JJ cord-298525-hhcfrjrn 238 14 control control NN cord-298525-hhcfrjrn 238 15 of of IN cord-298525-hhcfrjrn 238 16 the the DT cord-298525-hhcfrjrn 238 17 eye eye NN cord-298525-hhcfrjrn 238 18 Evaluation Evaluation NNP cord-298525-hhcfrjrn 238 19 of of IN cord-298525-hhcfrjrn 238 20 the the DT cord-298525-hhcfrjrn 238 21 pupillary pupillary JJ cord-298525-hhcfrjrn 238 22 light light JJ cord-298525-hhcfrjrn 238 23 response response NN cord-298525-hhcfrjrn 238 24 as as IN cord-298525-hhcfrjrn 238 25 an an DT cord-298525-hhcfrjrn 238 26 objective objective JJ cord-298525-hhcfrjrn 238 27 measure measure NN cord-298525-hhcfrjrn 238 28 of of IN cord-298525-hhcfrjrn 238 29 visual visual JJ cord-298525-hhcfrjrn 238 30 function function NN cord-298525-hhcfrjrn 239 1 The the DT cord-298525-hhcfrjrn 239 2 Pupil Pupil NNP cord-298525-hhcfrjrn 239 3 : : : cord-298525-hhcfrjrn 239 4 Anatomy Anatomy NNP cord-298525-hhcfrjrn 239 5 , , , cord-298525-hhcfrjrn 239 6 Physiology Physiology NNP cord-298525-hhcfrjrn 239 7 , , , cord-298525-hhcfrjrn 239 8 and and CC cord-298525-hhcfrjrn 239 9 Clinical Clinical NNP cord-298525-hhcfrjrn 239 10 Applications Applications NNPS cord-298525-hhcfrjrn 239 11 Factors factor NNS cord-298525-hhcfrjrn 239 12 affecting affect VBG cord-298525-hhcfrjrn 239 13 light light NN cord-298525-hhcfrjrn 239 14 - - HYPH cord-298525-hhcfrjrn 239 15 adapted adapt VBN cord-298525-hhcfrjrn 239 16 pupil pupil NN cord-298525-hhcfrjrn 239 17 size size NN cord-298525-hhcfrjrn 239 18 in in IN cord-298525-hhcfrjrn 239 19 normal normal JJ cord-298525-hhcfrjrn 239 20 human human JJ cord-298525-hhcfrjrn 239 21 subjects subject NNS cord-298525-hhcfrjrn 239 22 Effect effect NN cord-298525-hhcfrjrn 239 23 of of IN cord-298525-hhcfrjrn 239 24 age age NN cord-298525-hhcfrjrn 239 25 and and CC cord-298525-hhcfrjrn 239 26 refractive refractive JJ cord-298525-hhcfrjrn 239 27 error error NN cord-298525-hhcfrjrn 239 28 on on IN cord-298525-hhcfrjrn 239 29 the the DT cord-298525-hhcfrjrn 239 30 melanopsin melanopsin NNP cord-298525-hhcfrjrn 239 31 mediated mediate VBN cord-298525-hhcfrjrn 239 32 post post JJ cord-298525-hhcfrjrn 239 33 - - JJ cord-298525-hhcfrjrn 239 34 illumination illumination JJ cord-298525-hhcfrjrn 239 35 pupil pupil NN cord-298525-hhcfrjrn 239 36 response response NN cord-298525-hhcfrjrn 239 37 ( ( -LRB- cord-298525-hhcfrjrn 239 38 PIPR PIPR NNP cord-298525-hhcfrjrn 239 39 ) ) -RRB- cord-298525-hhcfrjrn 240 1 The the DT cord-298525-hhcfrjrn 240 2 pupillary pupillary JJ cord-298525-hhcfrjrn 240 3 light light JJ cord-298525-hhcfrjrn 240 4 reflex reflex NN cord-298525-hhcfrjrn 240 5 in in IN cord-298525-hhcfrjrn 240 6 normal normal JJ cord-298525-hhcfrjrn 240 7 subjects subject NNS cord-298525-hhcfrjrn 241 1 The the DT cord-298525-hhcfrjrn 241 2 sleep sleep NN cord-298525-hhcfrjrn 241 3 - - HYPH cord-298525-hhcfrjrn 241 4 waking wake VBG cord-298525-hhcfrjrn 241 5 cycle cycle NN cord-298525-hhcfrjrn 241 6 and and CC cord-298525-hhcfrjrn 241 7 pupillary pupillary JJ cord-298525-hhcfrjrn 241 8 activity activity NN cord-298525-hhcfrjrn 241 9 Latency Latency NNP cord-298525-hhcfrjrn 241 10 of of IN cord-298525-hhcfrjrn 241 11 the the DT cord-298525-hhcfrjrn 241 12 pupil pupil NN cord-298525-hhcfrjrn 241 13 light light JJ cord-298525-hhcfrjrn 241 14 reflex reflex NN cord-298525-hhcfrjrn 241 15 : : : cord-298525-hhcfrjrn 241 16 Sample sample NN cord-298525-hhcfrjrn 241 17 rate rate NN cord-298525-hhcfrjrn 241 18 , , , cord-298525-hhcfrjrn 241 19 stimulus stimulus NN cord-298525-hhcfrjrn 241 20 intensity intensity NN cord-298525-hhcfrjrn 241 21 , , , cord-298525-hhcfrjrn 241 22 and and CC cord-298525-hhcfrjrn 241 23 variation variation NN cord-298525-hhcfrjrn 241 24 in in IN cord-298525-hhcfrjrn 241 25 normal normal JJ cord-298525-hhcfrjrn 241 26 subjects subject NNS cord-298525-hhcfrjrn 241 27 Learning learn VBG cord-298525-hhcfrjrn 241 28 from from IN cord-298525-hhcfrjrn 241 29 the the DT cord-298525-hhcfrjrn 241 30 pupil pupil NN cord-298525-hhcfrjrn 241 31 : : : cord-298525-hhcfrjrn 241 32 Studies study NNS cord-298525-hhcfrjrn 241 33 of of IN cord-298525-hhcfrjrn 241 34 basic basic JJ cord-298525-hhcfrjrn 241 35 mechanisms mechanism NNS cord-298525-hhcfrjrn 241 36 and and CC cord-298525-hhcfrjrn 241 37 clinical clinical JJ cord-298525-hhcfrjrn 241 38 applications application NNS cord-298525-hhcfrjrn 241 39 Intrinsically intrinsically RB cord-298525-hhcfrjrn 241 40 photosensitive photosensitive JJ cord-298525-hhcfrjrn 241 41 retinal retinal JJ cord-298525-hhcfrjrn 241 42 ganglion ganglion NN cord-298525-hhcfrjrn 241 43 cells cell NNS cord-298525-hhcfrjrn 241 44 Melanopsin Melanopsin NNP cord-298525-hhcfrjrn 241 45 - - HYPH cord-298525-hhcfrjrn 241 46 mediated mediate VBN cord-298525-hhcfrjrn 241 47 post post JJ cord-298525-hhcfrjrn 241 48 - - JJ cord-298525-hhcfrjrn 241 49 illumination illumination JJ cord-298525-hhcfrjrn 241 50 pupil pupil NN cord-298525-hhcfrjrn 241 51 response response NN cord-298525-hhcfrjrn 241 52 in in IN cord-298525-hhcfrjrn 241 53 the the DT cord-298525-hhcfrjrn 241 54 peripheral peripheral JJ cord-298525-hhcfrjrn 241 55 retina retina JJ cord-298525-hhcfrjrn 241 56 Post post JJ cord-298525-hhcfrjrn 241 57 - - JJ cord-298525-hhcfrjrn 241 58 illumination illumination JJ cord-298525-hhcfrjrn 241 59 pupil pupil NN cord-298525-hhcfrjrn 241 60 response response NN cord-298525-hhcfrjrn 241 61 in in IN cord-298525-hhcfrjrn 241 62 subjects subject NNS cord-298525-hhcfrjrn 241 63 without without IN cord-298525-hhcfrjrn 241 64 ocular ocular JJ cord-298525-hhcfrjrn 241 65 disease disease NN cord-298525-hhcfrjrn 241 66 Rhodopsin Rhodopsin NNP cord-298525-hhcfrjrn 241 67 and and CC cord-298525-hhcfrjrn 241 68 melanopsin melanopsin NN cord-298525-hhcfrjrn 241 69 contributions contribution NNS cord-298525-hhcfrjrn 241 70 to to IN cord-298525-hhcfrjrn 241 71 the the DT cord-298525-hhcfrjrn 241 72 early early JJ cord-298525-hhcfrjrn 241 73 redilation redilation NN cord-298525-hhcfrjrn 241 74 phase phase NN cord-298525-hhcfrjrn 241 75 of of IN cord-298525-hhcfrjrn 241 76 the the DT cord-298525-hhcfrjrn 241 77 post post JJ cord-298525-hhcfrjrn 241 78 - - JJ cord-298525-hhcfrjrn 241 79 illumination illumination JJ cord-298525-hhcfrjrn 241 80 pupil pupil NN cord-298525-hhcfrjrn 241 81 response response NN cord-298525-hhcfrjrn 241 82 ( ( -LRB- cord-298525-hhcfrjrn 241 83 PIPR PIPR NNP cord-298525-hhcfrjrn 241 84 ) ) -RRB- cord-298525-hhcfrjrn 241 85 Human Human NNP cord-298525-hhcfrjrn 241 86 and and CC cord-298525-hhcfrjrn 241 87 macaque macaque NN cord-298525-hhcfrjrn 241 88 pupil pupil NN cord-298525-hhcfrjrn 241 89 responses response NNS cord-298525-hhcfrjrn 241 90 driven drive VBN cord-298525-hhcfrjrn 241 91 by by IN cord-298525-hhcfrjrn 241 92 melanopsin melanopsin NN cord-298525-hhcfrjrn 241 93 - - HYPH cord-298525-hhcfrjrn 241 94 containing contain VBG cord-298525-hhcfrjrn 241 95 retinal retinal JJ cord-298525-hhcfrjrn 241 96 ganglion ganglion NN cord-298525-hhcfrjrn 241 97 cells cell NNS cord-298525-hhcfrjrn 241 98 Use Use NNP cord-298525-hhcfrjrn 241 99 of of IN cord-298525-hhcfrjrn 241 100 a a DT cord-298525-hhcfrjrn 241 101 digital digital JJ cord-298525-hhcfrjrn 241 102 infrared infrared JJ cord-298525-hhcfrjrn 241 103 pupillometer pupillometer NNP cord-298525-hhcfrjrn 241 104 to to TO cord-298525-hhcfrjrn 241 105 assess assess VB cord-298525-hhcfrjrn 241 106 patient patient JJ cord-298525-hhcfrjrn 241 107 suitability suitability NN cord-298525-hhcfrjrn 241 108 for for IN cord-298525-hhcfrjrn 241 109 refractive refractive JJ cord-298525-hhcfrjrn 241 110 surgery surgery NN cord-298525-hhcfrjrn 241 111 Repeatability repeatability NN cord-298525-hhcfrjrn 241 112 of of IN cord-298525-hhcfrjrn 241 113 the the DT cord-298525-hhcfrjrn 241 114 procyon procyon JJ cord-298525-hhcfrjrn 241 115 p3000 p3000 NNP cord-298525-hhcfrjrn 241 116 pupillometer pupillometer NNP cord-298525-hhcfrjrn 241 117 Infrared Infrared NNP cord-298525-hhcfrjrn 241 118 pupillometry pupillometry NNP cord-298525-hhcfrjrn 241 119 , , , cord-298525-hhcfrjrn 241 120 the the DT cord-298525-hhcfrjrn 241 121 Neurological Neurological NNP cord-298525-hhcfrjrn 241 122 Pupil Pupil NNP cord-298525-hhcfrjrn 241 123 index index NN cord-298525-hhcfrjrn 241 124 and and CC cord-298525-hhcfrjrn 241 125 unilateral unilateral JJ cord-298525-hhcfrjrn 241 126 pupillary pupillary JJ cord-298525-hhcfrjrn 241 127 dilation dilation NN cord-298525-hhcfrjrn 241 128 after after IN cord-298525-hhcfrjrn 241 129 traumatic traumatic JJ cord-298525-hhcfrjrn 241 130 brain brain NN cord-298525-hhcfrjrn 241 131 injury injury NN cord-298525-hhcfrjrn 241 132 : : : cord-298525-hhcfrjrn 241 133 Implications implication NNS cord-298525-hhcfrjrn 241 134 for for IN cord-298525-hhcfrjrn 241 135 treatment treatment NN cord-298525-hhcfrjrn 241 136 paradigms paradigm NNS cord-298525-hhcfrjrn 242 1 An an DT cord-298525-hhcfrjrn 242 2 open open JJ cord-298525-hhcfrjrn 242 3 - - HYPH cord-298525-hhcfrjrn 242 4 source source NN cord-298525-hhcfrjrn 242 5 , , , cord-298525-hhcfrjrn 242 6 FireWire FireWire NNP cord-298525-hhcfrjrn 242 7 camera camera NN cord-298525-hhcfrjrn 242 8 - - HYPH cord-298525-hhcfrjrn 242 9 based base VBN cord-298525-hhcfrjrn 242 10 , , , cord-298525-hhcfrjrn 242 11 Labview Labview NNP cord-298525-hhcfrjrn 242 12 - - HYPH cord-298525-hhcfrjrn 242 13 controlled control VBN cord-298525-hhcfrjrn 242 14 image image NN cord-298525-hhcfrjrn 242 15 acquisition acquisition NN cord-298525-hhcfrjrn 242 16 system system NN cord-298525-hhcfrjrn 242 17 for for IN cord-298525-hhcfrjrn 242 18 automated automate VBN cord-298525-hhcfrjrn 242 19 , , , cord-298525-hhcfrjrn 242 20 dynamic dynamic JJ cord-298525-hhcfrjrn 242 21 pupillometry pupillometry NN cord-298525-hhcfrjrn 242 22 and and CC cord-298525-hhcfrjrn 242 23 blink blink VB cord-298525-hhcfrjrn 242 24 detection detection NN cord-298525-hhcfrjrn 242 25 Pupillometric Pupillometric NNP cord-298525-hhcfrjrn 242 26 evaluation evaluation NN cord-298525-hhcfrjrn 242 27 of of IN cord-298525-hhcfrjrn 242 28 the the DT cord-298525-hhcfrjrn 242 29 dynamics dynamic NNS cord-298525-hhcfrjrn 242 30 of of IN cord-298525-hhcfrjrn 242 31 the the DT cord-298525-hhcfrjrn 242 32 pupillary pupillary JJ cord-298525-hhcfrjrn 242 33 response response NN cord-298525-hhcfrjrn 242 34 to to IN cord-298525-hhcfrjrn 242 35 a a DT cord-298525-hhcfrjrn 242 36 brief brief JJ cord-298525-hhcfrjrn 242 37 light light JJ cord-298525-hhcfrjrn 242 38 stimulus stimulus NN cord-298525-hhcfrjrn 242 39 in in IN cord-298525-hhcfrjrn 242 40 healthy healthy JJ cord-298525-hhcfrjrn 242 41 subjects subject NNS cord-298525-hhcfrjrn 243 1 The the DT cord-298525-hhcfrjrn 243 2 TimeStudio TimeStudio NNP cord-298525-hhcfrjrn 243 3 Project Project NNP cord-298525-hhcfrjrn 243 4 : : : cord-298525-hhcfrjrn 244 1 An an DT cord-298525-hhcfrjrn 244 2 open open JJ cord-298525-hhcfrjrn 244 3 source source NN cord-298525-hhcfrjrn 244 4 scientific scientific JJ cord-298525-hhcfrjrn 244 5 workflow workflow NN cord-298525-hhcfrjrn 244 6 system system NN cord-298525-hhcfrjrn 244 7 for for IN cord-298525-hhcfrjrn 244 8 the the DT cord-298525-hhcfrjrn 244 9 behavioral behavioral JJ cord-298525-hhcfrjrn 244 10 and and CC cord-298525-hhcfrjrn 244 11 brain brain NN cord-298525-hhcfrjrn 244 12 sciences sciences NNPS cord-298525-hhcfrjrn 244 13 Evaluation Evaluation NNP cord-298525-hhcfrjrn 244 14 of of IN cord-298525-hhcfrjrn 244 15 autonomic autonomic