id	sid	tid	token	lemma	pos
cord-288868-qfdxri93	1	1	key	key	JJ
cord-288868-qfdxri93	1	2	:	:	:
cord-288868-qfdxri93	1	3	cord-288868-qfdxri93	cord-288868-qfdxri93	ADD
cord-288868-qfdxri93	2	1	authors	author	NNS
cord-288868-qfdxri93	2	2	:	:	:
cord-288868-qfdxri93	2	3	Wack	wack	UH
cord-288868-qfdxri93	2	4	,	,	,
cord-288868-qfdxri93	2	5	Andreas	Andreas	NNP
cord-288868-qfdxri93	2	6	;	;	:
cord-288868-qfdxri93	2	7	Rappuoli	Rappuoli	NNP
cord-288868-qfdxri93	2	8	,	,	,
cord-288868-qfdxri93	2	9	Rino	Rino	NNP
cord-288868-qfdxri93	2	10	title	title	NN
cord-288868-qfdxri93	2	11	:	:	:
cord-288868-qfdxri93	2	12	Vaccinology	vaccinology	NN
cord-288868-qfdxri93	2	13	at	at	IN
cord-288868-qfdxri93	2	14	the	the	DT
cord-288868-qfdxri93	2	15	beginning	beginning	NN
cord-288868-qfdxri93	2	16	of	of	IN
cord-288868-qfdxri93	2	17	the	the	DT
cord-288868-qfdxri93	2	18	21st	21st	JJ
cord-288868-qfdxri93	2	19	century	century	NN
cord-288868-qfdxri93	2	20	date	date	NN
cord-288868-qfdxri93	2	21	:	:	:
cord-288868-qfdxri93	2	22	2005	2005	CD
cord-288868-qfdxri93	2	23	-	-	HYPH
cord-288868-qfdxri93	2	24	06	06	CD
cord-288868-qfdxri93	2	25	-	-	SYM
cord-288868-qfdxri93	2	26	13	13	CD
cord-288868-qfdxri93	2	27	journal	journal	NN
cord-288868-qfdxri93	2	28	:	:	:
cord-288868-qfdxri93	3	1	Curr	Curr	NNP
cord-288868-qfdxri93	3	2	Opin	Opin	NNP
cord-288868-qfdxri93	4	1	Immunol	Immunol	NNP
cord-288868-qfdxri93	4	2	DOI	DOI	NNP
cord-288868-qfdxri93	4	3	:	:	:
cord-288868-qfdxri93	4	4	10.1016	10.1016	CD
cord-288868-qfdxri93	4	5	/	/	SYM
cord-288868-qfdxri93	4	6	j.coi.2005.05.005	j.coi.2005.05.005	CD
cord-288868-qfdxri93	4	7	sha	sha	NNP
cord-288868-qfdxri93	4	8	:	:	:
cord-288868-qfdxri93	5	1	a22adb3d7ef0c66ada6270d213af060dbd790333	a22adb3d7ef0c66ada6270d213af060dbd790333	NNP
cord-288868-qfdxri93	5	2	doc_id	doc_id	NNP
cord-288868-qfdxri93	5	3	:	:	:
cord-288868-qfdxri93	5	4	288868	288868	CD
cord-288868-qfdxri93	5	5	cord_uid	cord_uid	NNS
cord-288868-qfdxri93	5	6	:	:	:
cord-288868-qfdxri93	6	1	qfdxri93	qfdxri93	NNP
cord-288868-qfdxri93	7	1	Today	today	NN
cord-288868-qfdxri93	7	2	,	,	,
cord-288868-qfdxri93	7	3	the	the	DT
cord-288868-qfdxri93	7	4	main	main	JJ
cord-288868-qfdxri93	7	5	challenges	challenge	NNS
cord-288868-qfdxri93	7	6	for	for	IN
cord-288868-qfdxri93	7	7	vaccinologists	vaccinologist	NNS
cord-288868-qfdxri93	7	8	include	include	VBP
cord-288868-qfdxri93	7	9	improving	improve	VBG
cord-288868-qfdxri93	7	10	vaccines	vaccine	NNS
cord-288868-qfdxri93	7	11	against	against	IN
cord-288868-qfdxri93	7	12	as	as	RB
cord-288868-qfdxri93	7	13	yet	yet	RB
cord-288868-qfdxri93	7	14	undefeated	undefeated	JJ
cord-288868-qfdxri93	7	15	pathogens	pathogen	NNS
cord-288868-qfdxri93	7	16	,	,	,
cord-288868-qfdxri93	7	17	rapid	rapid	JJ
cord-288868-qfdxri93	7	18	identification	identification	NN
cord-288868-qfdxri93	7	19	and	and	CC
cord-288868-qfdxri93	7	20	response	response	NN
cord-288868-qfdxri93	7	21	to	to	IN
cord-288868-qfdxri93	7	22	emerging	emerge	VBG
cord-288868-qfdxri93	7	23	diseases	disease	NNS
cord-288868-qfdxri93	7	24	and	and	CC
cord-288868-qfdxri93	7	25	successful	successful	JJ
cord-288868-qfdxri93	7	26	intervention	intervention	NN
cord-288868-qfdxri93	7	27	in	in	IN
cord-288868-qfdxri93	7	28	chronic	chronic	JJ
cord-288868-qfdxri93	7	29	diseases	disease	NNS
cord-288868-qfdxri93	7	30	in	in	IN
cord-288868-qfdxri93	7	31	which	which	WDT
cord-288868-qfdxri93	7	32	ongoing	ongoing	JJ
cord-288868-qfdxri93	7	33	immune	immune	JJ
cord-288868-qfdxri93	7	34	responses	response	NNS
cord-288868-qfdxri93	7	35	are	be	VBP
cord-288868-qfdxri93	7	36	insufficient	insufficient	JJ
cord-288868-qfdxri93	7	37	.	.	.
cord-288868-qfdxri93	8	1	Reverse	reverse	JJ
cord-288868-qfdxri93	8	2	genetics	genetic	NNS
cord-288868-qfdxri93	8	3	and	and	CC
cord-288868-qfdxri93	8	4	reverse	reverse	VB
cord-288868-qfdxri93	8	5	vaccinology	vaccinology	NN
cord-288868-qfdxri93	8	6	are	be	VBP
cord-288868-qfdxri93	8	7	now	now	RB
cord-288868-qfdxri93	8	8	used	use	VBN
cord-288868-qfdxri93	8	9	to	to	TO
cord-288868-qfdxri93	8	10	generate	generate	VB
cord-288868-qfdxri93	8	11	rapidly	rapidly	RB
cord-288868-qfdxri93	8	12	new	new	JJ
cord-288868-qfdxri93	8	13	vaccine	vaccine	NN
cord-288868-qfdxri93	8	14	strains	strain	NNS
cord-288868-qfdxri93	8	15	and	and	CC
cord-288868-qfdxri93	8	16	to	to	IN
cord-288868-qfdxri93	8	17	mine	mine	PRP$
cord-288868-qfdxri93	8	18	whole	whole	JJ
cord-288868-qfdxri93	8	19	genomes	genome	NNS
cord-288868-qfdxri93	8	20	in	in	IN
cord-288868-qfdxri93	8	21	the	the	DT
cord-288868-qfdxri93	8	22	search	search	NN
cord-288868-qfdxri93	8	23	for	for	IN
cord-288868-qfdxri93	8	24	promising	promising	JJ
cord-288868-qfdxri93	8	25	antigens	antigen	NNS
cord-288868-qfdxri93	8	26	.	.	.
cord-288868-qfdxri93	9	1	The	the	DT
cord-288868-qfdxri93	9	2	rational	rational	JJ
cord-288868-qfdxri93	9	3	design	design	NN
cord-288868-qfdxri93	9	4	of	of	IN
cord-288868-qfdxri93	9	5	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	9	6	has	have	VBZ
cord-288868-qfdxri93	9	7	become	become	VBN
cord-288868-qfdxri93	9	8	possible	possible	JJ
cord-288868-qfdxri93	9	9	as	as	IN
cord-288868-qfdxri93	9	10	a	a	DT
cord-288868-qfdxri93	9	11	result	result	NN
cord-288868-qfdxri93	9	12	of	of	IN
cord-288868-qfdxri93	9	13	the	the	DT
cord-288868-qfdxri93	9	14	discovery	discovery	NN
cord-288868-qfdxri93	9	15	of	of	IN
cord-288868-qfdxri93	9	16	the	the	DT
cord-288868-qfdxri93	9	17	receptors	receptor	NNS
cord-288868-qfdxri93	9	18	that	that	WDT
cord-288868-qfdxri93	9	19	recognize	recognize	VBP
cord-288868-qfdxri93	9	20	microbial	microbial	JJ
cord-288868-qfdxri93	9	21	patterns	pattern	NNS
cord-288868-qfdxri93	9	22	and	and	CC
cord-288868-qfdxri93	9	23	lead	lead	VBP
cord-288868-qfdxri93	9	24	to	to	IN
cord-288868-qfdxri93	9	25	dendritic	dendritic	JJ
cord-288868-qfdxri93	9	26	cell	cell	NN
cord-288868-qfdxri93	9	27	activation	activation	NN
cord-288868-qfdxri93	9	28	.	.	.
cord-288868-qfdxri93	10	1	Antigen	antigen	NN
cord-288868-qfdxri93	10	2	-	-	HYPH
cord-288868-qfdxri93	10	3	loaded	load	VBN
cord-288868-qfdxri93	10	4	dendritic	dendritic	JJ
cord-288868-qfdxri93	10	5	cells	cell	NNS
cord-288868-qfdxri93	10	6	,	,	,
cord-288868-qfdxri93	10	7	DNA	DNA	NNP
cord-288868-qfdxri93	10	8	in	in	IN
cord-288868-qfdxri93	10	9	naked	naked	JJ
cord-288868-qfdxri93	10	10	,	,	,
cord-288868-qfdxri93	10	11	formulated	formulate	VBN
cord-288868-qfdxri93	10	12	or	or	CC
cord-288868-qfdxri93	10	13	viral	viral	JJ
cord-288868-qfdxri93	10	14	form	form	NN
cord-288868-qfdxri93	10	15	,	,	,
cord-288868-qfdxri93	10	16	and	and	CC
cord-288868-qfdxri93	10	17	other	other	JJ
cord-288868-qfdxri93	10	18	delivery	delivery	NN
cord-288868-qfdxri93	10	19	systems	system	NNS
cord-288868-qfdxri93	10	20	are	be	VBP
cord-288868-qfdxri93	10	21	used	use	VBN
cord-288868-qfdxri93	10	22	to	to	TO
cord-288868-qfdxri93	10	23	maximize	maximize	VB
cord-288868-qfdxri93	10	24	immune	immune	JJ
cord-288868-qfdxri93	10	25	responses	response	NNS
cord-288868-qfdxri93	10	26	.	.	.
cord-288868-qfdxri93	11	1	Although	although	IN
cord-288868-qfdxri93	11	2	work	work	NN
cord-288868-qfdxri93	11	3	on	on	IN
cord-288868-qfdxri93	11	4	the	the	DT
cord-288868-qfdxri93	11	5	‘	'	``
cord-288868-qfdxri93	11	6	easy	easy	JJ
cord-288868-qfdxri93	11	7	’	'	''
cord-288868-qfdxri93	11	8	vaccines	vaccine	NNS
cord-288868-qfdxri93	11	9	has	have	VBZ
cord-288868-qfdxri93	11	10	already	already	RB
cord-288868-qfdxri93	11	11	been	be	VBN
cord-288868-qfdxri93	11	12	completed	complete	VBN
cord-288868-qfdxri93	11	13	,	,	,
cord-288868-qfdxri93	11	14	it	-PRON-	PRP
cord-288868-qfdxri93	11	15	is	be	VBZ
cord-288868-qfdxri93	11	16	hoped	hope	VBN
cord-288868-qfdxri93	11	17	that	that	IN
cord-288868-qfdxri93	11	18	a	a	DT
cord-288868-qfdxri93	11	19	combination	combination	NN
cord-288868-qfdxri93	11	20	of	of	IN
cord-288868-qfdxri93	11	21	conceptual	conceptual	JJ
cord-288868-qfdxri93	11	22	and	and	CC
cord-288868-qfdxri93	11	23	technical	technical	JJ
cord-288868-qfdxri93	11	24	innovation	innovation	NN
cord-288868-qfdxri93	11	25	will	will	MD
cord-288868-qfdxri93	11	26	enable	enable	VB
cord-288868-qfdxri93	11	27	the	the	DT
cord-288868-qfdxri93	11	28	development	development	NN
cord-288868-qfdxri93	11	29	of	of	IN
cord-288868-qfdxri93	11	30	more	more	RBR
cord-288868-qfdxri93	11	31	complex	complex	JJ
cord-288868-qfdxri93	11	32	and	and	CC
cord-288868-qfdxri93	11	33	sophisticated	sophisticated	JJ
cord-288868-qfdxri93	11	34	vaccines	vaccine	NNS
cord-288868-qfdxri93	11	35	in	in	IN
cord-288868-qfdxri93	11	36	the	the	DT
cord-288868-qfdxri93	11	37	future	future	NN
cord-288868-qfdxri93	11	38	.	.	.
cord-288868-qfdxri93	12	1	Vaccinology	vaccinology	NN
cord-288868-qfdxri93	12	2	at	at	IN
cord-288868-qfdxri93	12	3	the	the	DT
cord-288868-qfdxri93	12	4	beginning	beginning	NN
cord-288868-qfdxri93	12	5	of	of	IN
cord-288868-qfdxri93	12	6	the	the	DT
cord-288868-qfdxri93	12	7	21st	21st	JJ
cord-288868-qfdxri93	12	8	century	century	NN
cord-288868-qfdxri93	12	9	Andreas	Andreas	NNP
cord-288868-qfdxri93	12	10	Wack	Wack	NNP
cord-288868-qfdxri93	12	11	and	and	CC
cord-288868-qfdxri93	12	12	Rino	Rino	NNP
cord-288868-qfdxri93	12	13	Rappuoli	Rappuoli	NNP
cord-288868-qfdxri93	13	1	Today	today	NN
cord-288868-qfdxri93	13	2	,	,	,
cord-288868-qfdxri93	13	3	the	the	DT
cord-288868-qfdxri93	13	4	main	main	JJ
cord-288868-qfdxri93	13	5	challenges	challenge	NNS
cord-288868-qfdxri93	13	6	for	for	IN
cord-288868-qfdxri93	13	7	vaccinologists	vaccinologist	NNS
cord-288868-qfdxri93	13	8	include	include	VBP
cord-288868-qfdxri93	13	9	improving	improve	VBG
cord-288868-qfdxri93	13	10	vaccines	vaccine	NNS
cord-288868-qfdxri93	13	11	against	against	IN
cord-288868-qfdxri93	13	12	as	as	RB
cord-288868-qfdxri93	13	13	yet	yet	RB
cord-288868-qfdxri93	13	14	undefeated	undefeated	JJ
cord-288868-qfdxri93	13	15	pathogens	pathogen	NNS
cord-288868-qfdxri93	13	16	,	,	,
cord-288868-qfdxri93	13	17	rapid	rapid	JJ
cord-288868-qfdxri93	13	18	identification	identification	NN
cord-288868-qfdxri93	13	19	and	and	CC
cord-288868-qfdxri93	13	20	response	response	NN
cord-288868-qfdxri93	13	21	to	to	IN
cord-288868-qfdxri93	13	22	emerging	emerge	VBG
cord-288868-qfdxri93	13	23	diseases	disease	NNS
cord-288868-qfdxri93	13	24	and	and	CC
cord-288868-qfdxri93	13	25	successful	successful	JJ
cord-288868-qfdxri93	13	26	intervention	intervention	NN
cord-288868-qfdxri93	13	27	in	in	IN
cord-288868-qfdxri93	13	28	chronic	chronic	JJ
cord-288868-qfdxri93	13	29	diseases	disease	NNS
cord-288868-qfdxri93	13	30	in	in	IN
cord-288868-qfdxri93	13	31	which	which	WDT
cord-288868-qfdxri93	13	32	ongoing	ongoing	JJ
cord-288868-qfdxri93	13	33	immune	immune	JJ
cord-288868-qfdxri93	13	34	responses	response	NNS
cord-288868-qfdxri93	13	35	are	be	VBP
cord-288868-qfdxri93	13	36	insufficient	insufficient	JJ
cord-288868-qfdxri93	13	37	.	.	.
cord-288868-qfdxri93	14	1	Reverse	reverse	JJ
cord-288868-qfdxri93	14	2	genetics	genetic	NNS
cord-288868-qfdxri93	14	3	and	and	CC
cord-288868-qfdxri93	14	4	reverse	reverse	VB
cord-288868-qfdxri93	14	5	vaccinology	vaccinology	NN
cord-288868-qfdxri93	14	6	are	be	VBP
cord-288868-qfdxri93	14	7	now	now	RB
cord-288868-qfdxri93	14	8	used	use	VBN
cord-288868-qfdxri93	14	9	to	to	TO
cord-288868-qfdxri93	14	10	generate	generate	VB
cord-288868-qfdxri93	14	11	rapidly	rapidly	RB
cord-288868-qfdxri93	14	12	new	new	JJ
cord-288868-qfdxri93	14	13	vaccine	vaccine	NN
cord-288868-qfdxri93	14	14	strains	strain	NNS
cord-288868-qfdxri93	14	15	and	and	CC
cord-288868-qfdxri93	14	16	to	to	IN
cord-288868-qfdxri93	14	17	mine	mine	PRP$
cord-288868-qfdxri93	14	18	whole	whole	JJ
cord-288868-qfdxri93	14	19	genomes	genome	NNS
cord-288868-qfdxri93	14	20	in	in	IN
cord-288868-qfdxri93	14	21	the	the	DT
cord-288868-qfdxri93	14	22	search	search	NN
cord-288868-qfdxri93	14	23	for	for	IN
cord-288868-qfdxri93	14	24	promising	promising	JJ
cord-288868-qfdxri93	14	25	antigens	antigen	NNS
cord-288868-qfdxri93	14	26	.	.	.
cord-288868-qfdxri93	15	1	The	the	DT
cord-288868-qfdxri93	15	2	rational	rational	JJ
cord-288868-qfdxri93	15	3	design	design	NN
cord-288868-qfdxri93	15	4	of	of	IN
cord-288868-qfdxri93	15	5	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	15	6	has	have	VBZ
cord-288868-qfdxri93	15	7	become	become	VBN
cord-288868-qfdxri93	15	8	possible	possible	JJ
cord-288868-qfdxri93	15	9	as	as	IN
cord-288868-qfdxri93	15	10	a	a	DT
cord-288868-qfdxri93	15	11	result	result	NN
cord-288868-qfdxri93	15	12	of	of	IN
cord-288868-qfdxri93	15	13	the	the	DT
cord-288868-qfdxri93	15	14	discovery	discovery	NN
cord-288868-qfdxri93	15	15	of	of	IN
cord-288868-qfdxri93	15	16	the	the	DT
cord-288868-qfdxri93	15	17	receptors	receptor	NNS
cord-288868-qfdxri93	15	18	that	that	WDT
cord-288868-qfdxri93	15	19	recognize	recognize	VBP
cord-288868-qfdxri93	15	20	microbial	microbial	JJ
cord-288868-qfdxri93	15	21	patterns	pattern	NNS
cord-288868-qfdxri93	15	22	and	and	CC
cord-288868-qfdxri93	15	23	lead	lead	VBP
cord-288868-qfdxri93	15	24	to	to	IN
cord-288868-qfdxri93	15	25	dendritic	dendritic	JJ
cord-288868-qfdxri93	15	26	cell	cell	NN
cord-288868-qfdxri93	15	27	activation	activation	NN
cord-288868-qfdxri93	15	28	.	.	.
cord-288868-qfdxri93	16	1	Antigen	antigen	NN
cord-288868-qfdxri93	16	2	-	-	HYPH
cord-288868-qfdxri93	16	3	loaded	load	VBN
cord-288868-qfdxri93	16	4	dendritic	dendritic	JJ
cord-288868-qfdxri93	16	5	cells	cell	NNS
cord-288868-qfdxri93	16	6	,	,	,
cord-288868-qfdxri93	16	7	DNA	DNA	NNP
cord-288868-qfdxri93	16	8	in	in	IN
cord-288868-qfdxri93	16	9	naked	naked	JJ
cord-288868-qfdxri93	16	10	,	,	,
cord-288868-qfdxri93	16	11	formulated	formulate	VBN
cord-288868-qfdxri93	16	12	or	or	CC
cord-288868-qfdxri93	16	13	viral	viral	JJ
cord-288868-qfdxri93	16	14	form	form	NN
cord-288868-qfdxri93	16	15	,	,	,
cord-288868-qfdxri93	16	16	and	and	CC
cord-288868-qfdxri93	16	17	other	other	JJ
cord-288868-qfdxri93	16	18	delivery	delivery	NN
cord-288868-qfdxri93	16	19	systems	system	NNS
cord-288868-qfdxri93	16	20	are	be	VBP
cord-288868-qfdxri93	16	21	used	use	VBN
cord-288868-qfdxri93	16	22	to	to	TO
cord-288868-qfdxri93	16	23	maximize	maximize	VB
cord-288868-qfdxri93	16	24	immune	immune	JJ
cord-288868-qfdxri93	16	25	responses	response	NNS
cord-288868-qfdxri93	16	26	.	.	.
cord-288868-qfdxri93	17	1	Although	although	IN
cord-288868-qfdxri93	17	2	work	work	NN
cord-288868-qfdxri93	17	3	on	on	IN
cord-288868-qfdxri93	17	4	the	the	DT
cord-288868-qfdxri93	17	5	'	'	``
cord-288868-qfdxri93	17	6	easy	easy	JJ
cord-288868-qfdxri93	17	7	'	'	''
cord-288868-qfdxri93	17	8	vaccines	vaccine	NNS
cord-288868-qfdxri93	17	9	has	have	VBZ
cord-288868-qfdxri93	17	10	already	already	RB
cord-288868-qfdxri93	17	11	been	be	VBN
cord-288868-qfdxri93	17	12	completed	complete	VBN
cord-288868-qfdxri93	17	13	,	,	,
cord-288868-qfdxri93	17	14	it	-PRON-	PRP
cord-288868-qfdxri93	17	15	is	be	VBZ
cord-288868-qfdxri93	17	16	hoped	hope	VBN
cord-288868-qfdxri93	17	17	that	that	IN
cord-288868-qfdxri93	17	18	a	a	DT
cord-288868-qfdxri93	17	19	combination	combination	NN
cord-288868-qfdxri93	17	20	of	of	IN
cord-288868-qfdxri93	17	21	conceptual	conceptual	JJ
cord-288868-qfdxri93	17	22	and	and	CC
cord-288868-qfdxri93	17	23	technical	technical	JJ
cord-288868-qfdxri93	17	24	innovation	innovation	NN
cord-288868-qfdxri93	17	25	will	will	MD
cord-288868-qfdxri93	17	26	enable	enable	VB
cord-288868-qfdxri93	17	27	the	the	DT
cord-288868-qfdxri93	17	28	development	development	NN
cord-288868-qfdxri93	17	29	of	of	IN
cord-288868-qfdxri93	17	30	more	more	RBR
cord-288868-qfdxri93	17	31	complex	complex	JJ
cord-288868-qfdxri93	17	32	and	and	CC
cord-288868-qfdxri93	17	33	sophisticated	sophisticated	JJ
cord-288868-qfdxri93	17	34	vaccines	vaccine	NNS
cord-288868-qfdxri93	17	35	in	in	IN
cord-288868-qfdxri93	17	36	the	the	DT
cord-288868-qfdxri93	17	37	future	future	NN
cord-288868-qfdxri93	17	38	.	.	.
cord-288868-qfdxri93	18	1	Although	although	IN
cord-288868-qfdxri93	18	2	the	the	DT
cord-288868-qfdxri93	18	3	eradication	eradication	NN
cord-288868-qfdxri93	18	4	of	of	IN
cord-288868-qfdxri93	18	5	smallpox	smallpox	NN
cord-288868-qfdxri93	18	6	in	in	IN
cord-288868-qfdxri93	18	7	the	the	DT
cord-288868-qfdxri93	18	8	1970s	1970	NNS
cord-288868-qfdxri93	18	9	and	and	CC
cord-288868-qfdxri93	18	10	of	of	IN
cord-288868-qfdxri93	18	11	poliomyelitis	poliomyelitis	NN
cord-288868-qfdxri93	18	12	hopefully	hopefully	RB
cord-288868-qfdxri93	18	13	in	in	IN
cord-288868-qfdxri93	18	14	the	the	DT
cord-288868-qfdxri93	18	15	coming	come	VBG
cord-288868-qfdxri93	18	16	years	year	NNS
cord-288868-qfdxri93	18	17	mark	mark	VBP
cord-288868-qfdxri93	18	18	two	two	CD
cord-288868-qfdxri93	18	19	of	of	IN
cord-288868-qfdxri93	18	20	the	the	DT
cord-288868-qfdxri93	18	21	most	most	RBS
cord-288868-qfdxri93	18	22	important	important	JJ
cord-288868-qfdxri93	18	23	milestones	milestone	NNS
cord-288868-qfdxri93	18	24	in	in	IN
cord-288868-qfdxri93	18	25	medical	medical	JJ
cord-288868-qfdxri93	18	26	history	history	NN
cord-288868-qfdxri93	18	27	,	,	,
cord-288868-qfdxri93	18	28	we	-PRON-	PRP
cord-288868-qfdxri93	18	29	now	now	RB
cord-288868-qfdxri93	18	30	face	face	VBP
cord-288868-qfdxri93	18	31	an	an	DT
cord-288868-qfdxri93	18	32	unprecedented	unprecedented	JJ
cord-288868-qfdxri93	18	33	succession	succession	NN
cord-288868-qfdxri93	18	34	of	of	IN
cord-288868-qfdxri93	18	35	new	new	JJ
cord-288868-qfdxri93	18	36	pathogens	pathogen	NNS
cord-288868-qfdxri93	18	37	which	which	WDT
cord-288868-qfdxri93	18	38	jump	jump	VBP
cord-288868-qfdxri93	18	39	species	species	NN
cord-288868-qfdxri93	18	40	barriers	barrier	NNS
cord-288868-qfdxri93	18	41	to	to	TO
cord-288868-qfdxri93	18	42	infect	infect	VB
cord-288868-qfdxri93	18	43	humans	human	NNS
cord-288868-qfdxri93	18	44	,	,	,
cord-288868-qfdxri93	18	45	and	and	CC
cord-288868-qfdxri93	18	46	the	the	DT
cord-288868-qfdxri93	18	47	frustration	frustration	NN
cord-288868-qfdxri93	18	48	deriving	derive	VBG
cord-288868-qfdxri93	18	49	from	from	IN
cord-288868-qfdxri93	18	50	the	the	DT
cord-288868-qfdxri93	18	51	inability	inability	NN
cord-288868-qfdxri93	18	52	to	to	TO
cord-288868-qfdxri93	18	53	control	control	VB
cord-288868-qfdxri93	18	54	devastating	devastating	JJ
cord-288868-qfdxri93	18	55	diseases	disease	NNS
cord-288868-qfdxri93	18	56	such	such	JJ
cord-288868-qfdxri93	18	57	as	as	IN
cord-288868-qfdxri93	18	58	HIV	HIV	NNP
cord-288868-qfdxri93	18	59	,	,	,
cord-288868-qfdxri93	18	60	malaria	malaria	NN
cord-288868-qfdxri93	18	61	and	and	CC
cord-288868-qfdxri93	18	62	tuberculosis	tuberculosis	NN
cord-288868-qfdxri93	18	63	.	.	.
cord-288868-qfdxri93	19	1	This	this	DT
cord-288868-qfdxri93	19	2	review	review	NN
cord-288868-qfdxri93	19	3	will	will	MD
cord-288868-qfdxri93	19	4	cover	cover	VB
cord-288868-qfdxri93	19	5	the	the	DT
cord-288868-qfdxri93	19	6	recent	recent	JJ
cord-288868-qfdxri93	19	7	progress	progress	NN
cord-288868-qfdxri93	19	8	in	in	IN
cord-288868-qfdxri93	19	9	vaccinology	vaccinology	NN
cord-288868-qfdxri93	19	10	(	(	-LRB-
cord-288868-qfdxri93	19	11	Figure	figure	NN
cord-288868-qfdxri93	19	12	1	1	CD
cord-288868-qfdxri93	19	13	)	)	-RRB-
cord-288868-qfdxri93	19	14	,	,	,
cord-288868-qfdxri93	19	15	largely	largely	RB
cord-288868-qfdxri93	19	16	resulting	result	VBG
cord-288868-qfdxri93	19	17	from	from	IN
cord-288868-qfdxri93	19	18	dramatic	dramatic	JJ
cord-288868-qfdxri93	19	19	technical	technical	JJ
cord-288868-qfdxri93	19	20	innovation	innovation	NN
cord-288868-qfdxri93	19	21	that	that	WDT
cord-288868-qfdxri93	19	22	is	be	VBZ
cord-288868-qfdxri93	19	23	now	now	RB
cord-288868-qfdxri93	19	24	reaching	reach	VBG
cord-288868-qfdxri93	19	25	the	the	DT
cord-288868-qfdxri93	19	26	clinic	clinic	NN
cord-288868-qfdxri93	19	27	,	,	,
cord-288868-qfdxri93	19	28	as	as	RB
cord-288868-qfdxri93	19	29	well	well	RB
cord-288868-qfdxri93	19	30	as	as	IN
cord-288868-qfdxri93	19	31	the	the	DT
cord-288868-qfdxri93	19	32	huge	huge	JJ
cord-288868-qfdxri93	19	33	challenges	challenge	NNS
cord-288868-qfdxri93	19	34	posed	pose	VBN
cord-288868-qfdxri93	19	35	by	by	IN
cord-288868-qfdxri93	19	36	old	old	JJ
cord-288868-qfdxri93	19	37	and	and	CC
cord-288868-qfdxri93	19	38	new	new	JJ
cord-288868-qfdxri93	19	39	pathogens	pathogen	NNS
cord-288868-qfdxri93	19	40	that	that	WDT
cord-288868-qfdxri93	19	41	are	be	VBP
cord-288868-qfdxri93	19	42	facing	face	VBG
cord-288868-qfdxri93	19	43	us	-PRON-	PRP
cord-288868-qfdxri93	19	44	.	.	.
cord-288868-qfdxri93	20	1	The	the	DT
cord-288868-qfdxri93	20	2	three	three	CD
cord-288868-qfdxri93	20	3	'	'	POS
cord-288868-qfdxri93	20	4	big	big	JJ
cord-288868-qfdxri93	20	5	killers	killer	NNS
cord-288868-qfdxri93	20	6	'	'	''
cord-288868-qfdxri93	20	7	,	,	,
cord-288868-qfdxri93	20	8	the	the	DT
cord-288868-qfdxri93	20	9	pathogens	pathogen	NNS
cord-288868-qfdxri93	20	10	that	that	WDT
cord-288868-qfdxri93	20	11	most	most	RBS
cord-288868-qfdxri93	20	12	heavily	heavily	RB
cord-288868-qfdxri93	20	13	afflict	afflict	VBP
cord-288868-qfdxri93	20	14	global	global	JJ
cord-288868-qfdxri93	20	15	health	health	NN
cord-288868-qfdxri93	20	16	,	,	,
cord-288868-qfdxri93	20	17	are	be	VBP
cord-288868-qfdxri93	20	18	HIV	HIV	NNP
cord-288868-qfdxri93	20	19	,	,	,
cord-288868-qfdxri93	20	20	mycobacterium	mycobacterium	NN
cord-288868-qfdxri93	20	21	and	and	CC
cord-288868-qfdxri93	20	22	plas	plas	NNP
cord-288868-qfdxri93	20	23	-	-	HYPH
cord-288868-qfdxri93	20	24	modium	modium	NNP
cord-288868-qfdxri93	20	25	.	.	.
cord-288868-qfdxri93	21	1	Whereas	whereas	IN
cord-288868-qfdxri93	21	2	the	the	DT
cord-288868-qfdxri93	21	3	latter	latter	JJ
cord-288868-qfdxri93	21	4	two	two	CD
cord-288868-qfdxri93	21	5	represent	represent	VBP
cord-288868-qfdxri93	21	6	long	long	JJ
cord-288868-qfdxri93	21	7	-	-	HYPH
cord-288868-qfdxri93	21	8	term	term	NN
cord-288868-qfdxri93	21	9	companions	companion	NNS
cord-288868-qfdxri93	21	10	of	of	IN
cord-288868-qfdxri93	21	11	the	the	DT
cord-288868-qfdxri93	21	12	human	human	JJ
cord-288868-qfdxri93	21	13	species	specie	NNS
cord-288868-qfdxri93	21	14	,	,	,
cord-288868-qfdxri93	21	15	HIV	HIV	NNP
cord-288868-qfdxri93	21	16	is	be	VBZ
cord-288868-qfdxri93	21	17	a	a	DT
cord-288868-qfdxri93	21	18	virus	virus	NN
cord-288868-qfdxri93	21	19	that	that	WDT
cord-288868-qfdxri93	21	20	spread	spread	VBD
cord-288868-qfdxri93	21	21	in	in	IN
cord-288868-qfdxri93	21	22	the	the	DT
cord-288868-qfdxri93	21	23	human	human	JJ
cord-288868-qfdxri93	21	24	population	population	NN
cord-288868-qfdxri93	21	25	only	only	RB
cord-288868-qfdxri93	21	26	about	about	IN
cord-288868-qfdxri93	21	27	25	25	CD
cord-288868-qfdxri93	21	28	years	year	NNS
cord-288868-qfdxri93	21	29	ago	ago	RB
cord-288868-qfdxri93	21	30	and	and	CC
cord-288868-qfdxri93	21	31	has	have	VBZ
cord-288868-qfdxri93	21	32	a	a	DT
cord-288868-qfdxri93	21	33	nonhuman	nonhuman	NN
cord-288868-qfdxri93	21	34	primate	primate	JJ
cord-288868-qfdxri93	21	35	origin	origin	NN
cord-288868-qfdxri93	21	36	[	[	-LRB-
cord-288868-qfdxri93	21	37	1	1	CD
cord-288868-qfdxri93	21	38	]	]	-RRB-
cord-288868-qfdxri93	21	39	.	.	.
cord-288868-qfdxri93	22	1	In	in	IN
cord-288868-qfdxri93	22	2	fact	fact	NN
cord-288868-qfdxri93	22	3	,	,	,
cord-288868-qfdxri93	22	4	most	most	JJS
cord-288868-qfdxri93	22	5	,	,	,
cord-288868-qfdxri93	22	6	if	if	IN
cord-288868-qfdxri93	22	7	not	not	RB
cord-288868-qfdxri93	22	8	all	all	DT
cord-288868-qfdxri93	22	9	,	,	,
cord-288868-qfdxri93	22	10	of	of	IN
cord-288868-qfdxri93	22	11	the	the	DT
cord-288868-qfdxri93	22	12	recently	recently	RB
cord-288868-qfdxri93	22	13	emerging	emerge	VBG
cord-288868-qfdxri93	22	14	diseases	disease	NNS
cord-288868-qfdxri93	22	15	go	go	VBP
cord-288868-qfdxri93	22	16	back	back	RB
cord-288868-qfdxri93	22	17	to	to	IN
cord-288868-qfdxri93	22	18	animal	animal	NN
cord-288868-qfdxri93	22	19	reservoirs	reservoir	NNS
cord-288868-qfdxri93	22	20	,	,	,
cord-288868-qfdxri93	22	21	from	from	IN
cord-288868-qfdxri93	22	22	which	which	WDT
cord-288868-qfdxri93	22	23	they	-PRON-	PRP
cord-288868-qfdxri93	22	24	infect	infect	VBP
cord-288868-qfdxri93	22	25	humans	human	NNS
cord-288868-qfdxri93	22	26	through	through	IN
cord-288868-qfdxri93	22	27	close	close	JJ
cord-288868-qfdxri93	22	28	contact	contact	NN
cord-288868-qfdxri93	22	29	during	during	IN
cord-288868-qfdxri93	22	30	hunting	hunting	NN
cord-288868-qfdxri93	22	31	and	and	CC
cord-288868-qfdxri93	22	32	farming	farming	NN
cord-288868-qfdxri93	22	33	,	,	,
cord-288868-qfdxri93	22	34	in	in	IN
cord-288868-qfdxri93	22	35	live	live	JJ
cord-288868-qfdxri93	22	36	animal	animal	NN
cord-288868-qfdxri93	22	37	markets	market	NNS
cord-288868-qfdxri93	22	38	or	or	CC
cord-288868-qfdxri93	22	39	through	through	IN
cord-288868-qfdxri93	22	40	food	food	NN
cord-288868-qfdxri93	22	41	processing	processing	NN
cord-288868-qfdxri93	22	42	,	,	,
cord-288868-qfdxri93	22	43	preparation	preparation	NN
cord-288868-qfdxri93	22	44	or	or	CC
cord-288868-qfdxri93	22	45	consumption	consumption	NN
cord-288868-qfdxri93	22	46	.	.	.
cord-288868-qfdxri93	23	1	An	an	DT
cord-288868-qfdxri93	23	2	example	example	NN
cord-288868-qfdxri93	23	3	is	be	VBZ
cord-288868-qfdxri93	23	4	Ebola	Ebola	NNP
cord-288868-qfdxri93	23	5	virus	virus	NN
cord-288868-qfdxri93	23	6	,	,	,
cord-288868-qfdxri93	23	7	which	which	WDT
cord-288868-qfdxri93	23	8	,	,	,
cord-288868-qfdxri93	23	9	after	after	IN
cord-288868-qfdxri93	23	10	three	three	CD
cord-288868-qfdxri93	23	11	outbreaks	outbreak	NNS
cord-288868-qfdxri93	23	12	between	between	IN
cord-288868-qfdxri93	23	13	1976	1976	CD
cord-288868-qfdxri93	23	14	and	and	CC
cord-288868-qfdxri93	23	15	1979	1979	CD
cord-288868-qfdxri93	23	16	,	,	,
cord-288868-qfdxri93	23	17	has	have	VBZ
cord-288868-qfdxri93	23	18	appeared	appear	VBN
cord-288868-qfdxri93	23	19	in	in	IN
cord-288868-qfdxri93	23	20	the	the	DT
cord-288868-qfdxri93	23	21	human	human	JJ
cord-288868-qfdxri93	23	22	population	population	NN
cord-288868-qfdxri93	23	23	nine	nine	CD
cord-288868-qfdxri93	23	24	times	time	NNS
cord-288868-qfdxri93	23	25	since	since	IN
cord-288868-qfdxri93	23	26	1994	1994	CD
cord-288868-qfdxri93	23	27	,	,	,
cord-288868-qfdxri93	23	28	with	with	IN
cord-288868-qfdxri93	23	29	each	each	DT
cord-288868-qfdxri93	23	30	outbreak	outbreak	NN
cord-288868-qfdxri93	23	31	resulting	result	VBG
cord-288868-qfdxri93	23	32	from	from	IN
cord-288868-qfdxri93	23	33	the	the	DT
cord-288868-qfdxri93	23	34	handling	handling	NN
cord-288868-qfdxri93	23	35	of	of	IN
cord-288868-qfdxri93	23	36	dead	dead	JJ
cord-288868-qfdxri93	23	37	gorillas	gorilla	NNS
cord-288868-qfdxri93	23	38	,	,	,
cord-288868-qfdxri93	23	39	chimpanzees	chimpanzee	NNS
cord-288868-qfdxri93	23	40	or	or	CC
cord-288868-qfdxri93	23	41	duikers	duiker	NNS
cord-288868-qfdxri93	23	42	,	,	,
cord-288868-qfdxri93	23	43	which	which	WDT
cord-288868-qfdxri93	23	44	in	in	IN
cord-288868-qfdxri93	23	45	turn	turn	NN
cord-288868-qfdxri93	23	46	are	be	VBP
cord-288868-qfdxri93	23	47	thought	think	VBN
cord-288868-qfdxri93	23	48	to	to	TO
cord-288868-qfdxri93	23	49	have	have	VB
cord-288868-qfdxri93	23	50	been	be	VBN
cord-288868-qfdxri93	23	51	infected	infect	VBN
cord-288868-qfdxri93	23	52	by	by	IN
cord-288868-qfdxri93	23	53	an	an	DT
cord-288868-qfdxri93	23	54	unknown	unknown	JJ
cord-288868-qfdxri93	23	55	natural	natural	JJ
cord-288868-qfdxri93	23	56	host	host	NN
cord-288868-qfdxri93	23	57	[	[	-LRB-
cord-288868-qfdxri93	23	58	2	2	CD
cord-288868-qfdxri93	23	59	]	]	-RRB-
cord-288868-qfdxri93	23	60	.	.	.
cord-288868-qfdxri93	24	1	The	the	DT
cord-288868-qfdxri93	24	2	variant	variant	JJ
cord-288868-qfdxri93	24	3	Creutzfeldt	Creutzfeldt	NNP
cord-288868-qfdxri93	24	4	-	-	HYPH
cord-288868-qfdxri93	24	5	Jacob	Jacob	NNP
cord-288868-qfdxri93	24	6	disease	disease	NN
cord-288868-qfdxri93	24	7	reached	reach	VBD
cord-288868-qfdxri93	24	8	the	the	DT
cord-288868-qfdxri93	24	9	population	population	NN
cord-288868-qfdxri93	24	10	through	through	IN
cord-288868-qfdxri93	24	11	the	the	DT
cord-288868-qfdxri93	24	12	food	food	NN
cord-288868-qfdxri93	24	13	chain	chain	NN
cord-288868-qfdxri93	24	14	,	,	,
cord-288868-qfdxri93	24	15	from	from	IN
cord-288868-qfdxri93	24	16	'	'	``
cord-288868-qfdxri93	24	17	rendered	render	VBN
cord-288868-qfdxri93	24	18	'	'	''
cord-288868-qfdxri93	24	19	sheep	sheep	NN
cord-288868-qfdxri93	24	20	and	and	CC
cord-288868-qfdxri93	24	21	cow	cow	NN
cord-288868-qfdxri93	24	22	carcasses	carcass	NNS
cord-288868-qfdxri93	24	23	fed	feed	VBN
cord-288868-qfdxri93	24	24	to	to	IN
cord-288868-qfdxri93	24	25	cows	cow	NNS
cord-288868-qfdxri93	24	26	which	which	WDT
cord-288868-qfdxri93	24	27	were	be	VBD
cord-288868-qfdxri93	24	28	subsequently	subsequently	RB
cord-288868-qfdxri93	24	29	consumed	consume	VBN
cord-288868-qfdxri93	24	30	by	by	IN
cord-288868-qfdxri93	24	31	humans	human	NNS
cord-288868-qfdxri93	24	32	.	.	.
cord-288868-qfdxri93	25	1	The	the	DT
cord-288868-qfdxri93	25	2	severe	severe	JJ
cord-288868-qfdxri93	25	3	acute	acute	JJ
cord-288868-qfdxri93	25	4	respiratory	respiratory	JJ
cord-288868-qfdxri93	25	5	syndrome	syndrome	NN
cord-288868-qfdxri93	25	6	(	(	-LRB-
cord-288868-qfdxri93	25	7	SARS)-coronavirus	SARS)-coronavirus	NNP
cord-288868-qfdxri93	25	8	sequences	sequence	NNS
cord-288868-qfdxri93	25	9	from	from	IN
cord-288868-qfdxri93	25	10	the	the	DT
cord-288868-qfdxri93	25	11	earliest	early	JJS
cord-288868-qfdxri93	25	12	identified	identify	VBN
cord-288868-qfdxri93	25	13	cases	case	NNS
cord-288868-qfdxri93	25	14	are	be	VBP
cord-288868-qfdxri93	25	15	identical	identical	JJ
cord-288868-qfdxri93	25	16	to	to	IN
cord-288868-qfdxri93	25	17	those	those	DT
cord-288868-qfdxri93	25	18	found	find	VBN
cord-288868-qfdxri93	25	19	in	in	IN
cord-288868-qfdxri93	25	20	palm	palm	NN
cord-288868-qfdxri93	25	21	civets	civet	NNS
cord-288868-qfdxri93	25	22	and	and	CC
cord-288868-qfdxri93	25	23	raccoon	raccoon	NN
cord-288868-qfdxri93	25	24	dogs	dog	NNS
cord-288868-qfdxri93	25	25	in	in	IN
cord-288868-qfdxri93	25	26	animal	animal	NN
cord-288868-qfdxri93	25	27	markets	market	NNS
cord-288868-qfdxri93	25	28	and	and	CC
cord-288868-qfdxri93	25	29	farms	farm	NNS
cord-288868-qfdxri93	25	30	[	[	-LRB-
cord-288868-qfdxri93	25	31	3	3	CD
cord-288868-qfdxri93	25	32	]	]	-RRB-
cord-288868-qfdxri93	25	33	,	,	,
cord-288868-qfdxri93	25	34	strongly	strongly	RB
cord-288868-qfdxri93	25	35	suggesting	suggest	VBG
cord-288868-qfdxri93	25	36	an	an	DT
cord-288868-qfdxri93	25	37	animal	animal	NN
cord-288868-qfdxri93	25	38	origin	origin	NN
cord-288868-qfdxri93	25	39	for	for	IN
cord-288868-qfdxri93	25	40	this	this	DT
cord-288868-qfdxri93	25	41	disease	disease	NN
cord-288868-qfdxri93	25	42	.	.	.
