id	sid	tid	token	lemma	pos
cord-270469-lle32mha	1	1	key	key	JJ
cord-270469-lle32mha	2	1	:	:	:
cord-270469-lle32mha	2	2	cord-270469-lle32mha	cord-270469-lle32mha	NN
cord-270469-lle32mha	2	3	authors	author	NNS
cord-270469-lle32mha	2	4	:	:	:
cord-270469-lle32mha	3	1	Martinon	Martinon	NNP
cord-270469-lle32mha	3	2	,	,	,
cord-270469-lle32mha	3	3	Fabio	Fabio	NNP
cord-270469-lle32mha	3	4	title	title	NN
cord-270469-lle32mha	3	5	:	:	:
cord-270469-lle32mha	3	6	The	the	DT
cord-270469-lle32mha	3	7	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	3	8	reticulum	reticulum	NN
cord-270469-lle32mha	3	9	:	:	:
cord-270469-lle32mha	3	10	a	a	DT
cord-270469-lle32mha	3	11	sensor	sensor	NN
cord-270469-lle32mha	3	12	of	of	IN
cord-270469-lle32mha	3	13	cellular	cellular	JJ
cord-270469-lle32mha	3	14	stress	stress	NN
cord-270469-lle32mha	3	15	that	that	WDT
cord-270469-lle32mha	3	16	modulates	modulate	VBZ
cord-270469-lle32mha	3	17	immune	immune	JJ
cord-270469-lle32mha	3	18	responses	response	NNS
cord-270469-lle32mha	3	19	date	date	NN
cord-270469-lle32mha	3	20	:	:	:
cord-270469-lle32mha	3	21	2012	2012	CD
cord-270469-lle32mha	3	22	-	-	HYPH
cord-270469-lle32mha	3	23	07	07	CD
cord-270469-lle32mha	3	24	-	-	SYM
cord-270469-lle32mha	3	25	15	15	CD
cord-270469-lle32mha	3	26	journal	journal	NN
cord-270469-lle32mha	3	27	:	:	:
cord-270469-lle32mha	4	1	Microbes	microbe	NNS
cord-270469-lle32mha	4	2	Infect	infect	VBP
cord-270469-lle32mha	4	3	DOI	doi	NN
cord-270469-lle32mha	4	4	:	:	:
cord-270469-lle32mha	4	5	10.1016/	10.1016/	CD
cord-270469-lle32mha	5	1	j.micinf.2012.07.005	j.micinf.2012.07.005	NNP
cord-270469-lle32mha	5	2	sha	sha	NN
cord-270469-lle32mha	5	3	:	:	:
cord-270469-lle32mha	6	1	e0a60615d19df1b55b1d237cb57ad01f9ac9be04	e0a60615d19df1b55b1d237cb57ad01f9ac9be04	NN
cord-270469-lle32mha	7	1	doc_id	doc_id	CD
cord-270469-lle32mha	8	1	:	:	:
cord-270469-lle32mha	8	2	270469	270469	CD
cord-270469-lle32mha	8	3	cord_uid	cord_uid	NNS
cord-270469-lle32mha	8	4	:	:	:
cord-270469-lle32mha	9	1	lle32mha	lle32mha	NFP
cord-270469-lle32mha	9	2	Many	many	JJ
cord-270469-lle32mha	9	3	inflammatory	inflammatory	JJ
cord-270469-lle32mha	9	4	and	and	CC
cord-270469-lle32mha	9	5	infectious	infectious	JJ
cord-270469-lle32mha	9	6	diseases	disease	NNS
cord-270469-lle32mha	9	7	are	be	VBP
cord-270469-lle32mha	9	8	characterized	characterize	VBN
cord-270469-lle32mha	9	9	by	by	IN
cord-270469-lle32mha	9	10	the	the	DT
cord-270469-lle32mha	9	11	activation	activation	NN
cord-270469-lle32mha	9	12	of	of	IN
cord-270469-lle32mha	9	13	signaling	signal	VBG
cord-270469-lle32mha	9	14	pathways	pathway	NNS
cord-270469-lle32mha	9	15	steaming	steam	VBG
cord-270469-lle32mha	9	16	from	from	IN
cord-270469-lle32mha	9	17	the	the	DT
cord-270469-lle32mha	9	18	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	9	19	reticulum	reticulum	NN
cord-270469-lle32mha	9	20	(	(	-LRB-
cord-270469-lle32mha	9	21	ER	ER	NNP
cord-270469-lle32mha	9	22	)	)	-RRB-
cord-270469-lle32mha	9	23	.	.	.
cord-270469-lle32mha	10	1	These	these	DT
cord-270469-lle32mha	10	2	pathways	pathway	NNS
cord-270469-lle32mha	10	3	,	,	,
cord-270469-lle32mha	10	4	primarily	primarily	RB
cord-270469-lle32mha	10	5	associated	associate	VBN
cord-270469-lle32mha	10	6	with	with	IN
cord-270469-lle32mha	10	7	loss	loss	NN
cord-270469-lle32mha	10	8	of	of	IN
cord-270469-lle32mha	10	9	ER	ER	NNP
cord-270469-lle32mha	10	10	homeostasis	homeostasis	NN
cord-270469-lle32mha	10	11	,	,	,
cord-270469-lle32mha	10	12	are	be	VBP
cord-270469-lle32mha	10	13	emerging	emerge	VBG
cord-270469-lle32mha	10	14	as	as	IN
cord-270469-lle32mha	10	15	key	key	JJ
cord-270469-lle32mha	10	16	regulators	regulator	NNS
cord-270469-lle32mha	10	17	of	of	IN
cord-270469-lle32mha	10	18	inflammation	inflammation	NN
cord-270469-lle32mha	10	19	and	and	CC
cord-270469-lle32mha	10	20	infection	infection	NN
cord-270469-lle32mha	10	21	.	.	.
cord-270469-lle32mha	11	1	Recent	recent	JJ
cord-270469-lle32mha	11	2	advances	advance	NNS
cord-270469-lle32mha	11	3	shed	shed	VBP
cord-270469-lle32mha	11	4	light	light	NN
cord-270469-lle32mha	11	5	on	on	IN
cord-270469-lle32mha	11	6	the	the	DT
cord-270469-lle32mha	11	7	mechanisms	mechanism	NNS
cord-270469-lle32mha	11	8	linking	link	VBG
cord-270469-lle32mha	11	9	ER	er	NN
cord-270469-lle32mha	11	10	-	-	HYPH
cord-270469-lle32mha	11	11	stress	stress	NN
cord-270469-lle32mha	11	12	and	and	CC
cord-270469-lle32mha	11	13	immune	immune	JJ
cord-270469-lle32mha	11	14	responses	response	NNS
cord-270469-lle32mha	11	15	.	.	.
cord-270469-lle32mha	12	1	Loss	loss	NN
cord-270469-lle32mha	12	2	of	of	IN
cord-270469-lle32mha	12	3	cellular	cellular	JJ
cord-270469-lle32mha	12	4	integrity	integrity	NN
cord-270469-lle32mha	12	5	is	be	VBZ
cord-270469-lle32mha	12	6	a	a	DT
cord-270469-lle32mha	12	7	hallmark	hallmark	NN
cord-270469-lle32mha	12	8	of	of	IN
cord-270469-lle32mha	12	9	severe	severe	JJ
cord-270469-lle32mha	12	10	pathogenic	pathogenic	JJ
cord-270469-lle32mha	12	11	insults	insult	NNS
cord-270469-lle32mha	12	12	and	and	CC
cord-270469-lle32mha	12	13	leads	lead	VBZ
cord-270469-lle32mha	12	14	to	to	IN
cord-270469-lle32mha	12	15	the	the	DT
cord-270469-lle32mha	12	16	activation	activation	NN
cord-270469-lle32mha	12	17	of	of	IN
cord-270469-lle32mha	12	18	immune	immune	JJ
cord-270469-lle32mha	12	19	defenses	defense	NNS
cord-270469-lle32mha	12	20	aimed	aim	VBN
cord-270469-lle32mha	12	21	at	at	IN
cord-270469-lle32mha	12	22	repairing	repair	VBG
cord-270469-lle32mha	12	23	tissue	tissue	NN
cord-270469-lle32mha	12	24	damage	damage	NN
cord-270469-lle32mha	12	25	and	and	CC
cord-270469-lle32mha	12	26	fighting	fighting	NN
cord-270469-lle32mha	12	27	infections	infection	NNS
cord-270469-lle32mha	12	28	.	.	.
cord-270469-lle32mha	13	1	It	-PRON-	PRP
cord-270469-lle32mha	13	2	has	have	VBZ
cord-270469-lle32mha	13	3	been	be	VBN
cord-270469-lle32mha	13	4	postulated	postulate	VBN
cord-270469-lle32mha	13	5	that	that	IN
cord-270469-lle32mha	13	6	the	the	DT
cord-270469-lle32mha	13	7	release	release	NN
cord-270469-lle32mha	13	8	of	of	IN
cord-270469-lle32mha	13	9	danger	danger	NN
cord-270469-lle32mha	13	10	signals	signal	NNS
cord-270469-lle32mha	13	11	by	by	IN
cord-270469-lle32mha	13	12	damaged	damage	VBN
cord-270469-lle32mha	13	13	cells	cell	NNS
cord-270469-lle32mha	13	14	could	could	MD
cord-270469-lle32mha	13	15	lead	lead	VB
cord-270469-lle32mha	13	16	to	to	IN
cord-270469-lle32mha	13	17	the	the	DT
cord-270469-lle32mha	13	18	mounting	mounting	NN
cord-270469-lle32mha	13	19	of	of	IN
cord-270469-lle32mha	13	20	immune	immune	JJ
cord-270469-lle32mha	13	21	defenses	defense	NNS
cord-270469-lle32mha	13	22	[	[	-LRB-
cord-270469-lle32mha	13	23	1e3	1e3	CD
cord-270469-lle32mha	13	24	]	]	-RRB-
cord-270469-lle32mha	13	25	.	.	.
cord-270469-lle32mha	14	1	These	these	DT
cord-270469-lle32mha	14	2	danger	danger	NN
cord-270469-lle32mha	14	3	signals	signal	NNS
cord-270469-lle32mha	14	4	also	also	RB
cord-270469-lle32mha	14	5	known	know	VBN
cord-270469-lle32mha	14	6	as	as	IN
cord-270469-lle32mha	14	7	damage	damage	NN
cord-270469-lle32mha	14	8	associated	associate	VBD
cord-270469-lle32mha	14	9	molecular	molecular	JJ
cord-270469-lle32mha	14	10	pattern	pattern	NN
cord-270469-lle32mha	14	11	(	(	-LRB-
cord-270469-lle32mha	14	12	DAMPs	damp	NNS
cord-270469-lle32mha	14	13	)	)	-RRB-
cord-270469-lle32mha	14	14	are	be	VBP
cord-270469-lle32mha	14	15	molecules	molecule	NNS
cord-270469-lle32mha	14	16	that	that	WDT
cord-270469-lle32mha	14	17	trigger	trigger	VBP
cord-270469-lle32mha	14	18	specific	specific	JJ
cord-270469-lle32mha	14	19	receptors	receptor	NNS
cord-270469-lle32mha	14	20	including	include	VBG
cord-270469-lle32mha	14	21	receptors	receptor	NNS
cord-270469-lle32mha	14	22	that	that	WDT
cord-270469-lle32mha	14	23	initiate	initiate	VBP
cord-270469-lle32mha	14	24	inflammatory	inflammatory	JJ
cord-270469-lle32mha	14	25	and	and	CC
cord-270469-lle32mha	14	26	immune	immune	JJ
cord-270469-lle32mha	14	27	responses	response	NNS
cord-270469-lle32mha	14	28	.	.	.
cord-270469-lle32mha	15	1	Many	many	JJ
cord-270469-lle32mha	15	2	DAMPs	damp	NNS
cord-270469-lle32mha	15	3	are	be	VBP
cord-270469-lle32mha	15	4	nuclear	nuclear	JJ
cord-270469-lle32mha	15	5	proteins	protein	NNS
cord-270469-lle32mha	15	6	such	such	JJ
cord-270469-lle32mha	15	7	as	as	IN
cord-270469-lle32mha	15	8	HMGB1	HMGB1	NNP
cord-270469-lle32mha	15	9	or	or	CC
cord-270469-lle32mha	15	10	cytosolic	cytosolic	JJ
cord-270469-lle32mha	15	11	molecules	molecule	NNS
cord-270469-lle32mha	15	12	including	include	VBG
cord-270469-lle32mha	15	13	,	,	,
cord-270469-lle32mha	15	14	for	for	IN
cord-270469-lle32mha	15	15	example	example	NN
cord-270469-lle32mha	15	16	,	,	,
cord-270469-lle32mha	15	17	uric	uric	NN
cord-270469-lle32mha	15	18	acid	acid	NN
cord-270469-lle32mha	15	19	and	and	CC
cord-270469-lle32mha	15	20	ATP	ATP	NNP
cord-270469-lle32mha	15	21	.	.	.
cord-270469-lle32mha	16	1	When	when	WRB
cord-270469-lle32mha	16	2	released	release	VBN
cord-270469-lle32mha	16	3	outside	outside	RB
cord-270469-lle32mha	16	4	of	of	IN
cord-270469-lle32mha	16	5	the	the	DT
cord-270469-lle32mha	16	6	cell	cell	NN
cord-270469-lle32mha	16	7	following	follow	VBG
cord-270469-lle32mha	16	8	tissue	tissue	NN
cord-270469-lle32mha	16	9	injury	injury	NN
cord-270469-lle32mha	16	10	,	,	,
cord-270469-lle32mha	16	11	DAMPs	damp	NNS
cord-270469-lle32mha	16	12	are	be	VBP
cord-270469-lle32mha	16	13	sensed	sense	VBN
cord-270469-lle32mha	16	14	by	by	IN
cord-270469-lle32mha	16	15	immune	immune	JJ
cord-270469-lle32mha	16	16	cells	cell	NNS
cord-270469-lle32mha	16	17	and	and	CC
cord-270469-lle32mha	16	18	trigger	trigger	VB
cord-270469-lle32mha	16	19	innate	innate	JJ
cord-270469-lle32mha	16	20	immune	immune	JJ
cord-270469-lle32mha	16	21	receptors	receptor	NNS
cord-270469-lle32mha	16	22	such	such	JJ
cord-270469-lle32mha	16	23	as	as	IN
cord-270469-lle32mha	16	24	the	the	DT
cord-270469-lle32mha	16	25	Toll	Toll	NNP
cord-270469-lle32mha	16	26	-	-	HYPH
cord-270469-lle32mha	16	27	like	like	JJ
cord-270469-lle32mha	16	28	receptors	receptor	NNS
cord-270469-lle32mha	16	29	(	(	-LRB-
cord-270469-lle32mha	16	30	TLRs	TLRs	NNP
cord-270469-lle32mha	16	31	)	)	-RRB-
cord-270469-lle32mha	16	32	or	or	CC
cord-270469-lle32mha	16	33	the	the	DT
cord-270469-lle32mha	16	34	NLRP3	nlrp3	XX
cord-270469-lle32mha	16	35	inflammasome	inflammasome	NNP
cord-270469-lle32mha	16	36	[	[	-LRB-
cord-270469-lle32mha	16	37	4	4	CD
cord-270469-lle32mha	16	38	,	,	,
cord-270469-lle32mha	16	39	5	5	CD
cord-270469-lle32mha	16	40	]	]	-RRB-
cord-270469-lle32mha	16	41	.	.	.
cord-270469-lle32mha	17	1	The	the	DT
cord-270469-lle32mha	17	2	release	release	NN
cord-270469-lle32mha	17	3	of	of	IN
cord-270469-lle32mha	17	4	DAMPs	damp	NNS
cord-270469-lle32mha	17	5	by	by	IN
cord-270469-lle32mha	17	6	cells	cell	NNS
cord-270469-lle32mha	17	7	is	be	VBZ
cord-270469-lle32mha	17	8	often	often	RB
cord-270469-lle32mha	17	9	described	describe	VBN
cord-270469-lle32mha	17	10	as	as	IN
cord-270469-lle32mha	17	11	a	a	DT
cord-270469-lle32mha	17	12	passive	passive	JJ
cord-270469-lle32mha	17	13	process	process	NN
cord-270469-lle32mha	17	14	,	,	,
cord-270469-lle32mha	17	15	occurring	occur	VBG
cord-270469-lle32mha	17	16	as	as	IN
cord-270469-lle32mha	17	17	a	a	DT
cord-270469-lle32mha	17	18	consequence	consequence	NN
cord-270469-lle32mha	17	19	of	of	IN
cord-270469-lle32mha	17	20	sustained	sustained	JJ
cord-270469-lle32mha	17	21	cell	cell	NN
cord-270469-lle32mha	17	22	damage	damage	NN
cord-270469-lle32mha	17	23	.	.	.
cord-270469-lle32mha	18	1	This	this	DT
cord-270469-lle32mha	18	2	process	process	NN
cord-270469-lle32mha	18	3	is	be	VBZ
cord-270469-lle32mha	18	4	irreversible	irreversible	JJ
cord-270469-lle32mha	18	5	and	and	CC
cord-270469-lle32mha	18	6	correlates	correlate	VBZ
cord-270469-lle32mha	18	7	with	with	IN
cord-270469-lle32mha	18	8	the	the	DT
cord-270469-lle32mha	18	9	death	death	NN
cord-270469-lle32mha	18	10	and	and	CC
cord-270469-lle32mha	18	11	elimination	elimination	NN
cord-270469-lle32mha	18	12	of	of	IN
cord-270469-lle32mha	18	13	the	the	DT
cord-270469-lle32mha	18	14	damaged	damage	VBN
cord-270469-lle32mha	18	15	cell	cell	NN
cord-270469-lle32mha	18	16	.	.	.
cord-270469-lle32mha	19	1	However	however	RB
cord-270469-lle32mha	19	2	,	,	,
cord-270469-lle32mha	19	3	before	before	IN
cord-270469-lle32mha	19	4	losing	lose	VBG
cord-270469-lle32mha	19	5	membrane	membrane	NN
cord-270469-lle32mha	19	6	integrity	integrity	NN
cord-270469-lle32mha	19	7	,	,	,
cord-270469-lle32mha	19	8	cells	cell	NNS
cord-270469-lle32mha	19	9	can	can	MD
cord-270469-lle32mha	19	10	experience	experience	VB
cord-270469-lle32mha	19	11	various	various	JJ
cord-270469-lle32mha	19	12	states	state	NNS
cord-270469-lle32mha	19	13	of	of	IN
cord-270469-lle32mha	19	14	malfunction	malfunction	NN
cord-270469-lle32mha	19	15	that	that	WDT
cord-270469-lle32mha	19	16	are	be	VBP
cord-270469-lle32mha	19	17	reversible	reversible	JJ
cord-270469-lle32mha	19	18	.	.	.
cord-270469-lle32mha	20	1	We	-PRON-	PRP
cord-270469-lle32mha	20	2	can	can	MD
cord-270469-lle32mha	20	3	define	define	VB
cord-270469-lle32mha	20	4	these	these	DT
cord-270469-lle32mha	20	5	cellular	cellular	JJ
cord-270469-lle32mha	20	6	states	state	NNS
cord-270469-lle32mha	20	7	as	as	IN
cord-270469-lle32mha	20	8	stress	stress	NN
cord-270469-lle32mha	20	9	.	.	.
cord-270469-lle32mha	21	1	Typically	typically	RB
cord-270469-lle32mha	21	2	,	,	,
cord-270469-lle32mha	21	3	stressed	stress	VBN
cord-270469-lle32mha	21	4	cells	cell	NNS
cord-270469-lle32mha	21	5	are	be	VBP
cord-270469-lle32mha	21	6	malfunctioning	malfunction	VBG
cord-270469-lle32mha	21	7	,	,	,
cord-270469-lle32mha	21	8	but	but	CC
cord-270469-lle32mha	21	9	are	be	VBP
cord-270469-lle32mha	21	10	also	also	RB
cord-270469-lle32mha	21	11	characterized	characterize	VBN
cord-270469-lle32mha	21	12	by	by	IN
cord-270469-lle32mha	21	13	the	the	DT
cord-270469-lle32mha	21	14	activation	activation	NN
cord-270469-lle32mha	21	15	of	of	IN
cord-270469-lle32mha	21	16	adaptation	adaptation	NN
cord-270469-lle32mha	21	17	responses	response	NNS
cord-270469-lle32mha	21	18	to	to	IN
cord-270469-lle32mha	21	19	the	the	DT
cord-270469-lle32mha	21	20	stress	stress	NN
cord-270469-lle32mha	21	21	aimed	aim	VBN
cord-270469-lle32mha	21	22	at	at	IN
cord-270469-lle32mha	21	23	repairing	repair	VBG
cord-270469-lle32mha	21	24	cell	cell	NN
cord-270469-lle32mha	21	25	damage	damage	NN
cord-270469-lle32mha	21	26	.	.	.
cord-270469-lle32mha	22	1	Stress	stress	NN
cord-270469-lle32mha	22	2	can	can	MD
cord-270469-lle32mha	22	3	be	be	VB
cord-270469-lle32mha	22	4	a	a	DT
cord-270469-lle32mha	22	5	consequence	consequence	NN
cord-270469-lle32mha	22	6	of	of	IN
cord-270469-lle32mha	22	7	perturbations	perturbation	NNS
cord-270469-lle32mha	22	8	in	in	IN
cord-270469-lle32mha	22	9	basic	basic	JJ
cord-270469-lle32mha	22	10	cellular	cellular	JJ
cord-270469-lle32mha	22	11	functions	function	NNS
cord-270469-lle32mha	22	12	including	include	VBG
cord-270469-lle32mha	22	13	the	the	DT
cord-270469-lle32mha	22	14	availability	availability	NN
cord-270469-lle32mha	22	15	of	of	IN
cord-270469-lle32mha	22	16	nutrients	nutrient	NNS
cord-270469-lle32mha	22	17	and	and	CC
cord-270469-lle32mha	22	18	oxygen	oxygen	NN
cord-270469-lle32mha	22	19	as	as	RB
cord-270469-lle32mha	22	20	well	well	RB
cord-270469-lle32mha	22	21	as	as	IN
cord-270469-lle32mha	22	22	the	the	DT
cord-270469-lle32mha	22	23	capacity	capacity	NN
cord-270469-lle32mha	22	24	to	to	TO
cord-270469-lle32mha	22	25	communicate	communicate	VB
cord-270469-lle32mha	22	26	with	with	IN
cord-270469-lle32mha	22	27	neighboring	neighboring	NN
cord-270469-lle32mha	22	28	cells	cell	NNS
cord-270469-lle32mha	22	29	and	and	CC
cord-270469-lle32mha	22	30	to	to	TO
cord-270469-lle32mha	22	31	respond	respond	VB
cord-270469-lle32mha	22	32	to	to	IN
cord-270469-lle32mha	22	33	changes	change	NNS
cord-270469-lle32mha	22	34	in	in	IN
cord-270469-lle32mha	22	35	the	the	DT
cord-270469-lle32mha	22	36	microenvironment	microenvironment	NN
cord-270469-lle32mha	22	37	.	.	.
cord-270469-lle32mha	23	1	If	if	IN
cord-270469-lle32mha	23	2	the	the	DT
cord-270469-lle32mha	23	3	cell	cell	NN
cord-270469-lle32mha	23	4	is	be	VBZ
cord-270469-lle32mha	23	5	able	able	JJ
cord-270469-lle32mha	23	6	to	to	TO
cord-270469-lle32mha	23	7	sense	sense	VB
cord-270469-lle32mha	23	8	these	these	DT
cord-270469-lle32mha	23	9	perturbations	perturbation	NNS
cord-270469-lle32mha	23	10	it	-PRON-	PRP
cord-270469-lle32mha	23	11	mounts	mount	VBZ
cord-270469-lle32mha	23	12	a	a	DT
cord-270469-lle32mha	23	13	response	response	NN
cord-270469-lle32mha	23	14	(	(	-LRB-
cord-270469-lle32mha	23	15	hereby	hereby	RB
cord-270469-lle32mha	23	16	referred	refer	VBD
cord-270469-lle32mha	23	17	to	to	IN
cord-270469-lle32mha	23	18	as	as	IN
cord-270469-lle32mha	23	19	a	a	DT
cord-270469-lle32mha	23	20	stress	stress	NN
cord-270469-lle32mha	23	21	response	response	NN
cord-270469-lle32mha	23	22	)	)	-RRB-
cord-270469-lle32mha	23	23	that	that	IN
cord-270469-lle32mha	23	24	,	,	,
cord-270469-lle32mha	23	25	by	by	IN
cord-270469-lle32mha	23	26	definition	definition	NN
cord-270469-lle32mha	23	27	,	,	,
cord-270469-lle32mha	23	28	is	be	VBZ
cord-270469-lle32mha	23	29	an	an	DT
cord-270469-lle32mha	23	30	active	active	JJ
cord-270469-lle32mha	23	31	cellular	cellular	JJ
cord-270469-lle32mha	23	32	adaptation	adaptation	NN
cord-270469-lle32mha	23	33	to	to	IN
cord-270469-lle32mha	23	34	the	the	DT
cord-270469-lle32mha	23	35	abnormal	abnormal	JJ
cord-270469-lle32mha	23	36	conditions	condition	NNS
cord-270469-lle32mha	23	37	.	.	.
cord-270469-lle32mha	24	1	If	if	IN
cord-270469-lle32mha	24	2	this	this	DT
cord-270469-lle32mha	24	3	repair	repair	NN
cord-270469-lle32mha	24	4	/	/	SYM
cord-270469-lle32mha	24	5	adaptation	adaptation	NN
cord-270469-lle32mha	24	6	fail	fail	VBP
cord-270469-lle32mha	24	7	or	or	CC
cord-270469-lle32mha	24	8	if	if	IN
cord-270469-lle32mha	24	9	the	the	DT
cord-270469-lle32mha	24	10	stress	stress	NN
cord-270469-lle32mha	24	11	is	be	VBZ
cord-270469-lle32mha	24	12	too	too	RB
cord-270469-lle32mha	24	13	severe	severe	JJ
cord-270469-lle32mha	24	14	,	,	,
cord-270469-lle32mha	24	15	the	the	DT
cord-270469-lle32mha	24	16	cell	cell	NN
cord-270469-lle32mha	24	17	will	will	MD
cord-270469-lle32mha	24	18	eventually	eventually	RB
cord-270469-lle32mha	24	19	die	die	VB
cord-270469-lle32mha	24	20	possibly	possibly	RB
cord-270469-lle32mha	24	21	releasing	release	VBG
cord-270469-lle32mha	24	22	DAMPs	damp	NNS
cord-270469-lle32mha	24	23	.	.	.
cord-270469-lle32mha	25	1	Tissue	tissue	NN
cord-270469-lle32mha	25	2	stress	stress	NN
cord-270469-lle32mha	25	3	and	and	CC
cord-270469-lle32mha	25	4	malfunction	malfunction	NN
cord-270469-lle32mha	25	5	promotes	promote	VBZ
cord-270469-lle32mha	25	6	low	low	JJ
cord-270469-lle32mha	25	7	-	-	HYPH
cord-270469-lle32mha	25	8	grade	grade	NN
cord-270469-lle32mha	25	9	inflammation	inflammation	NN
cord-270469-lle32mha	25	10	which	which	WDT
cord-270469-lle32mha	25	11	helps	help	VBZ
cord-270469-lle32mha	25	12	the	the	DT
cord-270469-lle32mha	25	13	tissue	tissue	NN
cord-270469-lle32mha	25	14	to	to	TO
cord-270469-lle32mha	25	15	adapt	adapt	VB
cord-270469-lle32mha	25	16	to	to	IN
cord-270469-lle32mha	25	17	the	the	DT
cord-270469-lle32mha	25	18	damage	damage	NN
cord-270469-lle32mha	25	19	and	and	CC
cord-270469-lle32mha	25	20	restore	restore	VB
cord-270469-lle32mha	25	21	tissue	tissue	NN
cord-270469-lle32mha	25	22	function	function	NN
cord-270469-lle32mha	25	23	[	[	-LRB-
cord-270469-lle32mha	25	24	6	6	CD
cord-270469-lle32mha	25	25	,	,	,
cord-270469-lle32mha	25	26	7	7	CD
cord-270469-lle32mha	25	27	]	]	-RRB-
cord-270469-lle32mha	25	28	.	.	.
cord-270469-lle32mha	26	1	This	this	DT
cord-270469-lle32mha	26	2	low	low	JJ
cord-270469-lle32mha	26	3	-	-	HYPH
cord-270469-lle32mha	26	4	grade	grade	NN
cord-270469-lle32mha	26	5	inflammation	inflammation	NN
cord-270469-lle32mha	26	6	also	also	RB
cord-270469-lle32mha	26	7	termed	term	VBD
cord-270469-lle32mha	26	8	para	para	NN
cord-270469-lle32mha	26	9	-	-	HYPH
cord-270469-lle32mha	26	10	inflammation	inflammation	NN
cord-270469-lle32mha	26	11	illustrates	illustrate	VBZ
cord-270469-lle32mha	26	12	how	how	WRB
cord-270469-lle32mha	26	13	stress	stress	NN
cord-270469-lle32mha	26	14	and	and	CC
cord-270469-lle32mha	26	15	possibly	possibly	RB
cord-270469-lle32mha	26	16	stress	stress	VB
cord-270469-lle32mha	26	17	response	response	NN
cord-270469-lle32mha	26	18	pathways	pathway	NNS
cord-270469-lle32mha	26	19	can	can	MD
cord-270469-lle32mha	26	20	contribute	contribute	VB
cord-270469-lle32mha	26	21	to	to	IN
cord-270469-lle32mha	26	22	immune	immune	JJ
cord-270469-lle32mha	26	23	responses	response	NNS
cord-270469-lle32mha	26	24	(	(	-LRB-
cord-270469-lle32mha	26	25	Fig	Fig	NNP
cord-270469-lle32mha	26	26	.	.	NNP
cord-270469-lle32mha	26	27	1	1	CD
cord-270469-lle32mha	26	28	)	)	-RRB-
cord-270469-lle32mha	26	29	.	.	.
cord-270469-lle32mha	27	1	However	however	RB
cord-270469-lle32mha	27	2	the	the	DT
cord-270469-lle32mha	27	3	mechanisms	mechanism	NNS
cord-270469-lle32mha	27	4	and	and	CC
cord-270469-lle32mha	27	5	the	the	DT
cord-270469-lle32mha	27	6	role	role	NN
cord-270469-lle32mha	27	7	of	of	IN
cord-270469-lle32mha	27	8	stress	stress	NN
cord-270469-lle32mha	27	9	responses	response	NNS
cord-270469-lle32mha	27	10	in	in	IN
cord-270469-lle32mha	27	11	controlling	control	VBG
cord-270469-lle32mha	27	12	innate	innate	JJ
cord-270469-lle32mha	27	13	immunity	immunity	NN
cord-270469-lle32mha	27	14	and	and	CC
cord-270469-lle32mha	27	15	inflammatory	inflammatory	JJ
cord-270469-lle32mha	27	16	pathways	pathway	NNS
cord-270469-lle32mha	27	17	are	be	VBP
cord-270469-lle32mha	27	18	poorly	poorly	RB
cord-270469-lle32mha	27	19	understood	understand	VBN
cord-270469-lle32mha	27	20	.	.	.
cord-270469-lle32mha	28	1	The	the	DT
cord-270469-lle32mha	28	2	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	28	3	reticulum	reticulum	NN
cord-270469-lle32mha	28	4	(	(	-LRB-
cord-270469-lle32mha	28	5	ER	ER	NNP
cord-270469-lle32mha	28	6	)	)	-RRB-
cord-270469-lle32mha	28	7	is	be	VBZ
cord-270469-lle32mha	28	8	emerging	emerge	VBG
cord-270469-lle32mha	28	9	as	as	IN
cord-270469-lle32mha	28	10	a	a	DT
cord-270469-lle32mha	28	11	key	key	JJ
cord-270469-lle32mha	28	12	organelle	organelle	NN
cord-270469-lle32mha	28	13	that	that	WDT
cord-270469-lle32mha	28	14	maintains	maintain	VBZ
cord-270469-lle32mha	28	15	cellular	cellular	JJ
cord-270469-lle32mha	28	16	homeostasis	homeostasis	NN
cord-270469-lle32mha	28	17	and	and	CC
cord-270469-lle32mha	28	18	contributes	contribute	VBZ
cord-270469-lle32mha	28	19	to	to	IN
cord-270469-lle32mha	28	20	the	the	DT
cord-270469-lle32mha	28	21	regulation	regulation	NN
cord-270469-lle32mha	28	22	of	of	IN
cord-270469-lle32mha	28	23	innate	innate	JJ
cord-270469-lle32mha	28	24	immune	immune	JJ
cord-270469-lle32mha	28	25	response	response	NN
cord-270469-lle32mha	28	26	[	[	-LRB-
cord-270469-lle32mha	28	27	1	1	CD
cord-270469-lle32mha	28	28	,	,	,
cord-270469-lle32mha	28	29	8	8	CD
cord-270469-lle32mha	28	30	,	,	,
cord-270469-lle32mha	28	31	9	9	CD
cord-270469-lle32mha	28	32	]	]	-RRB-
cord-270469-lle32mha	28	33	.	.	.
cord-270469-lle32mha	29	1	Perturbations	perturbation	NNS
cord-270469-lle32mha	29	2	that	that	WDT
cord-270469-lle32mha	29	3	affect	affect	VBP
cord-270469-lle32mha	29	4	the	the	DT
cord-270469-lle32mha	29	5	ER	ER	NNP
cord-270469-lle32mha	29	6	trigger	trigger	VB
cord-270469-lle32mha	29	7	a	a	DT
cord-270469-lle32mha	29	8	specific	specific	JJ
cord-270469-lle32mha	29	9	response	response	NN
cord-270469-lle32mha	29	10	known	know	VBN
cord-270469-lle32mha	29	11	as	as	IN
cord-270469-lle32mha	29	12	the	the	DT
cord-270469-lle32mha	29	13	ER	er	NN
cord-270469-lle32mha	29	14	-	-	HYPH
cord-270469-lle32mha	29	15	stress	stress	NN
cord-270469-lle32mha	29	16	response	response	NN
cord-270469-lle32mha	29	17	.	.	.
cord-270469-lle32mha	30	1	In	in	IN
cord-270469-lle32mha	30	2	this	this	DT
cord-270469-lle32mha	30	3	review	review	NN
cord-270469-lle32mha	30	4	we	-PRON-	PRP
cord-270469-lle32mha	30	5	discuss	discuss	VBP
cord-270469-lle32mha	30	6	how	how	WRB
cord-270469-lle32mha	30	7	infectious	infectious	JJ
cord-270469-lle32mha	30	8	and	and	CC
cord-270469-lle32mha	30	9	inflammatory	inflammatory	JJ
cord-270469-lle32mha	30	10	signals	signal	NNS
cord-270469-lle32mha	30	11	affect	affect	VBP
cord-270469-lle32mha	30	12	the	the	DT
cord-270469-lle32mha	30	13	ER	er	NN
cord-270469-lle32mha	30	14	and	and	CC
cord-270469-lle32mha	30	15	focus	focus	VB
cord-270469-lle32mha	30	16	on	on	IN
cord-270469-lle32mha	30	17	how	how	WRB
cord-270469-lle32mha	30	18	perturbations	perturbation	NNS
cord-270469-lle32mha	30	19	and	and	CC
cord-270469-lle32mha	30	20	signaling	signal	VBG
cord-270469-lle32mha	30	21	pathways	pathway	NNS
cord-270469-lle32mha	30	22	emerging	emerge	VBG
cord-270469-lle32mha	30	23	from	from	IN
cord-270469-lle32mha	30	24	this	this	DT
cord-270469-lle32mha	30	25	organelle	organelle	NN
cord-270469-lle32mha	30	26	regulate	regulate	VBP
cord-270469-lle32mha	30	27	innate	innate	JJ
cord-270469-lle32mha	30	28	and	and	CC
cord-270469-lle32mha	30	29	inflammatory	inflammatory	JJ
cord-270469-lle32mha	30	30	pathways	pathway	NNS
cord-270469-lle32mha	30	31	.	.	.
cord-270469-lle32mha	31	1	The	the	DT
cord-270469-lle32mha	31	2	ER	ER	NNP
cord-270469-lle32mha	31	3	is	be	VBZ
cord-270469-lle32mha	31	4	an	an	DT
cord-270469-lle32mha	31	5	essential	essential	JJ
cord-270469-lle32mha	31	6	organelle	organelle	NN
cord-270469-lle32mha	31	7	that	that	WDT
cord-270469-lle32mha	31	8	controls	control	VBZ
cord-270469-lle32mha	31	9	the	the	DT
cord-270469-lle32mha	31	10	biogenesis	biogenesis	NN
cord-270469-lle32mha	31	11	of	of	IN
cord-270469-lle32mha	31	12	cellular	cellular	JJ
cord-270469-lle32mha	31	13	components	component	NNS
cord-270469-lle32mha	31	14	including	include	VBG
cord-270469-lle32mha	31	15	proteins	protein	NNS
cord-270469-lle32mha	31	16	,	,	,
cord-270469-lle32mha	31	17	lipids	lipid	NNS
cord-270469-lle32mha	31	18	and	and	CC
cord-270469-lle32mha	31	19	carbohydrates	carbohydrate	NNS
cord-270469-lle32mha	31	20	.	.	.