JJ cord-298525-hhcfrjrn 244 16 imbalance imbalance NN cord-298525-hhcfrjrn 244 17 in in IN cord-298525-hhcfrjrn 244 18 patients patient NNS cord-298525-hhcfrjrn 244 19 with with IN cord-298525-hhcfrjrn 244 20 heart heart NN cord-298525-hhcfrjrn 244 21 failure failure NN cord-298525-hhcfrjrn 244 22 : : : cord-298525-hhcfrjrn 244 23 A a DT cord-298525-hhcfrjrn 244 24 preliminary preliminary JJ cord-298525-hhcfrjrn 244 25 study study NN cord-298525-hhcfrjrn 244 26 of of IN cord-298525-hhcfrjrn 244 27 pupillomotor pupillomotor NN cord-298525-hhcfrjrn 244 28 function function NN cord-298525-hhcfrjrn 244 29 Parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 244 30 nervous nervous JJ cord-298525-hhcfrjrn 244 31 system system NN cord-298525-hhcfrjrn 244 32 dysfunction dysfunction NN cord-298525-hhcfrjrn 244 33 , , , cord-298525-hhcfrjrn 244 34 as as IN cord-298525-hhcfrjrn 244 35 identified identify VBN cord-298525-hhcfrjrn 244 36 by by IN cord-298525-hhcfrjrn 244 37 pupil pupil NN cord-298525-hhcfrjrn 244 38 light light JJ cord-298525-hhcfrjrn 244 39 reflex reflex NN cord-298525-hhcfrjrn 244 40 , , , cord-298525-hhcfrjrn 244 41 and and CC cord-298525-hhcfrjrn 244 42 its -PRON- PRP$ cord-298525-hhcfrjrn 244 43 possible possible JJ cord-298525-hhcfrjrn 244 44 connection connection NN cord-298525-hhcfrjrn 244 45 to to IN cord-298525-hhcfrjrn 244 46 hearing hear VBG cord-298525-hhcfrjrn 244 47 impairment impairment NN cord-298525-hhcfrjrn 245 1 The the DT cord-298525-hhcfrjrn 245 2 Determination determination NN cord-298525-hhcfrjrn 245 3 of of IN cord-298525-hhcfrjrn 245 4 Rod Rod NNP cord-298525-hhcfrjrn 245 5 and and CC cord-298525-hhcfrjrn 245 6 Cone Cone NNP cord-298525-hhcfrjrn 245 7 Photoreceptor Photoreceptor NNP cord-298525-hhcfrjrn 245 8 Fate Fate NNP cord-298525-hhcfrjrn 246 1 Why why WRB cord-298525-hhcfrjrn 246 2 rods rod NNS cord-298525-hhcfrjrn 246 3 and and CC cord-298525-hhcfrjrn 246 4 cones cone NNS cord-298525-hhcfrjrn 246 5 ? ? . cord-298525-hhcfrjrn 247 1 Eye eye NN cord-298525-hhcfrjrn 247 2 Explaining explain VBG cord-298525-hhcfrjrn 247 3 the the DT cord-298525-hhcfrjrn 247 4 functional functional JJ cord-298525-hhcfrjrn 247 5 differences difference NNS cord-298525-hhcfrjrn 247 6 of of IN cord-298525-hhcfrjrn 247 7 rods rod NNS cord-298525-hhcfrjrn 247 8 versus versus IN cord-298525-hhcfrjrn 247 9 cones cone NNS cord-298525-hhcfrjrn 247 10 Inhibitory Inhibitory NNP cord-298525-hhcfrjrn 247 11 Interneurons Interneurons NNPS cord-298525-hhcfrjrn 247 12 in in IN cord-298525-hhcfrjrn 247 13 the the DT cord-298525-hhcfrjrn 247 14 Retina retina NN cord-298525-hhcfrjrn 247 15 : : : cord-298525-hhcfrjrn 247 16 Types type NNS cord-298525-hhcfrjrn 247 17 , , , cord-298525-hhcfrjrn 247 18 Circuitry Circuitry NNP cord-298525-hhcfrjrn 247 19 , , , cord-298525-hhcfrjrn 247 20 and and CC cord-298525-hhcfrjrn 247 21 Function Function NNP cord-298525-hhcfrjrn 247 22 Melanopsin Melanopsin NNP cord-298525-hhcfrjrn 247 23 - - HYPH cord-298525-hhcfrjrn 247 24 expressing express VBG cord-298525-hhcfrjrn 247 25 ganglion ganglion NN cord-298525-hhcfrjrn 247 26 cells cell NNS cord-298525-hhcfrjrn 247 27 in in IN cord-298525-hhcfrjrn 247 28 primate primate JJ cord-298525-hhcfrjrn 247 29 retina retina NN cord-298525-hhcfrjrn 247 30 signal signal NN cord-298525-hhcfrjrn 247 31 colour colour NN cord-298525-hhcfrjrn 247 32 and and CC cord-298525-hhcfrjrn 247 33 irradiance irradiance NN cord-298525-hhcfrjrn 247 34 and and CC cord-298525-hhcfrjrn 247 35 project project NN cord-298525-hhcfrjrn 247 36 to to IN cord-298525-hhcfrjrn 247 37 the the DT cord-298525-hhcfrjrn 247 38 LGN LGN NNP cord-298525-hhcfrjrn 247 39 Melanopsin Melanopsin NNP cord-298525-hhcfrjrn 247 40 - - HYPH cord-298525-hhcfrjrn 247 41 expressing express VBG cord-298525-hhcfrjrn 247 42 ganglion ganglion NN cord-298525-hhcfrjrn 247 43 cells cell NNS cord-298525-hhcfrjrn 247 44 on on IN cord-298525-hhcfrjrn 247 45 macaque macaque NN cord-298525-hhcfrjrn 247 46 and and CC cord-298525-hhcfrjrn 247 47 human human JJ cord-298525-hhcfrjrn 247 48 retinas retina NNS cord-298525-hhcfrjrn 247 49 form form VBP cord-298525-hhcfrjrn 247 50 two two CD cord-298525-hhcfrjrn 247 51 morphologically morphologically RB cord-298525-hhcfrjrn 247 52 distinct distinct JJ cord-298525-hhcfrjrn 247 53 populations population NNS cord-298525-hhcfrjrn 247 54 Melanopsin Melanopsin NNP cord-298525-hhcfrjrn 247 55 - - HYPH cord-298525-hhcfrjrn 247 56 expressing express VBG cord-298525-hhcfrjrn 247 57 ganglion ganglion NN cord-298525-hhcfrjrn 247 58 cells cell NNS cord-298525-hhcfrjrn 247 59 in in IN cord-298525-hhcfrjrn 247 60 human human JJ cord-298525-hhcfrjrn 247 61 retina retina NN cord-298525-hhcfrjrn 247 62 : : : cord-298525-hhcfrjrn 247 63 Morphology morphology NN cord-298525-hhcfrjrn 247 64 , , , cord-298525-hhcfrjrn 247 65 distribution distribution NN cord-298525-hhcfrjrn 247 66 , , , cord-298525-hhcfrjrn 247 67 and and CC cord-298525-hhcfrjrn 247 68 synaptic synaptic JJ cord-298525-hhcfrjrn 247 69 connections connection NNS cord-298525-hhcfrjrn 247 70 Phototransduction Phototransduction NNP cord-298525-hhcfrjrn 247 71 by by IN cord-298525-hhcfrjrn 247 72 retinal retinal JJ cord-298525-hhcfrjrn 247 73 ganglion ganglion NN cord-298525-hhcfrjrn 247 74 cells cell NNS cord-298525-hhcfrjrn 247 75 that that WDT cord-298525-hhcfrjrn 247 76 set set VBD cord-298525-hhcfrjrn 247 77 the the DT cord-298525-hhcfrjrn 247 78 circadian circadian NN cord-298525-hhcfrjrn 247 79 clock clock NN cord-298525-hhcfrjrn 247 80 Melanopsin Melanopsin NNP cord-298525-hhcfrjrn 247 81 regulates regulate VBZ cord-298525-hhcfrjrn 247 82 visual visual JJ cord-298525-hhcfrjrn 247 83 processing processing NN cord-298525-hhcfrjrn 247 84 in in IN cord-298525-hhcfrjrn 247 85 the the DT cord-298525-hhcfrjrn 247 86 mouse mouse NN cord-298525-hhcfrjrn 247 87 retina retina NN cord-298525-hhcfrjrn 247 88 Melanopsin Melanopsin NNP cord-298525-hhcfrjrn 247 89 - - HYPH cord-298525-hhcfrjrn 247 90 containing contain VBG cord-298525-hhcfrjrn 247 91 retinal retinal JJ cord-298525-hhcfrjrn 247 92 ganglion ganglion NN cord-298525-hhcfrjrn 247 93 cells cell NNS cord-298525-hhcfrjrn 247 94 : : : cord-298525-hhcfrjrn 248 1 Architecture architecture NN cord-298525-hhcfrjrn 248 2 , , , cord-298525-hhcfrjrn 248 3 projections projection NNS cord-298525-hhcfrjrn 248 4 , , , cord-298525-hhcfrjrn 248 5 and and CC cord-298525-hhcfrjrn 248 6 intrinsic intrinsic JJ cord-298525-hhcfrjrn 248 7 photosensitivity photosensitivity NN cord-298525-hhcfrjrn 248 8 Cholinergic cholinergic JJ cord-298525-hhcfrjrn 248 9 deficiency deficiency NN cord-298525-hhcfrjrn 248 10 in in IN cord-298525-hhcfrjrn 248 11 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 248 12 's 's POS cord-298525-hhcfrjrn 248 13 and and CC cord-298525-hhcfrjrn 248 14 Parkinson Parkinson NNP cord-298525-hhcfrjrn 248 15 's 's POS cord-298525-hhcfrjrn 248 16 disease disease NN cord-298525-hhcfrjrn 248 17 : : : cord-298525-hhcfrjrn 248 18 Evaluation evaluation NN cord-298525-hhcfrjrn 248 19 with with IN cord-298525-hhcfrjrn 248 20 pupillometry pupillometry NNP cord-298525-hhcfrjrn 248 21 Pupil Pupil NNP cord-298525-hhcfrjrn 248 22 light light JJ cord-298525-hhcfrjrn 248 23 reflex reflex NN cord-298525-hhcfrjrn 248 24 in in IN cord-298525-hhcfrjrn 248 25 Parkinson Parkinson NNP cord-298525-hhcfrjrn 248 26 's 's POS cord-298525-hhcfrjrn 248 27 disease disease NN cord-298525-hhcfrjrn 248 28 : : : cord-298525-hhcfrjrn 248 29 Evaluation evaluation NN cord-298525-hhcfrjrn 248 30 with with IN cord-298525-hhcfrjrn 248 31 pupillometry pupillometry NN cord-298525-hhcfrjrn 248 32 Disordered disordered JJ cord-298525-hhcfrjrn 248 33 pupil pupil NN cord-298525-hhcfrjrn 248 34 reactivity reactivity NN cord-298525-hhcfrjrn 248 35 in in IN cord-298525-hhcfrjrn 248 36 Parkinson Parkinson NNP cord-298525-hhcfrjrn 248 37 's 's POS cord-298525-hhcfrjrn 248 38 disease disease NN cord-298525-hhcfrjrn 248 39 Pupillometric Pupillometric NNP cord-298525-hhcfrjrn 248 40 findings finding NNS cord-298525-hhcfrjrn 248 41 in in IN cord-298525-hhcfrjrn 248 42 patients patient NNS cord-298525-hhcfrjrn 248 43 with with IN cord-298525-hhcfrjrn 248 44 Parkinson Parkinson NNP cord-298525-hhcfrjrn 248 45 's 's POS cord-298525-hhcfrjrn 248 46 disease disease NN cord-298525-hhcfrjrn 248 47 and and CC cord-298525-hhcfrjrn 248 48 cognitive cognitive JJ cord-298525-hhcfrjrn 248 49 disorder disorder NN cord-298525-hhcfrjrn 249 1 Abnormal abnormal JJ cord-298525-hhcfrjrn 249 2 transient transient JJ cord-298525-hhcfrjrn 249 3 pupillary pupillary JJ cord-298525-hhcfrjrn 249 4 light light JJ cord-298525-hhcfrjrn 249 5 reflex reflex NN cord-298525-hhcfrjrn 249 6 in in IN cord-298525-hhcfrjrn 249 7 individuals individual NNS cord-298525-hhcfrjrn 249 8 with with IN cord-298525-hhcfrjrn 249 9 autism autism NN cord-298525-hhcfrjrn 249 10 spectrum spectrum NN cord-298525-hhcfrjrn 249 11 disorders disorder NNS cord-298525-hhcfrjrn 249 12 Patterns pattern NNS cord-298525-hhcfrjrn 249 13 of of IN cord-298525-hhcfrjrn 249 14 pupillary pupillary JJ cord-298525-hhcfrjrn 249 15 dilatation dilatation NN cord-298525-hhcfrjrn 249 16 and and CC cord-298525-hhcfrjrn 249 17 constriction constriction NN cord-298525-hhcfrjrn 249 18 in in IN cord-298525-hhcfrjrn 249 19 psychotic psychotic JJ cord-298525-hhcfrjrn 249 20 adults adult NNS cord-298525-hhcfrjrn 249 21 and and CC cord-298525-hhcfrjrn 249 22 autistic autistic JJ cord-298525-hhcfrjrn 249 23 children child NNS cord-298525-hhcfrjrn 250 1 The the DT cord-298525-hhcfrjrn 250 2 post post JJ cord-298525-hhcfrjrn 250 3 - - JJ cord-298525-hhcfrjrn 250 4 illumination illumination JJ cord-298525-hhcfrjrn 250 5 pupil pupil NN cord-298525-hhcfrjrn 250 6 response response NN cord-298525-hhcfrjrn 250 7 is be VBZ cord-298525-hhcfrjrn 250 8 reduced reduce VBN cord-298525-hhcfrjrn 250 9 in in IN cord-298525-hhcfrjrn 250 10 glaucoma glaucoma NN cord-298525-hhcfrjrn 250 11 patients patient NNS cord-298525-hhcfrjrn 250 12 Intrinsically intrinsically RB cord-298525-hhcfrjrn 250 13 photosensitive photosensitive JJ cord-298525-hhcfrjrn 250 14 ( ( -LRB- cord-298525-hhcfrjrn 250 15 melanopsin melanopsin NNP cord-298525-hhcfrjrn 250 16 ) ) -RRB- cord-298525-hhcfrjrn 250 17 retinal retinal JJ cord-298525-hhcfrjrn 250 18 ganglion ganglion NN cord-298525-hhcfrjrn 250 19 cell cell NN cord-298525-hhcfrjrn 250 20 function function NN cord-298525-hhcfrjrn 250 21 in in IN cord-298525-hhcfrjrn 250 22 glaucoma glaucoma NN cord-298525-hhcfrjrn 250 23 Monochromatic monochromatic JJ cord-298525-hhcfrjrn 250 24 pupillometry pupillometry NN cord-298525-hhcfrjrn 250 25 in in IN cord-298525-hhcfrjrn 250 26 unilateral unilateral JJ cord-298525-hhcfrjrn 250 27 glaucoma glaucoma NN cord-298525-hhcfrjrn 250 28 discloses disclose VBZ cord-298525-hhcfrjrn 250 29 no no DT cord-298525-hhcfrjrn 250 30 adaptive adaptive JJ cord-298525-hhcfrjrn 250 31 changes change NNS cord-298525-hhcfrjrn 250 32 subserved subserve VBN cord-298525-hhcfrjrn 250 33 by by IN cord-298525-hhcfrjrn 250 34 the the DT cord-298525-hhcfrjrn 250 35 ipRGCs iprgcs JJ cord-298525-hhcfrjrn 251 1 The the DT cord-298525-hhcfrjrn 251 2 post post JJ cord-298525-hhcfrjrn 251 3 - - JJ cord-298525-hhcfrjrn 251 4 illumination illumination JJ cord-298525-hhcfrjrn 251 5 pupil pupil NN cord-298525-hhcfrjrn 251 6 response response NN cord-298525-hhcfrjrn 251 7 of of IN cord-298525-hhcfrjrn 251 8 melanopsin melanopsin NN cord-298525-hhcfrjrn 