cord-288868-qfdxri93	26	1	Rapidly	rapidly	RB
cord-288868-qfdxri93	26	2	changing	change	VBG
cord-288868-qfdxri93	26	3	ecosystems	ecosystem	NNS
cord-288868-qfdxri93	26	4	and	and	CC
cord-288868-qfdxri93	26	5	human	human	JJ
cord-288868-qfdxri93	26	6	behavior	behavior	NN
cord-288868-qfdxri93	26	7	,	,	,
cord-288868-qfdxri93	26	8	an	an	DT
cord-288868-qfdxri93	26	9	ever	ever	RB
cord-288868-qfdxri93	26	10	-	-	HYPH
cord-288868-qfdxri93	26	11	increasing	increase	VBG
cord-288868-qfdxri93	26	12	density	density	NN
cord-288868-qfdxri93	26	13	of	of	IN
cord-288868-qfdxri93	26	14	human	human	NN
cord-288868-qfdxri93	26	15	and	and	CC
cord-288868-qfdxri93	26	16	(	(	-LRB-
cord-288868-qfdxri93	26	17	farmed	farm	VBN
cord-288868-qfdxri93	26	18	)	)	-RRB-
cord-288868-qfdxri93	26	19	animal	animal	NN
cord-288868-qfdxri93	26	20	populations	population	NNS
cord-288868-qfdxri93	26	21	and	and	CC
cord-288868-qfdxri93	26	22	their	-PRON-	PRP$
cord-288868-qfdxri93	26	23	close	close	JJ
cord-288868-qfdxri93	26	24	vicinity	vicinity	NN
cord-288868-qfdxri93	26	25	,	,	,
cord-288868-qfdxri93	26	26	poverty	poverty	NN
cord-288868-qfdxri93	26	27	,	,	,
cord-288868-qfdxri93	26	28	a	a	DT
cord-288868-qfdxri93	26	29	high	high	JJ
cord-288868-qfdxri93	26	30	degree	degree	NN
cord-288868-qfdxri93	26	31	of	of	IN
cord-288868-qfdxri93	26	32	mobility	mobility	NN
cord-288868-qfdxri93	26	33	and	and	CC
cord-288868-qfdxri93	26	34	many	many	JJ
cord-288868-qfdxri93	26	35	other	other	JJ
cord-288868-qfdxri93	26	36	factors	factor	NNS
cord-288868-qfdxri93	26	37	contribute	contribute	VBP
cord-288868-qfdxri93	26	38	to	to	IN
cord-288868-qfdxri93	26	39	the	the	DT
cord-288868-qfdxri93	26	40	more	more	RBR
cord-288868-qfdxri93	26	41	frequent	frequent	JJ
cord-288868-qfdxri93	26	42	occurrence	occurrence	NN
cord-288868-qfdxri93	26	43	and	and	CC
cord-288868-qfdxri93	26	44	often	often	RB
cord-288868-qfdxri93	26	45	rapid	rapid	JJ
cord-288868-qfdxri93	26	46	dissemination	dissemination	NN
cord-288868-qfdxri93	26	47	of	of	IN
cord-288868-qfdxri93	26	48	new	new	JJ
cord-288868-qfdxri93	26	49	diseases	disease	NNS
cord-288868-qfdxri93	26	50	.	.	.
cord-288868-qfdxri93	27	1	Another	another	DT
cord-288868-qfdxri93	27	2	example	example	NN
cord-288868-qfdxri93	27	3	of	of	IN
cord-288868-qfdxri93	27	4	this	this	DT
cord-288868-qfdxri93	27	5	is	be	VBZ
cord-288868-qfdxri93	27	6	the	the	DT
cord-288868-qfdxri93	27	7	arrival	arrival	NN
cord-288868-qfdxri93	27	8	and	and	CC
cord-288868-qfdxri93	27	9	persistence	persistence	NN
cord-288868-qfdxri93	27	10	of	of	IN
cord-288868-qfdxri93	27	11	West	West	NNP
cord-288868-qfdxri93	27	12	Nile	Nile	NNP
cord-288868-qfdxri93	27	13	virus	virus	NN
cord-288868-qfdxri93	27	14	in	in	IN
cord-288868-qfdxri93	27	15	the	the	DT
cord-288868-qfdxri93	27	16	USA	USA	NNP
cord-288868-qfdxri93	27	17	,	,	,
cord-288868-qfdxri93	27	18	which	which	WDT
cord-288868-qfdxri93	27	19	is	be	VBZ
cord-288868-qfdxri93	27	20	probably	probably	RB
cord-288868-qfdxri93	27	21	a	a	DT
cord-288868-qfdxri93	27	22	result	result	NN
cord-288868-qfdxri93	27	23	of	of	IN
cord-288868-qfdxri93	27	24	increased	increase	VBN
cord-288868-qfdxri93	27	25	mobility	mobility	NN
cord-288868-qfdxri93	27	26	,	,	,
cord-288868-qfdxri93	27	27	an	an	DT
cord-288868-qfdxri93	27	28	exceptionally	exceptionally	RB
cord-288868-qfdxri93	27	29	broad	broad	JJ
cord-288868-qfdxri93	27	30	host	host	NN
cord-288868-qfdxri93	27	31	range	range	NN
cord-288868-qfdxri93	27	32	and	and	CC
cord-288868-qfdxri93	27	33	climatic	climatic	JJ
cord-288868-qfdxri93	27	34	changes	change	NNS
cord-288868-qfdxri93	27	35	[	[	-LRB-
cord-288868-qfdxri93	27	36	4	4	CD
cord-288868-qfdxri93	27	37	]	]	-RRB-
cord-288868-qfdxri93	27	38	.	.	.
cord-288868-qfdxri93	28	1	Among	among	IN
cord-288868-qfdxri93	28	2	the	the	DT
cord-288868-qfdxri93	28	3	reemerging	reemerge	VBG
cord-288868-qfdxri93	28	4	diseases	disease	NNS
cord-288868-qfdxri93	28	5	of	of	IN
cord-288868-qfdxri93	28	6	the	the	DT
cord-288868-qfdxri93	28	7	past	past	JJ
cord-288868-qfdxri93	28	8	few	few	JJ
cord-288868-qfdxri93	28	9	years	year	NNS
cord-288868-qfdxri93	28	10	,	,	,
cord-288868-qfdxri93	28	11	diphtheria	diphtheria	NN
cord-288868-qfdxri93	28	12	and	and	CC
cord-288868-qfdxri93	28	13	cholera	cholera	NN
cord-288868-qfdxri93	28	14	should	should	MD
cord-288868-qfdxri93	28	15	be	be	VB
cord-288868-qfdxri93	28	16	mentioned	mention	VBN
cord-288868-qfdxri93	28	17	[	[	-LRB-
cord-288868-qfdxri93	28	18	5	5	CD
cord-288868-qfdxri93	28	19	]	]	-RRB-
cord-288868-qfdxri93	28	20	,	,	,
cord-288868-qfdxri93	28	21	as	as	RB
cord-288868-qfdxri93	28	22	well	well	RB
cord-288868-qfdxri93	28	23	as	as	IN
cord-288868-qfdxri93	28	24	the	the	DT
cord-288868-qfdxri93	28	25	frequent	frequent	JJ
cord-288868-qfdxri93	28	26	appearance	appearance	NN
cord-288868-qfdxri93	28	27	of	of	IN
cord-288868-qfdxri93	28	28	multidrug	multidrug	NN
cord-288868-qfdxri93	28	29	-	-	HYPH
cord-288868-qfdxri93	28	30	resistant	resistant	JJ
cord-288868-qfdxri93	28	31	bacteria	bacteria	NNS
cord-288868-qfdxri93	28	32	and	and	CC
cord-288868-qfdxri93	28	33	the	the	DT
cord-288868-qfdxri93	28	34	cases	case	NNS
cord-288868-qfdxri93	28	35	of	of	IN
cord-288868-qfdxri93	28	36	anthrax	anthrax	NN
cord-288868-qfdxri93	28	37	infection	infection	NN
cord-288868-qfdxri93	28	38	as	as	IN
cord-288868-qfdxri93	28	39	a	a	DT
cord-288868-qfdxri93	28	40	result	result	NN
cord-288868-qfdxri93	28	41	of	of	IN
cord-288868-qfdxri93	28	42	deliberate	deliberate	JJ
cord-288868-qfdxri93	28	43	release	release	NN
cord-288868-qfdxri93	28	44	in	in	IN
cord-288868-qfdxri93	28	45	2001	2001	CD
cord-288868-qfdxri93	28	46	.	.	.
cord-288868-qfdxri93	29	1	In	in	IN
cord-288868-qfdxri93	29	2	the	the	DT
cord-288868-qfdxri93	29	3	case	case	NN
cord-288868-qfdxri93	29	4	of	of	IN
cord-288868-qfdxri93	29	5	influenza	influenza	NN
cord-288868-qfdxri93	29	6	,	,	,
cord-288868-qfdxri93	29	7	concern	concern	NN
cord-288868-qfdxri93	29	8	for	for	IN
cord-288868-qfdxri93	29	9	the	the	DT
cord-288868-qfdxri93	29	10	advent	advent	NN
cord-288868-qfdxri93	29	11	of	of	IN
cord-288868-qfdxri93	29	12	a	a	DT
cord-288868-qfdxri93	29	13	new	new	JJ
cord-288868-qfdxri93	29	14	pandemic	pandemic	NN
cord-288868-qfdxri93	29	15	has	have	VBZ
cord-288868-qfdxri93	29	16	been	be	VBN
cord-288868-qfdxri93	29	17	fuelled	fuel	VBN
cord-288868-qfdxri93	29	18	by	by	IN
cord-288868-qfdxri93	29	19	reports	report	NNS
cord-288868-qfdxri93	29	20	of	of	IN
cord-288868-qfdxri93	29	21	89	89	CD
cord-288868-qfdxri93	29	22	human	human	JJ
cord-288868-qfdxri93	29	23	infections	infection	NNS
cord-288868-qfdxri93	29	24	by	by	IN
cord-288868-qfdxri93	29	25	the	the	DT
cord-288868-qfdxri93	29	26	avian	avian	JJ
cord-288868-qfdxri93	29	27	H5N1	H5N1	NNP
cord-288868-qfdxri93	29	28	virus	virus	NN
cord-288868-qfdxri93	29	29	strain	strain	NN
cord-288868-qfdxri93	29	30	(	(	-LRB-
cord-288868-qfdxri93	29	31	where	where	WRB
cord-288868-qfdxri93	29	32	H	H	NNP
cord-288868-qfdxri93	29	33	stands	stand	VBZ
cord-288868-qfdxri93	29	34	for	for	IN
cord-288868-qfdxri93	29	35	hemagglutinin	hemagglutinin	NN
cord-288868-qfdxri93	29	36	and	and	CC
cord-288868-qfdxri93	29	37	N	n	CD
cord-288868-qfdxri93	29	38	for	for	IN
cord-288868-qfdxri93	29	39	neuraminidase	neuraminidase	NN
cord-288868-qfdxri93	29	40	,	,	,
cord-288868-qfdxri93	29	41	the	the	DT
cord-288868-qfdxri93	29	42	two	two	CD
cord-288868-qfdxri93	29	43	major	major	JJ
cord-288868-qfdxri93	29	44	surface	surface	NN
cord-288868-qfdxri93	29	45	glycoproteins	glycoprotein	NNS
cord-288868-qfdxri93	29	46	of	of	IN
cord-288868-qfdxri93	29	47	the	the	DT
cord-288868-qfdxri93	29	48	virus	virus	NN
cord-288868-qfdxri93	29	49	)	)	-RRB-
cord-288868-qfdxri93	29	50	in	in	IN
cord-288868-qfdxri93	29	51	2004	2004	CD
cord-288868-qfdxri93	29	52	,	,	,
cord-288868-qfdxri93	29	53	leading	lead	VBG
cord-288868-qfdxri93	29	54	to	to	IN
cord-288868-qfdxri93	29	55	52	52	CD
cord-288868-qfdxri93	29	56	deaths	death	NNS
cord-288868-qfdxri93	29	57	(	(	-LRB-
cord-288868-qfdxri93	29	58	http://www.who.int/csr/disease/avian	http://www.who.int/csr/disease/avian	NNP
cord-288868-qfdxri93	29	59	_	_	NNP
cord-288868-qfdxri93	29	60	influenza	influenza	NN
cord-288868-qfdxri93	29	61	/	/	SYM
cord-288868-qfdxri93	29	62	en/	en/	NNP
cord-288868-qfdxri93	29	63	)	)	-RRB-
cord-288868-qfdxri93	29	64	.	.	.
cord-288868-qfdxri93	30	1	This	this	DT
cord-288868-qfdxri93	30	2	was	be	VBD
cord-288868-qfdxri93	30	3	the	the	DT
cord-288868-qfdxri93	30	4	third	third	JJ
cord-288868-qfdxri93	30	5	time	time	NN
cord-288868-qfdxri93	30	6	in	in	IN
cord-288868-qfdxri93	30	7	the	the	DT
cord-288868-qfdxri93	30	8	space	space	NN
cord-288868-qfdxri93	30	9	of	of	IN
cord-288868-qfdxri93	30	10	a	a	DT
cord-288868-qfdxri93	30	11	few	few	JJ
cord-288868-qfdxri93	30	12	years	year	NNS
cord-288868-qfdxri93	30	13	(	(	-LRB-
cord-288868-qfdxri93	30	14	after	after	IN
cord-288868-qfdxri93	30	15	the	the	DT
cord-288868-qfdxri93	30	16	previous	previous	JJ
cord-288868-qfdxri93	30	17	outbreaks	outbreak	NNS
cord-288868-qfdxri93	30	18	of	of	IN
cord-288868-qfdxri93	30	19	infection	infection	NN
cord-288868-qfdxri93	30	20	in	in	IN
cord-288868-qfdxri93	30	21	1997	1997	CD
cord-288868-qfdxri93	30	22	and	and	CC
cord-288868-qfdxri93	30	23	2003	2003	CD
cord-288868-qfdxri93	30	24	)	)	-RRB-
cord-288868-qfdxri93	30	25	that	that	IN
cord-288868-qfdxri93	30	26	H5N1	H5N1	NNP
cord-288868-qfdxri93	30	27	avian	avian	JJ
cord-288868-qfdxri93	30	28	flu	flu	NN
cord-288868-qfdxri93	30	29	viruses	virus	NNS
cord-288868-qfdxri93	30	30	caused	cause	VBD
cord-288868-qfdxri93	30	31	disease	disease	NN
cord-288868-qfdxri93	30	32	and	and	CC
cord-288868-qfdxri93	30	33	death	death	NN
cord-288868-qfdxri93	30	34	in	in	IN
cord-288868-qfdxri93	30	35	humans	human	NNS
cord-288868-qfdxri93	30	36	.	.	.
cord-288868-qfdxri93	31	1	An	an	DT
cord-288868-qfdxri93	31	2	H9N2	H9N2	NNP
cord-288868-qfdxri93	31	3	avian	avian	JJ
cord-288868-qfdxri93	31	4	strain	strain	NN
cord-288868-qfdxri93	31	5	caused	cause	VBD
cord-288868-qfdxri93	31	6	infection	infection	NN
cord-288868-qfdxri93	31	7	in	in	IN
cord-288868-qfdxri93	31	8	humans	human	NNS
cord-288868-qfdxri93	31	9	in	in	IN
cord-288868-qfdxri93	31	10	1999	1999	CD
cord-288868-qfdxri93	31	11	and	and	CC
cord-288868-qfdxri93	31	12	2003	2003	CD
cord-288868-qfdxri93	31	13	.	.	.
cord-288868-qfdxri93	32	1	Because	because	IN
cord-288868-qfdxri93	32	2	the	the	DT
cord-288868-qfdxri93	32	3	world	world	NN
cord-288868-qfdxri93	32	4	's	's	POS
cord-288868-qfdxri93	32	5	population	population	NN
cord-288868-qfdxri93	32	6	has	have	VBZ
cord-288868-qfdxri93	32	7	not	not	RB
cord-288868-qfdxri93	32	8	been	be	VBN
cord-288868-qfdxri93	32	9	exposed	expose	VBN
cord-288868-qfdxri93	32	10	to	to	IN
cord-288868-qfdxri93	32	11	these	these	DT
cord-288868-qfdxri93	32	12	strains	strain	NNS
cord-288868-qfdxri93	32	13	,	,	,
cord-288868-qfdxri93	32	14	it	-PRON-	PRP
cord-288868-qfdxri93	32	15	is	be	VBZ
cord-288868-qfdxri93	32	16	immunologically	immunologically	RB
cord-288868-qfdxri93	32	17	naïve	naïve	JJ
cord-288868-qfdxri93	32	18	,	,	,
cord-288868-qfdxri93	32	19	and	and	CC
cord-288868-qfdxri93	32	20	these	these	DT
cord-288868-qfdxri93	32	21	or	or	CC
cord-288868-qfdxri93	32	22	any	any	DT
cord-288868-qfdxri93	32	23	other	other	JJ
cord-288868-qfdxri93	32	24	avian	avian	JJ
cord-288868-qfdxri93	32	25	flu	flu	NN
cord-288868-qfdxri93	32	26	strains	strain	NNS
cord-288868-qfdxri93	32	27	with	with	IN
cord-288868-qfdxri93	32	28	new	new	JJ
cord-288868-qfdxri93	32	29	surface	surface	NN
cord-288868-qfdxri93	32	30	glycoproteins	glycoprotein	NNS
cord-288868-qfdxri93	32	31	would	would	MD
cord-288868-qfdxri93	32	32	meet	meet	VB
cord-288868-qfdxri93	32	33	no	no	DT
cord-288868-qfdxri93	32	34	Possible	possible	JJ
cord-288868-qfdxri93	32	35	intervention	intervention	NN
cord-288868-qfdxri93	32	36	points	point	NNS
cord-288868-qfdxri93	32	37	for	for	IN
cord-288868-qfdxri93	32	38	vaccine	vaccine	NN
cord-288868-qfdxri93	32	39	improvement	improvement	NN
cord-288868-qfdxri93	32	40	.	.	.
cord-288868-qfdxri93	33	1	Schematic	schematic	JJ
cord-288868-qfdxri93	33	2	view	view	NN
cord-288868-qfdxri93	33	3	of	of	IN
cord-288868-qfdxri93	33	4	a	a	DT
cord-288868-qfdxri93	33	5	pathogen	pathogen	NN
cord-288868-qfdxri93	33	6	-	-	HYPH
cord-288868-qfdxri93	33	7	or	or	CC
cord-288868-qfdxri93	33	8	vaccine	vaccine	NN
cord-288868-qfdxri93	33	9	-	-	HYPH
cord-288868-qfdxri93	33	10	induced	induce	VBN
cord-288868-qfdxri93	33	11	immune	immune	JJ
cord-288868-qfdxri93	33	12	response	response	NN
cord-288868-qfdxri93	33	13	.	.	.
cord-288868-qfdxri93	34	1	Vaccines	vaccine	NNS
cord-288868-qfdxri93	34	2	or	or	CC
cord-288868-qfdxri93	34	3	pathogens	pathogen	NNS
cord-288868-qfdxri93	34	4	cross	cross	VBP
cord-288868-qfdxri93	34	5	epithelial	epithelial	JJ
cord-288868-qfdxri93	34	6	barriers	barrier	NNS
cord-288868-qfdxri93	34	7	and	and	CC
cord-288868-qfdxri93	34	8	are	be	VBP
cord-288868-qfdxri93	34	9	taken	take	VBN
cord-288868-qfdxri93	34	10	up	up	RP
cord-288868-qfdxri93	34	11	by	by	IN
cord-288868-qfdxri93	34	12	antigen	antigen	NN
cord-288868-qfdxri93	34	13	-	-	HYPH
cord-288868-qfdxri93	34	14	presenting	present	VBG
cord-288868-qfdxri93	34	15	cells	cell	NNS
cord-288868-qfdxri93	34	16	such	such	JJ
cord-288868-qfdxri93	34	17	as	as	IN
cord-288868-qfdxri93	34	18	DCs	DCs	NNP
cord-288868-qfdxri93	34	19	.	.	.
cord-288868-qfdxri93	35	1	Interaction	interaction	NN
cord-288868-qfdxri93	35	2	between	between	IN
cord-288868-qfdxri93	35	3	pattern	pattern	NN
cord-288868-qfdxri93	35	4	recognition	recognition	NN
cord-288868-qfdxri93	35	5	receptors	receptor	NNS
cord-288868-qfdxri93	35	6	(	(	-LRB-
cord-288868-qfdxri93	35	7	PRRs	PRRs	NNP
cord-288868-qfdxri93	35	8	)	)	-RRB-
cord-288868-qfdxri93	35	9	and	and	CC
cord-288868-qfdxri93	35	10	their	-PRON-	PRP$
cord-288868-qfdxri93	35	11	agonists	agonist	NNS
cord-288868-qfdxri93	35	12	activate	activate	VBP
cord-288868-qfdxri93	35	13	DCs	dc	NNS
cord-288868-qfdxri93	35	14	,	,	,
cord-288868-qfdxri93	35	15	resulting	result	VBG
cord-288868-qfdxri93	35	16	in	in	IN
cord-288868-qfdxri93	35	17	increased	increase	VBN
cord-288868-qfdxri93	35	18	antigen	antigen	NN
cord-288868-qfdxri93	35	19	presentation	presentation	NN
cord-288868-qfdxri93	35	20	,	,	,
cord-288868-qfdxri93	35	21	cytokine	cytokine	NN
cord-288868-qfdxri93	35	22	production	production	NN
cord-288868-qfdxri93	35	23	and	and	CC
cord-288868-qfdxri93	35	24	co	co	NN
cord-288868-qfdxri93	35	25	-	-	NN
cord-288868-qfdxri93	35	26	stimulation	stimulation	NN
cord-288868-qfdxri93	35	27	.	.	.
cord-288868-qfdxri93	36	1	CD4	CD4	NNP
cord-288868-qfdxri93	36	2	+	+	CC
cord-288868-qfdxri93	36	3	and	and	CC
cord-288868-qfdxri93	36	4	CD8	CD8	NNP
cord-288868-qfdxri93	36	5	+	+	CC
cord-288868-qfdxri93	36	6	T	T	NNP
cord-288868-qfdxri93	36	7	cells	cell	NNS
cord-288868-qfdxri93	36	8	recognize	recognize	VBP
cord-288868-qfdxri93	36	9	antigen	antigen	NN
cord-288868-qfdxri93	36	10	presented	present	VBN
cord-288868-qfdxri93	36	11	by	by	IN
cord-288868-qfdxri93	36	12	DCs	DCs	NNP
cord-288868-qfdxri93	36	13	and	and	CC
cord-288868-qfdxri93	36	14	are	be	VBP
cord-288868-qfdxri93	36	15	activated	activate	VBN
cord-288868-qfdxri93	36	16	.	.	.
cord-288868-qfdxri93	37	1	Cognate	cognate	JJ
cord-288868-qfdxri93	37	2	interaction	interaction	NN
cord-288868-qfdxri93	37	3	between	between	IN
cord-288868-qfdxri93	37	4	primed	primed	JJ
cord-288868-qfdxri93	37	5	CD4	CD4	NNP
cord-288868-qfdxri93	37	6	+	+	CC
cord-288868-qfdxri93	37	7	T	t	NN
cord-288868-qfdxri93	37	8	cells	cell	NNS
cord-288868-qfdxri93	37	9	and	and	CC
cord-288868-qfdxri93	37	10	B	b	NN
cord-288868-qfdxri93	37	11	cells	cell	NNS
cord-288868-qfdxri93	37	12	activates	activate	VBZ
cord-288868-qfdxri93	37	13	the	the	DT
cord-288868-qfdxri93	37	14	B	b	NN
cord-288868-qfdxri93	37	15	cells	cell	NNS
cord-288868-qfdxri93	37	16	,	,	,
cord-288868-qfdxri93	37	17	resulting	result	VBG
cord-288868-qfdxri93	37	18	in	in	IN
cord-288868-qfdxri93	37	19	clonal	clonal	JJ
cord-288868-qfdxri93	37	20	expansion	expansion	NN
cord-288868-qfdxri93	37	21	and	and	CC
cord-288868-qfdxri93	37	22	antibody	antibody	NN
cord-288868-qfdxri93	37	23	production	production	NN
cord-288868-qfdxri93	37	24	.	.	.
cord-288868-qfdxri93	38	1	DC	DC	NNP
cord-288868-qfdxri93	38	2	activation	activation	NN
cord-288868-qfdxri93	38	3	also	also	RB
cord-288868-qfdxri93	38	4	leads	lead	VBZ
cord-288868-qfdxri93	38	5	to	to	IN
cord-288868-qfdxri93	38	6	inhibition	inhibition	NN
cord-288868-qfdxri93	38	7	of	of	IN
cord-288868-qfdxri93	38	8	the	the	DT
cord-288868-qfdxri93	38	9	regulatory	regulatory	JJ
cord-288868-qfdxri93	38	10	effect	effect	NN
cord-288868-qfdxri93	38	11	of	of	IN
cord-288868-qfdxri93	38	12	CD4	CD4	NNP
cord-288868-qfdxri93	38	13	+	+	CC
cord-288868-qfdxri93	38	14	CD25	CD25	NNP
cord-288868-qfdxri93	38	15	+	+	CC
cord-288868-qfdxri93	38	16	Treg	Treg	NNP
cord-288868-qfdxri93	38	17	cells	cell	NNS
cord-288868-qfdxri93	38	18	.	.	.
cord-288868-qfdxri93	39	1	Fully	fully	RB
cord-288868-qfdxri93	39	2	activated	activate	VBN
cord-288868-qfdxri93	39	3	CD8	CD8	NNP
cord-288868-qfdxri93	39	4	+	+	CC
cord-288868-qfdxri93	39	5	cells	cell	NNS
cord-288868-qfdxri93	39	6	can	can	MD
cord-288868-qfdxri93	39	7	target	target	VB
cord-288868-qfdxri93	39	8	tumor	tumor	NN
cord-288868-qfdxri93	39	9	cells	cell	NNS
cord-288868-qfdxri93	39	10	and	and	CC
cord-288868-qfdxri93	39	11	pathogen	pathogen	NN
cord-288868-qfdxri93	39	12	-	-	HYPH
cord-288868-qfdxri93	39	13	infected	infect	VBN
cord-288868-qfdxri93	39	14	cells	cell	NNS
cord-288868-qfdxri93	39	15	.	.	.
cord-288868-qfdxri93	40	1	The	the	DT
cord-288868-qfdxri93	40	2	letters	letter	NNS
cord-288868-qfdxri93	40	3	(	(	-LRB-
cord-288868-qfdxri93	40	4	a	a	LS
cord-288868-qfdxri93	40	5	-	-	:
cord-288868-qfdxri93	40	6	i	i	JJ
cord-288868-qfdxri93	40	7	)	)	-RRB-
cord-288868-qfdxri93	40	8	indicate	indicate	VBP
cord-288868-qfdxri93	40	9	processes	process	NNS
cord-288868-qfdxri93	40	10	where	where	WRB
cord-288868-qfdxri93	40	11	improved	improve	VBN
cord-288868-qfdxri93	40	12	vaccines	vaccine	NNS
cord-288868-qfdxri93	40	13	can	can	MD
cord-288868-qfdxri93	40	14	lead	lead	VB
cord-288868-qfdxri93	40	15	to	to	IN
cord-288868-qfdxri93	40	16	more	more	RBR
cord-288868-qfdxri93	40	17	efficient	efficient	JJ
cord-288868-qfdxri93	40	18	immune	immune	JJ
cord-288868-qfdxri93	40	19	responses	response	NNS
cord-288868-qfdxri93	40	20	:	:	:
cord-288868-qfdxri93	40	21	(	(	-LRB-
cord-288868-qfdxri93	40	22	a	a	LS
cord-288868-qfdxri93	40	23	)	)	-RRB-
cord-288868-qfdxri93	41	1	The	the	DT
cord-288868-qfdxri93	41	2	site	site	NN
cord-288868-qfdxri93	41	3	of	of	IN
cord-288868-qfdxri93	41	4	administration	administration	NN
cord-288868-qfdxri93	41	5	influences	influence	VBZ
cord-288868-qfdxri93	41	6	the	the	DT
cord-288868-qfdxri93	41	7	type	type	NN
cord-288868-qfdxri93	41	8	of	of	IN
cord-288868-qfdxri93	41	9	immune	immune	JJ
cord-288868-qfdxri93	41	10	response	response	NN
cord-288868-qfdxri93	41	11	and	and	CC
cord-288868-qfdxri93	41	12	enables	enable	VBZ
cord-288868-qfdxri93	41	13	the	the	DT
cord-288868-qfdxri93	41	14	usage	usage	NN
cord-288868-qfdxri93	41	15	of	of	IN
cord-288868-qfdxri93	41	16	lower	low	JJR
cord-288868-qfdxri93	41	17	vaccine	vaccine	NN
cord-288868-qfdxri93	41	18	doses	dose	NNS
cord-288868-qfdxri93	41	19	[	[	-LRB-
cord-288868-qfdxri93	41	20	19	19	CD
cord-288868-qfdxri93	41	21	,	,	,
cord-288868-qfdxri93	41	22	20	20	CD
cord-288868-qfdxri93	41	23	]	]	-RRB-
cord-288868-qfdxri93	41	24	.	.	.
cord-288868-qfdxri93	42	1	(	(	-LRB-
cord-288868-qfdxri93	42	2	b	b	LS
cord-288868-qfdxri93	42	3	)	)	-RRB-
cord-288868-qfdxri93	42	4	Particulate	particulate	NN
cord-288868-qfdxri93	42	5	antigen	antigen	NN
cord-288868-qfdxri93	42	6	is	be	VBZ
cord-288868-qfdxri93	42	7	taken	take	VBN
cord-288868-qfdxri93	42	8	up	up	RP
cord-288868-qfdxri93	42	9	more	more	RBR
cord-288868-qfdxri93	42	10	easily	easily	RB
cord-288868-qfdxri93	42	11	by	by	IN
cord-288868-qfdxri93	42	12	macrophages	macrophage	NNS
cord-288868-qfdxri93	42	13	and	and	CC
cord-288868-qfdxri93	42	14	DCs	dc	NNS
cord-288868-qfdxri93	42	15	than	than	IN
cord-288868-qfdxri93	42	16	soluble	soluble	JJ
cord-288868-qfdxri93	42	17	antigen	antigen	NN
cord-288868-qfdxri93	42	18	[	[	-LRB-
cord-288868-qfdxri93	42	19	47	47	CD
cord-288868-qfdxri93	42	20	]	]	-RRB-
cord-288868-qfdxri93	42	21	.	.	.
cord-288868-qfdxri93	43	1	(	(	-LRB-
cord-288868-qfdxri93	43	2	c	c	NN
cord-288868-qfdxri93	43	3	)	)	-RRB-
cord-288868-qfdxri93	43	4	TLR	TLR	NNP
cord-288868-qfdxri93	43	5	agonists	agonist	NNS
cord-288868-qfdxri93	43	6	and	and	CC
cord-288868-qfdxri93	43	7	other	other	JJ
cord-288868-qfdxri93	43	8	immunostimulants	immunostimulant	NNS
cord-288868-qfdxri93	43	9	binding	bind	VBG
cord-288868-qfdxri93	43	10	to	to	IN
cord-288868-qfdxri93	43	11	PRRs	prr	NNS
cord-288868-qfdxri93	43	12	increase	increase	VB
cord-288868-qfdxri93	43	13	the	the	DT
cord-288868-qfdxri93	43	14	activation	activation	NN
cord-288868-qfdxri93	43	15	of	of	IN
cord-288868-qfdxri93	43	16	DCs	DCs	NNP
cord-288868-qfdxri93	43	17	[	[	-LRB-
cord-288868-qfdxri93	43	18	32	32	CD
cord-288868-qfdxri93	43	19	-	-	SYM
cord-288868-qfdxri93	43	20	35,36	35,36	CD
cord-288868-qfdxri93	43	21	,	,	,
cord-288868-qfdxri93	43	22	37	37	CD
cord-288868-qfdxri93	43	23	,	,	,
cord-288868-qfdxri93	43	24	38,40	38,40	CD
cord-288868-qfdxri93	43	25	]	]	-RRB-
cord-288868-qfdxri93	43	26	.	.	.
cord-288868-qfdxri93	44	1	(	(	-LRB-
cord-288868-qfdxri93	44	2	d	d	LS
cord-288868-qfdxri93	44	3	)	)	-RRB-
cord-288868-qfdxri93	44	4	DCs	DCs	NNP
cord-288868-qfdxri93	44	5	matured	mature	VBD
cord-288868-qfdxri93	44	6	and	and	CC
cord-288868-qfdxri93	44	7	loaded	load	VBN
cord-288868-qfdxri93	44	8	with	with	IN
cord-288868-qfdxri93	44	9	antigen	antigen	NN
cord-288868-qfdxri93	44	10	in	in	IN
cord-288868-qfdxri93	44	11	vitro	vitro	FW
cord-288868-qfdxri93	44	12	are	be	VBP
cord-288868-qfdxri93	44	13	efficient	efficient	JJ
cord-288868-qfdxri93	44	14	vaccines	vaccine	NNS
cord-288868-qfdxri93	44	15	[	[	-LRB-
cord-288868-qfdxri93	44	16	41	41	CD
cord-288868-qfdxri93	44	17	,	,	,
cord-288868-qfdxri93	44	18	42,43	42,43	CD
cord-288868-qfdxri93	44	19	]	]	-RRB-
cord-288868-qfdxri93	44	20	.	.	.
cord-288868-qfdxri93	45	1	(	(	-LRB-
cord-288868-qfdxri93	45	2	e	e	LS
cord-288868-qfdxri93	45	3	)	)	-RRB-
cord-288868-qfdxri93	45	4	DNA	dna	NN
cord-288868-qfdxri93	45	5	vaccination	vaccination	NN
cord-288868-qfdxri93	45	6	leads	lead	VBZ
cord-288868-qfdxri93	45	7	to	to	IN
cord-288868-qfdxri93	45	8	efficient	efficient	JJ
cord-288868-qfdxri93	45	9	antigen	antigen	NN
cord-288868-qfdxri93	45	10	presentation	presentation	NN
cord-288868-qfdxri93	45	11	on	on	IN
cord-288868-qfdxri93	45	12	MHC	MHC	NNP
cord-288868-qfdxri93	45	13	class	class	NN
cord-288868-qfdxri93	46	1	I	-PRON-	PRP
cord-288868-qfdxri93	46	2	[	[	-LRB-
cord-288868-qfdxri93	46	3	48,49,50	48,49,50	CD
cord-288868-qfdxri93	46	4	,	,	,
cord-288868-qfdxri93	46	5	51	51	CD
cord-288868-qfdxri93	46	6	,	,	,
cord-288868-qfdxri93	46	7	52,53	52,53	CD
cord-288868-qfdxri93	46	8	]	]	-RRB-
cord-288868-qfdxri93	46	9	.	.	.
cord-288868-qfdxri93	47	1	Crosspresentation	crosspresentation	NN
cord-288868-qfdxri93	47	2	of	of	IN
cord-288868-qfdxri93	47	3	antigen	antigen	NN
cord-288868-qfdxri93	47	4	on	on	IN
cord-288868-qfdxri93	47	5	MHC	MHC	NNP
cord-288868-qfdxri93	47	6	class	class	NN
cord-288868-qfdxri93	47	7	I	-PRON-	PRP
cord-288868-qfdxri93	47	8	of	of	IN
cord-288868-qfdxri93	47	9	host	host	NN
cord-288868-qfdxri93	47	10	DCs	DCs	NNP
cord-288868-qfdxri93	47	11	is	be	VBZ
cord-288868-qfdxri93	47	12	facilitated	facilitate	VBN
cord-288868-qfdxri93	47	13	after	after	IN
cord-288868-qfdxri93	47	14	vaccination	vaccination	NN
cord-288868-qfdxri93	47	15	with	with	IN
cord-288868-qfdxri93	47	16	antigen	antigen	NN
cord-288868-qfdxri93	47	17	-	-	HYPH
cord-288868-qfdxri93	47	18	loaded	load	VBN
cord-288868-qfdxri93	47	19	DCs	dc	NNS
cord-288868-qfdxri93	47	20	undergoing	undergo	VBG
cord-288868-qfdxri93	47	21	delayed	delay	VBN
cord-288868-qfdxri93	47	22	apoptosis	apoptosis	NN
cord-288868-qfdxri93	47	23	[	[	-LRB-
cord-288868-qfdxri93	47	24	44	44	CD
cord-288868-qfdxri93	47	25	]	]	-RRB-
cord-288868-qfdxri93	47	26	.	.	.
cord-288868-qfdxri93	48	1	(	(	-LRB-
cord-288868-qfdxri93	48	2	f	f	LS
cord-288868-qfdxri93	48	3	)	)	-RRB-
cord-288868-qfdxri93	48	4	Cytokines	Cytokines	NNP
cord-288868-qfdxri93	48	5	can	can	MD
cord-288868-qfdxri93	48	6	be	be	VB
cord-288868-qfdxri93	48	7	added	add	VBN
cord-288868-qfdxri93	48	8	in	in	IN
cord-288868-qfdxri93	48	9	protein	protein	NN
cord-288868-qfdxri93	48	10	or	or	CC
cord-288868-qfdxri93	48	11	DNA	dna	NN
cord-288868-qfdxri93	48	12	form	form	NN
cord-288868-qfdxri93	48	13	as	as	IN
cord-288868-qfdxri93	48	14	natural	natural	JJ
cord-288868-qfdxri93	48	15	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	48	16	[	[	-LRB-
cord-288868-qfdxri93	48	17	32	32	CD
cord-288868-qfdxri93	48	18	,	,	,
cord-288868-qfdxri93	48	19	33	33	CD
cord-288868-qfdxri93	48	20	]	]	-RRB-
cord-288868-qfdxri93	48	21	.	.	.
cord-288868-qfdxri93	49	1	(	(	-LRB-
cord-288868-qfdxri93	49	2	g	g	NN
cord-288868-qfdxri93	49	3	)	)	-RRB-
cord-288868-qfdxri93	49	4	Recruited	recruit	VBN
cord-288868-qfdxri93	49	5	NK	NK	NNP
cord-288868-qfdxri93	49	6	cells	cell	NNS
cord-288868-qfdxri93	49	7	can	can	MD
cord-288868-qfdxri93	49	8	be	be	VB
cord-288868-qfdxri93	49	9	an	an	DT
cord-288868-qfdxri93	49	10	early	early	JJ
cord-288868-qfdxri93	49	11	source	source	NN
cord-288868-qfdxri93	49	12	of	of	IN
cord-288868-qfdxri93	49	13	Th1-driving	Th1-driving	NNP
cord-288868-qfdxri93	49	14	cytokines	cytokine	NNS
cord-288868-qfdxri93	49	15	[	[	-LRB-
cord-288868-qfdxri93	49	16	39	39	CD
cord-288868-qfdxri93	49	17	]	]	-RRB-
cord-288868-qfdxri93	49	18	.	.	.
cord-288868-qfdxri93	50	1	(	(	-LRB-
cord-288868-qfdxri93	50	2	h	h	NN
cord-288868-qfdxri93	50	3	)	)	-RRB-
cord-288868-qfdxri93	51	1	Vaccines	vaccine	NNS
cord-288868-qfdxri93	51	2	can	can	MD
cord-288868-qfdxri93	51	3	break	break	VB
cord-288868-qfdxri93	51	4	tolerance	tolerance	NN
cord-288868-qfdxri93	51	5	when	when	WRB
cord-288868-qfdxri93	51	6	the	the	DT
cord-288868-qfdxri93	51	7	suppressive	suppressive	JJ
cord-288868-qfdxri93	51	8	effect	effect	NN
cord-288868-qfdxri93	51	9	of	of	IN
cord-288868-qfdxri93	51	10	CD4	CD4	NNP
cord-288868-qfdxri93	51	11	+	+	CC
cord-288868-qfdxri93	51	12	CD25	CD25	NNP
cord-288868-qfdxri93	51	13	+	+	CC
cord-288868-qfdxri93	51	14	Treg	Treg	NNP
cord-288868-qfdxri93	51	15	cells	cell	NNS
cord-288868-qfdxri93	51	16	is	be	VBZ
cord-288868-qfdxri93	51	17	overcome	overcome	VBN
cord-288868-qfdxri93	51	18	[	[	-LRB-
cord-288868-qfdxri93	51	19	54	54	CD
cord-288868-qfdxri93	51	20	]	]	-RRB-
cord-288868-qfdxri93	51	21	.	.	.
cord-288868-qfdxri93	52	1	resistance	resistance	NN
cord-288868-qfdxri93	52	2	provided	provide	VBN
cord-288868-qfdxri93	52	3	by	by	IN
cord-288868-qfdxri93	52	4	existing	exist	VBG
cord-288868-qfdxri93	52	5	immunity	immunity	NN
cord-288868-qfdxri93	52	6	and	and	CC
cord-288868-qfdxri93	52	7	could	could	MD
cord-288868-qfdxri93	52	8	rapidly	rapidly	RB
cord-288868-qfdxri93	52	9	expand	expand	VB
cord-288868-qfdxri93	52	10	.	.	.
cord-288868-qfdxri93	53	1	Once	once	RB
cord-288868-qfdxri93	53	2	an	an	DT
cord-288868-qfdxri93	53	3	avian	avian	JJ
cord-288868-qfdxri93	53	4	strain	strain	NN
cord-288868-qfdxri93	53	5	has	have	VBZ
cord-288868-qfdxri93	53	6	developed	develop	VBN
cord-288868-qfdxri93	53	7	a	a	DT
cord-288868-qfdxri93	53	8	more	more	RBR
cord-288868-qfdxri93	53	9	efficient	efficient	JJ
cord-288868-qfdxri93	53	10	means	mean	NNS
cord-288868-qfdxri93	53	11	of	of	IN
cord-288868-qfdxri93	53	12	human	human	NN
cord-288868-qfdxri93	53	13	-	-	HYPH
cord-288868-qfdxri93	53	14	to	to	IN
cord-288868-qfdxri93	53	15	-	-	HYPH
cord-288868-qfdxri93	53	16	human	human	JJ
cord-288868-qfdxri93	53	17	transmission	transmission	NN
cord-288868-qfdxri93	53	18	,	,	,
cord-288868-qfdxri93	53	19	devastating	devastating	JJ
cord-288868-qfdxri93	53	20	pandemics	pandemic	NNS
cord-288868-qfdxri93	53	21	,	,	,
cord-288868-qfdxri93	53	22	such	such	JJ
cord-288868-qfdxri93	53	23	as	as	IN
cord-288868-qfdxri93	53	24	those	those	DT
cord-288868-qfdxri93	53	25	arising	arise	VBG
cord-288868-qfdxri93	53	26	in	in	IN
cord-288868-qfdxri93	53	27	1918	1918	CD
cord-288868-qfdxri93	53	28	,	,	,
cord-288868-qfdxri93	53	29	1957	1957	CD
cord-288868-qfdxri93	53	30	and	and	CC
cord-288868-qfdxri93	53	31	1968	1968	CD
cord-288868-qfdxri93	53	32	,	,	,
cord-288868-qfdxri93	53	33	could	could	MD
cord-288868-qfdxri93	53	34	ensue	ensue	VB
cord-288868-qfdxri93	53	35	.	.	.
cord-288868-qfdxri93	54	1	It	-PRON-	PRP
cord-288868-qfdxri93	54	2	should	should	MD
cord-288868-qfdxri93	54	3	be	be	VB
cord-288868-qfdxri93	54	4	noted	note	VBN
cord-288868-qfdxri93	54	5	,	,	,
cord-288868-qfdxri93	54	6	however	however	RB
cord-288868-qfdxri93	54	7	,	,	,
cord-288868-qfdxri93	54	8	that	that	IN
cord-288868-qfdxri93	54	9	older	old	JJR
cord-288868-qfdxri93	54	10	studies	study	NNS
cord-288868-qfdxri93	54	11	found	find	VBD
cord-288868-qfdxri93	54	12	seroprevalence	seroprevalence	NN
cord-288868-qfdxri93	54	13	rates	rate	NNS
cord-288868-qfdxri93	54	14	for	for	IN
cord-288868-qfdxri93	54	15	avian	avian	JJ
cord-288868-qfdxri93	54	16	flu	flu	NN
cord-288868-qfdxri93	54	17	strains	strain	NNS
cord-288868-qfdxri93	54	18	among	among	IN
cord-288868-qfdxri93	54	19	Chinese	chinese	JJ
cord-288868-qfdxri93	54	20	rural	rural	JJ
cord-288868-qfdxri93	54	21	populations	population	NNS
cord-288868-qfdxri93	54	22	to	to	TO
cord-288868-qfdxri93	54	23	be	be	VB
cord-288868-qfdxri93	54	24	between	between	IN
cord-288868-qfdxri93	54	25	2	2	CD
cord-288868-qfdxri93	54	26	%	%	NN
cord-288868-qfdxri93	54	27	and	and	CC
cord-288868-qfdxri93	54	28	7	7	CD
cord-288868-qfdxri93	54	29	%	%	NN
cord-288868-qfdxri93	54	30	for	for	IN
cord-288868-qfdxri93	54	31	H5	h5	NN
cord-288868-qfdxri93	54	32	viruses	virus	NNS
cord-288868-qfdxri93	54	33	and	and	CC
cord-288868-qfdxri93	54	34	between	between	IN
cord-288868-qfdxri93	54	35	15	15	CD
cord-288868-qfdxri93	54	36	%	%	NN
cord-288868-qfdxri93	54	37	and	and	CC
cord-288868-qfdxri93	54	38	38	38	CD
cord-288868-qfdxri93	54	39	%	%	NN
cord-288868-qfdxri93	54	40	for	for	IN
cord-288868-qfdxri93	54	41	other	other	JJ
cord-288868-qfdxri93	54	42	avian	avian	JJ
cord-288868-qfdxri93	54	43	strains	strain	NNS
cord-288868-qfdxri93	54	44	[	[	-LRB-
cord-288868-qfdxri93	54	45	6	6	CD
cord-288868-qfdxri93	54	46	,	,	,
cord-288868-qfdxri93	54	47	7	7	CD
cord-288868-qfdxri93	54	48	]	]	-RRB-
cord-288868-qfdxri93	54	49	.	.	.