cord-270469-lle32mha	32	1	It	-PRON-	PRP
cord-270469-lle32mha	32	2	is	be	VBZ
cord-270469-lle32mha	32	3	connected	connect	VBN
cord-270469-lle32mha	32	4	with	with	IN
cord-270469-lle32mha	32	5	the	the	DT
cord-270469-lle32mha	32	6	nuclear	nuclear	JJ
cord-270469-lle32mha	32	7	membrane	membrane	NN
cord-270469-lle32mha	32	8	and	and	CC
cord-270469-lle32mha	32	9	via	via	IN
cord-270469-lle32mha	32	10	mitochondria	mitochondrion	NNS
cord-270469-lle32mha	32	11	associated	associate	VBN
cord-270469-lle32mha	32	12	membranes	membrane	NNS
cord-270469-lle32mha	32	13	(	(	-LRB-
cord-270469-lle32mha	32	14	MAMs	mam	NNS
cord-270469-lle32mha	32	15	)	)	-RRB-
cord-270469-lle32mha	32	16	to	to	IN
cord-270469-lle32mha	32	17	the	the	DT
cord-270469-lle32mha	32	18	power	power	NN
cord-270469-lle32mha	32	19	source	source	NN
cord-270469-lle32mha	32	20	of	of	IN
cord-270469-lle32mha	32	21	the	the	DT
cord-270469-lle32mha	32	22	cell	cell	NN
cord-270469-lle32mha	32	23	:	:	:
cord-270469-lle32mha	32	24	the	the	DT
cord-270469-lle32mha	32	25	mitochondria	mitochondrion	NNS
cord-270469-lle32mha	32	26	.	.	.
cord-270469-lle32mha	33	1	In	in	IN
cord-270469-lle32mha	33	2	eukaryotes	eukaryote	NNS
cord-270469-lle32mha	33	3	,	,	,
cord-270469-lle32mha	33	4	resident	resident	NN
cord-270469-lle32mha	33	5	proteins	protein	NNS
cord-270469-lle32mha	33	6	of	of	IN
cord-270469-lle32mha	33	7	the	the	DT
cord-270469-lle32mha	33	8	endocytic	endocytic	JJ
cord-270469-lle32mha	33	9	and	and	CC
cord-270469-lle32mha	33	10	exocytic	exocytic	JJ
cord-270469-lle32mha	33	11	organelles	organelle	NNS
cord-270469-lle32mha	33	12	as	as	RB
cord-270469-lle32mha	33	13	well	well	RB
cord-270469-lle32mha	33	14	as	as	IN
cord-270469-lle32mha	33	15	cell	cell	NN
cord-270469-lle32mha	33	16	surface	surface	NN
cord-270469-lle32mha	33	17	and	and	CC
cord-270469-lle32mha	33	18	secreted	secrete	VBN
cord-270469-lle32mha	33	19	proteins	protein	NNS
cord-270469-lle32mha	33	20	are	be	VBP
cord-270469-lle32mha	33	21	synthetized	synthetize	VBN
cord-270469-lle32mha	33	22	on	on	IN
cord-270469-lle32mha	33	23	polysomes	polysome	NNS
cord-270469-lle32mha	33	24	anchored	anchor	VBN
cord-270469-lle32mha	33	25	to	to	IN
cord-270469-lle32mha	33	26	ER	ER	NNP
cord-270469-lle32mha	33	27	membrane	membrane	NN
cord-270469-lle32mha	33	28	and	and	CC
cord-270469-lle32mha	33	29	then	then	RB
cord-270469-lle32mha	33	30	,	,	,
cord-270469-lle32mha	33	31	translocated	translocate	VBD
cord-270469-lle32mha	33	32	across	across	IN
cord-270469-lle32mha	33	33	the	the	DT
cord-270469-lle32mha	33	34	membrane	membrane	NN
cord-270469-lle32mha	33	35	into	into	IN
cord-270469-lle32mha	33	36	the	the	DT
cord-270469-lle32mha	33	37	ER	ER	NNP
cord-270469-lle32mha	33	38	lumen	lumen	NN
cord-270469-lle32mha	33	39	.	.	.
cord-270469-lle32mha	34	1	The	the	DT
cord-270469-lle32mha	34	2	ER	ER	NNP
cord-270469-lle32mha	34	3	lumen	lumen	NN
cord-270469-lle32mha	34	4	is	be	VBZ
cord-270469-lle32mha	34	5	rich	rich	JJ
cord-270469-lle32mha	34	6	in	in	IN
cord-270469-lle32mha	34	7	calcium	calcium	NN
cord-270469-lle32mha	34	8	and	and	CC
cord-270469-lle32mha	34	9	its	-PRON-	PRP$
cord-270469-lle32mha	34	10	oxidizing	oxidizing	JJ
cord-270469-lle32mha	34	11	environment	environment	NN
cord-270469-lle32mha	34	12	catalyzes	catalyze	VBZ
cord-270469-lle32mha	34	13	posttranslational	posttranslational	JJ
cord-270469-lle32mha	34	14	modifications	modification	NNS
cord-270469-lle32mha	34	15	such	such	JJ
cord-270469-lle32mha	34	16	as	as	IN
cord-270469-lle32mha	34	17	the	the	DT
cord-270469-lle32mha	34	18	addition	addition	NN
cord-270469-lle32mha	34	19	of	of	IN
cord-270469-lle32mha	34	20	N	n	NN
cord-270469-lle32mha	34	21	-	-	HYPH
cord-270469-lle32mha	34	22	linked	link	VBN
cord-270469-lle32mha	34	23	glycans	glycan	NNS
cord-270469-lle32mha	34	24	and	and	CC
cord-270469-lle32mha	34	25	the	the	DT
cord-270469-lle32mha	34	26	formation	formation	NN
cord-270469-lle32mha	34	27	of	of	IN
cord-270469-lle32mha	34	28	disulfide	disulfide	JJ
cord-270469-lle32mha	34	29	bonds	bond	NNS
cord-270469-lle32mha	34	30	[	[	-LRB-
cord-270469-lle32mha	34	31	10	10	CD
cord-270469-lle32mha	34	32	,	,	,
cord-270469-lle32mha	34	33	11	11	CD
cord-270469-lle32mha	34	34	]	]	-RRB-
cord-270469-lle32mha	34	35	.	.	.
cord-270469-lle32mha	35	1	The	the	DT
cord-270469-lle32mha	35	2	nascent	nascent	JJ
cord-270469-lle32mha	35	3	protein	protein	NN
cord-270469-lle32mha	35	4	must	must	MD
cord-270469-lle32mha	35	5	fold	fold	VB
cord-270469-lle32mha	35	6	via	via	IN
cord-270469-lle32mha	35	7	a	a	DT
cord-270469-lle32mha	35	8	complex	complex	JJ
cord-270469-lle32mha	35	9	process	process	NN
cord-270469-lle32mha	35	10	that	that	WDT
cord-270469-lle32mha	35	11	is	be	VBZ
cord-270469-lle32mha	35	12	monitored	monitor	VBN
cord-270469-lle32mha	35	13	by	by	IN
cord-270469-lle32mha	35	14	resident	resident	NN
cord-270469-lle32mha	35	15	EReprotein	EReprotein	NNP
cord-270469-lle32mha	35	16	chaperones	chaperone	NNS
cord-270469-lle32mha	35	17	and	and	CC
cord-270469-lle32mha	35	18	enzymes	enzyme	NNS
cord-270469-lle32mha	35	19	that	that	WDT
cord-270469-lle32mha	35	20	prevent	prevent	VBP
cord-270469-lle32mha	35	21	aggregation	aggregation	NN
cord-270469-lle32mha	35	22	and	and	CC
cord-270469-lle32mha	35	23	regulate	regulate	VB
cord-270469-lle32mha	35	24	proper	proper	JJ
cord-270469-lle32mha	35	25	folding	folding	NN
cord-270469-lle32mha	35	26	of	of	IN
cord-270469-lle32mha	35	27	newly	newly	RB
cord-270469-lle32mha	35	28	synthetized	synthetize	VBN
cord-270469-lle32mha	35	29	proteins	protein	NNS
cord-270469-lle32mha	35	30	.	.	.
cord-270469-lle32mha	36	1	This	this	DT
cord-270469-lle32mha	36	2	process	process	NN
cord-270469-lle32mha	36	3	being	be	VBG
cord-270469-lle32mha	36	4	essential	essential	JJ
cord-270469-lle32mha	36	5	for	for	IN
cord-270469-lle32mha	36	6	the	the	DT
cord-270469-lle32mha	36	7	production	production	NN
cord-270469-lle32mha	36	8	of	of	IN
cord-270469-lle32mha	36	9	virtually	virtually	RB
cord-270469-lle32mha	36	10	every	every	DT
cord-270469-lle32mha	36	11	secreted	secrete	VBN
cord-270469-lle32mha	36	12	protein	protein	NN
cord-270469-lle32mha	36	13	and	and	CC
cord-270469-lle32mha	36	14	membrane	membrane	NN
cord-270469-lle32mha	36	15	receptor	receptor	NN
cord-270469-lle32mha	36	16	,	,	,
cord-270469-lle32mha	36	17	the	the	DT
cord-270469-lle32mha	36	18	ER	ER	NNP
cord-270469-lle32mha	36	19	is	be	VBZ
cord-270469-lle32mha	36	20	therefore	therefore	RB
cord-270469-lle32mha	36	21	an	an	DT
cord-270469-lle32mha	36	22	essential	essential	JJ
cord-270469-lle32mha	36	23	hub	hub	NN
cord-270469-lle32mha	36	24	controlling	control	VBG
cord-270469-lle32mha	36	25	various	various	JJ
cord-270469-lle32mha	36	26	aspect	aspect	NN
cord-270469-lle32mha	36	27	of	of	IN
cord-270469-lle32mha	36	28	cellular	cellular	JJ
cord-270469-lle32mha	36	29	biology	biology	NN
cord-270469-lle32mha	36	30	including	include	VBG
cord-270469-lle32mha	36	31	virtually	virtually	RB
cord-270469-lle32mha	36	32	all	all	DT
cord-270469-lle32mha	36	33	aspects	aspect	NNS
cord-270469-lle32mha	36	34	of	of	IN
cord-270469-lle32mha	36	35	cellecell	cellecell	NNP
cord-270469-lle32mha	36	36	communication	communication	NN
cord-270469-lle32mha	36	37	and	and	CC
cord-270469-lle32mha	36	38	signal	signal	NN
cord-270469-lle32mha	36	39	transduction	transduction	NN
cord-270469-lle32mha	36	40	pathways	pathway	NNS
cord-270469-lle32mha	36	41	steaming	steam	VBG
cord-270469-lle32mha	36	42	from	from	IN
cord-270469-lle32mha	36	43	membranes	membrane	NNS
cord-270469-lle32mha	36	44	.	.	.
cord-270469-lle32mha	37	1	In	in	IN
cord-270469-lle32mha	37	2	Immunology	Immunology	NNP
cord-270469-lle32mha	37	3	the	the	DT
cord-270469-lle32mha	37	4	ER	er	NN
cord-270469-lle32mha	37	5	is	be	VBZ
cord-270469-lle32mha	37	6	best	well	RBS
cord-270469-lle32mha	37	7	known	know	VBN
cord-270469-lle32mha	37	8	for	for	IN
cord-270469-lle32mha	37	9	its	-PRON-	PRP$
cord-270469-lle32mha	37	10	role	role	NN
cord-270469-lle32mha	37	11	in	in	IN
cord-270469-lle32mha	37	12	antigen	antigen	NN
cord-270469-lle32mha	37	13	presentation	presentation	NN
cord-270469-lle32mha	37	14	,	,	,
cord-270469-lle32mha	37	15	it	-PRON-	PRP
cord-270469-lle32mha	37	16	is	be	VBZ
cord-270469-lle32mha	37	17	the	the	DT
cord-270469-lle32mha	37	18	main	main	JJ
cord-270469-lle32mha	37	19	site	site	NN
cord-270469-lle32mha	37	20	for	for	IN
cord-270469-lle32mha	37	21	the	the	DT
cord-270469-lle32mha	37	22	assembly	assembly	NN
cord-270469-lle32mha	37	23	of	of	IN
cord-270469-lle32mha	37	24	MHC	MHC	NNP
cord-270469-lle32mha	37	25	class	class	NN
cord-270469-lle32mha	37	26	I	I	NNP
cord-270469-lle32mha	37	27	and	and	CC
cord-270469-lle32mha	37	28	MHC	MHC	NNP
cord-270469-lle32mha	37	29	class	class	NN
cord-270469-lle32mha	37	30	II	II	NNP
cord-270469-lle32mha	37	31	molecules	molecule	NNS
cord-270469-lle32mha	37	32	and	and	CC
cord-270469-lle32mha	37	33	is	be	VBZ
cord-270469-lle32mha	37	34	the	the	DT
cord-270469-lle32mha	37	35	location	location	NN
cord-270469-lle32mha	37	36	of	of	IN
cord-270469-lle32mha	37	37	peptide	peptide	NN
cord-270469-lle32mha	37	38	loading	loading	NN
cord-270469-lle32mha	37	39	onto	onto	IN
cord-270469-lle32mha	37	40	MHC	MHC	NNP
cord-270469-lle32mha	37	41	class	class	NN
cord-270469-lle32mha	37	42	I	-PRON-	PRP
cord-270469-lle32mha	37	43	molecules	molecule	NNS
cord-270469-lle32mha	37	44	.	.	.
cord-270469-lle32mha	38	1	Conditions	condition	NNS
cord-270469-lle32mha	38	2	of	of	IN
cord-270469-lle32mha	38	3	ER	ER	NNP
cord-270469-lle32mha	38	4	stress	stress	NN
cord-270469-lle32mha	38	5	occur	occur	VBP
cord-270469-lle32mha	38	6	when	when	WRB
cord-270469-lle32mha	38	7	the	the	DT
cord-270469-lle32mha	38	8	amount	amount	NN
cord-270469-lle32mha	38	9	of	of	IN
cord-270469-lle32mha	38	10	proteins	protein	NNS
cord-270469-lle32mha	38	11	entering	enter	VBG
cord-270469-lle32mha	38	12	the	the	DT
cord-270469-lle32mha	38	13	ER	ER	NNP
cord-270469-lle32mha	38	14	exceeds	exceed	VBZ
cord-270469-lle32mha	38	15	its	-PRON-	PRP$
cord-270469-lle32mha	38	16	folding	folding	NN
cord-270469-lle32mha	38	17	capacity	capacity	NN
cord-270469-lle32mha	38	18	.	.	.
cord-270469-lle32mha	39	1	This	this	DT
cord-270469-lle32mha	39	2	imbalance	imbalance	NN
cord-270469-lle32mha	39	3	induces	induce	VBZ
cord-270469-lle32mha	39	4	a	a	DT
cord-270469-lle32mha	39	5	protective	protective	JJ
cord-270469-lle32mha	39	6	signaling	signal	VBG
cord-270469-lle32mha	39	7	cascade	cascade	NN
cord-270469-lle32mha	39	8	collectively	collectively	RB
cord-270469-lle32mha	39	9	termed	term	VBD
cord-270469-lle32mha	39	10	the	the	DT
cord-270469-lle32mha	39	11	unfolded	unfolded	JJ
cord-270469-lle32mha	39	12	protein	protein	NN
cord-270469-lle32mha	39	13	response	response	NN
cord-270469-lle32mha	39	14	(	(	-LRB-
cord-270469-lle32mha	39	15	UPR	UPR	NNP
cord-270469-lle32mha	39	16	)	)	-RRB-
cord-270469-lle32mha	39	17	or	or	CC
cord-270469-lle32mha	39	18	the	the	DT
cord-270469-lle32mha	39	19	ER	er	NN
cord-270469-lle32mha	39	20	-	-	HYPH
cord-270469-lle32mha	39	21	stress	stress	NN
cord-270469-lle32mha	39	22	response	response	NN
cord-270469-lle32mha	39	23	[	[	-LRB-
cord-270469-lle32mha	39	24	12	12	CD
cord-270469-lle32mha	39	25	,	,	,
cord-270469-lle32mha	39	26	13	13	CD
cord-270469-lle32mha	39	27	]	]	-RRB-
cord-270469-lle32mha	39	28	.	.	.
cord-270469-lle32mha	40	1	Experimentally	experimentally	RB
cord-270469-lle32mha	40	2	,	,	,
cord-270469-lle32mha	40	3	many	many	JJ
cord-270469-lle32mha	40	4	conditions	condition	NNS
cord-270469-lle32mha	40	5	can	can	MD
cord-270469-lle32mha	40	6	trigger	trigger	VB
cord-270469-lle32mha	40	7	the	the	DT
cord-270469-lle32mha	40	8	ERstress	ERstress	NNP
cord-270469-lle32mha	40	9	response	response	NN
cord-270469-lle32mha	40	10	.	.	.
cord-270469-lle32mha	41	1	For	for	IN
cord-270469-lle32mha	41	2	example	example	NN
cord-270469-lle32mha	41	3	,	,	,
cord-270469-lle32mha	41	4	conditions	condition	NNS
cord-270469-lle32mha	41	5	that	that	WDT
cord-270469-lle32mha	41	6	inhibit	inhibit	VBP
cord-270469-lle32mha	41	7	glycosylation	glycosylation	NN
cord-270469-lle32mha	41	8	including	include	VBG
cord-270469-lle32mha	41	9	low	low	JJ
cord-270469-lle32mha	41	10	glucose	glucose	NN
cord-270469-lle32mha	41	11	as	as	RB
cord-270469-lle32mha	41	12	well	well	RB
cord-270469-lle32mha	41	13	as	as	IN
cord-270469-lle32mha	41	14	pharmacological	pharmacological	JJ
cord-270469-lle32mha	41	15	compounds	compound	NNS
cord-270469-lle32mha	41	16	such	such	JJ
cord-270469-lle32mha	41	17	as	as	IN
cord-270469-lle32mha	41	18	tunicamycin	tunicamycin	NNS
cord-270469-lle32mha	41	19	,	,	,
cord-270469-lle32mha	41	20	affect	affect	VB
cord-270469-lle32mha	41	21	the	the	DT
cord-270469-lle32mha	41	22	maturation	maturation	NN
cord-270469-lle32mha	41	23	and	and	CC
cord-270469-lle32mha	41	24	transport	transport	NN
cord-270469-lle32mha	41	25	of	of	IN
cord-270469-lle32mha	41	26	most	most	RBS
cord-270469-lle32mha	41	27	secreted	secrete	VBN
cord-270469-lle32mha	41	28	proteins	protein	NNS
cord-270469-lle32mha	41	29	causing	cause	VBG
cord-270469-lle32mha	41	30	ER	er	NN
cord-270469-lle32mha	41	31	-	-	HYPH
cord-270469-lle32mha	41	32	stress	stress	NN
cord-270469-lle32mha	41	33	.	.	.
cord-270469-lle32mha	42	1	Other	other	JJ
cord-270469-lle32mha	42	2	drugs	drug	NNS
cord-270469-lle32mha	42	3	and	and	CC
cord-270469-lle32mha	42	4	conditions	condition	NNS
cord-270469-lle32mha	42	5	that	that	WDT
cord-270469-lle32mha	42	6	perturb	perturb	VBP
cord-270469-lle32mha	42	7	ER	er	NN
cord-270469-lle32mha	43	1	Ca	ca	RB
cord-270469-lle32mha	43	2	2þ	2þ	CD
cord-270469-lle32mha	43	3	levels	level	NNS
cord-270469-lle32mha	43	4	have	have	VBP
cord-270469-lle32mha	43	5	profound	profound	JJ
cord-270469-lle32mha	43	6	effects	effect	NNS
cord-270469-lle32mha	43	7	on	on	IN
cord-270469-lle32mha	43	8	ER	ER	NNP
cord-270469-lle32mha	43	9	homeostasis	homeostasis	NN
cord-270469-lle32mha	43	10	and	and	CC
cord-270469-lle32mha	43	11	protein	protein	NN
cord-270469-lle32mha	43	12	folding	folding	NN
cord-270469-lle32mha	43	13	.	.	.
cord-270469-lle32mha	44	1	Drugs	drug	NNS
cord-270469-lle32mha	44	2	such	such	JJ
cord-270469-lle32mha	44	3	as	as	IN
cord-270469-lle32mha	44	4	thapsigargin	thapsigargin	NNP
cord-270469-lle32mha	44	5	can	can	MD
cord-270469-lle32mha	44	6	trigger	trigger	VB
cord-270469-lle32mha	44	7	depletion	depletion	NN
cord-270469-lle32mha	44	8	of	of	IN
cord-270469-lle32mha	44	9	ER	ER	NNP
cord-270469-lle32mha	44	10	calcium	calcium	NN
cord-270469-lle32mha	44	11	stores	store	NNS
cord-270469-lle32mha	44	12	leading	lead	VBG
cord-270469-lle32mha	44	13	to	to	IN
cord-270469-lle32mha	44	14	acute	acute	JJ
cord-270469-lle32mha	44	15	ER	er	NN
cord-270469-lle32mha	44	16	-	-	HYPH
cord-270469-lle32mha	44	17	stress	stress	NN
cord-270469-lle32mha	44	18	responses	response	NNS
cord-270469-lle32mha	44	19	.	.	.
cord-270469-lle32mha	45	1	The	the	DT
cord-270469-lle32mha	45	2	ER	ER	NNP
cord-270469-lle32mha	45	3	presents	present	VBZ
cord-270469-lle32mha	45	4	an	an	DT
cord-270469-lle32mha	45	5	oxidizing	oxidizing	JJ
cord-270469-lle32mha	45	6	environment	environment	NN
cord-270469-lle32mha	45	7	that	that	WDT
cord-270469-lle32mha	45	8	can	can	MD
cord-270469-lle32mha	45	9	favor	favor	VB
cord-270469-lle32mha	45	10	protein	protein	NN
cord-270469-lle32mha	45	11	folding	folding	NN
cord-270469-lle32mha	45	12	and	and	CC
cord-270469-lle32mha	45	13	the	the	DT
cord-270469-lle32mha	45	14	formation	formation	NN
cord-270469-lle32mha	45	15	of	of	IN
cord-270469-lle32mha	45	16	disulfide	disulfide	JJ
cord-270469-lle32mha	45	17	bonds	bond	NNS
cord-270469-lle32mha	45	18	.	.	.
cord-270469-lle32mha	46	1	Reducing	reduce	VBG
cord-270469-lle32mha	46	2	agents	agent	NNS
cord-270469-lle32mha	46	3	such	such	JJ
cord-270469-lle32mha	46	4	as	as	IN
cord-270469-lle32mha	46	5	dithiothreitol	dithiothreitol	NNP
cord-270469-lle32mha	46	6	(	(	-LRB-
cord-270469-lle32mha	46	7	DTT	DTT	NNP
cord-270469-lle32mha	46	8	)	)	-RRB-
cord-270469-lle32mha	46	9	affect	affect	VB
cord-270469-lle32mha	46	10	the	the	DT
cord-270469-lle32mha	46	11	oxidizing	oxidizing	JJ
cord-270469-lle32mha	46	12	potential	potential	NN
cord-270469-lle32mha	46	13	of	of	IN
cord-270469-lle32mha	46	14	the	the	DT
cord-270469-lle32mha	46	15	ER	ER	NNP
cord-270469-lle32mha	46	16	leading	lead	VBG
cord-270469-lle32mha	46	17	to	to	IN
cord-270469-lle32mha	46	18	the	the	DT
cord-270469-lle32mha	46	19	accumulation	accumulation	NN
cord-270469-lle32mha	46	20	of	of	IN
cord-270469-lle32mha	46	21	misfolded	misfolded	JJ
cord-270469-lle32mha	46	22	proteins	protein	NNS
cord-270469-lle32mha	46	23	and	and	CC
cord-270469-lle32mha	46	24	the	the	DT
cord-270469-lle32mha	46	25	subsequent	subsequent	JJ
cord-270469-lle32mha	46	26	engagement	engagement	NN
cord-270469-lle32mha	46	27	of	of	IN
cord-270469-lle32mha	46	28	the	the	DT
cord-270469-lle32mha	46	29	ER	er	NN
cord-270469-lle32mha	46	30	-	-	HYPH
cord-270469-lle32mha	46	31	stress	stress	NN
cord-270469-lle32mha	46	32	response	response	NN
cord-270469-lle32mha	46	33	.	.	.
cord-270469-lle32mha	47	1	In	in	IN
cord-270469-lle32mha	47	2	addition	addition	NN
cord-270469-lle32mha	47	3	,	,	,
cord-270469-lle32mha	47	4	various	various	JJ
cord-270469-lle32mha	47	5	physiological	physiological	JJ
cord-270469-lle32mha	47	6	and	and	CC
cord-270469-lle32mha	47	7	pathological	pathological	JJ
cord-270469-lle32mha	47	8	insults	insult	NNS
cord-270469-lle32mha	47	9	that	that	WDT
cord-270469-lle32mha	47	10	perturb	perturb	VBP
cord-270469-lle32mha	47	11	the	the	DT
cord-270469-lle32mha	47	12	cell	cell	NN
cord-270469-lle32mha	47	13	protein	protein	NN
cord-270469-lle32mha	47	14	homeostasis	homeostasis	NN
cord-270469-lle32mha	47	15	network	network	NN
cord-270469-lle32mha	47	16	,	,	,
cord-270469-lle32mha	47	17	a	a	DT
cord-270469-lle32mha	47	18	group	group	NN
cord-270469-lle32mha	47	19	of	of	IN
cord-270469-lle32mha	47	20	interconnected	interconnected	JJ
cord-270469-lle32mha	47	21	pathways	pathway	NNS
cord-270469-lle32mha	47	22	collectively	collectively	RB
cord-270469-lle32mha	47	23	termed	term	VBD
cord-270469-lle32mha	47	24	the	the	DT
cord-270469-lle32mha	47	25	proteostasis	proteostasis	NNP
cord-270469-lle32mha	47	26	network	network	NN
cord-270469-lle32mha	47	27	may	may	MD
cord-270469-lle32mha	47	28	trigger	trigger	VB
cord-270469-lle32mha	47	29	the	the	DT
cord-270469-lle32mha	47	30	ER	er	NN
cord-270469-lle32mha	47	31	-	-	HYPH
cord-270469-lle32mha	47	32	stress	stress	NN
cord-270469-lle32mha	47	33	response	response	NN
cord-270469-lle32mha	47	34	[	[	-LRB-
cord-270469-lle32mha	47	35	14	14	CD
cord-270469-lle32mha	47	36	,	,	,
cord-270469-lle32mha	47	37	15	15	CD
cord-270469-lle32mha	47	38	]	]	-RRB-
cord-270469-lle32mha	47	39	.	.	.
cord-270469-lle32mha	48	1	These	these	DT
cord-270469-lle32mha	48	2	insults	insult	NNS
cord-270469-lle32mha	48	3	include	include	VBP
cord-270469-lle32mha	48	4	alterations	alteration	NNS
cord-270469-lle32mha	48	5	in	in	IN
cord-270469-lle32mha	48	6	cellular	cellular	JJ
cord-270469-lle32mha	48	7	pH	ph	NN
cord-270469-lle32mha	48	8	,	,	,
cord-270469-lle32mha	48	9	inhibition	inhibition	NN
cord-270469-lle32mha	48	10	of	of	IN
cord-270469-lle32mha	48	11	the	the	DT
cord-270469-lle32mha	48	12	proteasome	proteasome	NN
cord-270469-lle32mha	48	13	pathways	pathway	NNS
cord-270469-lle32mha	48	14	,	,	,
cord-270469-lle32mha	48	15	infections	infection	NNS
cord-270469-lle32mha	48	16	with	with	IN
cord-270469-lle32mha	48	17	various	various	JJ
cord-270469-lle32mha	48	18	pathogens	pathogen	NNS
cord-270469-lle32mha	48	19	as	as	RB
cord-270469-lle32mha	48	20	well	well	RB
cord-270469-lle32mha	48	21	as	as	IN
cord-270469-lle32mha	48	22	metabolic	metabolic	JJ
cord-270469-lle32mha	48	23	changes	change	NNS
cord-270469-lle32mha	48	24	associated	associate	VBN
cord-270469-lle32mha	48	25	with	with	IN
cord-270469-lle32mha	48	26	cancer	cancer	NN
cord-270469-lle32mha	48	27	.	.	.
cord-270469-lle32mha	49	1	ERsignaling	ersignale	VBG
cord-270469-lle32mha	49	2	pathways	pathway	NNS
cord-270469-lle32mha	49	3	and	and	CC
cord-270469-lle32mha	49	4	the	the	DT
cord-270469-lle32mha	49	5	ER	er	NN
cord-270469-lle32mha	49	6	-	-	HYPH
cord-270469-lle32mha	49	7	stress	stress	NN
cord-270469-lle32mha	49	8	response	response	NN
cord-270469-lle32mha	49	9	are	be	VBP
cord-270469-lle32mha	49	10	among	among	IN
cord-270469-lle32mha	49	11	the	the	DT
cord-270469-lle32mha	49	12	major	major	JJ
cord-270469-lle32mha	49	13	and	and	CC
cord-270469-lle32mha	49	14	best	well	RBS
cord-270469-lle32mha	49	15	-	-	HYPH
cord-270469-lle32mha	49	16	characterized	characterize	VBN
cord-270469-lle32mha	49	17	components	component	NNS
cord-270469-lle32mha	49	18	of	of	IN
cord-270469-lle32mha	49	19	the	the	DT
cord-270469-lle32mha	49	20	proteastasis	proteastasis	NNP
cord-270469-lle32mha	49	21	network	network	NN
cord-270469-lle32mha	49	22	pathways	pathway	NNS
cord-270469-lle32mha	49	23	.	.	.
cord-270469-lle32mha	50	1	The	the	DT
cord-270469-lle32mha	50	2	ER	er	NN
cord-270469-lle32mha	50	3	-	-	HYPH
cord-270469-lle32mha	50	4	stress	stress	NN
cord-270469-lle32mha	50	5	response	response	NN
cord-270469-lle32mha	50	6	is	be	VBZ
cord-270469-lle32mha	50	7	a	a	DT
cord-270469-lle32mha	50	8	highly	highly	RB
cord-270469-lle32mha	50	9	controlled	control	VBN
cord-270469-lle32mha	50	10	process	process	NN
cord-270469-lle32mha	50	11	that	that	WDT
cord-270469-lle32mha	50	12	adapt	adapt	VBP
cord-270469-lle32mha	50	13	to	to	TO
cord-270469-lle32mha	50	14	specific	specific	VB
cord-270469-lle32mha	50	15	insults	insult	NNS
cord-270469-lle32mha	50	16	to	to	TO
cord-270469-lle32mha	50	17	optimize	optimize	VB
cord-270469-lle32mha	50	18	and	and	CC
cord-270469-lle32mha	50	19	orchestrate	orchestrate	VB
cord-270469-lle32mha	50	20	an	an	DT
cord-270469-lle32mha	50	21	appropriate	appropriate	JJ
cord-270469-lle32mha	50	22	response	response	NN
cord-270469-lle32mha	50	23	.	.	.
cord-270469-lle32mha	51	1	While	while	IN
cord-270469-lle32mha	51	2	this	this	DT
cord-270469-lle32mha	51	3	response	response	NN
cord-270469-lle32mha	51	4	may	may	MD
cord-270469-lle32mha	51	5	differ	differ	VB
cord-270469-lle32mha	51	6	from	from	IN
cord-270469-lle32mha	51	7	one	one	CD
cord-270469-lle32mha	51	8	condition	condition	NN
cord-270469-lle32mha	51	9	to	to	IN
cord-270469-lle32mha	51	10	another	another	DT
cord-270469-lle32mha	51	11	,	,	,
cord-270469-lle32mha	51	12	a	a	DT
cord-270469-lle32mha	51	13	general	general	JJ
cord-270469-lle32mha	51	14	picture	picture	NN
cord-270469-lle32mha	51	15	of	of	IN
cord-270469-lle32mha	51	16	signaling	signal	VBG
cord-270469-lle32mha	51	17	events	event	NNS
cord-270469-lle32mha	51	18	emerge	emerge	VBP
cord-270469-lle32mha	51	19	.	.	.
cord-270469-lle32mha	52	1	The	the	DT
cord-270469-lle32mha	52	2	attenuation	attenuation	NN
cord-270469-lle32mha	52	3	of	of	IN
cord-270469-lle32mha	52	4	translation	translation	NN
cord-270469-lle32mha	52	5	is	be	VBZ
cord-270469-lle32mha	52	6	among	among	IN
cord-270469-lle32mha	52	7	the	the	DT
cord-270469-lle32mha	52	8	first	first	JJ
cord-270469-lle32mha	52	9	things	thing	NNS
cord-270469-lle32mha	52	10	that	that	WDT
cord-270469-lle32mha	52	11	are	be	VBP
cord-270469-lle32mha	52	12	observed	observe	VBN
cord-270469-lle32mha	52	13	upon	upon	IN
cord-270469-lle32mha	52	14	induction	induction	NN
cord-270469-lle32mha	52	15	of	of	IN
cord-270469-lle32mha	52	16	ER	er	NN
cord-270469-lle32mha	52	17	-	-	HYPH
cord-270469-lle32mha	52	18	stress	stress	NN
cord-270469-lle32mha	52	19	.	.	.
cord-270469-lle32mha	53	1	This	this	DT
cord-270469-lle32mha	53	2	occurs	occur	VBZ
cord-270469-lle32mha	53	3	within	within	IN
cord-270469-lle32mha	53	4	minutes	minute	NNS
cord-270469-lle32mha	53	5	to	to	IN
cord-270469-lle32mha	53	6	hours	hour	NNS
cord-270469-lle32mha	53	7	of	of	IN
cord-270469-lle32mha	53	8	ER	er	NN
cord-270469-lle32mha	53	9	-	-	HYPH
cord-270469-lle32mha	53	10	stress	stress	NN
cord-270469-lle32mha	53	11	activation	activation	NN
cord-270469-lle32mha	53	12	and	and	CC
cord-270469-lle32mha	53	13	prevent	prevent	VBP
cord-270469-lle32mha	53	14	further	further	JJ
cord-270469-lle32mha	53	15	translational	translational	JJ
cord-270469-lle32mha	53	16	overload	overload	NN
cord-270469-lle32mha	53	17	of	of	IN
cord-270469-lle32mha	53	18	the	the	DT
cord-270469-lle32mha	53	19	ER	ER	NNP
cord-270469-lle32mha	53	20	.	.	.
cord-270469-lle32mha	54	1	Perturbation	perturbation	NN
cord-270469-lle32mha	54	2	of	of	IN
cord-270469-lle32mha	54	3	ERhomeostasis	ERhomeostasis	NNP
cord-270469-lle32mha	54	4	also	also	RB
cord-270469-lle32mha	54	5	results	result	VBZ
cord-270469-lle32mha	54	6	in	in	IN
cord-270469-lle32mha	54	7	the	the	DT
cord-270469-lle32mha	54	8	up	up	JJ
cord-270469-lle32mha	54	9	-	-	HYPH
cord-270469-lle32mha	54	10	regulation	regulation	NN
cord-270469-lle32mha	54	11	of	of	IN
cord-270469-lle32mha	54	12	genes	gene	NNS
cord-270469-lle32mha	54	13	involved	involve	VBN
cord-270469-lle32mha	54	14	in	in	IN
cord-270469-lle32mha	54	15	ER	ER	NNP
cord-270469-lle32mha	54	16	biogenesis	biogenesis	NN
cord-270469-lle32mha	54	17	,	,	,
cord-270469-lle32mha	54	18	in	in	IN
cord-270469-lle32mha	54	19	chaperoning	chaperone	VBG
cord-270469-lle32mha	54	20	and	and	CC
cord-270469-lle32mha	54	21	folding	folding	NN
cord-270469-lle32mha	54	22	of	of	IN
cord-270469-lle32mha	54	23	proteins	protein	NNS
cord-270469-lle32mha	54	24	as	as	RB
cord-270469-lle32mha	54	25	well	well	RB
cord-270469-lle32mha	54	26	as	as	IN
cord-270469-lle32mha	54	27	in	in	IN
cord-270469-lle32mha	54	28	the	the	DT
cord-270469-lle32mha	54	29	quality	quality	NN
cord-270469-lle32mha	54	30	control	control	NN
cord-270469-lle32mha	54	31	mechanisms	mechanism	NNS
cord-270469-lle32mha	54	32	that	that	WDT
cord-270469-lle32mha	54	33	target	target	VBP
cord-270469-lle32mha	54	34	and	and	CC
cord-270469-lle32mha	54	35	ensure	ensure	VB
cord-270469-lle32mha	54	36	elimination	elimination	NN
cord-270469-lle32mha	54	37	of	of	IN
cord-270469-lle32mha	54	38	malfunctioning	malfunction	VBG
cord-270469-lle32mha	54	39	proteins	protein	NNS
cord-270469-lle32mha	54	40	including	include	VBG
cord-270469-lle32mha	54	41	the	the	DT
cord-270469-lle32mha	54	42	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	54	43	-	-	HYPH
cord-270469-lle32mha	54	44	reticulum	reticulum	NN
cord-270469-lle32mha	54	45	-	-	HYPH
cord-270469-lle32mha	54	46	associated	associate	VBN
cord-270469-lle32mha	54	47	protein	protein	NN
cord-270469-lle32mha	54	48	degradation	degradation	NN
cord-270469-lle32mha	54	49	(	(	-LRB-
cord-270469-lle32mha	54	50	ERAD	ERAD	NNP
cord-270469-lle32mha	54	51	)	)	-RRB-
cord-270469-lle32mha	54	52	pathway	pathway	NN
cord-270469-lle32mha	54	53	.	.	.