251 9 - - HYPH cord-298525-hhcfrjrn 251 10 expressing express VBG cord-298525-hhcfrjrn 251 11 intrinsically intrinsically RB cord-298525-hhcfrjrn 251 12 photosensitive photosensitive JJ cord-298525-hhcfrjrn 251 13 retinal retinal JJ cord-298525-hhcfrjrn 251 14 ganglion ganglion NN cord-298525-hhcfrjrn 251 15 cells cell NNS cord-298525-hhcfrjrn 251 16 in in IN cord-298525-hhcfrjrn 251 17 diabetes diabetes NN cord-298525-hhcfrjrn 251 18 Pupillography Pupillography NNP cord-298525-hhcfrjrn 251 19 refines refine VBZ cord-298525-hhcfrjrn 251 20 the the DT cord-298525-hhcfrjrn 251 21 diagnosis diagnosis NN cord-298525-hhcfrjrn 251 22 of of IN cord-298525-hhcfrjrn 251 23 diabetic diabetic JJ cord-298525-hhcfrjrn 251 24 autonomic autonomic JJ cord-298525-hhcfrjrn 251 25 neuropathy neuropathy NN cord-298525-hhcfrjrn 251 26 Using use VBG cord-298525-hhcfrjrn 251 27 dynamic dynamic JJ cord-298525-hhcfrjrn 251 28 pupillometry pupillometry NN cord-298525-hhcfrjrn 251 29 as as IN cord-298525-hhcfrjrn 251 30 a a DT cord-298525-hhcfrjrn 251 31 simple simple JJ cord-298525-hhcfrjrn 251 32 screening screening NN cord-298525-hhcfrjrn 251 33 tool tool NN cord-298525-hhcfrjrn 251 34 to to TO cord-298525-hhcfrjrn 251 35 detect detect VB cord-298525-hhcfrjrn 251 36 autonomic autonomic JJ cord-298525-hhcfrjrn 251 37 neuropathy neuropathy NN cord-298525-hhcfrjrn 251 38 in in IN cord-298525-hhcfrjrn 251 39 patients patient NNS cord-298525-hhcfrjrn 251 40 with with IN cord-298525-hhcfrjrn 251 41 diabetes diabetes NN cord-298525-hhcfrjrn 251 42 : : : cord-298525-hhcfrjrn 252 1 A a DT cord-298525-hhcfrjrn 252 2 pilot pilot NN cord-298525-hhcfrjrn 252 3 study study NN cord-298525-hhcfrjrn 253 1 The the DT cord-298525-hhcfrjrn 253 2 pupillary pupillary JJ cord-298525-hhcfrjrn 253 3 light light JJ cord-298525-hhcfrjrn 253 4 reflex reflex NN cord-298525-hhcfrjrn 253 5 in in IN cord-298525-hhcfrjrn 253 6 borderline borderline JJ cord-298525-hhcfrjrn 253 7 diabetics diabetic NNS cord-298525-hhcfrjrn 253 8 Disproportionate disproportionate JJ cord-298525-hhcfrjrn 253 9 pupillary pupillary JJ cord-298525-hhcfrjrn 253 10 involvement involvement NN cord-298525-hhcfrjrn 253 11 in in IN cord-298525-hhcfrjrn 253 12 diabetic diabetic JJ cord-298525-hhcfrjrn 253 13 autonomic autonomic JJ cord-298525-hhcfrjrn 253 14 neuropathy neuropathy NN cord-298525-hhcfrjrn 253 15 Early Early NNP cord-298525-hhcfrjrn 253 16 Absent Absent NNP cord-298525-hhcfrjrn 253 17 Pupillary Pupillary NNP cord-298525-hhcfrjrn 253 18 Light Light NNP cord-298525-hhcfrjrn 253 19 Reflexes Reflexes NNPS cord-298525-hhcfrjrn 254 1 After after IN cord-298525-hhcfrjrn 254 2 Cardiac Cardiac NNP cord-298525-hhcfrjrn 254 3 Arrest Arrest NNP cord-298525-hhcfrjrn 254 4 in in IN cord-298525-hhcfrjrn 254 5 Patients patient NNS cord-298525-hhcfrjrn 254 6 Treated treat VBN cord-298525-hhcfrjrn 254 7 with with IN cord-298525-hhcfrjrn 254 8 Therapeutic therapeutic JJ cord-298525-hhcfrjrn 254 9 Hypothermia Hypothermia NNP cord-298525-hhcfrjrn 254 10 Pupil Pupil NNP cord-298525-hhcfrjrn 254 11 reaction reaction NN cord-298525-hhcfrjrn 254 12 to to IN cord-298525-hhcfrjrn 254 13 light light NN cord-298525-hhcfrjrn 254 14 in in IN cord-298525-hhcfrjrn 254 15 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 254 16 's 's POS cord-298525-hhcfrjrn 254 17 disease disease NN cord-298525-hhcfrjrn 254 18 : : : cord-298525-hhcfrjrn 254 19 Evaluation evaluation NN cord-298525-hhcfrjrn 254 20 of of IN cord-298525-hhcfrjrn 254 21 pupil pupil NN cord-298525-hhcfrjrn 254 22 size size NN cord-298525-hhcfrjrn 254 23 changes change NNS cord-298525-hhcfrjrn 254 24 and and CC cord-298525-hhcfrjrn 254 25 mobility mobility NN cord-298525-hhcfrjrn 254 26 Tropicamide Tropicamide NNP cord-298525-hhcfrjrn 254 27 effects effect NNS cord-298525-hhcfrjrn 254 28 on on IN cord-298525-hhcfrjrn 254 29 pupil pupil NN cord-298525-hhcfrjrn 254 30 size size NN cord-298525-hhcfrjrn 254 31 and and CC cord-298525-hhcfrjrn 254 32 pupillary pupillary JJ cord-298525-hhcfrjrn 254 33 light light JJ cord-298525-hhcfrjrn 254 34 reflexes reflex NNS cord-298525-hhcfrjrn 254 35 in in IN cord-298525-hhcfrjrn 254 36 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 254 37 's 's POS cord-298525-hhcfrjrn 254 38 and and CC cord-298525-hhcfrjrn 255 1 Parkinson Parkinson NNP cord-298525-hhcfrjrn 255 2 's 's POS cord-298525-hhcfrjrn 255 3 disease disease NN cord-298525-hhcfrjrn 255 4 Altered alter VBD cord-298525-hhcfrjrn 255 5 pupillary pupillary JJ cord-298525-hhcfrjrn 255 6 size size NN cord-298525-hhcfrjrn 255 7 and and CC cord-298525-hhcfrjrn 255 8 darkness darkness NN cord-298525-hhcfrjrn 255 9 and and CC cord-298525-hhcfrjrn 255 10 light light JJ cord-298525-hhcfrjrn 255 11 reflexes reflex NNS cord-298525-hhcfrjrn 255 12 in in IN cord-298525-hhcfrjrn 255 13 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 255 14 's 's POS cord-298525-hhcfrjrn 255 15 disease disease NN cord-298525-hhcfrjrn 255 16 Pupillometry Pupillometry NNP cord-298525-hhcfrjrn 255 17 and and CC cord-298525-hhcfrjrn 256 1 123I 123i LS cord-298525-hhcfrjrn 256 2 - - HYPH cord-298525-hhcfrjrn 256 3 DaTSCAN DaTSCAN NNP cord-298525-hhcfrjrn 256 4 imaging imaging NN cord-298525-hhcfrjrn 256 5 in in IN cord-298525-hhcfrjrn 256 6 Parkinson Parkinson NNP cord-298525-hhcfrjrn 256 7 's 's POS cord-298525-hhcfrjrn 256 8 disease disease NN cord-298525-hhcfrjrn 256 9 : : : cord-298525-hhcfrjrn 256 10 A a DT cord-298525-hhcfrjrn 256 11 comparison comparison NN cord-298525-hhcfrjrn 256 12 study study NN cord-298525-hhcfrjrn 256 13 Is be VBZ cord-298525-hhcfrjrn 256 14 videopupillography videopupillography NN cord-298525-hhcfrjrn 256 15 useful useful JJ cord-298525-hhcfrjrn 256 16 in in IN cord-298525-hhcfrjrn 256 17 the the DT cord-298525-hhcfrjrn 256 18 diagnosis diagnosis NN cord-298525-hhcfrjrn 256 19 of of IN cord-298525-hhcfrjrn 256 20 Alzheimer Alzheimer NNP cord-298525-hhcfrjrn 256 21 's 's POS cord-298525-hhcfrjrn 256 22 disease disease NN cord-298525-hhcfrjrn 256 23 ? ? . cord-298525-hhcfrjrn 257 1 Neurology Neurology NNP cord-298525-hhcfrjrn 257 2 Effect Effect NNP cord-298525-hhcfrjrn 257 3 of of IN cord-298525-hhcfrjrn 257 4 stimulus stimulus NN cord-298525-hhcfrjrn 257 5 size size NN cord-298525-hhcfrjrn 257 6 and and CC cord-298525-hhcfrjrn 257 7 luminance luminance NN cord-298525-hhcfrjrn 257 8 on on IN cord-298525-hhcfrjrn 257 9 the the DT cord-298525-hhcfrjrn 257 10 rod- rod- NN cord-298525-hhcfrjrn 257 11 , , , cord-298525-hhcfrjrn 257 12 cone- cone- JJ cord-298525-hhcfrjrn 257 13 , , , cord-298525-hhcfrjrn 257 14 and and CC cord-298525-hhcfrjrn 257 15 melanopsin melanopsin NN cord-298525-hhcfrjrn 257 16 - - HYPH cord-298525-hhcfrjrn 257 17 mediated mediate VBN cord-298525-hhcfrjrn 257 18 pupillary pupillary JJ cord-298525-hhcfrjrn 257 19 light light JJ cord-298525-hhcfrjrn 257 20 reflex reflex NN cord-298525-hhcfrjrn 258 1 A a DT cord-298525-hhcfrjrn 258 2 method method NN cord-298525-hhcfrjrn 258 3 for for IN cord-298525-hhcfrjrn 258 4 monitoring monitor VBG cord-298525-hhcfrjrn 258 5 autonomic autonomic JJ cord-298525-hhcfrjrn 258 6 nervous nervous JJ cord-298525-hhcfrjrn 258 7 activity activity NN cord-298525-hhcfrjrn 258 8 by by IN cord-298525-hhcfrjrn 258 9 pupillary pupillary JJ cord-298525-hhcfrjrn 258 10 flash flash NN cord-298525-hhcfrjrn 258 11 response response NN cord-298525-hhcfrjrn 258 12 The the DT cord-298525-hhcfrjrn 258 13 localizing localize VBG cord-298525-hhcfrjrn 258 14 value value NN cord-298525-hhcfrjrn 258 15 of of IN cord-298525-hhcfrjrn 258 16 asymmetry asymmetry NN cord-298525-hhcfrjrn 258 17 in in IN cord-298525-hhcfrjrn 258 18 pupillary pupillary JJ cord-298525-hhcfrjrn 258 19 size size NN cord-298525-hhcfrjrn 258 20 in in IN cord-298525-hhcfrjrn 258 21 severe severe JJ cord-298525-hhcfrjrn 258 22 head head NN cord-298525-hhcfrjrn 258 23 injury injury NN cord-298525-hhcfrjrn 258 24 : : : cord-298525-hhcfrjrn 258 25 Relation relation NN cord-298525-hhcfrjrn 258 26 to to IN cord-298525-hhcfrjrn 258 27 lesion lesion NN cord-298525-hhcfrjrn 258 28 type type NN cord-298525-hhcfrjrn 258 29 and and CC cord-298525-hhcfrjrn 258 30 location location NN cord-298525-hhcfrjrn 259 1 The the DT cord-298525-hhcfrjrn 259 2 Pupillary Pupillary NNP cord-298525-hhcfrjrn 259 3 Light Light NNP cord-298525-hhcfrjrn 259 4 Reflex Reflex NNP cord-298525-hhcfrjrn 259 5 in in IN cord-298525-hhcfrjrn 259 6 Idiopathic idiopathic JJ cord-298525-hhcfrjrn 259 7 Intracranial Intracranial NNP cord-298525-hhcfrjrn 259 8 Hypertension Hypertension NNP cord-298525-hhcfrjrn 259 9 Quantitative Quantitative NNP cord-298525-hhcfrjrn 259 10 pupillometry pupillometry NN cord-298525-hhcfrjrn 259 11 , , , cord-298525-hhcfrjrn 259 12 a a DT cord-298525-hhcfrjrn 259 13 new new JJ cord-298525-hhcfrjrn 259 14 technology technology NN cord-298525-hhcfrjrn 259 15 : : : cord-298525-hhcfrjrn 259 16 Normative normative JJ cord-298525-hhcfrjrn 259 17 data datum NNS cord-298525-hhcfrjrn 259 18 and and CC cord-298525-hhcfrjrn 259 19 preliminary preliminary JJ cord-298525-hhcfrjrn 259 20 observations observation NNS cord-298525-hhcfrjrn 259 21 in in IN cord-298525-hhcfrjrn 259 22 patients patient NNS cord-298525-hhcfrjrn 259 23 with with IN cord-298525-hhcfrjrn 259 24 acute acute JJ cord-298525-hhcfrjrn 259 25 head head NN cord-298525-hhcfrjrn 259 26 injury injury NN cord-298525-hhcfrjrn 259 27 Pupillary Pupillary NNP cord-298525-hhcfrjrn 259 28 reactivity reactivity NN cord-298525-hhcfrjrn 259 29 as as IN cord-298525-hhcfrjrn 259 30 an an DT cord-298525-hhcfrjrn 259 31 early early JJ cord-298525-hhcfrjrn 259 32 indicator indicator NN cord-298525-hhcfrjrn 259 33 of of IN cord-298525-hhcfrjrn 259 34 increased increase VBN cord-298525-hhcfrjrn 259 35 intracranial intracranial JJ cord-298525-hhcfrjrn 259 36 pressure pressure NN cord-298525-hhcfrjrn 259 37 : : : cord-298525-hhcfrjrn 260 1 The the DT cord-298525-hhcfrjrn 260 2 introduction introduction NN cord-298525-hhcfrjrn 260 3 of of IN cord-298525-hhcfrjrn 260 4 the the DT cord-298525-hhcfrjrn 260 5 Neurological Neurological NNP cord-298525-hhcfrjrn 260 6 Pupil Pupil NNP cord-298525-hhcfrjrn 260 7 index index NN cord-298525-hhcfrjrn 260 8 Neurological neurological JJ cord-298525-hhcfrjrn 260 9 deterioration deterioration NN cord-298525-hhcfrjrn 260 10 as as IN cord-298525-hhcfrjrn 260 11 a a DT cord-298525-hhcfrjrn 260 12 potential potential JJ cord-298525-hhcfrjrn 260 13 alternative alternative JJ cord-298525-hhcfrjrn 260 14 endpoint endpoint NN cord-298525-hhcfrjrn 260 15 in in IN cord-298525-hhcfrjrn 260 16 human human JJ cord-298525-hhcfrjrn 260 17 clinical clinical JJ cord-298525-hhcfrjrn 260 18 trials trial NNS cord-298525-hhcfrjrn 260 19 of of IN cord-298525-hhcfrjrn 260 20 experimental experimental JJ cord-298525-hhcfrjrn 260 21 pharmacological pharmacological JJ cord-298525-hhcfrjrn 260 22 agents agent NNS cord-298525-hhcfrjrn 260 23 for for IN cord-298525-hhcfrjrn 260 24 treatment treatment NN cord-298525-hhcfrjrn 260 25 of of IN cord-298525-hhcfrjrn 260 26 severe severe JJ cord-298525-hhcfrjrn 260 27 traumatic traumatic JJ cord-298525-hhcfrjrn 260 28 brain brain NN cord-298525-hhcfrjrn 260 29 injuries injury NNS cord-298525-hhcfrjrn 261 1 Pupil pupil NN cord-298525-hhcfrjrn 261 2 examination examination NN cord-298525-hhcfrjrn 261 3 : : : cord-298525-hhcfrjrn 261 4 Validity validity NN cord-298525-hhcfrjrn 261 5 and and CC cord-298525-hhcfrjrn 261 6 clinical clinical JJ cord-298525-hhcfrjrn 