cord-288868-qfdxri93	55	1	Thus	thus	RB
cord-288868-qfdxri93	55	2	,	,	,
cord-288868-qfdxri93	55	3	it	-PRON-	PRP
cord-288868-qfdxri93	55	4	might	may	MD
cord-288868-qfdxri93	55	5	in	in	IN
cord-288868-qfdxri93	55	6	fact	fact	NN
cord-288868-qfdxri93	55	7	be	be	VB
cord-288868-qfdxri93	55	8	the	the	DT
cord-288868-qfdxri93	55	9	quality	quality	NN
cord-288868-qfdxri93	55	10	of	of	IN
cord-288868-qfdxri93	55	11	surveillance	surveillance	NN
cord-288868-qfdxri93	55	12	,	,	,
cord-288868-qfdxri93	55	13	rather	rather	RB
cord-288868-qfdxri93	55	14	than	than	IN
cord-288868-qfdxri93	55	15	the	the	DT
cord-288868-qfdxri93	55	16	frequency	frequency	NN
cord-288868-qfdxri93	55	17	of	of	IN
cord-288868-qfdxri93	55	18	outbreaks	outbreak	NNS
cord-288868-qfdxri93	55	19	,	,	,
cord-288868-qfdxri93	55	20	that	that	WDT
cord-288868-qfdxri93	55	21	has	have	VBZ
cord-288868-qfdxri93	55	22	increased	increase	VBN
cord-288868-qfdxri93	55	23	over	over	IN
cord-288868-qfdxri93	55	24	the	the	DT
cord-288868-qfdxri93	55	25	past	past	JJ
cord-288868-qfdxri93	55	26	few	few	JJ
cord-288868-qfdxri93	55	27	years	year	NNS
cord-288868-qfdxri93	55	28	[	[	-LRB-
cord-288868-qfdxri93	55	29	8	8	CD
cord-288868-qfdxri93	55	30	]	]	-RRB-
cord-288868-qfdxri93	55	31	.	.	.
cord-288868-qfdxri93	56	1	However	however	RB
cord-288868-qfdxri93	56	2	,	,	,
cord-288868-qfdxri93	56	3	the	the	DT
cord-288868-qfdxri93	56	4	contact	contact	NN
cord-288868-qfdxri93	56	5	between	between	IN
cord-288868-qfdxri93	56	6	humans	human	NNS
cord-288868-qfdxri93	56	7	and	and	CC
cord-288868-qfdxri93	56	8	pathogens	pathogen	NNS
cord-288868-qfdxri93	56	9	in	in	IN
cord-288868-qfdxri93	56	10	animal	animal	NN
cord-288868-qfdxri93	56	11	reservoirs	reservoir	NNS
cord-288868-qfdxri93	56	12	is	be	VBZ
cord-288868-qfdxri93	56	13	likely	likely	JJ
cord-288868-qfdxri93	56	14	to	to	TO
cord-288868-qfdxri93	56	15	intensify	intensify	VB
cord-288868-qfdxri93	56	16	,	,	,
cord-288868-qfdxri93	56	17	and	and	CC
cord-288868-qfdxri93	56	18	,	,	,
cord-288868-qfdxri93	56	19	consequently	consequently	RB
cord-288868-qfdxri93	56	20	,	,	,
cord-288868-qfdxri93	56	21	the	the	DT
cord-288868-qfdxri93	56	22	emergence	emergence	NN
cord-288868-qfdxri93	56	23	or	or	CC
cord-288868-qfdxri93	56	24	re	re	NN
cord-288868-qfdxri93	56	25	-	-	NN
cord-288868-qfdxri93	56	26	emergence	emergence	NN
cord-288868-qfdxri93	56	27	of	of	IN
cord-288868-qfdxri93	56	28	diseases	disease	NNS
cord-288868-qfdxri93	56	29	will	will	MD
cord-288868-qfdxri93	56	30	occupy	occupy	VB
cord-288868-qfdxri93	56	31	vaccinologists	vaccinologist	NNS
cord-288868-qfdxri93	56	32	frequently	frequently	RB
cord-288868-qfdxri93	56	33	in	in	IN
cord-288868-qfdxri93	56	34	the	the	DT
cord-288868-qfdxri93	56	35	future	future	NN
cord-288868-qfdxri93	56	36	.	.	.
cord-288868-qfdxri93	57	1	One	one	CD
cord-288868-qfdxri93	57	2	of	of	IN
cord-288868-qfdxri93	57	3	the	the	DT
cord-288868-qfdxri93	57	4	most	most	RBS
cord-288868-qfdxri93	57	5	important	important	JJ
cord-288868-qfdxri93	57	6	future	future	JJ
cord-288868-qfdxri93	57	7	challenges	challenge	NNS
cord-288868-qfdxri93	57	8	will	will	MD
cord-288868-qfdxri93	57	9	be	be	VB
cord-288868-qfdxri93	57	10	to	to	TO
cord-288868-qfdxri93	57	11	respond	respond	VB
cord-288868-qfdxri93	57	12	promptly	promptly	RB
cord-288868-qfdxri93	57	13	to	to	IN
cord-288868-qfdxri93	57	14	emerging	emerge	VBG
cord-288868-qfdxri93	57	15	diseases	disease	NNS
cord-288868-qfdxri93	57	16	such	such	JJ
cord-288868-qfdxri93	57	17	as	as	IN
cord-288868-qfdxri93	57	18	those	those	DT
cord-288868-qfdxri93	57	19	mentioned	mention	VBN
cord-288868-qfdxri93	57	20	above	above	RB
cord-288868-qfdxri93	57	21	.	.	.
cord-288868-qfdxri93	58	1	A	a	DT
cord-288868-qfdxri93	58	2	striking	striking	JJ
cord-288868-qfdxri93	58	3	example	example	NN
cord-288868-qfdxri93	58	4	for	for	IN
cord-288868-qfdxri93	58	5	rapid	rapid	JJ
cord-288868-qfdxri93	58	6	reaction	reaction	NN
cord-288868-qfdxri93	58	7	was	be	VBD
cord-288868-qfdxri93	58	8	in	in	IN
cord-288868-qfdxri93	58	9	the	the	DT
cord-288868-qfdxri93	58	10	case	case	NN
cord-288868-qfdxri93	58	11	of	of	IN
cord-288868-qfdxri93	58	12	the	the	DT
cord-288868-qfdxri93	58	13	SARS	SARS	NNP
cord-288868-qfdxri93	58	14	outbreak	outbreak	NN
cord-288868-qfdxri93	58	15	,	,	,
cord-288868-qfdxri93	58	16	where	where	WRB
cord-288868-qfdxri93	58	17	the	the	DT
cord-288868-qfdxri93	58	18	genome	genome	NN
cord-288868-qfdxri93	58	19	sequence	sequence	NN
cord-288868-qfdxri93	58	20	was	be	VBD
cord-288868-qfdxri93	58	21	publicly	publicly	RB
cord-288868-qfdxri93	58	22	available	available	JJ
cord-288868-qfdxri93	58	23	in	in	IN
cord-288868-qfdxri93	58	24	less	less	JJR
cord-288868-qfdxri93	58	25	than	than	IN
cord-288868-qfdxri93	58	26	a	a	DT
cord-288868-qfdxri93	58	27	month	month	NN
cord-288868-qfdxri93	58	28	after	after	IN
cord-288868-qfdxri93	58	29	the	the	DT
cord-288868-qfdxri93	58	30	virus	virus	NN
cord-288868-qfdxri93	58	31	was	be	VBD
cord-288868-qfdxri93	58	32	identified	identify	VBN
cord-288868-qfdxri93	58	33	[	[	-LRB-
cord-288868-qfdxri93	58	34	9	9	CD
cord-288868-qfdxri93	58	35	]	]	-RRB-
cord-288868-qfdxri93	58	36	.	.	.
cord-288868-qfdxri93	59	1	This	this	DT
cord-288868-qfdxri93	59	2	enabled	enable	VBD
cord-288868-qfdxri93	59	3	the	the	DT
cord-288868-qfdxri93	59	4	speedy	speedy	JJ
cord-288868-qfdxri93	59	5	development	development	NN
cord-288868-qfdxri93	59	6	of	of	IN
cord-288868-qfdxri93	59	7	diagnostic	diagnostic	JJ
cord-288868-qfdxri93	59	8	tools	tool	NNS
cord-288868-qfdxri93	59	9	,	,	,
cord-288868-qfdxri93	59	10	as	as	RB
cord-288868-qfdxri93	59	11	well	well	RB
cord-288868-qfdxri93	59	12	as	as	IN
cord-288868-qfdxri93	59	13	the	the	DT
cord-288868-qfdxri93	59	14	identification	identification	NN
cord-288868-qfdxri93	59	15	and	and	CC
cord-288868-qfdxri93	59	16	recombinant	recombinant	JJ
cord-288868-qfdxri93	59	17	expression	expression	NN
cord-288868-qfdxri93	59	18	of	of	IN
cord-288868-qfdxri93	59	19	targets	target	NNS
cord-288868-qfdxri93	59	20	for	for	IN
cord-288868-qfdxri93	59	21	vaccines	vaccine	NNS
cord-288868-qfdxri93	59	22	and	and	CC
cord-288868-qfdxri93	59	23	therapeutic	therapeutic	JJ
cord-288868-qfdxri93	59	24	agents	agent	NNS
cord-288868-qfdxri93	59	25	[	[	-LRB-
cord-288868-qfdxri93	59	26	10	10	CD
cord-288868-qfdxri93	59	27	]	]	-RRB-
cord-288868-qfdxri93	59	28	[	[	-LRB-
cord-288868-qfdxri93	59	29	11	11	CD
cord-288868-qfdxri93	59	30	]	]	-RRB-
cord-288868-qfdxri93	59	31	[	[	-LRB-
cord-288868-qfdxri93	59	32	12	12	CD
cord-288868-qfdxri93	59	33	]	]	-RRB-
cord-288868-qfdxri93	59	34	.	.	.
cord-288868-qfdxri93	60	1	For	for	IN
cord-288868-qfdxri93	60	2	the	the	DT
cord-288868-qfdxri93	60	3	influenza	influenza	NN
cord-288868-qfdxri93	60	4	virus	virus	NN
cord-288868-qfdxri93	60	5	,	,	,
cord-288868-qfdxri93	60	6	in	in	IN
cord-288868-qfdxri93	60	7	addition	addition	NN
cord-288868-qfdxri93	60	8	to	to	IN
cord-288868-qfdxri93	60	9	the	the	DT
cord-288868-qfdxri93	60	10	annual	annual	JJ
cord-288868-qfdxri93	60	11	definition	definition	NN
cord-288868-qfdxri93	60	12	of	of	IN
cord-288868-qfdxri93	60	13	the	the	DT
cord-288868-qfdxri93	60	14	relevant	relevant	JJ
cord-288868-qfdxri93	60	15	strains	strain	NNS
cord-288868-qfdxri93	60	16	to	to	TO
cord-288868-qfdxri93	60	17	be	be	VB
cord-288868-qfdxri93	60	18	included	include	VBN
cord-288868-qfdxri93	60	19	in	in	IN
cord-288868-qfdxri93	60	20	the	the	DT
cord-288868-qfdxri93	60	21	vaccine	vaccine	NN
cord-288868-qfdxri93	60	22	for	for	IN
cord-288868-qfdxri93	60	23	the	the	DT
cord-288868-qfdxri93	60	24	following	follow	VBG
cord-288868-qfdxri93	60	25	season	season	NN
cord-288868-qfdxri93	60	26	,	,	,
cord-288868-qfdxri93	60	27	the	the	DT
cord-288868-qfdxri93	60	28	World	World	NNP
cord-288868-qfdxri93	60	29	Health	Health	NNP
cord-288868-qfdxri93	60	30	Organization	Organization	NNP
cord-288868-qfdxri93	60	31	closely	closely	RB
cord-288868-qfdxri93	60	32	monitors	monitor	VBZ
cord-288868-qfdxri93	60	33	cases	case	NNS
cord-288868-qfdxri93	60	34	of	of	IN
cord-288868-qfdxri93	60	35	avian	avian	JJ
cord-288868-qfdxri93	60	36	flu	flu	NN
cord-288868-qfdxri93	60	37	(	(	-LRB-
cord-288868-qfdxri93	60	38	for	for	IN
cord-288868-qfdxri93	60	39	further	further	JJ
cord-288868-qfdxri93	60	40	information	information	NN
cord-288868-qfdxri93	60	41	,	,	,
cord-288868-qfdxri93	60	42	see	see	VB
cord-288868-qfdxri93	60	43	the	the	DT
cord-288868-qfdxri93	60	44	World	World	NNP
cord-288868-qfdxri93	60	45	Health	Health	NNP
cord-288868-qfdxri93	60	46	Organization	Organization	NNP
cord-288868-qfdxri93	60	47	website	website	NN
cord-288868-qfdxri93	60	48	indicated	indicate	VBD
cord-288868-qfdxri93	60	49	above	above	RB
cord-288868-qfdxri93	60	50	)	)	-RRB-
cord-288868-qfdxri93	60	51	,	,	,
cord-288868-qfdxri93	60	52	and	and	CC
cord-288868-qfdxri93	60	53	prototype	prototype	NN
cord-288868-qfdxri93	60	54	vaccines	vaccine	NNS
cord-288868-qfdxri93	60	55	for	for	IN
cord-288868-qfdxri93	60	56	these	these	DT
cord-288868-qfdxri93	60	57	strains	strain	NNS
cord-288868-qfdxri93	60	58	are	be	VBP
cord-288868-qfdxri93	60	59	being	be	VBG
cord-288868-qfdxri93	60	60	developed	develop	VBN
cord-288868-qfdxri93	60	61	.	.	.
cord-288868-qfdxri93	61	1	Apart	apart	RB
cord-288868-qfdxri93	61	2	from	from	IN
cord-288868-qfdxri93	61	3	almost	almost	RB
cord-288868-qfdxri93	61	4	complete	complete	JJ
cord-288868-qfdxri93	61	5	lack	lack	NN
cord-288868-qfdxri93	61	6	of	of	IN
cord-288868-qfdxri93	61	7	protection	protection	NN
cord-288868-qfdxri93	61	8	in	in	IN
cord-288868-qfdxri93	61	9	the	the	DT
cord-288868-qfdxri93	61	10	population	population	NN
cord-288868-qfdxri93	61	11	,	,	,
cord-288868-qfdxri93	61	12	an	an	DT
cord-288868-qfdxri93	61	13	additional	additional	JJ
cord-288868-qfdxri93	61	14	threat	threat	NN
cord-288868-qfdxri93	61	15	of	of	IN
cord-288868-qfdxri93	61	16	the	the	DT
cord-288868-qfdxri93	61	17	avian	avian	JJ
cord-288868-qfdxri93	61	18	flu	flu	NN
cord-288868-qfdxri93	61	19	H5N1	H5N1	NNP
cord-288868-qfdxri93	61	20	isolate	isolate	VBP
cord-288868-qfdxri93	61	21	from	from	IN
cord-288868-qfdxri93	61	22	2003	2003	CD
cord-288868-qfdxri93	61	23	is	be	VBZ
cord-288868-qfdxri93	61	24	that	that	IN
cord-288868-qfdxri93	61	25	it	-PRON-	PRP
cord-288868-qfdxri93	61	26	kills	kill	VBZ
cord-288868-qfdxri93	61	27	embryonated	embryonate	VBN
cord-288868-qfdxri93	61	28	eggs	egg	NNS
cord-288868-qfdxri93	61	29	,	,	,
cord-288868-qfdxri93	61	30	the	the	DT
cord-288868-qfdxri93	61	31	traditional	traditional	JJ
cord-288868-qfdxri93	61	32	virus	virus	NN
cord-288868-qfdxri93	61	33	growth	growth	NN
cord-288868-qfdxri93	61	34	substrate	substrate	NN
cord-288868-qfdxri93	61	35	used	use	VBN
cord-288868-qfdxri93	61	36	for	for	IN
cord-288868-qfdxri93	61	37	influenza	influenza	NN
cord-288868-qfdxri93	61	38	vaccine	vaccine	NN
cord-288868-qfdxri93	61	39	production	production	NN
cord-288868-qfdxri93	61	40	.	.	.
cord-288868-qfdxri93	62	1	Such	such	JJ
cord-288868-qfdxri93	62	2	problems	problem	NNS
cord-288868-qfdxri93	62	3	can	can	MD
cord-288868-qfdxri93	62	4	now	now	RB
cord-288868-qfdxri93	62	5	be	be	VB
cord-288868-qfdxri93	62	6	solved	solve	VBN
cord-288868-qfdxri93	62	7	,	,	,
cord-288868-qfdxri93	62	8	owing	owe	VBG
cord-288868-qfdxri93	62	9	to	to	IN
cord-288868-qfdxri93	62	10	the	the	DT
cord-288868-qfdxri93	62	11	discovery	discovery	NN
cord-288868-qfdxri93	62	12	some	some	DT
cord-288868-qfdxri93	62	13	years	year	NNS
cord-288868-qfdxri93	62	14	ago	ago	RB
cord-288868-qfdxri93	62	15	that	that	DT
cord-288868-qfdxri93	62	16	influenza	influenza	NN
cord-288868-qfdxri93	62	17	virus	virus	NN
cord-288868-qfdxri93	62	18	can	can	MD
cord-288868-qfdxri93	62	19	be	be	VB
cord-288868-qfdxri93	62	20	generated	generate	VBN
cord-288868-qfdxri93	62	21	entirely	entirely	RB
cord-288868-qfdxri93	62	22	from	from	IN
cord-288868-qfdxri93	62	23	transfected	transfecte	VBN
cord-288868-qfdxri93	62	24	DNA	dna	NN
cord-288868-qfdxri93	62	25	(	(	-LRB-
cord-288868-qfdxri93	62	26	reverse	reverse	JJ
cord-288868-qfdxri93	62	27	genetics	genetic	NNS
cord-288868-qfdxri93	62	28	[	[	-LRB-
cord-288868-qfdxri93	62	29	13	13	CD
cord-288868-qfdxri93	62	30	,	,	,
cord-288868-qfdxri93	62	31	14	14	CD
cord-288868-qfdxri93	62	32	]	]	-RRB-
cord-288868-qfdxri93	62	33	)	)	-RRB-
cord-288868-qfdxri93	62	34	.	.	.
cord-288868-qfdxri93	63	1	In	in	IN
cord-288868-qfdxri93	63	2	this	this	DT
cord-288868-qfdxri93	63	3	particular	particular	JJ
cord-288868-qfdxri93	63	4	case	case	NN
cord-288868-qfdxri93	63	5	,	,	,
cord-288868-qfdxri93	63	6	Webby	Webby	NNP
cord-288868-qfdxri93	63	7	et	et	NNP
cord-288868-qfdxri93	63	8	al	al	NNP
cord-288868-qfdxri93	63	9	.	.	.
cord-288868-qfdxri93	64	1	[	[	-LRB-
cord-288868-qfdxri93	64	2	15	15	CD
cord-288868-qfdxri93	64	3	]	]	-RRB-
cord-288868-qfdxri93	64	4	have	have	VBP
cord-288868-qfdxri93	64	5	used	use	VBN
cord-288868-qfdxri93	64	6	polymerase	polymerase	NN
cord-288868-qfdxri93	64	7	chain	chain	NN
cord-288868-qfdxri93	64	8	reaction	reaction	NN
cord-288868-qfdxri93	64	9	-	-	HYPH
cord-288868-qfdxri93	64	10	based	base	VBN
cord-288868-qfdxri93	64	11	mutagenesis	mutagenesis	NN
cord-288868-qfdxri93	64	12	to	to	TO
cord-288868-qfdxri93	64	13	replace	replace	VB
cord-288868-qfdxri93	64	14	the	the	DT
cord-288868-qfdxri93	64	15	hemagglutinin	hemagglutinin	NN
cord-288868-qfdxri93	64	16	cleavage	cleavage	NN
cord-288868-qfdxri93	64	17	site	site	NN
cord-288868-qfdxri93	64	18	(	(	-LRB-
cord-288868-qfdxri93	64	19	which	which	WDT
cord-288868-qfdxri93	64	20	was	be	VBD
cord-288868-qfdxri93	64	21	shown	show	VBN
cord-288868-qfdxri93	64	22	to	to	TO
cord-288868-qfdxri93	64	23	be	be	VB
cord-288868-qfdxri93	64	24	the	the	DT
cord-288868-qfdxri93	64	25	cause	cause	NN
cord-288868-qfdxri93	64	26	of	of	IN
cord-288868-qfdxri93	64	27	high	high	JJ
cord-288868-qfdxri93	64	28	pathogenicity	pathogenicity	NN
cord-288868-qfdxri93	64	29	)	)	-RRB-
cord-288868-qfdxri93	64	30	of	of	IN
cord-288868-qfdxri93	64	31	the	the	DT
cord-288868-qfdxri93	64	32	H5N1	H5N1	NNP
cord-288868-qfdxri93	64	33	strain	strain	NN
cord-288868-qfdxri93	64	34	with	with	IN
cord-288868-qfdxri93	64	35	the	the	DT
cord-288868-qfdxri93	64	36	sequence	sequence	NN
cord-288868-qfdxri93	64	37	from	from	IN
cord-288868-qfdxri93	64	38	a	a	DT
cord-288868-qfdxri93	64	39	nonpathogenic	nonpathogenic	JJ
cord-288868-qfdxri93	64	40	strain	strain	NN
cord-288868-qfdxri93	64	41	.	.	.
cord-288868-qfdxri93	65	1	Vero	Vero	NNP
cord-288868-qfdxri93	65	2	cells	cell	NNS
cord-288868-qfdxri93	65	3	were	be	VBD
cord-288868-qfdxri93	65	4	then	then	RB
cord-288868-qfdxri93	65	5	transfected	transfecte	VBN
cord-288868-qfdxri93	65	6	with	with	IN
cord-288868-qfdxri93	65	7	plasmids	plasmid	NNS
cord-288868-qfdxri93	65	8	encoding	encode	VBG
cord-288868-qfdxri93	65	9	the	the	DT
cord-288868-qfdxri93	65	10	neuraminidase	neuraminidase	NN
cord-288868-qfdxri93	65	11	and	and	CC
cord-288868-qfdxri93	65	12	mutated	mutate	VBN
cord-288868-qfdxri93	65	13	hemagglutinin	hemagglutinin	NN
cord-288868-qfdxri93	65	14	from	from	IN
cord-288868-qfdxri93	65	15	the	the	DT
cord-288868-qfdxri93	65	16	circulating	circulate	VBG
cord-288868-qfdxri93	65	17	strain	strain	NN
cord-288868-qfdxri93	65	18	,	,	,
cord-288868-qfdxri93	65	19	together	together	RB
cord-288868-qfdxri93	65	20	with	with	IN
cord-288868-qfdxri93	65	21	the	the	DT
cord-288868-qfdxri93	65	22	plasmids	plasmid	NNS
cord-288868-qfdxri93	65	23	encoding	encode	VBG
cord-288868-qfdxri93	65	24	the	the	DT
cord-288868-qfdxri93	65	25	remaining	remain	VBG
cord-288868-qfdxri93	65	26	proteins	protein	NNS
cord-288868-qfdxri93	65	27	from	from	IN
cord-288868-qfdxri93	65	28	the	the	DT
cord-288868-qfdxri93	65	29	laboratory	laboratory	NN
cord-288868-qfdxri93	65	30	-	-	HYPH
cord-288868-qfdxri93	65	31	optimized	optimize	VBN
cord-288868-qfdxri93	65	32	PR8	PR8	NNP
cord-288868-qfdxri93	65	33	strain	strain	NN
cord-288868-qfdxri93	65	34	.	.	.
cord-288868-qfdxri93	66	1	The	the	DT
cord-288868-qfdxri93	66	2	resulting	result	VBG
cord-288868-qfdxri93	66	3	vaccine	vaccine	NN
cord-288868-qfdxri93	66	4	strain	strain	NN
cord-288868-qfdxri93	66	5	was	be	VBD
cord-288868-qfdxri93	66	6	successfully	successfully	RB
cord-288868-qfdxri93	66	7	grown	grow	VBN
cord-288868-qfdxri93	66	8	in	in	IN
cord-288868-qfdxri93	66	9	eggs	egg	NNS
cord-288868-qfdxri93	66	10	and	and	CC
cord-288868-qfdxri93	66	11	shown	show	VBN
cord-288868-qfdxri93	66	12	to	to	TO
cord-288868-qfdxri93	66	13	be	be	VB
cord-288868-qfdxri93	66	14	nonpathogenic	nonpathogenic	JJ
cord-288868-qfdxri93	66	15	and	and	CC
cord-288868-qfdxri93	66	16	stable	stable	JJ
cord-288868-qfdxri93	66	17	.	.	.
cord-288868-qfdxri93	67	1	Thus	thus	RB
cord-288868-qfdxri93	67	2	,	,	,
cord-288868-qfdxri93	67	3	the	the	DT
cord-288868-qfdxri93	67	4	use	use	NN
cord-288868-qfdxri93	67	5	of	of	IN
cord-288868-qfdxri93	67	6	reverse	reverse	JJ
cord-288868-qfdxri93	67	7	genetics	genetics	NN
cord-288868-qfdxri93	67	8	enables	enable	VBZ
cord-288868-qfdxri93	67	9	rapid	rapid	JJ
cord-288868-qfdxri93	67	10	production	production	NN
cord-288868-qfdxri93	67	11	of	of	IN
cord-288868-qfdxri93	67	12	a	a	DT
cord-288868-qfdxri93	67	13	reference	reference	NN
cord-288868-qfdxri93	67	14	vaccine	vaccine	NN
cord-288868-qfdxri93	67	15	virus	virus	NN
cord-288868-qfdxri93	67	16	in	in	IN
cord-288868-qfdxri93	67	17	response	response	NN
cord-288868-qfdxri93	67	18	to	to	IN
cord-288868-qfdxri93	67	19	the	the	DT
cord-288868-qfdxri93	67	20	emergence	emergence	NN
cord-288868-qfdxri93	67	21	of	of	IN
cord-288868-qfdxri93	67	22	a	a	DT
cord-288868-qfdxri93	67	23	new	new	JJ
cord-288868-qfdxri93	67	24	influenza	influenza	NN
cord-288868-qfdxri93	67	25	variant	variant	NN
cord-288868-qfdxri93	67	26	[	[	-LRB-
cord-288868-qfdxri93	67	27	15	15	CD
cord-288868-qfdxri93	67	28	,	,	,
cord-288868-qfdxri93	67	29	16	16	CD
cord-288868-qfdxri93	67	30	]	]	-RRB-
cord-288868-qfdxri93	67	31	.	.	.
cord-288868-qfdxri93	68	1	In	in	IN
cord-288868-qfdxri93	68	2	addition	addition	NN
cord-288868-qfdxri93	68	3	,	,	,
cord-288868-qfdxri93	68	4	reverse	reverse	JJ
cord-288868-qfdxri93	68	5	genetics	genetic	NNS
cord-288868-qfdxri93	68	6	can	can	MD
cord-288868-qfdxri93	68	7	be	be	VB
cord-288868-qfdxri93	68	8	used	use	VBN
cord-288868-qfdxri93	68	9	for	for	IN
cord-288868-qfdxri93	68	10	more	more	RBR
cord-288868-qfdxri93	68	11	far	far	RB
cord-288868-qfdxri93	68	12	-	-	HYPH
cord-288868-qfdxri93	68	13	reaching	reach	VBG
cord-288868-qfdxri93	68	14	vaccination	vaccination	NN
cord-288868-qfdxri93	68	15	strategies	strategy	NNS
cord-288868-qfdxri93	68	16	,	,	,
cord-288868-qfdxri93	68	17	such	such	JJ
cord-288868-qfdxri93	68	18	as	as	IN
cord-288868-qfdxri93	68	19	the	the	DT
cord-288868-qfdxri93	68	20	construction	construction	NN
cord-288868-qfdxri93	68	21	of	of	IN
cord-288868-qfdxri93	68	22	'	'	``
cord-288868-qfdxri93	68	23	consensus	consensus	NN
cord-288868-qfdxri93	68	24	'	'	POS
cord-288868-qfdxri93	68	25	strains	strain	NNS
cord-288868-qfdxri93	68	26	expressing	express	VBG
cord-288868-qfdxri93	68	27	conserved	conserve	VBN
cord-288868-qfdxri93	68	28	amino	amino	NN
cord-288868-qfdxri93	68	29	acid	acid	NN
cord-288868-qfdxri93	68	30	sequences	sequence	NNS
cord-288868-qfdxri93	68	31	or	or	CC
cord-288868-qfdxri93	68	32	more	more	JJR
cord-288868-qfdxri93	68	33	than	than	IN
cord-288868-qfdxri93	68	34	one	one	CD
cord-288868-qfdxri93	68	35	version	version	NN
cord-288868-qfdxri93	68	36	of	of	IN
cord-288868-qfdxri93	68	37	the	the	DT
cord-288868-qfdxri93	68	38	surface	surface	NN
cord-288868-qfdxri93	68	39	glycoproteins	glycoprotein	NNS
cord-288868-qfdxri93	68	40	,	,	,
cord-288868-qfdxri93	68	41	or	or	CC
cord-288868-qfdxri93	68	42	additional	additional	JJ
cord-288868-qfdxri93	68	43	immunoenhancing	immunoenhancing	NN
cord-288868-qfdxri93	68	44	molecules	molecule	NNS
cord-288868-qfdxri93	68	45	,	,	,
cord-288868-qfdxri93	68	46	such	such	JJ
cord-288868-qfdxri93	68	47	as	as	IN
cord-288868-qfdxri93	68	48	cytokines	cytokine	NNS
cord-288868-qfdxri93	68	49	[	[	-LRB-
cord-288868-qfdxri93	68	50	8	8	CD
cord-288868-qfdxri93	68	51	]	]	-RRB-
cord-288868-qfdxri93	68	52	.	.	.
cord-288868-qfdxri93	69	1	Much	much	JJ
cord-288868-qfdxri93	69	2	research	research	NN
cord-288868-qfdxri93	69	3	effort	effort	NN
cord-288868-qfdxri93	69	4	is	be	VBZ
cord-288868-qfdxri93	69	5	also	also	RB
cord-288868-qfdxri93	69	6	being	be	VBG
cord-288868-qfdxri93	69	7	invested	invest	VBN
cord-288868-qfdxri93	69	8	into	into	IN
cord-288868-qfdxri93	69	9	the	the	DT
cord-288868-qfdxri93	69	10	development	development	NN
cord-288868-qfdxri93	69	11	of	of	IN
cord-288868-qfdxri93	69	12	improved	improved	JJ
cord-288868-qfdxri93	69	13	cell	cell	NN
cord-288868-qfdxri93	69	14	culture	culture	NN
cord-288868-qfdxri93	69	15	systems	system	NNS
cord-288868-qfdxri93	69	16	that	that	WDT
cord-288868-qfdxri93	69	17	can	can	MD
cord-288868-qfdxri93	69	18	replace	replace	VB
cord-288868-qfdxri93	69	19	completely	completely	RB
cord-288868-qfdxri93	69	20	the	the	DT
cord-288868-qfdxri93	69	21	use	use	NN
cord-288868-qfdxri93	69	22	of	of	IN
cord-288868-qfdxri93	69	23	embryonated	embryonate	VBN
cord-288868-qfdxri93	69	24	eggs	egg	NNS
cord-288868-qfdxri93	69	25	in	in	IN
cord-288868-qfdxri93	69	26	vaccine	vaccine	NN
cord-288868-qfdxri93	69	27	production	production	NN
cord-288868-qfdxri93	69	28	and	and	CC
cord-288868-qfdxri93	69	29	would	would	MD
cord-288868-qfdxri93	69	30	render	render	VB
cord-288868-qfdxri93	69	31	the	the	DT
cord-288868-qfdxri93	69	32	production	production	NN
cord-288868-qfdxri93	69	33	process	process	NN
cord-288868-qfdxri93	69	34	more	more	RBR
cord-288868-qfdxri93	69	35	flexible	flexible	JJ
cord-288868-qfdxri93	69	36	and	and	CC
cord-288868-qfdxri93	69	37	controllable	controllable	JJ
cord-288868-qfdxri93	69	38	.	.	.
cord-288868-qfdxri93	70	1	Several	several	JJ
cord-288868-qfdxri93	70	2	reports	report	NNS
cord-288868-qfdxri93	70	3	have	have	VBP
cord-288868-qfdxri93	70	4	addressed	address	VBN
cord-288868-qfdxri93	70	5	the	the	DT
cord-288868-qfdxri93	70	6	question	question	NN
cord-288868-qfdxri93	70	7	of	of	IN
cord-288868-qfdxri93	70	8	how	how	WRB
cord-288868-qfdxri93	70	9	to	to	TO
cord-288868-qfdxri93	70	10	stretch	stretch	VB
cord-288868-qfdxri93	70	11	the	the	DT
cord-288868-qfdxri93	70	12	available	available	JJ
cord-288868-qfdxri93	70	13	supply	supply	NN
cord-288868-qfdxri93	70	14	of	of	IN
cord-288868-qfdxri93	70	15	vaccine	vaccine	NN
cord-288868-qfdxri93	70	16	doses	dose	NNS
cord-288868-qfdxri93	70	17	in	in	IN
cord-288868-qfdxri93	70	18	cases	case	NNS
cord-288868-qfdxri93	70	19	of	of	IN
cord-288868-qfdxri93	70	20	shortage	shortage	NN
cord-288868-qfdxri93	70	21	or	or	CC
cord-288868-qfdxri93	70	22	in	in	IN
cord-288868-qfdxri93	70	23	the	the	DT
cord-288868-qfdxri93	70	24	face	face	NN
cord-288868-qfdxri93	70	25	of	of	IN
cord-288868-qfdxri93	70	26	a	a	DT
cord-288868-qfdxri93	70	27	pandemic	pandemic	NN
cord-288868-qfdxri93	70	28	.	.	.
cord-288868-qfdxri93	71	1	Two	two	CD
cord-288868-qfdxri93	71	2	studies	study	NNS
cord-288868-qfdxri93	71	3	indicated	indicate	VBD
cord-288868-qfdxri93	71	4	that	that	IN
cord-288868-qfdxri93	71	5	intradermal	intradermal	JJ
cord-288868-qfdxri93	71	6	,	,	,
cord-288868-qfdxri93	71	7	rather	rather	RB
cord-288868-qfdxri93	71	8	than	than	IN
cord-288868-qfdxri93	71	9	intramuscular	intramuscular	JJ
cord-288868-qfdxri93	71	10	,	,	,
cord-288868-qfdxri93	71	11	application	application	NN
cord-288868-qfdxri93	71	12	of	of	IN
cord-288868-qfdxri93	71	13	40	40	CD
cord-288868-qfdxri93	71	14	%	%	NN
cord-288868-qfdxri93	71	15	[	[	-LRB-
cord-288868-qfdxri93	71	16	17	17	CD
cord-288868-qfdxri93	71	17	]	]	-RRB-
cord-288868-qfdxri93	71	18	 	 	_SP
cord-288868-qfdxri93	72	1	The	the	DT
cord-288868-qfdxri93	72	2	genomic	genomic	JJ
cord-288868-qfdxri93	72	3	revolution	revolution	NN
cord-288868-qfdxri93	72	4	has	have	VBZ
cord-288868-qfdxri93	72	5	opened	open	VBN
cord-288868-qfdxri93	72	6	up	up	RP
cord-288868-qfdxri93	72	7	a	a	DT
cord-288868-qfdxri93	72	8	completely	completely	RB
cord-288868-qfdxri93	72	9	new	new	JJ
cord-288868-qfdxri93	72	10	approach	approach	NN
cord-288868-qfdxri93	72	11	to	to	IN
cord-288868-qfdxri93	72	12	vaccine	vaccine	NN
cord-288868-qfdxri93	72	13	discovery	discovery	NN
cord-288868-qfdxri93	72	14	.	.	.
cord-288868-qfdxri93	73	1	For	for	IN
cord-288868-qfdxri93	73	2	pathogens	pathogen	NNS
cord-288868-qfdxri93	73	3	that	that	WDT
cord-288868-qfdxri93	73	4	do	do	VBP
cord-288868-qfdxri93	73	5	not	not	RB
cord-288868-qfdxri93	73	6	grow	grow	VB
cord-288868-qfdxri93	73	7	in	in	IN
cord-288868-qfdxri93	73	8	vitro	vitro	FW
cord-288868-qfdxri93	73	9	,	,	,
cord-288868-qfdxri93	73	10	the	the	DT
cord-288868-qfdxri93	73	11	availability	availability	NN
cord-288868-qfdxri93	73	12	of	of	IN
cord-288868-qfdxri93	73	13	the	the	DT
cord-288868-qfdxri93	73	14	genome	genome	NN
cord-288868-qfdxri93	73	15	sequence	sequence	NN
cord-288868-qfdxri93	73	16	has	have	VBZ
cord-288868-qfdxri93	73	17	enabled	enable	VBN
cord-288868-qfdxri93	73	18	the	the	DT
cord-288868-qfdxri93	73	19	development	development	NN
cord-288868-qfdxri93	73	20	of	of	IN
cord-288868-qfdxri93	73	21	recombinant	recombinant	JJ
cord-288868-qfdxri93	73	22	vaccines	vaccine	NNS
cord-288868-qfdxri93	73	23	,	,	,
cord-288868-qfdxri93	73	24	as	as	IN
cord-288868-qfdxri93	73	25	has	have	VBZ
cord-288868-qfdxri93	73	26	been	be	VBN
cord-288868-qfdxri93	73	27	carried	carry	VBN
cord-288868-qfdxri93	73	28	out	out	RP
cord-288868-qfdxri93	73	29	for	for	IN
cord-288868-qfdxri93	73	30	hepatitis	hepatitis	NN
cord-288868-qfdxri93	73	31	B	B	NNP
cord-288868-qfdxri93	73	32	virus	virus	NN
cord-288868-qfdxri93	73	33	(	(	-LRB-
cord-288868-qfdxri93	73	34	HBV	HBV	NNP
cord-288868-qfdxri93	73	35	)	)	-RRB-
cord-288868-qfdxri93	73	36	and	and	CC
cord-288868-qfdxri93	73	37	is	be	VBZ
cord-288868-qfdxri93	73	38	underway	underway	JJ
cord-288868-qfdxri93	73	39	for	for	IN
cord-288868-qfdxri93	73	40	hepatitis	hepatitis	NNP
cord-288868-qfdxri93	73	41	C.	C.	NNP
cord-288868-qfdxri93	74	1	In	in	IN
cord-288868-qfdxri93	74	2	regard	regard	NN
cord-288868-qfdxri93	74	3	to	to	IN
cord-288868-qfdxri93	74	4	bacteria	bacteria	NNS
cord-288868-qfdxri93	74	5	,	,	,
cord-288868-qfdxri93	74	6	group	group	NN
cord-288868-qfdxri93	74	7	B	B	NNP
cord-288868-qfdxri93	74	8	meningococcus	meningococcus	NNP
cord-288868-qfdxri93	74	9	posed	pose	VBD
cord-288868-qfdxri93	74	10	insurmountable	insurmountable	JJ
cord-288868-qfdxri93	74	11	obstacles	obstacle	NNS
cord-288868-qfdxri93	74	12	to	to	IN
cord-288868-qfdxri93	74	13	conventional	conventional	JJ
cord-288868-qfdxri93	74	14	vaccinology	vaccinology	NN
cord-288868-qfdxri93	74	15	approaches	approach	NNS
cord-288868-qfdxri93	74	16	;	;	:
cord-288868-qfdxri93	74	17	these	these	DT
cord-288868-qfdxri93	74	18	were	be	VBD
cord-288868-qfdxri93	74	19	eventually	eventually	RB
cord-288868-qfdxri93	74	20	overcome	overcome	VBN
cord-288868-qfdxri93	74	21	by	by	IN
cord-288868-qfdxri93	74	22	mining	mine	VBG
cord-288868-qfdxri93	74	23	the	the	DT
cord-288868-qfdxri93	74	24	information	information	NN
cord-288868-qfdxri93	74	25	from	from	IN
cord-288868-qfdxri93	74	26	the	the	DT
cord-288868-qfdxri93	74	27	sequenced	sequence	VBN
cord-288868-qfdxri93	74	28	genome	genome	NN
cord-288868-qfdxri93	74	29	[	[	-LRB-
cord-288868-qfdxri93	74	30	23	23	CD
cord-288868-qfdxri93	74	31	]	]	-RRB-
cord-288868-qfdxri93	74	32	.	.	.
cord-288868-qfdxri93	75	1	A	a	DT
cord-288868-qfdxri93	75	2	total	total	NN
cord-288868-qfdxri93	75	3	of	of	IN
cord-288868-qfdxri93	75	4	600	600	CD
cord-288868-qfdxri93	75	5	potential	potential	JJ
cord-288868-qfdxri93	75	6	vaccine	vaccine	NN
cord-288868-qfdxri93	75	7	candidates	candidate	NNS
cord-288868-qfdxri93	75	8	were	be	VBD
cord-288868-qfdxri93	75	9	predicted	predict	VBN
cord-288868-qfdxri93	75	10	by	by	IN
cord-288868-qfdxri93	75	11	computer	computer	NN
cord-288868-qfdxri93	75	12	analysis	analysis	NN
cord-288868-qfdxri93	75	13	,	,	,
cord-288868-qfdxri93	75	14	350	350	CD
cord-288868-qfdxri93	75	15	of	of	IN
cord-288868-qfdxri93	75	16	which	which	WDT
cord-288868-qfdxri93	75	17	were	be	VBD
cord-288868-qfdxri93	75	18	expressed	express	VBN
cord-288868-qfdxri93	75	19	and	and	CC
cord-288868-qfdxri93	75	20	tested	test	VBN
cord-288868-qfdxri93	75	21	for	for	IN
cord-288868-qfdxri93	75	22	immunogenicity	immunogenicity	NN
cord-288868-qfdxri93	75	23	[	[	-LRB-
cord-288868-qfdxri93	75	24	24	24	CD
cord-288868-qfdxri93	75	25	]	]	-RRB-
cord-288868-qfdxri93	75	26	.	.	.
cord-288868-qfdxri93	76	1	Some	some	DT
cord-288868-qfdxri93	76	2	of	of	IN
cord-288868-qfdxri93	76	3	these	these	DT
cord-288868-qfdxri93	76	4	candidates	candidate	NNS
cord-288868-qfdxri93	76	5	are	be	VBP
cord-288868-qfdxri93	76	6	now	now	RB
cord-288868-qfdxri93	76	7	in	in	IN
cord-288868-qfdxri93	76	8	clinical	clinical	JJ
cord-288868-qfdxri93	76	9	trials	trial	NNS
cord-288868-qfdxri93	76	10	.	.	.
cord-288868-qfdxri93	77	1	This	this	DT
cord-288868-qfdxri93	77	2	genomebased	genomebase	VBN
cord-288868-qfdxri93	77	3	approach	approach	NN
cord-288868-qfdxri93	77	4	,	,	,
cord-288868-qfdxri93	77	5	called	call	VBN
cord-288868-qfdxri93	77	6	reverse	reverse	JJ
cord-288868-qfdxri93	77	7	vaccinology	vaccinology	NN
cord-288868-qfdxri93	77	8	,	,	,
cord-288868-qfdxri93	77	9	is	be	VBZ
cord-288868-qfdxri93	77	10	now	now	RB
cord-288868-qfdxri93	77	11	used	use	VBN
cord-288868-qfdxri93	77	12	routinely	routinely	RB
cord-288868-qfdxri93	77	13	in	in	IN
cord-288868-qfdxri93	77	14	vaccine	vaccine	NN
cord-288868-qfdxri93	77	15	development	development	NN
cord-288868-qfdxri93	77	16	,	,	,
cord-288868-qfdxri93	77	17	and	and	CC
cord-288868-qfdxri93	77	18	is	be	VBZ
cord-288868-qfdxri93	77	19	a	a	DT
cord-288868-qfdxri93	77	20	major	major	JJ
cord-288868-qfdxri93	77	21	tool	tool	NN
cord-288868-qfdxri93	77	22	in	in	IN
cord-288868-qfdxri93	77	23	the	the	DT
cord-288868-qfdxri93	77	24	quest	quest	NN
cord-288868-qfdxri93	77	25	for	for	IN
cord-288868-qfdxri93	77	26	vaccines	vaccine	NNS
cord-288868-qfdxri93	77	27	against	against	IN
cord-288868-qfdxri93	77	28	pneumococcus	pneumococcus	NNP
cord-288868-qfdxri93	77	29	,	,	,
cord-288868-qfdxri93	77	30	group	group	NN
cord-288868-qfdxri93	77	31	B	B	NNP
cord-288868-qfdxri93	77	32	streptococcus	streptococcus	NN
cord-288868-qfdxri93	77	33	and	and	CC
cord-288868-qfdxri93	77	34	chlamydia	chlamydia	NNS
cord-288868-qfdxri93	77	35	(	(	-LRB-
cord-288868-qfdxri93	77	36	see	see	VB
cord-288868-qfdxri93	77	37	also	also	RB
cord-288868-qfdxri93	77	38	Update	update	VB
cord-288868-qfdxri93	77	39	)	)	-RRB-
cord-288868-qfdxri93	77	40	.	.	.