cord-270469-lle32mha	55	1	The	the	DT
cord-270469-lle32mha	55	2	aim	aim	NN
cord-270469-lle32mha	55	3	of	of	IN
cord-270469-lle32mha	55	4	these	these	DT
cord-270469-lle32mha	55	5	responses	response	NNS
cord-270469-lle32mha	55	6	is	be	VBZ
cord-270469-lle32mha	55	7	to	to	TO
cord-270469-lle32mha	55	8	help	help	VB
cord-270469-lle32mha	55	9	the	the	DT
cord-270469-lle32mha	55	10	cell	cell	NN
cord-270469-lle32mha	55	11	cope	cope	VB
cord-270469-lle32mha	55	12	with	with	IN
cord-270469-lle32mha	55	13	the	the	DT
cord-270469-lle32mha	55	14	stress	stress	NN
cord-270469-lle32mha	55	15	,	,	,
cord-270469-lle32mha	55	16	remove	remove	VB
cord-270469-lle32mha	55	17	the	the	DT
cord-270469-lle32mha	55	18	accumulated	accumulate	VBN
cord-270469-lle32mha	55	19	protein	protein	NN
cord-270469-lle32mha	55	20	load	load	NN
cord-270469-lle32mha	55	21	,	,	,
cord-270469-lle32mha	55	22	increase	increase	VB
cord-270469-lle32mha	55	23	ER	ER	NNP
cord-270469-lle32mha	55	24	capacity	capacity	NN
cord-270469-lle32mha	55	25	and	and	CC
cord-270469-lle32mha	55	26	restore	restore	VB
cord-270469-lle32mha	55	27	normal	normal	JJ
cord-270469-lle32mha	55	28	function	function	NN
cord-270469-lle32mha	55	29	of	of	IN
cord-270469-lle32mha	55	30	the	the	DT
cord-270469-lle32mha	55	31	ER	ER	NNP
cord-270469-lle32mha	55	32	.	.	.
cord-270469-lle32mha	56	1	In	in	IN
cord-270469-lle32mha	56	2	conditions	condition	NNS
cord-270469-lle32mha	56	3	of	of	IN
cord-270469-lle32mha	56	4	acute	acute	JJ
cord-270469-lle32mha	56	5	and	and	CC
cord-270469-lle32mha	56	6	prolonged	prolonged	JJ
cord-270469-lle32mha	56	7	stress	stress	NN
cord-270469-lle32mha	56	8	,	,	,
cord-270469-lle32mha	56	9	the	the	DT
cord-270469-lle32mha	56	10	response	response	NN
cord-270469-lle32mha	56	11	changes	change	VBZ
cord-270469-lle32mha	56	12	from	from	IN
cord-270469-lle32mha	56	13	promoting	promote	VBG
cord-270469-lle32mha	56	14	survival	survival	NN
cord-270469-lle32mha	56	15	to	to	IN
cord-270469-lle32mha	56	16	inducing	induce	VBG
cord-270469-lle32mha	56	17	cell	cell	NN
cord-270469-lle32mha	56	18	death	death	NN
cord-270469-lle32mha	56	19	.	.	.
cord-270469-lle32mha	57	1	The	the	DT
cord-270469-lle32mha	57	2	point	point	NN
cord-270469-lle32mha	57	3	at	at	IN
cord-270469-lle32mha	57	4	which	which	WDT
cord-270469-lle32mha	57	5	the	the	DT
cord-270469-lle32mha	57	6	'	'	``
cord-270469-lle32mha	57	7	apoptotic	apoptotic	JJ
cord-270469-lle32mha	57	8	switch	switch	NN
cord-270469-lle32mha	57	9	'	'	''
cord-270469-lle32mha	57	10	is	be	VBZ
cord-270469-lle32mha	57	11	activated	activate	VBN
cord-270469-lle32mha	57	12	has	have	VBZ
cord-270469-lle32mha	57	13	not	not	RB
cord-270469-lle32mha	57	14	yet	yet	RB
cord-270469-lle32mha	57	15	been	be	VBN
cord-270469-lle32mha	57	16	determined	determine	VBN
cord-270469-lle32mha	57	17	,	,	,
cord-270469-lle32mha	57	18	and	and	CC
cord-270469-lle32mha	57	19	may	may	MD
cord-270469-lle32mha	57	20	vary	vary	VB
cord-270469-lle32mha	57	21	form	form	VB
cord-270469-lle32mha	57	22	cell	cell	NN
cord-270469-lle32mha	57	23	to	to	IN
cord-270469-lle32mha	57	24	cell	cell	NN
cord-270469-lle32mha	57	25	.	.	.
cord-270469-lle32mha	58	1	The	the	DT
cord-270469-lle32mha	58	2	mechanisms	mechanism	NNS
cord-270469-lle32mha	58	3	of	of	IN
cord-270469-lle32mha	58	4	ER	er	NN
cord-270469-lle32mha	58	5	-	-	HYPH
cord-270469-lle32mha	58	6	stress	stress	NN
cord-270469-lle32mha	58	7	mediated	mediate	VBN
cord-270469-lle32mha	58	8	apoptosis	apoptosis	NN
cord-270469-lle32mha	58	9	are	be	VBP
cord-270469-lle32mha	58	10	yet	yet	RB
cord-270469-lle32mha	58	11	poorly	poorly	RB
cord-270469-lle32mha	58	12	understood	understand	VBN
cord-270469-lle32mha	58	13	but	but	CC
cord-270469-lle32mha	58	14	may	may	MD
cord-270469-lle32mha	58	15	involve	involve	VB
cord-270469-lle32mha	58	16	the	the	DT
cord-270469-lle32mha	58	17	intrinsic	intrinsic	JJ
cord-270469-lle32mha	58	18	apoptotic	apoptotic	JJ
cord-270469-lle32mha	58	19	pathway	pathway	NN
cord-270469-lle32mha	58	20	that	that	WDT
cord-270469-lle32mha	58	21	lead	lead	VBP
cord-270469-lle32mha	58	22	to	to	IN
cord-270469-lle32mha	58	23	release	release	NN
cord-270469-lle32mha	58	24	of	of	IN
cord-270469-lle32mha	58	25	cytochrome	cytochrome	NN
cord-270469-lle32mha	58	26	c	c	NN
cord-270469-lle32mha	58	27	from	from	IN
cord-270469-lle32mha	58	28	the	the	DT
cord-270469-lle32mha	58	29	mitochondria	mitochondrion	NNS
cord-270469-lle32mha	58	30	and	and	CC
cord-270469-lle32mha	58	31	activation	activation	NN
cord-270469-lle32mha	58	32	of	of	IN
cord-270469-lle32mha	58	33	the	the	DT
cord-270469-lle32mha	58	34	caspase-9	caspase-9	NNP
cord-270469-lle32mha	58	35	apoptosome	apoptosome	NN
cord-270469-lle32mha	58	36	[	[	-LRB-
cord-270469-lle32mha	58	37	16e18	16e18	CD
cord-270469-lle32mha	58	38	]	]	-RRB-
cord-270469-lle32mha	58	39	.	.	.
cord-270469-lle32mha	59	1	In	in	IN
cord-270469-lle32mha	59	2	mammalian	mammalian	JJ
cord-270469-lle32mha	59	3	cells	cell	NNS
cord-270469-lle32mha	59	4	,	,	,
cord-270469-lle32mha	59	5	the	the	DT
cord-270469-lle32mha	59	6	ER	er	NN
cord-270469-lle32mha	59	7	-	-	HYPH
cord-270469-lle32mha	59	8	stress	stress	NN
cord-270469-lle32mha	59	9	response	response	NN
cord-270469-lle32mha	59	10	is	be	VBZ
cord-270469-lle32mha	59	11	mediated	mediate	VBN
cord-270469-lle32mha	59	12	by	by	IN
cord-270469-lle32mha	59	13	at	at	RB
cord-270469-lle32mha	59	14	least	least	RBS
cord-270469-lle32mha	59	15	three	three	CD
cord-270469-lle32mha	59	16	signaling	signal	VBG
cord-270469-lle32mha	59	17	pathways	pathway	NNS
cord-270469-lle32mha	59	18	that	that	WDT
cord-270469-lle32mha	59	19	operate	operate	VBP
cord-270469-lle32mha	59	20	in	in	IN
cord-270469-lle32mha	59	21	parallel	parallel	NN
cord-270469-lle32mha	59	22	(	(	-LRB-
cord-270469-lle32mha	59	23	Fig	fig	NN
cord-270469-lle32mha	59	24	.	.	NNP
cord-270469-lle32mha	59	25	2	2	CD
cord-270469-lle32mha	59	26	)	)	-RRB-
cord-270469-lle32mha	59	27	.	.	.
cord-270469-lle32mha	60	1	Each	each	DT
cord-270469-lle32mha	60	2	pathway	pathway	NN
cord-270469-lle32mha	60	3	steams	steam	VBZ
cord-270469-lle32mha	60	4	from	from	IN
cord-270469-lle32mha	60	5	a	a	DT
cord-270469-lle32mha	60	6	class	class	NN
cord-270469-lle32mha	60	7	of	of	IN
cord-270469-lle32mha	60	8	transmembrane	transmembrane	NN
cord-270469-lle32mha	60	9	proteins	protein	NNS
cord-270469-lle32mha	60	10	anchored	anchor	VBN
cord-270469-lle32mha	60	11	at	at	IN
cord-270469-lle32mha	60	12	the	the	DT
cord-270469-lle32mha	60	13	ER	er	NN
cord-270469-lle32mha	60	14	:	:	:
cord-270469-lle32mha	61	1	IRE1	IRE1	NNP
cord-270469-lle32mha	61	2	(	(	-LRB-
cord-270469-lle32mha	61	3	Inositol	inositol	NN
cord-270469-lle32mha	61	4	-	-	HYPH
cord-270469-lle32mha	61	5	requiring	require	VBG
cord-270469-lle32mha	61	6	enzyme	enzyme	NN
cord-270469-lle32mha	61	7	1	1	CD
cord-270469-lle32mha	61	8	)	)	-RRB-
cord-270469-lle32mha	61	9	PERK	perk	VB
cord-270469-lle32mha	61	10	(	(	-LRB-
cord-270469-lle32mha	61	11	PKR	PKR	NNP
cord-270469-lle32mha	61	12	-	-	HYPH
cord-270469-lle32mha	61	13	like	like	JJ
cord-270469-lle32mha	61	14	ER	ER	NNP
cord-270469-lle32mha	61	15	kinase	kinase	NN
cord-270469-lle32mha	61	16	)	)	-RRB-
cord-270469-lle32mha	61	17	,	,	,
cord-270469-lle32mha	61	18	and	and	CC
cord-270469-lle32mha	61	19	ATF6	ATF6	NNP
cord-270469-lle32mha	61	20	(	(	-LRB-
cord-270469-lle32mha	62	1	activating	activate	VBG
cord-270469-lle32mha	62	2	The	the	DT
cord-270469-lle32mha	62	3	state	state	NN
cord-270469-lle32mha	62	4	of	of	IN
cord-270469-lle32mha	62	5	a	a	DT
cord-270469-lle32mha	62	6	tissue	tissue	NN
cord-270469-lle32mha	62	7	can	can	MD
cord-270469-lle32mha	62	8	range	range	VB
cord-270469-lle32mha	62	9	from	from	IN
cord-270469-lle32mha	62	10	healthy	healthy	JJ
cord-270469-lle32mha	62	11	,	,	,
cord-270469-lle32mha	62	12	to	to	IN
cord-270469-lle32mha	62	13	stressed	stressed	JJ
cord-270469-lle32mha	62	14	or	or	CC
cord-270469-lle32mha	62	15	malfunctioning	malfunction	VBG
cord-270469-lle32mha	62	16	,	,	,
cord-270469-lle32mha	62	17	to	to	TO
cord-270469-lle32mha	62	18	irreversibly	irreversibly	RB
cord-270469-lle32mha	62	19	damaged	damage	VBN
cord-270469-lle32mha	62	20	.	.	.
cord-270469-lle32mha	63	1	Damaged	damage	VBN
cord-270469-lle32mha	63	2	cells	cell	NNS
cord-270469-lle32mha	63	3	release	release	VBP
cord-270469-lle32mha	63	4	DAMP	damp	VBP
cord-270469-lle32mha	63	5	,	,	,
cord-270469-lle32mha	63	6	that	that	WDT
cord-270469-lle32mha	63	7	directly	directly	RB
cord-270469-lle32mha	63	8	engage	engage	VB
cord-270469-lle32mha	63	9	innate	innate	JJ
cord-270469-lle32mha	63	10	immune	immune	JJ
cord-270469-lle32mha	63	11	receptors	receptor	NNS
cord-270469-lle32mha	63	12	such	such	JJ
cord-270469-lle32mha	63	13	as	as	IN
cord-270469-lle32mha	63	14	TLRs	TLRs	NNP
cord-270469-lle32mha	63	15	,	,	,
cord-270469-lle32mha	63	16	NLRs	nlr	NNS
cord-270469-lle32mha	63	17	or	or	CC
cord-270469-lle32mha	63	18	RAGE	rage	NN
cord-270469-lle32mha	63	19	receptors	receptor	NNS
cord-270469-lle32mha	63	20	.	.	.
cord-270469-lle32mha	64	1	In	in	IN
cord-270469-lle32mha	64	2	contrast	contrast	NN
cord-270469-lle32mha	64	3	,	,	,
cord-270469-lle32mha	64	4	tissue	tissue	NN
cord-270469-lle32mha	64	5	stress	stress	NN
cord-270469-lle32mha	64	6	or	or	CC
cord-270469-lle32mha	64	7	malfunction	malfunction	NN
cord-270469-lle32mha	64	8	is	be	VBZ
cord-270469-lle32mha	64	9	a	a	DT
cord-270469-lle32mha	64	10	reversible	reversible	JJ
cord-270469-lle32mha	64	11	state	state	NN
cord-270469-lle32mha	64	12	that	that	WDT
cord-270469-lle32mha	64	13	triggers	trigger	VBZ
cord-270469-lle32mha	64	14	an	an	DT
cord-270469-lle32mha	64	15	adaptation	adaptation	NN
cord-270469-lle32mha	64	16	response	response	NN
cord-270469-lle32mha	64	17	aimed	aim	VBN
cord-270469-lle32mha	64	18	at	at	IN
cord-270469-lle32mha	64	19	restoring	restore	VBG
cord-270469-lle32mha	64	20	tissue	tissue	NN
cord-270469-lle32mha	64	21	homeostasis	homeostasis	NN
cord-270469-lle32mha	64	22	.	.	.
cord-270469-lle32mha	65	1	Stressed	stressed	JJ
cord-270469-lle32mha	65	2	tissue	tissue	NN
cord-270469-lle32mha	65	3	may	may	MD
cord-270469-lle32mha	65	4	also	also	RB
cord-270469-lle32mha	65	5	trigger	trigger	VB
cord-270469-lle32mha	65	6	danger	danger	NN
cord-270469-lle32mha	65	7	signals	signal	NNS
cord-270469-lle32mha	65	8	or	or	CC
cord-270469-lle32mha	65	9	stress	stress	NN
cord-270469-lle32mha	65	10	signals	signal	NNS
cord-270469-lle32mha	65	11	that	that	WDT
cord-270469-lle32mha	65	12	could	could	MD
cord-270469-lle32mha	65	13	contribute	contribute	VB
cord-270469-lle32mha	65	14	to	to	IN
cord-270469-lle32mha	65	15	the	the	DT
cord-270469-lle32mha	65	16	upreglation	upreglation	NN
cord-270469-lle32mha	65	17	of	of	IN
cord-270469-lle32mha	65	18	inflammatory	inflammatory	JJ
cord-270469-lle32mha	65	19	and	and	CC
cord-270469-lle32mha	65	20	innate	innate	JJ
cord-270469-lle32mha	65	21	immune	immune	JJ
cord-270469-lle32mha	65	22	responses	response	NNS
cord-270469-lle32mha	65	23	.	.	.
cord-270469-lle32mha	66	1	transcription	transcription	NN
cord-270469-lle32mha	66	2	factor	factor	NN
cord-270469-lle32mha	66	3	6	6	CD
cord-270469-lle32mha	66	4	)	)	-RRB-
cord-270469-lle32mha	66	5	.	.	.
cord-270469-lle32mha	67	1	Activation	activation	NN
cord-270469-lle32mha	67	2	of	of	IN
cord-270469-lle32mha	67	3	these	these	DT
cord-270469-lle32mha	67	4	three	three	CD
cord-270469-lle32mha	67	5	signaling	signal	VBG
cord-270469-lle32mha	67	6	branches	branch	NNS
cord-270469-lle32mha	67	7	control	control	VBP
cord-270469-lle32mha	67	8	the	the	DT
cord-270469-lle32mha	67	9	expression	expression	NN
cord-270469-lle32mha	67	10	of	of	IN
cord-270469-lle32mha	67	11	a	a	DT
cord-270469-lle32mha	67	12	few	few	JJ
cord-270469-lle32mha	67	13	proximal	proximal	JJ
cord-270469-lle32mha	67	14	ER	er	NN
cord-270469-lle32mha	67	15	-	-	HYPH
cord-270469-lle32mha	67	16	stress	stress	NN
cord-270469-lle32mha	67	17	related	relate	VBN
cord-270469-lle32mha	67	18	transcription	transcription	NN
cord-270469-lle32mha	67	19	factors	factor	NNS
cord-270469-lle32mha	67	20	and	and	CC
cord-270469-lle32mha	67	21	signaling	signal	VBG
cord-270469-lle32mha	67	22	events	event	NNS
cord-270469-lle32mha	67	23	that	that	WDT
cord-270469-lle32mha	67	24	orchestrate	orchestrate	VBP
cord-270469-lle32mha	67	25	the	the	DT
cord-270469-lle32mha	67	26	transcriptional	transcriptional	JJ
cord-270469-lle32mha	67	27	upregulation	upregulation	NN
cord-270469-lle32mha	67	28	of	of	IN
cord-270469-lle32mha	67	29	the	the	DT
cord-270469-lle32mha	67	30	universe	universe	NN
cord-270469-lle32mha	67	31	of	of	IN
cord-270469-lle32mha	67	32	genes	gene	NNS
cord-270469-lle32mha	67	33	involved	involve	VBN
cord-270469-lle32mha	67	34	in	in	IN
cord-270469-lle32mha	67	35	restoring	restore	VBG
cord-270469-lle32mha	67	36	ER	ER	NNP
cord-270469-lle32mha	67	37	functions	function	NNS
cord-270469-lle32mha	67	38	[	[	-LRB-
cord-270469-lle32mha	67	39	16	16	CD
cord-270469-lle32mha	67	40	,	,	,
cord-270469-lle32mha	67	41	19	19	CD
cord-270469-lle32mha	67	42	,	,	,
cord-270469-lle32mha	67	43	20	20	CD
cord-270469-lle32mha	67	44	]	]	-RRB-
cord-270469-lle32mha	67	45	.	.	.
cord-270469-lle32mha	68	1	IRE1	IRE1	NNP
cord-270469-lle32mha	68	2	is	be	VBZ
cord-270469-lle32mha	68	3	the	the	DT
cord-270469-lle32mha	68	4	most	most	RBS
cord-270469-lle32mha	68	5	conserved	conserved	JJ
cord-270469-lle32mha	68	6	branch	branch	NN
cord-270469-lle32mha	68	7	,	,	,
cord-270469-lle32mha	68	8	the	the	DT
cord-270469-lle32mha	68	9	only	only	JJ
cord-270469-lle32mha	68	10	one	one	CD
cord-270469-lle32mha	68	11	present	present	NN
cord-270469-lle32mha	68	12	in	in	IN
cord-270469-lle32mha	68	13	lower	low	JJR
cord-270469-lle32mha	68	14	eukaryotes	eukaryote	NNS
cord-270469-lle32mha	68	15	and	and	CC
cord-270469-lle32mha	68	16	probably	probably	RB
cord-270469-lle32mha	68	17	the	the	DT
cord-270469-lle32mha	68	18	best	well	RBS
cord-270469-lle32mha	68	19	-	-	HYPH
cord-270469-lle32mha	68	20	studied	study	VBN
cord-270469-lle32mha	68	21	branch	branch	NN
cord-270469-lle32mha	68	22	of	of	IN
cord-270469-lle32mha	68	23	the	the	DT
cord-270469-lle32mha	68	24	ER	ER	NNP
cord-270469-lle32mha	68	25	-	-	HYPH
cord-270469-lle32mha	68	26	stress	stress	NN
cord-270469-lle32mha	68	27	response	response	NN
cord-270469-lle32mha	68	28	.	.	.
cord-270469-lle32mha	69	1	In	in	IN
cord-270469-lle32mha	69	2	yeast	yeast	NN
cord-270469-lle32mha	69	3	,	,	,
cord-270469-lle32mha	69	4	IRE1	IRE1	NNP
cord-270469-lle32mha	69	5	triggers	trigger	VBZ
cord-270469-lle32mha	69	6	the	the	DT
cord-270469-lle32mha	69	7	full	full	JJ
cord-270469-lle32mha	69	8	ER	er	NN
cord-270469-lle32mha	69	9	-	-	HYPH
cord-270469-lle32mha	69	10	stress	stress	NN
cord-270469-lle32mha	69	11	response	response	NN
cord-270469-lle32mha	69	12	program	program	NN
cord-270469-lle32mha	69	13	,	,	,
cord-270469-lle32mha	69	14	whereas	whereas	IN
cord-270469-lle32mha	69	15	in	in	IN
cord-270469-lle32mha	69	16	higher	high	JJR
cord-270469-lle32mha	69	17	eukaryotes	eukaryote	NNS
cord-270469-lle32mha	69	18	the	the	DT
cord-270469-lle32mha	69	19	program	program	NN
cord-270469-lle32mha	69	20	requires	require	VBZ
cord-270469-lle32mha	69	21	cooperation	cooperation	NN
cord-270469-lle32mha	69	22	between	between	IN
cord-270469-lle32mha	69	23	the	the	DT
cord-270469-lle32mha	69	24	three	three	CD
cord-270469-lle32mha	69	25	branches	branch	NNS
cord-270469-lle32mha	69	26	of	of	IN
cord-270469-lle32mha	69	27	the	the	DT
cord-270469-lle32mha	69	28	ER	er	NN
cord-270469-lle32mha	69	29	-	-	HYPH
cord-270469-lle32mha	69	30	stress	stress	NN
cord-270469-lle32mha	69	31	response	response	NN
cord-270469-lle32mha	69	32	.	.	.
cord-270469-lle32mha	70	1	IRE1	IRE1	NNP
cord-270469-lle32mha	70	2	transmembrane	transmembrane	NN
cord-270469-lle32mha	70	3	region	region	NN
cord-270469-lle32mha	70	4	is	be	VBZ
cord-270469-lle32mha	70	5	flanked	flank	VBN
cord-270469-lle32mha	70	6	by	by	IN
cord-270469-lle32mha	70	7	a	a	DT
cord-270469-lle32mha	70	8	sensor	sensor	NN
cord-270469-lle32mha	70	9	unit	unit	NN
cord-270469-lle32mha	70	10	at	at	IN
cord-270469-lle32mha	70	11	its	-PRON-	PRP$
cord-270469-lle32mha	70	12	N	n	CD
cord-270469-lle32mha	70	13	-	-	HYPH
cord-270469-lle32mha	70	14	terminus	terminus	NN
cord-270469-lle32mha	70	15	that	that	WDT
cord-270469-lle32mha	70	16	localize	localize	VBP
cord-270469-lle32mha	70	17	in	in	IN
cord-270469-lle32mha	70	18	the	the	DT
cord-270469-lle32mha	70	19	ER	ER	NNP
cord-270469-lle32mha	70	20	lumen	lumen	NN
cord-270469-lle32mha	70	21	and	and	CC
cord-270469-lle32mha	70	22	a	a	DT
cord-270469-lle32mha	70	23	C	c	NN
cord-270469-lle32mha	70	24	-	-	HYPH
cord-270469-lle32mha	70	25	terminal	terminal	NN
cord-270469-lle32mha	70	26	portion	portion	NN
cord-270469-lle32mha	70	27	that	that	WDT
cord-270469-lle32mha	70	28	reside	reside	VBP
cord-270469-lle32mha	70	29	in	in	IN
cord-270469-lle32mha	70	30	the	the	DT
cord-270469-lle32mha	70	31	cytosol	cytosol	NN
cord-270469-lle32mha	70	32	.	.	.
cord-270469-lle32mha	71	1	The	the	DT
cord-270469-lle32mha	71	2	cytosolic	cytosolic	JJ
cord-270469-lle32mha	71	3	portion	portion	NN
cord-270469-lle32mha	71	4	of	of	IN
cord-270469-lle32mha	71	5	IRE1	IRE1	NNP
cord-270469-lle32mha	71	6	contains	contain	VBZ
cord-270469-lle32mha	71	7	two	two	CD
cord-270469-lle32mha	71	8	functional	functional	JJ
cord-270469-lle32mha	71	9	units	unit	NNS
cord-270469-lle32mha	71	10	:	:	:
cord-270469-lle32mha	71	11	a	a	DT
cord-270469-lle32mha	71	12	Ser	Ser	NNP
cord-270469-lle32mha	71	13	/	/	SYM
cord-270469-lle32mha	71	14	Thr	Thr	NNP
cord-270469-lle32mha	71	15	protein	protein	NN
cord-270469-lle32mha	71	16	kinase	kinase	NN
cord-270469-lle32mha	71	17	and	and	CC
cord-270469-lle32mha	71	18	an	an	DT
cord-270469-lle32mha	71	19	endoribonuclease	endoribonuclease	NN
cord-270469-lle32mha	71	20	.	.	.
cord-270469-lle32mha	72	1	Oligomerization	Oligomerization	NNP
cord-270469-lle32mha	72	2	of	of	IN
cord-270469-lle32mha	72	3	IRE1	IRE1	NNP
cord-270469-lle32mha	72	4	at	at	IN
cord-270469-lle32mha	72	5	the	the	DT
cord-270469-lle32mha	72	6	ER	ER	NNP
cord-270469-lle32mha	72	7	,	,	,
cord-270469-lle32mha	72	8	triggers	trigger	VBZ
cord-270469-lle32mha	72	9	its	-PRON-	PRP$
cord-270469-lle32mha	72	10	ribonuclease	ribonuclease	NN
cord-270469-lle32mha	72	11	activity	activity	NN
cord-270469-lle32mha	72	12	and	and	CC
cord-270469-lle32mha	72	13	cleaves	cleave	VBZ
cord-270469-lle32mha	72	14	,	,	,
cord-270469-lle32mha	72	15	at	at	IN
cord-270469-lle32mha	72	16	two	two	CD
cord-270469-lle32mha	72	17	closely	closely	RB
cord-270469-lle32mha	72	18	located	located	JJ
cord-270469-lle32mha	72	19	and	and	CC
cord-270469-lle32mha	72	20	distinct	distinct	JJ
cord-270469-lle32mha	72	21	sites	site	NNS
cord-270469-lle32mha	72	22	,	,	,
cord-270469-lle32mha	72	23	the	the	DT
cord-270469-lle32mha	72	24	mRNA	mrna	NN
cord-270469-lle32mha	72	25	of	of	IN
cord-270469-lle32mha	72	26	the	the	DT
cord-270469-lle32mha	72	27	X	X	NNP
cord-270469-lle32mha	72	28	-	-	HYPH
cord-270469-lle32mha	72	29	box	box	NN
cord-270469-lle32mha	72	30	binding	bind	VBG
cord-270469-lle32mha	72	31	protein-1	protein-1	NNP
cord-270469-lle32mha	72	32	(	(	-LRB-
cord-270469-lle32mha	72	33	XBP1	XBP1	NNP
cord-270469-lle32mha	72	34	)	)	-RRB-
cord-270469-lle32mha	72	35	gene	gene	NN
cord-270469-lle32mha	72	36	.	.	.
cord-270469-lle32mha	73	1	This	this	DT
cord-270469-lle32mha	73	2	cleavage	cleavage	NN
cord-270469-lle32mha	73	3	results	result	VBZ
cord-270469-lle32mha	73	4	in	in	IN
cord-270469-lle32mha	73	5	the	the	DT
cord-270469-lle32mha	73	6	excision	excision	NN
cord-270469-lle32mha	73	7	of	of	IN
cord-270469-lle32mha	73	8	a	a	DT
cord-270469-lle32mha	73	9	mini	mini	JJ
cord-270469-lle32mha	73	10	intron	intron	NN
cord-270469-lle32mha	73	11	of	of	IN
cord-270469-lle32mha	73	12	26	26	CD
cord-270469-lle32mha	73	13	nucleotides	nucleotide	NNS
cord-270469-lle32mha	73	14	in	in	IN
cord-270469-lle32mha	73	15	mammals	mammal	NNS
cord-270469-lle32mha	73	16	.	.	.
cord-270469-lle32mha	74	1	Upon	upon	IN
cord-270469-lle32mha	74	2	ligation	ligation	NN
cord-270469-lle32mha	74	3	,	,	,
cord-270469-lle32mha	74	4	mature	mature	VB
cord-270469-lle32mha	74	5	XBP1	XBP1	NNP
cord-270469-lle32mha	74	6	mRNA	mrna	NN
cord-270469-lle32mha	74	7	encodes	encode	VBZ
cord-270469-lle32mha	74	8	a	a	DT
cord-270469-lle32mha	74	9	functional	functional	JJ
cord-270469-lle32mha	74	10	transcription	transcription	NN
cord-270469-lle32mha	74	11	factor	factor	NN
cord-270469-lle32mha	74	12	.	.	.
cord-270469-lle32mha	75	1	IRE1	IRE1	NNP
cord-270469-lle32mha	75	2	mediated	mediate	VBN
cord-270469-lle32mha	75	3	removal	removal	NN
cord-270469-lle32mha	75	4	of	of	IN
cord-270469-lle32mha	75	5	the	the	DT
cord-270469-lle32mha	75	6	26	26	CD
cord-270469-lle32mha	75	7	nucleotides	nucleotide	NNS
cord-270469-lle32mha	75	8	mini	mini	JJ
cord-270469-lle32mha	75	9	intron	intron	NN
cord-270469-lle32mha	75	10	open	open	VBP
cord-270469-lle32mha	75	11	a	a	DT
cord-270469-lle32mha	75	12	new	new	JJ
cord-270469-lle32mha	75	13	translation	translation	NN
cord-270469-lle32mha	75	14	reading	reading	NN
cord-270469-lle32mha	75	15	frame	frame	NN
cord-270469-lle32mha	75	16	at	at	IN
cord-270469-lle32mha	75	17	the	the	DT
cord-270469-lle32mha	75	18	C	c	NN
cord-270469-lle32mha	75	19	-	-	HYPH
cord-270469-lle32mha	75	20	terminus	terminus	NN
cord-270469-lle32mha	75	21	of	of	IN
cord-270469-lle32mha	75	22	the	the	DT
cord-270469-lle32mha	75	23	protein	protein	NN
cord-270469-lle32mha	75	24	coding	code	VBG
cord-270469-lle32mha	75	25	for	for	IN
cord-270469-lle32mha	75	26	a	a	DT
cord-270469-lle32mha	75	27	potent	potent	JJ
cord-270469-lle32mha	75	28	transactivation	transactivation	NN
cord-270469-lle32mha	75	29	domain	domain	NN
cord-270469-lle32mha	75	30	.	.	.
cord-270469-lle32mha	76	1	Therefore	therefore	RB
cord-270469-lle32mha	76	2	,	,	,
cord-270469-lle32mha	76	3	by	by	IN
cord-270469-lle32mha	76	4	a	a	DT
cord-270469-lle32mha	76	5	unique	unique	JJ
cord-270469-lle32mha	76	6	mechanism	mechanism	NN
cord-270469-lle32mha	76	7	in	in	IN
cord-270469-lle32mha	76	8	mammals	mammal	NNS
cord-270469-lle32mha	76	9	,	,	,
cord-270469-lle32mha	76	10	unrelated	unrelated	JJ
cord-270469-lle32mha	76	11	to	to	IN
cord-270469-lle32mha	76	12	regular	regular	JJ
cord-270469-lle32mha	76	13	splicing	splicing	NN
cord-270469-lle32mha	76	14	,	,	,
cord-270469-lle32mha	76	15	IRE1	IRE1	NNP
cord-270469-lle32mha	76	16	converts	convert	VBZ
cord-270469-lle32mha	76	17	an	an	DT
cord-270469-lle32mha	76	18	inactive	inactive	JJ
cord-270469-lle32mha	76	19	XBP1	XBP1	NNP
cord-270469-lle32mha	76	20	protein	protein	NN
cord-270469-lle32mha	76	21	sequence	sequence	NN
cord-270469-lle32mha	76	22	into	into	IN
cord-270469-lle32mha	76	23	an	an	DT
cord-270469-lle32mha	76	24	active	active	JJ
cord-270469-lle32mha	76	25	transcription	transcription	NN
cord-270469-lle32mha	76	26	factor	factor	NN
cord-270469-lle32mha	76	27	.	.	.
cord-270469-lle32mha	77	1	Active	active	JJ
cord-270469-lle32mha	77	2	XBP1	XBP1	NNP
cord-270469-lle32mha	77	3	referred	refer	VBD
cord-270469-lle32mha	77	4	hereby	hereby	RB
cord-270469-lle32mha	77	5	as	as	IN
cord-270469-lle32mha	77	6	XBP1s	XBP1s	NNP
cord-270469-lle32mha	77	7	,	,	,
cord-270469-lle32mha	77	8	contribute	contribute	VB
cord-270469-lle32mha	77	9	to	to	IN
cord-270469-lle32mha	77	10	the	the	DT
cord-270469-lle32mha	77	11	regulation	regulation	NN
cord-270469-lle32mha	77	12	of	of	IN
cord-270469-lle32mha	77	13	genes	gene	NNS
cord-270469-lle32mha	77	14	involved	involve	VBN
cord-270469-lle32mha	77	15	in	in	IN
cord-270469-lle32mha	77	16	different	different	JJ
cord-270469-lle32mha	77	17	processes	process	NNS
cord-270469-lle32mha	77	18	including	include	VBG
cord-270469-lle32mha	77	19	protein	protein	NN
cord-270469-lle32mha	77	20	folding	folding	NN
cord-270469-lle32mha	77	21	,	,	,
cord-270469-lle32mha	77	22	mechanisms	mechanism	NNS
cord-270469-lle32mha	77	23	controlling	control	VBG
cord-270469-lle32mha	77	24	protein	protein	NN
cord-270469-lle32mha	77	25	quality	quality	NN
cord-270469-lle32mha	77	26	as	as	RB
cord-270469-lle32mha	77	27	well	well	RB
cord-270469-lle32mha	77	28	as	as	IN
cord-270469-lle32mha	77	29	a	a	DT
cord-270469-lle32mha	77	30	broad	broad	JJ
cord-270469-lle32mha	77	31	array	array	NN
cord-270469-lle32mha	77	32	of	of	IN
cord-270469-lle32mha	77	33	genes	gene	NNS
cord-270469-lle32mha	77	34	involved	involve	VBN
cord-270469-lle32mha	77	35	in	in	IN
cord-270469-lle32mha	77	36	almost	almost	RB
cord-270469-lle32mha	77	37	every	every	DT
cord-270469-lle32mha	77	38	aspect	aspect	NN
cord-270469-lle32mha	77	39	of	of	IN
cord-270469-lle32mha	77	40	ER	ER	NNP
cord-270469-lle32mha	77	41	function	function	NN
cord-270469-lle32mha	77	42	,	,	,
cord-270469-lle32mha	77	43	physiology	physiology	NN
cord-270469-lle32mha	77	44	and	and	CC
cord-270469-lle32mha	77	45	biogenesis	biogenesis	NN
cord-270469-lle32mha	77	46	[	[	-LRB-
cord-270469-lle32mha	77	47	21	21	CD
cord-270469-lle32mha	77	48	,	,	,
cord-270469-lle32mha	77	49	22	22	CD
cord-270469-lle32mha	77	50	]	]	-RRB-
cord-270469-lle32mha	77	51	.	.	.
cord-270469-lle32mha	78	1	Early	early	JJ
cord-270469-lle32mha	78	2	studies	study	NNS
cord-270469-lle32mha	78	3	on	on	IN
cord-270469-lle32mha	78	4	XBP1	XBP1	NNP
cord-270469-lle32mha	78	5	highlighted	highlight	VBD
cord-270469-lle32mha	78	6	the	the	DT
cord-270469-lle32mha	78	7	role	role	NN
cord-270469-lle32mha	78	8	of	of	IN
cord-270469-lle32mha	78	9	the	the	DT
cord-270469-lle32mha	78	10	ER	er	NN
cord-270469-lle32mha	78	11	-	-	HYPH
cord-270469-lle32mha	78	12	stress	stress	NN
cord-270469-lle32mha	78	13	response	response	NN
cord-270469-lle32mha	78	14	pathways	pathway	NNS
cord-270469-lle32mha	78	15	in	in	IN
cord-270469-lle32mha	78	16	the	the	DT
cord-270469-lle32mha	78	17	development	development	NN
cord-270469-lle32mha	78	18	and	and	CC
cord-270469-lle32mha	78	19	regulation	regulation	NN
cord-270469-lle32mha	78	20	of	of	IN
cord-270469-lle32mha	78	21	secretory	secretory	JJ
cord-270469-lle32mha	78	22	cells	cell	NNS
cord-270469-lle32mha	78	23	including	include	VBG
cord-270469-lle32mha	78	24	plasma	plasma	NN
cord-270469-lle32mha	78	25	B	b	NN
cord-270469-lle32mha	78	26	cells	cell	NNS
cord-270469-lle32mha	78	27	.	.	.