261 7 utility utility NN cord-298525-hhcfrjrn 261 8 of of IN cord-298525-hhcfrjrn 261 9 an an DT cord-298525-hhcfrjrn 261 10 automated automate VBN cord-298525-hhcfrjrn 261 11 pupillometer pupillometer NNP cord-298525-hhcfrjrn 261 12 Evaluation evaluation NN cord-298525-hhcfrjrn 261 13 and and CC cord-298525-hhcfrjrn 261 14 significance significance NN cord-298525-hhcfrjrn 261 15 of of IN cord-298525-hhcfrjrn 261 16 the the DT cord-298525-hhcfrjrn 261 17 pupillary pupillary JJ cord-298525-hhcfrjrn 261 18 light light JJ cord-298525-hhcfrjrn 261 19 reflex reflex NN cord-298525-hhcfrjrn 261 20 in in IN cord-298525-hhcfrjrn 261 21 trauma trauma NN cord-298525-hhcfrjrn 261 22 patients patient NNS cord-298525-hhcfrjrn 261 23 Reliability Reliability NNP cord-298525-hhcfrjrn 261 24 of of IN cord-298525-hhcfrjrn 261 25 standard standard JJ cord-298525-hhcfrjrn 261 26 pupillometry pupillometry NNP cord-298525-hhcfrjrn 261 27 practice practice NN cord-298525-hhcfrjrn 261 28 in in IN cord-298525-hhcfrjrn 261 29 neurocritical neurocritical NNP cord-298525-hhcfrjrn 261 30 care care NN cord-298525-hhcfrjrn 261 31 : : : cord-298525-hhcfrjrn 261 32 An an DT cord-298525-hhcfrjrn 261 33 observational observational JJ cord-298525-hhcfrjrn 261 34 , , , cord-298525-hhcfrjrn 261 35 double double JJ cord-298525-hhcfrjrn 261 36 - - HYPH cord-298525-hhcfrjrn 261 37 blinded blinded JJ cord-298525-hhcfrjrn 261 38 study study NN cord-298525-hhcfrjrn 261 39 Pupillometric Pupillometric NNP cord-298525-hhcfrjrn 261 40 analysis analysis NN cord-298525-hhcfrjrn 261 41 of of IN cord-298525-hhcfrjrn 261 42 the the DT cord-298525-hhcfrjrn 261 43 ' ' `` cord-298525-hhcfrjrn 261 44 absent absent JJ cord-298525-hhcfrjrn 261 45 light light NN cord-298525-hhcfrjrn 261 46 reflex reflex NN cord-298525-hhcfrjrn 261 47 Interrater Interrater NNP cord-298525-hhcfrjrn 261 48 Reliability Reliability NNP cord-298525-hhcfrjrn 261 49 of of IN cord-298525-hhcfrjrn 261 50 Pupillary Pupillary NNP cord-298525-hhcfrjrn 261 51 Assessments Assessments NNPS cord-298525-hhcfrjrn 261 52 Symmetry Symmetry NNP cord-298525-hhcfrjrn 261 53 of of IN cord-298525-hhcfrjrn 261 54 the the DT cord-298525-hhcfrjrn 261 55 pupillary pupillary JJ cord-298525-hhcfrjrn 261 56 light light JJ cord-298525-hhcfrjrn 261 57 reflex reflex NN cord-298525-hhcfrjrn 261 58 and and CC cord-298525-hhcfrjrn 261 59 its -PRON- PRP$ cord-298525-hhcfrjrn 261 60 relationship relationship NN cord-298525-hhcfrjrn 261 61 to to IN cord-298525-hhcfrjrn 261 62 retinal retinal JJ cord-298525-hhcfrjrn 261 63 nerve nerve NN cord-298525-hhcfrjrn 261 64 fiber fiber NN cord-298525-hhcfrjrn 261 65 layer layer NN cord-298525-hhcfrjrn 261 66 thickness thickness NN cord-298525-hhcfrjrn 261 67 and and CC cord-298525-hhcfrjrn 261 68 visual visual JJ cord-298525-hhcfrjrn 261 69 field field NN cord-298525-hhcfrjrn 261 70 defect defect NN cord-298525-hhcfrjrn 261 71 Automated automate VBN cord-298525-hhcfrjrn 261 72 quantitative quantitative JJ cord-298525-hhcfrjrn 261 73 pupillometry pupillometry NN cord-298525-hhcfrjrn 261 74 for for IN cord-298525-hhcfrjrn 261 75 the the DT cord-298525-hhcfrjrn 261 76 prognostication prognostication NN cord-298525-hhcfrjrn 261 77 of of IN cord-298525-hhcfrjrn 261 78 coma coma NN cord-298525-hhcfrjrn 261 79 after after IN cord-298525-hhcfrjrn 261 80 cardiac cardiac JJ cord-298525-hhcfrjrn 261 81 arrest arrest NN cord-298525-hhcfrjrn 261 82 Quantitative quantitative JJ cord-298525-hhcfrjrn 261 83 pupillometry pupillometry NN cord-298525-hhcfrjrn 261 84 and and CC cord-298525-hhcfrjrn 261 85 transcranial transcranial JJ cord-298525-hhcfrjrn 261 86 Doppler Doppler NNP cord-298525-hhcfrjrn 261 87 measurements measurement NNS cord-298525-hhcfrjrn 261 88 in in IN cord-298525-hhcfrjrn 261 89 patients patient NNS cord-298525-hhcfrjrn 261 90 treated treat VBN cord-298525-hhcfrjrn 261 91 with with IN cord-298525-hhcfrjrn 261 92 hypothermia hypothermia NN cord-298525-hhcfrjrn 261 93 after after IN cord-298525-hhcfrjrn 261 94 cardiac cardiac JJ cord-298525-hhcfrjrn 261 95 arrest arrest NN cord-298525-hhcfrjrn 261 96 Hydrogen Hydrogen NNP cord-298525-hhcfrjrn 261 97 proton proton NN cord-298525-hhcfrjrn 261 98 magnetic magnetic JJ cord-298525-hhcfrjrn 261 99 resonance resonance NN cord-298525-hhcfrjrn 261 100 spectroscopy spectroscopy NN cord-298525-hhcfrjrn 261 101 in in IN cord-298525-hhcfrjrn 261 102 autism autism NN cord-298525-hhcfrjrn 261 103 : : : cord-298525-hhcfrjrn 262 1 Preliminary preliminary JJ cord-298525-hhcfrjrn 262 2 evidence evidence NN cord-298525-hhcfrjrn 262 3 of of IN cord-298525-hhcfrjrn 262 4 elevated elevated JJ cord-298525-hhcfrjrn 262 5 choline choline NN cord-298525-hhcfrjrn 262 6 / / SYM cord-298525-hhcfrjrn 262 7 creatine creatine NN cord-298525-hhcfrjrn 262 8 ratio ratio NN cord-298525-hhcfrjrn 262 9 Nicotinic Nicotinic NNP cord-298525-hhcfrjrn 262 10 receptor receptor NN cord-298525-hhcfrjrn 262 11 abnormalities abnormality NNS cord-298525-hhcfrjrn 262 12 in in IN cord-298525-hhcfrjrn 262 13 the the DT cord-298525-hhcfrjrn 262 14 cerebellar cerebellar JJ cord-298525-hhcfrjrn 262 15 cortex cortex NN cord-298525-hhcfrjrn 262 16 in in IN cord-298525-hhcfrjrn 262 17 autism autism NN cord-298525-hhcfrjrn 262 18 Cholinergic cholinergic JJ cord-298525-hhcfrjrn 262 19 activity activity NN cord-298525-hhcfrjrn 262 20 in in IN cord-298525-hhcfrjrn 262 21 autism autism NN cord-298525-hhcfrjrn 262 22 : : : cord-298525-hhcfrjrn 263 1 Abnormalities abnormality NNS cord-298525-hhcfrjrn 263 2 in in IN cord-298525-hhcfrjrn 263 3 the the DT cord-298525-hhcfrjrn 263 4 cerebral cerebral JJ cord-298525-hhcfrjrn 263 5 cortex cortex NN cord-298525-hhcfrjrn 263 6 and and CC cord-298525-hhcfrjrn 263 7 basal basal NN cord-298525-hhcfrjrn 263 8 forebrain forebrain NN cord-298525-hhcfrjrn 263 9 Acetylcholine Acetylcholine NNP cord-298525-hhcfrjrn 263 10 elevation elevation NN cord-298525-hhcfrjrn 263 11 relieves relieve VBZ cord-298525-hhcfrjrn 263 12 cognitive cognitive JJ cord-298525-hhcfrjrn 263 13 rigidity rigidity NN cord-298525-hhcfrjrn 263 14 and and CC cord-298525-hhcfrjrn 263 15 social social JJ cord-298525-hhcfrjrn 263 16 deficiency deficiency NN cord-298525-hhcfrjrn 263 17 in in IN cord-298525-hhcfrjrn 263 18 a a DT cord-298525-hhcfrjrn 263 19 mouse mouse NN cord-298525-hhcfrjrn 263 20 model model NN cord-298525-hhcfrjrn 263 21 of of IN cord-298525-hhcfrjrn 263 22 autism autism NN cord-298525-hhcfrjrn 264 1 The the DT cord-298525-hhcfrjrn 264 2 BTBR BTBR NNP cord-298525-hhcfrjrn 264 3 mouse mouse NN cord-298525-hhcfrjrn 264 4 model model NN cord-298525-hhcfrjrn 264 5 of of IN cord-298525-hhcfrjrn 264 6 autism autism NN cord-298525-hhcfrjrn 264 7 spectrum spectrum NN cord-298525-hhcfrjrn 264 8 disorders disorder NNS cord-298525-hhcfrjrn 264 9 has have VBZ cord-298525-hhcfrjrn 264 10 learning learn VBG cord-298525-hhcfrjrn 264 11 and and CC cord-298525-hhcfrjrn 264 12 attentional attentional JJ cord-298525-hhcfrjrn 264 13 impairments impairment NNS cord-298525-hhcfrjrn 264 14 and and CC cord-298525-hhcfrjrn 264 15 alterations alteration NNS cord-298525-hhcfrjrn 264 16 in in IN cord-298525-hhcfrjrn 264 17 acetylcholine acetylcholine NN cord-298525-hhcfrjrn 264 18 and and CC cord-298525-hhcfrjrn 264 19 kynurenic kynurenic NNP cord-298525-hhcfrjrn 264 20 acid acid NN cord-298525-hhcfrjrn 264 21 in in IN cord-298525-hhcfrjrn 264 22 prefrontal prefrontal NNP cord-298525-hhcfrjrn 264 23 cortex cortex NNP cord-298525-hhcfrjrn 264 24 Genetic genetic JJ cord-298525-hhcfrjrn 264 25 and and CC cord-298525-hhcfrjrn 264 26 functional functional JJ cord-298525-hhcfrjrn 264 27 analyses analysis NNS cord-298525-hhcfrjrn 264 28 of of IN cord-298525-hhcfrjrn 264 29 SHANK2 SHANK2 NNS cord-298525-hhcfrjrn 264 30 mutations mutation NNS cord-298525-hhcfrjrn 264 31 suggest suggest VBP cord-298525-hhcfrjrn 264 32 a a DT cord-298525-hhcfrjrn 264 33 multiple multiple JJ cord-298525-hhcfrjrn 264 34 hit hit NN cord-298525-hhcfrjrn 264 35 model model NN cord-298525-hhcfrjrn 264 36 of of IN cord-298525-hhcfrjrn 264 37 autism autism NN cord-298525-hhcfrjrn 264 38 spectrum spectrum NNP cord-298525-hhcfrjrn 264 39 disorders disorders NNPS cord-298525-hhcfrjrn 264 40 Association Association NNP cord-298525-hhcfrjrn 264 41 between between IN cord-298525-hhcfrjrn 264 42 pupillary pupillary JJ cord-298525-hhcfrjrn 264 43 light light JJ cord-298525-hhcfrjrn 264 44 reflex reflex NN cord-298525-hhcfrjrn 264 45 and and CC cord-298525-hhcfrjrn 264 46 sensory sensory JJ cord-298525-hhcfrjrn 264 47 behaviors behavior NNS cord-298525-hhcfrjrn 264 48 in in IN cord-298525-hhcfrjrn 264 49 children child NNS cord-298525-hhcfrjrn 264 50 with with IN cord-298525-hhcfrjrn 264 51 autism autism NN cord-298525-hhcfrjrn 264 52 spectrum spectrum NN cord-298525-hhcfrjrn 264 53 disorders disorder NNS cord-298525-hhcfrjrn 264 54 Atypical Atypical NNP cord-298525-hhcfrjrn 264 55 pupillary pupillary JJ cord-298525-hhcfrjrn 264 56 light light JJ cord-298525-hhcfrjrn 264 57 reflex reflex NN cord-298525-hhcfrjrn 264 58 and and CC cord-298525-hhcfrjrn 264 59 heart heart NN cord-298525-hhcfrjrn 264 60 rate rate NN cord-298525-hhcfrjrn 264 61 variability variability NN cord-298525-hhcfrjrn 264 62 in in IN cord-298525-hhcfrjrn 264 63 children child NNS cord-298525-hhcfrjrn 264 64 with with IN cord-298525-hhcfrjrn 264 65 autism autism NN cord-298525-hhcfrjrn 264 66 spectrum spectrum NN cord-298525-hhcfrjrn 264 67 disorder disorder NN cord-298525-hhcfrjrn 265 1 Hypersensitive hypersensitive JJ cord-298525-hhcfrjrn 265 2 pupillary pupillary JJ cord-298525-hhcfrjrn 265 3 light light JJ cord-298525-hhcfrjrn 265 4 reflex reflex NN cord-298525-hhcfrjrn 265 5 in in IN cord-298525-hhcfrjrn 265 6 infants infant NNS cord-298525-hhcfrjrn 265 7 at at IN cord-298525-hhcfrjrn 265 8 risk risk NN cord-298525-hhcfrjrn 265 9 for for IN cord-298525-hhcfrjrn 265 10 autism autism NN cord-298525-hhcfrjrn 266 1 White white JJ cord-298525-hhcfrjrn 266 2 matter matter NN cord-298525-hhcfrjrn 266 3 maturation maturation NN cord-298525-hhcfrjrn 266 4 in in IN cord-298525-hhcfrjrn 266 5 visual visual JJ cord-298525-hhcfrjrn 266 6 and and CC cord-298525-hhcfrjrn 266 7 motor motor NN cord-298525-hhcfrjrn 266 8 areas area NNS cord-298525-hhcfrjrn 266 9 predicts predict VBZ cord-298525-hhcfrjrn 266 10 the the DT cord-298525-hhcfrjrn 266 11 latency latency NN cord-298525-hhcfrjrn 266 12 of of IN cord-298525-hhcfrjrn 266 13 visual visual JJ cord-298525-hhcfrjrn 266 14 activation activation NN cord-298525-hhcfrjrn 266 15 in in IN cord-298525-hhcfrjrn 266 16 children child NNS cord-298525-hhcfrjrn 266 17 Accelerated accelerate VBD cord-298525-hhcfrjrn 266 18 maturation maturation NN cord-298525-hhcfrjrn 266 19 of of IN cord-298525-hhcfrjrn 266 20 white white JJ cord-298525-hhcfrjrn 266 21 matter matter NN cord-298525-hhcfrjrn 266 22 in in IN cord-298525-hhcfrjrn 266 23 young young JJ cord-298525-hhcfrjrn 266 24 children child NNS cord-298525-hhcfrjrn 266 25 with with IN cord-298525-hhcfrjrn 266 26 autism autism NN cord-298525-hhcfrjrn 266 27 : : : cord-298525-hhcfrjrn 266 28 A a DT cord-298525-hhcfrjrn 266 29 high high JJ cord-298525-hhcfrjrn 266 30 b b NN cord-298525-hhcfrjrn 266 31 value value NN cord-298525-hhcfrjrn 266 32 DWI DWI NNP cord-298525-hhcfrjrn 266 33 study study NN cord-298525-hhcfrjrn 266 34 Abnormal abnormal JJ cord-298525-hhcfrjrn 266 35 early early JJ cord-298525-hhcfrjrn 266 36 brain brain NN cord-298525-hhcfrjrn 266 37 development