cord-288868-qfdxri93	78	1	Recently	recently	RB
cord-288868-qfdxri93	78	2	,	,	,
cord-288868-qfdxri93	78	3	genome	genome	NN
cord-288868-qfdxri93	78	4	sequencing	sequencing	NN
cord-288868-qfdxri93	78	5	of	of	IN
cord-288868-qfdxri93	78	6	both	both	DT
cord-288868-qfdxri93	78	7	Plasmodium	Plasmodium	NNP
cord-288868-qfdxri93	78	8	falciparum	falciparum	NNS
cord-288868-qfdxri93	78	9	[	[	-LRB-
cord-288868-qfdxri93	78	10	25	25	CD
cord-288868-qfdxri93	78	11	]	]	-RRB-
cord-288868-qfdxri93	78	12	and	and	CC
cord-288868-qfdxri93	78	13	its	-PRON-	PRP$
cord-288868-qfdxri93	78	14	main	main	JJ
cord-288868-qfdxri93	78	15	vector	vector	NN
cord-288868-qfdxri93	78	16	,	,	,
cord-288868-qfdxri93	78	17	Anopheles	Anopheles	NNP
cord-288868-qfdxri93	78	18	gambiae	gambiae	NN
cord-288868-qfdxri93	78	19	[	[	-LRB-
cord-288868-qfdxri93	78	20	26	26	CD
cord-288868-qfdxri93	78	21	]	]	-RRB-
cord-288868-qfdxri93	78	22	,	,	,
cord-288868-qfdxri93	78	23	has	have	VBZ
cord-288868-qfdxri93	78	24	sparked	spark	VBN
cord-288868-qfdxri93	78	25	off	off	RP
cord-288868-qfdxri93	78	26	new	new	JJ
cord-288868-qfdxri93	78	27	hopes	hope	NNS
cord-288868-qfdxri93	78	28	for	for	IN
cord-288868-qfdxri93	78	29	an	an	DT
cord-288868-qfdxri93	78	30	efficient	efficient	JJ
cord-288868-qfdxri93	78	31	vaccine	vaccine	NN
cord-288868-qfdxri93	78	32	against	against	IN
cord-288868-qfdxri93	78	33	malaria	malaria	NN
cord-288868-qfdxri93	78	34	.	.	.
cord-288868-qfdxri93	79	1	For	for	IN
cord-288868-qfdxri93	79	2	the	the	DT
cord-288868-qfdxri93	79	3	rodent	rodent	NN
cord-288868-qfdxri93	79	4	models	model	NNS
cord-288868-qfdxri93	79	5	of	of	IN
cord-288868-qfdxri93	79	6	this	this	DT
cord-288868-qfdxri93	79	7	disease	disease	NN
cord-288868-qfdxri93	79	8	,	,	,
cord-288868-qfdxri93	79	9	subtractive	subtractive	JJ
cord-288868-qfdxri93	79	10	cDNA	cdna	NN
cord-288868-qfdxri93	79	11	techniques	technique	NNS
cord-288868-qfdxri93	79	12	were	be	VBD
cord-288868-qfdxri93	79	13	used	use	VBN
cord-288868-qfdxri93	79	14	to	to	TO
cord-288868-qfdxri93	79	15	identify	identify	VB
cord-288868-qfdxri93	79	16	genes	gene	NNS
cord-288868-qfdxri93	79	17	that	that	WDT
cord-288868-qfdxri93	79	18	are	be	VBP
cord-288868-qfdxri93	79	19	only	only	RB
cord-288868-qfdxri93	79	20	expressed	express	VBN
cord-288868-qfdxri93	79	21	in	in	IN
cord-288868-qfdxri93	79	22	pre	pre	JJ
cord-288868-qfdxri93	79	23	-	-	JJ
cord-288868-qfdxri93	79	24	erythrocytic	erythrocytic	JJ
cord-288868-qfdxri93	79	25	stages	stage	NNS
cord-288868-qfdxri93	79	26	of	of	IN
cord-288868-qfdxri93	79	27	the	the	DT
cord-288868-qfdxri93	79	28	parasite	parasite	NN
cord-288868-qfdxri93	79	29	[	[	-LRB-
cord-288868-qfdxri93	79	30	27,28	27,28	CD
cord-288868-qfdxri93	79	31	]	]	-RRB-
cord-288868-qfdxri93	79	32	.	.	.
cord-288868-qfdxri93	80	1	Plasmodium	plasmodium	NN
cord-288868-qfdxri93	80	2	mutants	mutant	NNS
cord-288868-qfdxri93	80	3	deficient	deficient	JJ
cord-288868-qfdxri93	80	4	in	in	IN
cord-288868-qfdxri93	80	5	one	one	CD
cord-288868-qfdxri93	80	6	of	of	IN
cord-288868-qfdxri93	80	7	these	these	DT
cord-288868-qfdxri93	80	8	genes	gene	NNS
cord-288868-qfdxri93	80	9	,	,	,
cord-288868-qfdxri93	80	10	uis3	uis3	NNP
cord-288868-qfdxri93	80	11	,	,	,
cord-288868-qfdxri93	80	12	are	be	VBP
cord-288868-qfdxri93	80	13	blocked	block	VBN
cord-288868-qfdxri93	80	14	in	in	IN
cord-288868-qfdxri93	80	15	their	-PRON-	PRP$
cord-288868-qfdxri93	80	16	early	early	JJ
cord-288868-qfdxri93	80	17	liver	liver	NN
cord-288868-qfdxri93	80	18	-	-	HYPH
cord-288868-qfdxri93	80	19	stage	stage	NN
cord-288868-qfdxri93	80	20	development	development	NN
cord-288868-qfdxri93	80	21	and	and	CC
cord-288868-qfdxri93	80	22	all	all	DT
cord-288868-qfdxri93	80	23	subsequent	subsequent	JJ
cord-288868-qfdxri93	80	24	stages	stage	NNS
cord-288868-qfdxri93	80	25	,	,	,
cord-288868-qfdxri93	80	26	and	and	CC
cord-288868-qfdxri93	80	27	therefore	therefore	RB
cord-288868-qfdxri93	80	28	do	do	VBP
cord-288868-qfdxri93	80	29	not	not	RB
cord-288868-qfdxri93	80	30	lead	lead	VB
cord-288868-qfdxri93	80	31	to	to	IN
cord-288868-qfdxri93	80	32	disease	disease	NN
cord-288868-qfdxri93	80	33	.	.	.
cord-288868-qfdxri93	81	1	When	when	WRB
cord-288868-qfdxri93	81	2	uis3-deficient	uis3-deficient	NNP
cord-288868-qfdxri93	81	3	sporozoites	sporozoite	NNS
cord-288868-qfdxri93	81	4	are	be	VBP
cord-288868-qfdxri93	81	5	used	use	VBN
cord-288868-qfdxri93	81	6	as	as	IN
cord-288868-qfdxri93	81	7	genetically	genetically	RB
cord-288868-qfdxri93	81	8	attenuated	attenuate	VBN
cord-288868-qfdxri93	81	9	vaccines	vaccine	NNS
cord-288868-qfdxri93	81	10	in	in	IN
cord-288868-qfdxri93	81	11	mice	mouse	NNS
cord-288868-qfdxri93	81	12	,	,	,
cord-288868-qfdxri93	81	13	they	-PRON-	PRP
cord-288868-qfdxri93	81	14	confer	confer	VBP
cord-288868-qfdxri93	81	15	long	long	RB
cord-288868-qfdxri93	81	16	-	-	HYPH
cord-288868-qfdxri93	81	17	lasting	last	VBG
cord-288868-qfdxri93	81	18	,	,	,
cord-288868-qfdxri93	81	19	stage	stage	NN
cord-288868-qfdxri93	81	20	-	-	HYPH
cord-288868-qfdxri93	81	21	specific	specific	JJ
cord-288868-qfdxri93	81	22	protection	protection	NN
cord-288868-qfdxri93	81	23	[	[	-LRB-
cord-288868-qfdxri93	81	24	29	29	CD
cord-288868-qfdxri93	81	25	]	]	-RRB-
cord-288868-qfdxri93	81	26	.	.	.
cord-288868-qfdxri93	82	1	This	this	DT
cord-288868-qfdxri93	82	2	is	be	VBZ
cord-288868-qfdxri93	82	3	a	a	DT
cord-288868-qfdxri93	82	4	promising	promising	JJ
cord-288868-qfdxri93	82	5	example	example	NN
cord-288868-qfdxri93	82	6	of	of	IN
cord-288868-qfdxri93	82	7	how	how	WRB
cord-288868-qfdxri93	82	8	molecular	molecular	JJ
cord-288868-qfdxri93	82	9	approaches	approach	NNS
cord-288868-qfdxri93	82	10	are	be	VBP
cord-288868-qfdxri93	82	11	employed	employ	VBN
cord-288868-qfdxri93	82	12	for	for	IN
cord-288868-qfdxri93	82	13	the	the	DT
cord-288868-qfdxri93	82	14	rational	rational	JJ
cord-288868-qfdxri93	82	15	design	design	NN
cord-288868-qfdxri93	82	16	of	of	IN
cord-288868-qfdxri93	82	17	new	new	JJ
cord-288868-qfdxri93	82	18	vaccines	vaccine	NNS
cord-288868-qfdxri93	82	19	.	.	.
cord-288868-qfdxri93	83	1	Another	another	DT
cord-288868-qfdxri93	83	2	example	example	NN
cord-288868-qfdxri93	83	3	of	of	IN
cord-288868-qfdxri93	83	4	encouraging	encouraging	JJ
cord-288868-qfdxri93	83	5	progress	progress	NN
cord-288868-qfdxri93	83	6	towards	towards	IN
cord-288868-qfdxri93	83	7	a	a	DT
cord-288868-qfdxri93	83	8	malaria	malaria	NN
cord-288868-qfdxri93	83	9	vaccine	vaccine	NN
cord-288868-qfdxri93	83	10	was	be	VBD
cord-288868-qfdxri93	83	11	reported	report	VBN
cord-288868-qfdxri93	83	12	by	by	IN
cord-288868-qfdxri93	83	13	Alonso	Alonso	NNP
cord-288868-qfdxri93	83	14	et	et	NNP
cord-288868-qfdxri93	83	15	al	al	NNP
cord-288868-qfdxri93	83	16	.	.	.
cord-288868-qfdxri93	84	1	[	[	-LRB-
cord-288868-qfdxri93	84	2	30	30	CD
cord-288868-qfdxri93	84	3	]	]	-RRB-
cord-288868-qfdxri93	84	4	.	.	.
cord-288868-qfdxri93	85	1	They	-PRON-	PRP
cord-288868-qfdxri93	85	2	describe	describe	VBP
cord-288868-qfdxri93	85	3	Phase	phase	NN
cord-288868-qfdxri93	85	4	IIb	iib	JJ
cord-288868-qfdxri93	85	5	trials	trial	NNS
cord-288868-qfdxri93	85	6	of	of	IN
cord-288868-qfdxri93	85	7	a	a	DT
cord-288868-qfdxri93	85	8	subunit	subunit	NN
cord-288868-qfdxri93	85	9	vaccine	vaccine	NN
cord-288868-qfdxri93	85	10	consisting	consist	VBG
cord-288868-qfdxri93	85	11	of	of	IN
cord-288868-qfdxri93	85	12	a	a	DT
cord-288868-qfdxri93	85	13	recombinant	recombinant	JJ
cord-288868-qfdxri93	85	14	protein	protein	NN
cord-288868-qfdxri93	85	15	(	(	-LRB-
cord-288868-qfdxri93	85	16	expressed	express	VBN
cord-288868-qfdxri93	85	17	in	in	IN
cord-288868-qfdxri93	85	18	yeast	yeast	NN
cord-288868-qfdxri93	85	19	)	)	-RRB-
cord-288868-qfdxri93	85	20	composed	compose	VBN
cord-288868-qfdxri93	85	21	of	of	IN
cord-288868-qfdxri93	85	22	the	the	DT
cord-288868-qfdxri93	85	23	carboxy	carboxy	JJ
cord-288868-qfdxri93	85	24	-	-	HYPH
cord-288868-qfdxri93	85	25	terminal	terminal	NN
cord-288868-qfdxri93	85	26	of	of	IN
cord-288868-qfdxri93	85	27	the	the	DT
cord-288868-qfdxri93	85	28	P.	P.	NNP
cord-288868-qfdxri93	85	29	falciparum	falciparum	NN
cord-288868-qfdxri93	85	30	circumsporozoite	circumsporozoite	JJ
cord-288868-qfdxri93	85	31	protein	protein	NN
cord-288868-qfdxri93	85	32	and	and	CC
cord-288868-qfdxri93	85	33	the	the	DT
cord-288868-qfdxri93	85	34	HBV	HBV	NNP
cord-288868-qfdxri93	85	35	surface	surface	NN
cord-288868-qfdxri93	85	36	antigen	antigen	NN
cord-288868-qfdxri93	85	37	.	.	.
cord-288868-qfdxri93	86	1	This	this	DT
cord-288868-qfdxri93	86	2	fusion	fusion	NN
cord-288868-qfdxri93	86	3	protein	protein	NN
cord-288868-qfdxri93	86	4	,	,	,
cord-288868-qfdxri93	86	5	together	together	RB
cord-288868-qfdxri93	86	6	with	with	IN
cord-288868-qfdxri93	86	7	unfused	unfused	JJ
cord-288868-qfdxri93	86	8	HBV	HBV	NNP
cord-288868-qfdxri93	86	9	surface	surface	NN
cord-288868-qfdxri93	86	10	antigen	antigen	NN
cord-288868-qfdxri93	86	11	proteins	protein	NNS
cord-288868-qfdxri93	86	12	,	,	,
cord-288868-qfdxri93	86	13	forms	form	NNS
cord-288868-qfdxri93	86	14	particles	particle	NNS
cord-288868-qfdxri93	86	15	.	.	.
cord-288868-qfdxri93	87	1	The	the	DT
cord-288868-qfdxri93	87	2	final	final	JJ
cord-288868-qfdxri93	87	3	vaccine	vaccine	NN
cord-288868-qfdxri93	87	4	formulation	formulation	NN
cord-288868-qfdxri93	87	5	includes	include	VBZ
cord-288868-qfdxri93	87	6	the	the	DT
cord-288868-qfdxri93	87	7	adjuvant	adjuvant	JJ
cord-288868-qfdxri93	87	8	AS02A	as02a	NN
cord-288868-qfdxri93	87	9	,	,	,
cord-288868-qfdxri93	87	10	an	an	DT
cord-288868-qfdxri93	87	11	oil	oil	NN
cord-288868-qfdxri93	87	12	in	in	IN
cord-288868-qfdxri93	87	13	water	water	NN
cord-288868-qfdxri93	87	14	emulsion	emulsion	NN
cord-288868-qfdxri93	87	15	containing	contain	VBG
cord-288868-qfdxri93	87	16	the	the	DT
cord-288868-qfdxri93	87	17	immunostimulants	immunostimulant	NNS
cord-288868-qfdxri93	87	18	monophosphoryl	monophosphoryl	NNP
cord-288868-qfdxri93	87	19	lipid	lipid	VBG
cord-288868-qfdxri93	87	20	A	A	NNP
cord-288868-qfdxri93	87	21	(	(	-LRB-
cord-288868-qfdxri93	87	22	MPL	MPL	NNP
cord-288868-qfdxri93	87	23	)	)	-RRB-
cord-288868-qfdxri93	87	24	and	and	CC
cord-288868-qfdxri93	87	25	Quillaja	Quillaja	NNP
cord-288868-qfdxri93	87	26	saponaria	saponaria	NNP
cord-288868-qfdxri93	87	27	fraction	fraction	NNP
cord-288868-qfdxri93	87	28	21	21	CD
cord-288868-qfdxri93	87	29	.	.	.
cord-288868-qfdxri93	88	1	It	-PRON-	PRP
cord-288868-qfdxri93	88	2	had	have	VBD
cord-288868-qfdxri93	88	3	previously	previously	RB
cord-288868-qfdxri93	88	4	been	be	VBN
cord-288868-qfdxri93	88	5	shown	show	VBN
cord-288868-qfdxri93	88	6	that	that	IN
cord-288868-qfdxri93	88	7	,	,	,
cord-288868-qfdxri93	88	8	indeed	indeed	RB
cord-288868-qfdxri93	88	9	,	,	,
cord-288868-qfdxri93	88	10	a	a	DT
cord-288868-qfdxri93	88	11	CD4	CD4	NNP
cord-288868-qfdxri93	88	12	+	+	CC
cord-288868-qfdxri93	88	13	T	T	NNP
cord-288868-qfdxri93	88	14	cell	cell	NN
cord-288868-qfdxri93	88	15	response	response	NN
cord-288868-qfdxri93	88	16	to	to	IN
cord-288868-qfdxri93	88	17	an	an	DT
cord-288868-qfdxri93	88	18	epitope	epitope	NN
cord-288868-qfdxri93	88	19	contained	contain	VBN
cord-288868-qfdxri93	88	20	in	in	IN
cord-288868-qfdxri93	88	21	the	the	DT
cord-288868-qfdxri93	88	22	vaccine	vaccine	NN
cord-288868-qfdxri93	88	23	correlates	correlate	VBZ
cord-288868-qfdxri93	88	24	with	with	IN
cord-288868-qfdxri93	88	25	protection	protection	NN
cord-288868-qfdxri93	88	26	from	from	IN
cord-288868-qfdxri93	88	27	infection	infection	NN
cord-288868-qfdxri93	88	28	and	and	CC
cord-288868-qfdxri93	88	29	disease	disease	NN
cord-288868-qfdxri93	88	30	[	[	-LRB-
cord-288868-qfdxri93	88	31	31	31	CD
cord-288868-qfdxri93	88	32	]	]	-RRB-
cord-288868-qfdxri93	88	33	.	.	.
cord-288868-qfdxri93	89	1	In	in	IN
cord-288868-qfdxri93	89	2	this	this	DT
cord-288868-qfdxri93	89	3	trial	trial	NN
cord-288868-qfdxri93	89	4	in	in	IN
cord-288868-qfdxri93	89	5	children	child	NNS
cord-288868-qfdxri93	89	6	,	,	,
cord-288868-qfdxri93	89	7	the	the	DT
cord-288868-qfdxri93	89	8	vaccine	vaccine	NN
cord-288868-qfdxri93	89	9	showed	show	VBD
cord-288868-qfdxri93	89	10	an	an	DT
cord-288868-qfdxri93	89	11	efficacy	efficacy	NN
cord-288868-qfdxri93	89	12	of	of	IN
cord-288868-qfdxri93	89	13	30	30	CD
cord-288868-qfdxri93	89	14	%	%	NN
cord-288868-qfdxri93	89	15	and	and	CC
cord-288868-qfdxri93	89	16	58	58	CD
cord-288868-qfdxri93	89	17	%	%	NN
cord-288868-qfdxri93	89	18	in	in	IN
cord-288868-qfdxri93	89	19	preventing	prevent	VBG
cord-288868-qfdxri93	89	20	clinical	clinical	JJ
cord-288868-qfdxri93	89	21	episodes	episode	NNS
cord-288868-qfdxri93	89	22	and	and	CC
cord-288868-qfdxri93	89	23	severe	severe	JJ
cord-288868-qfdxri93	89	24	episodes	episode	NNS
cord-288868-qfdxri93	89	25	,	,	,
cord-288868-qfdxri93	89	26	respectively	respectively	RB
cord-288868-qfdxri93	89	27	[	[	-LRB-
cord-288868-qfdxri93	89	28	30	30	CD
cord-288868-qfdxri93	89	29	]	]	-RRB-
cord-288868-qfdxri93	89	30	.	.	.
cord-288868-qfdxri93	90	1	The	the	DT
cord-288868-qfdxri93	90	2	past	past	JJ
cord-288868-qfdxri93	90	3	ten	ten	CD
cord-288868-qfdxri93	90	4	years	year	NNS
cord-288868-qfdxri93	90	5	have	have	VBP
cord-288868-qfdxri93	90	6	changed	change	VBN
cord-288868-qfdxri93	90	7	our	-PRON-	PRP$
cord-288868-qfdxri93	90	8	vision	vision	NN
cord-288868-qfdxri93	90	9	of	of	IN
cord-288868-qfdxri93	90	10	the	the	DT
cord-288868-qfdxri93	90	11	immune	immune	JJ
cord-288868-qfdxri93	90	12	response	response	NN
cord-288868-qfdxri93	90	13	to	to	IN
cord-288868-qfdxri93	90	14	pathogens	pathogen	NNS
cord-288868-qfdxri93	90	15	.	.	.
cord-288868-qfdxri93	91	1	It	-PRON-	PRP
cord-288868-qfdxri93	91	2	has	have	VBZ
cord-288868-qfdxri93	91	3	become	become	VBN
cord-288868-qfdxri93	91	4	clear	clear	JJ
cord-288868-qfdxri93	91	5	that	that	IN
cord-288868-qfdxri93	91	6	the	the	DT
cord-288868-qfdxri93	91	7	degree	degree	NN
cord-288868-qfdxri93	91	8	and	and	CC
cord-288868-qfdxri93	91	9	type	type	NN
cord-288868-qfdxri93	91	10	of	of	IN
cord-288868-qfdxri93	91	11	antigen	antigen	NN
cord-288868-qfdxri93	91	12	-	-	HYPH
cord-288868-qfdxri93	91	13	specific	specific	JJ
cord-288868-qfdxri93	91	14	,	,	,
cord-288868-qfdxri93	91	15	clonal	clonal	JJ
cord-288868-qfdxri93	91	16	B	b	NN
cord-288868-qfdxri93	91	17	and	and	CC
cord-288868-qfdxri93	91	18	T	T	NNP
cord-288868-qfdxri93	91	19	cell	cell	NN
cord-288868-qfdxri93	91	20	responses	response	NNS
cord-288868-qfdxri93	91	21	(	(	-LRB-
cord-288868-qfdxri93	91	22	acquired	acquire	VBN
cord-288868-qfdxri93	91	23	immunity	immunity	NN
cord-288868-qfdxri93	91	24	)	)	-RRB-
cord-288868-qfdxri93	91	25	depend	depend	VBP
cord-288868-qfdxri93	91	26	crucially	crucially	RB
cord-288868-qfdxri93	91	27	on	on	IN
cord-288868-qfdxri93	91	28	the	the	DT
cord-288868-qfdxri93	91	29	prior	prior	JJ
cord-288868-qfdxri93	91	30	action	action	NN
cord-288868-qfdxri93	91	31	of	of	IN
cord-288868-qfdxri93	91	32	a	a	DT
cord-288868-qfdxri93	91	33	more	more	RBR
cord-288868-qfdxri93	91	34	ancient	ancient	JJ
cord-288868-qfdxri93	91	35	system	system	NN
cord-288868-qfdxri93	91	36	of	of	IN
cord-288868-qfdxri93	91	37	pathogen	pathogen	NN
cord-288868-qfdxri93	91	38	detection	detection	NN
cord-288868-qfdxri93	91	39	(	(	-LRB-
cord-288868-qfdxri93	91	40	innate	innate	JJ
cord-288868-qfdxri93	91	41	immunity	immunity	NN
cord-288868-qfdxri93	91	42	)	)	-RRB-
cord-288868-qfdxri93	91	43	.	.	.
cord-288868-qfdxri93	92	1	This	this	DT
cord-288868-qfdxri93	92	2	system	system	NN
cord-288868-qfdxri93	92	3	relies	rely	VBZ
cord-288868-qfdxri93	92	4	on	on	IN
cord-288868-qfdxri93	92	5	the	the	DT
cord-288868-qfdxri93	92	6	activation	activation	NN
cord-288868-qfdxri93	92	7	of	of	IN
cord-288868-qfdxri93	92	8	antigen	antigen	NN
cord-288868-qfdxri93	92	9	-	-	HYPH
cord-288868-qfdxri93	92	10	presenting	present	VBG
cord-288868-qfdxri93	92	11	cells	cell	NNS
cord-288868-qfdxri93	92	12	such	such	JJ
cord-288868-qfdxri93	92	13	as	as	IN
cord-288868-qfdxri93	92	14	dendritic	dendritic	JJ
cord-288868-qfdxri93	92	15	cells	cell	NNS
cord-288868-qfdxri93	92	16	(	(	-LRB-
cord-288868-qfdxri93	92	17	DCs	DCs	NNP
cord-288868-qfdxri93	92	18	)	)	-RRB-
cord-288868-qfdxri93	92	19	upon	upon	IN
cord-288868-qfdxri93	92	20	recognition	recognition	NN
cord-288868-qfdxri93	92	21	of	of	IN
cord-288868-qfdxri93	92	22	patterns	pattern	NNS
cord-288868-qfdxri93	92	23	common	common	JJ
cord-288868-qfdxri93	92	24	to	to	IN
cord-288868-qfdxri93	92	25	viruses	virus	NNS
cord-288868-qfdxri93	92	26	and	and	CC
cord-288868-qfdxri93	92	27	bacteria	bacteria	NNS
cord-288868-qfdxri93	92	28	and	and	CC
cord-288868-qfdxri93	92	29	largely	largely	RB
cord-288868-qfdxri93	92	30	absent	absent	JJ
cord-288868-qfdxri93	92	31	in	in	IN
cord-288868-qfdxri93	92	32	mammals	mammal	NNS
cord-288868-qfdxri93	92	33	.	.	.
cord-288868-qfdxri93	93	1	With	with	IN
cord-288868-qfdxri93	93	2	the	the	DT
cord-288868-qfdxri93	93	3	discovery	discovery	NN
cord-288868-qfdxri93	93	4	of	of	IN
cord-288868-qfdxri93	93	5	the	the	DT
cord-288868-qfdxri93	93	6	involved	involve	VBN
cord-288868-qfdxri93	93	7	pattern	pattern	NN
cord-288868-qfdxri93	93	8	recognition	recognition	NN
cord-288868-qfdxri93	93	9	receptors	receptor	NNS
cord-288868-qfdxri93	93	10	,	,	,
cord-288868-qfdxri93	93	11	among	among	IN
cord-288868-qfdxri93	93	12	which	which	WDT
cord-288868-qfdxri93	93	13	the	the	DT
cord-288868-qfdxri93	93	14	Toll	Toll	NNP
cord-288868-qfdxri93	93	15	-	-	HYPH
cord-288868-qfdxri93	93	16	like	like	JJ
cord-288868-qfdxri93	93	17	receptors	receptor	NNS
cord-288868-qfdxri93	93	18	(	(	-LRB-
cord-288868-qfdxri93	93	19	TLRs	TLRs	NNP
cord-288868-qfdxri93	93	20	)	)	-RRB-
cord-288868-qfdxri93	93	21	represent	represent	VBP
cord-288868-qfdxri93	93	22	an	an	DT
cord-288868-qfdxri93	93	23	important	important	JJ
cord-288868-qfdxri93	93	24	subgroup	subgroup	NN
cord-288868-qfdxri93	93	25	,	,	,
cord-288868-qfdxri93	93	26	immune	immune	NN
cord-288868-qfdxri93	93	27	-	-	HYPH
cord-288868-qfdxri93	93	28	enhancing	enhance	VBG
cord-288868-qfdxri93	93	29	molecules	molecule	NNS
cord-288868-qfdxri93	93	30	or	or	CC
cord-288868-qfdxri93	93	31	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	93	32	can	can	MD
cord-288868-qfdxri93	93	33	no	no	RB
cord-288868-qfdxri93	93	34	longer	longer	RB
cord-288868-qfdxri93	93	35	be	be	VB
cord-288868-qfdxri93	93	36	considered	consider	VBN
cord-288868-qfdxri93	93	37	as	as	IN
cord-288868-qfdxri93	93	38	the	the	DT
cord-288868-qfdxri93	93	39	alchemistic	alchemistic	JJ
cord-288868-qfdxri93	93	40	'	'	POS
cord-288868-qfdxri93	93	41	immunologist	immunologist	NN
cord-288868-qfdxri93	93	42	's	's	POS
cord-288868-qfdxri93	93	43	dirty	dirty	JJ
cord-288868-qfdxri93	93	44	secret	secret	NN
cord-288868-qfdxri93	93	45	'	'	''
cord-288868-qfdxri93	93	46	but	but	CC
cord-288868-qfdxri93	93	47	have	have	VBP
cord-288868-qfdxri93	93	48	become	become	VBN
cord-288868-qfdxri93	93	49	amenable	amenable	JJ
cord-288868-qfdxri93	93	50	to	to	IN
cord-288868-qfdxri93	93	51	rational	rational	JJ
cord-288868-qfdxri93	93	52	design	design	NN
cord-288868-qfdxri93	93	53	,	,	,
cord-288868-qfdxri93	93	54	providing	provide	VBG
cord-288868-qfdxri93	93	55	a	a	DT
cord-288868-qfdxri93	93	56	huge	huge	JJ
cord-288868-qfdxri93	93	57	potential	potential	NN
cord-288868-qfdxri93	93	58	for	for	IN
cord-288868-qfdxri93	93	59	manipulating	manipulate	VBG
cord-288868-qfdxri93	93	60	the	the	DT
cord-288868-qfdxri93	93	61	immune	immune	JJ
cord-288868-qfdxri93	93	62	response	response	NN
cord-288868-qfdxri93	93	63	.	.	.
cord-288868-qfdxri93	94	1	As	as	IN
cord-288868-qfdxri93	94	2	different	different	JJ
cord-288868-qfdxri93	94	3	TLR	TLR	NNP
cord-288868-qfdxri93	94	4	agonists	agonist	NNS
cord-288868-qfdxri93	94	5	elicit	elicit	VBP
cord-288868-qfdxri93	94	6	different	different	JJ
cord-288868-qfdxri93	94	7	types	type	NNS
cord-288868-qfdxri93	94	8	of	of	IN
cord-288868-qfdxri93	94	9	immune	immune	JJ
cord-288868-qfdxri93	94	10	responses	response	NNS
cord-288868-qfdxri93	94	11	(	(	-LRB-
cord-288868-qfdxri93	94	12	reviewed	review	VBN
cord-288868-qfdxri93	94	13	in	in	IN
cord-288868-qfdxri93	94	14	[	[	-LRB-
cord-288868-qfdxri93	94	15	59	59	CD
cord-288868-qfdxri93	94	16	]	]	-RRB-
cord-288868-qfdxri93	94	17	)	)	-RRB-
cord-288868-qfdxri93	94	18	,	,	,
cord-288868-qfdxri93	94	19	future	future	JJ
cord-288868-qfdxri93	94	20	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	94	21	might	may	MD
cord-288868-qfdxri93	94	22	be	be	VB
cord-288868-qfdxri93	94	23	able	able	JJ
cord-288868-qfdxri93	94	24	to	to	TO
cord-288868-qfdxri93	94	25	tailor	tailor	VB
cord-288868-qfdxri93	94	26	the	the	DT
cord-288868-qfdxri93	94	27	immune	immune	JJ
cord-288868-qfdxri93	94	28	response	response	NN
cord-288868-qfdxri93	94	29	so	so	IN
cord-288868-qfdxri93	94	30	that	that	IN
cord-288868-qfdxri93	94	31	optimal	optimal	JJ
cord-288868-qfdxri93	94	32	protection	protection	NN
cord-288868-qfdxri93	94	33	to	to	IN
cord-288868-qfdxri93	94	34	a	a	DT
cord-288868-qfdxri93	94	35	given	give	VBN
cord-288868-qfdxri93	94	36	pathogen	pathogen	NN
cord-288868-qfdxri93	94	37	is	be	VBZ
cord-288868-qfdxri93	94	38	induced	induce	VBN
cord-288868-qfdxri93	94	39	.	.	.
cord-288868-qfdxri93	95	1	In	in	IN
cord-288868-qfdxri93	95	2	fact	fact	NN
cord-288868-qfdxri93	95	3	,	,	,
cord-288868-qfdxri93	95	4	the	the	DT
cord-288868-qfdxri93	95	5	number	number	NN
cord-288868-qfdxri93	95	6	of	of	IN
cord-288868-qfdxri93	95	7	clinical	clinical	JJ
cord-288868-qfdxri93	95	8	trials	trial	NNS
cord-288868-qfdxri93	95	9	involving	involve	VBG
cord-288868-qfdxri93	95	10	TLR	TLR	NNP
cord-288868-qfdxri93	95	11	agonists	agonist	NNS
cord-288868-qfdxri93	95	12	as	as	IN
cord-288868-qfdxri93	95	13	new	new	JJ
cord-288868-qfdxri93	95	14	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	95	15	is	be	VBZ
cord-288868-qfdxri93	95	16	ever	ever	RB
cord-288868-qfdxri93	95	17	increasing	increase	VBG
cord-288868-qfdxri93	95	18	[	[	-LRB-
cord-288868-qfdxri93	95	19	32	32	CD
cord-288868-qfdxri93	95	20	,	,	,
cord-288868-qfdxri93	95	21	33	33	CD
cord-288868-qfdxri93	95	22	]	]	-RRB-
cord-288868-qfdxri93	96	1	(	(	-LRB-
cord-288868-qfdxri93	96	2	Table	table	NN
cord-288868-qfdxri93	96	3	1	1	CD
cord-288868-qfdxri93	96	4	)	)	-RRB-
cord-288868-qfdxri93	96	5	.	.	.
cord-288868-qfdxri93	97	1	The	the	DT
cord-288868-qfdxri93	97	2	adjuvant	adjuvant	JJ
cord-288868-qfdxri93	97	3	function	function	NN
cord-288868-qfdxri93	97	4	of	of	IN
cord-288868-qfdxri93	97	5	nonmethylated	nonmethylated	JJ
cord-288868-qfdxri93	97	6	cytidine	cytidine	JJ
cord-288868-qfdxri93	97	7	-	-	HYPH
cord-288868-qfdxri93	97	8	phosphate	phosphate	NN
cord-288868-qfdxri93	97	9	-	-	HYPH
cord-288868-qfdxri93	97	10	guanosine	guanosine	NN
cord-288868-qfdxri93	97	11	(	(	-LRB-
cord-288868-qfdxri93	97	12	CpG	CpG	NNP
cord-288868-qfdxri93	97	13	)	)	-RRB-
cord-288868-qfdxri93	97	14	sequences	sequence	NNS
cord-288868-qfdxri93	97	15	,	,	,
cord-288868-qfdxri93	97	16	which	which	WDT
cord-288868-qfdxri93	97	17	are	be	VBP
cord-288868-qfdxri93	97	18	frequent	frequent	JJ
cord-288868-qfdxri93	97	19	in	in	IN
cord-288868-qfdxri93	97	20	microbes	microbe	NNS
cord-288868-qfdxri93	97	21	but	but	CC
cord-288868-qfdxri93	97	22	under	under	RB
cord-288868-qfdxri93	97	23	-	-	HYPH
cord-288868-qfdxri93	97	24	represented	represent	VBN
cord-288868-qfdxri93	97	25	in	in	IN
cord-288868-qfdxri93	97	26	humans	human	NNS
cord-288868-qfdxri93	97	27	and	and	CC
cord-288868-qfdxri93	97	28	are	be	VBP
cord-288868-qfdxri93	97	29	agonists	agonist	NNS
cord-288868-qfdxri93	97	30	of	of	IN
cord-288868-qfdxri93	97	31	TLR9	TLR9	NNP
cord-288868-qfdxri93	97	32	,	,	,
cord-288868-qfdxri93	97	33	has	have	VBZ
cord-288868-qfdxri93	97	34	been	be	VBN
cord-288868-qfdxri93	97	35	extensively	extensively	RB
cord-288868-qfdxri93	97	36	demonstrated	demonstrate	VBN
cord-288868-qfdxri93	97	37	in	in	IN
cord-288868-qfdxri93	97	38	animal	animal	NN
cord-288868-qfdxri93	97	39	models	model	NNS
cord-288868-qfdxri93	97	40	[	[	-LRB-
cord-288868-qfdxri93	97	41	34	34	CD
cord-288868-qfdxri93	97	42	]	]	-RRB-
cord-288868-qfdxri93	97	43	and	and	CC
cord-288868-qfdxri93	97	44	is	be	VBZ
cord-288868-qfdxri93	97	45	currently	currently	RB
cord-288868-qfdxri93	97	46	being	be	VBG
cord-288868-qfdxri93	97	47	tested	test	VBN
cord-288868-qfdxri93	97	48	in	in	IN
cord-288868-qfdxri93	97	49	several	several	JJ
cord-288868-qfdxri93	97	50	clinical	clinical	JJ
cord-288868-qfdxri93	97	51	trials	trial	NNS
cord-288868-qfdxri93	97	52	.	.	.
cord-288868-qfdxri93	98	1	When	when	WRB
cord-288868-qfdxri93	98	2	CpGs	CpGs	NNP
cord-288868-qfdxri93	98	3	are	be	VBP
cord-288868-qfdxri93	98	4	coadministered	coadministere	VBN
cord-288868-qfdxri93	98	5	with	with	IN
cord-288868-qfdxri93	98	6	licensed	licensed	JJ
cord-288868-qfdxri93	98	7	HBV	HBV	NNP
cord-288868-qfdxri93	98	8	or	or	CC
cord-288868-qfdxri93	98	9	flu	flu	NN
cord-288868-qfdxri93	98	10	vaccines	vaccine	NNS
cord-288868-qfdxri93	98	11	,	,	,
cord-288868-qfdxri93	98	12	the	the	DT
cord-288868-qfdxri93	98	13	combination	combination	NN
cord-288868-qfdxri93	98	14	leads	lead	VBZ
cord-288868-qfdxri93	98	15	to	to	IN
cord-288868-qfdxri93	98	16	increased	increase	VBN
cord-288868-qfdxri93	98	17	antibody	antibody	NN
cord-288868-qfdxri93	98	18	titers	titer	NNS
cord-288868-qfdxri93	98	19	or	or	CC
cord-288868-qfdxri93	98	20	increased	increase	VBN
cord-288868-qfdxri93	98	21	(	(	-LRB-
cord-288868-qfdxri93	98	22	interferon	interferon	NN
cord-288868-qfdxri93	98	23	-	-	HYPH
cord-288868-qfdxri93	98	24	g	g	NN
cord-288868-qfdxri93	98	25	)	)	-RRB-
cord-288868-qfdxri93	98	26	IFN	IFN	NNP
cord-288868-qfdxri93	98	27	-	-	HYPH
cord-288868-qfdxri93	98	28	g	g	NN
cord-288868-qfdxri93	98	29	production	production	NN
cord-288868-qfdxri93	98	30	,	,	,
cord-288868-qfdxri93	98	31	as	as	IN
cord-288868-qfdxri93	98	32	compared	compare	VBN
cord-288868-qfdxri93	98	33	with	with	IN
cord-288868-qfdxri93	98	34	the	the	DT
cord-288868-qfdxri93	98	35	response	response	NN
cord-288868-qfdxri93	98	36	to	to	IN
cord-288868-qfdxri93	98	37	the	the	DT
cord-288868-qfdxri93	98	38	vaccine	vaccine	NN
cord-288868-qfdxri93	98	39	alone	alone	RB
cord-288868-qfdxri93	98	40	[	[	-LRB-
cord-288868-qfdxri93	98	41	35	35	CD
cord-288868-qfdxri93	98	42	,	,	,
cord-288868-qfdxri93	98	43	36	36	CD
cord-288868-qfdxri93	98	44	]	]	-RRB-
cord-288868-qfdxri93	98	45	.	.	.
cord-288868-qfdxri93	99	1	An	an	DT
cord-288868-qfdxri93	99	2	additional	additional	JJ
cord-288868-qfdxri93	99	3	effect	effect	NN
cord-288868-qfdxri93	99	4	of	of	IN
cord-288868-qfdxri93	99	5	CpG	CpG	NNP
cord-288868-qfdxri93	99	6	oligonucleotides	oligonucleotide	NNS
cord-288868-qfdxri93	99	7	appears	appear	VBZ
cord-288868-qfdxri93	99	8	to	to	TO
cord-288868-qfdxri93	99	9	be	be	VB
cord-288868-qfdxri93	99	10	the	the	DT
cord-288868-qfdxri93	99	11	promotion	promotion	NN
cord-288868-qfdxri93	99	12	of	of	IN
cord-288868-qfdxri93	99	13	affinity	affinity	NN
cord-288868-qfdxri93	99	14	maturation	maturation	NN
cord-288868-qfdxri93	99	15	and	and	CC
cord-288868-qfdxri93	99	16	,	,	,
cord-288868-qfdxri93	99	17	as	as	IN
cord-288868-qfdxri93	99	18	a	a	DT
cord-288868-qfdxri93	99	19	result	result	NN
cord-288868-qfdxri93	99	20	,	,	,
cord-288868-qfdxri93	99	21	a	a	DT
cord-288868-qfdxri93	99	22	higher	high	JJR
cord-288868-qfdxri93	99	23	overall	overall	JJ
cord-288868-qfdxri93	99	24	affinity	affinity	NN
cord-288868-qfdxri93	99	25	of	of	IN
cord-288868-qfdxri93	99	26	the	the	DT
cord-288868-qfdxri93	99	27	vaccine	vaccine	NN
cord-288868-qfdxri93	99	28	-	-	HYPH
cord-288868-qfdxri93	99	29	specific	specific	JJ
cord-288868-qfdxri93	99	30	antibody	antibody	NN
cord-288868-qfdxri93	99	31	pool	pool	NN
cord-288868-qfdxri93	99	32	[	[	-LRB-
cord-288868-qfdxri93	99	33	37	37	CD
cord-288868-qfdxri93	99	34	]	]	-RRB-
cord-288868-qfdxri93	99	35	.	.	.
cord-288868-qfdxri93	100	1	Similarly	similarly	RB
cord-288868-qfdxri93	100	2	,	,	,
cord-288868-qfdxri93	100	3	the	the	DT
cord-288868-qfdxri93	100	4	TLR4	TLR4	NNP
cord-288868-qfdxri93	100	5	agonist	agonist	NN
cord-288868-qfdxri93	100	6	MPL	MPL	NNP
cord-288868-qfdxri93	100	7	has	have	VBZ
cord-288868-qfdxri93	100	8	been	be	VBN
cord-288868-qfdxri93	100	9	shown	show	VBN
cord-288868-qfdxri93	100	10	in	in	IN
cord-288868-qfdxri93	100	11	the	the	DT
cord-288868-qfdxri93	100	12	past	past	NN
cord-288868-qfdxri93	100	13	to	to	TO
cord-288868-qfdxri93	100	14	enhance	enhance	VB
cord-288868-qfdxri93	100	15	the	the	DT
cord-288868-qfdxri93	100	16	immune	immune	JJ
cord-288868-qfdxri93	100	17	response	response	NN
cord-288868-qfdxri93	100	18	to	to	IN
cord-288868-qfdxri93	100	19	HBV	HBV	NNP
cord-288868-qfdxri93	100	20	vaccination	vaccination	NN
cord-288868-qfdxri93	100	21	in	in	IN
cord-288868-qfdxri93	100	22	humans	human	NNS
cord-288868-qfdxri93	100	23	[	[	-LRB-
cord-288868-qfdxri93	100	24	38	38	CD
cord-288868-qfdxri93	100	25	]	]	-RRB-
cord-288868-qfdxri93	100	26	.	.	.
cord-288868-qfdxri93	101	1	In	in	IN
cord-288868-qfdxri93	101	2	addition	addition	NN
cord-288868-qfdxri93	101	3	,	,	,
cord-288868-qfdxri93	101	4	both	both	CC
cord-288868-qfdxri93	101	5	the	the	DT
cord-288868-qfdxri93	101	6	malaria	malaria	NN
cord-288868-qfdxri93	101	7	subunit	subunit	NN
cord-288868-qfdxri93	101	8	vaccine	vaccine	NN
cord-288868-qfdxri93	101	9	mentioned	mention	VBN
cord-288868-qfdxri93	101	10	above	above	IN
cord-288868-qfdxri93	101	11	[	[	-LRB-
cord-288868-qfdxri93	101	12	30	30	CD
cord-288868-qfdxri93	101	13	]	]	-RRB-
cord-288868-qfdxri93	101	14	and	and	CC
cord-288868-qfdxri93	101	15	a	a	DT
cord-288868-qfdxri93	101	16	licensed	licensed	JJ
cord-288868-qfdxri93	101	17	melanoma	melanoma	NN
cord-288868-qfdxri93	101	18	vaccine	vaccine	NN
cord-288868-qfdxri93	101	19	contain	contain	VBP
cord-288868-qfdxri93	101	20	MPL	MPL	NNP
cord-288868-qfdxri93	101	21	.	.	.
cord-288868-qfdxri93	102	1	Another	another	DT
cord-288868-qfdxri93	102	2	experimental	experimental	JJ
cord-288868-qfdxri93	102	3	vaccine	vaccine	NN
cord-288868-qfdxri93	102	4	that	that	WDT
cord-288868-qfdxri93	102	5	includes	include	VBZ
cord-288868-qfdxri93	102	6	a	a	DT
cord-288868-qfdxri93	102	7	TLR2	TLR2	NNP
cord-288868-qfdxri93	102	8	agonist	agonist	NN
cord-288868-qfdxri93	102	9	is	be	VBZ
cord-288868-qfdxri93	102	10	described	describe	VBN
cord-288868-qfdxri93	102	11	below	below	RB
cord-288868-qfdxri93	102	12	,	,	,
cord-288868-qfdxri93	102	13	in	in	IN
cord-288868-qfdxri93	102	14	the	the	DT
cord-288868-qfdxri93	102	15	section	section	NN
cord-288868-qfdxri93	102	16	on	on	IN
cord-288868-qfdxri93	102	17	synthetic	synthetic	JJ
cord-288868-qfdxri93	102	18	vaccines	vaccine	NNS
cord-288868-qfdxri93	102	19	.	.	.