cord-270469-lle32mha	79	1	XBP1-deficient	XBP1-deficient	NNP
cord-270469-lle32mha	79	2	B	b	NN
cord-270469-lle32mha	79	3	cells	cell	NNS
cord-270469-lle32mha	79	4	are	be	VBP
cord-270469-lle32mha	79	5	unable	unable	JJ
cord-270469-lle32mha	79	6	to	to	TO
cord-270469-lle32mha	79	7	differentiate	differentiate	VB
cord-270469-lle32mha	79	8	into	into	IN
cord-270469-lle32mha	79	9	antibody	antibody	NN
cord-270469-lle32mha	79	10	-	-	HYPH
cord-270469-lle32mha	79	11	secreting	secrete	VBG
cord-270469-lle32mha	79	12	plasma	plasma	NN
cord-270469-lle32mha	79	13	cells	cell	NNS
cord-270469-lle32mha	79	14	[	[	-LRB-
cord-270469-lle32mha	79	15	23	23	CD
cord-270469-lle32mha	79	16	,	,	,
cord-270469-lle32mha	79	17	24	24	CD
cord-270469-lle32mha	79	18	]	]	-RRB-
cord-270469-lle32mha	79	19	and	and	CC
cord-270469-lle32mha	79	20	antibody	antibody	NN
cord-270469-lle32mha	79	21	production	production	NN
cord-270469-lle32mha	79	22	in	in	IN
cord-270469-lle32mha	79	23	vivo	vivo	NN
cord-270469-lle32mha	79	24	in	in	IN
cord-270469-lle32mha	79	25	response	response	NN
cord-270469-lle32mha	79	26	to	to	IN
cord-270469-lle32mha	79	27	antigenic	antigenic	JJ
cord-270469-lle32mha	79	28	challenge	challenge	NN
cord-270469-lle32mha	79	29	is	be	VBZ
cord-270469-lle32mha	79	30	impaired	impair	VBN
cord-270469-lle32mha	79	31	by	by	IN
cord-270469-lle32mha	79	32	XBP1	XBP1	NNP
cord-270469-lle32mha	79	33	deficiency	deficiency	NN
cord-270469-lle32mha	79	34	.	.	.
cord-270469-lle32mha	80	1	Importantly	importantly	RB
cord-270469-lle32mha	80	2	it	-PRON-	PRP
cord-270469-lle32mha	80	3	was	be	VBD
cord-270469-lle32mha	80	4	shown	show	VBN
cord-270469-lle32mha	80	5	that	that	WDT
cord-270469-lle32mha	80	6	activated	activate	VBN
cord-270469-lle32mha	80	7	B	b	NN
cord-270469-lle32mha	80	8	cells	cell	NNS
cord-270469-lle32mha	80	9	undergo	undergo	VBP
cord-270469-lle32mha	80	10	XBP1	XBP1	NNP
cord-270469-lle32mha	80	11	mRNA	mrna	NN
cord-270469-lle32mha	80	12	maturation	maturation	NN
cord-270469-lle32mha	80	13	to	to	TO
cord-270469-lle32mha	80	14	produce	produce	VB
cord-270469-lle32mha	80	15	XBP1s	XBP1s	NNP
cord-270469-lle32mha	80	16	in	in	IN
cord-270469-lle32mha	80	17	order	order	NN
cord-270469-lle32mha	80	18	to	to	TO
cord-270469-lle32mha	80	19	promote	promote	VB
cord-270469-lle32mha	80	20	ER	ER	NNP
cord-270469-lle32mha	80	21	expansion	expansion	NN
cord-270469-lle32mha	80	22	and	and	CC
cord-270469-lle32mha	80	23	develop	develop	VB
cord-270469-lle32mha	80	24	the	the	DT
cord-270469-lle32mha	80	25	secretory	secretory	JJ
cord-270469-lle32mha	80	26	capacity	capacity	NN
cord-270469-lle32mha	80	27	of	of	IN
cord-270469-lle32mha	80	28	plasma	plasma	NN
cord-270469-lle32mha	80	29	cells	cell	NNS
cord-270469-lle32mha	80	30	[	[	-LRB-
cord-270469-lle32mha	80	31	25	25	CD
cord-270469-lle32mha	80	32	,	,	,
cord-270469-lle32mha	80	33	26	26	CD
cord-270469-lle32mha	80	34	]	]	-RRB-
cord-270469-lle32mha	80	35	.	.	.
cord-270469-lle32mha	81	1	However	however	RB
cord-270469-lle32mha	81	2	,	,	,
cord-270469-lle32mha	81	3	what	what	WDT
cord-270469-lle32mha	81	4	drives	drive	VBZ
cord-270469-lle32mha	81	5	IRE1	IRE1	NNP
cord-270469-lle32mha	81	6	activation	activation	NN
cord-270469-lle32mha	81	7	in	in	IN
cord-270469-lle32mha	81	8	B	b	NN
cord-270469-lle32mha	81	9	cells	cell	NNS
cord-270469-lle32mha	81	10	is	be	VBZ
cord-270469-lle32mha	81	11	still	still	RB
cord-270469-lle32mha	81	12	unclear	unclear	JJ
cord-270469-lle32mha	81	13	.	.	.
cord-270469-lle32mha	82	1	In	in	IN
cord-270469-lle32mha	82	2	B	b	NN
cord-270469-lle32mha	82	3	cells	cell	NNS
cord-270469-lle32mha	82	4	,	,	,
cord-270469-lle32mha	82	5	XBP1	XBP1	NNP
cord-270469-lle32mha	82	6	activation	activation	NN
cord-270469-lle32mha	82	7	is	be	VBZ
cord-270469-lle32mha	82	8	not	not	RB
cord-270469-lle32mha	82	9	impaired	impair	VBN
cord-270469-lle32mha	82	10	by	by	IN
cord-270469-lle32mha	82	11	IgM	IgM	NNP
cord-270469-lle32mha	82	12	deficiency	deficiency	NN
cord-270469-lle32mha	82	13	[	[	-LRB-
cord-270469-lle32mha	82	14	27	27	CD
cord-270469-lle32mha	82	15	,	,	,
cord-270469-lle32mha	82	16	28	28	CD
cord-270469-lle32mha	82	17	]	]	-RRB-
cord-270469-lle32mha	82	18	suggesting	suggest	VBG
cord-270469-lle32mha	82	19	that	that	IN
cord-270469-lle32mha	82	20	massive	massive	JJ
cord-270469-lle32mha	82	21	immunoglobulin	immunoglobulin	NN
cord-270469-lle32mha	82	22	production	production	NN
cord-270469-lle32mha	82	23	per	per	FW
cord-270469-lle32mha	82	24	se	se	FW
cord-270469-lle32mha	82	25	is	be	VBZ
cord-270469-lle32mha	82	26	not	not	RB
cord-270469-lle32mha	82	27	the	the	DT
cord-270469-lle32mha	82	28	cause	cause	NN
cord-270469-lle32mha	82	29	of	of	IN
cord-270469-lle32mha	82	30	XBP1s	XBP1s	NNP
cord-270469-lle32mha	82	31	activation	activation	NN
cord-270469-lle32mha	82	32	and	and	CC
cord-270469-lle32mha	82	33	that	that	IN
cord-270469-lle32mha	82	34	IRE1	IRE1	NNP
cord-270469-lle32mha	82	35	/	/	SYM
cord-270469-lle32mha	82	36	XBP1	XBP1	NNP
cord-270469-lle32mha	82	37	activation	activation	NN
cord-270469-lle32mha	82	38	may	may	MD
cord-270469-lle32mha	82	39	by	by	IN
cord-270469-lle32mha	82	40	part	part	NN
cord-270469-lle32mha	82	41	of	of	IN
cord-270469-lle32mha	82	42	a	a	DT
cord-270469-lle32mha	82	43	preemptive	preemptive	JJ
cord-270469-lle32mha	82	44	differentiation	differentiation	NN
cord-270469-lle32mha	82	45	program	program	NN
cord-270469-lle32mha	82	46	rather	rather	RB
cord-270469-lle32mha	82	47	than	than	IN
cord-270469-lle32mha	82	48	as	as	IN
cord-270469-lle32mha	82	49	a	a	DT
cord-270469-lle32mha	82	50	consequence	consequence	NN
cord-270469-lle32mha	82	51	of	of	IN
cord-270469-lle32mha	82	52	ER	ER	NNP
cord-270469-lle32mha	82	53	overload	overload	NN
cord-270469-lle32mha	82	54	.	.	.
cord-270469-lle32mha	83	1	In	in	IN
cord-270469-lle32mha	83	2	addition	addition	NN
cord-270469-lle32mha	83	3	to	to	IN
cord-270469-lle32mha	83	4	XBP1	XBP1	NNP
cord-270469-lle32mha	83	5	activation	activation	NN
cord-270469-lle32mha	83	6	,	,	,
cord-270469-lle32mha	83	7	IRE1	IRE1	NNP
cord-270469-lle32mha	83	8	ribonuclease	ribonuclease	NN
cord-270469-lle32mha	83	9	activity	activity	NN
cord-270469-lle32mha	83	10	has	have	VBZ
cord-270469-lle32mha	83	11	other	other	JJ
cord-270469-lle32mha	83	12	functions	function	NNS
cord-270469-lle32mha	83	13	.	.	.
cord-270469-lle32mha	84	1	Upon	upon	IN
cord-270469-lle32mha	84	2	sustained	sustained	JJ
cord-270469-lle32mha	84	3	and	and	CC
cord-270469-lle32mha	84	4	acute	acute	JJ
cord-270469-lle32mha	84	5	ER	er	NN
cord-270469-lle32mha	84	6	-	-	HYPH
cord-270469-lle32mha	84	7	stress	stress	NN
cord-270469-lle32mha	84	8	,	,	,
cord-270469-lle32mha	84	9	IRE1	IRE1	NNP
cord-270469-lle32mha	84	10	may	may	MD
cord-270469-lle32mha	84	11	contribute	contribute	VB
cord-270469-lle32mha	84	12	to	to	IN
cord-270469-lle32mha	84	13	the	the	DT
cord-270469-lle32mha	84	14	degradation	degradation	NN
cord-270469-lle32mha	84	15	of	of	IN
cord-270469-lle32mha	84	16	membrane	membrane	NN
cord-270469-lle32mha	84	17	-	-	HYPH
cord-270469-lle32mha	84	18	associated	associate	VBN
cord-270469-lle32mha	84	19	mRNAs	mrna	VBD
cord-270469-lle32mha	84	20	through	through	IN
cord-270469-lle32mha	84	21	a	a	DT
cord-270469-lle32mha	84	22	process	process	NN
cord-270469-lle32mha	84	23	known	know	VBN
cord-270469-lle32mha	84	24	as	as	IN
cord-270469-lle32mha	84	25	regulated	regulate	VBN
cord-270469-lle32mha	84	26	IRE1	IRE1	NNP
cord-270469-lle32mha	84	27	dependent	dependent	JJ
cord-270469-lle32mha	84	28	decay	decay	NN
cord-270469-lle32mha	84	29	or	or	CC
cord-270469-lle32mha	84	30	RIDD	RIDD	NNP
cord-270469-lle32mha	84	31	[	[	-LRB-
cord-270469-lle32mha	84	32	27	27	CD
cord-270469-lle32mha	84	33	,	,	,
cord-270469-lle32mha	84	34	29	29	CD
cord-270469-lle32mha	84	35	,	,	,
cord-270469-lle32mha	84	36	30	30	CD
cord-270469-lle32mha	84	37	]	]	-RRB-
cord-270469-lle32mha	84	38	.	.	.
cord-270469-lle32mha	85	1	The	the	DT
cord-270469-lle32mha	85	2	exact	exact	JJ
cord-270469-lle32mha	85	3	role	role	NN
cord-270469-lle32mha	85	4	of	of	IN
cord-270469-lle32mha	85	5	RIDD	RIDD	NNP
cord-270469-lle32mha	85	6	is	be	VBZ
cord-270469-lle32mha	85	7	unknown	unknown	JJ
cord-270469-lle32mha	85	8	.	.	.
cord-270469-lle32mha	86	1	It	-PRON-	PRP
cord-270469-lle32mha	86	2	is	be	VBZ
cord-270469-lle32mha	86	3	unclear	unclear	JJ
cord-270469-lle32mha	86	4	if	if	IN
cord-270469-lle32mha	86	5	it	-PRON-	PRP
cord-270469-lle32mha	86	6	solely	solely	RB
cord-270469-lle32mha	86	7	contribute	contribute	VBP
cord-270469-lle32mha	86	8	to	to	IN
cord-270469-lle32mha	86	9	decreasing	decrease	VBG
cord-270469-lle32mha	86	10	protein	protein	NN
cord-270469-lle32mha	86	11	load	load	NN
cord-270469-lle32mha	86	12	in	in	IN
cord-270469-lle32mha	86	13	the	the	DT
cord-270469-lle32mha	86	14	ER	er	NN
cord-270469-lle32mha	86	15	or	or	CC
cord-270469-lle32mha	86	16	is	be	VBZ
cord-270469-lle32mha	86	17	part	part	NN
cord-270469-lle32mha	86	18	of	of	IN
cord-270469-lle32mha	86	19	the	the	DT
cord-270469-lle32mha	86	20	induction	induction	NN
cord-270469-lle32mha	86	21	of	of	IN
cord-270469-lle32mha	86	22	the	the	DT
cord-270469-lle32mha	86	23	apoptosis	apoptosis	NN
cord-270469-lle32mha	86	24	phase	phase	NN
cord-270469-lle32mha	86	25	as	as	IN
cord-270469-lle32mha	86	26	suggested	suggest	VBN
cord-270469-lle32mha	86	27	by	by	IN
cord-270469-lle32mha	86	28	experiments	experiment	NNS
cord-270469-lle32mha	86	29	showing	show	VBG
cord-270469-lle32mha	86	30	increased	increase	VBN
cord-270469-lle32mha	86	31	ER	er	NN
cord-270469-lle32mha	86	32	-	-	HYPH
cord-270469-lle32mha	86	33	stress	stress	NN
cord-270469-lle32mha	86	34	induced	induce	VBN
cord-270469-lle32mha	86	35	apoptosis	apoptosis	NN
cord-270469-lle32mha	86	36	in	in	IN
cord-270469-lle32mha	86	37	cells	cell	NNS
cord-270469-lle32mha	86	38	in	in	IN
cord-270469-lle32mha	86	39	which	which	WDT
cord-270469-lle32mha	86	40	IRE1	IRE1	NNP
cord-270469-lle32mha	86	41	activity	activity	NN
cord-270469-lle32mha	86	42	was	be	VBD
cord-270469-lle32mha	86	43	manipulated	manipulate	VBN
cord-270469-lle32mha	86	44	to	to	TO
cord-270469-lle32mha	86	45	promote	promote	VB
cord-270469-lle32mha	86	46	RIDD	RIDD	NNP
cord-270469-lle32mha	86	47	activation	activation	NN
cord-270469-lle32mha	86	48	[	[	-LRB-
cord-270469-lle32mha	86	49	30	30	CD
cord-270469-lle32mha	86	50	,	,	,
cord-270469-lle32mha	86	51	31	31	CD
cord-270469-lle32mha	86	52	]	]	-RRB-
cord-270469-lle32mha	86	53	.	.	.
cord-270469-lle32mha	87	1	PERK	PERK	NNP
cord-270469-lle32mha	87	2	is	be	VBZ
cord-270469-lle32mha	87	3	an	an	DT
cord-270469-lle32mha	87	4	ER	ER	NNP
cord-270469-lle32mha	87	5	anchored	anchor	VBN
cord-270469-lle32mha	87	6	kinase	kinase	NN
cord-270469-lle32mha	88	1	that	that	IN
cord-270469-lle32mha	88	2	upon	upon	IN
cord-270469-lle32mha	88	3	activation	activation	NN
cord-270469-lle32mha	88	4	oligomerizes	oligomerize	NNS
cord-270469-lle32mha	88	5	and	and	CC
cord-270469-lle32mha	88	6	autophosphorylate	autophosphorylate	NN
cord-270469-lle32mha	88	7	.	.	.
cord-270469-lle32mha	89	1	It	-PRON-	PRP
cord-270469-lle32mha	89	2	kinase	kinase	VBZ
cord-270469-lle32mha	89	3	activity	activity	NN
cord-270469-lle32mha	89	4	phosphorylates	phosphorylate	VBZ
cord-270469-lle32mha	89	5	the	the	DT
cord-270469-lle32mha	89	6	translation	translation	NN
cord-270469-lle32mha	89	7	initiation	initiation	NN
cord-270469-lle32mha	89	8	factor	factor	NN
cord-270469-lle32mha	89	9	EIF2a	EIF2a	NNP
cord-270469-lle32mha	89	10	,	,	,
cord-270469-lle32mha	89	11	transiently	transiently	RB
cord-270469-lle32mha	89	12	decreasing	decrease	VBG
cord-270469-lle32mha	89	13	overall	overall	JJ
cord-270469-lle32mha	89	14	protein	protein	NN
cord-270469-lle32mha	89	15	translation	translation	NN
cord-270469-lle32mha	89	16	.	.	.
cord-270469-lle32mha	90	1	This	this	DT
cord-270469-lle32mha	90	2	helps	help	VBZ
cord-270469-lle32mha	90	3	reducing	reduce	VBG
cord-270469-lle32mha	90	4	folding	folding	NN
cord-270469-lle32mha	90	5	requirements	requirement	NNS
cord-270469-lle32mha	90	6	in	in	IN
cord-270469-lle32mha	90	7	the	the	DT
cord-270469-lle32mha	90	8	ER	er	NN
cord-270469-lle32mha	90	9	.	.	.
cord-270469-lle32mha	91	1	By	by	IN
cord-270469-lle32mha	91	2	phosphorylating	phosphorylate	VBG
cord-270469-lle32mha	91	3	EIF2a	EIF2a	NNP
cord-270469-lle32mha	91	4	at	at	IN
cord-270469-lle32mha	91	5	serine	serine	NN
cord-270469-lle32mha	91	6	51	51	CD
cord-270469-lle32mha	91	7	PERK	perk	NN
cord-270469-lle32mha	91	8	inhibits	inhibit	VBZ
cord-270469-lle32mha	91	9	the	the	DT
cord-270469-lle32mha	91	10	guanine	guanine	NN
cord-270469-lle32mha	91	11	nucleotide	nucleotide	JJ
cord-270469-lle32mha	91	12	exchange	exchange	NN
cord-270469-lle32mha	91	13	factor	factor	NN
cord-270469-lle32mha	91	14	EIF2B	EIF2B	''
cord-270469-lle32mha	91	15	,	,	,
cord-270469-lle32mha	91	16	a	a	DT
cord-270469-lle32mha	91	17	factor	factor	NN
cord-270469-lle32mha	91	18	involved	involve	VBN
cord-270469-lle32mha	91	19	in	in	IN
cord-270469-lle32mha	91	20	the	the	DT
cord-270469-lle32mha	91	21	recycling	recycling	NN
cord-270469-lle32mha	91	22	of	of	IN
cord-270469-lle32mha	91	23	EIF2a	EIF2a	NNP
cord-270469-lle32mha	91	24	to	to	IN
cord-270469-lle32mha	91	25	its	-PRON-	PRP$
cord-270469-lle32mha	91	26	active	active	JJ
cord-270469-lle32mha	91	27	GTP	gtp	NN
cord-270469-lle32mha	91	28	-	-	HYPH
cord-270469-lle32mha	91	29	bound	bind	VBN
cord-270469-lle32mha	91	30	form	form	NN
cord-270469-lle32mha	91	31	[	[	-LRB-
cord-270469-lle32mha	91	32	32e34	32e34	CD
cord-270469-lle32mha	91	33	]	]	-RRB-
cord-270469-lle32mha	91	34	.	.	.
cord-270469-lle32mha	92	1	EIF2a	eif2a	JJ
cord-270469-lle32mha	92	2	phosphorylation	phosphorylation	NN
cord-270469-lle32mha	92	3	can	can	MD
cord-270469-lle32mha	92	4	be	be	VB
cord-270469-lle32mha	92	5	targeted	target	VBN
cord-270469-lle32mha	92	6	by	by	IN
cord-270469-lle32mha	92	7	phosphatases	phosphatase	NNS
cord-270469-lle32mha	92	8	,	,	,
cord-270469-lle32mha	92	9	such	such	JJ
cord-270469-lle32mha	92	10	as	as	IN
cord-270469-lle32mha	92	11	Growth	growth	NN
cord-270469-lle32mha	92	12	arrest	arrest	NN
cord-270469-lle32mha	92	13	and	and	CC
cord-270469-lle32mha	92	14	DNAdamage	dnadamage	VBP
cord-270469-lle32mha	92	15	inducible	inducible	JJ
cord-270469-lle32mha	92	16	protein-34	protein-34	NN
cord-270469-lle32mha	92	17	(	(	-LRB-
cord-270469-lle32mha	92	18	GADD34	GADD34	NNP
cord-270469-lle32mha	92	19	)	)	-RRB-
cord-270469-lle32mha	92	20	[	[	-LRB-
cord-270469-lle32mha	92	21	35	35	CD
cord-270469-lle32mha	92	22	,	,	,
cord-270469-lle32mha	92	23	36	36	CD
cord-270469-lle32mha	92	24	]	]	-RRB-
cord-270469-lle32mha	92	25	that	that	WDT
cord-270469-lle32mha	92	26	contribute	contribute	VBP
cord-270469-lle32mha	92	27	to	to	IN
cord-270469-lle32mha	92	28	the	the	DT
cord-270469-lle32mha	92	29	resolution	resolution	NN
cord-270469-lle32mha	92	30	of	of	IN
cord-270469-lle32mha	92	31	the	the	DT
cord-270469-lle32mha	92	32	stress	stress	NN
cord-270469-lle32mha	92	33	responses	response	NNS
cord-270469-lle32mha	92	34	.	.	.
cord-270469-lle32mha	93	1	Some	some	DT
cord-270469-lle32mha	93	2	mRNA	mrna	NN
cord-270469-lle32mha	93	3	containing	contain	VBG
cord-270469-lle32mha	93	4	short	short	JJ
cord-270469-lle32mha	93	5	open	open	JJ
cord-270469-lle32mha	93	6	reading	reading	NN
cord-270469-lle32mha	93	7	frames	frame	NNS
cord-270469-lle32mha	93	8	in	in	IN
cord-270469-lle32mha	93	9	their	-PRON-	PRP$
cord-270469-lle32mha	93	10	5	5	CD
cord-270469-lle32mha	93	11	0	0	CD
cord-270469-lle32mha	93	12	untranslated	untranslated	JJ
cord-270469-lle32mha	93	13	region	region	NN
cord-270469-lle32mha	93	14	are	be	VBP
cord-270469-lle32mha	93	15	induced	induce	VBN
cord-270469-lle32mha	93	16	when	when	WRB
cord-270469-lle32mha	93	17	EIF2a	EIF2a	NNP
cord-270469-lle32mha	93	18	is	be	VBZ
cord-270469-lle32mha	93	19	inhibited	inhibit	VBN
cord-270469-lle32mha	93	20	.	.	.
cord-270469-lle32mha	94	1	EIF2a	EIF2a	NNP
cord-270469-lle32mha	94	2	phosphorylation	phosphorylation	NN
cord-270469-lle32mha	94	3	can	can	MD
cord-270469-lle32mha	94	4	therefore	therefore	RB
cord-270469-lle32mha	94	5	promote	promote	VB
cord-270469-lle32mha	94	6	the	the	DT
cord-270469-lle32mha	94	7	synthesis	synthesis	NN
cord-270469-lle32mha	94	8	of	of	IN
cord-270469-lle32mha	94	9	a	a	DT
cord-270469-lle32mha	94	10	specific	specific	JJ
cord-270469-lle32mha	94	11	subset	subset	NN
cord-270469-lle32mha	94	12	of	of	IN
cord-270469-lle32mha	94	13	genes	gene	NNS
cord-270469-lle32mha	94	14	by	by	IN
cord-270469-lle32mha	94	15	increasing	increase	VBG
cord-270469-lle32mha	94	16	the	the	DT
cord-270469-lle32mha	94	17	translation	translation	NN
cord-270469-lle32mha	94	18	of	of	IN
cord-270469-lle32mha	94	19	selective	selective	JJ
cord-270469-lle32mha	94	20	mRNAs	mRNAs	NNPS
cord-270469-lle32mha	94	21	whose	whose	WP$
cord-270469-lle32mha	94	22	translation	translation	NN
cord-270469-lle32mha	94	23	is	be	VBZ
cord-270469-lle32mha	94	24	inhibited	inhibit	VBN
cord-270469-lle32mha	94	25	in	in	IN
cord-270469-lle32mha	94	26	unstressed	unstressed	JJ
cord-270469-lle32mha	94	27	cells	cell	NNS
cord-270469-lle32mha	94	28	.	.	.
cord-270469-lle32mha	95	1	For	for	IN
cord-270469-lle32mha	95	2	example	example	NN
cord-270469-lle32mha	95	3	this	this	DT
cord-270469-lle32mha	95	4	mechanisms	mechanism	NNS
cord-270469-lle32mha	95	5	promote	promote	VBP
cord-270469-lle32mha	95	6	the	the	DT
cord-270469-lle32mha	95	7	translation	translation	NN
cord-270469-lle32mha	95	8	of	of	IN
cord-270469-lle32mha	95	9	activating	activate	VBG
cord-270469-lle32mha	95	10	transcription	transcription	NN
cord-270469-lle32mha	95	11	factor	factor	NN
cord-270469-lle32mha	95	12	4	4	CD
cord-270469-lle32mha	95	13	(	(	-LRB-
cord-270469-lle32mha	95	14	ATF4	ATF4	NNP
cord-270469-lle32mha	95	15	)	)	-RRB-
cord-270469-lle32mha	96	1	a	a	DT
cord-270469-lle32mha	96	2	major	major	JJ
cord-270469-lle32mha	96	3	regulator	regulator	NN
cord-270469-lle32mha	96	4	of	of	IN
cord-270469-lle32mha	96	5	ER	er	NN
cord-270469-lle32mha	96	6	-	-	HYPH
cord-270469-lle32mha	96	7	stress	stress	NN
cord-270469-lle32mha	96	8	.	.	.
cord-270469-lle32mha	97	1	ATF4	ATF4	NNP
cord-270469-lle32mha	97	2	is	be	VBZ
cord-270469-lle32mha	97	3	involved	involve	VBN
cord-270469-lle32mha	97	4	in	in	IN
cord-270469-lle32mha	97	5	various	various	JJ
cord-270469-lle32mha	97	6	cellular	cellular	JJ
cord-270469-lle32mha	97	7	responses	response	NNS
cord-270469-lle32mha	97	8	including	include	VBG
cord-270469-lle32mha	97	9	,	,	,
cord-270469-lle32mha	97	10	glutathione	glutathione	NN
cord-270469-lle32mha	97	11	biosynthesis	biosynthesis	NN
cord-270469-lle32mha	97	12	,	,	,
cord-270469-lle32mha	97	13	amino	amino	NN
cord-270469-lle32mha	97	14	acid	acid	NN
cord-270469-lle32mha	97	15	import	import	NN
cord-270469-lle32mha	97	16	,	,	,
cord-270469-lle32mha	97	17	and	and	CC
cord-270469-lle32mha	97	18	resistance	resistance	NN
cord-270469-lle32mha	97	19	to	to	IN
cord-270469-lle32mha	97	20	oxidative	oxidative	JJ
cord-270469-lle32mha	97	21	stress	stress	NN
cord-270469-lle32mha	97	22	[	[	-LRB-
cord-270469-lle32mha	97	23	37e39	37e39	CD
cord-270469-lle32mha	97	24	]	]	-RRB-
cord-270469-lle32mha	97	25	.	.	.
cord-270469-lle32mha	98	1	PERK	PERK	NNP
cord-270469-lle32mha	98	2	also	also	RB
cord-270469-lle32mha	98	3	phosphorylates	phosphorylate	VBZ
cord-270469-lle32mha	98	4	Nuclear	Nuclear	NNP
cord-270469-lle32mha	98	5	Factor	Factor	NNP
cord-270469-lle32mha	98	6	(	(	-LRB-
cord-270469-lle32mha	98	7	erythroid	erythroid	NN
cord-270469-lle32mha	98	8	-	-	HYPH
cord-270469-lle32mha	98	9	derived	derive	VBN
cord-270469-lle32mha	98	10	2)-like	2)-like	CD
cord-270469-lle32mha	98	11	2	2	CD
cord-270469-lle32mha	98	12	(	(	-LRB-
cord-270469-lle32mha	98	13	NRF2	NRF2	NNP
cord-270469-lle32mha	98	14	)	)	-RRB-
cord-270469-lle32mha	98	15	,	,	,
cord-270469-lle32mha	98	16	a	a	DT
cord-270469-lle32mha	98	17	transcription	transcription	NN
cord-270469-lle32mha	98	18	factor	factor	NN
cord-270469-lle32mha	98	19	that	that	WDT
cord-270469-lle32mha	98	20	regulates	regulate	VBZ
cord-270469-lle32mha	98	21	oxidative	oxidative	JJ
cord-270469-lle32mha	98	22	stress	stress	NN
cord-270469-lle32mha	98	23	responses	response	NNS
cord-270469-lle32mha	98	24	and	and	CC
cord-270469-lle32mha	98	25	a	a	DT
cord-270469-lle32mha	98	26	critical	critical	JJ
cord-270469-lle32mha	98	27	regulator	regulator	NN
cord-270469-lle32mha	98	28	of	of	IN
cord-270469-lle32mha	98	29	innate	innate	JJ
cord-270469-lle32mha	98	30	immune	immune	JJ
cord-270469-lle32mha	98	31	responses	response	NNS
cord-270469-lle32mha	98	32	[	[	-LRB-
cord-270469-lle32mha	98	33	32	32	CD
cord-270469-lle32mha	98	34	,	,	,
cord-270469-lle32mha	98	35	40	40	CD
cord-270469-lle32mha	98	36	,	,	,
cord-270469-lle32mha	98	37	41	41	CD
cord-270469-lle32mha	98	38	]	]	-RRB-
cord-270469-lle32mha	98	39	.	.	.
cord-270469-lle32mha	99	1	The	the	DT
cord-270469-lle32mha	99	2	third	third	JJ
cord-270469-lle32mha	99	3	branch	branch	NN
cord-270469-lle32mha	99	4	of	of	IN
cord-270469-lle32mha	99	5	the	the	DT
cord-270469-lle32mha	99	6	ER	ER	NNP
cord-270469-lle32mha	99	7	-	-	HYPH
cord-270469-lle32mha	99	8	stress	stress	NN
cord-270469-lle32mha	99	9	pathway	pathway	NN
cord-270469-lle32mha	99	10	is	be	VBZ
cord-270469-lle32mha	99	11	mediated	mediate	VBN
cord-270469-lle32mha	99	12	by	by	IN
cord-270469-lle32mha	99	13	ATF6	ATF6	NNP
cord-270469-lle32mha	99	14	,	,	,
cord-270469-lle32mha	99	15	the	the	DT
cord-270469-lle32mha	99	16	best	well	RBS
cord-270469-lle32mha	99	17	-	-	HYPH
cord-270469-lle32mha	99	18	known	know	VBN
cord-270469-lle32mha	99	19	member	member	NN
cord-270469-lle32mha	99	20	of	of	IN
cord-270469-lle32mha	99	21	a	a	DT
cord-270469-lle32mha	99	22	transmembrane	transmembrane	NN
cord-270469-lle32mha	99	23	protein	protein	NN
cord-270469-lle32mha	99	24	Fig	Fig	NNP
cord-270469-lle32mha	99	25	.	.	.
cord-270469-lle32mha	100	1	2	2	LS
cord-270469-lle32mha	100	2	.	.	.
cord-270469-lle32mha	101	1	ER	er	NN
cord-270469-lle32mha	101	2	-	-	HYPH
cord-270469-lle32mha	101	3	stress	stress	NN
cord-270469-lle32mha	101	4	signaling	signal	VBG
cord-270469-lle32mha	101	5	pathways	pathway	NNS
cord-270469-lle32mha	101	6	.	.	.
cord-270469-lle32mha	102	1	Accumulation	accumulation	NN
cord-270469-lle32mha	102	2	of	of	IN
cord-270469-lle32mha	102	3	unfolded	unfolded	JJ
cord-270469-lle32mha	102	4	proteins	protein	NNS
cord-270469-lle32mha	102	5	or	or	CC
cord-270469-lle32mha	102	6	loss	loss	NN
cord-270469-lle32mha	102	7	of	of	IN
cord-270469-lle32mha	102	8	homeostasis	homeostasis	NN
cord-270469-lle32mha	102	9	in	in	IN
cord-270469-lle32mha	102	10	the	the	DT
cord-270469-lle32mha	102	11	ER	ER	NNP
cord-270469-lle32mha	102	12	triggers	trigger	VBZ
cord-270469-lle32mha	102	13	a	a	DT
cord-270469-lle32mha	102	14	stress	stress	NN
cord-270469-lle32mha	102	15	response	response	NN
cord-270469-lle32mha	102	16	that	that	WDT
cord-270469-lle32mha	102	17	activates	activate	VBZ
cord-270469-lle32mha	102	18	ERsignaling	ersignale	VBG
cord-270469-lle32mha	102	19	pathways	pathway	NNS
cord-270469-lle32mha	102	20	including	include	VBG
cord-270469-lle32mha	102	21	IRE1	IRE1	NNP
cord-270469-lle32mha	102	22	,	,	,
cord-270469-lle32mha	102	23	ATF6	ATF6	NNP
cord-270469-lle32mha	102	24	,	,	,
cord-270469-lle32mha	102	25	and	and	CC
cord-270469-lle32mha	102	26	PERK	perk	VB
cord-270469-lle32mha	102	27	.	.	.
cord-270469-lle32mha	103	1	Active	active	JJ
cord-270469-lle32mha	103	2	IRE1	IRE1	NNP
cord-270469-lle32mha	103	3	lead	lead	NN
cord-270469-lle32mha	103	4	to	to	IN
cord-270469-lle32mha	103	5	an	an	DT
cord-270469-lle32mha	103	6	unconventional	unconventional	JJ
cord-270469-lle32mha	103	7	splicing	splicing	NN
cord-270469-lle32mha	103	8	of	of	IN
cord-270469-lle32mha	103	9	the	the	DT
cord-270469-lle32mha	103	10	transcription	transcription	NN
cord-270469-lle32mha	103	11	factor	factor	NN
cord-270469-lle32mha	103	12	XBP1	XBP1	NNP
cord-270469-lle32mha	103	13	and	and	CC
cord-270469-lle32mha	103	14	the	the	DT
cord-270469-lle32mha	103	15	translation	translation	NN
cord-270469-lle32mha	103	16	of	of	IN
cord-270469-lle32mha	103	17	an	an	DT
cord-270469-lle32mha	103	18	active	active	JJ
cord-270469-lle32mha	103	19	transcription	transcription	NN
cord-270469-lle32mha	103	20	factor	factor	NN
cord-270469-lle32mha	103	21	.	.	.
cord-270469-lle32mha	104	1	IRE1	IRE1	NNP
cord-270469-lle32mha	104	2	can	can	MD
cord-270469-lle32mha	104	3	also	also	RB
cord-270469-lle32mha	104	4	activate	activate	VB
cord-270469-lle32mha	104	5	additional	additional	JJ
cord-270469-lle32mha	104	6	pathways	pathway	NNS
cord-270469-lle32mha	104	7	such	such	JJ
cord-270469-lle32mha	104	8	as	as	IN
cord-270469-lle32mha	104	9	the	the	DT
cord-270469-lle32mha	104	10	degradation	degradation	NN
cord-270469-lle32mha	104	11	of	of	IN
cord-270469-lle32mha	104	12	ER	er	NN
cord-270469-lle32mha	104	13	-	-	HYPH
cord-270469-lle32mha	104	14	related	relate	VBN
cord-270469-lle32mha	104	15	mRNAs	mrnas	RB
cord-270469-lle32mha	104	16	through	through	IN
cord-270469-lle32mha	104	17	a	a	DT
cord-270469-lle32mha	104	18	process	process	NN
cord-270469-lle32mha	104	19	termed	term	VBN
cord-270469-lle32mha	104	20	RIDD	RIDD	NNP
cord-270469-lle32mha	104	21	.	.	.
cord-270469-lle32mha	105	1	PERK	PERK	NNP
cord-270469-lle32mha	105	2	activation	activation	NN
cord-270469-lle32mha	105	3	induces	induce	VBZ
cord-270469-lle32mha	105	4	the	the	DT
cord-270469-lle32mha	105	5	translation	translation	NN
cord-270469-lle32mha	105	6	of	of	IN
cord-270469-lle32mha	105	7	the	the	DT
cord-270469-lle32mha	105	8	transcription	transcription	NN
cord-270469-lle32mha	105	9	factor	factor	NN
cord-270469-lle32mha	105	10	ATF4	ATF4	NNP
cord-270469-lle32mha	105	11	and	and	CC
cord-270469-lle32mha	105	12	dampen	dampen	VB
cord-270469-lle32mha	105	13	the	the	DT
cord-270469-lle32mha	105	14	translation	translation	NN
cord-270469-lle32mha	105	15	initiator	initiator	NN
cord-270469-lle32mha	105	16	factor	factor	NN
cord-270469-lle32mha	105	17	ElF2a	elf2a	NN
cord-270469-lle32mha	105	18	activity	activity	NN
cord-270469-lle32mha	105	19	,	,	,
cord-270469-lle32mha	105	20	leading	lead	VBG
cord-270469-lle32mha	105	21	to	to	IN
cord-270469-lle32mha	105	22	decreased	decrease	VBN
cord-270469-lle32mha	105	23	translation	translation	NN
cord-270469-lle32mha	105	24	and	and	CC
cord-270469-lle32mha	105	25	protein	protein	NN
cord-270469-lle32mha	105	26	synthesis	synthesis	NN
cord-270469-lle32mha	105	27	.	.	.