development NN cord-298525-hhcfrjrn 266 38 in in IN cord-298525-hhcfrjrn 266 39 autism autism NN cord-298525-hhcfrjrn 266 40 Unusual unusual JJ cord-298525-hhcfrjrn 266 41 brain brain NN cord-298525-hhcfrjrn 266 42 growth growth NN cord-298525-hhcfrjrn 266 43 patterns pattern NNS cord-298525-hhcfrjrn 266 44 in in IN cord-298525-hhcfrjrn 266 45 early early JJ cord-298525-hhcfrjrn 266 46 life life NN cord-298525-hhcfrjrn 266 47 in in IN cord-298525-hhcfrjrn 266 48 patients patient NNS cord-298525-hhcfrjrn 266 49 with with IN cord-298525-hhcfrjrn 266 50 autistic autistic JJ cord-298525-hhcfrjrn 266 51 disorder disorder NN cord-298525-hhcfrjrn 266 52 : : : cord-298525-hhcfrjrn 267 1 An an DT cord-298525-hhcfrjrn 267 2 MRI MRI NNP cord-298525-hhcfrjrn 267 3 study study NN cord-298525-hhcfrjrn 267 4 Abnormal abnormal JJ cord-298525-hhcfrjrn 267 5 white white JJ cord-298525-hhcfrjrn 267 6 matter matter NN cord-298525-hhcfrjrn 267 7 integrity integrity NN cord-298525-hhcfrjrn 267 8 in in IN cord-298525-hhcfrjrn 267 9 young young JJ cord-298525-hhcfrjrn 267 10 children child NNS cord-298525-hhcfrjrn 267 11 with with IN cord-298525-hhcfrjrn 267 12 autism autism NN cord-298525-hhcfrjrn 267 13 Differences difference NNS cord-298525-hhcfrjrn 267 14 in in IN cord-298525-hhcfrjrn 267 15 white white JJ cord-298525-hhcfrjrn 267 16 matter matter NN cord-298525-hhcfrjrn 267 17 fiber fiber NN cord-298525-hhcfrjrn 267 18 tract tract NN cord-298525-hhcfrjrn 267 19 development development NN cord-298525-hhcfrjrn 267 20 present present JJ cord-298525-hhcfrjrn 267 21 from from IN cord-298525-hhcfrjrn 267 22 6 6 CD cord-298525-hhcfrjrn 267 23 to to TO cord-298525-hhcfrjrn 267 24 24 24 CD cord-298525-hhcfrjrn 267 25 months month NNS cord-298525-hhcfrjrn 267 26 in in IN cord-298525-hhcfrjrn 267 27 infants infant NNS cord-298525-hhcfrjrn 267 28 with with IN cord-298525-hhcfrjrn 267 29 autism autism NN cord-298525-hhcfrjrn 267 30 Brain Brain NNP cord-298525-hhcfrjrn 267 31 connectivity connectivity NN cord-298525-hhcfrjrn 267 32 and and CC cord-298525-hhcfrjrn 267 33 high high JJ cord-298525-hhcfrjrn 267 34 functioning function VBG cord-298525-hhcfrjrn 267 35 autism autism NN cord-298525-hhcfrjrn 267 36 : : : cord-298525-hhcfrjrn 268 1 A a DT cord-298525-hhcfrjrn 268 2 promising promising JJ cord-298525-hhcfrjrn 268 3 path path NN cord-298525-hhcfrjrn 268 4 of of IN cord-298525-hhcfrjrn 268 5 research research NN cord-298525-hhcfrjrn 268 6 that that WDT cord-298525-hhcfrjrn 268 7 needs need VBZ cord-298525-hhcfrjrn 268 8 refined refined JJ cord-298525-hhcfrjrn 268 9 models model NNS cord-298525-hhcfrjrn 268 10 , , , cord-298525-hhcfrjrn 268 11 methodological methodological JJ cord-298525-hhcfrjrn 268 12 convergence convergence NN cord-298525-hhcfrjrn 268 13 , , , cord-298525-hhcfrjrn 268 14 and and CC cord-298525-hhcfrjrn 268 15 stronger strong JJR cord-298525-hhcfrjrn 268 16 behavioral behavioral JJ cord-298525-hhcfrjrn 268 17 links link NNS cord-298525-hhcfrjrn 268 18 Brain Brain NNP cord-298525-hhcfrjrn 268 19 growth growth NN cord-298525-hhcfrjrn 268 20 across across IN cord-298525-hhcfrjrn 268 21 the the DT cord-298525-hhcfrjrn 268 22 life life NN cord-298525-hhcfrjrn 268 23 span span NN cord-298525-hhcfrjrn 268 24 in in IN cord-298525-hhcfrjrn 268 25 autism autism NN cord-298525-hhcfrjrn 268 26 : : : cord-298525-hhcfrjrn 269 1 Age age NN cord-298525-hhcfrjrn 269 2 - - HYPH cord-298525-hhcfrjrn 269 3 specific specific JJ cord-298525-hhcfrjrn 269 4 changes change NNS cord-298525-hhcfrjrn 269 5 in in IN cord-298525-hhcfrjrn 269 6 anatomical anatomical JJ cord-298525-hhcfrjrn 269 7 pathology pathology NN cord-298525-hhcfrjrn 269 8 Evidence evidence NN cord-298525-hhcfrjrn 269 9 for for IN cord-298525-hhcfrjrn 269 10 cortical cortical JJ cord-298525-hhcfrjrn 269 11 dysfunction dysfunction NN cord-298525-hhcfrjrn 269 12 in in IN cord-298525-hhcfrjrn 269 13 autism autism NN cord-298525-hhcfrjrn 269 14 : : : cord-298525-hhcfrjrn 270 1 A a DT cord-298525-hhcfrjrn 270 2 proton proton NN cord-298525-hhcfrjrn 270 3 magnetic magnetic JJ cord-298525-hhcfrjrn 270 4 resonance resonance NN cord-298525-hhcfrjrn 270 5 spectroscopic spectroscopic JJ cord-298525-hhcfrjrn 270 6 imaging imaging NN cord-298525-hhcfrjrn 270 7 study study NN cord-298525-hhcfrjrn 270 8 Pupil Pupil NNP cord-298525-hhcfrjrn 270 9 function function NN cord-298525-hhcfrjrn 270 10 as as IN cord-298525-hhcfrjrn 270 11 an an DT cord-298525-hhcfrjrn 270 12 indicator indicator NN cord-298525-hhcfrjrn 270 13 for for IN cord-298525-hhcfrjrn 270 14 being be VBG cord-298525-hhcfrjrn 270 15 under under IN cord-298525-hhcfrjrn 270 16 the the DT cord-298525-hhcfrjrn 270 17 influence influence NN cord-298525-hhcfrjrn 270 18 of of IN cord-298525-hhcfrjrn 270 19 central central JJ cord-298525-hhcfrjrn 270 20 nervous nervous JJ cord-298525-hhcfrjrn 270 21 system system NN cord-298525-hhcfrjrn 270 22 - - HYPH cord-298525-hhcfrjrn 270 23 acting act VBG cord-298525-hhcfrjrn 270 24 substances substance NNS cord-298525-hhcfrjrn 270 25 from from IN cord-298525-hhcfrjrn 270 26 a a DT cord-298525-hhcfrjrn 270 27 traffic traffic NN cord-298525-hhcfrjrn 270 28 - - HYPH cord-298525-hhcfrjrn 270 29 medicine medicine NN cord-298525-hhcfrjrn 270 30 perspective perspective NN cord-298525-hhcfrjrn 271 1 The the DT cord-298525-hhcfrjrn 271 2 potential potential NN cord-298525-hhcfrjrn 271 3 of of IN cord-298525-hhcfrjrn 271 4 infrared infrared JJ cord-298525-hhcfrjrn 271 5 pupillography pupillography NN cord-298525-hhcfrjrn 271 6 in in IN cord-298525-hhcfrjrn 271 7 routine routine JJ cord-298525-hhcfrjrn 271 8 police police NN cord-298525-hhcfrjrn 271 9 traffic traffic NN cord-298525-hhcfrjrn 271 10 checks check VBZ cord-298525-hhcfrjrn 271 11 Pupil pupil NN cord-298525-hhcfrjrn 271 12 function function NN cord-298525-hhcfrjrn 271 13 as as IN cord-298525-hhcfrjrn 271 14 a a DT cord-298525-hhcfrjrn 271 15 parameter parameter NN cord-298525-hhcfrjrn 271 16 for for IN cord-298525-hhcfrjrn 271 17 assessing assess VBG cord-298525-hhcfrjrn 271 18 impairment impairment NN cord-298525-hhcfrjrn 271 19 of of IN cord-298525-hhcfrjrn 271 20 the the DT cord-298525-hhcfrjrn 271 21 central central JJ cord-298525-hhcfrjrn 271 22 nervous nervous JJ cord-298525-hhcfrjrn 271 23 system system NN cord-298525-hhcfrjrn 271 24 from from IN cord-298525-hhcfrjrn 271 25 a a DT cord-298525-hhcfrjrn 271 26 traffic traffic NN cord-298525-hhcfrjrn 271 27 - - HYPH cord-298525-hhcfrjrn 271 28 medicine medicine NN cord-298525-hhcfrjrn 271 29 perspective perspective NN cord-298525-hhcfrjrn 271 30 Drug Drug NNP cord-298525-hhcfrjrn 271 31 Recognition Recognition NNP cord-298525-hhcfrjrn 271 32 Expert Expert NNP cord-298525-hhcfrjrn 271 33 ( ( -LRB- cord-298525-hhcfrjrn 271 34 DRE DRE NNP cord-298525-hhcfrjrn 271 35 ) ) -RRB- cord-298525-hhcfrjrn 271 36 examination examination NN cord-298525-hhcfrjrn 271 37 characteristics characteristic NNS cord-298525-hhcfrjrn 271 38 of of IN cord-298525-hhcfrjrn 271 39 cannabis cannabis NN cord-298525-hhcfrjrn 271 40 impairment impairment NN cord-298525-hhcfrjrn 272 1 The the DT cord-298525-hhcfrjrn 272 2 Drug Drug NNP cord-298525-hhcfrjrn 272 3 Evaluation Evaluation NNP cord-298525-hhcfrjrn 272 4 Classification Classification NNP cord-298525-hhcfrjrn 272 5 Program Program NNP cord-298525-hhcfrjrn 272 6 : : : cord-298525-hhcfrjrn 272 7 Using use VBG cord-298525-hhcfrjrn 272 8 ocular ocular JJ cord-298525-hhcfrjrn 272 9 and and CC cord-298525-hhcfrjrn 272 10 other other JJ cord-298525-hhcfrjrn 272 11 signs sign NNS cord-298525-hhcfrjrn 272 12 to to TO cord-298525-hhcfrjrn 272 13 detect detect VB cord-298525-hhcfrjrn 272 14 drug drug NN cord-298525-hhcfrjrn 272 15 intoxication intoxication NN cord-298525-hhcfrjrn 272 16 Utility utility NN cord-298525-hhcfrjrn 272 17 of of IN cord-298525-hhcfrjrn 272 18 dynamic dynamic JJ cord-298525-hhcfrjrn 272 19 pupillometry pupillometry NN cord-298525-hhcfrjrn 272 20 in in IN cord-298525-hhcfrjrn 272 21 alcohol alcohol NN cord-298525-hhcfrjrn 272 22 testing testing NN cord-298525-hhcfrjrn 272 23 on on IN cord-298525-hhcfrjrn 272 24 drivers driver NNS cord-298525-hhcfrjrn 272 25 Effects effect NNS cord-298525-hhcfrjrn 272 26 of of IN cord-298525-hhcfrjrn 272 27 abused abuse VBN cord-298525-hhcfrjrn 272 28 drugs drug NNS cord-298525-hhcfrjrn 272 29 on on IN cord-298525-hhcfrjrn 272 30 psychomotor psychomotor NN cord-298525-hhcfrjrn 272 31 performance performance NN cord-298525-hhcfrjrn 273 1 The the DT cord-298525-hhcfrjrn 273 2 rapid rapid JJ cord-298525-hhcfrjrn 273 3 eye eye NN cord-298525-hhcfrjrn 273 4 test test NN cord-298525-hhcfrjrn 273 5 to to TO cord-298525-hhcfrjrn 273 6 detect detect VB cord-298525-hhcfrjrn 273 7 drug drug NN cord-298525-hhcfrjrn 273 8 abuse abuse NN cord-298525-hhcfrjrn 273 9 Alcohol Alcohol NNP cord-298525-hhcfrjrn 273 10 has have VBZ cord-298525-hhcfrjrn 273 11 a a DT cord-298525-hhcfrjrn 273 12 dose dose NN cord-298525-hhcfrjrn 273 13 - - HYPH cord-298525-hhcfrjrn 273 14 related relate VBN cord-298525-hhcfrjrn 273 15 effect effect NN cord-298525-hhcfrjrn 273 16 on on IN cord-298525-hhcfrjrn 273 17 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 273 18 nerve nerve NN cord-298525-hhcfrjrn 273 19 activity activity NN cord-298525-hhcfrjrn 273 20 during during IN cord-298525-hhcfrjrn 273 21 sleep sleep NN cord-298525-hhcfrjrn 274 1 Diverse diverse JJ cord-298525-hhcfrjrn 274 2 autonomic autonomic JJ cord-298525-hhcfrjrn 274 3 regulation regulation NN cord-298525-hhcfrjrn 274 4 of of IN cord-298525-hhcfrjrn 274 5 pupillary pupillary JJ cord-298525-hhcfrjrn 274 6 function function NN cord-298525-hhcfrjrn 274 7 and and CC cord-298525-hhcfrjrn 274 8 the the DT cord-298525-hhcfrjrn 274 9 cardiovascular cardiovascular JJ cord-298525-hhcfrjrn 274 10 system system NN cord-298525-hhcfrjrn 274 11 during during IN cord-298525-hhcfrjrn 274 12 alcohol alcohol NN cord-298525-hhcfrjrn 274 13 withdrawal withdrawal NN cord-298525-hhcfrjrn 274 14 Alcohol Alcohol NNP cord-298525-hhcfrjrn 274 15 withdrawal withdrawal NN cord-298525-hhcfrjrn 274 16 reaction reaction NN cord-298525-hhcfrjrn 274 17 as as IN cord-298525-hhcfrjrn 274 18 a a DT cord-298525-hhcfrjrn 274 19 result result NN cord-298525-hhcfrjrn 274 20 of of IN cord-298525-hhcfrjrn 274 21 adaptive adaptive JJ cord-298525-hhcfrjrn 274 22 changes change NNS cord-298525-hhcfrjrn 274 23 of of IN cord-298525-hhcfrjrn 274 24 excitatory excitatory JJ cord-298525-hhcfrjrn 274 25 amino amino NN cord-298525-hhcfrjrn 274 26 acid acid NN cord-298525-hhcfrjrn 274 27 receptors receptor NNS cord-298525-hhcfrjrn 274 28 Induction Induction NNP cord-298525-hhcfrjrn 274 29 of of IN cord-298525-hhcfrjrn 274 30 Fos Fos NNP cord-298525-hhcfrjrn 274 31 - - HYPH cord-298525-hhcfrjrn 274 32 like like JJ cord-298525-hhcfrjrn 274 33 proteins protein NNS cord-298525-hhcfrjrn 274 34 and and CC cord-298525-hhcfrjrn 274 35 ultrasonic ultrasonic JJ cord-298525-hhcfrjrn 274 36 vocalizations vocalization NNS cord-298525-hhcfrjrn 274 37 during during IN cord-298525-hhcfrjrn 274 38 ethanol ethanol NN cord-298525-hhcfrjrn 274 39 withdrawal withdrawal NN cord-298525-hhcfrjrn 274 40 : : : cord-298525-hhcfrjrn 274 41 Further further JJ cord-298525-hhcfrjrn 274 42 evidence evidence NN cord-298525-hhcfrjrn 274 43 for for IN cord-298525-hhcfrjrn 274 44 withdrawal withdrawal NN cord-298525-hhcfrjrn 274 45 - - HYPH cord-298525-hhcfrjrn 274 46 induced induce VBN cord-298525-hhcfrjrn 274 47 anxiety anxiety NN