cord-288868-qfdxri93	103	1	Activation	activation	NN
cord-288868-qfdxri93	103	2	of	of	IN
cord-288868-qfdxri93	103	3	DCs	DCs	NNP
cord-288868-qfdxri93	103	4	increases	increase	VBZ
cord-288868-qfdxri93	103	5	their	-PRON-	PRP$
cord-288868-qfdxri93	103	6	ability	ability	NN
cord-288868-qfdxri93	103	7	to	to	TO
cord-288868-qfdxri93	103	8	process	process	VB
cord-288868-qfdxri93	103	9	and	and	CC
cord-288868-qfdxri93	103	10	present	present	VB
cord-288868-qfdxri93	103	11	antigen	antigen	NN
cord-288868-qfdxri93	103	12	and	and	CC
cord-288868-qfdxri93	103	13	to	to	TO
cord-288868-qfdxri93	103	14	attract	attract	VB
cord-288868-qfdxri93	103	15	and	and	CC
cord-288868-qfdxri93	103	16	activate	activate	VB
cord-288868-qfdxri93	103	17	T	T	NNP
cord-288868-qfdxri93	103	18	cells	cell	NNS
cord-288868-qfdxri93	103	19	through	through	IN
cord-288868-qfdxri93	103	20	cytokine	cytokine	JJ
cord-288868-qfdxri93	103	21	secretion	secretion	NN
cord-288868-qfdxri93	103	22	;	;	:
cord-288868-qfdxri93	103	23	consequently	consequently	RB
cord-288868-qfdxri93	103	24	,	,	,
cord-288868-qfdxri93	103	25	several	several	JJ
cord-288868-qfdxri93	103	26	cytokines	cytokine	NNS
cord-288868-qfdxri93	103	27	are	be	VBP
cord-288868-qfdxri93	103	28	414	414	CD
cord-288868-qfdxri93	103	29	Host	host	NN
cord-288868-qfdxri93	103	30	-	-	HYPH
cord-288868-qfdxri93	103	31	pathogen	pathogen	NN
cord-288868-qfdxri93	103	32	interactions	interaction	NNS
cord-288868-qfdxri93	103	33	Table	Table	NNP
cord-288868-qfdxri93	103	34	1	1	CD
cord-288868-qfdxri93	103	35	Human	Human	NNP
cord-288868-qfdxri93	103	36	TLR	TLR	NNP
cord-288868-qfdxri93	103	37	agonists	agonist	NNS
cord-288868-qfdxri93	103	38	used	use	VBN
cord-288868-qfdxri93	103	39	as	as	IN
cord-288868-qfdxri93	103	40	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	103	41	in	in	IN
cord-288868-qfdxri93	103	42	vaccine	vaccine	NN
cord-288868-qfdxri93	103	43	formulations	formulation	NNS
cord-288868-qfdxri93	103	44	in	in	IN
cord-288868-qfdxri93	103	45	clinical	clinical	JJ
cord-288868-qfdxri93	103	46	trials	trial	NNS
cord-288868-qfdxri93	103	47	or	or	CC
cord-288868-qfdxri93	103	48	licensed	license	VBN
cord-288868-qfdxri93	103	49	vaccines	vaccine	NNS
cord-288868-qfdxri93	103	50	a	a	DT
cord-288868-qfdxri93	103	51	.	.	.
cord-288868-qfdxri93	104	1	Known	know	VBN
cord-288868-qfdxri93	104	2	currently	currently	RB
cord-288868-qfdxri93	104	3	being	be	VBG
cord-288868-qfdxri93	104	4	tested	test	VBN
cord-288868-qfdxri93	104	5	for	for	IN
cord-288868-qfdxri93	104	6	their	-PRON-	PRP$
cord-288868-qfdxri93	104	7	adjuvant	adjuvant	NN
cord-288868-qfdxri93	104	8	function	function	NN
cord-288868-qfdxri93	104	9	.	.	.
cord-288868-qfdxri93	105	1	As	as	IN
cord-288868-qfdxri93	105	2	mentioned	mention	VBN
cord-288868-qfdxri93	105	3	above	above	RB
cord-288868-qfdxri93	105	4	,	,	,
cord-288868-qfdxri93	105	5	the	the	DT
cord-288868-qfdxri93	105	6	way	way	NN
cord-288868-qfdxri93	105	7	the	the	DT
cord-288868-qfdxri93	105	8	innate	innate	JJ
cord-288868-qfdxri93	105	9	immune	immune	JJ
cord-288868-qfdxri93	105	10	system	system	NN
cord-288868-qfdxri93	105	11	is	be	VBZ
cord-288868-qfdxri93	105	12	activated	activate	VBN
cord-288868-qfdxri93	105	13	influences	influence	NNS
cord-288868-qfdxri93	105	14	the	the	DT
cord-288868-qfdxri93	105	15	type	type	NN
cord-288868-qfdxri93	105	16	of	of	IN
cord-288868-qfdxri93	105	17	the	the	DT
cord-288868-qfdxri93	105	18	ensuing	ensue	VBG
cord-288868-qfdxri93	105	19	acquired	acquire	VBN
cord-288868-qfdxri93	105	20	immune	immune	JJ
cord-288868-qfdxri93	105	21	response	response	NN
cord-288868-qfdxri93	105	22	.	.	.
cord-288868-qfdxri93	106	1	Martin	Martin	NNP
cord-288868-qfdxri93	106	2	-	-	HYPH
cord-288868-qfdxri93	106	3	Fontecha	Fontecha	NNP
cord-288868-qfdxri93	106	4	et	et	NNP
cord-288868-qfdxri93	106	5	al	al	NNP
cord-288868-qfdxri93	106	6	.	.	.
cord-288868-qfdxri93	107	1	[	[	-LRB-
cord-288868-qfdxri93	107	2	39	39	CD
cord-288868-qfdxri93	107	3	]	]	-RRB-
cord-288868-qfdxri93	107	4	showed	show	VBD
cord-288868-qfdxri93	107	5	that	that	IN
cord-288868-qfdxri93	107	6	the	the	DT
cord-288868-qfdxri93	107	7	ability	ability	NN
cord-288868-qfdxri93	107	8	of	of	IN
cord-288868-qfdxri93	107	9	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	107	10	to	to	TO
cord-288868-qfdxri93	107	11	elicit	elicit	VB
cord-288868-qfdxri93	107	12	a	a	DT
cord-288868-qfdxri93	107	13	Th1	th1	CD
cord-288868-qfdxri93	107	14	type	type	NN
cord-288868-qfdxri93	107	15	response	response	NN
cord-288868-qfdxri93	107	16	depends	depend	VBZ
cord-288868-qfdxri93	107	17	crucially	crucially	RB
cord-288868-qfdxri93	107	18	on	on	IN
cord-288868-qfdxri93	107	19	the	the	DT
cord-288868-qfdxri93	107	20	recruitment	recruitment	NN
cord-288868-qfdxri93	107	21	of	of	IN
cord-288868-qfdxri93	107	22	,	,	,
cord-288868-qfdxri93	107	23	and	and	CC
cord-288868-qfdxri93	107	24	IFN	IFN	NNP
cord-288868-qfdxri93	107	25	-	-	HYPH
cord-288868-qfdxri93	107	26	g	g	NN
cord-288868-qfdxri93	107	27	production	production	NN
cord-288868-qfdxri93	107	28	by	by	IN
cord-288868-qfdxri93	107	29	,	,	,
cord-288868-qfdxri93	107	30	natural	natural	JJ
cord-288868-qfdxri93	107	31	killer	killer	NN
cord-288868-qfdxri93	107	32	(	(	-LRB-
cord-288868-qfdxri93	107	33	NK	NK	NNP
cord-288868-qfdxri93	107	34	)	)	-RRB-
cord-288868-qfdxri93	107	35	cells	cell	NNS
cord-288868-qfdxri93	107	36	,	,	,
cord-288868-qfdxri93	107	37	which	which	WDT
cord-288868-qfdxri93	107	38	indicates	indicate	VBZ
cord-288868-qfdxri93	107	39	a	a	DT
cord-288868-qfdxri93	107	40	possible	possible	JJ
cord-288868-qfdxri93	107	41	mechanism	mechanism	NN
cord-288868-qfdxri93	107	42	of	of	IN
cord-288868-qfdxri93	107	43	the	the	DT
cord-288868-qfdxri93	107	44	way	way	NN
cord-288868-qfdxri93	107	45	in	in	IN
cord-288868-qfdxri93	107	46	which	which	WDT
cord-288868-qfdxri93	107	47	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	107	48	direct	direct	VBP
cord-288868-qfdxri93	107	49	the	the	DT
cord-288868-qfdxri93	107	50	type	type	NN
cord-288868-qfdxri93	107	51	of	of	IN
cord-288868-qfdxri93	107	52	adaptive	adaptive	JJ
cord-288868-qfdxri93	107	53	immune	immune	JJ
cord-288868-qfdxri93	107	54	response	response	NN
cord-288868-qfdxri93	107	55	induced	induce	VBN
cord-288868-qfdxri93	107	56	downstream	downstream	RB
cord-288868-qfdxri93	107	57	.	.	.
cord-288868-qfdxri93	108	1	Another	another	DT
cord-288868-qfdxri93	108	2	vaccine	vaccine	NN
cord-288868-qfdxri93	108	3	approach	approach	NN
cord-288868-qfdxri93	108	4	is	be	VBZ
cord-288868-qfdxri93	108	5	the	the	DT
cord-288868-qfdxri93	108	6	use	use	NN
cord-288868-qfdxri93	108	7	of	of	IN
cord-288868-qfdxri93	108	8	heat	heat	NN
cord-288868-qfdxri93	108	9	shock	shock	NN
cord-288868-qfdxri93	108	10	proteins	protein	NNS
cord-288868-qfdxri93	108	11	,	,	,
cord-288868-qfdxri93	108	12	which	which	WDT
cord-288868-qfdxri93	108	13	bind	bind	VBP
cord-288868-qfdxri93	108	14	specifically	specifically	RB
cord-288868-qfdxri93	108	15	and	and	CC
cord-288868-qfdxri93	108	16	activate	activate	VB
cord-288868-qfdxri93	108	17	dendritic	dendritic	JJ
cord-288868-qfdxri93	108	18	cells	cell	NNS
cord-288868-qfdxri93	108	19	and	and	CC
cord-288868-qfdxri93	108	20	,	,	,
cord-288868-qfdxri93	108	21	because	because	IN
cord-288868-qfdxri93	108	22	they	-PRON-	PRP
cord-288868-qfdxri93	108	23	are	be	VBP
cord-288868-qfdxri93	108	24	loaded	load	VBN
cord-288868-qfdxri93	108	25	with	with	IN
cord-288868-qfdxri93	108	26	endogenous	endogenous	JJ
cord-288868-qfdxri93	108	27	peptides	peptide	NNS
cord-288868-qfdxri93	108	28	,	,	,
cord-288868-qfdxri93	108	29	can	can	MD
cord-288868-qfdxri93	108	30	be	be	VB
cord-288868-qfdxri93	108	31	purified	purify	VBN
cord-288868-qfdxri93	108	32	from	from	IN
cord-288868-qfdxri93	108	33	tumor	tumor	NN
cord-288868-qfdxri93	108	34	cells	cell	NNS
cord-288868-qfdxri93	108	35	and	and	CC
cord-288868-qfdxri93	108	36	function	function	VBP
cord-288868-qfdxri93	108	37	as	as	IN
cord-288868-qfdxri93	108	38	a	a	DT
cord-288868-qfdxri93	108	39	combined	combine	VBN
cord-288868-qfdxri93	108	40	antigen	antigen	NN
cord-288868-qfdxri93	108	41	delivery	delivery	NN
cord-288868-qfdxri93	108	42	system	system	NN
cord-288868-qfdxri93	108	43	and	and	CC
cord-288868-qfdxri93	108	44	adjuvant	adjuvant	JJ
cord-288868-qfdxri93	108	45	[	[	-LRB-
cord-288868-qfdxri93	108	46	40	40	CD
cord-288868-qfdxri93	108	47	]	]	-RRB-
cord-288868-qfdxri93	108	48	.	.	.
cord-288868-qfdxri93	109	1	Because	because	IN
cord-288868-qfdxri93	109	2	the	the	DT
cord-288868-qfdxri93	109	3	main	main	JJ
cord-288868-qfdxri93	109	4	targets	target	NNS
cord-288868-qfdxri93	109	5	of	of	IN
cord-288868-qfdxri93	109	6	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	109	7	are	be	VBP
cord-288868-qfdxri93	109	8	DCs	dc	NNS
cord-288868-qfdxri93	109	9	,	,	,
cord-288868-qfdxri93	109	10	it	-PRON-	PRP
cord-288868-qfdxri93	109	11	is	be	VBZ
cord-288868-qfdxri93	109	12	a	a	DT
cord-288868-qfdxri93	109	13	logical	logical	JJ
cord-288868-qfdxri93	109	14	step	step	NN
cord-288868-qfdxri93	109	15	to	to	TO
cord-288868-qfdxri93	109	16	evaluate	evaluate	VB
cord-288868-qfdxri93	109	17	their	-PRON-	PRP$
cord-288868-qfdxri93	109	18	direct	direct	JJ
cord-288868-qfdxri93	109	19	use	use	NN
cord-288868-qfdxri93	109	20	as	as	IN
cord-288868-qfdxri93	109	21	a	a	DT
cord-288868-qfdxri93	109	22	vaccine	vaccine	NN
cord-288868-qfdxri93	109	23	.	.	.
cord-288868-qfdxri93	110	1	Despite	despite	IN
cord-288868-qfdxri93	110	2	the	the	DT
cord-288868-qfdxri93	110	3	labor	labor	NN
cord-288868-qfdxri93	110	4	-	-	HYPH
cord-288868-qfdxri93	110	5	intensive	intensive	JJ
cord-288868-qfdxri93	110	6	necessity	necessity	NN
cord-288868-qfdxri93	110	7	of	of	IN
cord-288868-qfdxri93	110	8	individual	individual	JJ
cord-288868-qfdxri93	110	9	cell	cell	NN
cord-288868-qfdxri93	110	10	culture	culture	NN
cord-288868-qfdxri93	110	11	for	for	IN
cord-288868-qfdxri93	110	12	each	each	DT
cord-288868-qfdxri93	110	13	patient	patient	NN
cord-288868-qfdxri93	110	14	,	,	,
cord-288868-qfdxri93	110	15	this	this	DT
cord-288868-qfdxri93	110	16	approach	approach	NN
cord-288868-qfdxri93	110	17	can	can	MD
cord-288868-qfdxri93	110	18	be	be	VB
cord-288868-qfdxri93	110	19	attractive	attractive	JJ
cord-288868-qfdxri93	110	20	where	where	WRB
cord-288868-qfdxri93	110	21	other	other	JJ
cord-288868-qfdxri93	110	22	approaches	approach	NNS
cord-288868-qfdxri93	110	23	have	have	VBP
cord-288868-qfdxri93	110	24	failed	fail	VBN
cord-288868-qfdxri93	110	25	,	,	,
cord-288868-qfdxri93	110	26	for	for	IN
cord-288868-qfdxri93	110	27	instance	instance	NN
cord-288868-qfdxri93	110	28	as	as	IN
cord-288868-qfdxri93	110	29	a	a	DT
cord-288868-qfdxri93	110	30	therapeutic	therapeutic	JJ
cord-288868-qfdxri93	110	31	vaccine	vaccine	NN
cord-288868-qfdxri93	110	32	in	in	IN
cord-288868-qfdxri93	110	33	HIV	HIV	NNP
cord-288868-qfdxri93	110	34	or	or	CC
cord-288868-qfdxri93	110	35	cancer	cancer	NN
cord-288868-qfdxri93	110	36	patients	patient	NNS
cord-288868-qfdxri93	110	37	.	.	.
cord-288868-qfdxri93	111	1	When	when	WRB
cord-288868-qfdxri93	111	2	HIV	HIV	NNP
cord-288868-qfdxri93	111	3	patients	patient	NNS
cord-288868-qfdxri93	111	4	were	be	VBD
cord-288868-qfdxri93	111	5	treated	treat	VBN
cord-288868-qfdxri93	111	6	with	with	IN
cord-288868-qfdxri93	111	7	autologous	autologous	JJ
cord-288868-qfdxri93	111	8	DCs	dc	NNS
cord-288868-qfdxri93	111	9	loaded	load	VBN
cord-288868-qfdxri93	111	10	with	with	IN
cord-288868-qfdxri93	111	11	autologous	autologous	JJ
cord-288868-qfdxri93	111	12	,	,	,
cord-288868-qfdxri93	111	13	inactivated	inactivate	VBN
cord-288868-qfdxri93	111	14	HIV	HIV	NNP
cord-288868-qfdxri93	111	15	,	,	,
cord-288868-qfdxri93	111	16	both	both	DT
cord-288868-qfdxri93	111	17	virus	virus	NN
cord-288868-qfdxri93	111	18	-	-	HYPH
cord-288868-qfdxri93	111	19	specific	specific	JJ
cord-288868-qfdxri93	111	20	CD4	CD4	NNP
cord-288868-qfdxri93	111	21	+	+	CC
cord-288868-qfdxri93	111	22	Th1	Th1	NNP
cord-288868-qfdxri93	111	23	and	and	CC
cord-288868-qfdxri93	111	24	CD8	CD8	NNP
cord-288868-qfdxri93	112	1	+	+	CC
cord-288868-qfdxri93	112	2	responses	response	NNS
cord-288868-qfdxri93	112	3	were	be	VBD
cord-288868-qfdxri93	112	4	induced	induce	VBN
cord-288868-qfdxri93	112	5	and	and	CC
cord-288868-qfdxri93	112	6	the	the	DT
cord-288868-qfdxri93	112	7	plasma	plasma	NN
cord-288868-qfdxri93	112	8	viral	viral	JJ
cord-288868-qfdxri93	112	9	loads	load	NNS
cord-288868-qfdxri93	112	10	were	be	VBD
cord-288868-qfdxri93	112	11	reduced	reduce	VBN
cord-288868-qfdxri93	112	12	[	[	-LRB-
cord-288868-qfdxri93	112	13	41	41	CD
cord-288868-qfdxri93	112	14	]	]	-RRB-
cord-288868-qfdxri93	112	15	.	.	.
cord-288868-qfdxri93	113	1	These	these	DT
cord-288868-qfdxri93	113	2	results	result	NNS
cord-288868-qfdxri93	113	3	closely	closely	RB
cord-288868-qfdxri93	113	4	reflect	reflect	VBP
cord-288868-qfdxri93	113	5	previous	previous	JJ
cord-288868-qfdxri93	113	6	findings	finding	NNS
cord-288868-qfdxri93	113	7	from	from	IN
cord-288868-qfdxri93	113	8	a	a	DT
cord-288868-qfdxri93	113	9	similar	similar	JJ
cord-288868-qfdxri93	113	10	vaccination	vaccination	NN
cord-288868-qfdxri93	113	11	of	of	IN
cord-288868-qfdxri93	113	12	rhesus	rhesu	NNS
cord-288868-qfdxri93	113	13	macaques	macaque	NNS
cord-288868-qfdxri93	113	14	[	[	-LRB-
cord-288868-qfdxri93	113	15	42	42	CD
cord-288868-qfdxri93	113	16	]	]	-RRB-
cord-288868-qfdxri93	113	17	,	,	,
cord-288868-qfdxri93	113	18	except	except	IN
cord-288868-qfdxri93	113	19	for	for	IN
cord-288868-qfdxri93	113	20	the	the	DT
cord-288868-qfdxri93	113	21	lack	lack	NN
cord-288868-qfdxri93	113	22	of	of	IN
cord-288868-qfdxri93	113	23	induction	induction	NN
cord-288868-qfdxri93	113	24	of	of	IN
cord-288868-qfdxri93	113	25	neutralizing	neutralize	VBG
cord-288868-qfdxri93	113	26	antibodies	antibody	NNS
cord-288868-qfdxri93	113	27	in	in	IN
cord-288868-qfdxri93	113	28	the	the	DT
cord-288868-qfdxri93	113	29	human	human	JJ
cord-288868-qfdxri93	113	30	study	study	NN
cord-288868-qfdxri93	113	31	.	.	.
cord-288868-qfdxri93	114	1	DC	DC	NNP
cord-288868-qfdxri93	114	2	vaccination	vaccination	NN
cord-288868-qfdxri93	114	3	is	be	VBZ
cord-288868-qfdxri93	114	4	also	also	RB
cord-288868-qfdxri93	114	5	being	be	VBG
cord-288868-qfdxri93	114	6	tested	test	VBN
cord-288868-qfdxri93	114	7	in	in	IN
cord-288868-qfdxri93	114	8	a	a	DT
cord-288868-qfdxri93	114	9	variety	variety	NN
cord-288868-qfdxri93	114	10	of	of	IN
cord-288868-qfdxri93	114	11	cancer	cancer	NN
cord-288868-qfdxri93	114	12	treatments	treatment	NNS
cord-288868-qfdxri93	114	13	[	[	-LRB-
cord-288868-qfdxri93	114	14	43	43	CD
cord-288868-qfdxri93	114	15	]	]	-RRB-
cord-288868-qfdxri93	114	16	.	.	.
cord-288868-qfdxri93	115	1	In	in	IN
cord-288868-qfdxri93	115	2	a	a	DT
cord-288868-qfdxri93	115	3	study	study	NN
cord-288868-qfdxri93	115	4	comparing	compare	VBG
cord-288868-qfdxri93	115	5	the	the	DT
cord-288868-qfdxri93	115	6	immunogenicity	immunogenicity	NN
cord-288868-qfdxri93	115	7	of	of	IN
cord-288868-qfdxri93	115	8	DCs	dc	NNS
cord-288868-qfdxri93	115	9	transfected	transfecte	VBN
cord-288868-qfdxri93	115	10	with	with	IN
cord-288868-qfdxri93	115	11	cytopathic	cytopathic	JJ
cord-288868-qfdxri93	115	12	or	or	CC
cord-288868-qfdxri93	115	13	noncytopathic	noncytopathic	JJ
cord-288868-qfdxri93	115	14	viral	viral	JJ
cord-288868-qfdxri93	115	15	RNA	RNA	NNP
cord-288868-qfdxri93	115	16	,	,	,
cord-288868-qfdxri93	115	17	the	the	DT
cord-288868-qfdxri93	115	18	former	former	JJ
cord-288868-qfdxri93	115	19	regimen	regimen	NN
cord-288868-qfdxri93	115	20	was	be	VBD
cord-288868-qfdxri93	115	21	shown	show	VBN
cord-288868-qfdxri93	115	22	to	to	TO
cord-288868-qfdxri93	115	23	be	be	VB
cord-288868-qfdxri93	115	24	more	more	RBR
cord-288868-qfdxri93	115	25	efficient	efficient	JJ
cord-288868-qfdxri93	115	26	at	at	IN
cord-288868-qfdxri93	115	27	inducing	induce	VBG
cord-288868-qfdxri93	115	28	protective	protective	JJ
cord-288868-qfdxri93	115	29	immune	immune	JJ
cord-288868-qfdxri93	115	30	responses	response	NNS
cord-288868-qfdxri93	115	31	[	[	-LRB-
cord-288868-qfdxri93	115	32	44	44	CD
cord-288868-qfdxri93	115	33	]	]	-RRB-
cord-288868-qfdxri93	115	34	.	.	.
cord-288868-qfdxri93	116	1	This	this	DT
cord-288868-qfdxri93	116	2	suggests	suggest	VBZ
cord-288868-qfdxri93	116	3	that	that	IN
cord-288868-qfdxri93	116	4	reprocessing	reprocess	VBG
cord-288868-qfdxri93	116	5	of	of	IN
cord-288868-qfdxri93	116	6	dying	die	VBG
cord-288868-qfdxri93	116	7	DCs	dc	NNS
cord-288868-qfdxri93	116	8	by	by	IN
cord-288868-qfdxri93	116	9	endogenous	endogenous	JJ
cord-288868-qfdxri93	116	10	antigen	antigen	NN
cord-288868-qfdxri93	116	11	-	-	HYPH
cord-288868-qfdxri93	116	12	presenting	present	VBG
cord-288868-qfdxri93	116	13	cells	cell	NNS
cord-288868-qfdxri93	116	14	enhances	enhance	VBZ
cord-288868-qfdxri93	116	15	immunogenicity	immunogenicity	NN
cord-288868-qfdxri93	116	16	,	,	,
cord-288868-qfdxri93	116	17	either	either	CC
cord-288868-qfdxri93	116	18	through	through	IN
cord-288868-qfdxri93	116	19	additional	additional	JJ
cord-288868-qfdxri93	116	20	danger	danger	NN
cord-288868-qfdxri93	116	21	signals	signal	NNS
cord-288868-qfdxri93	116	22	triggered	trigger	VBN
cord-288868-qfdxri93	116	23	by	by	IN
cord-288868-qfdxri93	116	24	the	the	DT
cord-288868-qfdxri93	116	25	cell	cell	NN
cord-288868-qfdxri93	116	26	damage	damage	NN
cord-288868-qfdxri93	116	27	or	or	CC
cord-288868-qfdxri93	116	28	by	by	IN
cord-288868-qfdxri93	116	29	the	the	DT
cord-288868-qfdxri93	116	30	increased	increase	VBN
cord-288868-qfdxri93	116	31	level	level	NN
cord-288868-qfdxri93	116	32	of	of	IN
cord-288868-qfdxri93	116	33	crosspresentation	crosspresentation	NN
cord-288868-qfdxri93	116	34	by	by	IN
cord-288868-qfdxri93	116	35	endogenous	endogenous	JJ
cord-288868-qfdxri93	116	36	DCs	dc	NNS
cord-288868-qfdxri93	116	37	.	.	.
cord-288868-qfdxri93	117	1	The	the	DT
cord-288868-qfdxri93	117	2	same	same	JJ
cord-288868-qfdxri93	117	3	mechanism	mechanism	NN
cord-288868-qfdxri93	117	4	might	may	MD
cord-288868-qfdxri93	117	5	be	be	VB
cord-288868-qfdxri93	117	6	at	at	IN
cord-288868-qfdxri93	117	7	work	work	NN
cord-288868-qfdxri93	117	8	in	in	IN
cord-288868-qfdxri93	117	9	mycobacterium	mycobacterium	NN
cord-288868-qfdxri93	117	10	infection	infection	NN
cord-288868-qfdxri93	117	11	of	of	IN
cord-288868-qfdxri93	117	12	macrophages	macrophage	NNS
cord-288868-qfdxri93	117	13	,	,	,
cord-288868-qfdxri93	117	14	where	where	WRB
cord-288868-qfdxri93	117	15	apoptosis	apoptosis	NN
cord-288868-qfdxri93	117	16	was	be	VBD
cord-288868-qfdxri93	117	17	shown	show	VBN
cord-288868-qfdxri93	117	18	to	to	TO
cord-288868-qfdxri93	117	19	enhance	enhance	VB
cord-288868-qfdxri93	117	20	crosspresentation	crosspresentation	NN
cord-288868-qfdxri93	117	21	by	by	IN
cord-288868-qfdxri93	117	22	bystander	bystander	NN
cord-288868-qfdxri93	117	23	DCs	DCs	NNP
cord-288868-qfdxri93	117	24	[	[	-LRB-
cord-288868-qfdxri93	117	25	45	45	CD
cord-288868-qfdxri93	117	26	]	]	-RRB-
cord-288868-qfdxri93	117	27	.	.	.
cord-288868-qfdxri93	118	1	Interestingly	interestingly	RB
cord-288868-qfdxri93	118	2	,	,	,
cord-288868-qfdxri93	118	3	following	follow	VBG
cord-288868-qfdxri93	118	4	fractionation	fractionation	NN
cord-288868-qfdxri93	118	5	of	of	IN
cord-288868-qfdxri93	118	6	the	the	DT
cord-288868-qfdxri93	118	7	cytoplasm	cytoplasm	NN
cord-288868-qfdxri93	118	8	of	of	IN
cord-288868-qfdxri93	118	9	dying	die	VBG
cord-288868-qfdxri93	118	10	cells	cell	NNS
cord-288868-qfdxri93	118	11	,	,	,
cord-288868-qfdxri93	118	12	uric	uric	NN
cord-288868-qfdxri93	118	13	acid	acid	NN
cord-288868-qfdxri93	118	14	was	be	VBD
cord-288868-qfdxri93	118	15	identified	identify	VBN
cord-288868-qfdxri93	118	16	as	as	IN
cord-288868-qfdxri93	118	17	a	a	DT
cord-288868-qfdxri93	118	18	highly	highly	RB
cord-288868-qfdxri93	118	19	efficient	efficient	JJ
cord-288868-qfdxri93	118	20	endogenous	endogenous	JJ
cord-288868-qfdxri93	118	21	danger	danger	NN
cord-288868-qfdxri93	118	22	signal	signal	NN
cord-288868-qfdxri93	118	23	that	that	WDT
cord-288868-qfdxri93	118	24	enhances	enhance	VBZ
cord-288868-qfdxri93	118	25	immunogenicity	immunogenicity	NN
cord-288868-qfdxri93	118	26	[	[	-LRB-
cord-288868-qfdxri93	118	27	46	46	CD
cord-288868-qfdxri93	118	28	]	]	-RRB-
cord-288868-qfdxri93	118	29	,	,	,
cord-288868-qfdxri93	118	30	and	and	CC
cord-288868-qfdxri93	118	31	might	may	MD
cord-288868-qfdxri93	118	32	explain	explain	VB
cord-288868-qfdxri93	118	33	the	the	DT
cord-288868-qfdxri93	118	34	above	above	JJ
cord-288868-qfdxri93	118	35	results	result	NNS
cord-288868-qfdxri93	118	36	.	.	.
cord-288868-qfdxri93	119	1	The	the	DT
cord-288868-qfdxri93	119	2	high	high	JJ
cord-288868-qfdxri93	119	3	expectations	expectation	NNS
cord-288868-qfdxri93	119	4	associated	associate	VBN
cord-288868-qfdxri93	119	5	with	with	IN
cord-288868-qfdxri93	119	6	DNA	dna	NN
cord-288868-qfdxri93	119	7	vaccination	vaccination	NN
cord-288868-qfdxri93	119	8	,	,	,
cord-288868-qfdxri93	119	9	as	as	IN
cord-288868-qfdxri93	119	10	a	a	DT
cord-288868-qfdxri93	119	11	result	result	NN
cord-288868-qfdxri93	119	12	of	of	IN
cord-288868-qfdxri93	119	13	promising	promising	JJ
cord-288868-qfdxri93	119	14	data	datum	NNS
cord-288868-qfdxri93	119	15	obtained	obtain	VBN
cord-288868-qfdxri93	119	16	in	in	IN
cord-288868-qfdxri93	119	17	mice	mouse	NNS
cord-288868-qfdxri93	119	18	,	,	,
cord-288868-qfdxri93	119	19	were	be	VBD
cord-288868-qfdxri93	119	20	somewhat	somewhat	RB
cord-288868-qfdxri93	119	21	tempered	temper	VBN
cord-288868-qfdxri93	119	22	by	by	IN
cord-288868-qfdxri93	119	23	disappointing	disappoint	VBG
cord-288868-qfdxri93	119	24	early	early	JJ
cord-288868-qfdxri93	119	25	results	result	NNS
cord-288868-qfdxri93	119	26	when	when	WRB
cord-288868-qfdxri93	119	27	DNA	DNA	NNP
cord-288868-qfdxri93	119	28	was	be	VBD
cord-288868-qfdxri93	119	29	tested	test	VBN
cord-288868-qfdxri93	119	30	as	as	IN
cord-288868-qfdxri93	119	31	a	a	DT
cord-288868-qfdxri93	119	32	vaccine	vaccine	NN
cord-288868-qfdxri93	119	33	in	in	IN
cord-288868-qfdxri93	119	34	humans	human	NNS
cord-288868-qfdxri93	119	35	.	.	.
cord-288868-qfdxri93	120	1	Therefore	therefore	RB
cord-288868-qfdxri93	120	2	,	,	,
cord-288868-qfdxri93	120	3	the	the	DT
cord-288868-qfdxri93	120	4	latest	late	JJS
cord-288868-qfdxri93	120	5	generation	generation	NN
cord-288868-qfdxri93	120	6	of	of	IN
cord-288868-qfdxri93	120	7	DNA	dna	NN
cord-288868-qfdxri93	120	8	vaccines	vaccine	NNS
cord-288868-qfdxri93	120	9	rely	rely	VBP
cord-288868-qfdxri93	120	10	on	on	IN
cord-288868-qfdxri93	120	11	improved	improved	JJ
cord-288868-qfdxri93	120	12	delivery	delivery	NN
cord-288868-qfdxri93	120	13	either	either	CC
cord-288868-qfdxri93	120	14	through	through	IN
cord-288868-qfdxri93	120	15	use	use	NN
cord-288868-qfdxri93	120	16	of	of	IN
cord-288868-qfdxri93	120	17	microparticles	microparticle	NNS
cord-288868-qfdxri93	120	18	[	[	-LRB-
cord-288868-qfdxri93	120	19	47	47	CD
cord-288868-qfdxri93	120	20	]	]	-RRB-
cord-288868-qfdxri93	120	21	or	or	CC
cord-288868-qfdxri93	120	22	through	through	IN
cord-288868-qfdxri93	120	23	viral	viral	JJ
cord-288868-qfdxri93	120	24	vectors	vector	NNS
cord-288868-qfdxri93	120	25	.	.	.
cord-288868-qfdxri93	121	1	A	a	DT
cord-288868-qfdxri93	121	2	particularly	particularly	RB
cord-288868-qfdxri93	121	3	promising	promising	JJ
cord-288868-qfdxri93	121	4	approach	approach	NN
cord-288868-qfdxri93	121	5	is	be	VBZ
cord-288868-qfdxri93	121	6	a	a	DT
cord-288868-qfdxri93	121	7	heterologous	heterologous	JJ
cord-288868-qfdxri93	121	8	prime	prime	JJ
cord-288868-qfdxri93	121	9	-	-	HYPH
cord-288868-qfdxri93	121	10	boost	boost	NN
cord-288868-qfdxri93	121	11	strategy	strategy	NN
cord-288868-qfdxri93	121	12	,	,	,
cord-288868-qfdxri93	121	13	where	where	WRB
cord-288868-qfdxri93	121	14	adminis	adminis	NNP
cord-288868-qfdxri93	121	15	-	-	HYPH
cord-288868-qfdxri93	121	16	tration	tration	NN
cord-288868-qfdxri93	121	17	of	of	IN
cord-288868-qfdxri93	121	18	plasmid	plasmid	NN
cord-288868-qfdxri93	121	19	DNA	DNA	NNP
cord-288868-qfdxri93	121	20	is	be	VBZ
cord-288868-qfdxri93	121	21	followed	follow	VBN
cord-288868-qfdxri93	121	22	by	by	IN
cord-288868-qfdxri93	121	23	recombinant	recombinant	JJ
cord-288868-qfdxri93	121	24	virus	virus	NN
cord-288868-qfdxri93	121	25	(	(	-LRB-
cord-288868-qfdxri93	121	26	modified	modify	VBN
cord-288868-qfdxri93	121	27	vaccinia	vaccinia	NN
cord-288868-qfdxri93	121	28	virus	virus	NN
cord-288868-qfdxri93	121	29	Ankara	Ankara	NNP
cord-288868-qfdxri93	121	30	[	[	-LRB-
cord-288868-qfdxri93	121	31	MVA	MVA	NNP
cord-288868-qfdxri93	121	32	]	]	-RRB-
cord-288868-qfdxri93	121	33	or	or	CC
cord-288868-qfdxri93	121	34	adenovirus	adenovirus	NN
cord-288868-qfdxri93	121	35	)	)	-RRB-
cord-288868-qfdxri93	121	36	expressing	express	VBG
cord-288868-qfdxri93	121	37	the	the	DT
cord-288868-qfdxri93	121	38	same	same	JJ
cord-288868-qfdxri93	121	39	antigen	antigen	NN
cord-288868-qfdxri93	121	40	.	.	.
cord-288868-qfdxri93	122	1	This	this	DT
cord-288868-qfdxri93	122	2	regimen	regimen	NN
cord-288868-qfdxri93	122	3	induced	induce	VBD
cord-288868-qfdxri93	122	4	strong	strong	JJ
cord-288868-qfdxri93	122	5	T	t	NN
cord-288868-qfdxri93	122	6	cell	cell	NN
cord-288868-qfdxri93	122	7	responses	response	NNS
cord-288868-qfdxri93	122	8	against	against	IN
cord-288868-qfdxri93	122	9	P.	P.	NNP
cord-288868-qfdxri93	122	10	falciparum	falciparum	NN
cord-288868-qfdxri93	122	11	in	in	IN
cord-288868-qfdxri93	122	12	naïve	naïve	JJ
cord-288868-qfdxri93	122	13	adults	adult	NNS
cord-288868-qfdxri93	122	14	[	[	-LRB-
cord-288868-qfdxri93	122	15	48	48	CD
cord-288868-qfdxri93	122	16	]	]	-RRB-
cord-288868-qfdxri93	122	17	and	and	CC
cord-288868-qfdxri93	122	18	enhanced	enhance	VBD
cord-288868-qfdxri93	122	19	the	the	DT
cord-288868-qfdxri93	122	20	response	response	NN
cord-288868-qfdxri93	122	21	in	in	IN
cord-288868-qfdxri93	122	22	Gambian	gambian	JJ
cord-288868-qfdxri93	122	23	men	man	NNS
cord-288868-qfdxri93	122	24	who	who	WP
cord-288868-qfdxri93	122	25	are	be	VBP
cord-288868-qfdxri93	122	26	constantly	constantly	RB
cord-288868-qfdxri93	122	27	exposed	expose	VBN
cord-288868-qfdxri93	122	28	to	to	IN
cord-288868-qfdxri93	122	29	P.	P.	NNP
cord-288868-qfdxri93	122	30	falciparum	falciparum	NN
cord-288868-qfdxri93	122	31	[	[	-LRB-
cord-288868-qfdxri93	122	32	49	49	CD
cord-288868-qfdxri93	122	33	]	]	-RRB-
cord-288868-qfdxri93	122	34	.	.	.
cord-288868-qfdxri93	123	1	Although	although	IN
cord-288868-qfdxri93	123	2	partial	partial	JJ
cord-288868-qfdxri93	123	3	protection	protection	NN
cord-288868-qfdxri93	123	4	against	against	IN
cord-288868-qfdxri93	123	5	challenge	challenge	NN
cord-288868-qfdxri93	123	6	with	with	IN
cord-288868-qfdxri93	123	7	a	a	DT
cord-288868-qfdxri93	123	8	different	different	JJ
cord-288868-qfdxri93	123	9	P.	P.	NNP
cord-288868-qfdxri93	123	10	falciparum	falciparum	NN
cord-288868-qfdxri93	123	11	strain	strain	NN
cord-288868-qfdxri93	123	12	was	be	VBD
cord-288868-qfdxri93	123	13	observed	observe	VBN
cord-288868-qfdxri93	123	14	,	,	,
cord-288868-qfdxri93	123	15	no	no	DT
cord-288868-qfdxri93	123	16	significant	significant	JJ
cord-288868-qfdxri93	123	17	differences	difference	NNS
cord-288868-qfdxri93	123	18	in	in	IN
cord-288868-qfdxri93	123	19	the	the	DT
cord-288868-qfdxri93	123	20	infection	infection	NN
cord-288868-qfdxri93	123	21	rate	rate	NN
cord-288868-qfdxri93	123	22	was	be	VBD
cord-288868-qfdxri93	123	23	found	find	VBN
cord-288868-qfdxri93	123	24	in	in	IN
cord-288868-qfdxri93	123	25	the	the	DT
cord-288868-qfdxri93	123	26	Gambian	gambian	JJ
cord-288868-qfdxri93	123	27	trial	trial	NN
cord-288868-qfdxri93	123	28	[	[	-LRB-
cord-288868-qfdxri93	123	29	50	50	CD
cord-288868-qfdxri93	123	30	]	]	-RRB-
cord-288868-qfdxri93	123	31	.	.	.
cord-288868-qfdxri93	124	1	In	in	IN
cord-288868-qfdxri93	124	2	spite	spite	NN
cord-288868-qfdxri93	124	3	of	of	IN
cord-288868-qfdxri93	124	4	these	these	DT
cord-288868-qfdxri93	124	5	setbacks	setback	NNS
cord-288868-qfdxri93	124	6	,	,	,
cord-288868-qfdxri93	124	7	a	a	DT
cord-288868-qfdxri93	124	8	very	very	RB
cord-288868-qfdxri93	124	9	similar	similar	JJ
cord-288868-qfdxri93	124	10	regimen	regimen	NN
cord-288868-qfdxri93	124	11	has	have	VBZ
cord-288868-qfdxri93	124	12	been	be	VBN
cord-288868-qfdxri93	124	13	shown	show	VBN
cord-288868-qfdxri93	124	14	also	also	RB
cord-288868-qfdxri93	124	15	to	to	TO
cord-288868-qfdxri93	124	16	be	be	VB
cord-288868-qfdxri93	124	17	highly	highly	RB
cord-288868-qfdxri93	124	18	immunogenic	immunogenic	JJ
cord-288868-qfdxri93	124	19	against	against	IN
cord-288868-qfdxri93	124	20	HBV	HBV	NNP
cord-288868-qfdxri93	124	21	,	,	,
cord-288868-qfdxri93	124	22	tuberculosis	tuberculosis	NN
cord-288868-qfdxri93	124	23	and	and	CC
cord-288868-qfdxri93	124	24	HIV	HIV	NNP
cord-288868-qfdxri93	124	25	,	,	,
cord-288868-qfdxri93	124	26	and	and	CC
cord-288868-qfdxri93	124	27	vaccination	vaccination	NN
cord-288868-qfdxri93	124	28	only	only	RB
cord-288868-qfdxri93	124	29	with	with	IN
cord-288868-qfdxri93	124	30	MVA	MVA	NNP
cord-288868-qfdxri93	124	31	expressing	express	VBG
cord-288868-qfdxri93	124	32	the	the	DT
cord-288868-qfdxri93	124	33	mycobacterium	mycobacterium	NN
cord-288868-qfdxri93	124	34	A85	A85	NNP
cord-288868-qfdxri93	124	35	antigen	antigen	NN
cord-288868-qfdxri93	124	36	elicited	elicit	VBD
cord-288868-qfdxri93	124	37	strong	strong	JJ
cord-288868-qfdxri93	124	38	T	t	NN
cord-288868-qfdxri93	124	39	cell	cell	NN
cord-288868-qfdxri93	124	40	responses	response	NNS
cord-288868-qfdxri93	124	41	[	[	-LRB-
cord-288868-qfdxri93	124	42	51	51	CD
cord-288868-qfdxri93	124	43	]	]	-RRB-
cord-288868-qfdxri93	124	44	.	.	.
cord-288868-qfdxri93	125	1	Because	because	IN
cord-288868-qfdxri93	125	2	the	the	DT
cord-288868-qfdxri93	125	3	induction	induction	NN
cord-288868-qfdxri93	125	4	of	of	IN
cord-288868-qfdxri93	125	5	T	T	NNP
cord-288868-qfdxri93	125	6	cells	cell	NNS
cord-288868-qfdxri93	125	7	is	be	VBZ
cord-288868-qfdxri93	125	8	considered	consider	VBN
cord-288868-qfdxri93	125	9	to	to	TO
cord-288868-qfdxri93	125	10	be	be	VB
cord-288868-qfdxri93	125	11	crucial	crucial	JJ
cord-288868-qfdxri93	125	12	in	in	IN
cord-288868-qfdxri93	125	13	anti	anti	JJ
cord-288868-qfdxri93	125	14	-	-	JJ
cord-288868-qfdxri93	125	15	tumor	tumor	JJ
cord-288868-qfdxri93	125	16	immune	immune	JJ
cord-288868-qfdxri93	125	17	responses	response	NNS
cord-288868-qfdxri93	125	18	,	,	,
cord-288868-qfdxri93	125	19	a	a	DT
cord-288868-qfdxri93	125	20	huge	huge	JJ
cord-288868-qfdxri93	125	21	number	number	NN
cord-288868-qfdxri93	125	22	of	of	IN
cord-288868-qfdxri93	125	23	trials	trial	NNS
cord-288868-qfdxri93	125	24	are	be	VBP
cord-288868-qfdxri93	125	25	presently	presently	RB
cord-288868-qfdxri93	125	26	being	be	VBG
cord-288868-qfdxri93	125	27	conducted	conduct	VBN
cord-288868-qfdxri93	125	28	to	to	TO
cord-288868-qfdxri93	125	29	test	test	VB
cord-288868-qfdxri93	125	30	DNA	dna	NN
cord-288868-qfdxri93	125	31	vaccination	vaccination	NN
cord-288868-qfdxri93	125	32	regimens	regimen	NNS
cord-288868-qfdxri93	125	33	for	for	IN
cord-288868-qfdxri93	125	34	anticancer	anticancer	JJ
cord-288868-qfdxri93	125	35	treatment	treatment	NN
cord-288868-qfdxri93	125	36	[	[	-LRB-
cord-288868-qfdxri93	125	37	52	52	CD
cord-288868-qfdxri93	125	38	,	,	,
cord-288868-qfdxri93	125	39	53	53	CD
cord-288868-qfdxri93	125	40	]	]	-RRB-
cord-288868-qfdxri93	125	41	.	.	.