cord-270469-lle32mha	106	1	PERK	PERK	NNP
cord-270469-lle32mha	106	2	also	also	RB
cord-270469-lle32mha	106	3	promotes	promote	VBZ
cord-270469-lle32mha	106	4	the	the	DT
cord-270469-lle32mha	106	5	activation	activation	NN
cord-270469-lle32mha	106	6	of	of	IN
cord-270469-lle32mha	106	7	the	the	DT
cord-270469-lle32mha	106	8	transcriptional	transcriptional	JJ
cord-270469-lle32mha	106	9	regulator	regulator	NN
cord-270469-lle32mha	106	10	NRF2	NRF2	NNP
cord-270469-lle32mha	106	11	.	.	.
cord-270469-lle32mha	107	1	The	the	DT
cord-270469-lle32mha	107	2	transcriptionally	transcriptionally	RB
cord-270469-lle32mha	107	3	active	active	JJ
cord-270469-lle32mha	107	4	form	form	NN
cord-270469-lle32mha	107	5	of	of	IN
cord-270469-lle32mha	107	6	ATF6	ATF6	NNP
cord-270469-lle32mha	107	7	is	be	VBZ
cord-270469-lle32mha	107	8	produced	produce	VBN
cord-270469-lle32mha	107	9	by	by	IN
cord-270469-lle32mha	107	10	proteolysis	proteolysis	NN
cord-270469-lle32mha	107	11	.	.	.
cord-270469-lle32mha	108	1	When	when	WRB
cord-270469-lle32mha	108	2	these	these	DT
cord-270469-lle32mha	108	3	three	three	CD
cord-270469-lle32mha	108	4	main	main	JJ
cord-270469-lle32mha	108	5	pathways	pathway	NNS
cord-270469-lle32mha	108	6	are	be	VBP
cord-270469-lle32mha	108	7	activated	activate	VBN
cord-270469-lle32mha	108	8	simultaneously	simultaneously	RB
cord-270469-lle32mha	108	9	they	-PRON-	PRP
cord-270469-lle32mha	108	10	orchestrate	orchestrate	VBP
cord-270469-lle32mha	108	11	the	the	DT
cord-270469-lle32mha	108	12	ER	er	NN
cord-270469-lle32mha	108	13	-	-	HYPH
cord-270469-lle32mha	108	14	stress	stress	NN
cord-270469-lle32mha	108	15	response	response	NN
cord-270469-lle32mha	108	16	characterized	characterize	VBN
cord-270469-lle32mha	108	17	by	by	IN
cord-270469-lle32mha	108	18	the	the	DT
cord-270469-lle32mha	108	19	transcriptional	transcriptional	JJ
cord-270469-lle32mha	108	20	induction	induction	NN
cord-270469-lle32mha	108	21	of	of	IN
cord-270469-lle32mha	108	22	genes	gene	NNS
cord-270469-lle32mha	108	23	aimed	aim	VBN
cord-270469-lle32mha	108	24	at	at	IN
cord-270469-lle32mha	108	25	restoring	restore	VBG
cord-270469-lle32mha	108	26	ER	ER	NNP
cord-270469-lle32mha	108	27	homeostasis	homeostasis	NN
cord-270469-lle32mha	108	28	.	.	.
cord-270469-lle32mha	109	1	The	the	DT
cord-270469-lle32mha	109	2	outcome	outcome	NN
cord-270469-lle32mha	109	3	of	of	IN
cord-270469-lle32mha	109	4	the	the	DT
cord-270469-lle32mha	109	5	response	response	NN
cord-270469-lle32mha	109	6	is	be	VBZ
cord-270469-lle32mha	109	7	repair	repair	NN
cord-270469-lle32mha	109	8	or	or	CC
cord-270469-lle32mha	109	9	,	,	,
cord-270469-lle32mha	109	10	if	if	IN
cord-270469-lle32mha	109	11	repair	repair	NN
cord-270469-lle32mha	109	12	fails	fail	VBZ
cord-270469-lle32mha	109	13	,	,	,
cord-270469-lle32mha	109	14	cell	cell	NN
cord-270469-lle32mha	109	15	death	death	NN
cord-270469-lle32mha	109	16	and	and	CC
cord-270469-lle32mha	109	17	apoptosis	apoptosis	NN
cord-270469-lle32mha	109	18	.	.	.
cord-270469-lle32mha	110	1	family	family	NN
cord-270469-lle32mha	110	2	that	that	WDT
cord-270469-lle32mha	110	3	encodes	encode	VBZ
cord-270469-lle32mha	110	4	membrane	membrane	NN
cord-270469-lle32mha	110	5	anchored	anchor	VBD
cord-270469-lle32mha	110	6	bZIP	bzip	CD
cord-270469-lle32mha	110	7	transcription	transcription	NN
cord-270469-lle32mha	110	8	factors	factor	NNS
cord-270469-lle32mha	110	9	.	.	.
cord-270469-lle32mha	111	1	Upon	upon	IN
cord-270469-lle32mha	111	2	ER	er	NN
cord-270469-lle32mha	111	3	-	-	HYPH
cord-270469-lle32mha	111	4	stress	stress	NN
cord-270469-lle32mha	111	5	,	,	,
cord-270469-lle32mha	111	6	ATF6	ATF6	NNP
cord-270469-lle32mha	111	7	translocates	translocate	NNS
cord-270469-lle32mha	111	8	to	to	IN
cord-270469-lle32mha	111	9	the	the	DT
cord-270469-lle32mha	111	10	Golgi	Golgi	NNP
cord-270469-lle32mha	111	11	where	where	WRB
cord-270469-lle32mha	111	12	it	-PRON-	PRP
cord-270469-lle32mha	111	13	is	be	VBZ
cord-270469-lle32mha	111	14	processed	process	VBN
cord-270469-lle32mha	111	15	by	by	IN
cord-270469-lle32mha	111	16	site	site	NN
cord-270469-lle32mha	111	17	1	1	CD
cord-270469-lle32mha	111	18	and	and	CC
cord-270469-lle32mha	111	19	site	site	NN
cord-270469-lle32mha	111	20	2	2	CD
cord-270469-lle32mha	111	21	proteases	protease	NNS
cord-270469-lle32mha	111	22	that	that	WDT
cord-270469-lle32mha	111	23	sequentially	sequentially	RB
cord-270469-lle32mha	111	24	remove	remove	VBP
cord-270469-lle32mha	111	25	the	the	DT
cord-270469-lle32mha	111	26	luminal	luminal	JJ
cord-270469-lle32mha	111	27	domain	domain	NN
cord-270469-lle32mha	111	28	and	and	CC
cord-270469-lle32mha	111	29	the	the	DT
cord-270469-lle32mha	111	30	transmembrane	transmembrane	NN
cord-270469-lle32mha	111	31	anchor	anchor	NN
cord-270469-lle32mha	111	32	.	.	.
cord-270469-lle32mha	112	1	These	these	DT
cord-270469-lle32mha	112	2	cleavages	cleavage	NNS
cord-270469-lle32mha	112	3	release	release	VBP
cord-270469-lle32mha	112	4	the	the	DT
cord-270469-lle32mha	112	5	transcriptionally	transcriptionally	RB
cord-270469-lle32mha	112	6	active	active	JJ
cord-270469-lle32mha	112	7	N	n	CD
cord-270469-lle32mha	112	8	-	-	HYPH
cord-270469-lle32mha	112	9	terminal	terminal	NN
cord-270469-lle32mha	112	10	fragment	fragment	NN
cord-270469-lle32mha	112	11	of	of	IN
cord-270469-lle32mha	112	12	ATF6	ATF6	NNP
cord-270469-lle32mha	112	13	(	(	-LRB-
cord-270469-lle32mha	112	14	ATF6N	atf6n	NN
cord-270469-lle32mha	112	15	)	)	-RRB-
cord-270469-lle32mha	112	16	which	which	WDT
cord-270469-lle32mha	112	17	relocates	relocate	VBZ
cord-270469-lle32mha	112	18	to	to	IN
cord-270469-lle32mha	112	19	nucleus	nucleus	NN
cord-270469-lle32mha	112	20	where	where	WRB
cord-270469-lle32mha	112	21	it	-PRON-	PRP
cord-270469-lle32mha	112	22	upregulates	upregulate	VBZ
cord-270469-lle32mha	112	23	ER	er	NN
cord-270469-lle32mha	112	24	-	-	HYPH
cord-270469-lle32mha	112	25	stress	stress	NN
cord-270469-lle32mha	112	26	induced	induce	VBN
cord-270469-lle32mha	112	27	genes	gene	NNS
cord-270469-lle32mha	112	28	related	relate	VBN
cord-270469-lle32mha	112	29	to	to	IN
cord-270469-lle32mha	112	30	protein	protein	NN
cord-270469-lle32mha	112	31	folding	folding	NN
cord-270469-lle32mha	112	32	and	and	CC
cord-270469-lle32mha	112	33	lipid	lipid	NN
cord-270469-lle32mha	112	34	synthesis	synthesis	NN
cord-270469-lle32mha	112	35	[	[	-LRB-
cord-270469-lle32mha	112	36	34,42e44	34,42e44	CD
cord-270469-lle32mha	112	37	]	]	-RRB-
cord-270469-lle32mha	112	38	.	.	.
cord-270469-lle32mha	113	1	Beyond	beyond	IN
cord-270469-lle32mha	113	2	the	the	DT
cord-270469-lle32mha	113	3	adaptation	adaptation	NN
cord-270469-lle32mha	113	4	phase	phase	NN
cord-270469-lle32mha	113	5	that	that	WDT
cord-270469-lle32mha	113	6	restore	restore	VBP
cord-270469-lle32mha	113	7	ER	ER	NNP
cord-270469-lle32mha	113	8	homeostasis	homeostasis	NN
cord-270469-lle32mha	113	9	,	,	,
cord-270469-lle32mha	113	10	ER	er	NN
cord-270469-lle32mha	113	11	-	-	HYPH
cord-270469-lle32mha	113	12	stress	stress	NN
cord-270469-lle32mha	113	13	as	as	RB
cord-270469-lle32mha	113	14	well	well	RB
cord-270469-lle32mha	113	15	as	as	IN
cord-270469-lle32mha	113	16	the	the	DT
cord-270469-lle32mha	113	17	activation	activation	NN
cord-270469-lle32mha	113	18	of	of	IN
cord-270469-lle32mha	113	19	ER	er	NN
cord-270469-lle32mha	113	20	-	-	HYPH
cord-270469-lle32mha	113	21	signaling	signal	VBG
cord-270469-lle32mha	113	22	pathways	pathway	NNS
cord-270469-lle32mha	113	23	can	can	MD
cord-270469-lle32mha	113	24	impact	impact	VB
cord-270469-lle32mha	113	25	on	on	IN
cord-270469-lle32mha	113	26	host	host	NN
cord-270469-lle32mha	113	27	immune	immune	JJ
cord-270469-lle32mha	113	28	functions	function	NNS
cord-270469-lle32mha	113	29	and	and	CC
cord-270469-lle32mha	113	30	promote	promote	VB
cord-270469-lle32mha	113	31	inflammation	inflammation	NN
cord-270469-lle32mha	113	32	[	[	-LRB-
cord-270469-lle32mha	113	33	9	9	CD
cord-270469-lle32mha	113	34	,	,	,
cord-270469-lle32mha	113	35	45	45	CD
cord-270469-lle32mha	113	36	]	]	-RRB-
cord-270469-lle32mha	113	37	.	.	.
cord-270469-lle32mha	114	1	ER	ER	NNP
cord-270469-lle32mha	114	2	-	-	HYPH
cord-270469-lle32mha	114	3	stress	stress	NN
cord-270469-lle32mha	114	4	observed	observe	VBN
cord-270469-lle32mha	114	5	in	in	IN
cord-270469-lle32mha	114	6	inflammatory	inflammatory	JJ
cord-270469-lle32mha	114	7	pathologies	pathology	NNS
cord-270469-lle32mha	114	8	determine	determine	VBP
cord-270469-lle32mha	114	9	the	the	DT
cord-270469-lle32mha	114	10	size	size	NN
cord-270469-lle32mha	114	11	,	,	,
cord-270469-lle32mha	114	12	nature	nature	NN
cord-270469-lle32mha	114	13	and	and	CC
cord-270469-lle32mha	114	14	duration	duration	NN
cord-270469-lle32mha	114	15	of	of	IN
cord-270469-lle32mha	114	16	immune	immune	JJ
cord-270469-lle32mha	114	17	response	response	NN
cord-270469-lle32mha	114	18	[	[	-LRB-
cord-270469-lle32mha	114	19	1	1	CD
cord-270469-lle32mha	114	20	,	,	,
cord-270469-lle32mha	114	21	3	3	CD
cord-270469-lle32mha	114	22	,	,	,
cord-270469-lle32mha	114	23	46	46	CD
cord-270469-lle32mha	114	24	]	]	-RRB-
cord-270469-lle32mha	114	25	.	.	.
cord-270469-lle32mha	115	1	Several	several	JJ
cord-270469-lle32mha	115	2	studies	study	NNS
cord-270469-lle32mha	115	3	have	have	VBP
cord-270469-lle32mha	115	4	showed	show	VBN
cord-270469-lle32mha	115	5	that	that	IN
cord-270469-lle32mha	115	6	ER	er	NN
cord-270469-lle32mha	115	7	-	-	HYPH
cord-270469-lle32mha	115	8	stress	stress	NN
cord-270469-lle32mha	115	9	might	may	MD
cord-270469-lle32mha	115	10	augment	augment	VB
cord-270469-lle32mha	115	11	inflammation	inflammation	NN
cord-270469-lle32mha	115	12	.	.	.
cord-270469-lle32mha	116	1	Mutations	mutation	NNS
cord-270469-lle32mha	116	2	in	in	IN
cord-270469-lle32mha	116	3	mice	mouse	NNS
cord-270469-lle32mha	116	4	that	that	WDT
cord-270469-lle32mha	116	5	produce	produce	VBP
cord-270469-lle32mha	116	6	defects	defect	NNS
cord-270469-lle32mha	116	7	in	in	IN
cord-270469-lle32mha	116	8	protein	protein	NN
cord-270469-lle32mha	116	9	folding	folding	NN
cord-270469-lle32mha	116	10	or	or	CC
cord-270469-lle32mha	116	11	in	in	IN
cord-270469-lle32mha	116	12	the	the	DT
cord-270469-lle32mha	116	13	ER	er	NN
cord-270469-lle32mha	116	14	-	-	HYPH
cord-270469-lle32mha	116	15	stress	stress	NN
cord-270469-lle32mha	116	16	response	response	NN
cord-270469-lle32mha	116	17	pathways	pathway	NNS
cord-270469-lle32mha	116	18	lead	lead	VBP
cord-270469-lle32mha	116	19	to	to	IN
cord-270469-lle32mha	116	20	spontaneous	spontaneous	JJ
cord-270469-lle32mha	116	21	inflammation	inflammation	NN
cord-270469-lle32mha	116	22	.	.	.
cord-270469-lle32mha	117	1	Mice	mouse	NNS
cord-270469-lle32mha	117	2	with	with	IN
cord-270469-lle32mha	117	3	a	a	DT
cord-270469-lle32mha	117	4	mutation	mutation	NN
cord-270469-lle32mha	117	5	impairing	impair	VBG
cord-270469-lle32mha	117	6	the	the	DT
cord-270469-lle32mha	117	7	folding	folding	NN
cord-270469-lle32mha	117	8	of	of	IN
cord-270469-lle32mha	117	9	MUC2	MUC2	NNP
cord-270469-lle32mha	117	10	,	,	,
cord-270469-lle32mha	117	11	a	a	DT
cord-270469-lle32mha	117	12	mucin	mucin	NN
cord-270469-lle32mha	117	13	expressed	express	VBN
cord-270469-lle32mha	117	14	in	in	IN
cord-270469-lle32mha	117	15	the	the	DT
cord-270469-lle32mha	117	16	Paneth	Paneth	NNP
cord-270469-lle32mha	117	17	and	and	CC
cord-270469-lle32mha	117	18	goblet	goblet	NN
cord-270469-lle32mha	117	19	cells	cell	NNS
cord-270469-lle32mha	117	20	,	,	,
cord-270469-lle32mha	117	21	show	show	VBP
cord-270469-lle32mha	117	22	signs	sign	NNS
cord-270469-lle32mha	117	23	of	of	IN
cord-270469-lle32mha	117	24	ER	er	NN
cord-270469-lle32mha	117	25	-	-	HYPH
cord-270469-lle32mha	117	26	stress	stress	NN
cord-270469-lle32mha	117	27	in	in	IN
cord-270469-lle32mha	117	28	the	the	DT
cord-270469-lle32mha	117	29	intestine	intestine	NN
cord-270469-lle32mha	117	30	and	and	CC
cord-270469-lle32mha	117	31	develop	develop	VB
cord-270469-lle32mha	117	32	an	an	DT
cord-270469-lle32mha	117	33	inflammatory	inflammatory	JJ
cord-270469-lle32mha	117	34	phenotype	phenotype	NN
cord-270469-lle32mha	117	35	similar	similar	JJ
cord-270469-lle32mha	117	36	to	to	IN
cord-270469-lle32mha	117	37	the	the	DT
cord-270469-lle32mha	117	38	inflammation	inflammation	NN
cord-270469-lle32mha	117	39	observed	observe	VBN
cord-270469-lle32mha	117	40	in	in	IN
cord-270469-lle32mha	117	41	inflammatory	inflammatory	JJ
cord-270469-lle32mha	117	42	bowel	bowel	NN
cord-270469-lle32mha	117	43	disease	disease	NN
cord-270469-lle32mha	117	44	(	(	-LRB-
cord-270469-lle32mha	117	45	IBD	IBD	NNP
cord-270469-lle32mha	117	46	)	)	-RRB-
cord-270469-lle32mha	117	47	patients	patient	NNS
cord-270469-lle32mha	117	48	[	[	-LRB-
cord-270469-lle32mha	117	49	4	4	CD
cord-270469-lle32mha	117	50	,	,	,
cord-270469-lle32mha	117	51	47	47	CD
cord-270469-lle32mha	117	52	]	]	-RRB-
cord-270469-lle32mha	117	53	.	.	.
cord-270469-lle32mha	118	1	Patients	patient	NNS
cord-270469-lle32mha	118	2	that	that	WDT
cord-270469-lle32mha	118	3	carry	carry	VBP
cord-270469-lle32mha	118	4	misfolding	misfolding	NN
cord-270469-lle32mha	118	5	mutations	mutation	NNS
cord-270469-lle32mha	118	6	in	in	IN
cord-270469-lle32mha	118	7	the	the	DT
cord-270469-lle32mha	118	8	surfactant	surfactant	NN
cord-270469-lle32mha	118	9	protein	protein	NN
cord-270469-lle32mha	118	10	-	-	HYPH
cord-270469-lle32mha	118	11	C	C	NNP
cord-270469-lle32mha	118	12	(	(	-LRB-
cord-270469-lle32mha	118	13	SFTPC	SFTPC	NNP
cord-270469-lle32mha	118	14	)	)	-RRB-
cord-270469-lle32mha	118	15	gene	gene	NN
cord-270469-lle32mha	118	16	are	be	VBP
cord-270469-lle32mha	118	17	characterized	characterize	VBN
cord-270469-lle32mha	118	18	by	by	IN
cord-270469-lle32mha	118	19	ER	ER	NNP
cord-270469-lle32mha	118	20	-	-	HYPH
cord-270469-lle32mha	118	21	stress	stress	NN
cord-270469-lle32mha	118	22	activation	activation	NN
cord-270469-lle32mha	118	23	in	in	IN
cord-270469-lle32mha	118	24	epithelial	epithelial	JJ
cord-270469-lle32mha	118	25	cells	cell	NNS
cord-270469-lle32mha	118	26	and	and	CC
cord-270469-lle32mha	118	27	develop	develop	VB
cord-270469-lle32mha	118	28	hyper	hyper	JJ
cord-270469-lle32mha	118	29	-	-	JJ
cord-270469-lle32mha	118	30	inflammatory	inflammatory	JJ
cord-270469-lle32mha	118	31	responses	response	NNS
cord-270469-lle32mha	118	32	upon	upon	IN
cord-270469-lle32mha	118	33	viral	viral	JJ
cord-270469-lle32mha	118	34	infections	infection	NNS
cord-270469-lle32mha	118	35	[	[	-LRB-
cord-270469-lle32mha	118	36	6	6	CD
cord-270469-lle32mha	118	37	,	,	,
cord-270469-lle32mha	118	38	48	48	CD
cord-270469-lle32mha	118	39	]	]	-RRB-
cord-270469-lle32mha	118	40	.	.	.
cord-270469-lle32mha	119	1	Viruses	virus	NNS
cord-270469-lle32mha	119	2	are	be	VBP
cord-270469-lle32mha	119	3	believed	believe	VBN
cord-270469-lle32mha	119	4	to	to	TO
cord-270469-lle32mha	119	5	contribute	contribute	VB
cord-270469-lle32mha	119	6	to	to	IN
cord-270469-lle32mha	119	7	the	the	DT
cord-270469-lle32mha	119	8	onset	onset	NN
cord-270469-lle32mha	119	9	of	of	IN
cord-270469-lle32mha	119	10	idiopathic	idiopathic	JJ
cord-270469-lle32mha	119	11	pulmonary	pulmonary	JJ
cord-270469-lle32mha	119	12	fibrosis	fibrosis	NN
cord-270469-lle32mha	119	13	(	(	-LRB-
cord-270469-lle32mha	119	14	IPF	IPF	NNP
cord-270469-lle32mha	119	15	)	)	-RRB-
cord-270469-lle32mha	119	16	in	in	IN
cord-270469-lle32mha	119	17	these	these	DT
cord-270469-lle32mha	119	18	patients	patient	NNS
cord-270469-lle32mha	119	19	.	.	.
cord-270469-lle32mha	120	1	However	however	RB
cord-270469-lle32mha	120	2	the	the	DT
cord-270469-lle32mha	120	3	exact	exact	JJ
cord-270469-lle32mha	120	4	contribution	contribution	NN
cord-270469-lle32mha	120	5	of	of	IN
cord-270469-lle32mha	120	6	the	the	DT
cord-270469-lle32mha	120	7	infection	infection	NN
cord-270469-lle32mha	120	8	in	in	IN
cord-270469-lle32mha	120	9	the	the	DT
cord-270469-lle32mha	120	10	induction	induction	NN
cord-270469-lle32mha	120	11	of	of	IN
cord-270469-lle32mha	120	12	ER	er	NN
cord-270469-lle32mha	120	13	-	-	HYPH
cord-270469-lle32mha	120	14	stress	stress	NN
cord-270469-lle32mha	120	15	or	or	CC
cord-270469-lle32mha	120	16	the	the	DT
cord-270469-lle32mha	120	17	contribution	contribution	NN
cord-270469-lle32mha	120	18	of	of	IN
cord-270469-lle32mha	120	19	ER	er	NN
cord-270469-lle32mha	120	20	-	-	HYPH
cord-270469-lle32mha	120	21	stress	stress	NN
cord-270469-lle32mha	120	22	to	to	IN
cord-270469-lle32mha	120	23	the	the	DT
cord-270469-lle32mha	120	24	upregulation	upregulation	NN
cord-270469-lle32mha	120	25	of	of	IN
cord-270469-lle32mha	120	26	inflammation	inflammation	NN
cord-270469-lle32mha	120	27	-	-	HYPH
cord-270469-lle32mha	120	28	mediated	mediate	VBN
cord-270469-lle32mha	120	29	lung	lung	NN
cord-270469-lle32mha	120	30	fibrosis	fibrosis	NN
cord-270469-lle32mha	120	31	in	in	IN
cord-270469-lle32mha	120	32	these	these	DT
cord-270469-lle32mha	120	33	patients	patient	NNS
cord-270469-lle32mha	120	34	are	be	VBP
cord-270469-lle32mha	120	35	still	still	RB
cord-270469-lle32mha	120	36	open	open	JJ
cord-270469-lle32mha	120	37	questions	question	NNS
cord-270469-lle32mha	120	38	.	.	.
cord-270469-lle32mha	121	1	Similarly	similarly	RB
cord-270469-lle32mha	121	2	mutations	mutation	NNS
cord-270469-lle32mha	121	3	in	in	IN
cord-270469-lle32mha	121	4	the	the	DT
cord-270469-lle32mha	121	5	cystic	cystic	JJ
cord-270469-lle32mha	121	6	fibrosis	fibrosis	NN
cord-270469-lle32mha	121	7	transmembrane	transmembrane	NNP
cord-270469-lle32mha	121	8	conductance	conductance	NN
cord-270469-lle32mha	121	9	regulator	regulator	NN
cord-270469-lle32mha	121	10	(	(	-LRB-
cord-270469-lle32mha	121	11	CFTR	CFTR	NNP
cord-270469-lle32mha	121	12	)	)	-RRB-
cord-270469-lle32mha	121	13	,	,	,
cord-270469-lle32mha	121	14	an	an	DT
cord-270469-lle32mha	121	15	ion	ion	NN
cord-270469-lle32mha	121	16	transporter	transporter	NN
cord-270469-lle32mha	121	17	,	,	,
cord-270469-lle32mha	121	18	may	may	MD
cord-270469-lle32mha	121	19	cause	cause	VB
cord-270469-lle32mha	121	20	ER	ER	NNP
cord-270469-lle32mha	121	21	-	-	HYPH
cord-270469-lle32mha	121	22	stress	stress	NN
cord-270469-lle32mha	121	23	in	in	IN
cord-270469-lle32mha	121	24	bronchial	bronchial	JJ
cord-270469-lle32mha	121	25	epithelia	epithelium	NNS
cord-270469-lle32mha	121	26	cells	cell	NNS
cord-270469-lle32mha	121	27	that	that	WDT
cord-270469-lle32mha	121	28	become	become	VBP
cord-270469-lle32mha	121	29	hyper	hyper	JJ
cord-270469-lle32mha	121	30	-	-	JJ
cord-270469-lle32mha	121	31	responsive	responsive	JJ
cord-270469-lle32mha	121	32	and	and	CC
cord-270469-lle32mha	121	33	more	more	RBR
cord-270469-lle32mha	121	34	susceptible	susceptible	JJ
cord-270469-lle32mha	121	35	to	to	IN
cord-270469-lle32mha	121	36	respiratory	respiratory	JJ
cord-270469-lle32mha	121	37	infection	infection	NN
cord-270469-lle32mha	121	38	.	.	.
cord-270469-lle32mha	122	1	Hyper	Hyper	NNS
cord-270469-lle32mha	122	2	-	-	NNS
cord-270469-lle32mha	122	3	responses	response	NNS
cord-270469-lle32mha	122	4	to	to	IN
cord-270469-lle32mha	122	5	inflammatory	inflammatory	JJ
cord-270469-lle32mha	122	6	stimuli	stimulus	NNS
cord-270469-lle32mha	122	7	have	have	VBP
cord-270469-lle32mha	122	8	also	also	RB
cord-270469-lle32mha	122	9	been	be	VBN
cord-270469-lle32mha	122	10	shown	show	VBN
cord-270469-lle32mha	122	11	in	in	IN
cord-270469-lle32mha	122	12	macrophages	macrophage	NNS
cord-270469-lle32mha	122	13	.	.	.
cord-270469-lle32mha	123	1	Studies	study	NNS
cord-270469-lle32mha	123	2	showed	show	VBD
cord-270469-lle32mha	123	3	that	that	IN
cord-270469-lle32mha	123	4	HLA	HLA	NNP
cord-270469-lle32mha	123	5	-	-	HYPH
cord-270469-lle32mha	123	6	B27	B27	NNP
cord-270469-lle32mha	123	7	misfolding	misfolding	NN
cord-270469-lle32mha	123	8	can	can	MD
cord-270469-lle32mha	123	9	induce	induce	VB
cord-270469-lle32mha	123	10	ER	ER	NNP
cord-270469-lle32mha	123	11	-	-	HYPH
cord-270469-lle32mha	123	12	stress	stress	NN
cord-270469-lle32mha	123	13	responses	response	NNS
cord-270469-lle32mha	123	14	in	in	IN
cord-270469-lle32mha	123	15	macrophages	macrophage	NNS
cord-270469-lle32mha	123	16	resulting	result	VBG
cord-270469-lle32mha	123	17	in	in	IN
cord-270469-lle32mha	123	18	enhanced	enhanced	JJ
cord-270469-lle32mha	123	19	cytokine	cytokine	NN
cord-270469-lle32mha	123	20	production	production	NN
cord-270469-lle32mha	123	21	and	and	CC
cord-270469-lle32mha	123	22	increased	increase	VBN
cord-270469-lle32mha	123	23	release	release	NN
cord-270469-lle32mha	123	24	of	of	IN
cord-270469-lle32mha	123	25	type	type	NN
cord-270469-lle32mha	124	1	I	-PRON-	PRP
cord-270469-lle32mha	124	2	interferon	interferon	VBD
cord-270469-lle32mha	124	3	,	,	,
cord-270469-lle32mha	124	4	upon	upon	IN
cord-270469-lle32mha	124	5	stimulation	stimulation	NN
cord-270469-lle32mha	124	6	with	with	IN
cord-270469-lle32mha	124	7	the	the	DT
cord-270469-lle32mha	124	8	TLR4	TLR4	NNP
cord-270469-lle32mha	124	9	agonist	agonist	NN
cord-270469-lle32mha	124	10	LPS	lp	NNS
cord-270469-lle32mha	124	11	.	.	.
cord-270469-lle32mha	125	1	HLA	HLA	NNP
cord-270469-lle32mha	125	2	-	-	HYPH
cord-270469-lle32mha	125	3	B27	B27	NNP
cord-270469-lle32mha	125	4	misfolding	misfolding	NN
cord-270469-lle32mha	125	5	is	be	VBZ
cord-270469-lle32mha	125	6	associated	associate	VBN
cord-270469-lle32mha	125	7	with	with	IN
cord-270469-lle32mha	125	8	susceptibility	susceptibility	NN
cord-270469-lle32mha	125	9	to	to	IN
cord-270469-lle32mha	125	10	spondyloarthritides	spondyloarthritides	NNP
cord-270469-lle32mha	125	11	,	,	,
cord-270469-lle32mha	125	12	a	a	DT
cord-270469-lle32mha	125	13	group	group	NN
cord-270469-lle32mha	125	14	of	of	IN
cord-270469-lle32mha	125	15	heterogeneous	heterogeneous	JJ
cord-270469-lle32mha	125	16	autoinflammatory	autoinflammatory	JJ
cord-270469-lle32mha	125	17	diseases	disease	NNS
cord-270469-lle32mha	125	18	[	[	-LRB-
cord-270469-lle32mha	125	19	8	8	CD
cord-270469-lle32mha	125	20	,	,	,
cord-270469-lle32mha	125	21	49	49	CD
cord-270469-lle32mha	125	22	]	]	-RRB-
cord-270469-lle32mha	125	23	.	.	.
cord-270469-lle32mha	126	1	In	in	IN
cord-270469-lle32mha	126	2	an	an	DT
cord-270469-lle32mha	126	3	other	other	JJ
cord-270469-lle32mha	126	4	autoinflammatory	autoinflammatory	JJ
cord-270469-lle32mha	126	5	disease	disease	NN
cord-270469-lle32mha	126	6	,	,	,
cord-270469-lle32mha	126	7	ER	er	NN
cord-270469-lle32mha	126	8	-	-	HYPH
cord-270469-lle32mha	126	9	retention	retention	NN
cord-270469-lle32mha	126	10	of	of	IN
cord-270469-lle32mha	126	11	the	the	DT
cord-270469-lle32mha	126	12	TNF	TNF	NNP
cord-270469-lle32mha	126	13	receptor	receptor	NN
cord-270469-lle32mha	126	14	(	(	-LRB-
cord-270469-lle32mha	126	15	TNFR1	TNFR1	NNP
cord-270469-lle32mha	126	16	)	)	-RRB-
cord-270469-lle32mha	126	17	was	be	VBD
cord-270469-lle32mha	126	18	shown	show	VBN
cord-270469-lle32mha	126	19	to	to	TO
cord-270469-lle32mha	126	20	contribute	contribute	VB
cord-270469-lle32mha	126	21	to	to	IN
cord-270469-lle32mha	126	22	increased	increase	VBN
cord-270469-lle32mha	126	23	cytokines	cytokine	NNS
cord-270469-lle32mha	126	24	production	production	NN
cord-270469-lle32mha	126	25	observed	observe	VBN
cord-270469-lle32mha	126	26	in	in	IN
cord-270469-lle32mha	126	27	TNFR1-associated	TNFR1-associated	NNP
cord-270469-lle32mha	126	28	periodic	periodic	JJ
cord-270469-lle32mha	126	29	syndrome	syndrome	NN
cord-270469-lle32mha	126	30	(	(	-LRB-
cord-270469-lle32mha	126	31	TRAPS	trap	NNS
cord-270469-lle32mha	126	32	)	)	-RRB-
cord-270469-lle32mha	126	33	patients	patient	NNS
cord-270469-lle32mha	126	34	[	[	-LRB-
cord-270469-lle32mha	126	35	10	10	CD
cord-270469-lle32mha	126	36	]	]	-RRB-
cord-270469-lle32mha	126	37	,	,	,
cord-270469-lle32mha	126	38	suggesting	suggest	VBG
cord-270469-lle32mha	126	39	that	that	IN
cord-270469-lle32mha	126	40	perturbations	perturbation	NNS
cord-270469-lle32mha	126	41	in	in	IN
cord-270469-lle32mha	126	42	the	the	DT
cord-270469-lle32mha	126	43	ER	ER	NNP
cord-270469-lle32mha	126	44	could	could	MD
cord-270469-lle32mha	126	45	be	be	VB
cord-270469-lle32mha	126	46	directly	directly	RB
cord-270469-lle32mha	126	47	linked	link	VBN
cord-270469-lle32mha	126	48	to	to	IN
cord-270469-lle32mha	126	49	the	the	DT
cord-270469-lle32mha	126	50	development	development	NN
cord-270469-lle32mha	126	51	of	of	IN
cord-270469-lle32mha	126	52	autoinflammatory	autoinflammatory	NNP
cord-270469-lle32mha	126	53	syndromes	syndrome	NNS
cord-270469-lle32mha	126	54	.	.	.
cord-270469-lle32mha	127	1	Most	Most	JJS
cord-270469-lle32mha	127	2	autoinflammatory	autoinflammatory	JJ
cord-270469-lle32mha	127	3	diseases	disease	NNS
cord-270469-lle32mha	127	4	have	have	VBP
cord-270469-lle32mha	127	5	been	be	VBN
cord-270469-lle32mha	127	6	associated	associate	VBN
cord-270469-lle32mha	127	7	with	with	IN
cord-270469-lle32mha	127	8	aberrant	aberrant	JJ
cord-270469-lle32mha	127	9	inflammasome	inflammasome	NN
cord-270469-lle32mha	127	10	activation	activation	NN
cord-270469-lle32mha	127	11	[	[	-LRB-
cord-270469-lle32mha	127	12	12	12	CD
cord-270469-lle32mha	127	13	]	]	-RRB-
cord-270469-lle32mha	127	14	.	.	.
cord-270469-lle32mha	128	1	The	the	DT
cord-270469-lle32mha	128	2	inflammasome	inflammasome	NN
cord-270469-lle32mha	128	3	is	be	VBZ
cord-270469-lle32mha	128	4	a	a	DT
cord-270469-lle32mha	128	5	cytosolic	cytosolic	JJ
cord-270469-lle32mha	128	6	multiprotein	multiprotein	NN
cord-270469-lle32mha	128	7	complex	complex	NN
cord-270469-lle32mha	128	8	that	that	WDT
cord-270469-lle32mha	128	9	senses	sense	VBZ
cord-270469-lle32mha	128	10	pathogens	pathogen	NNS
cord-270469-lle32mha	128	11	and	and	CC
cord-270469-lle32mha	128	12	cellular	cellular	JJ
cord-270469-lle32mha	128	13	damage	damage	NN
cord-270469-lle32mha	128	14	and	and	CC
cord-270469-lle32mha	128	15	leads	lead	VBZ
cord-270469-lle32mha	128	16	to	to	IN
cord-270469-lle32mha	128	17	the	the	DT
cord-270469-lle32mha	128	18	activation	activation	NN
cord-270469-lle32mha	128	19	of	of	IN
cord-270469-lle32mha	128	20	a	a	DT
cord-270469-lle32mha	128	21	central	central	JJ
cord-270469-lle32mha	128	22	proteolytic	proteolytic	JJ
cord-270469-lle32mha	128	23	enzyme	enzyme	NN
cord-270469-lle32mha	128	24	,	,	,
cord-270469-lle32mha	128	25	caspase-1	caspase-1	NNP
cord-270469-lle32mha	128	26	.	.	.
cord-270469-lle32mha	129	1	The	the	DT
cord-270469-lle32mha	129	2	main	main	JJ
cord-270469-lle32mha	129	3	function	function	NN
cord-270469-lle32mha	129	4	of	of	IN
cord-270469-lle32mha	129	5	the	the	DT
cord-270469-lle32mha	129	6	inflammasome	inflammasome	NN
cord-270469-lle32mha	129	7	is	be	VBZ
cord-270469-lle32mha	129	8	the	the	DT
cord-270469-lle32mha	129	9	cleavage	cleavage	NN
cord-270469-lle32mha	129	10	and	and	CC
cord-270469-lle32mha	129	11	maturation	maturation	NN
cord-270469-lle32mha	129	12	of	of	IN
cord-270469-lle32mha	129	13	a	a	DT
cord-270469-lle32mha	129	14	few	few	JJ
cord-270469-lle32mha	129	15	key	key	JJ
cord-270469-lle32mha	129	16	cytokines	cytokine	NNS
cord-270469-lle32mha	129	17	,	,	,
cord-270469-lle32mha	129	18	including	include	VBG
cord-270469-lle32mha	129	19	IL-1b	IL-1b	NNS
cord-270469-lle32mha	129	20	.	.	.