cord-298525-hhcfrjrn 274 48 Acute acute JJ cord-298525-hhcfrjrn 274 49 and and CC cord-298525-hhcfrjrn 274 50 residual residual JJ cord-298525-hhcfrjrn 274 51 effects effect NNS cord-298525-hhcfrjrn 274 52 of of IN cord-298525-hhcfrjrn 274 53 marijuana marijuana NN cord-298525-hhcfrjrn 274 54 in in IN cord-298525-hhcfrjrn 274 55 humans human NNS cord-298525-hhcfrjrn 274 56 Effects effect NNS cord-298525-hhcfrjrn 274 57 of of IN cord-298525-hhcfrjrn 274 58 MDMA MDMA NNP cord-298525-hhcfrjrn 274 59 alone alone RB cord-298525-hhcfrjrn 274 60 and and CC cord-298525-hhcfrjrn 274 61 after after IN cord-298525-hhcfrjrn 274 62 pretreatment pretreatment NN cord-298525-hhcfrjrn 274 63 with with IN cord-298525-hhcfrjrn 274 64 reboxetine reboxetine NNP cord-298525-hhcfrjrn 274 65 , , , cord-298525-hhcfrjrn 274 66 duloxetine duloxetine NN cord-298525-hhcfrjrn 274 67 , , , cord-298525-hhcfrjrn 274 68 clonidine clonidine NN cord-298525-hhcfrjrn 274 69 , , , cord-298525-hhcfrjrn 274 70 carvedilol carvedilol NN cord-298525-hhcfrjrn 274 71 , , , cord-298525-hhcfrjrn 274 72 and and CC cord-298525-hhcfrjrn 274 73 doxazosin doxazosin NNP cord-298525-hhcfrjrn 274 74 on on IN cord-298525-hhcfrjrn 274 75 pupillary pupillary JJ cord-298525-hhcfrjrn 274 76 light light JJ cord-298525-hhcfrjrn 274 77 reflex reflex NN cord-298525-hhcfrjrn 274 78 Pupillary Pupillary NNP cord-298525-hhcfrjrn 274 79 constriction constriction NN cord-298525-hhcfrjrn 274 80 after after IN cord-298525-hhcfrjrn 274 81 marijuana marijuana NN cord-298525-hhcfrjrn 274 82 smoking smoke VBG cord-298525-hhcfrjrn 274 83 The the DT cord-298525-hhcfrjrn 274 84 action action NN cord-298525-hhcfrjrn 274 85 of of IN cord-298525-hhcfrjrn 274 86 botulinum botulinum NN cord-298525-hhcfrjrn 274 87 toxin toxin NN cord-298525-hhcfrjrn 274 88 on on IN cord-298525-hhcfrjrn 274 89 the the DT cord-298525-hhcfrjrn 274 90 neuro neuro JJ cord-298525-hhcfrjrn 274 91 - - HYPH cord-298525-hhcfrjrn 274 92 muscular muscular JJ cord-298525-hhcfrjrn 274 93 junction junction NN cord-298525-hhcfrjrn 275 1 The the DT cord-298525-hhcfrjrn 275 2 pharmacological pharmacological JJ cord-298525-hhcfrjrn 275 3 mechanism mechanism NN cord-298525-hhcfrjrn 275 4 of of IN cord-298525-hhcfrjrn 275 5 botulism botulism NN cord-298525-hhcfrjrn 275 6 Reversible reversible JJ cord-298525-hhcfrjrn 275 7 pupillary pupillary JJ cord-298525-hhcfrjrn 275 8 dilation dilation NN cord-298525-hhcfrjrn 275 9 following follow VBG cord-298525-hhcfrjrn 275 10 botulinum botulinum NN cord-298525-hhcfrjrn 275 11 toxin toxin NN cord-298525-hhcfrjrn 275 12 injection injection NN cord-298525-hhcfrjrn 275 13 to to IN cord-298525-hhcfrjrn 275 14 the the DT cord-298525-hhcfrjrn 275 15 lateral lateral JJ cord-298525-hhcfrjrn 275 16 rectus rectus NN cord-298525-hhcfrjrn 275 17 Ophthalmic ophthalmic JJ cord-298525-hhcfrjrn 275 18 manifestations manifestation NNS cord-298525-hhcfrjrn 275 19 in in IN cord-298525-hhcfrjrn 275 20 18 18 CD cord-298525-hhcfrjrn 275 21 patients patient NNS cord-298525-hhcfrjrn 275 22 with with IN cord-298525-hhcfrjrn 275 23 botulism botulism NN cord-298525-hhcfrjrn 275 24 diagnosed diagnose VBN cord-298525-hhcfrjrn 275 25 in in IN cord-298525-hhcfrjrn 275 26 Porto Porto NNP cord-298525-hhcfrjrn 275 27 , , , cord-298525-hhcfrjrn 275 28 Portugal Portugal NNP cord-298525-hhcfrjrn 275 29 between between IN cord-298525-hhcfrjrn 275 30 1998 1998 CD cord-298525-hhcfrjrn 275 31 and and CC cord-298525-hhcfrjrn 275 32 Unilateral unilateral JJ cord-298525-hhcfrjrn 275 33 transient transient JJ cord-298525-hhcfrjrn 275 34 mydriasis mydriasis NN cord-298525-hhcfrjrn 275 35 and and CC cord-298525-hhcfrjrn 275 36 ptosis ptosis NN cord-298525-hhcfrjrn 275 37 after after IN cord-298525-hhcfrjrn 275 38 botulinum botulinum NN cord-298525-hhcfrjrn 275 39 toxin toxin NN cord-298525-hhcfrjrn 275 40 injection injection NN cord-298525-hhcfrjrn 275 41 for for IN cord-298525-hhcfrjrn 275 42 a a DT cord-298525-hhcfrjrn 275 43 cosmetic cosmetic JJ cord-298525-hhcfrjrn 275 44 procedure procedure NN cord-298525-hhcfrjrn 275 45 Pediatric Pediatric NNP cord-298525-hhcfrjrn 275 46 Eye Eye NNP cord-298525-hhcfrjrn 275 47 Disease Disease NNP cord-298525-hhcfrjrn 275 48 Investigator Investigator NNP cord-298525-hhcfrjrn 275 49 Group Group NNP cord-298525-hhcfrjrn 275 50 . . . cord-298525-hhcfrjrn 276 1 Tonic tonic NN cord-298525-hhcfrjrn 276 2 pupil pupil NN cord-298525-hhcfrjrn 276 3 after after IN cord-298525-hhcfrjrn 276 4 botulinum botulinum NN cord-298525-hhcfrjrn 276 5 toxin toxin NN cord-298525-hhcfrjrn 276 6 - - : cord-298525-hhcfrjrn 276 7 A a DT cord-298525-hhcfrjrn 276 8 injection injection NN cord-298525-hhcfrjrn 276 9 for for IN cord-298525-hhcfrjrn 276 10 treatment treatment NN cord-298525-hhcfrjrn 276 11 of of IN cord-298525-hhcfrjrn 276 12 esotropia esotropia NN cord-298525-hhcfrjrn 276 13 in in IN cord-298525-hhcfrjrn 276 14 children child NNS cord-298525-hhcfrjrn 276 15 Tolerance tolerance NN cord-298525-hhcfrjrn 276 16 to to IN cord-298525-hhcfrjrn 276 17 the the DT cord-298525-hhcfrjrn 276 18 miotic miotic JJ cord-298525-hhcfrjrn 276 19 effect effect NN cord-298525-hhcfrjrn 276 20 of of IN cord-298525-hhcfrjrn 276 21 sarin sarin NN cord-298525-hhcfrjrn 276 22 vapor vapor NN cord-298525-hhcfrjrn 276 23 in in IN cord-298525-hhcfrjrn 276 24 rats rat NNS cord-298525-hhcfrjrn 276 25 after after IN cord-298525-hhcfrjrn 276 26 multiple multiple JJ cord-298525-hhcfrjrn 276 27 low low JJ cord-298525-hhcfrjrn 276 28 - - HYPH cord-298525-hhcfrjrn 276 29 level level NN cord-298525-hhcfrjrn 276 30 exposures exposure NNS cord-298525-hhcfrjrn 276 31 Miotic miotic JJ cord-298525-hhcfrjrn 276 32 tolerance tolerance NN cord-298525-hhcfrjrn 276 33 to to IN cord-298525-hhcfrjrn 276 34 sarin sarin NN cord-298525-hhcfrjrn 276 35 vapor vapor NN cord-298525-hhcfrjrn 276 36 exposure exposure NN cord-298525-hhcfrjrn 276 37 : : : cord-298525-hhcfrjrn 276 38 Role role NN cord-298525-hhcfrjrn 276 39 of of IN cord-298525-hhcfrjrn 276 40 the the DT cord-298525-hhcfrjrn 276 41 sympathetic sympathetic JJ cord-298525-hhcfrjrn 276 42 and and CC cord-298525-hhcfrjrn 276 43 parasympathetic parasympathetic JJ cord-298525-hhcfrjrn 276 44 nervous nervous JJ cord-298525-hhcfrjrn 276 45 systems system NNS cord-298525-hhcfrjrn 276 46 Sarin Sarin NNP cord-298525-hhcfrjrn 276 47 experiences experience NNS cord-298525-hhcfrjrn 276 48 in in IN cord-298525-hhcfrjrn 276 49 Japan Japan NNP cord-298525-hhcfrjrn 276 50 : : : cord-298525-hhcfrjrn 276 51 Acute acute JJ cord-298525-hhcfrjrn 276 52 toxicity toxicity NN cord-298525-hhcfrjrn 276 53 and and CC cord-298525-hhcfrjrn 276 54 long long JJ cord-298525-hhcfrjrn 276 55 - - HYPH cord-298525-hhcfrjrn 276 56 term term NN cord-298525-hhcfrjrn 276 57 effects effect NNS cord-298525-hhcfrjrn 276 58 Vision vision NN cord-298525-hhcfrjrn 276 59 and and CC cord-298525-hhcfrjrn 276 60 ocular ocular JJ cord-298525-hhcfrjrn 276 61 changes change NNS cord-298525-hhcfrjrn 276 62 following follow VBG cord-298525-hhcfrjrn 276 63 accidental accidental JJ cord-298525-hhcfrjrn 276 64 exposure exposure NN cord-298525-hhcfrjrn 276 65 to to IN cord-298525-hhcfrjrn 276 66 organophosphates organophosphate NNS cord-298525-hhcfrjrn 276 67 Factors factor NNS cord-298525-hhcfrjrn 276 68 determining determine VBG cord-298525-hhcfrjrn 276 69 the the DT cord-298525-hhcfrjrn 276 70 potency potency NN cord-298525-hhcfrjrn 276 71 of of IN cord-298525-hhcfrjrn 276 72 cholinomimetic cholinomimetic JJ cord-298525-hhcfrjrn 276 73 miotic miotic JJ cord-298525-hhcfrjrn 276 74 drugs drug NNS cord-298525-hhcfrjrn 276 75 and and CC cord-298525-hhcfrjrn 276 76 their -PRON- PRP$ cord-298525-hhcfrjrn 276 77 effect effect NN cord-298525-hhcfrjrn 276 78 upon upon IN cord-298525-hhcfrjrn 276 79 the the DT cord-298525-hhcfrjrn 276 80 light light JJ cord-298525-hhcfrjrn 276 81 reflex reflex NN cord-298525-hhcfrjrn 276 82 in in IN cord-298525-hhcfrjrn 276 83 man man NN cord-298525-hhcfrjrn 276 84 Alterations Alterations NNPS cord-298525-hhcfrjrn 276 85 in in IN cord-298525-hhcfrjrn 276 86 autonomic autonomic JJ cord-298525-hhcfrjrn 276 87 function function NN cord-298525-hhcfrjrn 276 88 in in IN cord-298525-hhcfrjrn 276 89 the the DT cord-298525-hhcfrjrn 276 90 guinea guinea NN cord-298525-hhcfrjrn 276 91 pig pig NN cord-298525-hhcfrjrn 276 92 eye eye NN cord-298525-hhcfrjrn 276 93 following follow VBG cord-298525-hhcfrjrn 276 94 exposure exposure NN cord-298525-hhcfrjrn 276 95 to to IN cord-298525-hhcfrjrn 276 96 dichlorvos dichlorvos NNP cord-298525-hhcfrjrn 276 97 vapor vapor NN cord-298525-hhcfrjrn 276 98 Evaluation Evaluation NNP cord-298525-hhcfrjrn 276 99 of of IN cord-298525-hhcfrjrn 276 100 miosis miosis NN cord-298525-hhcfrjrn 276 101 , , , cord-298525-hhcfrjrn 276 102 behavior behavior NN cord-298525-hhcfrjrn 276 103 and and CC cord-298525-hhcfrjrn 276 104 cholinesterase cholinesterase NN cord-298525-hhcfrjrn 276 105 inhibition inhibition NN cord-298525-hhcfrjrn 276 106 from from IN cord-298525-hhcfrjrn 276 107 low low JJ cord-298525-hhcfrjrn 276 108 - - HYPH cord-298525-hhcfrjrn 276 109 level level NN cord-298525-hhcfrjrn 276 110 , , , cord-298525-hhcfrjrn 276 111 whole whole JJ cord-298525-hhcfrjrn 276 112 - - HYPH cord-298525-hhcfrjrn 276 113 body body NN cord-298525-hhcfrjrn 276 114 vapor vapor NN cord-298525-hhcfrjrn 276 115 exposure exposure NN cord-298525-hhcfrjrn 276 116 to to IN cord-298525-hhcfrjrn 276 117 soman soman NNP cord-298525-hhcfrjrn 276 118 in in IN cord-298525-hhcfrjrn 276 119 African african JJ cord-298525-hhcfrjrn 276 120 green green JJ cord-298525-hhcfrjrn 276 121 monkeys monkey NNS cord-298525-hhcfrjrn 276 122 ( ( -LRB- cord-298525-hhcfrjrn 276 123 Chlorocebus Chlorocebus NNP cord-298525-hhcfrjrn 276 124 sabeus sabeus NNP cord-298525-hhcfrjrn 276 125 ) ) -RRB- cord-298525-hhcfrjrn 276 126 Relationship relationship NN cord-298525-hhcfrjrn 276 127 between between IN cord-298525-hhcfrjrn 276 128 pupil pupil NN cord-298525-hhcfrjrn 276 129 size size NN cord-298525-hhcfrjrn 276 130 and and CC cord-298525-hhcfrjrn 276 131 acetylcholinesterase acetylcholinesterase NN cord-298525-hhcfrjrn 276 132 activity activity NN cord-298525-hhcfrjrn 276 133 in in IN cord-298525-hhcfrjrn 276 134 patients patient NNS cord-298525-hhcfrjrn 276 135 exposed expose VBN cord-298525-hhcfrjrn 276 136 to to IN cord-298525-hhcfrjrn 276 137 sarin sarin NN cord-298525-hhcfrjrn 276 138 vapor vapor NN cord-298525-hhcfrjrn 276 139 Comparison comparison NN cord-298525-hhcfrjrn 276 140 of of IN cord-298525-hhcfrjrn 276 141 low low JJ cord-298525-hhcfrjrn 276 142 - - HYPH cord-298525-hhcfrjrn 276 143 level level NN cord-298525-hhcfrjrn 276 144 sarin sarin NNS cord-298525-hhcfrjrn 276 145 and and CC cord-298525-hhcfrjrn 276 146 cyclosarin cyclosarin NNP cord-298525-hhcfrjrn 276 147 vapor vapor NN cord-298525-hhcfrjrn 276 148 exposure exposure NN cord-298525-hhcfrjrn 276 149 on on IN cord-298525-hhcfrjrn 276 150 pupil pupil NN cord-298525-hhcfrjrn 276 151 size size NN cord-298525-hhcfrjrn 276 152 of of IN cord-298525-hhcfrjrn 276 153 the the DT cord-298525-hhcfrjrn 276 154 Gottingen Gottingen NNP cord-298525-hhcfrjrn 276 155 minipig minipig NNP cord-298525-hhcfrjrn 276 156 : : : cord-298525-hhcfrjrn 276 157 Effects effect NNS cord-298525-hhcfrjrn 276 158 of of IN cord-298525-hhcfrjrn 276 159 exposure exposure NN cord-298525-hhcfrjrn 276 160 concentration concentration NN cord-298525-hhcfrjrn 276 161 and and CC cord-298525-hhcfrjrn 276 162 