cord-288868-qfdxri93	126	1	When	when	WRB
cord-288868-qfdxri93	126	2	viral	viral	JJ
cord-288868-qfdxri93	126	3	vehicles	vehicle	NNS
cord-288868-qfdxri93	126	4	(	(	-LRB-
cord-288868-qfdxri93	126	5	vaccinia	vaccinia	NN
cord-288868-qfdxri93	126	6	or	or	CC
cord-288868-qfdxri93	126	7	adenovirus	adenovirus	NN
cord-288868-qfdxri93	126	8	)	)	-RRB-
cord-288868-qfdxri93	126	9	were	be	VBD
cord-288868-qfdxri93	126	10	compared	compare	VBN
cord-288868-qfdxri93	126	11	with	with	IN
cord-288868-qfdxri93	126	12	loaded	loaded	JJ
cord-288868-qfdxri93	126	13	DCs	dc	NNS
cord-288868-qfdxri93	126	14	in	in	IN
cord-288868-qfdxri93	126	15	terms	term	NNS
cord-288868-qfdxri93	126	16	of	of	IN
cord-288868-qfdxri93	126	17	their	-PRON-	PRP$
cord-288868-qfdxri93	126	18	ability	ability	NN
cord-288868-qfdxri93	126	19	to	to	TO
cord-288868-qfdxri93	126	20	overcome	overcome	VB
cord-288868-qfdxri93	126	21	established	established	JJ
cord-288868-qfdxri93	126	22	tolerance	tolerance	NN
cord-288868-qfdxri93	126	23	and	and	CC
cord-288868-qfdxri93	126	24	induce	induce	VB
cord-288868-qfdxri93	126	25	immune	immune	JJ
cord-288868-qfdxri93	126	26	responses	response	NNS
cord-288868-qfdxri93	126	27	in	in	IN
cord-288868-qfdxri93	126	28	a	a	DT
cord-288868-qfdxri93	126	29	transgenic	transgenic	JJ
cord-288868-qfdxri93	126	30	mouse	mouse	NN
cord-288868-qfdxri93	126	31	model	model	NN
cord-288868-qfdxri93	126	32	,	,	,
cord-288868-qfdxri93	126	33	the	the	DT
cord-288868-qfdxri93	126	34	viral	viral	JJ
cord-288868-qfdxri93	126	35	formulations	formulation	NNS
cord-288868-qfdxri93	126	36	were	be	VBD
cord-288868-qfdxri93	126	37	able	able	JJ
cord-288868-qfdxri93	126	38	to	to	TO
cord-288868-qfdxri93	126	39	do	do	VB
cord-288868-qfdxri93	126	40	so	so	RB
cord-288868-qfdxri93	126	41	,	,	,
cord-288868-qfdxri93	126	42	whereas	whereas	IN
cord-288868-qfdxri93	126	43	DCs	DCs	NNP
cord-288868-qfdxri93	126	44	required	require	VBD
cord-288868-qfdxri93	126	45	repeated	repeat	VBD
cord-288868-qfdxri93	126	46	administration	administration	NN
cord-288868-qfdxri93	126	47	of	of	IN
cord-288868-qfdxri93	126	48	TLR	TLR	NNP
cord-288868-qfdxri93	126	49	agonists	agonist	NNS
cord-288868-qfdxri93	126	50	or	or	CC
cord-288868-qfdxri93	126	51	irrelevant	irrelevant	JJ
cord-288868-qfdxri93	126	52	virus	virus	NN
cord-288868-qfdxri93	126	53	,	,	,
cord-288868-qfdxri93	126	54	or	or	CC
cord-288868-qfdxri93	126	55	removal	removal	NN
cord-288868-qfdxri93	126	56	of	of	IN
cord-288868-qfdxri93	126	57	suppressive	suppressive	JJ
cord-288868-qfdxri93	126	58	CD4	CD4	NNP
cord-288868-qfdxri93	126	59	+	+	CC
cord-288868-qfdxri93	126	60	CD25	CD25	NNP
cord-288868-qfdxri93	126	61	+	+	CC
cord-288868-qfdxri93	126	62	Treg	Treg	NNP
cord-288868-qfdxri93	126	63	cells	cell	NNS
cord-288868-qfdxri93	126	64	[	[	-LRB-
cord-288868-qfdxri93	126	65	54	54	CD
cord-288868-qfdxri93	126	66	]	]	-RRB-
cord-288868-qfdxri93	126	67	.	.	.
cord-288868-qfdxri93	127	1	Such	such	JJ
cord-288868-qfdxri93	127	2	models	model	NNS
cord-288868-qfdxri93	127	3	of	of	IN
cord-288868-qfdxri93	127	4	established	establish	VBN
cord-288868-qfdxri93	127	5	tolerance	tolerance	NN
cord-288868-qfdxri93	127	6	might	may	MD
cord-288868-qfdxri93	127	7	prove	prove	VB
cord-288868-qfdxri93	127	8	useful	useful	JJ
cord-288868-qfdxri93	127	9	for	for	IN
cord-288868-qfdxri93	127	10	testing	test	VBG
cord-288868-qfdxri93	127	11	the	the	DT
cord-288868-qfdxri93	127	12	success	success	NN
cord-288868-qfdxri93	127	13	of	of	IN
cord-288868-qfdxri93	127	14	vaccines	vaccine	NNS
cord-288868-qfdxri93	127	15	in	in	IN
cord-288868-qfdxri93	127	16	the	the	DT
cord-288868-qfdxri93	127	17	face	face	NN
cord-288868-qfdxri93	127	18	of	of	IN
cord-288868-qfdxri93	127	19	long	long	JJ
cord-288868-qfdxri93	127	20	-	-	HYPH
cord-288868-qfdxri93	127	21	term	term	NN
cord-288868-qfdxri93	127	22	antigen	antigen	NN
cord-288868-qfdxri93	127	23	exposure	exposure	NN
cord-288868-qfdxri93	127	24	,	,	,
cord-288868-qfdxri93	127	25	as	as	IN
cord-288868-qfdxri93	127	26	in	in	IN
cord-288868-qfdxri93	127	27	the	the	DT
cord-288868-qfdxri93	127	28	case	case	NN
cord-288868-qfdxri93	127	29	of	of	IN
cord-288868-qfdxri93	127	30	cancer	cancer	NN
cord-288868-qfdxri93	127	31	or	or	CC
cord-288868-qfdxri93	127	32	chronic	chronic	JJ
cord-288868-qfdxri93	127	33	diseases	disease	NNS
cord-288868-qfdxri93	127	34	.	.	.
cord-288868-qfdxri93	128	1	Two	two	CD
cord-288868-qfdxri93	128	2	studies	study	NNS
cord-288868-qfdxri93	128	3	analyzed	analyze	VBN
cord-288868-qfdxri93	128	4	in	in	IN
cord-288868-qfdxri93	128	5	detail	detail	NN
cord-288868-qfdxri93	128	6	the	the	DT
cord-288868-qfdxri93	128	7	T	T	NNP
cord-288868-qfdxri93	128	8	cell	cell	NN
cord-288868-qfdxri93	128	9	response	response	NN
cord-288868-qfdxri93	128	10	after	after	IN
cord-288868-qfdxri93	128	11	vaccination	vaccination	NN
cord-288868-qfdxri93	128	12	with	with	IN
cord-288868-qfdxri93	128	13	a	a	DT
cord-288868-qfdxri93	128	14	recombinant	recombinant	JJ
cord-288868-qfdxri93	128	15	canarypox	canarypox	NN
cord-288868-qfdxri93	128	16	virus	virus	NN
cord-288868-qfdxri93	128	17	expressing	express	VBG
cord-288868-qfdxri93	128	18	melanoma	melanoma	NN
cord-288868-qfdxri93	128	19	-	-	HYPH
cord-288868-qfdxri93	128	20	specific	specific	JJ
cord-288868-qfdxri93	128	21	T	t	NN
cord-288868-qfdxri93	128	22	cell	cell	NN
cord-288868-qfdxri93	128	23	epitopes	epitope	NNS
cord-288868-qfdxri93	128	24	[	[	-LRB-
cord-288868-qfdxri93	128	25	55	55	CD
cord-288868-qfdxri93	128	26	,	,	,
cord-288868-qfdxri93	128	27	56	56	CD
cord-288868-qfdxri93	128	28	]	]	-RRB-
cord-288868-qfdxri93	128	29	.	.	.
cord-288868-qfdxri93	129	1	Focusing	focus	VBG
cord-288868-qfdxri93	129	2	on	on	IN
cord-288868-qfdxri93	129	3	the	the	DT
cord-288868-qfdxri93	129	4	blood	blood	NN
cord-288868-qfdxri93	129	5	and	and	CC
cord-288868-qfdxri93	129	6	metastases	metastasis	NNS
cord-288868-qfdxri93	129	7	from	from	IN
cord-288868-qfdxri93	129	8	a	a	DT
cord-288868-qfdxri93	129	9	patient	patient	NN
cord-288868-qfdxri93	129	10	with	with	IN
cord-288868-qfdxri93	129	11	complete	complete	JJ
cord-288868-qfdxri93	129	12	regression	regression	NN
cord-288868-qfdxri93	129	13	,	,	,
cord-288868-qfdxri93	129	14	these	these	DT
cord-288868-qfdxri93	129	15	studies	study	NNS
cord-288868-qfdxri93	129	16	reconfirmed	reconfirm	VBD
cord-288868-qfdxri93	129	17	earlier	early	JJR
cord-288868-qfdxri93	129	18	observations	observation	NNS
cord-288868-qfdxri93	129	19	that	that	IN
cord-288868-qfdxri93	129	20	the	the	DT
cord-288868-qfdxri93	129	21	frequency	frequency	NN
cord-288868-qfdxri93	129	22	of	of	IN
cord-288868-qfdxri93	129	23	anti	anti	JJ
cord-288868-qfdxri93	129	24	-	-	JJ
cord-288868-qfdxri93	129	25	tumor	tumor	JJ
cord-288868-qfdxri93	129	26	T	t	NN
cord-288868-qfdxri93	129	27	cells	cell	NNS
cord-288868-qfdxri93	129	28	can	can	MD
cord-288868-qfdxri93	129	29	be	be	VB
cord-288868-qfdxri93	129	30	relatively	relatively	RB
cord-288868-qfdxri93	129	31	high	high	JJ
cord-288868-qfdxri93	129	32	.	.	.
cord-288868-qfdxri93	130	1	Although	although	IN
cord-288868-qfdxri93	130	2	vaccination	vaccination	NN
cord-288868-qfdxri93	130	3	leads	lead	VBZ
cord-288868-qfdxri93	130	4	to	to	IN
cord-288868-qfdxri93	130	5	a	a	DT
cord-288868-qfdxri93	130	6	slight	slight	JJ
cord-288868-qfdxri93	130	7	increase	increase	NN
cord-288868-qfdxri93	130	8	in	in	IN
cord-288868-qfdxri93	130	9	vaccine	vaccine	NN
cord-288868-qfdxri93	130	10	-	-	HYPH
cord-288868-qfdxri93	130	11	specific	specific	JJ
cord-288868-qfdxri93	130	12	T	t	NN
cord-288868-qfdxri93	130	13	cells	cell	NNS
cord-288868-qfdxri93	130	14	,	,	,
cord-288868-qfdxri93	130	15	these	these	DT
cord-288868-qfdxri93	130	16	remain	remain	VBP
cord-288868-qfdxri93	130	17	only	only	RB
cord-288868-qfdxri93	130	18	a	a	DT
cord-288868-qfdxri93	130	19	small	small	JJ
cord-288868-qfdxri93	130	20	fraction	fraction	NN
cord-288868-qfdxri93	130	21	of	of	IN
cord-288868-qfdxri93	130	22	total	total	JJ
cord-288868-qfdxri93	130	23	anti	anti	JJ
cord-288868-qfdxri93	130	24	-	-	JJ
cord-288868-qfdxri93	130	25	tumor	tumor	JJ
cord-288868-qfdxri93	130	26	T	t	NN
cord-288868-qfdxri93	130	27	cells	cell	NNS
cord-288868-qfdxri93	130	28	.	.	.
cord-288868-qfdxri93	131	1	By	by	IN
cord-288868-qfdxri93	131	2	contrast	contrast	NN
cord-288868-qfdxri93	131	3	,	,	,
cord-288868-qfdxri93	131	4	T	t	NN
cord-288868-qfdxri93	131	5	cells	cell	NNS
cord-288868-qfdxri93	131	6	directed	direct	VBN
cord-288868-qfdxri93	131	7	against	against	IN
cord-288868-qfdxri93	131	8	epitopes	epitope	NNS
cord-288868-qfdxri93	131	9	not	not	RB
cord-288868-qfdxri93	131	10	contained	contain	VBN
cord-288868-qfdxri93	131	11	in	in	IN
cord-288868-qfdxri93	131	12	the	the	DT
cord-288868-qfdxri93	131	13	vaccine	vaccine	NN
cord-288868-qfdxri93	131	14	represent	represent	VBP
cord-288868-qfdxri93	131	15	the	the	DT
cord-288868-qfdxri93	131	16	vast	vast	JJ
cord-288868-qfdxri93	131	17	majority	majority	NN
cord-288868-qfdxri93	131	18	of	of	IN
cord-288868-qfdxri93	131	19	anti	anti	JJ
cord-288868-qfdxri93	131	20	-	-	JJ
cord-288868-qfdxri93	131	21	tumor	tumor	JJ
cord-288868-qfdxri93	131	22	cells	cell	NNS
cord-288868-qfdxri93	131	23	,	,	,
cord-288868-qfdxri93	131	24	and	and	CC
cord-288868-qfdxri93	131	25	their	-PRON-	PRP$
cord-288868-qfdxri93	131	26	frequency	frequency	NN
cord-288868-qfdxri93	131	27	increases	increase	VBZ
cord-288868-qfdxri93	131	28	both	both	DT
cord-288868-qfdxri93	131	29	in	in	IN
cord-288868-qfdxri93	131	30	the	the	DT
cord-288868-qfdxri93	131	31	blood	blood	NN
cord-288868-qfdxri93	131	32	and	and	CC
cord-288868-qfdxri93	131	33	in	in	IN
cord-288868-qfdxri93	131	34	metastases	metastasis	NNS
cord-288868-qfdxri93	131	35	.	.	.
cord-288868-qfdxri93	132	1	Thus	thus	RB
cord-288868-qfdxri93	132	2	,	,	,
cord-288868-qfdxri93	132	3	it	-PRON-	PRP
cord-288868-qfdxri93	132	4	appears	appear	VBZ
cord-288868-qfdxri93	132	5	that	that	IN
cord-288868-qfdxri93	132	6	with	with	IN
cord-288868-qfdxri93	132	7	the	the	DT
cord-288868-qfdxri93	132	8	appropriate	appropriate	JJ
cord-288868-qfdxri93	132	9	vaccine	vaccine	NN
cord-288868-qfdxri93	132	10	regimen	regimen	NN
cord-288868-qfdxri93	132	11	,	,	,
cord-288868-qfdxri93	132	12	the	the	DT
cord-288868-qfdxri93	132	13	inefficiency	inefficiency	NN
cord-288868-qfdxri93	132	14	of	of	IN
cord-288868-qfdxri93	132	15	pre	pre	JJ
cord-288868-qfdxri93	132	16	-	-	JJ
cord-288868-qfdxri93	132	17	existing	existing	JJ
cord-288868-qfdxri93	132	18	specific	specific	JJ
cord-288868-qfdxri93	132	19	T	t	NN
cord-288868-qfdxri93	132	20	cells	cell	NNS
cord-288868-qfdxri93	132	21	to	to	TO
cord-288868-qfdxri93	132	22	combat	combat	VB
cord-288868-qfdxri93	132	23	the	the	DT
cord-288868-qfdxri93	132	24	tumor	tumor	NN
cord-288868-qfdxri93	132	25	was	be	VBD
cord-288868-qfdxri93	132	26	reversed	reverse	VBN
cord-288868-qfdxri93	132	27	in	in	IN
cord-288868-qfdxri93	132	28	an	an	DT
cord-288868-qfdxri93	132	29	indirect	indirect	JJ
cord-288868-qfdxri93	132	30	manner	manner	NN
cord-288868-qfdxri93	132	31	,	,	,
cord-288868-qfdxri93	132	32	presumably	presumably	RB
cord-288868-qfdxri93	132	33	by	by	IN
cord-288868-qfdxri93	132	34	activating	activate	VBG
cord-288868-qfdxri93	132	35	another	another	DT
cord-288868-qfdxri93	132	36	subset	subset	NN
cord-288868-qfdxri93	132	37	of	of	IN
cord-288868-qfdxri93	132	38	T	t	NN
cord-288868-qfdxri93	132	39	cells	cell	NNS
cord-288868-qfdxri93	132	40	.	.	.
cord-288868-qfdxri93	133	1	It	-PRON-	PRP
cord-288868-qfdxri93	133	2	remains	remain	VBZ
cord-288868-qfdxri93	133	3	to	to	TO
cord-288868-qfdxri93	133	4	be	be	VB
cord-288868-qfdxri93	133	5	clarified	clarify	VBN
cord-288868-qfdxri93	133	6	,	,	,
cord-288868-qfdxri93	133	7	however	however	RB
cord-288868-qfdxri93	133	8	,	,	,
cord-288868-qfdxri93	133	9	how	how	WRB
cord-288868-qfdxri93	133	10	much	much	JJ
cord-288868-qfdxri93	133	11	of	of	IN
cord-288868-qfdxri93	133	12	this	this	DT
cord-288868-qfdxri93	133	13	reactivation	reactivation	NN
cord-288868-qfdxri93	133	14	is	be	VBZ
cord-288868-qfdxri93	133	15	due	due	JJ
cord-288868-qfdxri93	133	16	to	to	IN
cord-288868-qfdxri93	133	17	the	the	DT
cord-288868-qfdxri93	133	18	action	action	NN
cord-288868-qfdxri93	133	19	of	of	IN
cord-288868-qfdxri93	133	20	vaccine	vaccine	NN
cord-288868-qfdxri93	133	21	-	-	HYPH
cord-288868-qfdxri93	133	22	induced	induce	VBN
cord-288868-qfdxri93	133	23	T	t	NN
cord-288868-qfdxri93	133	24	cells	cell	NNS
cord-288868-qfdxri93	133	25	and	and	CC
cord-288868-qfdxri93	133	26	how	how	WRB
cord-288868-qfdxri93	133	27	much	much	JJ
cord-288868-qfdxri93	133	28	is	be	VBZ
cord-288868-qfdxri93	133	29	a	a	DT
cord-288868-qfdxri93	133	30	general	general	JJ
cord-288868-qfdxri93	133	31	,	,	,
cord-288868-qfdxri93	133	32	antigen	antigen	NN
cord-288868-qfdxri93	133	33	-	-	HYPH
cord-288868-qfdxri93	133	34	independent	independent	JJ
cord-288868-qfdxri93	133	35	immune	immune	NN
cord-288868-qfdxri93	133	36	-	-	HYPH
cord-288868-qfdxri93	133	37	enhancing	enhance	VBG
cord-288868-qfdxri93	133	38	effect	effect	NN
cord-288868-qfdxri93	133	39	.	.	.
cord-288868-qfdxri93	134	1	In	in	IN
cord-288868-qfdxri93	134	2	any	any	DT
cord-288868-qfdxri93	134	3	case	case	NN
cord-288868-qfdxri93	134	4	,	,	,
cord-288868-qfdxri93	134	5	for	for	IN
cord-288868-qfdxri93	134	6	the	the	DT
cord-288868-qfdxri93	134	7	development	development	NN
cord-288868-qfdxri93	134	8	of	of	IN
cord-288868-qfdxri93	134	9	therapeutic	therapeutic	JJ
cord-288868-qfdxri93	134	10	vaccines	vaccine	NNS
cord-288868-qfdxri93	134	11	,	,	,
cord-288868-qfdxri93	134	12	it	-PRON-	PRP
cord-288868-qfdxri93	134	13	will	will	MD
cord-288868-qfdxri93	134	14	be	be	VB
cord-288868-qfdxri93	134	15	vital	vital	JJ
cord-288868-qfdxri93	134	16	to	to	TO
cord-288868-qfdxri93	134	17	understand	understand	VB
cord-288868-qfdxri93	134	18	how	how	WRB
cord-288868-qfdxri93	134	19	the	the	DT
cord-288868-qfdxri93	134	20	balance	balance	NN
cord-288868-qfdxri93	134	21	can	can	MD
cord-288868-qfdxri93	134	22	be	be	VB
cord-288868-qfdxri93	134	23	tipped	tip	VBN
cord-288868-qfdxri93	134	24	back	back	RB
cord-288868-qfdxri93	134	25	from	from	IN
cord-288868-qfdxri93	134	26	a	a	DT
cord-288868-qfdxri93	134	27	state	state	NN
cord-288868-qfdxri93	134	28	of	of	IN
cord-288868-qfdxri93	134	29	tolerance	tolerance	NN
cord-288868-qfdxri93	134	30	to	to	IN
cord-288868-qfdxri93	134	31	a	a	DT
cord-288868-qfdxri93	134	32	successful	successful	JJ
cord-288868-qfdxri93	134	33	immune	immune	JJ
cord-288868-qfdxri93	134	34	response	response	NN
cord-288868-qfdxri93	134	35	.	.	.
cord-288868-qfdxri93	135	1	The	the	DT
cord-288868-qfdxri93	135	2	development	development	NN
cord-288868-qfdxri93	135	3	of	of	IN
cord-288868-qfdxri93	135	4	vaccines	vaccine	NNS
cord-288868-qfdxri93	135	5	aimed	aim	VBN
cord-288868-qfdxri93	135	6	at	at	IN
cord-288868-qfdxri93	135	7	the	the	DT
cord-288868-qfdxri93	135	8	polysaccharide	polysaccharide	NN
cord-288868-qfdxri93	135	9	(	(	-LRB-
cord-288868-qfdxri93	135	10	PS	PS	NNP
cord-288868-qfdxri93	135	11	)	)	-RRB-
cord-288868-qfdxri93	135	12	capsule	capsule	NN
cord-288868-qfdxri93	135	13	of	of	IN
cord-288868-qfdxri93	135	14	bacteria	bacteria	NNS
cord-288868-qfdxri93	135	15	is	be	VBZ
cord-288868-qfdxri93	135	16	one	one	CD
cord-288868-qfdxri93	135	17	of	of	IN
cord-288868-qfdxri93	135	18	the	the	DT
cord-288868-qfdxri93	135	19	great	great	JJ
cord-288868-qfdxri93	135	20	achievements	achievement	NNS
cord-288868-qfdxri93	135	21	in	in	IN
cord-288868-qfdxri93	135	22	vaccinology	vaccinology	NN
cord-288868-qfdxri93	135	23	.	.	.
cord-288868-qfdxri93	136	1	So	so	RB
cord-288868-qfdxri93	136	2	far	far	RB
cord-288868-qfdxri93	136	3	,	,	,
cord-288868-qfdxri93	136	4	the	the	DT
cord-288868-qfdxri93	136	5	PS	PS	NNP
cord-288868-qfdxri93	136	6	used	use	VBD
cord-288868-qfdxri93	136	7	in	in	IN
cord-288868-qfdxri93	136	8	largescale	largescale	JJ
cord-288868-qfdxri93	136	9	vaccine	vaccine	NN
cord-288868-qfdxri93	136	10	production	production	NN
cord-288868-qfdxri93	136	11	has	have	VBZ
cord-288868-qfdxri93	136	12	been	be	VBN
cord-288868-qfdxri93	136	13	purified	purify	VBN
cord-288868-qfdxri93	136	14	from	from	IN
cord-288868-qfdxri93	136	15	the	the	DT
cord-288868-qfdxri93	136	16	pathogen	pathogen	NN
cord-288868-qfdxri93	136	17	itself	-PRON-	PRP
cord-288868-qfdxri93	136	18	,	,	,
cord-288868-qfdxri93	136	19	grown	grow	VBN
cord-288868-qfdxri93	136	20	in	in	IN
cord-288868-qfdxri93	136	21	large	large	JJ
cord-288868-qfdxri93	136	22	quantities	quantity	NNS
cord-288868-qfdxri93	136	23	-an	-an	:
cord-288868-qfdxri93	136	24	approach	approach	NN
cord-288868-qfdxri93	136	25	that	that	WDT
cord-288868-qfdxri93	136	26	is	be	VBZ
cord-288868-qfdxri93	136	27	costly	costly	JJ
cord-288868-qfdxri93	136	28	and	and	CC
cord-288868-qfdxri93	136	29	difficult	difficult	JJ
cord-288868-qfdxri93	136	30	to	to	TO
cord-288868-qfdxri93	136	31	control	control	VB
cord-288868-qfdxri93	136	32	.	.	.
cord-288868-qfdxri93	137	1	Through	through	IN
cord-288868-qfdxri93	137	2	great	great	JJ
cord-288868-qfdxri93	137	3	simplification	simplification	NN
cord-288868-qfdxri93	137	4	of	of	IN
cord-288868-qfdxri93	137	5	the	the	DT
cord-288868-qfdxri93	137	6	carbohydrate	carbohydrate	NN
cord-288868-qfdxri93	137	7	chemistry	chemistry	NN
cord-288868-qfdxri93	137	8	involved	involve	VBN
cord-288868-qfdxri93	137	9	,	,	,
cord-288868-qfdxri93	137	10	Verez	Verez	NNP
cord-288868-qfdxri93	137	11	-	-	HYPH
cord-288868-qfdxri93	137	12	Bencomo	Bencomo	NNP
cord-288868-qfdxri93	137	13	et	et	NNP
cord-288868-qfdxri93	137	14	al	al	NNP
cord-288868-qfdxri93	137	15	.	.	.
cord-288868-qfdxri93	138	1	[	[	-LRB-
cord-288868-qfdxri93	138	2	57	57	CD
cord-288868-qfdxri93	138	3	]	]	-RRB-
cord-288868-qfdxri93	138	4	have	have	VBP
cord-288868-qfdxri93	138	5	now	now	RB
cord-288868-qfdxri93	138	6	demonstrated	demonstrate	VBN
cord-288868-qfdxri93	138	7	the	the	DT
cord-288868-qfdxri93	138	8	first	first	JJ
cord-288868-qfdxri93	138	9	large	large	JJ
cord-288868-qfdxri93	138	10	-	-	HYPH
cord-288868-qfdxri93	138	11	scale	scale	NN
cord-288868-qfdxri93	138	12	production	production	NN
cord-288868-qfdxri93	138	13	of	of	IN
cord-288868-qfdxri93	138	14	an	an	DT
cord-288868-qfdxri93	138	15	anti	anti	JJ
cord-288868-qfdxri93	138	16	-	-	JJ
cord-288868-qfdxri93	138	17	Haemophilus	haemophilus	JJ
cord-288868-qfdxri93	138	18	influenzae	influenzae	NN
cord-288868-qfdxri93	138	19	type	type	NN
cord-288868-qfdxri93	138	20	B	b	NN
cord-288868-qfdxri93	138	21	vaccine	vaccine	NN
cord-288868-qfdxri93	138	22	,	,	,
cord-288868-qfdxri93	138	23	consisting	consist	VBG
cord-288868-qfdxri93	138	24	of	of	IN
cord-288868-qfdxri93	138	25	synthetic	synthetic	JJ
cord-288868-qfdxri93	138	26	PS	PS	NNP
cord-288868-qfdxri93	138	27	conjugated	conjugate	VBN
cord-288868-qfdxri93	138	28	to	to	IN
cord-288868-qfdxri93	138	29	tetanus	tetanus	JJ
cord-288868-qfdxri93	138	30	toxoid	toxoid	NN
cord-288868-qfdxri93	138	31	protein	protein	NN
cord-288868-qfdxri93	138	32	carrier	carrier	NN
cord-288868-qfdxri93	138	33	.	.	.
cord-288868-qfdxri93	139	1	This	this	DT
cord-288868-qfdxri93	139	2	vaccine	vaccine	NN
cord-288868-qfdxri93	139	3	has	have	VBZ
cord-288868-qfdxri93	139	4	been	be	VBN
cord-288868-qfdxri93	139	5	shown	show	VBN
cord-288868-qfdxri93	139	6	to	to	TO
cord-288868-qfdxri93	139	7	be	be	VB
cord-288868-qfdxri93	139	8	as	as	RB
cord-288868-qfdxri93	139	9	efficient	efficient	JJ
cord-288868-qfdxri93	139	10	as	as	IN
cord-288868-qfdxri93	139	11	commercially	commercially	RB
cord-288868-qfdxri93	139	12	available	available	JJ
cord-288868-qfdxri93	139	13	vaccines	vaccine	NNS
cord-288868-qfdxri93	139	14	in	in	IN
cord-288868-qfdxri93	139	15	inducing	induce	VBG
cord-288868-qfdxri93	139	16	protective	protective	JJ
cord-288868-qfdxri93	139	17	levels	level	NNS
cord-288868-qfdxri93	139	18	of	of	IN
cord-288868-qfdxri93	139	19	antibody	antibody	NN
cord-288868-qfdxri93	139	20	titers	titer	NNS
cord-288868-qfdxri93	139	21	in	in	IN
cord-288868-qfdxri93	139	22	infants	infant	NNS
cord-288868-qfdxri93	139	23	.	.	.
cord-288868-qfdxri93	140	1	An	an	DT
cord-288868-qfdxri93	140	2	entirely	entirely	RB
cord-288868-qfdxri93	140	3	synthetic	synthetic	JJ
cord-288868-qfdxri93	140	4	vaccine	vaccine	NN
cord-288868-qfdxri93	140	5	with	with	IN
cord-288868-qfdxri93	140	6	a	a	DT
cord-288868-qfdxri93	140	7	branched	branched	JJ
cord-288868-qfdxri93	140	8	structure	structure	NN
cord-288868-qfdxri93	140	9	containing	contain	VBG
cord-288868-qfdxri93	140	10	a	a	DT
cord-288868-qfdxri93	140	11	TLR2	TLR2	NNP
cord-288868-qfdxri93	140	12	ligand	ligand	NN
cord-288868-qfdxri93	140	13	,	,	,
cord-288868-qfdxri93	140	14	a	a	DT
cord-288868-qfdxri93	140	15	CD4	CD4	NNP
cord-288868-qfdxri93	140	16	+	+	CC
cord-288868-qfdxri93	140	17	T	t	NN
cord-288868-qfdxri93	140	18	cell	cell	NN
cord-288868-qfdxri93	140	19	epitope	epitope	NN
cord-288868-qfdxri93	140	20	and	and	CC
cord-288868-qfdxri93	140	21	either	either	CC
cord-288868-qfdxri93	140	22	a	a	DT
cord-288868-qfdxri93	140	23	CD8	CD8	NNP
cord-288868-qfdxri93	140	24	+	+	CC
cord-288868-qfdxri93	140	25	T	T	NNP
cord-288868-qfdxri93	140	26	cell	cell	NN
cord-288868-qfdxri93	140	27	or	or	CC
cord-288868-qfdxri93	140	28	a	a	DT
cord-288868-qfdxri93	140	29	B	b	NN
cord-288868-qfdxri93	140	30	cell	cell	NN
cord-288868-qfdxri93	140	31	epitope	epitope	NN
cord-288868-qfdxri93	140	32	has	have	VBZ
cord-288868-qfdxri93	140	33	been	be	VBN
cord-288868-qfdxri93	140	34	shown	show	VBN
cord-288868-qfdxri93	140	35	to	to	TO
cord-288868-qfdxri93	140	36	elicit	elicit	VB
cord-288868-qfdxri93	140	37	strong	strong	JJ
cord-288868-qfdxri93	140	38	CD8	CD8	NNP
cord-288868-qfdxri93	140	39	+	+	CC
cord-288868-qfdxri93	140	40	T	T	NNP
cord-288868-qfdxri93	140	41	cell	cell	NN
cord-288868-qfdxri93	140	42	and	and	CC
cord-288868-qfdxri93	140	43	B	b	NN
cord-288868-qfdxri93	140	44	cell	cell	NN
cord-288868-qfdxri93	140	45	responses	response	NNS
cord-288868-qfdxri93	140	46	,	,	,
cord-288868-qfdxri93	140	47	respectively	respectively	RB
cord-288868-qfdxri93	140	48	[	[	-LRB-
cord-288868-qfdxri93	140	49	58	58	CD
cord-288868-qfdxri93	140	50	]	]	-RRB-
cord-288868-qfdxri93	140	51	.	.	.
cord-288868-qfdxri93	141	1	Here	here	RB
cord-288868-qfdxri93	141	2	,	,	,
cord-288868-qfdxri93	141	3	the	the	DT
cord-288868-qfdxri93	141	4	minimal	minimal	JJ
cord-288868-qfdxri93	141	5	requirements	requirement	NNS
cord-288868-qfdxri93	141	6	for	for	IN
cord-288868-qfdxri93	141	7	an	an	DT
cord-288868-qfdxri93	141	8	efficient	efficient	JJ
cord-288868-qfdxri93	141	9	vaccine	vaccine	NN
cord-288868-qfdxri93	141	10	are	be	VBP
cord-288868-qfdxri93	141	11	met	meet	VBN
cord-288868-qfdxri93	141	12	in	in	IN
cord-288868-qfdxri93	141	13	a	a	DT
cord-288868-qfdxri93	141	14	single	single	JJ
cord-288868-qfdxri93	141	15	molecule	molecule	NN
cord-288868-qfdxri93	141	16	:	:	:
cord-288868-qfdxri93	141	17	targeting	target	VBG
cord-288868-qfdxri93	141	18	to	to	IN
cord-288868-qfdxri93	141	19	and	and	CC
cord-288868-qfdxri93	141	20	activation	activation	NN
cord-288868-qfdxri93	141	21	of	of	IN
cord-288868-qfdxri93	141	22	DCs	DCs	NNP
cord-288868-qfdxri93	141	23	,	,	,
cord-288868-qfdxri93	141	24	T	T	NNP
cord-288868-qfdxri93	141	25	cell	cell	NN
cord-288868-qfdxri93	141	26	help	help	NN
cord-288868-qfdxri93	141	27	and	and	CC
cord-288868-qfdxri93	141	28	activation	activation	NN
cord-288868-qfdxri93	141	29	of	of	IN
cord-288868-qfdxri93	141	30	antigen	antigen	NN
cord-288868-qfdxri93	141	31	-	-	HYPH
cord-288868-qfdxri93	141	32	specific	specific	JJ
cord-288868-qfdxri93	141	33	CD8	CD8	NNP
cord-288868-qfdxri93	141	34	+	+	CC
cord-288868-qfdxri93	141	35	T	t	NN
cord-288868-qfdxri93	141	36	cells	cell	NNS
cord-288868-qfdxri93	141	37	or	or	CC
cord-288868-qfdxri93	141	38	B	b	NN
cord-288868-qfdxri93	141	39	cells	cell	NNS
cord-288868-qfdxri93	141	40	.	.	.
cord-288868-qfdxri93	142	1	The	the	DT
cord-288868-qfdxri93	142	2	world	world	NN
cord-288868-qfdxri93	142	3	of	of	IN
cord-288868-qfdxri93	142	4	vaccines	vaccine	NNS
cord-288868-qfdxri93	142	5	is	be	VBZ
cord-288868-qfdxri93	142	6	undergoing	undergo	VBG
cord-288868-qfdxri93	142	7	dramatic	dramatic	JJ
cord-288868-qfdxri93	142	8	changes	change	NNS
cord-288868-qfdxri93	142	9	.	.	.
cord-288868-qfdxri93	143	1	Never	never	RB
cord-288868-qfdxri93	143	2	before	before	IN
cord-288868-qfdxri93	143	3	have	have	VBP
cord-288868-qfdxri93	143	4	such	such	JJ
cord-288868-qfdxri93	143	5	sophisticated	sophisticated	JJ
cord-288868-qfdxri93	143	6	techniques	technique	NNS
cord-288868-qfdxri93	143	7	and	and	CC
cord-288868-qfdxri93	143	8	an	an	DT
cord-288868-qfdxri93	143	9	in	in	IN
cord-288868-qfdxri93	143	10	-	-	HYPH
cord-288868-qfdxri93	143	11	depth	depth	NN
cord-288868-qfdxri93	143	12	knowledge	knowledge	NN
cord-288868-qfdxri93	143	13	of	of	IN
cord-288868-qfdxri93	143	14	immunological	immunological	JJ
cord-288868-qfdxri93	143	15	processes	process	NNS
cord-288868-qfdxri93	143	16	been	be	VBN
cord-288868-qfdxri93	143	17	at	at	IN
cord-288868-qfdxri93	143	18	hand	hand	NN
cord-288868-qfdxri93	143	19	to	to	TO
cord-288868-qfdxri93	143	20	exploit	exploit	VB
cord-288868-qfdxri93	143	21	fully	fully	RB
cord-288868-qfdxri93	143	22	the	the	DT
cord-288868-qfdxri93	143	23	potential	potential	NN
cord-288868-qfdxri93	143	24	of	of	IN
cord-288868-qfdxri93	143	25	protecting	protect	VBG
cord-288868-qfdxri93	143	26	from	from	IN
cord-288868-qfdxri93	143	27	,	,	,
cord-288868-qfdxri93	143	28	as	as	RB
cord-288868-qfdxri93	143	29	well	well	RB
cord-288868-qfdxri93	143	30	as	as	IN
cord-288868-qfdxri93	143	31	curing	curing	NN
cord-288868-qfdxri93	143	32	,	,	,
cord-288868-qfdxri93	143	33	diseases	disease	NNS
cord-288868-qfdxri93	143	34	through	through	IN
cord-288868-qfdxri93	143	35	vaccination	vaccination	NN
cord-288868-qfdxri93	143	36	.	.	.
cord-288868-qfdxri93	144	1	A	a	DT
cord-288868-qfdxri93	144	2	formidable	formidable	JJ
cord-288868-qfdxri93	144	3	task	task	NN
cord-288868-qfdxri93	144	4	in	in	IN
cord-288868-qfdxri93	144	5	the	the	DT
cord-288868-qfdxri93	144	6	future	future	NN
cord-288868-qfdxri93	144	7	will	will	MD
cord-288868-qfdxri93	144	8	be	be	VB
cord-288868-qfdxri93	144	9	the	the	DT
cord-288868-qfdxri93	144	10	development	development	NN
cord-288868-qfdxri93	144	11	of	of	IN
cord-288868-qfdxri93	144	12	effective	effective	JJ
cord-288868-qfdxri93	144	13	therapeutic	therapeutic	JJ
cord-288868-qfdxri93	144	14	vaccines	vaccine	NNS
cord-288868-qfdxri93	144	15	,	,	,
cord-288868-qfdxri93	144	16	in	in	IN
cord-288868-qfdxri93	144	17	situations	situation	NNS
cord-288868-qfdxri93	144	18	where	where	WRB
cord-288868-qfdxri93	144	19	chronic	chronic	JJ
cord-288868-qfdxri93	144	20	antigen	antigen	NN
cord-288868-qfdxri93	144	21	exposure	exposure	NN
cord-288868-qfdxri93	144	22	by	by	IN
cord-288868-qfdxri93	144	23	itself	-PRON-	PRP
cord-288868-qfdxri93	144	24	does	do	VBZ
cord-288868-qfdxri93	144	25	not	not	RB
cord-288868-qfdxri93	144	26	elicit	elicit	VB
cord-288868-qfdxri93	144	27	a	a	DT
cord-288868-qfdxri93	144	28	sufficiently	sufficiently	RB
cord-288868-qfdxri93	144	29	strong	strong	JJ
cord-288868-qfdxri93	144	30	immune	immune	JJ
cord-288868-qfdxri93	144	31	response	response	NN
cord-288868-qfdxri93	144	32	,	,	,
cord-288868-qfdxri93	144	33	as	as	IN
cord-288868-qfdxri93	144	34	is	be	VBZ
cord-288868-qfdxri93	144	35	the	the	DT
cord-288868-qfdxri93	144	36	case	case	NN
cord-288868-qfdxri93	144	37	in	in	IN
cord-288868-qfdxri93	144	38	cancer	cancer	NN
cord-288868-qfdxri93	144	39	and	and	CC
cord-288868-qfdxri93	144	40	chronic	chronic	JJ
cord-288868-qfdxri93	144	41	infectious	infectious	JJ
cord-288868-qfdxri93	144	42	diseases	disease	NNS
cord-288868-qfdxri93	144	43	.	.	.
cord-288868-qfdxri93	145	1	Compared	compare	VBN
cord-288868-qfdxri93	145	2	with	with	IN
cord-288868-qfdxri93	145	3	vaccines	vaccine	NNS
cord-288868-qfdxri93	145	4	against	against	IN
cord-288868-qfdxri93	145	5	selflimiting	selflimite	VBG
cord-288868-qfdxri93	145	6	infections	infection	NNS
cord-288868-qfdxri93	145	7	,	,	,
cord-288868-qfdxri93	145	8	where	where	WRB
cord-288868-qfdxri93	145	9	the	the	DT
cord-288868-qfdxri93	145	10	aim	aim	NN
cord-288868-qfdxri93	145	11	is	be	VBZ
cord-288868-qfdxri93	145	12	to	to	TO
cord-288868-qfdxri93	145	13	be	be	VB
cord-288868-qfdxri93	145	14	as	as	RB
cord-288868-qfdxri93	145	15	good	good	JJ
cord-288868-qfdxri93	145	16	as	as	IN
cord-288868-qfdxri93	145	17	the	the	DT
cord-288868-qfdxri93	145	18	real	real	JJ
cord-288868-qfdxri93	145	19	pathogen	pathogen	NN
cord-288868-qfdxri93	145	20	(	(	-LRB-
cord-288868-qfdxri93	145	21	but	but	CC
cord-288868-qfdxri93	145	22	less	less	RBR
cord-288868-qfdxri93	145	23	harmful	harmful	JJ
cord-288868-qfdxri93	145	24	)	)	-RRB-
cord-288868-qfdxri93	145	25	,	,	,
cord-288868-qfdxri93	145	26	this	this	DT
cord-288868-qfdxri93	145	27	requires	require	VBZ
cord-288868-qfdxri93	145	28	the	the	DT
cord-288868-qfdxri93	145	29	development	development	NN
cord-288868-qfdxri93	145	30	of	of	IN
cord-288868-qfdxri93	145	31	vaccines	vaccine	NNS
cord-288868-qfdxri93	145	32	that	that	WDT
cord-288868-qfdxri93	145	33	are	be	VBP
cord-288868-qfdxri93	145	34	better	well	JJR
cord-288868-qfdxri93	145	35	than	than	IN
cord-288868-qfdxri93	145	36	the	the	DT
cord-288868-qfdxri93	145	37	natural	natural	JJ
cord-288868-qfdxri93	145	38	antigens	antigen	NNS
cord-288868-qfdxri93	145	39	in	in	IN
cord-288868-qfdxri93	145	40	inducing	induce	VBG
cord-288868-qfdxri93	145	41	immunity	immunity	NN
cord-288868-qfdxri93	145	42	.	.	.
cord-288868-qfdxri93	146	1	All	all	DT
cord-288868-qfdxri93	146	2	of	of	IN
cord-288868-qfdxri93	146	3	our	-PRON-	PRP$
cord-288868-qfdxri93	146	4	knowledge	knowledge	NN
cord-288868-qfdxri93	146	5	will	will	MD
cord-288868-qfdxri93	146	6	be	be	VB
cord-288868-qfdxri93	146	7	necessary	necessary	JJ
cord-288868-qfdxri93	146	8	to	to	TO
cord-288868-qfdxri93	146	9	succeed	succeed	VB
cord-288868-qfdxri93	146	10	in	in	IN
cord-288868-qfdxri93	146	11	this	this	DT
cord-288868-qfdxri93	146	12	challenge	challenge	NN
cord-288868-qfdxri93	146	13	.	.	.
cord-288868-qfdxri93	147	1	A	a	DT
cord-288868-qfdxri93	147	2	recent	recent	JJ
cord-288868-qfdxri93	147	3	article	article	NN
cord-288868-qfdxri93	147	4	describes	describe	VBZ
cord-288868-qfdxri93	147	5	the	the	DT
cord-288868-qfdxri93	147	6	use	use	NN
cord-288868-qfdxri93	147	7	of	of	IN
cord-288868-qfdxri93	147	8	multigenome	multigenome	NNP
cord-288868-qfdxri93	147	9	analysis	analysis	NN
cord-288868-qfdxri93	147	10	and	and	CC
cord-288868-qfdxri93	147	11	screening	screening	NN
cord-288868-qfdxri93	147	12	against	against	IN
cord-288868-qfdxri93	147	13	a	a	DT
cord-288868-qfdxri93	147	14	large	large	JJ
cord-288868-qfdxri93	147	15	panel	panel	NN
cord-288868-qfdxri93	147	16	of	of	IN
cord-288868-qfdxri93	147	17	strains	strain	NNS
cord-288868-qfdxri93	147	18	to	to	TO
cord-288868-qfdxri93	147	19	identify	identify	VB
cord-288868-qfdxri93	147	20	a	a	DT
cord-288868-qfdxri93	147	21	universal	universal	JJ
cord-288868-qfdxri93	147	22	group	group	NN
cord-288868-qfdxri93	147	23	B	B	NNP
cord-288868-qfdxri93	147	24	streptococcus	streptococcus	NN
cord-288868-qfdxri93	147	25	vaccine	vaccine	NN
cord-288868-qfdxri93	147	26	.	.	.
cord-288868-qfdxri93	148	1	Although	although	IN
cord-288868-qfdxri93	148	2	none	none	NN
cord-288868-qfdxri93	148	3	of	of	IN
cord-288868-qfdxri93	148	4	the	the	DT
cord-288868-qfdxri93	148	5	single	single	JJ
cord-288868-qfdxri93	148	6	antigens	antigen	NNS
cord-288868-qfdxri93	148	7	contained	contain	VBN
cord-288868-qfdxri93	148	8	in	in	IN
cord-288868-qfdxri93	148	9	the	the	DT
cord-288868-qfdxri93	148	10	vaccine	vaccine	NN
cord-288868-qfdxri93	148	11	elicits	elicit	VBZ
cord-288868-qfdxri93	148	12	protection	protection	NN
cord-288868-qfdxri93	148	13	against	against	IN
cord-288868-qfdxri93	148	14	all	all	DT
cord-288868-qfdxri93	148	15	strains	strain	NNS
cord-288868-qfdxri93	148	16	,	,	,
cord-288868-qfdxri93	148	17	the	the	DT
cord-288868-qfdxri93	148	18	combination	combination	NN
cord-288868-qfdxri93	148	19	of	of	IN
cord-288868-qfdxri93	148	20	four	four	CD
cord-288868-qfdxri93	148	21	proteins	protein	NNS
cord-288868-qfdxri93	148	22	is	be	VBZ
cord-288868-qfdxri93	148	23	able	able	JJ
cord-288868-qfdxri93	148	24	to	to	TO
cord-288868-qfdxri93	148	25	cover	cover	VB
cord-288868-qfdxri93	148	26	a	a	DT
cord-288868-qfdxri93	148	27	wide	wide	JJ
cord-288868-qfdxri93	148	28	range	range	NN
cord-288868-qfdxri93	148	29	of	of	IN
cord-288868-qfdxri93	148	30	strains	strain	NNS
cord-288868-qfdxri93	148	31	[	[	-LRB-
cord-288868-qfdxri93	148	32	60	60	CD
cord-288868-qfdxri93	148	33	]	]	-RRB-
cord-288868-qfdxri93	148	34	.	.	.