cord-270469-lle32mha	130	1	These	these	DT
cord-270469-lle32mha	130	2	cytokines	cytokine	NNS
cord-270469-lle32mha	130	3	drive	drive	VBP
cord-270469-lle32mha	130	4	the	the	DT
cord-270469-lle32mha	130	5	initiation	initiation	NN
cord-270469-lle32mha	130	6	of	of	IN
cord-270469-lle32mha	130	7	inflammatory	inflammatory	JJ
cord-270469-lle32mha	130	8	cascades	cascade	NNS
cord-270469-lle32mha	130	9	in	in	IN
cord-270469-lle32mha	130	10	patients	patient	NNS
cord-270469-lle32mha	130	11	.	.	.
cord-270469-lle32mha	131	1	Because	because	IN
cord-270469-lle32mha	131	2	the	the	DT
cord-270469-lle32mha	131	3	inflammasome	inflammasome	NN
cord-270469-lle32mha	131	4	has	have	VBZ
cord-270469-lle32mha	131	5	been	be	VBN
cord-270469-lle32mha	131	6	shown	show	VBN
cord-270469-lle32mha	131	7	to	to	TO
cord-270469-lle32mha	131	8	become	become	VB
cord-270469-lle32mha	131	9	activated	activate	VBN
cord-270469-lle32mha	131	10	upon	upon	IN
cord-270469-lle32mha	131	11	ER	er	NN
cord-270469-lle32mha	131	12	-	-	HYPH
cord-270469-lle32mha	131	13	stress	stress	NN
cord-270469-lle32mha	131	14	[	[	-LRB-
cord-270469-lle32mha	131	15	14	14	CD
cord-270469-lle32mha	131	16	]	]	-RRB-
cord-270469-lle32mha	131	17	,	,	,
cord-270469-lle32mha	131	18	it	-PRON-	PRP
cord-270469-lle32mha	131	19	is	be	VBZ
cord-270469-lle32mha	131	20	possible	possible	JJ
cord-270469-lle32mha	131	21	that	that	DT
cord-270469-lle32mha	131	22	loss	loss	NN
cord-270469-lle32mha	131	23	of	of	IN
cord-270469-lle32mha	131	24	ER	er	NN
cord-270469-lle32mha	131	25	-	-	HYPH
cord-270469-lle32mha	131	26	homeostasis	homeostasis	NN
cord-270469-lle32mha	131	27	could	could	MD
cord-270469-lle32mha	131	28	directly	directly	RB
cord-270469-lle32mha	131	29	drive	drive	VB
cord-270469-lle32mha	131	30	IL-1b	IL-1b	NNP
cord-270469-lle32mha	131	31	dependent	dependent	JJ
cord-270469-lle32mha	131	32	inflammation	inflammation	NN
cord-270469-lle32mha	131	33	and	and	CC
cord-270469-lle32mha	131	34	contribute	contribute	VB
cord-270469-lle32mha	131	35	to	to	IN
cord-270469-lle32mha	131	36	the	the	DT
cord-270469-lle32mha	131	37	pathogenesis	pathogenesis	NN
cord-270469-lle32mha	131	38	of	of	IN
cord-270469-lle32mha	131	39	diseases	disease	NNS
cord-270469-lle32mha	131	40	including	include	VBG
cord-270469-lle32mha	131	41	autoinflammatory	autoinflammatory	JJ
cord-270469-lle32mha	131	42	syndromes	syndrome	NNS
cord-270469-lle32mha	131	43	such	such	JJ
cord-270469-lle32mha	131	44	as	as	IN
cord-270469-lle32mha	131	45	TRAPS	trap	NNS
cord-270469-lle32mha	131	46	,	,	,
cord-270469-lle32mha	131	47	by	by	IN
cord-270469-lle32mha	131	48	directly	directly	RB
cord-270469-lle32mha	131	49	driving	drive	VBG
cord-270469-lle32mha	131	50	inflammasome	inflammasome	NN
cord-270469-lle32mha	131	51	activation	activation	NN
cord-270469-lle32mha	131	52	.	.	.
cord-270469-lle32mha	132	1	ER	er	NN
cord-270469-lle32mha	132	2	-	-	HYPH
cord-270469-lle32mha	132	3	stress	stress	NN
cord-270469-lle32mha	132	4	is	be	VBZ
cord-270469-lle32mha	132	5	also	also	RB
cord-270469-lle32mha	132	6	involved	involve	VBN
cord-270469-lle32mha	132	7	in	in	IN
cord-270469-lle32mha	132	8	regulating	regulate	VBG
cord-270469-lle32mha	132	9	another	another	DT
cord-270469-lle32mha	132	10	important	important	JJ
cord-270469-lle32mha	132	11	branch	branch	NN
cord-270469-lle32mha	132	12	of	of	IN
cord-270469-lle32mha	132	13	the	the	DT
cord-270469-lle32mha	132	14	innate	innate	JJ
cord-270469-lle32mha	132	15	immune	immune	JJ
cord-270469-lle32mha	132	16	system	system	NN
cord-270469-lle32mha	132	17	:	:	:
cord-270469-lle32mha	133	1	The	the	DT
cord-270469-lle32mha	133	2	Toll	Toll	NNP
cord-270469-lle32mha	133	3	-	-	HYPH
cord-270469-lle32mha	133	4	like	like	JJ
cord-270469-lle32mha	133	5	receptors	receptor	NNS
cord-270469-lle32mha	133	6	(	(	-LRB-
cord-270469-lle32mha	133	7	TLRs	TLRs	NNP
cord-270469-lle32mha	133	8	)	)	-RRB-
cord-270469-lle32mha	133	9	response	response	NN
cord-270469-lle32mha	133	10	.	.	.
cord-270469-lle32mha	134	1	TLRs	TLRs	NNP
cord-270469-lle32mha	134	2	are	be	VBP
cord-270469-lle32mha	134	3	type	type	NN
cord-270469-lle32mha	134	4	I	-PRON-	PRP
cord-270469-lle32mha	134	5	transmembrane	transmembrane	NN
cord-270469-lle32mha	134	6	proteins	protein	NNS
cord-270469-lle32mha	134	7	characterized	characterize	VBN
cord-270469-lle32mha	134	8	by	by	IN
cord-270469-lle32mha	134	9	an	an	DT
cord-270469-lle32mha	134	10	extracellular	extracellular	JJ
cord-270469-lle32mha	134	11	leucine	leucine	NN
cord-270469-lle32mha	134	12	-	-	HYPH
cord-270469-lle32mha	134	13	rich	rich	JJ
cord-270469-lle32mha	134	14	domain	domain	NN
cord-270469-lle32mha	134	15	and	and	CC
cord-270469-lle32mha	134	16	a	a	DT
cord-270469-lle32mha	134	17	cytoplasmic	cytoplasmic	JJ
cord-270469-lle32mha	134	18	domain	domain	NN
cord-270469-lle32mha	134	19	harboring	harbor	VBG
cord-270469-lle32mha	134	20	a	a	DT
cord-270469-lle32mha	134	21	TIR	TIR	NNP
cord-270469-lle32mha	134	22	domain	domain	NN
cord-270469-lle32mha	134	23	similar	similar	JJ
cord-270469-lle32mha	134	24	to	to	IN
cord-270469-lle32mha	134	25	the	the	DT
cord-270469-lle32mha	134	26	cytoplasmic	cytoplasmic	JJ
cord-270469-lle32mha	134	27	domain	domain	NN
cord-270469-lle32mha	134	28	of	of	IN
cord-270469-lle32mha	134	29	the	the	DT
cord-270469-lle32mha	134	30	mammalian	mammalian	JJ
cord-270469-lle32mha	134	31	interleukin	interleukin	NN
cord-270469-lle32mha	134	32	1	1	CD
cord-270469-lle32mha	134	33	receptor	receptor	NN
cord-270469-lle32mha	134	34	(	(	-LRB-
cord-270469-lle32mha	134	35	IL-1R	il-1r	CD
cord-270469-lle32mha	134	36	)	)	-RRB-
cord-270469-lle32mha	134	37	.	.	.
cord-270469-lle32mha	135	1	TLRs	TLRs	NNP
cord-270469-lle32mha	135	2	activation	activation	NN
cord-270469-lle32mha	135	3	upon	upon	IN
cord-270469-lle32mha	135	4	recognition	recognition	NN
cord-270469-lle32mha	135	5	of	of	IN
cord-270469-lle32mha	135	6	"	"	``
cord-270469-lle32mha	135	7	Pathogen	Pathogen	NNP
cord-270469-lle32mha	135	8	-	-	HYPH
cord-270469-lle32mha	135	9	Associated	Associated	NNP
cord-270469-lle32mha	135	10	Molecular	Molecular	NNP
cord-270469-lle32mha	135	11	Patterns	Patterns	NNPS
cord-270469-lle32mha	135	12	"	"	''
cord-270469-lle32mha	135	13	or	or	CC
cord-270469-lle32mha	135	14	PAMPs	pamp	NNS
cord-270469-lle32mha	135	15	,	,	,
cord-270469-lle32mha	135	16	results	result	NNS
cord-270469-lle32mha	135	17	in	in	IN
cord-270469-lle32mha	135	18	initiation	initiation	NN
cord-270469-lle32mha	135	19	of	of	IN
cord-270469-lle32mha	135	20	cellular	cellular	JJ
cord-270469-lle32mha	135	21	signaling	signal	VBG
cord-270469-lle32mha	135	22	events	event	NNS
cord-270469-lle32mha	135	23	including	include	VBG
cord-270469-lle32mha	135	24	activation	activation	NN
cord-270469-lle32mha	135	25	of	of	IN
cord-270469-lle32mha	135	26	transcription	transcription	NN
cord-270469-lle32mha	135	27	factors	factor	NNS
cord-270469-lle32mha	135	28	,	,	,
cord-270469-lle32mha	135	29	cytokine	cytokine	NN
cord-270469-lle32mha	135	30	modulation	modulation	NN
cord-270469-lle32mha	135	31	,	,	,
cord-270469-lle32mha	135	32	and	and	CC
cord-270469-lle32mha	135	33	upregulation	upregulation	NN
cord-270469-lle32mha	135	34	of	of	IN
cord-270469-lle32mha	135	35	interferonstimulated	interferonstimulate	VBN
cord-270469-lle32mha	135	36	genes	gene	NNS
cord-270469-lle32mha	135	37	,	,	,
cord-270469-lle32mha	135	38	leading	lead	VBG
cord-270469-lle32mha	135	39	to	to	IN
cord-270469-lle32mha	135	40	inflammatory	inflammatory	JJ
cord-270469-lle32mha	135	41	responses	response	NNS
cord-270469-lle32mha	135	42	and	and	CC
cord-270469-lle32mha	135	43	the	the	DT
cord-270469-lle32mha	135	44	release	release	NN
cord-270469-lle32mha	135	45	of	of	IN
cord-270469-lle32mha	135	46	antimicrobial	antimicrobial	JJ
cord-270469-lle32mha	135	47	molecules	molecule	NNS
cord-270469-lle32mha	135	48	.	.	.
cord-270469-lle32mha	136	1	Regulatory	regulatory	JJ
cord-270469-lle32mha	136	2	loops	loop	NNS
cord-270469-lle32mha	136	3	connecting	connect	VBG
cord-270469-lle32mha	136	4	TLRs	tlr	NNS
cord-270469-lle32mha	136	5	and	and	CC
cord-270469-lle32mha	136	6	ER	er	NN
cord-270469-lle32mha	136	7	-	-	HYPH
cord-270469-lle32mha	136	8	signaling	signal	VBG
cord-270469-lle32mha	136	9	have	have	VBP
cord-270469-lle32mha	136	10	been	be	VBN
cord-270469-lle32mha	136	11	described	describe	VBN
cord-270469-lle32mha	136	12	.	.	.
cord-270469-lle32mha	137	1	For	for	IN
cord-270469-lle32mha	137	2	example	example	NN
cord-270469-lle32mha	137	3	,	,	,
cord-270469-lle32mha	137	4	TLR4	TLR4	NNP
cord-270469-lle32mha	137	5	and	and	CC
cord-270469-lle32mha	137	6	TLR2	TLR2	NNP
cord-270469-lle32mha	137	7	promote	promote	VBP
cord-270469-lle32mha	137	8	the	the	DT
cord-270469-lle32mha	137	9	mRNA	mRNA	NNP
cord-270469-lle32mha	137	10	maturation	maturation	NN
cord-270469-lle32mha	137	11	of	of	IN
cord-270469-lle32mha	137	12	XBP1s	XBP1s	NNP
cord-270469-lle32mha	137	13	by	by	IN
cord-270469-lle32mha	137	14	selectively	selectively	RB
cord-270469-lle32mha	137	15	triggering	trigger	VBG
cord-270469-lle32mha	137	16	the	the	DT
cord-270469-lle32mha	137	17	IRE1	IRE1	NNP
cord-270469-lle32mha	137	18	branch	branch	NN
cord-270469-lle32mha	137	19	of	of	IN
cord-270469-lle32mha	137	20	the	the	DT
cord-270469-lle32mha	137	21	ER	ER	NNP
cord-270469-lle32mha	137	22	-	-	HYPH
cord-270469-lle32mha	137	23	stress	stress	NN
cord-270469-lle32mha	137	24	response	response	NN
cord-270469-lle32mha	137	25	while	while	IN
cord-270469-lle32mha	137	26	inhibiting	inhibit	VBG
cord-270469-lle32mha	137	27	the	the	DT
cord-270469-lle32mha	137	28	other	other	JJ
cord-270469-lle32mha	137	29	branches	branch	NNS
cord-270469-lle32mha	137	30	of	of	IN
cord-270469-lle32mha	137	31	the	the	DT
cord-270469-lle32mha	137	32	ER	ER	NNP
cord-270469-lle32mha	137	33	-	-	HYPH
cord-270469-lle32mha	137	34	stress	stress	NN
cord-270469-lle32mha	137	35	pathway	pathway	NN
cord-270469-lle32mha	137	36	[	[	-LRB-
cord-270469-lle32mha	137	37	16	16	CD
cord-270469-lle32mha	137	38	,	,	,
cord-270469-lle32mha	137	39	18	18	CD
cord-270469-lle32mha	137	40	]	]	-RRB-
cord-270469-lle32mha	137	41	.	.	.
cord-270469-lle32mha	138	1	Therefore	therefore	RB
cord-270469-lle32mha	138	2	the	the	DT
cord-270469-lle32mha	138	3	activation	activation	NN
cord-270469-lle32mha	138	4	of	of	IN
cord-270469-lle32mha	138	5	IRE1	IRE1	NNP
cord-270469-lle32mha	138	6	and	and	CC
cord-270469-lle32mha	138	7	XBP1s	XBP1s	NNP
cord-270469-lle32mha	138	8	by	by	IN
cord-270469-lle32mha	138	9	TLRs	tlr	NNS
cord-270469-lle32mha	138	10	does	do	VBZ
cord-270469-lle32mha	138	11	not	not	RB
cord-270469-lle32mha	138	12	trigger	trigger	VB
cord-270469-lle32mha	138	13	a	a	DT
cord-270469-lle32mha	138	14	full	full	JJ
cord-270469-lle32mha	138	15	ER	er	NN
cord-270469-lle32mha	138	16	-	-	HYPH
cord-270469-lle32mha	138	17	stress	stress	NN
cord-270469-lle32mha	138	18	response	response	NN
cord-270469-lle32mha	138	19	but	but	CC
cord-270469-lle32mha	138	20	an	an	DT
cord-270469-lle32mha	138	21	XBP1s	XBP1s	NNP
cord-270469-lle32mha	138	22	dependent	dependent	JJ
cord-270469-lle32mha	138	23	program	program	NN
cord-270469-lle32mha	138	24	that	that	WDT
cord-270469-lle32mha	138	25	synergizes	synergize	VBZ
cord-270469-lle32mha	138	26	with	with	IN
cord-270469-lle32mha	138	27	TLR	TLR	NNP
cord-270469-lle32mha	138	28	signaling	signal	VBG
cord-270469-lle32mha	138	29	pathways	pathway	NNS
cord-270469-lle32mha	138	30	.	.	.
cord-270469-lle32mha	139	1	The	the	DT
cord-270469-lle32mha	139	2	induction	induction	NN
cord-270469-lle32mha	139	3	of	of	IN
cord-270469-lle32mha	139	4	XBP1s	XBP1s	NNP
cord-270469-lle32mha	139	5	amplifies	amplify	VBZ
cord-270469-lle32mha	139	6	TLR	TLR	NNP
cord-270469-lle32mha	139	7	responses	response	NNS
cord-270469-lle32mha	139	8	leading	lead	VBG
cord-270469-lle32mha	139	9	to	to	IN
cord-270469-lle32mha	139	10	increased	increase	VBN
cord-270469-lle32mha	139	11	cytokine	cytokine	NN
cord-270469-lle32mha	139	12	production	production	NN
cord-270469-lle32mha	139	13	[	[	-LRB-
cord-270469-lle32mha	139	14	16	16	CD
cord-270469-lle32mha	139	15	,	,	,
cord-270469-lle32mha	139	16	18	18	CD
cord-270469-lle32mha	139	17	]	]	-RRB-
cord-270469-lle32mha	139	18	.	.	.
cord-270469-lle32mha	140	1	This	this	DT
cord-270469-lle32mha	140	2	demonstrates	demonstrate	VBZ
cord-270469-lle32mha	140	3	that	that	DT
cord-270469-lle32mha	140	4	specific	specific	JJ
cord-270469-lle32mha	140	5	engagement	engagement	NN
cord-270469-lle32mha	140	6	of	of	IN
cord-270469-lle32mha	140	7	ER	er	NN
cord-270469-lle32mha	140	8	-	-	HYPH
cord-270469-lle32mha	140	9	signaling	signal	VBG
cord-270469-lle32mha	140	10	pathways	pathway	NNS
cord-270469-lle32mha	140	11	in	in	IN
cord-270469-lle32mha	140	12	absence	absence	NN
cord-270469-lle32mha	140	13	of	of	IN
cord-270469-lle32mha	140	14	ERstress	ERstress	NNP
cord-270469-lle32mha	140	15	can	can	MD
cord-270469-lle32mha	140	16	contribute	contribute	VB
cord-270469-lle32mha	140	17	to	to	IN
cord-270469-lle32mha	140	18	immunity	immunity	NN
cord-270469-lle32mha	140	19	.	.	.
cord-270469-lle32mha	141	1	XBP1s	XBP1s	NNP
cord-270469-lle32mha	141	2	activation	activation	NN
cord-270469-lle32mha	141	3	in	in	IN
cord-270469-lle32mha	141	4	the	the	DT
cord-270469-lle32mha	141	5	context	context	NN
cord-270469-lle32mha	141	6	of	of	IN
cord-270469-lle32mha	141	7	ER	er	NN
cord-270469-lle32mha	141	8	-	-	HYPH
cord-270469-lle32mha	141	9	stress	stress	NN
cord-270469-lle32mha	141	10	can	can	MD
cord-270469-lle32mha	141	11	also	also	RB
cord-270469-lle32mha	141	12	enhance	enhance	VB
cord-270469-lle32mha	141	13	TLRs	TLRs	NNP
cord-270469-lle32mha	141	14	responses	response	NNS
cord-270469-lle32mha	141	15	.	.	.
cord-270469-lle32mha	142	1	Macrophages	macrophage	NNS
cord-270469-lle32mha	142	2	treated	treat	VBN
cord-270469-lle32mha	142	3	with	with	IN
cord-270469-lle32mha	142	4	pharmacological	pharmacological	JJ
cord-270469-lle32mha	142	5	agents	agent	NNS
cord-270469-lle32mha	142	6	disrupting	disrupt	VBG
cord-270469-lle32mha	142	7	ER	ER	NNP
cord-270469-lle32mha	142	8	homeostasis	homeostasis	NN
cord-270469-lle32mha	142	9	display	display	NN
cord-270469-lle32mha	142	10	a	a	DT
cord-270469-lle32mha	142	11	dramatically	dramatically	RB
cord-270469-lle32mha	142	12	enhanced	enhance	VBN
cord-270469-lle32mha	142	13	response	response	NN
cord-270469-lle32mha	142	14	to	to	IN
cord-270469-lle32mha	142	15	TLR4	TLR4	NNP
cord-270469-lle32mha	142	16	and	and	CC
cord-270469-lle32mha	142	17	TLR2	TLR2	NNP
cord-270469-lle32mha	142	18	activation	activation	NN
cord-270469-lle32mha	142	19	[	[	-LRB-
cord-270469-lle32mha	142	20	16	16	CD
cord-270469-lle32mha	142	21	,	,	,
cord-270469-lle32mha	142	22	20	20	CD
cord-270469-lle32mha	142	23	]	]	-RRB-
cord-270469-lle32mha	142	24	.	.	.
cord-270469-lle32mha	143	1	The	the	DT
cord-270469-lle32mha	143	2	mechanisms	mechanism	NNS
cord-270469-lle32mha	143	3	by	by	IN
cord-270469-lle32mha	143	4	which	which	WDT
cord-270469-lle32mha	143	5	XBP1s	XBP1s	NNP
cord-270469-lle32mha	143	6	enhances	enhance	VBZ
cord-270469-lle32mha	143	7	cytokine	cytokine	NN
cord-270469-lle32mha	143	8	production	production	NN
cord-270469-lle32mha	143	9	is	be	VBZ
cord-270469-lle32mha	143	10	still	still	RB
cord-270469-lle32mha	143	11	unclear	unclear	JJ
cord-270469-lle32mha	143	12	but	but	CC
cord-270469-lle32mha	143	13	may	may	MD
cord-270469-lle32mha	143	14	likely	likely	RB
cord-270469-lle32mha	143	15	involve	involve	VB
cord-270469-lle32mha	143	16	XBP1	XBP1	NNP
cord-270469-lle32mha	143	17	binding	bind	VBG
cord-270469-lle32mha	143	18	at	at	IN
cord-270469-lle32mha	143	19	cytokine	cytokine	NN
cord-270469-lle32mha	143	20	promoters	promoter	NNS
cord-270469-lle32mha	143	21	[	[	-LRB-
cord-270469-lle32mha	143	22	21	21	CD
cord-270469-lle32mha	143	23	]	]	-RRB-
cord-270469-lle32mha	143	24	.	.	.
cord-270469-lle32mha	144	1	In	in	IN
cord-270469-lle32mha	144	2	addition	addition	NN
cord-270469-lle32mha	144	3	to	to	IN
cord-270469-lle32mha	144	4	XBP1	XBP1	NNP
cord-270469-lle32mha	144	5	,	,	,
cord-270469-lle32mha	144	6	the	the	DT
cord-270469-lle32mha	144	7	ER	ER	NNP
cord-270469-lle32mha	144	8	stress	stress	NN
cord-270469-lle32mha	144	9	-	-	HYPH
cord-270469-lle32mha	144	10	induced	induce	VBN
cord-270469-lle32mha	144	11	transcription	transcription	NN
cord-270469-lle32mha	144	12	factor	factor	NN
cord-270469-lle32mha	144	13	C	C	NNP
cord-270469-lle32mha	144	14	/	/	SYM
cord-270469-lle32mha	144	15	EBP	ebp	NN
cord-270469-lle32mha	144	16	homologous	homologous	JJ
cord-270469-lle32mha	144	17	protein	protein	NN
cord-270469-lle32mha	144	18	(	(	-LRB-
cord-270469-lle32mha	144	19	CHOP	CHOP	NNP
cord-270469-lle32mha	144	20	)	)	-RRB-
cord-270469-lle32mha	144	21	,	,	,
cord-270469-lle32mha	144	22	is	be	VBZ
cord-270469-lle32mha	144	23	involved	involve	VBN
cord-270469-lle32mha	144	24	in	in	IN
cord-270469-lle32mha	144	25	the	the	DT
cord-270469-lle32mha	144	26	upregulation	upregulation	NN
cord-270469-lle32mha	144	27	of	of	IN
cord-270469-lle32mha	144	28	cytokines	cytokine	NNS
cord-270469-lle32mha	144	29	including	include	VBG
cord-270469-lle32mha	144	30	IL-23	IL-23	NNP
cord-270469-lle32mha	144	31	in	in	IN
cord-270469-lle32mha	144	32	the	the	DT
cord-270469-lle32mha	144	33	context	context	NN
cord-270469-lle32mha	144	34	of	of	IN
cord-270469-lle32mha	144	35	dendritic	dendritic	JJ
cord-270469-lle32mha	144	36	cells	cell	NNS
cord-270469-lle32mha	144	37	undergoing	undergo	VBG
cord-270469-lle32mha	144	38	both	both	CC
cord-270469-lle32mha	144	39	ER	ER	NNP
cord-270469-lle32mha	144	40	stress	stress	NN
cord-270469-lle32mha	144	41	and	and	CC
cord-270469-lle32mha	144	42	TLR	TLR	NNP
cord-270469-lle32mha	144	43	stimulation	stimulation	NN
cord-270469-lle32mha	144	44	[	[	-LRB-
cord-270469-lle32mha	144	45	23	23	CD
cord-270469-lle32mha	144	46	]	]	-RRB-
cord-270469-lle32mha	144	47	.	.	.
cord-270469-lle32mha	145	1	Knockdown	knockdown	NN
cord-270469-lle32mha	145	2	of	of	IN
cord-270469-lle32mha	145	3	CHOP	chop	NN
cord-270469-lle32mha	145	4	in	in	IN
cord-270469-lle32mha	145	5	a	a	DT
cord-270469-lle32mha	145	6	monocytic	monocytic	JJ
cord-270469-lle32mha	145	7	cell	cell	NN
cord-270469-lle32mha	145	8	line	line	NN
cord-270469-lle32mha	145	9	significantly	significantly	RB
cord-270469-lle32mha	145	10	reduced	reduce	VBD
cord-270469-lle32mha	145	11	the	the	DT
cord-270469-lle32mha	145	12	synergistic	synergistic	JJ
cord-270469-lle32mha	145	13	effects	effect	NNS
cord-270469-lle32mha	145	14	of	of	IN
cord-270469-lle32mha	145	15	ER	er	NN
cord-270469-lle32mha	145	16	-	-	HYPH
cord-270469-lle32mha	145	17	stress	stress	NN
cord-270469-lle32mha	145	18	and	and	CC
cord-270469-lle32mha	145	19	TLRs	tlr	NNS
cord-270469-lle32mha	145	20	on	on	IN
cord-270469-lle32mha	145	21	IL-23	IL-23	NNP
cord-270469-lle32mha	145	22	expression	expression	NN
cord-270469-lle32mha	145	23	.	.	.
cord-270469-lle32mha	146	1	Therefore	therefore	RB
cord-270469-lle32mha	146	2	diverse	diverse	JJ
cord-270469-lle32mha	146	3	ER	ER	NNP
cord-270469-lle32mha	146	4	stress	stress	NN
cord-270469-lle32mha	146	5	-	-	HYPH
cord-270469-lle32mha	146	6	related	relate	VBN
cord-270469-lle32mha	146	7	transcriptional	transcriptional	JJ
cord-270469-lle32mha	146	8	pathways	pathway	NNS
cord-270469-lle32mha	146	9	can	can	MD
cord-270469-lle32mha	146	10	affect	affect	VB
cord-270469-lle32mha	146	11	the	the	DT
cord-270469-lle32mha	146	12	nature	nature	NN
cord-270469-lle32mha	146	13	of	of	IN
cord-270469-lle32mha	146	14	immune	immune	JJ
cord-270469-lle32mha	146	15	responses	response	NNS
cord-270469-lle32mha	146	16	(	(	-LRB-
cord-270469-lle32mha	146	17	Fig	Fig	NNP
cord-270469-lle32mha	146	18	.	.	.
cord-270469-lle32mha	146	19	3	3	CD
cord-270469-lle32mha	146	20	)	)	-RRB-
cord-270469-lle32mha	146	21	.	.	.
cord-270469-lle32mha	147	1	The	the	DT
cord-270469-lle32mha	147	2	ER	er	NN
cord-270469-lle32mha	147	3	-	-	HYPH
cord-270469-lle32mha	147	4	stress	stress	NN
cord-270469-lle32mha	147	5	response	response	NN
cord-270469-lle32mha	147	6	and	and	CC
cord-270469-lle32mha	147	7	inflammation	inflammation	NN
cord-270469-lle32mha	147	8	are	be	VBP
cord-270469-lle32mha	147	9	interconnected	interconnect	VBN
cord-270469-lle32mha	147	10	through	through	IN
cord-270469-lle32mha	147	11	various	various	JJ
cord-270469-lle32mha	147	12	additional	additional	JJ
cord-270469-lle32mha	147	13	mechanisms	mechanism	NNS
cord-270469-lle32mha	147	14	.	.	.
cord-270469-lle32mha	148	1	The	the	DT
cord-270469-lle32mha	148	2	production	production	NN
cord-270469-lle32mha	148	3	of	of	IN
cord-270469-lle32mha	148	4	reactive	reactive	JJ
cord-270469-lle32mha	148	5	oxygen	oxygen	NN
cord-270469-lle32mha	148	6	species	specie	NNS
cord-270469-lle32mha	148	7	(	(	-LRB-
cord-270469-lle32mha	148	8	ROS	ROS	NNP
cord-270469-lle32mha	148	9	)	)	-RRB-
cord-270469-lle32mha	148	10	,	,	,
cord-270469-lle32mha	148	11	the	the	DT
cord-270469-lle32mha	148	12	activation	activation	NN
cord-270469-lle32mha	148	13	of	of	IN
cord-270469-lle32mha	148	14	the	the	DT
cord-270469-lle32mha	148	15	transcription	transcription	NN
cord-270469-lle32mha	148	16	factor	factor	NN
cord-270469-lle32mha	148	17	nuclear	nuclear	JJ
cord-270469-lle32mha	148	18	factor	factor	NN
cord-270469-lle32mha	148	19	-	-	HYPH
cord-270469-lle32mha	148	20	kB	kB	NNP
cord-270469-lle32mha	148	21	(	(	-LRB-
cord-270469-lle32mha	148	22	NF	NF	NNP
cord-270469-lle32mha	148	23	-	-	HYPH
cord-270469-lle32mha	148	24	kB	kB	NNP
cord-270469-lle32mha	148	25	)	)	-RRB-
cord-270469-lle32mha	149	1	and	and	CC
cord-270469-lle32mha	149	2	the	the	DT
cord-270469-lle32mha	149	3	induction	induction	NN
cord-270469-lle32mha	149	4	of	of	IN
cord-270469-lle32mha	149	5	acute	acute	JJ
cord-270469-lle32mha	149	6	-	-	HYPH
cord-270469-lle32mha	149	7	phase	phase	NN
cord-270469-lle32mha	149	8	proteins	protein	NNS
cord-270469-lle32mha	149	9	have	have	VBP
cord-270469-lle32mha	149	10	being	be	VBG
cord-270469-lle32mha	149	11	linked	link	VBN
cord-270469-lle32mha	149	12	to	to	IN
cord-270469-lle32mha	149	13	both	both	CC
cord-270469-lle32mha	149	14	ER	er	NN
cord-270469-lle32mha	149	15	-	-	HYPH
cord-270469-lle32mha	149	16	stress	stress	NN
cord-270469-lle32mha	149	17	and	and	CC
cord-270469-lle32mha	149	18	inflammatory	inflammatory	JJ
cord-270469-lle32mha	149	19	responses	response	NNS
cord-270469-lle32mha	149	20	[	[	-LRB-
cord-270469-lle32mha	149	21	25	25	CD
cord-270469-lle32mha	149	22	]	]	-RRB-
cord-270469-lle32mha	149	23	.	.	.
cord-270469-lle32mha	150	1	Immune	immune	JJ
cord-270469-lle32mha	150	2	cells	cell	NNS
cord-270469-lle32mha	150	3	can	can	MD
cord-270469-lle32mha	150	4	also	also	RB
cord-270469-lle32mha	150	5	respond	respond	VB
cord-270469-lle32mha	150	6	to	to	IN
cord-270469-lle32mha	150	7	stress	stress	NN
cord-270469-lle32mha	150	8	signals	signal	NNS
cord-270469-lle32mha	150	9	released	release	VBN
cord-270469-lle32mha	150	10	by	by	IN
cord-270469-lle32mha	150	11	other	other	JJ
cord-270469-lle32mha	150	12	tissues	tissue	NNS
cord-270469-lle32mha	150	13	.	.	.
cord-270469-lle32mha	151	1	A	a	DT
cord-270469-lle32mha	151	2	recent	recent	JJ
cord-270469-lle32mha	151	3	report	report	NN
cord-270469-lle32mha	151	4	suggests	suggest	VBZ
cord-270469-lle32mha	151	5	that	that	IN
cord-270469-lle32mha	151	6	stressed	stress	VBD
cord-270469-lle32mha	151	7	cells	cell	NNS
cord-270469-lle32mha	151	8	can	can	MD
cord-270469-lle32mha	151	9	transmit	transmit	VB
cord-270469-lle32mha	151	10	(	(	-LRB-
cord-270469-lle32mha	151	11	via	via	IN
cord-270469-lle32mha	151	12	a	a	DT
cord-270469-lle32mha	151	13	yet	yet	RB
cord-270469-lle32mha	151	14	to	to	TO
cord-270469-lle32mha	151	15	be	be	VB
cord-270469-lle32mha	151	16	defined	define	VBN
cord-270469-lle32mha	151	17	stress	stress	NN
cord-270469-lle32mha	151	18	signal	signal	NN
cord-270469-lle32mha	151	19	)	)	-RRB-
cord-270469-lle32mha	151	20	ER	er	NN
cord-270469-lle32mha	151	21	-	-	HYPH
cord-270469-lle32mha	151	22	stress	stress	NN
cord-270469-lle32mha	151	23	conditions	condition	NNS
cord-270469-lle32mha	151	24	to	to	IN
cord-270469-lle32mha	151	25	macrophages	macrophage	NNS
cord-270469-lle32mha	151	26	,	,	,
cord-270469-lle32mha	151	27	increasing	increase	VBG
cord-270469-lle32mha	151	28	inflammatory	inflammatory	JJ
cord-270469-lle32mha	151	29	responses	response	NNS
cord-270469-lle32mha	151	30	[	[	-LRB-
cord-270469-lle32mha	151	31	27	27	CD
cord-270469-lle32mha	151	32	]	]	-RRB-
cord-270469-lle32mha	151	33	.	.	.
cord-270469-lle32mha	152	1	Incubation	incubation	NN
cord-270469-lle32mha	152	2	of	of	IN
cord-270469-lle32mha	152	3	macrophages	macrophage	NNS
cord-270469-lle32mha	152	4	with	with	IN
cord-270469-lle32mha	152	5	cultured	cultured	JJ
cord-270469-lle32mha	152	6	conditioned	condition	VBN
cord-270469-lle32mha	152	7	medium	medium	NN
cord-270469-lle32mha	152	8	from	from	IN
cord-270469-lle32mha	152	9	ERstressed	erstressed	JJ
cord-270469-lle32mha	152	10	cells	cell	NNS
cord-270469-lle32mha	152	11	promotes	promote	VBZ
cord-270469-lle32mha	152	12	IRE1	IRE1	NNP
cord-270469-lle32mha	152	13	activation	activation	NN
cord-270469-lle32mha	152	14	and	and	CC
cord-270469-lle32mha	152	15	protein	protein	NN
cord-270469-lle32mha	152	16	chaperones	chaperone	NNS
cord-270469-lle32mha	152	17	upregulation	upregulation	NN
cord-270469-lle32mha	152	18	in	in	IN
cord-270469-lle32mha	152	19	the	the	DT
cord-270469-lle32mha	152	20	macrophages	macrophage	NNS
cord-270469-lle32mha	152	21	that	that	WDT
cord-270469-lle32mha	152	22	deploy	deploy	VBP
cord-270469-lle32mha	152	23	a	a	DT
cord-270469-lle32mha	152	24	more	more	RBR
cord-270469-lle32mha	152	25	sustained	sustained	JJ
cord-270469-lle32mha	152	26	proinflammatory	proinflammatory	JJ
cord-270469-lle32mha	152	27	response	response	NN
cord-270469-lle32mha	152	28	.	.	.
cord-270469-lle32mha	153	1	Similarly	similarly	RB
cord-270469-lle32mha	153	2	injection	injection	NN
cord-270469-lle32mha	153	3	into	into	IN
cord-270469-lle32mha	153	4	mice	mouse	NNS
cord-270469-lle32mha	153	5	of	of	IN
cord-270469-lle32mha	153	6	media	medium	NNS
cord-270469-lle32mha	153	7	supernatant	supernatant	VBN
cord-270469-lle32mha	153	8	harvested	harvest	VBN
cord-270469-lle32mha	153	9	from	from	IN
cord-270469-lle32mha	153	10	ERstressed	ERstressed	NNP
cord-270469-lle32mha	153	11	cells	cell	NNS
cord-270469-lle32mha	153	12	elicit	elicit	VBP
cord-270469-lle32mha	153	13	the	the	DT
cord-270469-lle32mha	153	14	upregulation	upregulation	NN
cord-270469-lle32mha	153	15	of	of	IN
cord-270469-lle32mha	153	16	genes	gene	NNS
cord-270469-lle32mha	153	17	typically	typically	RB
cord-270469-lle32mha	153	18	associated	associate	VBN
cord-270469-lle32mha	153	19	with	with	IN
cord-270469-lle32mha	153	20	ER	ER	NNP
cord-270469-lle32mha	153	21	stress	stress	NN
cord-270469-lle32mha	153	22	responses	response	NNS
cord-270469-lle32mha	153	23	in	in	IN
cord-270469-lle32mha	153	24	the	the	DT
cord-270469-lle32mha	153	25	liver	liver	NN
cord-270469-lle32mha	153	26	[	[	-LRB-
cord-270469-lle32mha	153	27	27	27	CD
cord-270469-lle32mha	153	28	]	]	-RRB-
cord-270469-lle32mha	153	29	.	.	.
cord-270469-lle32mha	154	1	These	these	DT
cord-270469-lle32mha	154	2	observations	observation	NNS
cord-270469-lle32mha	154	3	may	may	MD
cord-270469-lle32mha	154	4	indicate	indicate	VB
cord-270469-lle32mha	154	5	that	that	IN
cord-270469-lle32mha	154	6	loss	loss	NN
cord-270469-lle32mha	154	7	of	of	IN
cord-270469-lle32mha	154	8	ER	ER	NNP
cord-270469-lle32mha	154	9	homeostasis	homeostasis	NN
cord-270469-lle32mha	154	10	in	in	IN
cord-270469-lle32mha	154	11	tissues	tissue	NNS
cord-270469-lle32mha	154	12	can	can	MD
cord-270469-lle32mha	154	13	be	be	VB
cord-270469-lle32mha	154	14	transmitted	transmit	VBN
cord-270469-lle32mha	154	15	to	to	IN
cord-270469-lle32mha	154	16	the	the	DT
cord-270469-lle32mha	154	17	microenvironment	microenvironment	NN
cord-270469-lle32mha	154	18	and	and	CC
cord-270469-lle32mha	154	19	immune	immune	JJ
cord-270469-lle32mha	154	20	cells	cell	NNS
cord-270469-lle32mha	154	21	to	to	TO
cord-270469-lle32mha	154	22	augment	augment	VB
cord-270469-lle32mha	154	23	immune	immune	JJ
cord-270469-lle32mha	154	24	responses	response	NNS
cord-270469-lle32mha	154	25	[	[	-LRB-
cord-270469-lle32mha	154	26	31	31	CD
cord-270469-lle32mha	154	27	]	]	-RRB-
cord-270469-lle32mha	154	28	.	.	.
cord-270469-lle32mha	155	1	Whether	whether	IN
cord-270469-lle32mha	155	2	this	this	DT
cord-270469-lle32mha	155	3	phenomenon	phenomenon	NN
cord-270469-lle32mha	155	4	is	be	VBZ
cord-270469-lle32mha	155	5	relevant	relevant	JJ
cord-270469-lle32mha	155	6	to	to	IN
cord-270469-lle32mha	155	7	the	the	DT
cord-270469-lle32mha	155	8	pathology	pathology	NN
cord-270469-lle32mha	155	9	of	of	IN
cord-270469-lle32mha	155	10	inflammatory	inflammatory	JJ
cord-270469-lle32mha	155	11	diseases	disease	NNS
cord-270469-lle32mha	155	12	characterized	characterize	VBN
cord-270469-lle32mha	155	13	by	by	IN
cord-270469-lle32mha	155	14	the	the	DT
cord-270469-lle32mha	155	15	loss	loss	NN
cord-270469-lle32mha	155	16	of	of	IN
cord-270469-lle32mha	155	17	ER	er	NN
cord-270469-lle32mha	155	18	-	-	HYPH
cord-270469-lle32mha	155	19	homeostasis	homeostasis	NN
cord-270469-lle32mha	155	20	in	in	IN
cord-270469-lle32mha	155	21	tissues	tissue	NNS
cord-270469-lle32mha	155	22	is	be	VBZ
cord-270469-lle32mha	155	23	an	an	DT
cord-270469-lle32mha	155	24	exciting	exciting	JJ
cord-270469-lle32mha	155	25	question	question	NN
cord-270469-lle32mha	155	26	that	that	WDT
cord-270469-lle32mha	155	27	remains	remain	VBZ
cord-270469-lle32mha	155	28	to	to	TO
cord-270469-lle32mha	155	29	be	be	VB
cord-270469-lle32mha	155	30	addressed	address	VBN
cord-270469-lle32mha	155	31	.	.	.
cord-270469-lle32mha	156	1	ER	er	NN
cord-270469-lle32mha	156	2	-	-	HYPH
cord-270469-lle32mha	156	3	stress	stress	NN
cord-270469-lle32mha	156	4	pathways	pathway	NNS
cord-270469-lle32mha	156	5	are	be	VBP
cord-270469-lle32mha	156	6	also	also	RB
cord-270469-lle32mha	156	7	implicated	implicate	VBN
cord-270469-lle32mha	156	8	in	in	IN
cord-270469-lle32mha	156	9	regulating	regulate	VBG
cord-270469-lle32mha	156	10	immunogenicity	immunogenicity	NN
cord-270469-lle32mha	156	11	.	.	.
cord-270469-lle32mha	157	1	It	-PRON-	PRP
cord-270469-lle32mha	157	2	has	have	VBZ
cord-270469-lle32mha	157	3	been	be	VBN
cord-270469-lle32mha	157	4	shown	show	VBN
cord-270469-lle32mha	157	5	that	that	IN
cord-270469-lle32mha	157	6	in	in	IN
cord-270469-lle32mha	157	7	tumor	tumor	NN
cord-270469-lle32mha	157	8	cells	cell	NNS
cord-270469-lle32mha	157	9	dying	die	VBG
cord-270469-lle32mha	157	10	upon	upon	IN
cord-270469-lle32mha	157	11	treatment	treatment	NN
cord-270469-lle32mha	157	12	with	with	IN
cord-270469-lle32mha	157	13	anticancer	anticancer	JJ
cord-270469-lle32mha	157	14	therapy	therapy	NN
cord-270469-lle32mha	157	15	,	,	,
cord-270469-lle32mha	157	16	ER	er	NN
cord-270469-lle32mha	157	17	-	-	HYPH
cord-270469-lle32mha	157	18	stress	stress	NN
cord-270469-lle32mha	157	19	promotes	promote	VBZ
cord-270469-lle32mha	157	20	cell	cell	NN
cord-270469-lle32mha	157	21	-	-	HYPH
cord-270469-lle32mha	157	22	surface	surface	NN
cord-270469-lle32mha	157	23	localization	localization	NN
cord-270469-lle32mha	157	24	of	of	IN
cord-270469-lle32mha	157	25	factors	factor	NNS
cord-270469-lle32mha	157	26	involved	involve	VBN
cord-270469-lle32mha	157	27	in	in	IN
cord-270469-lle32mha	157	28	immunogenic	immunogenic	JJ
cord-270469-lle32mha	157	29	cell	cell	NN
cord-270469-lle32mha	157	30	death	death	NN
cord-270469-lle32mha	157	31	[	[	-LRB-
cord-270469-lle32mha	157	32	32	32	CD
cord-270469-lle32mha	157	33	,	,	,
cord-270469-lle32mha	157	34	34	34	CD
cord-270469-lle32mha	157	35	]	]	-RRB-
cord-270469-lle32mha	157	36	.	.	.
cord-270469-lle32mha	158	1	Calreticulin	Calreticulin	NNP
cord-270469-lle32mha	158	2	is	be	VBZ
cord-270469-lle32mha	158	3	the	the	DT
cord-270469-lle32mha	158	4	best	well	RBS
cord-270469-lle32mha	158	5	-	-	HYPH
cord-270469-lle32mha	158	6	characterized	characterize	VBN
cord-270469-lle32mha	158	7	immunogenic	immunogenic	JJ
cord-270469-lle32mha	158	8	signal	signal	NN
cord-270469-lle32mha	158	9	emerging	emerge	VBG
cord-270469-lle32mha	158	10	from	from	IN
cord-270469-lle32mha	158	11	the	the	DT
cord-270469-lle32mha	158	12	ER	ER	NNP
cord-270469-lle32mha	158	13	.	.	.
cord-270469-lle32mha	159	1	This	this	DT
cord-270469-lle32mha	159	2	ERresident	ERresident	NNP
cord-270469-lle32mha	159	3	chaperone	chaperone	NN
cord-270469-lle32mha	159	4	delocalize	delocalize	NN
cord-270469-lle32mha	159	5	on	on	IN
cord-270469-lle32mha	159	6	the	the	DT
cord-270469-lle32mha	159	7	cell	cell	NN
cord-270469-lle32mha	159	8	surface	surface	NN
cord-270469-lle32mha	159	9	where	where	WRB
cord-270469-lle32mha	159	10	it	-PRON-	PRP
cord-270469-lle32mha	159	11	can	can	MD
cord-270469-lle32mha	159	12	act	act	VB
cord-270469-lle32mha	159	13	as	as	IN
cord-270469-lle32mha	159	14	an	an	DT
cord-270469-lle32mha	159	15	"	"	``
cord-270469-lle32mha	159	16	eat	eat	VBP
cord-270469-lle32mha	159	17	me	-PRON-	PRP
cord-270469-lle32mha	159	18	"	"	''
cord-270469-lle32mha	159	19	or	or	CC
cord-270469-lle32mha	159	20	"	"	``
cord-270469-lle32mha	159	21	danger	danger	NN
cord-270469-lle32mha	159	22	"	"	''
cord-270469-lle32mha	159	23	signal	signal	NN
cord-270469-lle32mha	159	24	that	that	IN
cord-270469-lle32mha	159	25	primes	prime	VBZ
cord-270469-lle32mha	159	26	immune	immune	JJ
cord-270469-lle32mha	159	27	responses	response	NNS
cord-270469-lle32mha	159	28	directed	direct	VBN
cord-270469-lle32mha	159	29	against	against	IN
cord-270469-lle32mha	159	30	the	the	DT
cord-270469-lle32mha	159	31	stressed	stressed	JJ
cord-270469-lle32mha	159	32	cell	cell	NN
cord-270469-lle32mha	159	33	[	[	-LRB-
cord-270469-lle32mha	159	34	35	35	CD
cord-270469-lle32mha	159	35	]	]	-RRB-
cord-270469-lle32mha	159	36	.	.	.
cord-270469-lle32mha	160	1	The	the	DT
cord-270469-lle32mha	160	2	exposure	exposure	NN
cord-270469-lle32mha	160	3	of	of	IN
cord-270469-lle32mha	160	4	calreticulin	calreticulin	NNP
cord-270469-lle32mha	160	5	on	on	IN
cord-270469-lle32mha	160	6	the	the	DT
cord-270469-lle32mha	160	7	cell	cell	NN
cord-270469-lle32mha	160	8	surface	surface	NN
cord-270469-lle32mha	160	9	is	be	VBZ
cord-270469-lle32mha	160	10	associated	associate	VBN
cord-270469-lle32mha	160	11	with	with	IN
cord-270469-lle32mha	160	12	the	the	DT
cord-270469-lle32mha	160	13	induction	induction	NN
cord-270469-lle32mha	160	14	of	of	IN
cord-270469-lle32mha	160	15	ER	ER	NNP
cord-270469-lle32mha	160	16	-	-	HYPH
cord-270469-lle32mha	160	17	stress	stress	NN
cord-270469-lle32mha	160	18	[	[	-LRB-
cord-270469-lle32mha	160	19	37	37	CD
cord-270469-lle32mha	160	20	,	,	,
cord-270469-lle32mha	160	21	39	39	CD
cord-270469-lle32mha	160	22	]	]	-RRB-
cord-270469-lle32mha	160	23	and	and	CC
cord-270469-lle32mha	160	24	may	may	MD
cord-270469-lle32mha	160	25	directly	directly	RB
cord-270469-lle32mha	160	26	involve	involve	VB
cord-270469-lle32mha	160	27	the	the	DT
cord-270469-lle32mha	160	28	activation	activation	NN
cord-270469-lle32mha	160	29	of	of	IN
cord-270469-lle32mha	160	30	ER	er	NN
cord-270469-lle32mha	160	31	-	-	HYPH
cord-270469-lle32mha	160	32	stress	stress	NN
cord-270469-lle32mha	160	33	signaling	signal	VBG
cord-270469-lle32mha	160	34	pathways	pathway	NNS
cord-270469-lle32mha	160	35	such	such	JJ
cord-270469-lle32mha	160	36	as	as	IN
cord-270469-lle32mha	160	37	the	the	DT
cord-270469-lle32mha	160	38	PERK	perk	NN
cord-270469-lle32mha	160	39	pathway	pathway	NN
cord-270469-lle32mha	160	40	[	[	-LRB-
cord-270469-lle32mha	160	41	32	32	CD
cord-270469-lle32mha	160	42	]	]	-RRB-
cord-270469-lle32mha	160	43	.	.	.
cord-270469-lle32mha	161	1	Therefore	therefore	RB
cord-270469-lle32mha	161	2	ER	er	NN
cord-270469-lle32mha	161	3	-	-	HYPH
cord-270469-lle32mha	161	4	stress	stress	NN
cord-270469-lle32mha	161	5	specific	specific	JJ
cord-270469-lle32mha	161	6	signal	signal	NN
cord-270469-lle32mha	161	7	may	may	MD
cord-270469-lle32mha	161	8	increase	increase	VB
cord-270469-lle32mha	161	9	immunogenicity	immunogenicity	NN
cord-270469-lle32mha	161	10	by	by	IN
cord-270469-lle32mha	161	11	tagging	tag	VBG
cord-270469-lle32mha	161	12	the	the	DT
cord-270469-lle32mha	161	13	cell	cell	NN
cord-270469-lle32mha	161	14	as	as	IN
cord-270469-lle32mha	161	15	stressed	stress	VBD
cord-270469-lle32mha	161	16	[	[	-LRB-
cord-270469-lle32mha	161	17	34	34	CD
cord-270469-lle32mha	161	18	,	,	,
cord-270469-lle32mha	161	19	34	34	CD
cord-270469-lle32mha	161	20	,	,	,
cord-270469-lle32mha	161	21	42	42	CD
cord-270469-lle32mha	161	22	]	]	-RRB-
cord-270469-lle32mha	161	23	.	.	.
cord-270469-lle32mha	162	1	Pathogens	pathogen	NNS
cord-270469-lle32mha	162	2	activate	activate	VBP
cord-270469-lle32mha	162	3	ER	ER	NNP
cord-270469-lle32mha	162	4	-	-	HYPH
cord-270469-lle32mha	162	5	signaling	signal	VBG
cord-270469-lle32mha	162	6	pathways	pathway	NNS
cord-270469-lle32mha	162	7	such	such	JJ
cord-270469-lle32mha	162	8	as	as	IN
cord-270469-lle32mha	162	9	IRE1	IRE1	NNP
cord-270469-lle32mha	162	10	by	by	IN
cord-270469-lle32mha	162	11	directly	directly	RB
cord-270469-lle32mha	162	12	engaging	engage	VBG
cord-270469-lle32mha	162	13	innate	innate	JJ
cord-270469-lle32mha	162	14	immune	immune	JJ
cord-270469-lle32mha	162	15	receptors	receptor	NNS
cord-270469-lle32mha	162	16	as	as	IN
cord-270469-lle32mha	162	17	it	-PRON-	PRP
cord-270469-lle32mha	162	18	was	be	VBD
cord-270469-lle32mha	162	19	shown	show	VBN
cord-270469-lle32mha	162	20	for	for	IN
cord-270469-lle32mha	162	21	TLRs	tlr	NNS
cord-270469-lle32mha	162	22	,	,	,
cord-270469-lle32mha	162	23	however	however	WRB
cord-270469-lle32mha	162	24	live	live	JJ
cord-270469-lle32mha	162	25	pathogens	pathogen	NNS
cord-270469-lle32mha	162	26	affect	affect	VBP
cord-270469-lle32mha	162	27	also	also	RB
cord-270469-lle32mha	162	28	directly	directly	RB
cord-270469-lle32mha	162	29	ER	ER	NNP
cord-270469-lle32mha	162	30	functions	function	NNS
cord-270469-lle32mha	162	31	as	as	IN
cord-270469-lle32mha	162	32	part	part	NN
cord-270469-lle32mha	162	33	of	of	IN
cord-270469-lle32mha	162	34	their	-PRON-	PRP$
cord-270469-lle32mha	162	35	infectious	infectious	JJ
cord-270469-lle32mha	162	36	and	and	CC
cord-270469-lle32mha	162	37	replicative	replicative	JJ
cord-270469-lle32mha	162	38	cycle	cycle	NN
cord-270469-lle32mha	162	39	[	[	-LRB-
cord-270469-lle32mha	162	40	9	9	CD
cord-270469-lle32mha	162	41	]	]	-RRB-
cord-270469-lle32mha	162	42	.	.	.
cord-270469-lle32mha	163	1	In	in	IN
cord-270469-lle32mha	163	2	plants	plant	NNS
cord-270469-lle32mha	163	3	,	,	,
cord-270469-lle32mha	163	4	the	the	DT
cord-270469-lle32mha	163	5	ntbZIP60	ntbZIP60	NNP
cord-270469-lle32mha	163	6	gene	gene	NN
cord-270469-lle32mha	163	7	(	(	-LRB-
cord-270469-lle32mha	163	8	a	a	DT
cord-270469-lle32mha	163	9	signaling	signal	VBG
cord-270469-lle32mha	163	10	branch	branch	NN
cord-270469-lle32mha	163	11	of	of	IN
cord-270469-lle32mha	163	12	the	the	DT
cord-270469-lle32mha	163	13	plant	plant	NN
cord-270469-lle32mha	163	14	ER	er	NN
cord-270469-lle32mha	163	15	-	-	HYPH
cord-270469-lle32mha	163	16	stress	stress	NN
cord-270469-lle32mha	163	17	response	response	NN
cord-270469-lle32mha	163	18	related	relate	VBN
cord-270469-lle32mha	163	19	to	to	IN
cord-270469-lle32mha	163	20	ATF6	ATF6	NNP
cord-270469-lle32mha	163	21	)	)	-RRB-
cord-270469-lle32mha	163	22	is	be	VBZ
cord-270469-lle32mha	163	23	activated	activate	VBN
cord-270469-lle32mha	163	24	upon	upon	IN
cord-270469-lle32mha	163	25	infection	infection	NN
cord-270469-lle32mha	163	26	of	of	IN
cord-270469-lle32mha	163	27	tobacco	tobacco	NN
cord-270469-lle32mha	163	28	leaves	leave	NNS
cord-270469-lle32mha	163	29	with	with	IN
cord-270469-lle32mha	163	30	Pseudomonas	Pseudomonas	NNP
cord-270469-lle32mha	163	31	cichorri	cichorri	NNP
cord-270469-lle32mha	163	32	.	.	.
cord-270469-lle32mha	164	1	Moreover	moreover	RB
cord-270469-lle32mha	164	2	,	,	,
cord-270469-lle32mha	164	3	silencing	silence	VBG
cord-270469-lle32mha	164	4	of	of	IN
cord-270469-lle32mha	164	5	ntbZIP60	ntbZIP60	NNP
cord-270469-lle32mha	164	6	allows	allow	VBZ
cord-270469-lle32mha	164	7	higher	high	JJR
cord-270469-lle32mha	164	8	multiplication	multiplication	NN
cord-270469-lle32mha	164	9	of	of	IN
cord-270469-lle32mha	164	10	P.	P.	NNP
cord-270469-lle32mha	164	11	cichorri	cichorri	NNP
cord-270469-lle32mha	164	12	compared	compare	VBN
cord-270469-lle32mha	164	13	to	to	TO
cord-270469-lle32mha	164	14	control	control	NN
cord-270469-lle32mha	164	15	plants	plant	NNS
cord-270469-lle32mha	164	16	[	[	-LRB-
cord-270469-lle32mha	164	17	46	46	CD
cord-270469-lle32mha	164	18	]	]	-RRB-
cord-270469-lle32mha	164	19	,	,	,
cord-270469-lle32mha	164	20	suggesting	suggest	VBG
cord-270469-lle32mha	164	21	that	that	IN
cord-270469-lle32mha	164	22	ER	er	NN
cord-270469-lle32mha	164	23	-	-	HYPH
cord-270469-lle32mha	164	24	stress	stress	NN
cord-270469-lle32mha	164	25	pathways	pathway	NNS
cord-270469-lle32mha	164	26	may	may	MD
cord-270469-lle32mha	164	27	represent	represent	VB
cord-270469-lle32mha	164	28	an	an	DT
cord-270469-lle32mha	164	29	ancestral	ancestral	JJ
cord-270469-lle32mha	164	30	mechanism	mechanism	NN
cord-270469-lle32mha	164	31	of	of	IN
cord-270469-lle32mha	164	32	immune	immune	JJ
cord-270469-lle32mha	164	33	regulation	regulation	NN
cord-270469-lle32mha	164	34	.	.	.
cord-270469-lle32mha	165	1	In	in	IN
cord-270469-lle32mha	165	2	Caenorhabditis	Caenorhabditis	NNP
cord-270469-lle32mha	165	3	elegans	elegan	NNS
cord-270469-lle32mha	165	4	infected	infect	VBN
cord-270469-lle32mha	165	5	with	with	IN
cord-270469-lle32mha	165	6	bacteria	bacteria	NNS
cord-270469-lle32mha	165	7	expressing	express	VBG
cord-270469-lle32mha	165	8	pore	pore	NN
cord-270469-lle32mha	165	9	-	-	HYPH
cord-270469-lle32mha	165	10	forming	form	VBG
cord-270469-lle32mha	165	11	toxins	toxin	NNS
cord-270469-lle32mha	165	12	,	,	,
cord-270469-lle32mha	165	13	XBP1s	XBP1s	NNP
cord-270469-lle32mha	165	14	and	and	CC
cord-270469-lle32mha	165	15	ATF6	ATF6	NNP
cord-270469-lle32mha	165	16	are	be	VBP
cord-270469-lle32mha	165	17	induced	induce	VBN
cord-270469-lle32mha	165	18	[	[	-LRB-
cord-270469-lle32mha	165	19	47	47	CD
cord-270469-lle32mha	165	20	]	]	-RRB-
cord-270469-lle32mha	165	21	.	.	.
cord-270469-lle32mha	166	1	Genetic	genetic	JJ
cord-270469-lle32mha	166	2	studies	study	NNS
cord-270469-lle32mha	166	3	have	have	VBP
cord-270469-lle32mha	166	4	shown	show	VBN
cord-270469-lle32mha	166	5	that	that	IN
cord-270469-lle32mha	166	6	these	these	DT
cord-270469-lle32mha	166	7	ER	er	NN
cord-270469-lle32mha	166	8	-	-	HYPH
cord-270469-lle32mha	166	9	stress	stress	NN
cord-270469-lle32mha	166	10	signaling	signal	VBG
cord-270469-lle32mha	166	11	pathways	pathway	NNS
cord-270469-lle32mha	166	12	augment	augment	VBP
cord-270469-lle32mha	166	13	survival	survival	NN
cord-270469-lle32mha	166	14	of	of	IN
cord-270469-lle32mha	166	15	infected	infected	JJ
cord-270469-lle32mha	166	16	worms	worm	NNS
cord-270469-lle32mha	166	17	probably	probably	RB
cord-270469-lle32mha	166	18	by	by	IN
cord-270469-lle32mha	166	19	promoting	promote	VBG
cord-270469-lle32mha	166	20	a	a	DT
cord-270469-lle32mha	166	21	protective	protective	JJ
cord-270469-lle32mha	166	22	restoration	restoration	NN
cord-270469-lle32mha	166	23	of	of	IN
cord-270469-lle32mha	166	24	ER	ER	NNP
cord-270469-lle32mha	166	25	homeostasis	homeostasis	NN
cord-270469-lle32mha	166	26	or	or	CC
cord-270469-lle32mha	166	27	by	by	IN
cord-270469-lle32mha	166	28	increasing	increase	VBG
cord-270469-lle32mha	166	29	immune	immune	JJ
cord-270469-lle32mha	166	30	responses	response	NNS
cord-270469-lle32mha	166	31	.	.	.
cord-270469-lle32mha	167	1	Similarly	similarly	RB
cord-270469-lle32mha	167	2	in	in	IN
cord-270469-lle32mha	167	3	C.	C.	NNP
cord-270469-lle32mha	167	4	elegans	elegan	NNS
cord-270469-lle32mha	167	5	infected	infect	VBN
cord-270469-lle32mha	167	6	with	with	IN
cord-270469-lle32mha	167	7	Pseudomonas	Pseudomonas	NNP
cord-270469-lle32mha	167	8	aeruginosa	aeruginosa	NN
cord-270469-lle32mha	167	9	,	,	,
cord-270469-lle32mha	167	10	activation	activation	NN
cord-270469-lle32mha	167	11	of	of	IN
cord-270469-lle32mha	167	12	IRE1	IRE1	NNP
cord-270469-lle32mha	167	13	and	and	CC
cord-270469-lle32mha	167	14	XBP1	XBP1	NNP
cord-270469-lle32mha	167	15	was	be	VBD
cord-270469-lle32mha	167	16	noted	note	VBN
cord-270469-lle32mha	167	17	[	[	-LRB-
cord-270469-lle32mha	167	18	48	48	CD
cord-270469-lle32mha	167	19	]	]	-RRB-
cord-270469-lle32mha	167	20	.	.	.
cord-270469-lle32mha	168	1	In	in	IN
cord-270469-lle32mha	168	2	this	this	DT
cord-270469-lle32mha	168	3	model	model	NN
cord-270469-lle32mha	168	4	,	,	,
cord-270469-lle32mha	168	5	XBP1	XBP1	NNP
cord-270469-lle32mha	168	6	deficiency	deficiency	NN
cord-270469-lle32mha	168	7	decreases	decrease	VBZ
cord-270469-lle32mha	168	8	viability	viability	NN
cord-270469-lle32mha	168	9	,	,	,
cord-270469-lle32mha	168	10	possibly	possibly	RB
cord-270469-lle32mha	168	11	due	due	IN
cord-270469-lle32mha	168	12	to	to	IN
cord-270469-lle32mha	168	13	a	a	DT
cord-270469-lle32mha	168	14	reduced	reduce	VBN
cord-270469-lle32mha	168	15	ability	ability	NN
cord-270469-lle32mha	168	16	to	to	TO
cord-270469-lle32mha	168	17	cope	cope	VB
cord-270469-lle32mha	168	18	with	with	IN
cord-270469-lle32mha	168	19	loss	loss	NN
cord-270469-lle32mha	168	20	of	of	IN
cord-270469-lle32mha	168	21	ER	er	NN
cord-270469-lle32mha	168	22	-	-	HYPH
cord-270469-lle32mha	168	23	homeostasis	homeostasis	NN
cord-270469-lle32mha	168	24	in	in	IN
cord-270469-lle32mha	168	25	these	these	DT
cord-270469-lle32mha	168	26	worms	worm	NNS
cord-270469-lle32mha	168	27	[	[	-LRB-
cord-270469-lle32mha	168	28	49	49	CD
cord-270469-lle32mha	168	29	]	]	-RRB-
cord-270469-lle32mha	168	30	.	.	.
cord-270469-lle32mha	169	1	Several	several	JJ
cord-270469-lle32mha	169	2	types	type	NNS
cord-270469-lle32mha	169	3	of	of	IN
cord-270469-lle32mha	169	4	virus	virus	NN
cord-270469-lle32mha	169	5	,	,	,
cord-270469-lle32mha	169	6	parasite	parasite	NN
cord-270469-lle32mha	169	7	and	and	CC
cord-270469-lle32mha	169	8	bacterium	bacterium	NN
cord-270469-lle32mha	169	9	that	that	WDT
cord-270469-lle32mha	169	10	infect	infect	VBP
cord-270469-lle32mha	169	11	humans	human	NNS
cord-270469-lle32mha	169	12	have	have	VBP
cord-270469-lle32mha	169	13	been	be	VBN
cord-270469-lle32mha	169	14	shown	show	VBN
cord-270469-lle32mha	169	15	to	to	TO
cord-270469-lle32mha	169	16	perturb	perturb	VB
cord-270469-lle32mha	169	17	the	the	DT
cord-270469-lle32mha	169	18	ER	er	NN
cord-270469-lle32mha	169	19	and	and	CC
cord-270469-lle32mha	169	20	to	to	TO
cord-270469-lle32mha	169	21	manipulate	manipulate	VB
cord-270469-lle32mha	169	22	ER	ER	NNP
cord-270469-lle32mha	169	23	-	-	HYPH
cord-270469-lle32mha	169	24	signaling	signal	VBG
cord-270469-lle32mha	169	25	pathways	pathway	NNS
cord-270469-lle32mha	169	26	as	as	IN
cord-270469-lle32mha	169	27	a	a	DT
cord-270469-lle32mha	169	28	mechanism	mechanism	NN
cord-270469-lle32mha	169	29	aimed	aim	VBN
cord-270469-lle32mha	169	30	at	at	IN
cord-270469-lle32mha	169	31	interfering	interfere	VBG
cord-270469-lle32mha	169	32	with	with	IN
cord-270469-lle32mha	169	33	host	host	NN
cord-270469-lle32mha	169	34	immune	immune	JJ
cord-270469-lle32mha	169	35	responses	response	NNS
cord-270469-lle32mha	169	36	and	and	CC
cord-270469-lle32mha	169	37	supporting	support	VBG
cord-270469-lle32mha	169	38	replication	replication	NN
cord-270469-lle32mha	169	39	.	.	.
cord-270469-lle32mha	170	1	Viruses	virus	NNS
cord-270469-lle32mha	170	2	are	be	VBP
cord-270469-lle32mha	170	3	obligate	obligate	VBN
cord-270469-lle32mha	170	4	intracellular	intracellular	JJ
cord-270469-lle32mha	170	5	pathogens	pathogen	NNS
cord-270469-lle32mha	170	6	that	that	WDT
cord-270469-lle32mha	170	7	depend	depend	VBP
cord-270469-lle32mha	170	8	on	on	IN
cord-270469-lle32mha	170	9	the	the	DT
cord-270469-lle32mha	170	10	host	host	NN
cord-270469-lle32mha	170	11	machinery	machinery	NN
cord-270469-lle32mha	170	12	to	to	TO
cord-270469-lle32mha	170	13	produce	produce	VB
cord-270469-lle32mha	170	14	large	large	JJ
cord-270469-lle32mha	170	15	amounts	amount	NNS
cord-270469-lle32mha	170	16	of	of	IN
cord-270469-lle32mha	170	17	infectious	infectious	JJ
cord-270469-lle32mha	170	18	viral	viral	JJ
cord-270469-lle32mha	170	19	particles	particle	NNS
cord-270469-lle32mha	170	20	.	.	.
cord-270469-lle32mha	171	1	Many	many	JJ
cord-270469-lle32mha	171	2	viruses	virus	NNS
cord-270469-lle32mha	171	3	depend	depend	VBP
cord-270469-lle32mha	171	4	on	on	IN
cord-270469-lle32mha	171	5	ER	ER	NNP
cord-270469-lle32mha	171	6	-	-	HYPH
cord-270469-lle32mha	171	7	membranes	membrane	NNS
cord-270469-lle32mha	171	8	for	for	IN
cord-270469-lle32mha	171	9	translation	translation	NN
cord-270469-lle32mha	171	10	and	and	CC
cord-270469-lle32mha	171	11	budding	budding	NN
cord-270469-lle32mha	171	12	of	of	IN
cord-270469-lle32mha	171	13	viral	viral	JJ
cord-270469-lle32mha	171	14	particles	particle	NNS
cord-270469-lle32mha	171	15	,	,	,
cord-270469-lle32mha	171	16	a	a	DT
cord-270469-lle32mha	171	17	process	process	NN
cord-270469-lle32mha	171	18	that	that	WDT
cord-270469-lle32mha	171	19	can	can	MD
cord-270469-lle32mha	171	20	result	result	VB
cord-270469-lle32mha	171	21	in	in	IN
cord-270469-lle32mha	171	22	the	the	DT
cord-270469-lle32mha	171	23	alteration	alteration	NN
cord-270469-lle32mha	171	24	of	of	IN
cord-270469-lle32mha	171	25	ER	er	NN
cord-270469-lle32mha	171	26	-	-	HYPH
cord-270469-lle32mha	171	27	homeostasis	homeostasis	NN
cord-270469-lle32mha	171	28	and	and	CC
cord-270469-lle32mha	171	29	therefore	therefore	RB
cord-270469-lle32mha	171	30	affect	affect	VBP
cord-270469-lle32mha	171	31	immune	immune	JJ
cord-270469-lle32mha	171	32	responses	response	NNS
cord-270469-lle32mha	171	33	[	[	-LRB-
cord-270469-lle32mha	171	34	50	50	CD
cord-270469-lle32mha	171	35	]	]	-RRB-
cord-270469-lle32mha	171	36	.	.	.
cord-270469-lle32mha	172	1	In	in	IN
cord-270469-lle32mha	172	2	humans	human	NNS
cord-270469-lle32mha	172	3	,	,	,
cord-270469-lle32mha	172	4	ER	er	NN
cord-270469-lle32mha	172	5	-	-	HYPH
cord-270469-lle32mha	172	6	stress	stress	NN
cord-270469-lle32mha	172	7	was	be	VBD
cord-270469-lle32mha	172	8	detected	detect	VBN
cord-270469-lle32mha	172	9	in	in	IN
cord-270469-lle32mha	172	10	tissues	tissue	NNS
cord-270469-lle32mha	172	11	infected	infect	VBN
cord-270469-lle32mha	172	12	with	with	IN
cord-270469-lle32mha	172	13	different	different	JJ
cord-270469-lle32mha	172	14	viruses	virus	NNS
cord-270469-lle32mha	172	15	.	.	.
cord-270469-lle32mha	173	1	For	for	IN
cord-270469-lle32mha	173	2	example	example	NN
cord-270469-lle32mha	173	3	,	,	,
cord-270469-lle32mha	173	4	XBP1	XBP1	NNP
cord-270469-lle32mha	173	5	splicing	splicing	NN
cord-270469-lle32mha	173	6	and	and	CC
cord-270469-lle32mha	173	7	CHOP	chop	NN
cord-270469-lle32mha	173	8	upregulation	upregulation	NN
cord-270469-lle32mha	173	9	was	be	VBD
cord-270469-lle32mha	173	10	detected	detect	VBN
cord-270469-lle32mha	173	11	in	in	IN
cord-270469-lle32mha	173	12	duodenal	duodenal	JJ
cord-270469-lle32mha	173	13	biopsies	biopsy	NNS
cord-270469-lle32mha	173	14	from	from	IN
cord-270469-lle32mha	173	15	individuals	individual	NNS
cord-270469-lle32mha	173	16	infected	infect	VBN
cord-270469-lle32mha	173	17	with	with	IN
cord-270469-lle32mha	173	18	HIV	HIV	NNP
cord-270469-lle32mha	173	19	compared	compare	VBN
cord-270469-lle32mha	173	20	to	to	IN
cord-270469-lle32mha	173	21	uninfected	uninfected	JJ
cord-270469-lle32mha	173	22	persons	person	NNS
cord-270469-lle32mha	173	23	[	[	-LRB-
cord-270469-lle32mha	173	24	51	51	CD
cord-270469-lle32mha	173	25	]	]	-RRB-
cord-270469-lle32mha	173	26	.	.	.
cord-270469-lle32mha	174	1	ER	er	NN
cord-270469-lle32mha	174	2	-	-	HYPH
cord-270469-lle32mha	174	3	stress	stress	NN
cord-270469-lle32mha	174	4	was	be	VBD
cord-270469-lle32mha	174	5	also	also	RB
cord-270469-lle32mha	174	6	observed	observe	VBN
cord-270469-lle32mha	174	7	in	in	IN
cord-270469-lle32mha	174	8	the	the	DT
cord-270469-lle32mha	174	9	liver	liver	NN
cord-270469-lle32mha	174	10	of	of	IN
cord-270469-lle32mha	174	11	patients	patient	NNS
cord-270469-lle32mha	174	12	with	with	IN
cord-270469-lle32mha	174	13	chronic	chronic	JJ
cord-270469-lle32mha	174	14	hepatitis	hepatitis	NN
cord-270469-lle32mha	174	15	C	C	NNP
cord-270469-lle32mha	174	16	(	(	-LRB-
cord-270469-lle32mha	174	17	HCV	HCV	NNP
cord-270469-lle32mha	174	18	)	)	-RRB-
cord-270469-lle32mha	174	19	[	[	-LRB-
cord-270469-lle32mha	174	20	52	52	CD
cord-270469-lle32mha	174	21	]	]	-RRB-
cord-270469-lle32mha	174	22	.	.	.
cord-270469-lle32mha	175	1	Parasites	parasite	NNS
cord-270469-lle32mha	175	2	such	such	JJ
cord-270469-lle32mha	175	3	as	as	IN
cord-270469-lle32mha	175	4	Toxoplasma	Toxoplasma	NNP
cord-270469-lle32mha	175	5	gondii	gondii	NN
cord-270469-lle32mha	175	6	activate	activate	VBP
cord-270469-lle32mha	175	7	the	the	DT
cord-270469-lle32mha	175	8	ER	er	NN
cord-270469-lle32mha	175	9	-	-	HYPH
cord-270469-lle32mha	175	10	stress	stress	NN
cord-270469-lle32mha	175	11	response	response	NN
cord-270469-lle32mha	175	12	[	[	-LRB-
cord-270469-lle32mha	175	13	53	53	CD
cord-270469-lle32mha	175	14	]	]	-RRB-
cord-270469-lle32mha	175	15	.	.	.