duration duration NN cord-298525-hhcfrjrn 276 163 Gender gender NN cord-298525-hhcfrjrn 276 164 difference difference NN cord-298525-hhcfrjrn 276 165 in in IN cord-298525-hhcfrjrn 276 166 the the DT cord-298525-hhcfrjrn 276 167 miotic miotic JJ cord-298525-hhcfrjrn 276 168 potency potency NN cord-298525-hhcfrjrn 276 169 of of IN cord-298525-hhcfrjrn 276 170 soman soman NNP cord-298525-hhcfrjrn 276 171 vapor vapor NN cord-298525-hhcfrjrn 276 172 in in IN cord-298525-hhcfrjrn 276 173 rats rat NNS cord-298525-hhcfrjrn 276 174 Fenthion Fenthion NNP cord-298525-hhcfrjrn 276 175 produces produce VBZ cord-298525-hhcfrjrn 276 176 a a DT cord-298525-hhcfrjrn 276 177 persistent persistent JJ cord-298525-hhcfrjrn 276 178 decrease decrease NN cord-298525-hhcfrjrn 276 179 in in IN cord-298525-hhcfrjrn 276 180 muscarinic muscarinic JJ cord-298525-hhcfrjrn 276 181 receptor receptor NN cord-298525-hhcfrjrn 276 182 function function NN cord-298525-hhcfrjrn 276 183 in in IN cord-298525-hhcfrjrn 276 184 the the DT cord-298525-hhcfrjrn 276 185 adult adult NN cord-298525-hhcfrjrn 276 186 rat rat NN cord-298525-hhcfrjrn 276 187 retina retina NN cord-298525-hhcfrjrn 276 188 Muscarinic Muscarinic NNP cord-298525-hhcfrjrn 276 189 receptor receptor NN cord-298525-hhcfrjrn 276 190 dysfunction dysfunction NN cord-298525-hhcfrjrn 276 191 induced induce VBN cord-298525-hhcfrjrn 276 192 by by IN cord-298525-hhcfrjrn 276 193 exposure exposure NN cord-298525-hhcfrjrn 276 194 to to IN cord-298525-hhcfrjrn 276 195 low low JJ cord-298525-hhcfrjrn 276 196 levels level NNS cord-298525-hhcfrjrn 276 197 of of IN cord-298525-hhcfrjrn 276 198 soman soman NN cord-298525-hhcfrjrn 276 199 vapor vapor NN cord-298525-hhcfrjrn 276 200 Efficacy Efficacy NNP cord-298525-hhcfrjrn 276 201 assessment assessment NN cord-298525-hhcfrjrn 276 202 of of IN cord-298525-hhcfrjrn 276 203 a a DT cord-298525-hhcfrjrn 276 204 combined combine VBN cord-298525-hhcfrjrn 276 205 anticholinergic anticholinergic NN cord-298525-hhcfrjrn 276 206 and and CC cord-298525-hhcfrjrn 276 207 oxime oxime NN cord-298525-hhcfrjrn 276 208 treatment treatment NN cord-298525-hhcfrjrn 276 209 against against IN cord-298525-hhcfrjrn 276 210 topical topical JJ cord-298525-hhcfrjrn 276 211 sarin sarin NNS cord-298525-hhcfrjrn 276 212 - - HYPH cord-298525-hhcfrjrn 276 213 induced induce VBN cord-298525-hhcfrjrn 276 214 miosis miosis NN cord-298525-hhcfrjrn 276 215 and and CC cord-298525-hhcfrjrn 276 216 visual visual JJ cord-298525-hhcfrjrn 276 217 impairment impairment NN cord-298525-hhcfrjrn 276 218 in in IN cord-298525-hhcfrjrn 276 219 rats rat NNS cord-298525-hhcfrjrn 276 220 Clinical Clinical NNP cord-298525-hhcfrjrn 276 221 Toxicology Toxicology NNP cord-298525-hhcfrjrn 276 222 of of IN cord-298525-hhcfrjrn 276 223 Anticholinesterase Anticholinesterase NNP cord-298525-hhcfrjrn 276 224 Agents agent NNS cord-298525-hhcfrjrn 276 225 in in IN cord-298525-hhcfrjrn 276 226 Humans human NNS cord-298525-hhcfrjrn 277 1 A a DT cord-298525-hhcfrjrn 277 2 pupillographical pupillographical JJ cord-298525-hhcfrjrn 277 3 study study NN cord-298525-hhcfrjrn 277 4 on on IN cord-298525-hhcfrjrn 277 5 the the DT cord-298525-hhcfrjrn 277 6 presence presence NN cord-298525-hhcfrjrn 277 7 of of IN cord-298525-hhcfrjrn 277 8 organochlorine organochlorine NN cord-298525-hhcfrjrn 277 9 pesticides pesticide NNS cord-298525-hhcfrjrn 277 10 in in IN cord-298525-hhcfrjrn 277 11 autonomic autonomic JJ cord-298525-hhcfrjrn 277 12 nerve nerve NN cord-298525-hhcfrjrn 277 13 disturbance disturbance NN cord-298525-hhcfrjrn 278 1 The the DT cord-298525-hhcfrjrn 278 2 cholinergic cholinergic JJ cord-298525-hhcfrjrn 278 3 anti anti JJ cord-298525-hhcfrjrn 278 4 - - JJ cord-298525-hhcfrjrn 278 5 inflammatory inflammatory JJ cord-298525-hhcfrjrn 278 6 pathway pathway NN cord-298525-hhcfrjrn 278 7 : : : cord-298525-hhcfrjrn 279 1 A a DT cord-298525-hhcfrjrn 279 2 missing missing JJ cord-298525-hhcfrjrn 279 3 link link NN cord-298525-hhcfrjrn 279 4 in in IN cord-298525-hhcfrjrn 279 5 neuroimmunomodulation neuroimmunomodulation NN cord-298525-hhcfrjrn 280 1 The the DT cord-298525-hhcfrjrn 280 2 inflammatory inflammatory JJ cord-298525-hhcfrjrn 280 3 reflex reflex NN cord-298525-hhcfrjrn 280 4 Neural neural JJ cord-298525-hhcfrjrn 280 5 regulation regulation NN cord-298525-hhcfrjrn 280 6 of of IN cord-298525-hhcfrjrn 280 7 innate innate JJ cord-298525-hhcfrjrn 280 8 immunity immunity NN cord-298525-hhcfrjrn 280 9 : : : cord-298525-hhcfrjrn 280 10 A a DT cord-298525-hhcfrjrn 280 11 coordinated coordinated JJ cord-298525-hhcfrjrn 280 12 nonspecific nonspecific JJ cord-298525-hhcfrjrn 280 13 host host NN cord-298525-hhcfrjrn 280 14 response response NN cord-298525-hhcfrjrn 280 15 to to IN cord-298525-hhcfrjrn 280 16 pathogens pathogen NNS cord-298525-hhcfrjrn 280 17 Vagal vagal JJ cord-298525-hhcfrjrn 280 18 immune immune NN cord-298525-hhcfrjrn 280 19 - - HYPH cord-298525-hhcfrjrn 280 20 to to IN cord-298525-hhcfrjrn 280 21 - - HYPH cord-298525-hhcfrjrn 280 22 brain brain NN cord-298525-hhcfrjrn 280 23 communication communication NN cord-298525-hhcfrjrn 280 24 : : : cord-298525-hhcfrjrn 280 25 A a DT cord-298525-hhcfrjrn 280 26 visceral visceral JJ cord-298525-hhcfrjrn 280 27 chemosensory chemosensory NN cord-298525-hhcfrjrn 280 28 pathway pathway NN cord-298525-hhcfrjrn 280 29 Pathogenic pathogenic JJ cord-298525-hhcfrjrn 280 30 human human JJ cord-298525-hhcfrjrn 280 31 coronavirus coronavirus NN cord-298525-hhcfrjrn 280 32 infections infection NNS cord-298525-hhcfrjrn 280 33 : : : cord-298525-hhcfrjrn 280 34 Causes cause NNS cord-298525-hhcfrjrn 280 35 and and CC cord-298525-hhcfrjrn 280 36 consequences consequence NNS cord-298525-hhcfrjrn 280 37 of of IN cord-298525-hhcfrjrn 280 38 cytokine cytokine NN cord-298525-hhcfrjrn 280 39 storm storm NN cord-298525-hhcfrjrn 280 40 and and CC cord-298525-hhcfrjrn 280 41 immunopathology immunopathology NN cord-298525-hhcfrjrn 281 1 An an DT cord-298525-hhcfrjrn 281 2 interferon interferon NN cord-298525-hhcfrjrn 281 3 - - HYPH cord-298525-hhcfrjrn 281 4 gamma gamma NN cord-298525-hhcfrjrn 281 5 - - HYPH cord-298525-hhcfrjrn 281 6 related relate VBN cord-298525-hhcfrjrn 281 7 cytokine cytokine NN cord-298525-hhcfrjrn 281 8 storm storm NN cord-298525-hhcfrjrn 281 9 in in IN cord-298525-hhcfrjrn 281 10 SARS SARS NNP cord-298525-hhcfrjrn 281 11 patients patient NNS cord-298525-hhcfrjrn 281 12 Dynamics dynamic NNS cord-298525-hhcfrjrn 281 13 of of IN cord-298525-hhcfrjrn 281 14 a a DT cord-298525-hhcfrjrn 281 15 cytokine cytokine NN cord-298525-hhcfrjrn 281 16 storm storm NN cord-298525-hhcfrjrn 282 1 The the DT cord-298525-hhcfrjrn 282 2 cytokine cytokine NN cord-298525-hhcfrjrn 282 3 storm storm NN cord-298525-hhcfrjrn 282 4 of of IN cord-298525-hhcfrjrn 282 5 severe severe JJ cord-298525-hhcfrjrn 282 6 influenza influenza NN cord-298525-hhcfrjrn 282 7 and and CC cord-298525-hhcfrjrn 282 8 development development NN cord-298525-hhcfrjrn 282 9 of of IN cord-298525-hhcfrjrn 282 10 immunomodulatory immunomodulatory JJ cord-298525-hhcfrjrn 282 11 therapy therapy NN cord-298525-hhcfrjrn 282 12 How how WRB cord-298525-hhcfrjrn 282 13 Ebola Ebola NNP cord-298525-hhcfrjrn 282 14 and and CC cord-298525-hhcfrjrn 282 15 Marburg Marburg NNP cord-298525-hhcfrjrn 282 16 viruses virus NNS cord-298525-hhcfrjrn 282 17 battle battle VBP cord-298525-hhcfrjrn 282 18 the the DT cord-298525-hhcfrjrn 282 19 immune immune JJ cord-298525-hhcfrjrn 282 20 system system NN cord-298525-hhcfrjrn 283 1 Interleukin interleukin NN cord-298525-hhcfrjrn 283 2 10 10 CD cord-298525-hhcfrjrn 283 3 inhibits inhibit VBZ cord-298525-hhcfrjrn 283 4 pro pro JJ cord-298525-hhcfrjrn 283 5 - - JJ cord-298525-hhcfrjrn 283 6 inflammatory inflammatory JJ cord-298525-hhcfrjrn 283 7 cytokine cytokine NN cord-298525-hhcfrjrn 283 8 responses response NNS cord-298525-hhcfrjrn 283 9 and and CC cord-298525-hhcfrjrn 283 10 killing killing NN cord-298525-hhcfrjrn 283 11 of of IN cord-298525-hhcfrjrn 283 12 Burkholderia Burkholderia NNP cord-298525-hhcfrjrn 283 13 pseudomallei pseudomallei NN cord-298525-hhcfrjrn 283 14 Early early JJ cord-298525-hhcfrjrn 283 15 host host NN cord-298525-hhcfrjrn 283 16 cell cell NN cord-298525-hhcfrjrn 283 17 targets target NNS cord-298525-hhcfrjrn 283 18 of of IN cord-298525-hhcfrjrn 283 19 Yersinia Yersinia NNP cord-298525-hhcfrjrn 283 20 pestis pestis NN cord-298525-hhcfrjrn 283 21 during during IN cord-298525-hhcfrjrn 283 22 primary primary JJ cord-298525-hhcfrjrn 283 23 pneumonic pneumonic NN cord-298525-hhcfrjrn 283 24 plague plague NN cord-298525-hhcfrjrn 283 25 Functional Functional NNP cord-298525-hhcfrjrn 283 26 neuroanatomy neuroanatomy NN cord-298525-hhcfrjrn 283 27 of of IN cord-298525-hhcfrjrn 283 28 the the DT cord-298525-hhcfrjrn 283 29 noradrenergic noradrenergic JJ cord-298525-hhcfrjrn 283 30 locus locus NN cord-298525-hhcfrjrn 283 31 coeruleus coeruleu VBZ cord-298525-hhcfrjrn 283 32 : : : cord-298525-hhcfrjrn 284 1 Its -PRON- PRP$ cord-298525-hhcfrjrn 284 2 roles role NNS cord-298525-hhcfrjrn 284 3 in in IN cord-298525-hhcfrjrn 284 4 the the DT cord-298525-hhcfrjrn 284 5 regulation regulation NN cord-298525-hhcfrjrn 284 6 of of IN cord-298525-hhcfrjrn 284 7 arousal arousal NN cord-298525-hhcfrjrn 284 8 and and CC cord-298525-hhcfrjrn 284 9 autonomic autonomic JJ cord-298525-hhcfrjrn 284 10 function function NN cord-298525-hhcfrjrn 284 11 part part NN cord-298525-hhcfrjrn 284 12 II II NNP cord-298525-hhcfrjrn 284 13 : : : cord-298525-hhcfrjrn 284 14 Physiological physiological JJ cord-298525-hhcfrjrn 284 15 and and CC cord-298525-hhcfrjrn 284 16 pharmacological pharmacological JJ cord-298525-hhcfrjrn 284 17 manipulations manipulation NNS cord-298525-hhcfrjrn 284 18 and and CC cord-298525-hhcfrjrn 284 19 pathological pathological JJ cord-298525-hhcfrjrn 284 20 alterations alteration NNS cord-298525-hhcfrjrn 284 21 of of IN cord-298525-hhcfrjrn 284 22 locus locus NN cord-298525-hhcfrjrn 284 23 coeruleus coeruleu VBZ cord-298525-hhcfrjrn 284 24 activity activity NN cord-298525-hhcfrjrn 284 25 in in IN cord-298525-hhcfrjrn 284 26 humans human NNS cord-298525-hhcfrjrn 284 27 Modulation modulation NN cord-298525-hhcfrjrn 284 28 of of IN cord-298525-hhcfrjrn 284 29 physiological physiological JJ cord-298525-hhcfrjrn 284 30 reflexes reflex NNS cord-298525-hhcfrjrn 284 31 by by IN cord-298525-hhcfrjrn 284 32 pain pain NN cord-298525-hhcfrjrn 284 33 : : : cord-298525-hhcfrjrn 284 34 Role role NN cord-298525-hhcfrjrn 284 35 of of IN cord-298525-hhcfrjrn 284 36 the the DT cord-298525-hhcfrjrn 284 37 locus locus NN cord-298525-hhcfrjrn 284 38 coeruleus coeruleu VBZ cord-298525-hhcfrjrn 285 1 The the DT cord-298525-hhcfrjrn 285 2 protective protective JJ cord-298525-hhcfrjrn 285 3 effect effect NN cord-298525-hhcfrjrn 285 4 of of IN cord-298525-hhcfrjrn 285 5 the the DT cord-298525-hhcfrjrn 285 6 cholinergic cholinergic JJ cord-298525-hhcfrjrn 285 7 anti anti JJ cord-298525-hhcfrjrn 285 8 - - JJ cord-298525-hhcfrjrn 285 9 inflammatory inflammatory JJ cord-298525-hhcfrjrn 285 10 pathway pathway NN cord-298525-hhcfrjrn 285 11 against against IN cord-298525-hhcfrjrn 285 12 septic septic JJ cord-298525-hhcfrjrn 285 13 shock shock NN cord-298525-hhcfrjrn 285 14 in in IN cord-298525-hhcfrjrn 285 15 rats rat NNS cord-298525-hhcfrjrn 286 1 The the DT cord-298525-hhcfrjrn 286 2 cholinergic cholinergic JJ cord-298525-hhcfrjrn 286 3 anti anti JJ cord-298525-hhcfrjrn 286 4 - - JJ cord-298525-hhcfrjrn 286 5 inflammatory inflammatory JJ cord-298525-hhcfrjrn 286 6 pathway pathway NN cord-298525-hhcfrjrn 286 7 regulates regulate VBZ cord-298525-hhcfrjrn 286 8 the the DT cord-298525-hhcfrjrn 286 9 host host NN cord-298525-hhcfrjrn 286 10 response response NN cord-298525-hhcfrjrn 286 11 during during IN cord-298525-hhcfrjrn 286 12 septic septic JJ cord-298525-hhcfrjrn 286 13 peritonitis peritonitis NN cord-298525-hhcfrjrn 286 14 Cholinergic cholinergic JJ cord-298525-hhcfrjrn 286 15 agonists agonist NNS cord-298525-hhcfrjrn 287 1 inhibit inhibit VB cord-298525-hhcfrjrn 287 2 HMGB1 HMGB1 NNP cord-298525-hhcfrjrn 287 3 release release NN cord-298525-hhcfrjrn 287 4 and and CC cord-298525-hhcfrjrn 287 5 improve improve VB cord-298525-hhcfrjrn 287 6 survival survival NN cord-298525-hhcfrjrn 287 7 in in IN cord-298525-hhcfrjrn 287 8 experimental experimental JJ cord-298525-hhcfrjrn 287 9 sepsis sepsis NN cord-298525-hhcfrjrn 287 10 Stimulation stimulation NN cord-298525-hhcfrjrn 287 11 of of IN cord-298525-hhcfrjrn 287 12 acetylcholine acetylcholine NN cord-298525-hhcfrjrn 287 13 receptors receptor NNS cord-298525-hhcfrjrn 287 14 impairs impair VBZ cord-298525-hhcfrjrn 287 15 host host NN cord-298525-hhcfrjrn 287 16 defence defence NN cord-298525-hhcfrjrn 287 17 during during IN cord-298525-hhcfrjrn 288 1 pneumococcal pneumococcal JJ cord-298525-hhcfrjrn 288 2 pneumonia pneumonia NN cord-298525-hhcfrjrn 288 3 Brain Brain NNP cord-298525-hhcfrjrn 288 4 acetylcholinesterase acetylcholinesterase NN cord-298525-hhcfrjrn 288 5 activity activity NN cord-298525-hhcfrjrn 288 6 controls control VBZ cord-298525-hhcfrjrn 288 7 systemic systemic JJ cord-298525-hhcfrjrn 288 8 cytokine cytokine NN cord-298525-hhcfrjrn 288 9 levels level NNS cord-298525-hhcfrjrn 288 10 through through IN cord-298525-hhcfrjrn 288 11 the the DT cord-298525-hhcfrjrn 288 12 cholinergic cholinergic JJ cord-298525-hhcfrjrn 288 13 anti anti JJ cord-298525-hhcfrjrn 288 14 - - JJ cord-298525-hhcfrjrn 288 15 inflammatory inflammatory JJ cord-298525-hhcfrjrn 288 16 pathway pathway NN cord-298525-hhcfrjrn 288 17 Controlling control VBG cord-298525-hhcfrjrn 288 18 inflammation inflammation NN cord-298525-hhcfrjrn 288 19 : : : cord-298525-hhcfrjrn 289 1 The the DT cord-298525-hhcfrjrn 289 2 cholinergic cholinergic JJ cord-298525-hhcfrjrn 289 3 anti anti JJ cord-298525-hhcfrjrn 289 4 - - JJ cord-298525-hhcfrjrn 289 5 inflammatory inflammatory JJ cord-298525-hhcfrjrn 289 6 pathway pathway NN cord-298525-hhcfrjrn 289 7 Xanomeline Xanomeline NNP cord-298525-hhcfrjrn 289 8 suppresses suppress VBZ cord-298525-hhcfrjrn 289 9 excessive excessive JJ cord-298525-hhcfrjrn 289 10 pro pro JJ cord-298525-hhcfrjrn 289 11 - - JJ cord-298525-hhcfrjrn 289 12 inflammatory inflammatory JJ cord-298525-hhcfrjrn 289 13 cytokine cytokine NN cord-298525-hhcfrjrn 289 14 responses response NNS cord-298525-hhcfrjrn 289 15 through through IN cord-298525-hhcfrjrn 289 16 neural neural JJ cord-298525-hhcfrjrn 289 17 signal signal NN cord-298525-hhcfrjrn 289 18 - - HYPH cord-298525-hhcfrjrn 289 19 mediated mediate VBN cord-298525-hhcfrjrn 289 20 pathways pathway NNS cord-298525-hhcfrjrn 289 21 and and CC cord-298525-hhcfrjrn 289 22 improves improve VBZ cord-298525-hhcfrjrn 289 23 survival survival NN cord-298525-hhcfrjrn 289 24 in in IN cord-298525-hhcfrjrn 289 25 lethal lethal JJ cord-298525-hhcfrjrn 289 26 inflammation inflammation NN cord-298525-hhcfrjrn 289 27 Cholinesterases cholinesterase NNS cord-298525-hhcfrjrn 289 28 as as IN cord-298525-hhcfrjrn 289 29 markers marker NNS cord-298525-hhcfrjrn 289 30 of of IN cord-298525-hhcfrjrn 289 31 the the DT cord-298525-hhcfrjrn 289 32 inflammatory inflammatory JJ cord-298525-hhcfrjrn 289 33 process process NN cord-298525-hhcfrjrn 289 34 in in IN cord-298525-hhcfrjrn 289 35 rats rat NNS cord-298525-hhcfrjrn 289 36 infected infect VBN cord-298525-hhcfrjrn 289 37 with with IN cord-298525-hhcfrjrn 289 38 Leptospira Leptospira NNP cord-298525-hhcfrjrn 289 39 interrogans interrogan NNS cord-298525-hhcfrjrn 289 40 serovar serovar NN cord-298525-hhcfrjrn 289 41 Icterohaemorrhagiae Icterohaemorrhagiae NNP cord-298525-hhcfrjrn 289 42 Influence influence NN cord-298525-hhcfrjrn 289 43 of of IN cord-298525-hhcfrjrn 289 44 respiratory respiratory JJ cord-298525-hhcfrjrn 289 45 tract tract NN cord-298525-hhcfrjrn 289 46 viral viral JJ cord-298525-hhcfrjrn 289 47 infection infection NN cord-298525-hhcfrjrn 289 48 on on IN cord-298525-hhcfrjrn 289 49 endothelin-1-induced endothelin-1-induced JJ cord-298525-hhcfrjrn 289 50 potentiation potentiation NN cord-298525-hhcfrjrn 289 51 of of IN cord-298525-hhcfrjrn 289 52 cholinergic cholinergic JJ cord-298525-hhcfrjrn 289 53 nerve nerve NN cord-298525-hhcfrjrn 289 54 - - HYPH cord-298525-hhcfrjrn 289 55 mediated mediate VBN cord-298525-hhcfrjrn 289 56 contraction contraction NN cord-298525-hhcfrjrn 289 57 in in IN cord-298525-hhcfrjrn 289 58 mouse mouse NN cord-298525-hhcfrjrn 289 59 trachea trachea NN cord-298525-hhcfrjrn 289 60 Avian avian JJ cord-298525-hhcfrjrn 289 61 influenza influenza NN cord-298525-hhcfrjrn 289 62 H5N1 H5N1 NNP cord-298525-hhcfrjrn 289 63 virus virus NN cord-298525-hhcfrjrn 290 1 induces induce VBZ cord-298525-hhcfrjrn 290 2 cytopathy cytopathy NNP cord-298525-hhcfrjrn 290 3 and and CC cord-298525-hhcfrjrn 290 4 proinflammatory proinflammatory JJ cord-298525-hhcfrjrn 290 5 cytokine cytokine NN cord-298525-hhcfrjrn 290 6 responses response NNS cord-298525-hhcfrjrn 290 7 in in IN cord-298525-hhcfrjrn 290 8 human human JJ cord-298525-hhcfrjrn 290 9 astrocytic astrocytic JJ cord-298525-hhcfrjrn 290 10 and and CC cord-298525-hhcfrjrn 290 11 neuronal neuronal JJ cord-298525-hhcfrjrn 290 12 cell cell NN cord-298525-hhcfrjrn 290 13 lines line NNS cord-298525-hhcfrjrn 290 14 Pupillary Pupillary NNP cord-298525-hhcfrjrn 290 15 responses response NNS cord-298525-hhcfrjrn 290 16 to to IN cord-298525-hhcfrjrn 290 17 stimulus stimulus NN cord-298525-hhcfrjrn 290 18 structure structure NN cord-298525-hhcfrjrn 290 19 , , , cord-298525-hhcfrjrn 290 20 colour colour NN cord-298525-hhcfrjrn 290 21 and and CC cord-298525-hhcfrjrn 290 22 movement movement NN cord-298525-hhcfrjrn 291 1 Weak weak JJ cord-298525-hhcfrjrn 291 2 gender gender NN cord-298525-hhcfrjrn 291 3 effects effect NNS cord-298525-hhcfrjrn 291 4 on on IN cord-298525-hhcfrjrn 291 5 transient transient JJ cord-298525-hhcfrjrn 291 6 pupillary pupillary JJ cord-298525-hhcfrjrn 291 7 light light JJ cord-298525-hhcfrjrn 291 8 reflex reflex NN cord-298525-hhcfrjrn 291 9 Effect effect NN cord-298525-hhcfrjrn 291 10 of of IN cord-298525-hhcfrjrn 291 11 age age NN cord-298525-hhcfrjrn 291 12 on on IN cord-298525-hhcfrjrn 291 13 pupillary pupillary JJ cord-298525-hhcfrjrn 291 14 light light JJ cord-298525-hhcfrjrn 291 15 reflex reflex NN cord-298525-hhcfrjrn 291 16 : : : cord-298525-hhcfrjrn 291 17 Evaluation evaluation NN cord-298525-hhcfrjrn 291 18 of of IN cord-298525-hhcfrjrn 291 19 pupil pupil NN cord-298525-hhcfrjrn 291 20 mobility mobility NN cord-298525-hhcfrjrn 291 21 for for IN cord-298525-hhcfrjrn 291 22 clinical clinical JJ cord-298525-hhcfrjrn 291 23 practice practice NN cord-298525-hhcfrjrn 291 24 and and CC cord-298525-hhcfrjrn 291 25 research research VB cord-298525-hhcfrjrn 291 26 The the DT cord-298525-hhcfrjrn 291 27 pupillary pupillary JJ cord-298525-hhcfrjrn 291 28 light light JJ cord-298525-hhcfrjrn 291 29 reflex reflex NN cord-298525-hhcfrjrn 291 30 . . . cord-298525-hhcfrjrn 292 1 1 1 LS cord-298525-hhcfrjrn 292 2 . . . cord-298525-hhcfrjrn 293 1 Age age NN cord-298525-hhcfrjrn 293 2 - - HYPH cord-298525-hhcfrjrn 293 3 dependent dependent JJ cord-298525-hhcfrjrn 293 4 and and CC cord-298525-hhcfrjrn 293 5 age age NN cord-298525-hhcfrjrn 293 6 - - HYPH cord-298525-hhcfrjrn 293 7 independent independent JJ cord-298525-hhcfrjrn 293 8 parameters parameter NNS cord-298525-hhcfrjrn 293 9 in in IN cord-298525-hhcfrjrn 293 10 normal normal JJ cord-298525-hhcfrjrn 293 11 subjects subject NNS cord-298525-hhcfrjrn 294 1 The the DT cord-298525-hhcfrjrn 294 2 influence influence NN cord-298525-hhcfrjrn 294 3 of of IN cord-298525-hhcfrjrn 294 4 iris iris NN cord-298525-hhcfrjrn 294 5 color color NN cord-298525-hhcfrjrn 294 6 on on IN cord-298525-hhcfrjrn 294 7 the the DT cord-298525-hhcfrjrn 294 8 pupillary pupillary JJ cord-298525-hhcfrjrn 294 9 light light JJ cord-298525-hhcfrjrn 294 10 reflex reflex NN cord-298525-hhcfrjrn 294 11 Visual visual JJ cord-298525-hhcfrjrn 294 12 acuity acuity NN cord-298525-hhcfrjrn 294 13 measured measure VBN cord-298525-hhcfrjrn 294 14 with with IN cord-298525-hhcfrjrn 294 15 pupil pupil NN cord-298525-hhcfrjrn 294 16 responses response NNS cord-298525-hhcfrjrn 294 17 to to IN cord-298525-hhcfrjrn 294 18 checkerboard checkerboard VB cord-298525-hhcfrjrn 294 19 stimuli stimulus NNS cord-298525-hhcfrjrn 294 20 Spatial spatial JJ cord-298525-hhcfrjrn 294 21 pattern pattern NN cord-298525-hhcfrjrn 294 22 as as IN cord-298525-hhcfrjrn 294 23 a a DT cord-298525-hhcfrjrn 294 24 stimulus stimulus NN cord-298525-hhcfrjrn 294 25 to to IN cord-298525-hhcfrjrn 294 26 the the DT cord-298525-hhcfrjrn 294 27 pupillary pupillary JJ cord-298525-hhcfrjrn 294 28 system system NN cord-298525-hhcfrjrn 294 29 Task Task NNP cord-298525-hhcfrjrn 294 30 - - HYPH cord-298525-hhcfrjrn 294 31 evoked evoke VBN cord-298525-hhcfrjrn 294 32 pupillary pupillary JJ cord-298525-hhcfrjrn 294 33 responses response NNS cord-298525-hhcfrjrn 294 34 , , , cord-298525-hhcfrjrn 294 35 processing processing NN cord-298525-hhcfrjrn 294 36 load load NN cord-298525-hhcfrjrn 294 37 , , , cord-298525-hhcfrjrn 294 38 and and CC cord-298525-hhcfrjrn 294 39 the the DT cord-298525-hhcfrjrn 294 40 structure structure NN cord-298525-hhcfrjrn 294 41 of of IN cord-298525-hhcfrjrn 294 42 processing processing NN cord-298525-hhcfrjrn 294 43 resources resource NNS cord-298525-hhcfrjrn 294 44 Iris Iris NNP cord-298525-hhcfrjrn 294 45 mechanics mechanic NNS cord-298525-hhcfrjrn 294 46 . . . cord-298525-hhcfrjrn 295 1 II II NNP cord-298525-hhcfrjrn 295 2 . . . cord-298525-hhcfrjrn 296 1 Influence influence NN cord-298525-hhcfrjrn 296 2 of of IN cord-298525-hhcfrjrn 296 3 pupil pupil NN cord-298525-hhcfrjrn 296 4 size size NN cord-298525-hhcfrjrn 296 5 on on IN cord-298525-hhcfrjrn 296 6 details detail NNS cord-298525-hhcfrjrn 296 7 of of IN cord-298525-hhcfrjrn 296 8 iris iris NNP cord-298525-hhcfrjrn 296 9 structure structure NN cord-298525-hhcfrjrn 297 1 The the DT cord-298525-hhcfrjrn 297 2 authors author NNS cord-298525-hhcfrjrn 297 3 would would MD cord-298525-hhcfrjrn 297 4 like like VB cord-298525-hhcfrjrn 297 5 to to TO cord-298525-hhcfrjrn 297 6 thank thank VB cord-298525-hhcfrjrn 297 7 Philip Philip NNP cord-298525-hhcfrjrn 297 8 Lees Lees NNP cord-298525-hhcfrjrn 297 9 for for IN cord-298525-hhcfrjrn 297 10 his -PRON- PRP$ cord-298525-hhcfrjrn 297 11 assistance assistance NN cord-298525-hhcfrjrn 297 12 in in IN cord-298525-hhcfrjrn 297 13 finalizing finalize VBG cord-298525-hhcfrjrn 297 14 this this DT cord-298525-hhcfrjrn 297 15 manuscript manuscript NN cord-298525-hhcfrjrn 297 16 . . . cord-298525-hhcfrjrn 298 1 The the DT cord-298525-hhcfrjrn 298 2 authors author NNS cord-298525-hhcfrjrn 298 3 declare declare VBP cord-298525-hhcfrjrn 298 4 no no DT cord-298525-hhcfrjrn 298 5 conflict conflict NN cord-298525-hhcfrjrn 298 6 of of IN cord-298525-hhcfrjrn 298 7 interest interest NN cord-298525-hhcfrjrn 298 8 . . .