cord-288868-qfdxri93	148	35	 	 	_SP
cord-288868-qfdxri93	149	1	Mueller	Mueller	NNP
cord-288868-qfdxri93	149	2	AK	AK	NNP
cord-288868-qfdxri93	149	3	,	,	,
cord-288868-qfdxri93	149	4	Labaied	Labaied	NNP
cord-288868-qfdxri93	149	5	M	M	NNP
cord-288868-qfdxri93	149	6	,	,	,
cord-288868-qfdxri93	149	7	Kappe	Kappe	NNP
cord-288868-qfdxri93	149	8	SH	SH	NNP
cord-288868-qfdxri93	149	9	,	,	,
cord-288868-qfdxri93	149	10	Matuschewski	Matuschewski	NNP
cord-288868-qfdxri93	149	11	K	K	NNP
cord-288868-qfdxri93	149	12	:	:	:
cord-288868-qfdxri93	150	1	Genetically	genetically	RB
cord-288868-qfdxri93	150	2	modified	modify	VBN
cord-288868-qfdxri93	150	3	Plasmodium	Plasmodium	NNP
cord-288868-qfdxri93	150	4	parasites	parasite	NNS
cord-288868-qfdxri93	150	5	as	as	IN
cord-288868-qfdxri93	150	6	a	a	DT
cord-288868-qfdxri93	150	7	protective	protective	JJ
cord-288868-qfdxri93	150	8	experimental	experimental	JJ
cord-288868-qfdxri93	150	9	malaria	malaria	NN
cord-288868-qfdxri93	150	10	vaccine	vaccine	NN
cord-288868-qfdxri93	150	11	.	.	.
cord-288868-qfdxri93	151	1	Nature	nature	NN
cord-288868-qfdxri93	151	2	2005	2005	CD
cord-288868-qfdxri93	151	3	,	,	,
cord-288868-qfdxri93	151	4	433:164	433:164	CD
cord-288868-qfdxri93	151	5	-	-	SYM
cord-288868-qfdxri93	151	6	167	167	CD
cord-288868-qfdxri93	151	7	.	.	.
cord-288868-qfdxri93	152	1	In	in	IN
cord-288868-qfdxri93	152	2	this	this	DT
cord-288868-qfdxri93	152	3	study	study	NN
cord-288868-qfdxri93	152	4	,	,	,
cord-288868-qfdxri93	152	5	reverse	reverse	JJ
cord-288868-qfdxri93	152	6	genetics	genetic	NNS
cord-288868-qfdxri93	152	7	was	be	VBD
cord-288868-qfdxri93	152	8	used	use	VBN
cord-288868-qfdxri93	152	9	to	to	TO
cord-288868-qfdxri93	152	10	generate	generate	VB
cord-288868-qfdxri93	152	11	a	a	DT
cord-288868-qfdxri93	152	12	Plasmodium	Plasmodium	NNP
cord-288868-qfdxri93	152	13	knockout	knockout	NN
cord-288868-qfdxri93	152	14	strain	strain	NN
cord-288868-qfdxri93	152	15	with	with	IN
cord-288868-qfdxri93	152	16	a	a	DT
cord-288868-qfdxri93	152	17	developmental	developmental	JJ
cord-288868-qfdxri93	152	18	block	block	NN
cord-288868-qfdxri93	152	19	at	at	IN
cord-288868-qfdxri93	152	20	the	the	DT
cord-288868-qfdxri93	152	21	early	early	JJ
cord-288868-qfdxri93	152	22	liver	liver	NN
cord-288868-qfdxri93	152	23	stage	stage	NN
cord-288868-qfdxri93	152	24	.	.	.
cord-288868-qfdxri93	153	1	If	if	IN
cord-288868-qfdxri93	153	2	used	use	VBN
cord-288868-qfdxri93	153	3	as	as	IN
cord-288868-qfdxri93	153	4	a	a	DT
cord-288868-qfdxri93	153	5	live	live	JJ
cord-288868-qfdxri93	153	6	attenuated	attenuated	JJ
cord-288868-qfdxri93	153	7	vaccine	vaccine	NN
cord-288868-qfdxri93	153	8	in	in	IN
cord-288868-qfdxri93	153	9	a	a	DT
cord-288868-qfdxri93	153	10	malaria	malaria	NN
cord-288868-qfdxri93	153	11	mouse	mouse	NN
cord-288868-qfdxri93	153	12	model	model	NN
cord-288868-qfdxri93	153	13	,	,	,
cord-288868-qfdxri93	153	14	this	this	DT
cord-288868-qfdxri93	153	15	strain	strain	NN
cord-288868-qfdxri93	153	16	confers	confer	VBZ
cord-288868-qfdxri93	153	17	protection	protection	NN
cord-288868-qfdxri93	153	18	against	against	IN
cord-288868-qfdxri93	153	19	infectious	infectious	JJ
cord-288868-qfdxri93	153	20	sporozoite	sporozoite	NNP
cord-288868-qfdxri93	153	21	challenge	challenge	NN
cord-288868-qfdxri93	153	22	.	.	.
cord-288868-qfdxri93	154	1	Origin	Origin	NNP
cord-288868-qfdxri93	154	2	of	of	IN
cord-288868-qfdxri93	154	3	HIV-1	HIV-1	NNP
cord-288868-qfdxri93	154	4	in	in	IN
cord-288868-qfdxri93	154	5	the	the	DT
cord-288868-qfdxri93	154	6	chimpanzee	chimpanzee	NN
cord-288868-qfdxri93	154	7	Pan	Pan	NNP
cord-288868-qfdxri93	154	8	troglodytes	troglodyte	NNS
cord-288868-qfdxri93	154	9	troglodytes	troglodyte	NNS
cord-288868-qfdxri93	154	10	Multiple	Multiple	NNP
cord-288868-qfdxri93	154	11	Ebola	Ebola	NNP
cord-288868-qfdxri93	154	12	virus	virus	NN
cord-288868-qfdxri93	154	13	transmission	transmission	NN
cord-288868-qfdxri93	154	14	events	event	NNS
cord-288868-qfdxri93	154	15	and	and	CC
cord-288868-qfdxri93	154	16	rapid	rapid	JJ
cord-288868-qfdxri93	154	17	decline	decline	NN
cord-288868-qfdxri93	154	18	of	of	IN
cord-288868-qfdxri93	154	19	central	central	JJ
cord-288868-qfdxri93	154	20	African	african	JJ
cord-288868-qfdxri93	154	21	wildlife	wildlife	NN
cord-288868-qfdxri93	154	22	Human	Human	NNP
cord-288868-qfdxri93	154	23	Ebola	Ebola	NNP
cord-288868-qfdxri93	154	24	virus	virus	NN
cord-288868-qfdxri93	154	25	outbreaks	outbreak	NNS
cord-288868-qfdxri93	154	26	consist	consist	VBP
cord-288868-qfdxri93	154	27	of	of	IN
cord-288868-qfdxri93	154	28	parallel	parallel	JJ
cord-288868-qfdxri93	154	29	epidemics	epidemic	NNS
cord-288868-qfdxri93	154	30	caused	cause	VBN
cord-288868-qfdxri93	154	31	by	by	IN
cord-288868-qfdxri93	154	32	several	several	JJ
cord-288868-qfdxri93	154	33	different	different	JJ
cord-288868-qfdxri93	154	34	viral	viral	JJ
cord-288868-qfdxri93	154	35	strains	strain	NNS
cord-288868-qfdxri93	154	36	which	which	WDT
cord-288868-qfdxri93	154	37	appear	appear	VBP
cord-288868-qfdxri93	154	38	to	to	TO
cord-288868-qfdxri93	154	39	be	be	VB
cord-288868-qfdxri93	154	40	transmitted	transmit	VBN
cord-288868-qfdxri93	154	41	to	to	IN
cord-288868-qfdxri93	154	42	humans	human	NNS
cord-288868-qfdxri93	154	43	through	through	IN
cord-288868-qfdxri93	154	44	handling	handling	NN
cord-288868-qfdxri93	154	45	of	of	IN
cord-288868-qfdxri93	154	46	gorilla	gorilla	NN
cord-288868-qfdxri93	154	47	,	,	,
cord-288868-qfdxri93	154	48	chimpanzee	chimpanzee	NN
cord-288868-qfdxri93	154	49	or	or	CC
cord-288868-qfdxri93	154	50	duiker	duiker	NN
cord-288868-qfdxri93	154	51	carcasses	carcass	NNS
cord-288868-qfdxri93	155	1	Molecular	molecular	JJ
cord-288868-qfdxri93	155	2	evolution	evolution	NN
cord-288868-qfdxri93	155	3	of	of	IN
cord-288868-qfdxri93	155	4	the	the	DT
cord-288868-qfdxri93	155	5	SARS	SARS	NNP
cord-288868-qfdxri93	155	6	coronavirus	coronavirus	NN
cord-288868-qfdxri93	155	7	during	during	IN
cord-288868-qfdxri93	155	8	the	the	DT
cord-288868-qfdxri93	155	9	course	course	NN
cord-288868-qfdxri93	155	10	of	of	IN
cord-288868-qfdxri93	155	11	the	the	DT
cord-288868-qfdxri93	155	12	SARS	SARS	NNP
cord-288868-qfdxri93	155	13	epidemic	epidemic	NN
cord-288868-qfdxri93	155	14	in	in	IN
cord-288868-qfdxri93	155	15	China	China	NNP
cord-288868-qfdxri93	156	1	The	the	DT
cord-288868-qfdxri93	156	2	Chinese	chinese	JJ
cord-288868-qfdxri93	156	3	SARS	SARS	NNP
cord-288868-qfdxri93	156	4	consortium	consortium	NN
cord-288868-qfdxri93	156	5	demonstrates	demonstrate	VBZ
cord-288868-qfdxri93	156	6	that	that	IN
cord-288868-qfdxri93	156	7	virus	virus	NN
cord-288868-qfdxri93	156	8	sequences	sequence	NNS
cord-288868-qfdxri93	156	9	from	from	IN
cord-288868-qfdxri93	156	10	the	the	DT
cord-288868-qfdxri93	156	11	earliest	early	JJS
cord-288868-qfdxri93	156	12	patients	patient	NNS
cord-288868-qfdxri93	156	13	are	be	VBP
cord-288868-qfdxri93	156	14	identical	identical	JJ
cord-288868-qfdxri93	156	15	to	to	IN
cord-288868-qfdxri93	156	16	those	those	DT
cord-288868-qfdxri93	156	17	found	find	VBN
cord-288868-qfdxri93	156	18	in	in	IN
cord-288868-qfdxri93	156	19	palm	palm	NN
cord-288868-qfdxri93	156	20	civets	civet	NNS
cord-288868-qfdxri93	156	21	,	,	,
cord-288868-qfdxri93	156	22	and	and	CC
cord-288868-qfdxri93	156	23	seven	seven	CD
cord-288868-qfdxri93	156	24	out	out	IN
cord-288868-qfdxri93	156	25	of	of	IN
cord-288868-qfdxri93	156	26	11	11	CD
cord-288868-qfdxri93	156	27	cases	case	NNS
cord-288868-qfdxri93	156	28	had	have	VBD
cord-288868-qfdxri93	156	29	documented	document	VBN
cord-288868-qfdxri93	156	30	contact	contact	NN
cord-288868-qfdxri93	156	31	with	with	IN
cord-288868-qfdxri93	156	32	wild	wild	JJ
cord-288868-qfdxri93	156	33	animals	animal	NNS
cord-288868-qfdxri93	156	34	.	.	.
cord-288868-qfdxri93	157	1	In	in	IN
cord-288868-qfdxri93	157	2	addition	addition	NN
cord-288868-qfdxri93	157	3	,	,	,
cord-288868-qfdxri93	157	4	the	the	DT
cord-288868-qfdxri93	157	5	isolated	isolate	VBN
cord-288868-qfdxri93	157	6	case	case	NN
cord-288868-qfdxri93	157	7	in	in	IN
cord-288868-qfdxri93	157	8	December	December	NNP
cord-288868-qfdxri93	157	9	2003	2003	CD
cord-288868-qfdxri93	157	10	was	be	VBD
cord-288868-qfdxri93	157	11	caused	cause	VBN
cord-288868-qfdxri93	157	12	by	by	IN
cord-288868-qfdxri93	157	13	a	a	DT
cord-288868-qfdxri93	157	14	virus	virus	NN
cord-288868-qfdxri93	157	15	with	with	IN
cord-288868-qfdxri93	157	16	highest	high	JJS
cord-288868-qfdxri93	157	17	sequence	sequence	NN
cord-288868-qfdxri93	157	18	homology	homology	NN
cord-288868-qfdxri93	157	19	to	to	IN
cord-288868-qfdxri93	157	20	palm	palm	NN
cord-288868-qfdxri93	157	21	civets	civet	NNS
cord-288868-qfdxri93	157	22	West	West	NNP
cord-288868-qfdxri93	157	23	Nile	Nile	NNP
cord-288868-qfdxri93	157	24	virus	virus	NN
cord-288868-qfdxri93	157	25	:	:	:
cord-288868-qfdxri93	157	26	where	where	WRB
cord-288868-qfdxri93	157	27	are	be	VBP
cord-288868-qfdxri93	157	28	we	-PRON-	PRP
cord-288868-qfdxri93	157	29	now	now	RB
cord-288868-qfdxri93	157	30	?	?	.
cord-288868-qfdxri93	158	1	From	from	IN
cord-288868-qfdxri93	158	2	Pasteur	Pasteur	NNP
cord-288868-qfdxri93	158	3	to	to	IN
cord-288868-qfdxri93	158	4	genomics	genomic	NNS
cord-288868-qfdxri93	158	5	:	:	:
cord-288868-qfdxri93	158	6	progress	progress	NN
cord-288868-qfdxri93	158	7	and	and	CC
cord-288868-qfdxri93	158	8	challenges	challenge	NNS
cord-288868-qfdxri93	158	9	in	in	IN
cord-288868-qfdxri93	158	10	infectious	infectious	JJ
cord-288868-qfdxri93	158	11	diseases	disease	NNS
cord-288868-qfdxri93	159	1	Pandemic	pandemic	NN
cord-288868-qfdxri93	159	2	influenza	influenza	NN
cord-288868-qfdxri93	159	3	:	:	:
cord-288868-qfdxri93	159	4	a	a	DT
cord-288868-qfdxri93	159	5	zoonosis	zoonosis	NN
cord-288868-qfdxri93	159	6	?	?	.
cord-288868-qfdxri93	160	1	Semin	Semin	NNP
cord-288868-qfdxri93	161	1	Respir	Respir	NNP
cord-288868-qfdxri93	161	2	Infect	infect	VB
cord-288868-qfdxri93	161	3	Serological	serological	JJ
cord-288868-qfdxri93	161	4	evidence	evidence	NN
cord-288868-qfdxri93	161	5	of	of	IN
cord-288868-qfdxri93	161	6	human	human	JJ
cord-288868-qfdxri93	161	7	infections	infection	NNS
cord-288868-qfdxri93	161	8	with	with	IN
cord-288868-qfdxri93	161	9	avian	avian	JJ
cord-288868-qfdxri93	161	10	influenza	influenza	NN
cord-288868-qfdxri93	161	11	viruses	virus	NNS
cord-288868-qfdxri93	162	1	Influenza	influenza	NN
cord-288868-qfdxri93	162	2	:	:	:
cord-288868-qfdxri93	162	3	old	old	JJ
cord-288868-qfdxri93	162	4	and	and	CC
cord-288868-qfdxri93	162	5	new	new	JJ
cord-288868-qfdxri93	162	6	threats	threat	NNS
cord-288868-qfdxri93	162	7	SARS	SARS	NNP
cord-288868-qfdxri93	162	8	-beginning	-beginne	VBG
cord-288868-qfdxri93	163	1	to	to	TO
cord-288868-qfdxri93	163	2	understand	understand	VB
cord-288868-qfdxri93	163	3	a	a	DT
cord-288868-qfdxri93	163	4	new	new	JJ
cord-288868-qfdxri93	163	5	virus	virus	NN
cord-288868-qfdxri93	164	1	A	a	DT
cord-288868-qfdxri93	164	2	DNA	dna	NN
cord-288868-qfdxri93	164	3	vaccine	vaccine	NN
cord-288868-qfdxri93	164	4	induces	induce	VBZ
cord-288868-qfdxri93	164	5	SARS	SARS	NNP
cord-288868-qfdxri93	164	6	coronavirus	coronavirus	NN
cord-288868-qfdxri93	164	7	neutralization	neutralization	NN
cord-288868-qfdxri93	164	8	and	and	CC
cord-288868-qfdxri93	164	9	protective	protective	JJ
cord-288868-qfdxri93	164	10	immunity	immunity	NN
cord-288868-qfdxri93	164	11	in	in	IN
cord-288868-qfdxri93	164	12	mice	mice	NN
cord-288868-qfdxri93	164	13	Severe	severe	JJ
cord-288868-qfdxri93	164	14	acute	acute	JJ
cord-288868-qfdxri93	164	15	respiratory	respiratory	JJ
cord-288868-qfdxri93	164	16	syndrome	syndrome	NN
cord-288868-qfdxri93	164	17	coronavirus	coronavirus	NN
cord-288868-qfdxri93	164	18	spike	spike	NN
cord-288868-qfdxri93	164	19	protein	protein	NN
cord-288868-qfdxri93	164	20	expressed	express	VBN
cord-288868-qfdxri93	164	21	by	by	IN
cord-288868-qfdxri93	164	22	attenuated	attenuated	JJ
cord-288868-qfdxri93	164	23	vaccinia	vaccinia	NN
cord-288868-qfdxri93	164	24	virus	virus	NN
cord-288868-qfdxri93	164	25	protectively	protectively	RB
cord-288868-qfdxri93	164	26	immunizes	immunize	VBZ
cord-288868-qfdxri93	164	27	mice	mouse	NNS
cord-288868-qfdxri93	165	1	An	an	DT
cord-288868-qfdxri93	165	2	efficient	efficient	JJ
cord-288868-qfdxri93	165	3	method	method	NN
cord-288868-qfdxri93	165	4	to	to	TO
cord-288868-qfdxri93	165	5	make	make	VB
cord-288868-qfdxri93	165	6	human	human	JJ
cord-288868-qfdxri93	165	7	monoclonal	monoclonal	JJ
cord-288868-qfdxri93	165	8	antibodies	antibody	NNS
cord-288868-qfdxri93	165	9	from	from	IN
cord-288868-qfdxri93	165	10	memory	memory	NN
cord-288868-qfdxri93	165	11	B	b	NN
cord-288868-qfdxri93	165	12	cells	cell	NNS
cord-288868-qfdxri93	165	13	:	:	:
cord-288868-qfdxri93	165	14	potent	potent	JJ
cord-288868-qfdxri93	165	15	neutralization	neutralization	NN
cord-288868-qfdxri93	165	16	of	of	IN
cord-288868-qfdxri93	165	17	SARS	SARS	NNP
cord-288868-qfdxri93	165	18	coronavirus	coronavirus	NN
cord-288868-qfdxri93	165	19	Rescue	Rescue	NNP
cord-288868-qfdxri93	165	20	of	of	IN
cord-288868-qfdxri93	165	21	influenza	influenza	NN
cord-288868-qfdxri93	165	22	A	a	DT
cord-288868-qfdxri93	165	23	virus	virus	NN
cord-288868-qfdxri93	165	24	from	from	IN
cord-288868-qfdxri93	165	25	recombinant	recombinant	JJ
cord-288868-qfdxri93	165	26	DNA	DNA	NNP
cord-288868-qfdxri93	165	27	Generation	Generation	NNP
cord-288868-qfdxri93	165	28	of	of	IN
cord-288868-qfdxri93	165	29	influenza	influenza	NN
cord-288868-qfdxri93	165	30	A	a	DT
cord-288868-qfdxri93	165	31	viruses	virus	NNS
cord-288868-qfdxri93	165	32	entirely	entirely	RB
cord-288868-qfdxri93	165	33	from	from	IN
cord-288868-qfdxri93	165	34	cloned	clone	VBN
cord-288868-qfdxri93	165	35	cDNAs	cDNAs	:
cord-288868-qfdxri93	165	36	Responsiveness	Responsiveness	NNP
cord-288868-qfdxri93	165	37	to	to	IN
cord-288868-qfdxri93	165	38	a	a	DT
cord-288868-qfdxri93	165	39	pandemic	pandemic	JJ
cord-288868-qfdxri93	165	40	alert	alert	NN
cord-288868-qfdxri93	165	41	:	:	:
cord-288868-qfdxri93	165	42	use	use	NN
cord-288868-qfdxri93	165	43	of	of	IN
cord-288868-qfdxri93	165	44	reverse	reverse	JJ
cord-288868-qfdxri93	165	45	genetics	genetic	NNS
cord-288868-qfdxri93	165	46	for	for	IN
cord-288868-qfdxri93	165	47	rapid	rapid	JJ
cord-288868-qfdxri93	165	48	development	development	NN
cord-288868-qfdxri93	165	49	of	of	IN
cord-288868-qfdxri93	165	50	influenza	influenza	NN
cord-288868-qfdxri93	165	51	vaccines	vaccine	NNS
cord-288868-qfdxri93	166	1	This	this	DT
cord-288868-qfdxri93	166	2	paper	paper	NN
cord-288868-qfdxri93	166	3	demonstrates	demonstrate	VBZ
cord-288868-qfdxri93	166	4	the	the	DT
cord-288868-qfdxri93	166	5	rapid	rapid	JJ
cord-288868-qfdxri93	166	6	generation	generation	NN
cord-288868-qfdxri93	166	7	of	of	IN
cord-288868-qfdxri93	166	8	a	a	DT
cord-288868-qfdxri93	166	9	genetically	genetically	RB
cord-288868-qfdxri93	166	10	attenuated	attenuate	VBN
cord-288868-qfdxri93	166	11	influenza	influenza	NN
cord-288868-qfdxri93	166	12	H5N1	H5N1	NNP
cord-288868-qfdxri93	166	13	reference	reference	NN
cord-288868-qfdxri93	166	14	vaccine	vaccine	NN
cord-288868-qfdxri93	166	15	strain	strain	NN
cord-288868-qfdxri93	166	16	by	by	IN
cord-288868-qfdxri93	166	17	use	use	NN
cord-288868-qfdxri93	166	18	of	of	IN
cord-288868-qfdxri93	166	19	reverse	reverse	JJ
cord-288868-qfdxri93	166	20	genetics	genetics	NN
cord-288868-qfdxri93	166	21	Evaluation	Evaluation	NNP
cord-288868-qfdxri93	166	22	of	of	IN
cord-288868-qfdxri93	166	23	a	a	DT
cord-288868-qfdxri93	166	24	genetically	genetically	RB
cord-288868-qfdxri93	166	25	modified	modify	VBN
cord-288868-qfdxri93	166	26	reassortant	reassortant	NN
cord-288868-qfdxri93	166	27	H5N1	H5N1	NNP
cord-288868-qfdxri93	167	1	influenza	influenza	NN
cord-288868-qfdxri93	167	2	A	a	DT
cord-288868-qfdxri93	167	3	virus	virus	NN
cord-288868-qfdxri93	167	4	vaccine	vaccine	NN
cord-288868-qfdxri93	167	5	candidate	candidate	NN
cord-288868-qfdxri93	167	6	generated	generate	VBN
cord-288868-qfdxri93	167	7	by	by	IN
cord-288868-qfdxri93	167	8	plasmid	plasmid	NN
cord-288868-qfdxri93	167	9	-	-	HYPH
cord-288868-qfdxri93	167	10	based	base	VBN
cord-288868-qfdxri93	167	11	reverse	reverse	NN
cord-288868-qfdxri93	167	12	genetics	genetics	NN
cord-288868-qfdxri93	167	13	Serum	serum	NN
cord-288868-qfdxri93	167	14	antibody	antibody	NN
cord-288868-qfdxri93	167	15	responses	response	NNS
cord-288868-qfdxri93	167	16	after	after	IN
cord-288868-qfdxri93	167	17	intradermal	intradermal	JJ
cord-288868-qfdxri93	167	18	vaccination	vaccination	NN
cord-288868-qfdxri93	167	19	against	against	IN
cord-288868-qfdxri93	167	20	influenza	influenza	NN
cord-288868-qfdxri93	167	21	See	see	VB
cord-288868-qfdxri93	167	22	annotation	annotation	NN
cord-288868-qfdxri93	167	23	to	to	IN
cord-288868-qfdxri93	167	24	Efficacy	Efficacy	NNP
cord-288868-qfdxri93	167	25	of	of	IN
cord-288868-qfdxri93	167	26	the	the	DT
cord-288868-qfdxri93	167	27	RTS	RTS	NNP
cord-288868-qfdxri93	167	28	,	,	,
cord-288868-qfdxri93	167	29	S	S	NNP
cord-288868-qfdxri93	167	30	/	/	SYM
cord-288868-qfdxri93	167	31	AS02A	as02a	JJ
cord-288868-qfdxri93	167	32	vaccine	vaccine	NN
cord-288868-qfdxri93	167	33	against	against	IN
cord-288868-qfdxri93	167	34	Plasmodium	Plasmodium	NNP
cord-288868-qfdxri93	167	35	falciparum	falciparum	NN
cord-288868-qfdxri93	167	36	infection	infection	NN
cord-288868-qfdxri93	167	37	and	and	CC
cord-288868-qfdxri93	167	38	disease	disease	NN
cord-288868-qfdxri93	167	39	in	in	IN
cord-288868-qfdxri93	167	40	young	young	JJ
cord-288868-qfdxri93	167	41	African	african	JJ
cord-288868-qfdxri93	167	42	children	child	NNS
cord-288868-qfdxri93	167	43	:	:	:
cord-288868-qfdxri93	167	44	randomised	randomised	JJ
cord-288868-qfdxri93	167	45	controlled	control	VBN
cord-288868-qfdxri93	167	46	trial	trial	NN
cord-288868-qfdxri93	167	47	This	this	DT
cord-288868-qfdxri93	167	48	vaccine	vaccine	NN
cord-288868-qfdxri93	167	49	contains	contain	VBZ
cord-288868-qfdxri93	167	50	a	a	DT
cord-288868-qfdxri93	167	51	yeast	yeast	NN
cord-288868-qfdxri93	167	52	-	-	HYPH
cord-288868-qfdxri93	167	53	expressed	express	VBN
cord-288868-qfdxri93	167	54	hybrid	hybrid	JJ
cord-288868-qfdxri93	167	55	molecule	molecule	NN
cord-288868-qfdxri93	167	56	composed	compose	VBN
cord-288868-qfdxri93	167	57	of	of	IN
cord-288868-qfdxri93	167	58	a	a	DT
cord-288868-qfdxri93	167	59	part	part	NN
cord-288868-qfdxri93	167	60	of	of	IN
cord-288868-qfdxri93	167	61	the	the	DT
cord-288868-qfdxri93	167	62	circumsporozoite	circumsporozoite	JJ
cord-288868-qfdxri93	167	63	protein	protein	NN
cord-288868-qfdxri93	167	64	and	and	CC
cord-288868-qfdxri93	167	65	the	the	DT
cord-288868-qfdxri93	167	66	HBV	HBV	NNP
cord-288868-qfdxri93	167	67	surface	surface	NN
cord-288868-qfdxri93	167	68	antigen	antigen	NN
cord-288868-qfdxri93	167	69	,	,	,
cord-288868-qfdxri93	167	70	formulated	formulate	VBN
cord-288868-qfdxri93	167	71	in	in	IN
cord-288868-qfdxri93	167	72	a	a	DT
cord-288868-qfdxri93	167	73	complex	complex	JJ
cord-288868-qfdxri93	167	74	adjuvant	adjuvant	NN
cord-288868-qfdxri93	167	75	.	.	.
cord-288868-qfdxri93	168	1	Significant	significant	JJ
cord-288868-qfdxri93	168	2	efficacy	efficacy	NN
cord-288868-qfdxri93	168	3	,	,	,
cord-288868-qfdxri93	168	4	in	in	IN
cord-288868-qfdxri93	168	5	terms	term	NNS
cord-288868-qfdxri93	168	6	of	of	IN
cord-288868-qfdxri93	168	7	prevention	prevention	NN
cord-288868-qfdxri93	168	8	of	of	IN
cord-288868-qfdxri93	168	9	clinical	clinical	JJ
cord-288868-qfdxri93	168	10	episodes	episode	NNS
cord-288868-qfdxri93	168	11	and	and	CC
cord-288868-qfdxri93	168	12	of	of	IN
cord-288868-qfdxri93	168	13	severe	severe	JJ
cord-288868-qfdxri93	168	14	malaria	malaria	NN
cord-288868-qfdxri93	168	15	A	a	DT
cord-288868-qfdxri93	168	16	CD4(+	CD4(+	NNP
cord-288868-qfdxri93	168	17	)	)	-RRB-
cord-288868-qfdxri93	168	18	T	t	NN
cord-288868-qfdxri93	168	19	-	-	HYPH
cord-288868-qfdxri93	168	20	cell	cell	NN
cord-288868-qfdxri93	168	21	immune	immune	JJ
cord-288868-qfdxri93	168	22	response	response	NN
cord-288868-qfdxri93	168	23	to	to	IN
cord-288868-qfdxri93	168	24	a	a	DT
cord-288868-qfdxri93	168	25	conserved	conserved	JJ
cord-288868-qfdxri93	168	26	epitope	epitope	NN
cord-288868-qfdxri93	168	27	in	in	IN
cord-288868-qfdxri93	168	28	the	the	DT
cord-288868-qfdxri93	168	29	circumsporozoite	circumsporozoite	JJ
cord-288868-qfdxri93	168	30	protein	protein	NN
cord-288868-qfdxri93	168	31	correlates	correlate	VBZ
cord-288868-qfdxri93	168	32	with	with	IN
cord-288868-qfdxri93	168	33	protection	protection	NN
cord-288868-qfdxri93	168	34	from	from	IN
cord-288868-qfdxri93	168	35	natural	natural	JJ
cord-288868-qfdxri93	168	36	Plasmodium	Plasmodium	NNP
cord-288868-qfdxri93	168	37	falciparum	falciparum	NN
cord-288868-qfdxri93	168	38	infection	infection	NN
cord-288868-qfdxri93	168	39	and	and	CC
cord-288868-qfdxri93	168	40	disease	disease	NN
cord-288868-qfdxri93	168	41	Using	use	VBG
cord-288868-qfdxri93	168	42	an	an	DT
cord-288868-qfdxri93	168	43	enzyme	enzyme	NN
cord-288868-qfdxri93	168	44	-	-	HYPH
cord-288868-qfdxri93	168	45	linked	link	VBN
cord-288868-qfdxri93	168	46	immunospot	immunospot	NN
cord-288868-qfdxri93	168	47	assay	assay	NN
cord-288868-qfdxri93	168	48	on	on	IN
cord-288868-qfdxri93	168	49	T	T	NNP
cord-288868-qfdxri93	168	50	cells	cell	NNS
cord-288868-qfdxri93	168	51	previously	previously	RB
cord-288868-qfdxri93	168	52	expanded	expand	VBN
cord-288868-qfdxri93	168	53	in	in	IN
cord-288868-qfdxri93	168	54	vitro	vitro	FW
cord-288868-qfdxri93	168	55	,	,	,
cord-288868-qfdxri93	168	56	the	the	DT
cord-288868-qfdxri93	168	57	authors	author	NNS
cord-288868-qfdxri93	168	58	identified	identify	VBD
cord-288868-qfdxri93	168	59	a	a	DT
cord-288868-qfdxri93	168	60	conserved	conserved	JJ
cord-288868-qfdxri93	168	61	CD4	CD4	NNP
cord-288868-qfdxri93	168	62	+	+	CC
cord-288868-qfdxri93	168	63	T	t	NN
cord-288868-qfdxri93	168	64	cell	cell	NN
cord-288868-qfdxri93	168	65	epitope	epitope	NN
cord-288868-qfdxri93	168	66	in	in	IN
cord-288868-qfdxri93	168	67	the	the	DT
cord-288868-qfdxri93	168	68	circumsporozoite	circumsporozoite	JJ
cord-288868-qfdxri93	168	69	protein	protein	NN
cord-288868-qfdxri93	168	70	with	with	IN
cord-288868-qfdxri93	168	71	predictive	predictive	JJ
cord-288868-qfdxri93	168	72	value	value	NN
cord-288868-qfdxri93	168	73	:	:	:
cord-288868-qfdxri93	168	74	an	an	DT
cord-288868-qfdxri93	168	75	IFN	IFN	NNP
cord-288868-qfdxri93	168	76	-	-	HYPH
cord-288868-qfdxri93	168	77	g	g	NN
cord-288868-qfdxri93	168	78	response	response	NN
cord-288868-qfdxri93	168	79	of	of	IN
cord-288868-qfdxri93	168	80	CD4	CD4	NNP
cord-288868-qfdxri93	168	81	+	+	CC
cord-288868-qfdxri93	168	82	T	T	NNP
cord-288868-qfdxri93	168	83	cells	cell	NNS
cord-288868-qfdxri93	168	84	to	to	IN
cord-288868-qfdxri93	168	85	this	this	DT
cord-288868-qfdxri93	168	86	epitope	epitope	NN
cord-288868-qfdxri93	168	87	positively	positively	RB
cord-288868-qfdxri93	168	88	correlated	correlate	VBN
cord-288868-qfdxri93	168	89	with	with	IN
cord-288868-qfdxri93	168	90	protection	protection	NN
cord-288868-qfdxri93	168	91	from	from	IN
cord-288868-qfdxri93	168	92	malaria	malaria	NN
cord-288868-qfdxri93	168	93	Third	Third	NNP
cord-288868-qfdxri93	168	94	meeting	meeting	NN
cord-288868-qfdxri93	168	95	on	on	IN
cord-288868-qfdxri93	168	96	Novel	Novel	NNP
cord-288868-qfdxri93	168	97	Adjuvants	Adjuvants	NNPS
cord-288868-qfdxri93	168	98	Currently	currently	RB
cord-288868-qfdxri93	168	99	in	in	IN
cord-288868-qfdxri93	168	100	or	or	CC
cord-288868-qfdxri93	168	101	Close	close	RB
cord-288868-qfdxri93	168	102	to	to	IN
cord-288868-qfdxri93	168	103	Clinical	clinical	JJ
cord-288868-qfdxri93	168	104	Testing	Testing	NNP
cord-288868-qfdxri93	168	105	World	World	NNP
cord-288868-qfdxri93	168	106	Health	Health	NNP
cord-288868-qfdxri93	168	107	Organization	Organization	NNP
cord-288868-qfdxri93	168	108	-	-	HYPH
cord-288868-qfdxri93	168	109	Organisation	Organisation	NNP
cord-288868-qfdxri93	168	110	Mondiale	Mondiale	NNP
cord-288868-qfdxri93	168	111	de	de	NNP
cord-288868-qfdxri93	168	112	la	la	NNP
cord-288868-qfdxri93	168	113	Sante	Sante	NNP
cord-288868-qfdxri93	168	114	4th	4th	JJ
cord-288868-qfdxri93	168	115	meeting	meeting	NN
cord-288868-qfdxri93	168	116	on	on	IN
cord-288868-qfdxri93	168	117	Novel	Novel	NNP
cord-288868-qfdxri93	168	118	Adjuvants	Adjuvants	NNPS
cord-288868-qfdxri93	168	119	Currently	currently	RB
cord-288868-qfdxri93	168	120	in	in	IN
cord-288868-qfdxri93	168	121	/	/	SYM
cord-288868-qfdxri93	168	122	close	close	RB
cord-288868-qfdxri93	168	123	to	to	IN
cord-288868-qfdxri93	168	124	Human	Human	NNP
cord-288868-qfdxri93	168	125	Clinical	Clinical	NNP
cord-288868-qfdxri93	168	126	Testing	Testing	NNP
cord-288868-qfdxri93	168	127	World	World	NNP
cord-288868-qfdxri93	168	128	Health	Health	NNP
cord-288868-qfdxri93	168	129	Organizationorganisation	Organizationorganisation	NNP
cord-288868-qfdxri93	168	130	Mondiale	Mondiale	NNP
cord-288868-qfdxri93	168	131	de	de	FW
cord-288868-qfdxri93	168	132	la	la	NNP
cord-288868-qfdxri93	168	133	Sante	Sante	NNP
cord-288868-qfdxri93	168	134	Fondation	Fondation	NNP
cord-288868-qfdxri93	168	135	Merieux	Merieux	NNP
cord-288868-qfdxri93	168	136	Use	Use	NNP
cord-288868-qfdxri93	168	137	of	of	IN
cord-288868-qfdxri93	168	138	CpG	CpG	NNP
cord-288868-qfdxri93	168	139	oligodeoxynucleotides	oligodeoxynucleotides	NNP
cord-288868-qfdxri93	168	140	as	as	IN
cord-288868-qfdxri93	168	141	immune	immune	JJ
cord-288868-qfdxri93	168	142	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	169	1	A	a	DT
cord-288868-qfdxri93	169	2	phase	phase	NN
cord-288868-qfdxri93	169	3	I	-PRON-	PRP
cord-288868-qfdxri93	169	4	study	study	VBP
cord-288868-qfdxri93	169	5	of	of	IN
cord-288868-qfdxri93	169	6	the	the	DT
cord-288868-qfdxri93	169	7	safety	safety	NN
cord-288868-qfdxri93	169	8	and	and	CC
cord-288868-qfdxri93	169	9	immunogenicity	immunogenicity	NN
cord-288868-qfdxri93	169	10	of	of	IN
cord-288868-qfdxri93	169	11	recombinant	recombinant	JJ
cord-288868-qfdxri93	169	12	hepatitis	hepatitis	NN
cord-288868-qfdxri93	169	13	B	B	NNP
cord-288868-qfdxri93	169	14	surface	surface	NN
cord-288868-qfdxri93	169	15	antigen	antigen	NN
cord-288868-qfdxri93	169	16	co	co	NNS
cord-288868-qfdxri93	169	17	-	-	VBN
cord-288868-qfdxri93	169	18	administered	administer	VBN
cord-288868-qfdxri93	169	19	with	with	IN
cord-288868-qfdxri93	169	20	an	an	DT
cord-288868-qfdxri93	169	21	immunostimulatory	immunostimulatory	NN
cord-288868-qfdxri93	169	22	phosphorothioate	phosphorothioate	NN
cord-288868-qfdxri93	169	23	oligonucleotide	oligonucleotide	IN
cord-288868-qfdxri93	169	24	adjuvant	adjuvant	NN
cord-288868-qfdxri93	169	25	CPG	CPG	NNP
cord-288868-qfdxri93	169	26	7909	7909	CD
cord-288868-qfdxri93	169	27	,	,	,
cord-288868-qfdxri93	169	28	an	an	DT
cord-288868-qfdxri93	169	29	immunostimulatory	immunostimulatory	JJ
cord-288868-qfdxri93	169	30	TLR9	TLR9	NNP
cord-288868-qfdxri93	169	31	agonist	agonist	NN
cord-288868-qfdxri93	169	32	oligodeoxynucleotide	oligodeoxynucleotide	NN
cord-288868-qfdxri93	169	33	,	,	,
cord-288868-qfdxri93	169	34	as	as	IN
cord-288868-qfdxri93	169	35	adjuvant	adjuvant	JJ
cord-288868-qfdxri93	169	36	to	to	IN
cord-288868-qfdxri93	169	37	engerix	engerix	NNP
cord-288868-qfdxri93	169	38	-	-	HYPH
cord-288868-qfdxri93	169	39	B((R	B((R	NNS
cord-288868-qfdxri93	169	40	)	)	-RRB-
cord-288868-qfdxri93	169	41	)	)	-RRB-
cord-288868-qfdxri93	170	1	HBV	HBV	NNP
cord-288868-qfdxri93	170	2	vaccine	vaccine	NN
cord-288868-qfdxri93	170	3	in	in	IN
cord-288868-qfdxri93	170	4	healthy	healthy	JJ
cord-288868-qfdxri93	170	5	adults	adult	NNS
cord-288868-qfdxri93	170	6	:	:	:
cord-288868-qfdxri93	170	7	a	a	DT
cord-288868-qfdxri93	170	8	double	double	JJ
cord-288868-qfdxri93	170	9	-	-	HYPH
cord-288868-qfdxri93	170	10	blind	blind	JJ
cord-288868-qfdxri93	170	11	phase	phase	NN
cord-288868-qfdxri93	170	12	I	i	NN
cord-288868-qfdxri93	170	13	/	/	SYM
cord-288868-qfdxri93	170	14	II	II	NNP
cord-288868-qfdxri93	171	1	study	study	NN
cord-288868-qfdxri93	171	2	See	see	VB
cord-288868-qfdxri93	171	3	annotation	annotation	NN
cord-288868-qfdxri93	171	4	to	to	IN
cord-288868-qfdxri93	171	5	Co	Co	NNP
cord-288868-qfdxri93	171	6	-	-	NN
cord-288868-qfdxri93	171	7	administration	administration	NNP
cord-288868-qfdxri93	171	8	of	of	IN
cord-288868-qfdxri93	171	9	CpG	CpG	NNP
cord-288868-qfdxri93	171	10	oligonucleotides	oligonucleotides	NNP
cord-288868-qfdxri93	171	11	enhances	enhance	VBZ
cord-288868-qfdxri93	171	12	the	the	DT
cord-288868-qfdxri93	171	13	late	late	JJ
cord-288868-qfdxri93	171	14	affinity	affinity	NN
cord-288868-qfdxri93	171	15	maturation	maturation	NN
cord-288868-qfdxri93	171	16	process	process	NN
cord-288868-qfdxri93	171	17	of	of	IN
cord-288868-qfdxri93	171	18	human	human	JJ
cord-288868-qfdxri93	171	19	anti	anti	JJ
cord-288868-qfdxri93	171	20	-	-	JJ
cord-288868-qfdxri93	171	21	hepatitis	hepatitis	JJ
cord-288868-qfdxri93	171	22	B	B	NNP
cord-288868-qfdxri93	171	23	vaccine	vaccine	NN
cord-288868-qfdxri93	171	24	response	response	NN
cord-288868-qfdxri93	172	1	In	in	IN
cord-288868-qfdxri93	172	2	these	these	DT
cord-288868-qfdxri93	172	3	two	two	CD
cord-288868-qfdxri93	172	4	clinical	clinical	JJ
cord-288868-qfdxri93	172	5	trials	trial	NNS
cord-288868-qfdxri93	172	6	,	,	,
cord-288868-qfdxri93	172	7	CpG	CpG	NNP
cord-288868-qfdxri93	172	8	was	be	VBD
cord-288868-qfdxri93	172	9	shown	show	VBN
cord-288868-qfdxri93	172	10	to	to	TO
cord-288868-qfdxri93	172	11	be	be	VB
cord-288868-qfdxri93	172	12	an	an	DT
cord-288868-qfdxri93	172	13	efficient	efficient	JJ
cord-288868-qfdxri93	172	14	adjuvant	adjuvant	NN
cord-288868-qfdxri93	172	15	when	when	WRB
cord-288868-qfdxri93	172	16	used	use	VBN
cord-288868-qfdxri93	172	17	in	in	IN
cord-288868-qfdxri93	172	18	combination	combination	NN
cord-288868-qfdxri93	172	19	with	with	IN
cord-288868-qfdxri93	172	20	licensed	licensed	JJ
cord-288868-qfdxri93	172	21	vaccines	vaccine	NNS
cord-288868-qfdxri93	173	1	The	the	DT
cord-288868-qfdxri93	173	2	immunogenicity	immunogenicity	NN
cord-288868-qfdxri93	173	3	and	and	CC
cord-288868-qfdxri93	173	4	reactogenicity	reactogenicity	NN
cord-288868-qfdxri93	173	5	profile	profile	NN
cord-288868-qfdxri93	173	6	of	of	IN
cord-288868-qfdxri93	173	7	a	a	DT
cord-288868-qfdxri93	173	8	candidate	candidate	NN
cord-288868-qfdxri93	173	9	hepatitis	hepatitis	NN
cord-288868-qfdxri93	173	10	B	B	NNP
cord-288868-qfdxri93	173	11	vaccine	vaccine	NN
cord-288868-qfdxri93	173	12	in	in	IN
cord-288868-qfdxri93	173	13	an	an	DT
cord-288868-qfdxri93	173	14	adult	adult	NN
cord-288868-qfdxri93	173	15	vaccine	vaccine	NN
cord-288868-qfdxri93	173	16	non	non	JJ
cord-288868-qfdxri93	173	17	-	-	JJ
cord-288868-qfdxri93	173	18	responder	responder	JJ
cord-288868-qfdxri93	173	19	population	population	NN
cord-288868-qfdxri93	173	20	Induced	induce	VBN
cord-288868-qfdxri93	173	21	recruitment	recruitment	NN
cord-288868-qfdxri93	173	22	of	of	IN
cord-288868-qfdxri93	173	23	NK	NK	NNP
cord-288868-qfdxri93	173	24	cells	cell	NNS
cord-288868-qfdxri93	173	25	to	to	IN
cord-288868-qfdxri93	173	26	lymph	lymph	NN
cord-288868-qfdxri93	173	27	nodes	node	NNS
cord-288868-qfdxri93	173	28	provides	provide	VBZ
cord-288868-qfdxri93	173	29	IFN	IFN	NNP
cord-288868-qfdxri93	173	30	-	-	HYPH
cord-288868-qfdxri93	173	31	gamma	gamma	NN
cord-288868-qfdxri93	173	32	for	for	IN
cord-288868-qfdxri93	173	33	T(H)1	t(h)1	JJ
cord-288868-qfdxri93	173	34	priming	priming	NN
cord-288868-qfdxri93	174	1	The	the	DT
cord-288868-qfdxri93	174	2	authors	author	NNS
cord-288868-qfdxri93	174	3	showed	show	VBD
cord-288868-qfdxri93	174	4	that	that	IN
cord-288868-qfdxri93	174	5	the	the	DT
cord-288868-qfdxri93	174	6	ability	ability	NN
cord-288868-qfdxri93	174	7	of	of	IN
cord-288868-qfdxri93	174	8	some	some	DT
cord-288868-qfdxri93	174	9	adjuvants	adjuvant	NNS
cord-288868-qfdxri93	174	10	to	to	TO
cord-288868-qfdxri93	174	11	induce	induce	VB
cord-288868-qfdxri93	174	12	Th1	th1	NN
cord-288868-qfdxri93	174	13	priming	priming	NN
cord-288868-qfdxri93	174	14	correlates	correlate	VBZ
cord-288868-qfdxri93	174	15	with	with	IN
cord-288868-qfdxri93	174	16	the	the	DT
cord-288868-qfdxri93	174	17	degree	degree	NN
cord-288868-qfdxri93	174	18	of	of	IN
cord-288868-qfdxri93	174	19	recruitment	recruitment	NN
cord-288868-qfdxri93	174	20	of	of	IN
cord-288868-qfdxri93	174	21	NK	NK	NNP
cord-288868-qfdxri93	174	22	cells	cell	NNS
cord-288868-qfdxri93	174	23	,	,	,
cord-288868-qfdxri93	174	24	which	which	WDT
cord-288868-qfdxri93	174	25	represent	represent	VBP
cord-288868-qfdxri93	174	26	an	an	DT
cord-288868-qfdxri93	174	27	early	early	JJ
cord-288868-qfdxri93	174	28	source	source	NN
cord-288868-qfdxri93	174	29	of	of	IN
cord-288868-qfdxri93	174	30	IFN	IFN	NNP
cord-288868-qfdxri93	174	31	-	-	HYPH
cord-288868-qfdxri93	174	32	g	g	NNP
cord-288868-qfdxri93	174	33	.	.	.
cord-288868-qfdxri93	175	1	This	this	DT
cord-288868-qfdxri93	175	2	might	may	MD
cord-288868-qfdxri93	175	3	provide	provide	VB
cord-288868-qfdxri93	175	4	a	a	DT
cord-288868-qfdxri93	175	5	rationale	rationale	NN
cord-288868-qfdxri93	175	6	for	for	IN
cord-288868-qfdxri93	175	7	the	the	DT
cord-288868-qfdxri93	175	8	search	search	NN
cord-288868-qfdxri93	175	9	for	for	IN
cord-288868-qfdxri93	175	10	efficient	efficient	JJ
cord-288868-qfdxri93	175	11	Th1	th1	CD
cord-288868-qfdxri93	175	12	Therapeutic	therapeutic	JJ
cord-288868-qfdxri93	175	13	cancer	cancer	NN
cord-288868-qfdxri93	175	14	vaccines	vaccine	NNS
cord-288868-qfdxri93	175	15	:	:	:
cord-288868-qfdxri93	175	16	using	use	VBG
cord-288868-qfdxri93	175	17	unique	unique	JJ
cord-288868-qfdxri93	175	18	antigens	antigen	NNS
cord-288868-qfdxri93	175	19	Therapeutic	therapeutic	JJ
cord-288868-qfdxri93	175	20	dendritic	dendritic	JJ
cord-288868-qfdxri93	175	21	-	-	HYPH
cord-288868-qfdxri93	175	22	cell	cell	NN
cord-288868-qfdxri93	175	23	vaccine	vaccine	NN
cord-288868-qfdxri93	175	24	for	for	IN
cord-288868-qfdxri93	175	25	chronic	chronic	JJ
cord-288868-qfdxri93	175	26	HIV-1	HIV-1	NNP
cord-288868-qfdxri93	175	27	infection	infection	NN
cord-288868-qfdxri93	176	1	This	this	DT
cord-288868-qfdxri93	176	2	study	study	NN
cord-288868-qfdxri93	176	3	followed	follow	VBD
cord-288868-qfdxri93	176	4	a	a	DT
cord-288868-qfdxri93	176	5	previous	previous	JJ
cord-288868-qfdxri93	176	6	one	one	NN
cord-288868-qfdxri93	176	7	in	in	IN
cord-288868-qfdxri93	176	8	macaques	macaque	NNS
cord-288868-qfdxri93	176	9	[	[	-LRB-
cord-288868-qfdxri93	176	10	42	42	CD
cord-288868-qfdxri93	176	11	]	]	-RRB-
cord-288868-qfdxri93	176	12	and	and	CC
cord-288868-qfdxri93	176	13	showed	show	VBD
cord-288868-qfdxri93	176	14	that	that	IN
cord-288868-qfdxri93	176	15	injection	injection	NN
cord-288868-qfdxri93	176	16	of	of	IN
cord-288868-qfdxri93	176	17	autologous	autologous	JJ
cord-288868-qfdxri93	176	18	DCs	dc	NNS
cord-288868-qfdxri93	176	19	loaded	load	VBN
cord-288868-qfdxri93	176	20	with	with	IN
cord-288868-qfdxri93	176	21	autologous	autologous	JJ
cord-288868-qfdxri93	176	22	inactivated	inactivate	VBN
cord-288868-qfdxri93	176	23	HIV	HIV	NNP
cord-288868-qfdxri93	176	24	induces	induce	VBZ
cord-288868-qfdxri93	176	25	HIV	HIV	NNP
cord-288868-qfdxri93	176	26	-	-	HYPH
cord-288868-qfdxri93	176	27	specific	specific	JJ
cord-288868-qfdxri93	176	28	CD4	CD4	NNP
cord-288868-qfdxri93	176	29	+	+	CC
cord-288868-qfdxri93	176	30	and	and	CC
cord-288868-qfdxri93	176	31	CD8	CD8	NNP
cord-288868-qfdxri93	176	32	+	+	CC
cord-288868-qfdxri93	176	33	T	T	NNP
cord-288868-qfdxri93	176	34	cell	cell	NN
cord-288868-qfdxri93	176	35	responses	response	NNS
cord-288868-qfdxri93	176	36	and	and	CC
cord-288868-qfdxri93	176	37	leads	lead	VBZ
cord-288868-qfdxri93	176	38	to	to	IN
cord-288868-qfdxri93	176	39	a	a	DT
cord-288868-qfdxri93	176	40	prolonged	prolong	VBN
cord-288868-qfdxri93	176	41	tenfold	tenfold	NN
cord-288868-qfdxri93	176	42	reduction	reduction	NN
cord-288868-qfdxri93	176	43	in	in	IN
cord-288868-qfdxri93	176	44	virus	virus	NN
cord-288868-qfdxri93	176	45	Therapeutic	therapeutic	JJ
cord-288868-qfdxri93	176	46	dendritic	dendritic	JJ
cord-288868-qfdxri93	176	47	-	-	HYPH
cord-288868-qfdxri93	176	48	cell	cell	NN
cord-288868-qfdxri93	176	49	vaccine	vaccine	NN
cord-288868-qfdxri93	176	50	for	for	IN
cord-288868-qfdxri93	176	51	simian	simian	JJ
cord-288868-qfdxri93	176	52	AIDS	AIDS	NNP
cord-288868-qfdxri93	176	53	Dendritic	Dendritic	NNP
cord-288868-qfdxri93	176	54	cells	cell	NNS
cord-288868-qfdxri93	176	55	:	:	:
cord-288868-qfdxri93	176	56	a	a	DT
cord-288868-qfdxri93	176	57	journey	journey	NN
cord-288868-qfdxri93	176	58	from	from	IN
cord-288868-qfdxri93	176	59	laboratory	laboratory	NN
cord-288868-qfdxri93	176	60	to	to	TO
cord-288868-qfdxri93	176	61	clinic	clinic	VB
cord-288868-qfdxri93	176	62	Dendritic	dendritic	JJ
cord-288868-qfdxri93	176	63	cells	cell	NNS
cord-288868-qfdxri93	176	64	transfected	transfecte	VBN
cord-288868-qfdxri93	176	65	with	with	IN
cord-288868-qfdxri93	176	66	cytopathic	cytopathic	JJ
cord-288868-qfdxri93	176	67	self	self	NN
cord-288868-qfdxri93	176	68	-	-	HYPH
cord-288868-qfdxri93	176	69	replicating	replicate	VBG
cord-288868-qfdxri93	176	70	RNA	RNA	NNP
cord-288868-qfdxri93	176	71	induce	induce	VB
cord-288868-qfdxri93	176	72	crosspriming	crosspriming	NN
cord-288868-qfdxri93	176	73	of	of	IN
cord-288868-qfdxri93	176	74	CD8	CD8	NNP
cord-288868-qfdxri93	176	75	+	+	CC
cord-288868-qfdxri93	176	76	T	T	NNP
cord-288868-qfdxri93	176	77	cells	cell	NNS
cord-288868-qfdxri93	176	78	and	and	CC
cord-288868-qfdxri93	176	79	antiviral	antiviral	JJ
cord-288868-qfdxri93	176	80	immunity	immunity	NN
cord-288868-qfdxri93	177	1	The	the	DT
cord-288868-qfdxri93	177	2	surprising	surprising	JJ
cord-288868-qfdxri93	177	3	observation	observation	NN
cord-288868-qfdxri93	177	4	in	in	IN
cord-288868-qfdxri93	177	5	this	this	DT
cord-288868-qfdxri93	177	6	study	study	NN
cord-288868-qfdxri93	177	7	is	be	VBZ
cord-288868-qfdxri93	177	8	that	that	IN
cord-288868-qfdxri93	177	9	induction	induction	NN
cord-288868-qfdxri93	177	10	of	of	IN
cord-288868-qfdxri93	177	11	immunity	immunity	NN
cord-288868-qfdxri93	177	12	and	and	CC
cord-288868-qfdxri93	177	13	crosspresentation	crosspresentation	NN
cord-288868-qfdxri93	177	14	of	of	IN
cord-288868-qfdxri93	177	15	antigen	antigen	NNP
cord-288868-qfdxri93	177	16	is	be	VBZ
cord-288868-qfdxri93	177	17	greatly	greatly	RB
cord-288868-qfdxri93	177	18	facilitated	facilitate	VBN
cord-288868-qfdxri93	177	19	by	by	IN
cord-288868-qfdxri93	177	20	the	the	DT
cord-288868-qfdxri93	177	21	death	death	NN
cord-288868-qfdxri93	177	22	of	of	IN
cord-288868-qfdxri93	177	23	the	the	DT
cord-288868-qfdxri93	177	24	injected	inject	VBN
cord-288868-qfdxri93	177	25	antigen	antigen	NN
cord-288868-qfdxri93	177	26	-	-	HYPH
cord-288868-qfdxri93	177	27	carrying	carry	VBG
cord-288868-qfdxri93	177	28	DCs	dc	NNS
cord-288868-qfdxri93	177	29	.	.	.
cord-288868-qfdxri93	178	1	This	this	DT
cord-288868-qfdxri93	178	2	suggests	suggest	VBZ
cord-288868-qfdxri93	178	3	that	that	IN
cord-288868-qfdxri93	178	4	danger	danger	NN
cord-288868-qfdxri93	178	5	signals	signal	NNS
cord-288868-qfdxri93	178	6	from	from	IN
cord-288868-qfdxri93	178	7	dying	die	VBG
cord-288868-qfdxri93	178	8	cells	cell	NNS
cord-288868-qfdxri93	178	9	might	may	MD
cord-288868-qfdxri93	178	10	have	have	VB
cord-288868-qfdxri93	178	11	an	an	DT
cord-288868-qfdxri93	178	12	adjuvant	adjuvant	JJ
cord-288868-qfdxri93	178	13	effect	effect	NN
cord-288868-qfdxri93	178	14	in	in	IN
cord-288868-qfdxri93	178	15	vaccinations	vaccination	NNS
cord-288868-qfdxri93	178	16	,	,	,
cord-288868-qfdxri93	178	17	as	as	RB
cord-288868-qfdxri93	178	18	well	well	RB
cord-288868-qfdxri93	178	19	as	as	IN
cord-288868-qfdxri93	178	20	in	in	IN
cord-288868-qfdxri93	178	21	immune	immune	JJ
cord-288868-qfdxri93	178	22	responses	response	NNS
cord-288868-qfdxri93	178	23	Apoptosis	Apoptosis	NNP
cord-288868-qfdxri93	178	24	facilitates	facilitate	VBZ
cord-288868-qfdxri93	178	25	antigen	antigen	NN
cord-288868-qfdxri93	178	26	presentation	presentation	NN
cord-288868-qfdxri93	178	27	to	to	IN
cord-288868-qfdxri93	178	28	T	T	NNP
cord-288868-qfdxri93	178	29	lymphocytes	lymphocyte	NNS
cord-288868-qfdxri93	178	30	through	through	IN
cord-288868-qfdxri93	178	31	MHC	MHC	NNP
cord-288868-qfdxri93	178	32	-	-	HYPH
cord-288868-qfdxri93	178	33	I	I	NNP
cord-288868-qfdxri93	178	34	and	and	CC
cord-288868-qfdxri93	178	35	CD1	CD1	NNP
cord-288868-qfdxri93	178	36	in	in	IN
cord-288868-qfdxri93	178	37	tuberculosis	tuberculosis	NN
cord-288868-qfdxri93	178	38	Molecular	molecular	JJ
cord-288868-qfdxri93	178	39	identification	identification	NN
cord-288868-qfdxri93	178	40	of	of	IN
cord-288868-qfdxri93	178	41	a	a	DT
cord-288868-qfdxri93	178	42	danger	danger	NN
cord-288868-qfdxri93	178	43	signal	signal	NN
cord-288868-qfdxri93	178	44	that	that	WDT
cord-288868-qfdxri93	178	45	alerts	alert	VBZ
cord-288868-qfdxri93	178	46	the	the	DT
cord-288868-qfdxri93	178	47	immune	immune	JJ
cord-288868-qfdxri93	178	48	system	system	NN
cord-288868-qfdxri93	178	49	to	to	IN
cord-288868-qfdxri93	178	50	dying	die	VBG
cord-288868-qfdxri93	178	51	cells	cell	NNS
cord-288868-qfdxri93	178	52	Microparticles	microparticle	NNS
cord-288868-qfdxri93	178	53	for	for	IN
cord-288868-qfdxri93	178	54	the	the	DT
cord-288868-qfdxri93	178	55	delivery	delivery	NN
cord-288868-qfdxri93	178	56	of	of	IN
cord-288868-qfdxri93	178	57	DNA	dna	NN
cord-288868-qfdxri93	178	58	vaccines	vaccine	NNS
cord-288868-qfdxri93	179	1	Enhanced	enhanced	JJ
cord-288868-qfdxri93	179	2	T	t	NN
cord-288868-qfdxri93	179	3	-	-	HYPH
cord-288868-qfdxri93	179	4	cell	cell	NN
cord-288868-qfdxri93	179	5	immunogenicity	immunogenicity	NN
cord-288868-qfdxri93	179	6	of	of	IN
cord-288868-qfdxri93	179	7	plasmid	plasmid	NN
cord-288868-qfdxri93	179	8	DNA	dna	NN
cord-288868-qfdxri93	179	9	vaccines	vaccine	NNS
cord-288868-qfdxri93	179	10	boosted	boost	VBN
cord-288868-qfdxri93	179	11	by	by	IN
cord-288868-qfdxri93	179	12	recombinant	recombinant	JJ
cord-288868-qfdxri93	179	13	modified	modify	VBN
cord-288868-qfdxri93	179	14	vaccinia	vaccinia	NN
cord-288868-qfdxri93	179	15	virus	virus	NN
cord-288868-qfdxri93	179	16	Ankara	Ankara	NNP
cord-288868-qfdxri93	179	17	in	in	IN
cord-288868-qfdxri93	179	18	humans	human	NNS
cord-288868-qfdxri93	179	19	Safety	Safety	NNP
cord-288868-qfdxri93	179	20	and	and	CC
cord-288868-qfdxri93	179	21	immunogenicity	immunogenicity	NN
cord-288868-qfdxri93	179	22	of	of	IN
cord-288868-qfdxri93	179	23	DNA	dna	NN
cord-288868-qfdxri93	179	24	/	/	SYM
cord-288868-qfdxri93	179	25	modified	modify	VBN
cord-288868-qfdxri93	179	26	vaccinia	vaccinia	NN
cord-288868-qfdxri93	179	27	virus	virus	NN
cord-288868-qfdxri93	179	28	ankara	ankara	NNP
cord-288868-qfdxri93	179	29	malaria	malaria	NNP
cord-288868-qfdxri93	179	30	vaccination	vaccination	NN
cord-288868-qfdxri93	179	31	in	in	IN
cord-288868-qfdxri93	179	32	African	african	JJ
cord-288868-qfdxri93	179	33	adults	adult	NNS
cord-288868-qfdxri93	180	1	A	a	DT
cord-288868-qfdxri93	180	2	randomised	randomised	JJ
cord-288868-qfdxri93	180	3	,	,	,
cord-288868-qfdxri93	180	4	double	double	JJ
cord-288868-qfdxri93	180	5	-	-	HYPH
cord-288868-qfdxri93	180	6	blind	blind	JJ
cord-288868-qfdxri93	180	7	,	,	,
cord-288868-qfdxri93	180	8	controlled	controlled	JJ
cord-288868-qfdxri93	180	9	vaccine	vaccine	NN
cord-288868-qfdxri93	180	10	efficacy	efficacy	NN
cord-288868-qfdxri93	180	11	trial	trial	NN
cord-288868-qfdxri93	180	12	of	of	IN
cord-288868-qfdxri93	180	13	DNA	DNA	NNP
cord-288868-qfdxri93	180	14	/	/	SYM
cord-288868-qfdxri93	180	15	MVA	MVA	NNP
cord-288868-qfdxri93	180	16	ME	ME	NNP
cord-288868-qfdxri93	180	17	-	-	HYPH
cord-288868-qfdxri93	180	18	TRAP	trap	VB
cord-288868-qfdxri93	180	19	against	against	IN
cord-288868-qfdxri93	180	20	malaria	malaria	NN
cord-288868-qfdxri93	180	21	infection	infection	NN
cord-288868-qfdxri93	180	22	in	in	IN
cord-288868-qfdxri93	180	23	Gambian	gambian	JJ
cord-288868-qfdxri93	180	24	adults	adult	NNS
cord-288868-qfdxri93	181	1	Recombinant	recombinant	JJ
cord-288868-qfdxri93	181	2	modified	modify	VBN
cord-288868-qfdxri93	181	3	vaccinia	vaccinia	NN
cord-288868-qfdxri93	181	4	virus	virus	NN
cord-288868-qfdxri93	181	5	Ankara	Ankara	NNP
cord-288868-qfdxri93	181	6	expressing	express	VBG
cord-288868-qfdxri93	181	7	antigen	antigen	NN
cord-288868-qfdxri93	181	8	85A	85A	NNP
cord-288868-qfdxri93	181	9	boosts	boost	VBZ
cord-288868-qfdxri93	181	10	BCG	BCG	NNP
cord-288868-qfdxri93	181	11	-	-	HYPH
cord-288868-qfdxri93	181	12	primed	prime	VBN
cord-288868-qfdxri93	181	13	and	and	CC
cord-288868-qfdxri93	181	14	naturally	naturally	RB
cord-288868-qfdxri93	181	15	acquired	acquire	VBN
cord-288868-qfdxri93	181	16	antimycobacterial	antimycobacterial	JJ
cord-288868-qfdxri93	181	17	immunity	immunity	NN
cord-288868-qfdxri93	181	18	in	in	IN
cord-288868-qfdxri93	181	19	humans	human	NNS
cord-288868-qfdxri93	182	1	The	the	DT
cord-288868-qfdxri93	182	2	authors	author	NNS
cord-288868-qfdxri93	182	3	observed	observe	VBD
cord-288868-qfdxri93	182	4	antigen	antigen	NN
cord-288868-qfdxri93	182	5	-	-	HYPH
cord-288868-qfdxri93	182	6	specific	specific	JJ
cord-288868-qfdxri93	182	7	IFN	IFN	NNP
cord-288868-qfdxri93	182	8	-	-	HYPH
cord-288868-qfdxri93	182	9	g	g	NNP
cord-288868-qfdxri93	182	10	responses	response	NNS
cord-288868-qfdxri93	182	11	of	of	IN
cord-288868-qfdxri93	182	12	short	short	JJ
cord-288868-qfdxri93	182	13	duration	duration	NN
cord-288868-qfdxri93	182	14	induced	induce	VBN
cord-288868-qfdxri93	182	15	by	by	IN
cord-288868-qfdxri93	182	16	vaccination	vaccination	NN
cord-288868-qfdxri93	182	17	with	with	IN
cord-288868-qfdxri93	182	18	MVA	MVA	NNP
cord-288868-qfdxri93	182	19	expressing	express	VBG
cord-288868-qfdxri93	182	20	the	the	DT
cord-288868-qfdxri93	182	21	conserved	conserve	VBN
cord-288868-qfdxri93	182	22	mycobacterial	mycobacterial	JJ
cord-288868-qfdxri93	182	23	antigen	antigen	NNP
cord-288868-qfdxri93	182	24	85A.	85A.	.
cord-288868-qfdxri93	183	1	This	this	DT
cord-288868-qfdxri93	183	2	T	t	NN
cord-288868-qfdxri93	183	3	cell	cell	NN
cord-288868-qfdxri93	183	4	response	response	NN
cord-288868-qfdxri93	183	5	is	be	VBZ
cord-288868-qfdxri93	183	6	substantially	substantially	RB
cord-288868-qfdxri93	183	7	higher	high	JJR
cord-288868-qfdxri93	183	8	and	and	CC
cord-288868-qfdxri93	183	9	sustained	sustain	VBN
cord-288868-qfdxri93	183	10	in	in	IN
cord-288868-qfdxri93	183	11	vaccinees	vaccinee	NNS
cord-288868-qfdxri93	183	12	who	who	WP
cord-288868-qfdxri93	183	13	received	receive	VBD
cord-288868-qfdxri93	183	14	bacillus	bacillus	NN
cord-288868-qfdxri93	183	15	Calmette	Calmette	NNP
cord-288868-qfdxri93	183	16	-	-	HYPH
cord-288868-qfdxri93	183	17	Guerin	Guerin	NNP
cord-288868-qfdxri93	183	18	followed	follow	VBD
cord-288868-qfdxri93	183	19	by	by	IN
cord-288868-qfdxri93	183	20	MVA	MVA	NNP
cord-288868-qfdxri93	183	21	three	three	CD
cord-288868-qfdxri93	183	22	weeks	week	NNS
cord-288868-qfdxri93	183	23	later	later	RB
cord-288868-qfdxri93	183	24	Gene	gene	NN
cord-288868-qfdxri93	183	25	-	-	HYPH
cord-288868-qfdxri93	183	26	based	base	VBN
cord-288868-qfdxri93	183	27	vaccines	vaccine	NNS
cord-288868-qfdxri93	183	28	and	and	CC
cord-288868-qfdxri93	183	29	immunotherapeutics	immunotherapeutic	NNS
cord-288868-qfdxri93	183	30	DNA	DNA	NNP
cord-288868-qfdxri93	183	31	vaccines	vaccine	NNS
cord-288868-qfdxri93	183	32	to	to	TO
cord-288868-qfdxri93	183	33	attack	attack	VB
cord-288868-qfdxri93	183	34	cancer	cancer	NN
cord-288868-qfdxri93	183	35	Persistent	Persistent	NNP
cord-288868-qfdxri93	183	36	Toll	Toll	NNP
cord-288868-qfdxri93	183	37	-	-	HYPH
cord-288868-qfdxri93	183	38	like	like	JJ
cord-288868-qfdxri93	183	39	receptor	receptor	NN
cord-288868-qfdxri93	183	40	signals	signal	NNS
cord-288868-qfdxri93	183	41	are	be	VBP
cord-288868-qfdxri93	183	42	required	require	VBN
cord-288868-qfdxri93	183	43	for	for	IN
cord-288868-qfdxri93	183	44	reversal	reversal	NN
cord-288868-qfdxri93	183	45	of	of	IN
cord-288868-qfdxri93	183	46	regulatory	regulatory	JJ
cord-288868-qfdxri93	183	47	T	t	NN
cord-288868-qfdxri93	183	48	cell	cell	NN
cord-288868-qfdxri93	183	49	-	-	HYPH
cord-288868-qfdxri93	183	50	mediated	mediate	VBN
cord-288868-qfdxri93	183	51	CD8	CD8	NNP
cord-288868-qfdxri93	183	52	tolerance	tolerance	NN
cord-288868-qfdxri93	183	53	This	this	DT
cord-288868-qfdxri93	183	54	transgenic	transgenic	JJ
cord-288868-qfdxri93	183	55	adoptive	adoptive	JJ
cord-288868-qfdxri93	183	56	transfer	transfer	NN
cord-288868-qfdxri93	183	57	model	model	NN
cord-288868-qfdxri93	183	58	of	of	IN
cord-288868-qfdxri93	183	59	tolerance	tolerance	NN
cord-288868-qfdxri93	183	60	enables	enable	VBZ
cord-288868-qfdxri93	183	61	the	the	DT
cord-288868-qfdxri93	183	62	comparison	comparison	NN
cord-288868-qfdxri93	183	63	of	of	IN
cord-288868-qfdxri93	183	64	different	different	JJ
cord-288868-qfdxri93	183	65	vaccine	vaccine	NN
cord-288868-qfdxri93	183	66	regimens	regimen	NNS
cord-288868-qfdxri93	183	67	in	in	IN
cord-288868-qfdxri93	183	68	their	-PRON-	PRP$
cord-288868-qfdxri93	183	69	ability	ability	NN
cord-288868-qfdxri93	183	70	to	to	TO
cord-288868-qfdxri93	183	71	break	break	VB
cord-288868-qfdxri93	183	72	tolerance	tolerance	NN
cord-288868-qfdxri93	183	73	.	.	.
cord-288868-qfdxri93	184	1	Viral	viral	JJ
cord-288868-qfdxri93	184	2	vaccines	vaccine	NNS
cord-288868-qfdxri93	184	3	are	be	VBP
cord-288868-qfdxri93	184	4	most	most	RBS
cord-288868-qfdxri93	184	5	efficient	efficient	JJ
cord-288868-qfdxri93	184	6	in	in	IN
cord-288868-qfdxri93	184	7	overcoming	overcome	VBG
cord-288868-qfdxri93	184	8	established	establish	VBN
cord-288868-qfdxri93	184	9	tolerance	tolerance	NN
cord-288868-qfdxri93	184	10	.	.	.
cord-288868-qfdxri93	185	1	DCbased	dcbased	JJ
cord-288868-qfdxri93	185	2	vaccine	vaccine	NN
cord-288868-qfdxri93	185	3	strategies	strategy	NNS
cord-288868-qfdxri93	185	4	that	that	WDT
cord-288868-qfdxri93	185	5	are	be	VBP
cord-288868-qfdxri93	185	6	Contrasting	contrast	VBG
cord-288868-qfdxri93	185	7	frequencies	frequency	NNS
cord-288868-qfdxri93	185	8	of	of	IN
cord-288868-qfdxri93	185	9	antitumor	antitumor	JJ
cord-288868-qfdxri93	185	10	and	and	CC
cord-288868-qfdxri93	185	11	anti	anti	JJ
cord-288868-qfdxri93	185	12	-	-	JJ
cord-288868-qfdxri93	185	13	vaccine	vaccine	JJ
cord-288868-qfdxri93	185	14	T	t	NN
cord-288868-qfdxri93	185	15	cells	cell	NNS
cord-288868-qfdxri93	185	16	in	in	IN
cord-288868-qfdxri93	185	17	metastases	metastasis	NNS
cord-288868-qfdxri93	185	18	of	of	IN
cord-288868-qfdxri93	185	19	a	a	DT
cord-288868-qfdxri93	185	20	melanoma	melanoma	NN
cord-288868-qfdxri93	185	21	patient	patient	NN
cord-288868-qfdxri93	185	22	vaccinated	vaccinate	VBN
cord-288868-qfdxri93	185	23	with	with	IN
cord-288868-qfdxri93	185	24	a	a	DT
cord-288868-qfdxri93	185	25	MAGE	MAGE	NNP
cord-288868-qfdxri93	185	26	tumor	tumor	NN
cord-288868-qfdxri93	185	27	antigen	antigen	NN
cord-288868-qfdxri93	185	28	High	high	JJ
cord-288868-qfdxri93	185	29	frequency	frequency	NN
cord-288868-qfdxri93	185	30	of	of	IN
cord-288868-qfdxri93	185	31	antitumor	antitumor	NN
cord-288868-qfdxri93	185	32	T	t	NN
cord-288868-qfdxri93	185	33	cells	cell	NNS
cord-288868-qfdxri93	185	34	in	in	IN
cord-288868-qfdxri93	185	35	the	the	DT
cord-288868-qfdxri93	185	36	blood	blood	NN
cord-288868-qfdxri93	185	37	of	of	IN
cord-288868-qfdxri93	185	38	melanoma	melanoma	NN
cord-288868-qfdxri93	185	39	patients	patient	NNS
cord-288868-qfdxri93	185	40	before	before	IN
cord-288868-qfdxri93	185	41	and	and	CC
cord-288868-qfdxri93	185	42	after	after	IN
cord-288868-qfdxri93	185	43	vaccination	vaccination	NN
cord-288868-qfdxri93	185	44	with	with	IN
cord-288868-qfdxri93	185	45	tumor	tumor	NN
cord-288868-qfdxri93	185	46	antigens	antigen	NNS
cord-288868-qfdxri93	186	1	These	these	DT
cord-288868-qfdxri93	186	2	two	two	CD
cord-288868-qfdxri93	186	3	studies	study	NNS
cord-288868-qfdxri93	186	4	showed	show	VBD
cord-288868-qfdxri93	186	5	that	that	IN
cord-288868-qfdxri93	186	6	in	in	IN
cord-288868-qfdxri93	186	7	the	the	DT
cord-288868-qfdxri93	186	8	blood	blood	NN
cord-288868-qfdxri93	186	9	and	and	CC
cord-288868-qfdxri93	186	10	metastases	metastasis	NNS
cord-288868-qfdxri93	186	11	of	of	IN
cord-288868-qfdxri93	186	12	vaccinated	vaccinated	JJ
cord-288868-qfdxri93	186	13	cancer	cancer	NN
cord-288868-qfdxri93	186	14	patients	patient	NNS
cord-288868-qfdxri93	186	15	,	,	,
cord-288868-qfdxri93	186	16	T	t	NN
cord-288868-qfdxri93	186	17	cells	cell	NNS
cord-288868-qfdxri93	186	18	specific	specific	JJ
cord-288868-qfdxri93	186	19	for	for	IN
cord-288868-qfdxri93	186	20	the	the	DT
cord-288868-qfdxri93	186	21	vaccine	vaccine	NN
cord-288868-qfdxri93	186	22	antigen	antigen	NN
cord-288868-qfdxri93	186	23	might	may	MD
cord-288868-qfdxri93	186	24	represent	represent	VB
cord-288868-qfdxri93	186	25	only	only	RB
cord-288868-qfdxri93	186	26	a	a	DT
cord-288868-qfdxri93	186	27	small	small	JJ
cord-288868-qfdxri93	186	28	fraction	fraction	NN
cord-288868-qfdxri93	186	29	of	of	IN
cord-288868-qfdxri93	186	30	total	total	JJ
cord-288868-qfdxri93	186	31	tumor	tumor	NN
cord-288868-qfdxri93	186	32	-	-	HYPH
cord-288868-qfdxri93	186	33	specific	specific	JJ
cord-288868-qfdxri93	186	34	T	t	NN
cord-288868-qfdxri93	186	35	cells	cell	NNS
cord-288868-qfdxri93	186	36	,	,	,
cord-288868-qfdxri93	186	37	both	both	CC
cord-288868-qfdxri93	186	38	before	before	IN
cord-288868-qfdxri93	186	39	and	and	CC
cord-288868-qfdxri93	186	40	after	after	RB
cord-288868-qfdxri93	187	1	vaccination	vaccination	NN
cord-288868-qfdxri93	187	2	A	a	DT
cord-288868-qfdxri93	187	3	synthetic	synthetic	JJ
cord-288868-qfdxri93	187	4	conjugate	conjugate	NN
cord-288868-qfdxri93	187	5	polysaccharide	polysaccharide	NN
cord-288868-qfdxri93	187	6	vaccine	vaccine	NN
cord-288868-qfdxri93	187	7	against	against	IN
cord-288868-qfdxri93	187	8	Haemophilus	Haemophilus	NNP
cord-288868-qfdxri93	187	9	influenzae	influenzae	NN
cord-288868-qfdxri93	187	10	type	type	NN
cord-288868-qfdxri93	187	11	b	b	.
cord-288868-qfdxri93	187	12	The	the	DT
cord-288868-qfdxri93	187	13	large	large	JJ
cord-288868-qfdxri93	187	14	-	-	HYPH
cord-288868-qfdxri93	187	15	scale	scale	NN
cord-288868-qfdxri93	187	16	production	production	NN
cord-288868-qfdxri93	187	17	of	of	IN
cord-288868-qfdxri93	187	18	a	a	DT
cord-288868-qfdxri93	187	19	conjugate	conjugate	JJ
cord-288868-qfdxri93	187	20	vaccine	vaccine	NN
cord-288868-qfdxri93	187	21	containing	contain	VBG
cord-288868-qfdxri93	187	22	synthetic	synthetic	JJ
cord-288868-qfdxri93	187	23	polysaccharides	polysaccharide	NNS
cord-288868-qfdxri93	187	24	has	have	VBZ
cord-288868-qfdxri93	187	25	been	be	VBN
cord-288868-qfdxri93	187	26	achieved	achieve	VBN
cord-288868-qfdxri93	187	27	by	by	IN
cord-288868-qfdxri93	187	28	simplification	simplification	NN
cord-288868-qfdxri93	187	29	of	of	IN
cord-288868-qfdxri93	187	30	the	the	DT
cord-288868-qfdxri93	187	31	polysaccharide	polysaccharide	NN
cord-288868-qfdxri93	187	32	chemistry	chemistry	NN
cord-288868-qfdxri93	187	33	involved	involve	VBN
cord-288868-qfdxri93	187	34	A	a	DT
cord-288868-qfdxri93	187	35	totally	totally	RB
cord-288868-qfdxri93	187	36	synthetic	synthetic	JJ
cord-288868-qfdxri93	187	37	vaccine	vaccine	NN
cord-288868-qfdxri93	187	38	of	of	IN
cord-288868-qfdxri93	187	39	generic	generic	JJ
cord-288868-qfdxri93	187	40	structure	structure	NN
cord-288868-qfdxri93	187	41	that	that	WDT
cord-288868-qfdxri93	187	42	targets	target	VBZ
cord-288868-qfdxri93	187	43	Toll	Toll	NNP
cord-288868-qfdxri93	187	44	-	-	HYPH
cord-288868-qfdxri93	187	45	like	like	JJ
cord-288868-qfdxri93	187	46	receptor	receptor	NN
cord-288868-qfdxri93	187	47	2	2	CD
cord-288868-qfdxri93	187	48	on	on	IN
cord-288868-qfdxri93	187	49	dendritic	dendritic	JJ
cord-288868-qfdxri93	187	50	cells	cell	NNS
cord-288868-qfdxri93	187	51	and	and	CC
cord-288868-qfdxri93	187	52	promotes	promote	VBZ
cord-288868-qfdxri93	187	53	antibody	antibody	NN
cord-288868-qfdxri93	187	54	or	or	CC
cord-288868-qfdxri93	187	55	cytotoxic	cytotoxic	JJ
cord-288868-qfdxri93	187	56	T	t	NN
cord-288868-qfdxri93	187	57	cell	cell	NN
cord-288868-qfdxri93	187	58	responses	response	NNS
cord-288868-qfdxri93	188	1	This	this	DT
cord-288868-qfdxri93	188	2	elegant	elegant	JJ
cord-288868-qfdxri93	188	3	study	study	NN
cord-288868-qfdxri93	188	4	showed	show	VBD
cord-288868-qfdxri93	188	5	how	how	WRB
cord-288868-qfdxri93	188	6	all	all	DT
cord-288868-qfdxri93	188	7	of	of	IN
cord-288868-qfdxri93	188	8	the	the	DT
cord-288868-qfdxri93	188	9	components	component	NNS
cord-288868-qfdxri93	188	10	required	require	VBN
cord-288868-qfdxri93	188	11	for	for	IN
cord-288868-qfdxri93	188	12	an	an	DT
cord-288868-qfdxri93	188	13	efficient	efficient	JJ
cord-288868-qfdxri93	188	14	vaccine	vaccine	NN
cord-288868-qfdxri93	188	15	can	can	MD
cord-288868-qfdxri93	188	16	be	be	VB
cord-288868-qfdxri93	188	17	included	include	VBN
cord-288868-qfdxri93	188	18	in	in	IN
cord-288868-qfdxri93	188	19	one	one	CD
cord-288868-qfdxri93	188	20	synthetic	synthetic	JJ
cord-288868-qfdxri93	188	21	molecule	molecule	NN
cord-288868-qfdxri93	188	22	:	:	:
cord-288868-qfdxri93	188	23	a	a	DT
cord-288868-qfdxri93	188	24	T	T	NNP
cord-288868-qfdxri93	188	25	helper	helper	NN
cord-288868-qfdxri93	188	26	epitope	epitope	NN
cord-288868-qfdxri93	188	27	,	,	,
cord-288868-qfdxri93	188	28	a	a	DT
cord-288868-qfdxri93	188	29	TLR	TLR	NNP
cord-288868-qfdxri93	188	30	agonist	agonist	NN
cord-288868-qfdxri93	188	31	as	as	IN
cord-288868-qfdxri93	188	32	an	an	DT
cord-288868-qfdxri93	188	33	adjuvant	adjuvant	NN
cord-288868-qfdxri93	188	34	and	and	CC
cord-288868-qfdxri93	188	35	either	either	CC
cord-288868-qfdxri93	188	36	a	a	DT
cord-288868-qfdxri93	188	37	CD8	CD8	NNP
cord-288868-qfdxri93	188	38	+	+	CC
cord-288868-qfdxri93	188	39	T	T	NNP
cord-288868-qfdxri93	188	40	cell	cell	NN
cord-288868-qfdxri93	188	41	or	or	CC
cord-288868-qfdxri93	188	42	a	a	DT
cord-288868-qfdxri93	188	43	B	b	NN
cord-288868-qfdxri93	188	44	cell	cell	NN
cord-288868-qfdxri93	188	45	epitope	epitope	NN
cord-288868-qfdxri93	188	46	.	.	.
cord-288868-qfdxri93	189	1	The	the	DT
cord-288868-qfdxri93	189	2	resultant	resultant	JJ
cord-288868-qfdxri93	189	3	vaccines	vaccine	NNS
cord-288868-qfdxri93	189	4	confer	confer	VBP
cord-288868-qfdxri93	189	5	protection	protection	NN
cord-288868-qfdxri93	189	6	and	and	CC
cord-288868-qfdxri93	189	7	are	be	VBP
cord-288868-qfdxri93	189	8	able	able	JJ
cord-288868-qfdxri93	189	9	to	to	TO
cord-288868-qfdxri93	189	10	break	break	VB
cord-288868-qfdxri93	189	11	tolerance	tolerance	NN
cord-288868-qfdxri93	189	12	in	in	IN
cord-288868-qfdxri93	189	13	mice	mouse	NNS
cord-288868-qfdxri93	190	1	Variegation	variegation	NN
cord-288868-qfdxri93	190	2	of	of	IN
cord-288868-qfdxri93	190	3	the	the	DT
cord-288868-qfdxri93	190	4	immune	immune	JJ
cord-288868-qfdxri93	190	5	response	response	NN
cord-288868-qfdxri93	190	6	with	with	IN
cord-288868-qfdxri93	190	7	dendritic	dendritic	JJ
cord-288868-qfdxri93	190	8	cells	cell	NNS
cord-288868-qfdxri93	190	9	and	and	CC
cord-288868-qfdxri93	190	10	pathogen	pathogen	NN
cord-288868-qfdxri93	190	11	recognition	recognition	NN
cord-288868-qfdxri93	190	12	receptors	receptor	NNS
cord-288868-qfdxri93	190	13	Identification	identification	NN
cord-288868-qfdxri93	190	14	of	of	IN
cord-288868-qfdxri93	190	15	a	a	DT
cord-288868-qfdxri93	190	16	universal	universal	JJ
cord-288868-qfdxri93	190	17	group	group	NN
cord-288868-qfdxri93	190	18	B	B	NNP
cord-288868-qfdxri93	190	19	streptococcus	streptococcus	NN
cord-288868-qfdxri93	190	20	vaccine	vaccine	NN
cord-288868-qfdxri93	190	21	by	by	IN
cord-288868-qfdxri93	190	22	multiple	multiple	JJ
cord-288868-qfdxri93	190	23	genome	genome	NN
cord-288868-qfdxri93	190	24	screen	screen	NN
cord-288868-qfdxri93	191	1	The	the	DT
cord-288868-qfdxri93	191	2	use	use	NN
cord-288868-qfdxri93	191	3	of	of	IN
cord-288868-qfdxri93	191	4	different	different	JJ
cord-288868-qfdxri93	191	5	group	group	NN
cord-288868-qfdxri93	191	6	B	b	NN
cord-288868-qfdxri93	191	7	streptococcus	streptococcus	NN
cord-288868-qfdxri93	191	8	strains	strain	NNS
cord-288868-qfdxri93	191	9	for	for	IN
cord-288868-qfdxri93	191	10	genome	genome	NN
cord-288868-qfdxri93	191	11	analysis	analysis	NN
cord-288868-qfdxri93	191	12	and	and	CC
cord-288868-qfdxri93	191	13	screening	screening	NN
cord-288868-qfdxri93	191	14	enables	enable	VBZ
cord-288868-qfdxri93	191	15	the	the	DT
cord-288868-qfdxri93	191	16	development	development	NN
cord-288868-qfdxri93	191	17	of	of	IN
cord-288868-qfdxri93	191	18	a	a	DT
cord-288868-qfdxri93	191	19	universal	universal	JJ
cord-288868-qfdxri93	191	20	vaccine	vaccine	NN
cord-288868-qfdxri93	191	21	.	.	.
cord-288868-qfdxri93	192	1	The	the	DT
cord-288868-qfdxri93	192	2	single	single	JJ
cord-288868-qfdxri93	192	3	vaccine	vaccine	NN
cord-288868-qfdxri93	192	4	components	component	NNS
cord-288868-qfdxri93	192	5	are	be	VBP
cord-288868-qfdxri93	192	6	not	not	RB
cord-288868-qfdxri93	192	7	present	present	JJ
cord-288868-qfdxri93	192	8	in	in	IN
cord-288868-qfdxri93	192	9	all	all	DT
cord-288868-qfdxri93	192	10	strains	strain	NNS
cord-288868-qfdxri93	192	11	,	,	,
cord-288868-qfdxri93	192	12	and	and	CC
cord-288868-qfdxri93	192	13	do	do	VBP
cord-288868-qfdxri93	192	14	not	not	RB
cord-288868-qfdxri93	192	15	protect	protect	VB
cord-288868-qfdxri93	192	16	against	against	IN
cord-288868-qfdxri93	192	17	all	all	DT
cord-288868-qfdxri93	192	18	strains	strain	NNS
cord-288868-qfdxri93	192	19	We	-PRON-	PRP
cord-288868-qfdxri93	192	20	are	be	VBP
cord-288868-qfdxri93	192	21	grateful	grateful	JJ
cord-288868-qfdxri93	192	22	to	to	IN
cord-288868-qfdxri93	192	23	Giorgio	Giorgio	NNP
cord-288868-qfdxri93	192	24	Corsi	Corsi	NNP
cord-288868-qfdxri93	192	25	for	for	IN
cord-288868-qfdxri93	192	26	artwork	artwork	NN
cord-288868-qfdxri93	192	27	.	.	.
cord-288868-qfdxri93	193	1	Papers	paper	NNS
cord-288868-qfdxri93	193	2	of	of	IN
cord-288868-qfdxri93	193	3	particular	particular	JJ
cord-288868-qfdxri93	193	4	interest	interest	NN
cord-288868-qfdxri93	193	5	,	,	,
cord-288868-qfdxri93	193	6	published	publish	VBN
cord-288868-qfdxri93	193	7	within	within	IN
cord-288868-qfdxri93	193	8	the	the	DT
cord-288868-qfdxri93	193	9	annual	annual	JJ
cord-288868-qfdxri93	193	10	period	period	NN
cord-288868-qfdxri93	193	11	of	of	IN
cord-288868-qfdxri93	193	12	review	review	NN
cord-288868-qfdxri93	193	13	,	,	,
cord-288868-qfdxri93	193	14	have	have	VBP
cord-288868-qfdxri93	193	15	been	be	VBN
cord-288868-qfdxri93	193	16	highlighted	highlight	VBN
cord-288868-qfdxri93	193	17	as	as	IN
cord-288868-qfdxri93	193	18	:	:	:
cord-288868-qfdxri93	193	19	of	of	IN
cord-288868-qfdxri93	193	20	special	special	JJ
cord-288868-qfdxri93	193	21	interest	interest	NN
cord-288868-qfdxri93	193	22	of	of	IN
cord-288868-qfdxri93	193	23	outstanding	outstanding	JJ
cord-288868-qfdxri93	193	24	interest	interest	NN