cord-270469-lle32mha	176	1	Loss	loss	NN
cord-270469-lle32mha	176	2	of	of	IN
cord-270469-lle32mha	176	3	ER	er	NN
cord-270469-lle32mha	176	4	-	-	HYPH
cord-270469-lle32mha	176	5	homeostasis	homeostasis	NN
cord-270469-lle32mha	176	6	was	be	VBD
cord-270469-lle32mha	176	7	also	also	RB
cord-270469-lle32mha	176	8	observed	observe	VBN
cord-270469-lle32mha	176	9	upon	upon	IN
cord-270469-lle32mha	176	10	infection	infection	NN
cord-270469-lle32mha	176	11	with	with	IN
cord-270469-lle32mha	176	12	different	different	JJ
cord-270469-lle32mha	176	13	bacteria	bacteria	NNS
cord-270469-lle32mha	176	14	.	.	.
cord-270469-lle32mha	177	1	CHOP	CHOP	NNP
cord-270469-lle32mha	177	2	induction	induction	NN
cord-270469-lle32mha	177	3	,	,	,
cord-270469-lle32mha	177	4	EIF2a	EIF2a	NNP
cord-270469-lle32mha	177	5	phosphorylated	phosphorylated	JJ
cord-270469-lle32mha	177	6	and	and	CC
cord-270469-lle32mha	177	7	IRE1	IRE1	NNP
cord-270469-lle32mha	177	8	activation	activation	NN
cord-270469-lle32mha	177	9	was	be	VBD
cord-270469-lle32mha	177	10	observed	observe	VBN
cord-270469-lle32mha	177	11	in	in	IN
cord-270469-lle32mha	177	12	macrophagerich	macrophagerich	JJ
cord-270469-lle32mha	177	13	areas	area	NNS
cord-270469-lle32mha	177	14	of	of	IN
cord-270469-lle32mha	177	15	granulomas	granuloma	NNS
cord-270469-lle32mha	177	16	in	in	IN
cord-270469-lle32mha	177	17	lungs	lung	NNS
cord-270469-lle32mha	177	18	of	of	IN
cord-270469-lle32mha	177	19	mice	mouse	NNS
cord-270469-lle32mha	177	20	infected	infect	VBN
cord-270469-lle32mha	177	21	with	with	IN
cord-270469-lle32mha	177	22	virulent	virulent	JJ
cord-270469-lle32mha	177	23	Mycobacterium	Mycobacterium	NNP
cord-270469-lle32mha	177	24	tuberculosis	tuberculosis	NN
cord-270469-lle32mha	177	25	(	(	-LRB-
cord-270469-lle32mha	177	26	Mtb	Mtb	NNP
cord-270469-lle32mha	177	27	)	)	-RRB-
cord-270469-lle32mha	177	28	[	[	-LRB-
cord-270469-lle32mha	177	29	54	54	CD
cord-270469-lle32mha	177	30	]	]	-RRB-
cord-270469-lle32mha	177	31	.	.	.
cord-270469-lle32mha	178	1	ER	ER	NNP
cord-270469-lle32mha	178	2	-	-	HYPH
cord-270469-lle32mha	178	3	stress	stress	NN
cord-270469-lle32mha	178	4	activation	activation	NN
cord-270469-lle32mha	178	5	by	by	IN
cord-270469-lle32mha	178	6	live	live	JJ
cord-270469-lle32mha	178	7	bacteria	bacteria	NNS
cord-270469-lle32mha	178	8	can	can	MD
cord-270469-lle32mha	178	9	also	also	RB
cord-270469-lle32mha	178	10	occur	occur	VB
cord-270469-lle32mha	178	11	prior	prior	RB
cord-270469-lle32mha	178	12	to	to	IN
cord-270469-lle32mha	178	13	cell	cell	NN
cord-270469-lle32mha	178	14	host	host	NN
cord-270469-lle32mha	178	15	invasion	invasion	NN
cord-270469-lle32mha	178	16	.	.	.
cord-270469-lle32mha	179	1	The	the	DT
cord-270469-lle32mha	179	2	facultative	facultative	JJ
cord-270469-lle32mha	179	3	intracellular	intracellular	JJ
cord-270469-lle32mha	179	4	pathogen	pathogen	NN
cord-270469-lle32mha	179	5	Listeria	Listeria	NNP
cord-270469-lle32mha	179	6	monocytogenes	monocytogenes	NNP
cord-270469-lle32mha	179	7	(	(	-LRB-
cord-270469-lle32mha	179	8	Lm	Lm	NNP
cord-270469-lle32mha	179	9	)	)	-RRB-
cord-270469-lle32mha	179	10	was	be	VBD
cord-270469-lle32mha	179	11	found	find	VBN
cord-270469-lle32mha	179	12	to	to	TO
cord-270469-lle32mha	179	13	induce	induce	VB
cord-270469-lle32mha	179	14	ER	ER	NNP
cord-270469-lle32mha	179	15	expansion	expansion	NN
cord-270469-lle32mha	179	16	and	and	CC
cord-270469-lle32mha	179	17	ERstress	ERstress	NNP
cord-270469-lle32mha	179	18	signaling	signal	VBG
cord-270469-lle32mha	179	19	pathways	pathway	NNS
cord-270469-lle32mha	179	20	prior	prior	RB
cord-270469-lle32mha	179	21	to	to	IN
cord-270469-lle32mha	179	22	host	host	NN
cord-270469-lle32mha	179	23	cell	cell	NN
cord-270469-lle32mha	179	24	entry	entry	NN
cord-270469-lle32mha	179	25	[	[	-LRB-
cord-270469-lle32mha	179	26	55	55	CD
cord-270469-lle32mha	179	27	]	]	-RRB-
cord-270469-lle32mha	179	28	.	.	.
cord-270469-lle32mha	180	1	The	the	DT
cord-270469-lle32mha	180	2	monitoring	monitoring	NN
cord-270469-lle32mha	180	3	of	of	IN
cord-270469-lle32mha	180	4	genes	gene	NNS
cord-270469-lle32mha	180	5	typically	typically	RB
cord-270469-lle32mha	180	6	associated	associate	VBN
cord-270469-lle32mha	180	7	with	with	IN
cord-270469-lle32mha	180	8	ERstress	erstress	JJ
cord-270469-lle32mha	180	9	responses	response	NNS
cord-270469-lle32mha	180	10	is	be	VBZ
cord-270469-lle32mha	180	11	the	the	DT
cord-270469-lle32mha	180	12	main	main	JJ
cord-270469-lle32mha	180	13	feature	feature	NN
cord-270469-lle32mha	180	14	used	use	VBN
cord-270469-lle32mha	180	15	to	to	TO
cord-270469-lle32mha	180	16	identify	identify	VB
cord-270469-lle32mha	180	17	the	the	DT
cord-270469-lle32mha	180	18	activation	activation	NN
cord-270469-lle32mha	180	19	of	of	IN
cord-270469-lle32mha	180	20	ER	er	NN
cord-270469-lle32mha	180	21	-	-	HYPH
cord-270469-lle32mha	180	22	signaling	signal	VBG
cord-270469-lle32mha	180	23	pathways	pathway	NNS
cord-270469-lle32mha	180	24	.	.	.
cord-270469-lle32mha	181	1	However	however	RB
cord-270469-lle32mha	181	2	recent	recent	JJ
cord-270469-lle32mha	181	3	studies	study	NNS
cord-270469-lle32mha	181	4	demonstrate	demonstrate	VBP
cord-270469-lle32mha	181	5	that	that	IN
cord-270469-lle32mha	181	6	pathogens	pathogen	NNS
cord-270469-lle32mha	181	7	can	can	MD
cord-270469-lle32mha	181	8	trigger	trigger	VB
cord-270469-lle32mha	181	9	a	a	DT
cord-270469-lle32mha	181	10	specific	specific	JJ
cord-270469-lle32mha	181	11	branch	branch	NN
cord-270469-lle32mha	181	12	of	of	IN
cord-270469-lle32mha	181	13	the	the	DT
cord-270469-lle32mha	181	14	ER	ER	NNP
cord-270469-lle32mha	181	15	-	-	HYPH
cord-270469-lle32mha	181	16	stress	stress	NN
cord-270469-lle32mha	181	17	program	program	NN
cord-270469-lle32mha	181	18	independently	independently	RB
cord-270469-lle32mha	181	19	of	of	IN
cord-270469-lle32mha	181	20	the	the	DT
cord-270469-lle32mha	181	21	other	other	JJ
cord-270469-lle32mha	181	22	branches	branch	NNS
cord-270469-lle32mha	181	23	without	without	IN
cord-270469-lle32mha	181	24	engaging	engage	VBG
cord-270469-lle32mha	181	25	a	a	DT
cord-270469-lle32mha	181	26	full	full	JJ
cord-270469-lle32mha	181	27	ER	er	NN
cord-270469-lle32mha	181	28	-	-	HYPH
cord-270469-lle32mha	181	29	stress	stress	NN
cord-270469-lle32mha	181	30	response	response	NN
cord-270469-lle32mha	181	31	and	and	CC
cord-270469-lle32mha	181	32	upregulating	upregulate	VBG
cord-270469-lle32mha	181	33	genes	gene	NNS
cord-270469-lle32mha	181	34	characteristic	characteristic	JJ
cord-270469-lle32mha	181	35	of	of	IN
cord-270469-lle32mha	181	36	ER	er	NN
cord-270469-lle32mha	181	37	-	-	HYPH
cord-270469-lle32mha	181	38	stress	stress	NN
cord-270469-lle32mha	181	39	responses	response	NNS
cord-270469-lle32mha	181	40	.	.	.
cord-270469-lle32mha	182	1	Influenza	Influenza	NNP
cord-270469-lle32mha	182	2	A	a	DT
cord-270469-lle32mha	182	3	virus	virus	NN
cord-270469-lle32mha	182	4	activates	activate	VBZ
cord-270469-lle32mha	182	5	the	the	DT
cord-270469-lle32mha	182	6	IRE1	IRE1	NNP
cord-270469-lle32mha	182	7	pathway	pathway	NN
cord-270469-lle32mha	182	8	with	with	IN
cord-270469-lle32mha	182	9	little	little	JJ
cord-270469-lle32mha	182	10	or	or	CC
cord-270469-lle32mha	182	11	no	no	DT
cord-270469-lle32mha	182	12	parallel	parallel	JJ
cord-270469-lle32mha	182	13	activation	activation	NN
cord-270469-lle32mha	182	14	of	of	IN
cord-270469-lle32mha	182	15	the	the	DT
cord-270469-lle32mha	182	16	PERK	perk	NN
cord-270469-lle32mha	182	17	and	and	CC
cord-270469-lle32mha	182	18	the	the	DT
cord-270469-lle32mha	182	19	ATF6	ATF6	NNP
cord-270469-lle32mha	182	20	pathways	pathway	NNS
cord-270469-lle32mha	182	21	.	.	.
cord-270469-lle32mha	183	1	IRE1	IRE1	NNP
cord-270469-lle32mha	183	2	activation	activation	NN
cord-270469-lle32mha	183	3	is	be	VBZ
cord-270469-lle32mha	183	4	apparently	apparently	RB
cord-270469-lle32mha	183	5	important	important	JJ
cord-270469-lle32mha	183	6	for	for	IN
cord-270469-lle32mha	183	7	viral	viral	JJ
cord-270469-lle32mha	183	8	replication	replication	NN
cord-270469-lle32mha	183	9	.	.	.
cord-270469-lle32mha	184	1	Inhibition	inhibition	NN
cord-270469-lle32mha	184	2	of	of	IN
cord-270469-lle32mha	184	3	IRE1	IRE1	NNP
cord-270469-lle32mha	184	4	blocked	block	VBD
cord-270469-lle32mha	184	5	Influenza	Influenza	NNP
cord-270469-lle32mha	184	6	A	a	DT
cord-270469-lle32mha	184	7	virus	virus	NN
cord-270469-lle32mha	184	8	replication	replication	NN
cord-270469-lle32mha	184	9	[	[	-LRB-
cord-270469-lle32mha	184	10	56	56	CD
cord-270469-lle32mha	184	11	]	]	-RRB-
cord-270469-lle32mha	184	12	,	,	,
cord-270469-lle32mha	184	13	demonstrating	demonstrate	VBG
cord-270469-lle32mha	184	14	that	that	IN
cord-270469-lle32mha	184	15	the	the	DT
cord-270469-lle32mha	184	16	virus	virus	NN
cord-270469-lle32mha	184	17	may	may	MD
cord-270469-lle32mha	184	18	manipulate	manipulate	VB
cord-270469-lle32mha	184	19	the	the	DT
cord-270469-lle32mha	184	20	IRE1	IRE1	NNP
cord-270469-lle32mha	184	21	and	and	CC
cord-270469-lle32mha	184	22	benefit	benefit	VB
cord-270469-lle32mha	184	23	from	from	IN
cord-270469-lle32mha	184	24	it	-PRON-	PRP
cord-270469-lle32mha	184	25	.	.	.
cord-270469-lle32mha	185	1	Acute	acute	JJ
cord-270469-lle32mha	185	2	infection	infection	NN
cord-270469-lle32mha	185	3	with	with	IN
cord-270469-lle32mha	185	4	lymphocytic	lymphocytic	JJ
cord-270469-lle32mha	185	5	choriomeningitis	choriomeningitis	NNP
cord-270469-lle32mha	185	6	virus	virus	NN
cord-270469-lle32mha	185	7	(	(	-LRB-
cord-270469-lle32mha	185	8	LCMV	LCMV	NNP
cord-270469-lle32mha	185	9	)	)	-RRB-
cord-270469-lle32mha	185	10	was	be	VBD
cord-270469-lle32mha	185	11	shown	show	VBN
cord-270469-lle32mha	185	12	to	to	TO
cord-270469-lle32mha	185	13	trigger	trigger	VB
cord-270469-lle32mha	185	14	a	a	DT
cord-270469-lle32mha	185	15	selective	selective	JJ
cord-270469-lle32mha	185	16	induction	induction	NN
cord-270469-lle32mha	185	17	of	of	IN
cord-270469-lle32mha	185	18	the	the	DT
cord-270469-lle32mha	185	19	ATF6regulated	ATF6regulated	NNP
cord-270469-lle32mha	185	20	branch	branch	NN
cord-270469-lle32mha	185	21	of	of	IN
cord-270469-lle32mha	185	22	the	the	DT
cord-270469-lle32mha	185	23	ER	ER	NNP
cord-270469-lle32mha	185	24	-	-	HYPH
cord-270469-lle32mha	185	25	stress	stress	NN
cord-270469-lle32mha	185	26	response	response	NN
cord-270469-lle32mha	185	27	,	,	,
cord-270469-lle32mha	185	28	whereas	whereas	IN
cord-270469-lle32mha	185	29	PERK	PERK	NNP
cord-270469-lle32mha	185	30	and	and	CC
cord-270469-lle32mha	185	31	IRE1	IRE1	NNP
cord-270469-lle32mha	185	32	pathways	pathway	NNS
cord-270469-lle32mha	185	33	are	be	VBP
cord-270469-lle32mha	185	34	neither	neither	CC
cord-270469-lle32mha	185	35	activated	activate	VBN
cord-270469-lle32mha	185	36	nor	nor	CC
cord-270469-lle32mha	185	37	blocked	block	VBN
cord-270469-lle32mha	185	38	[	[	-LRB-
cord-270469-lle32mha	185	39	57	57	CD
cord-270469-lle32mha	185	40	]	]	-RRB-
cord-270469-lle32mha	185	41	.	.	.
cord-270469-lle32mha	186	1	Fig	Fig	NNP
cord-270469-lle32mha	186	2	.	.	NNP
cord-270469-lle32mha	186	3	3	3	CD
cord-270469-lle32mha	186	4	.	.	.
cord-270469-lle32mha	187	1	TLR4	tlr4	JJ
cord-270469-lle32mha	187	2	responses	response	NNS
cord-270469-lle32mha	187	3	and	and	CC
cord-270469-lle32mha	187	4	ER	er	NN
cord-270469-lle32mha	187	5	-	-	HYPH
cord-270469-lle32mha	187	6	signaling	signaling	NN
cord-270469-lle32mha	187	7	are	be	VBP
cord-270469-lle32mha	187	8	connected	connect	VBN
cord-270469-lle32mha	187	9	and	and	CC
cord-270469-lle32mha	187	10	synergize	synergize	VB
cord-270469-lle32mha	187	11	to	to	TO
cord-270469-lle32mha	187	12	promote	promote	VB
cord-270469-lle32mha	187	13	cytokine	cytokine	NN
cord-270469-lle32mha	187	14	production	production	NN
cord-270469-lle32mha	187	15	.	.	.
cord-270469-lle32mha	188	1	TLR4	TLR4	NNP
cord-270469-lle32mha	188	2	activate	activate	VBP
cord-270469-lle32mha	188	3	the	the	DT
cord-270469-lle32mha	188	4	transcription	transcription	NN
cord-270469-lle32mha	188	5	factor	factor	NN
cord-270469-lle32mha	188	6	XBP1	XBP1	NNP
cord-270469-lle32mha	188	7	by	by	IN
cord-270469-lle32mha	188	8	selectively	selectively	RB
cord-270469-lle32mha	188	9	activating	activate	VBG
cord-270469-lle32mha	188	10	the	the	DT
cord-270469-lle32mha	188	11	IRE1	IRE1	NNP
cord-270469-lle32mha	188	12	kinase	kinase	NN
cord-270469-lle32mha	188	13	while	while	IN
cord-270469-lle32mha	188	14	decreasing	decrease	VBG
cord-270469-lle32mha	188	15	the	the	DT
cord-270469-lle32mha	188	16	activation	activation	NN
cord-270469-lle32mha	188	17	of	of	IN
cord-270469-lle32mha	188	18	ATF6	ATF6	NNP
cord-270469-lle32mha	188	19	and	and	CC
cord-270469-lle32mha	188	20	PERK	perk	VB
cord-270469-lle32mha	188	21	pathways	pathway	NNS
cord-270469-lle32mha	188	22	as	as	RB
cord-270469-lle32mha	188	23	well	well	RB
cord-270469-lle32mha	188	24	as	as	IN
cord-270469-lle32mha	188	25	ElF2a	elf2a	NN
cord-270469-lle32mha	188	26	activation	activation	NN
cord-270469-lle32mha	188	27	.	.	.
cord-270469-lle32mha	189	1	The	the	DT
cord-270469-lle32mha	189	2	activation	activation	NN
cord-270469-lle32mha	189	3	of	of	IN
cord-270469-lle32mha	189	4	IRE1	IRE1	NNP
cord-270469-lle32mha	189	5	and	and	CC
cord-270469-lle32mha	189	6	XBP1	XBP1	NNP
cord-270469-lle32mha	189	7	does	do	VBZ
cord-270469-lle32mha	189	8	not	not	RB
cord-270469-lle32mha	189	9	contribute	contribute	VB
cord-270469-lle32mha	189	10	to	to	IN
cord-270469-lle32mha	189	11	an	an	DT
cord-270469-lle32mha	189	12	ER	er	NN
cord-270469-lle32mha	189	13	-	-	HYPH
cord-270469-lle32mha	189	14	stress	stress	NN
cord-270469-lle32mha	189	15	response	response	NN
cord-270469-lle32mha	189	16	.	.	.
cord-270469-lle32mha	190	1	However	however	RB
cord-270469-lle32mha	190	2	,	,	,
cord-270469-lle32mha	190	3	activated	activate	VBD
cord-270469-lle32mha	190	4	XBP1	XBP1	NNP
cord-270469-lle32mha	190	5	amplifies	amplify	VBZ
cord-270469-lle32mha	190	6	TLR	TLR	NNP
cord-270469-lle32mha	190	7	signaling	signal	VBG
cord-270469-lle32mha	190	8	by	by	IN
cord-270469-lle32mha	190	9	enhancing	enhance	VBG
cord-270469-lle32mha	190	10	cytokine	cytokine	NN
cord-270469-lle32mha	190	11	production	production	NN
cord-270469-lle32mha	190	12	.	.	.
cord-270469-lle32mha	191	1	Similarly	similarly	RB
cord-270469-lle32mha	191	2	,	,	,
cord-270469-lle32mha	191	3	if	if	IN
cord-270469-lle32mha	191	4	CHOP	chop	NN
cord-270469-lle32mha	191	5	and	and	CC
cord-270469-lle32mha	191	6	XBP1	XBP1	NNP
cord-270469-lle32mha	191	7	are	be	VBP
cord-270469-lle32mha	191	8	induced	induce	VBN
cord-270469-lle32mha	191	9	upon	upon	IN
cord-270469-lle32mha	191	10	treatment	treatment	NN
cord-270469-lle32mha	191	11	with	with	IN
cord-270469-lle32mha	191	12	pharmacological	pharmacological	JJ
cord-270469-lle32mha	191	13	agents	agent	NNS
cord-270469-lle32mha	191	14	,	,	,
cord-270469-lle32mha	191	15	they	-PRON-	PRP
cord-270469-lle32mha	191	16	both	both	DT
cord-270469-lle32mha	191	17	may	may	MD
cord-270469-lle32mha	191	18	contribute	contribute	VB
cord-270469-lle32mha	191	19	to	to	IN
cord-270469-lle32mha	191	20	cytokine	cytokine	NN
cord-270469-lle32mha	191	21	production	production	NN
cord-270469-lle32mha	191	22	.	.	.
cord-270469-lle32mha	192	1	How	how	WRB
cord-270469-lle32mha	192	2	viruses	virus	NNS
cord-270469-lle32mha	192	3	trigger	trigger	VBP
cord-270469-lle32mha	192	4	specific	specific	JJ
cord-270469-lle32mha	192	5	ER	er	NN
cord-270469-lle32mha	192	6	-	-	HYPH
cord-270469-lle32mha	192	7	signaling	signal	VBG
cord-270469-lle32mha	192	8	pathways	pathway	NNS
cord-270469-lle32mha	192	9	is	be	VBZ
cord-270469-lle32mha	192	10	unclear	unclear	JJ
cord-270469-lle32mha	192	11	.	.	.
cord-270469-lle32mha	193	1	In	in	IN
cord-270469-lle32mha	193	2	the	the	DT
cord-270469-lle32mha	193	3	case	case	NN
cord-270469-lle32mha	193	4	of	of	IN
cord-270469-lle32mha	193	5	LCMV	LCMV	NNP
cord-270469-lle32mha	193	6	,	,	,
cord-270469-lle32mha	193	7	activation	activation	NN
cord-270469-lle32mha	193	8	of	of	IN
cord-270469-lle32mha	193	9	ATF6	ATF6	NNP
cord-270469-lle32mha	193	10	may	may	MD
cord-270469-lle32mha	193	11	involve	involve	VB
cord-270469-lle32mha	193	12	the	the	DT
cord-270469-lle32mha	193	13	viral	viral	JJ
cord-270469-lle32mha	193	14	glycoprotein	glycoprotein	NN
cord-270469-lle32mha	193	15	precursor	precursor	NN
cord-270469-lle32mha	193	16	(	(	-LRB-
cord-270469-lle32mha	193	17	GPC	GPC	NNP
cord-270469-lle32mha	193	18	)	)	-RRB-
cord-270469-lle32mha	193	19	[	[	-LRB-
cord-270469-lle32mha	193	20	57	57	CD
cord-270469-lle32mha	193	21	]	]	-RRB-
cord-270469-lle32mha	193	22	,	,	,
cord-270469-lle32mha	193	23	further	further	RB
cord-270469-lle32mha	193	24	suggesting	suggest	VBG
cord-270469-lle32mha	193	25	that	that	IN
cord-270469-lle32mha	193	26	some	some	DT
cord-270469-lle32mha	193	27	viruses	virus	NNS
cord-270469-lle32mha	193	28	may	may	MD
cord-270469-lle32mha	193	29	directly	directly	RB
cord-270469-lle32mha	193	30	regulate	regulate	VB
cord-270469-lle32mha	193	31	these	these	DT
cord-270469-lle32mha	193	32	pathways	pathway	NNS
cord-270469-lle32mha	193	33	independently	independently	RB
cord-270469-lle32mha	193	34	of	of	IN
cord-270469-lle32mha	193	35	the	the	DT
cord-270469-lle32mha	193	36	induction	induction	NN
cord-270469-lle32mha	193	37	of	of	IN
cord-270469-lle32mha	193	38	ER	er	NN
cord-270469-lle32mha	193	39	-	-	HYPH
cord-270469-lle32mha	193	40	stress	stress	NN
cord-270469-lle32mha	193	41	.	.	.
cord-270469-lle32mha	194	1	While	while	IN
cord-270469-lle32mha	194	2	many	many	JJ
cord-270469-lle32mha	194	3	pathogens	pathogen	NNS
cord-270469-lle32mha	194	4	trigger	trigger	VBP
cord-270469-lle32mha	194	5	ER	er	NN
cord-270469-lle32mha	194	6	-	-	HYPH
cord-270469-lle32mha	194	7	stress	stress	NN
cord-270469-lle32mha	194	8	and/or	and/or	CC
cord-270469-lle32mha	194	9	features	feature	VBZ
cord-270469-lle32mha	194	10	associated	associate	VBN
cord-270469-lle32mha	194	11	with	with	IN
cord-270469-lle32mha	194	12	the	the	DT
cord-270469-lle32mha	194	13	ER	er	NN
cord-270469-lle32mha	194	14	-	-	HYPH
cord-270469-lle32mha	194	15	stress	stress	NN
cord-270469-lle32mha	194	16	response	response	NN
cord-270469-lle32mha	194	17	,	,	,
cord-270469-lle32mha	194	18	the	the	DT
cord-270469-lle32mha	194	19	exact	exact	JJ
cord-270469-lle32mha	194	20	function	function	NN
cord-270469-lle32mha	194	21	of	of	IN
cord-270469-lle32mha	194	22	these	these	DT
cord-270469-lle32mha	194	23	pathways	pathway	NNS
cord-270469-lle32mha	194	24	are	be	VBP
cord-270469-lle32mha	194	25	still	still	RB
cord-270469-lle32mha	194	26	poorly	poorly	RB
cord-270469-lle32mha	194	27	understood	understand	VBN
cord-270469-lle32mha	194	28	.	.	.
cord-270469-lle32mha	195	1	Activation	activation	NN
cord-270469-lle32mha	195	2	of	of	IN
cord-270469-lle32mha	195	3	ERstress	ERstress	NNP
cord-270469-lle32mha	195	4	and	and	CC
cord-270469-lle32mha	195	5	ER	er	NN
cord-270469-lle32mha	195	6	-	-	HYPH
cord-270469-lle32mha	195	7	signaling	signal	VBG
cord-270469-lle32mha	195	8	pathways	pathway	NNS
cord-270469-lle32mha	195	9	may	may	MD
cord-270469-lle32mha	195	10	increase	increase	VB
cord-270469-lle32mha	195	11	immunity	immunity	NN
cord-270469-lle32mha	195	12	and	and	CC
cord-270469-lle32mha	195	13	reduce	reduce	VB
cord-270469-lle32mha	195	14	the	the	DT
cord-270469-lle32mha	195	15	cellular	cellular	JJ
cord-270469-lle32mha	195	16	stress	stress	NN
cord-270469-lle32mha	195	17	associated	associate	VBN
cord-270469-lle32mha	195	18	with	with	IN
cord-270469-lle32mha	195	19	the	the	DT
cord-270469-lle32mha	195	20	infection	infection	NN
cord-270469-lle32mha	195	21	.	.	.
cord-270469-lle32mha	196	1	This	this	DT
cord-270469-lle32mha	196	2	is	be	VBZ
cord-270469-lle32mha	196	3	a	a	DT
cord-270469-lle32mha	196	4	recent	recent	JJ
cord-270469-lle32mha	196	5	hypothesis	hypothesis	NN
cord-270469-lle32mha	196	6	and	and	CC
cord-270469-lle32mha	196	7	few	few	JJ
cord-270469-lle32mha	196	8	experimental	experimental	JJ
cord-270469-lle32mha	196	9	evidences	evidence	NNS
cord-270469-lle32mha	196	10	demonstrate	demonstrate	VBP
cord-270469-lle32mha	196	11	the	the	DT
cord-270469-lle32mha	196	12	physiological	physiological	JJ
cord-270469-lle32mha	196	13	importance	importance	NN
cord-270469-lle32mha	196	14	of	of	IN
cord-270469-lle32mha	196	15	these	these	DT
cord-270469-lle32mha	196	16	pathways	pathway	NNS
cord-270469-lle32mha	196	17	in	in	IN
cord-270469-lle32mha	196	18	regulating	regulate	VBG
cord-270469-lle32mha	196	19	pathogen	pathogen	NN
cord-270469-lle32mha	196	20	replication	replication	NN
cord-270469-lle32mha	196	21	and	and	CC
cord-270469-lle32mha	196	22	immunity	immunity	NN
cord-270469-lle32mha	196	23	in	in	IN
cord-270469-lle32mha	196	24	vivo	vivo	NN
cord-270469-lle32mha	196	25	.	.	.
cord-270469-lle32mha	197	1	Importantly	importantly	RB
cord-270469-lle32mha	197	2	,	,	,
cord-270469-lle32mha	197	3	the	the	DT
cord-270469-lle32mha	197	4	key	key	JJ
cord-270469-lle32mha	197	5	role	role	NN
cord-270469-lle32mha	197	6	of	of	IN
cord-270469-lle32mha	197	7	these	these	DT
cord-270469-lle32mha	197	8	pathways	pathway	NNS
cord-270469-lle32mha	197	9	is	be	VBZ
cord-270469-lle32mha	197	10	also	also	RB
cord-270469-lle32mha	197	11	highlighted	highlight	VBN
cord-270469-lle32mha	197	12	by	by	IN
cord-270469-lle32mha	197	13	the	the	DT
cord-270469-lle32mha	197	14	fact	fact	NN
cord-270469-lle32mha	197	15	that	that	IN
cord-270469-lle32mha	197	16	pathogen	pathogen	NN
cord-270469-lle32mha	197	17	have	have	VBP
cord-270469-lle32mha	197	18	evolved	evolve	VBN
cord-270469-lle32mha	197	19	mechanisms	mechanism	NNS
cord-270469-lle32mha	197	20	to	to	TO
cord-270469-lle32mha	197	21	manipulate	manipulate	VB
cord-270469-lle32mha	197	22	ER	ER	NNP
cord-270469-lle32mha	197	23	-	-	HYPH
cord-270469-lle32mha	197	24	signaling	signal	VBG
cord-270469-lle32mha	197	25	pathways	pathway	NNS
cord-270469-lle32mha	197	26	optimizing	optimize	VBG
cord-270469-lle32mha	197	27	survival	survival	NN
cord-270469-lle32mha	197	28	and	and	CC
cord-270469-lle32mha	197	29	replication	replication	NN
cord-270469-lle32mha	197	30	.	.	.
cord-270469-lle32mha	198	1	The	the	DT
cord-270469-lle32mha	198	2	role	role	NN
cord-270469-lle32mha	198	3	of	of	IN
cord-270469-lle32mha	198	4	the	the	DT
cord-270469-lle32mha	198	5	ER	er	NN
cord-270469-lle32mha	198	6	-	-	HYPH
cord-270469-lle32mha	198	7	stress	stress	NN
cord-270469-lle32mha	198	8	pathways	pathway	NNS
cord-270469-lle32mha	198	9	in	in	IN
cord-270469-lle32mha	198	10	shaping	shape	VBG
cord-270469-lle32mha	198	11	immunity	immunity	NN
cord-270469-lle32mha	198	12	is	be	VBZ
cord-270469-lle32mha	198	13	underscored	underscore	VBN
cord-270469-lle32mha	198	14	by	by	IN
cord-270469-lle32mha	198	15	the	the	DT
cord-270469-lle32mha	198	16	fact	fact	NN
cord-270469-lle32mha	198	17	that	that	IN
cord-270469-lle32mha	198	18	pathogens	pathogen	NNS
cord-270469-lle32mha	198	19	as	as	RB
cord-270469-lle32mha	198	20	well	well	RB
cord-270469-lle32mha	198	21	as	as	IN
cord-270469-lle32mha	198	22	innate	innate	JJ
cord-270469-lle32mha	198	23	immunity	immunity	NN
cord-270469-lle32mha	198	24	pathways	pathway	NNS
cord-270469-lle32mha	198	25	regulate	regulate	VBP
cord-270469-lle32mha	198	26	ER	ER	NNP
cord-270469-lle32mha	198	27	-	-	HYPH
cord-270469-lle32mha	198	28	stress	stress	NN
cord-270469-lle32mha	198	29	responses	response	NNS
cord-270469-lle32mha	198	30	.	.	.
cord-270469-lle32mha	199	1	It	-PRON-	PRP
cord-270469-lle32mha	199	2	has	have	VBZ
cord-270469-lle32mha	199	3	been	be	VBN
cord-270469-lle32mha	199	4	shown	show	VBN
cord-270469-lle32mha	199	5	for	for	IN
cord-270469-lle32mha	199	6	example	example	NN
cord-270469-lle32mha	199	7	that	that	IN
cord-270469-lle32mha	199	8	the	the	DT
cord-270469-lle32mha	199	9	ATF4-CHOP	atf4-chop	CD
cord-270469-lle32mha	199	10	branch	branch	NN
cord-270469-lle32mha	199	11	of	of	IN
cord-270469-lle32mha	199	12	the	the	DT
cord-270469-lle32mha	199	13	PERK	PERK	NNP
cord-270469-lle32mha	199	14	pathway	pathway	NN
cord-270469-lle32mha	199	15	is	be	VBZ
cord-270469-lle32mha	199	16	specifically	specifically	RB
cord-270469-lle32mha	199	17	inhibited	inhibit	VBN
cord-270469-lle32mha	199	18	by	by	IN
cord-270469-lle32mha	199	19	TLR	TLR	NNP
cord-270469-lle32mha	199	20	signaling	signal	VBG
cord-270469-lle32mha	199	21	[	[	-LRB-
cord-270469-lle32mha	199	22	58	58	CD
cord-270469-lle32mha	199	23	]	]	-RRB-
cord-270469-lle32mha	199	24	.	.	.
cord-270469-lle32mha	200	1	Activation	activation	NN
cord-270469-lle32mha	200	2	of	of	IN
cord-270469-lle32mha	200	3	TRIF	TRIF	NNP
cord-270469-lle32mha	200	4	by	by	IN
cord-270469-lle32mha	200	5	TLRs	TLRs	NNP
cord-270469-lle32mha	200	6	activates	activate	VBZ
cord-270469-lle32mha	200	7	a	a	DT
cord-270469-lle32mha	200	8	phosphatase	phosphatase	NN
cord-270469-lle32mha	200	9	,	,	,
cord-270469-lle32mha	200	10	PP2A	PP2A	NNP
cord-270469-lle32mha	200	11	,	,	,
cord-270469-lle32mha	200	12	that	that	WDT
cord-270469-lle32mha	200	13	dephosphorylate	dephosphorylate	VBP
cord-270469-lle32mha	200	14	a	a	DT
cord-270469-lle32mha	200	15	subunit	subunit	NN
cord-270469-lle32mha	200	16	of	of	IN
cord-270469-lle32mha	200	17	EIF2B	eif2b	CD
cord-270469-lle32mha	200	18	(	(	-LRB-
cord-270469-lle32mha	200	19	guanine	guanine	NNP
cord-270469-lle32mha	200	20	nucleotide	nucleotide	JJ
cord-270469-lle32mha	200	21	exchange	exchange	NN
cord-270469-lle32mha	200	22	factor	factor	NN
cord-270469-lle32mha	200	23	for	for	IN
cord-270469-lle32mha	200	24	EIF2a	EIF2a	NNP
cord-270469-lle32mha	200	25	)	)	-RRB-
cord-270469-lle32mha	200	26	leading	lead	VBG
cord-270469-lle32mha	200	27	to	to	IN
cord-270469-lle32mha	200	28	the	the	DT
cord-270469-lle32mha	200	29	inhibition	inhibition	NN
cord-270469-lle32mha	200	30	of	of	IN
cord-270469-lle32mha	200	31	phosphorylated	phosphorylated	JJ
cord-270469-lle32mha	200	32	EIF2a	eif2a	JJ
cord-270469-lle32mha	200	33	activity	activity	NN
cord-270469-lle32mha	200	34	and	and	CC
cord-270469-lle32mha	200	35	downregulation	downregulation	NN
cord-270469-lle32mha	200	36	of	of	IN
cord-270469-lle32mha	200	37	PERK	perk	NN
cord-270469-lle32mha	200	38	mediated	mediate	VBN
cord-270469-lle32mha	200	39	ATF4	ATF4	NNP
cord-270469-lle32mha	200	40	and	and	CC
cord-270469-lle32mha	200	41	CHOP	chop	VB
cord-270469-lle32mha	200	42	upregulation	upregulation	NN
cord-270469-lle32mha	200	43	[	[	-LRB-
cord-270469-lle32mha	200	44	59	59	CD
cord-270469-lle32mha	200	45	]	]	-RRB-
cord-270469-lle32mha	200	46	.	.	.
cord-270469-lle32mha	201	1	In	in	IN
cord-270469-lle32mha	201	2	macrophages	macrophage	NNS
cord-270469-lle32mha	201	3	TLR	TLR	NNP
cord-270469-lle32mha	201	4	signaling	signaling	NN
cord-270469-lle32mha	201	5	has	have	VBZ
cord-270469-lle32mha	201	6	been	be	VBN
cord-270469-lle32mha	201	7	found	find	VBN
cord-270469-lle32mha	201	8	to	to	TO
cord-270469-lle32mha	201	9	inhibit	inhibit	VB
cord-270469-lle32mha	201	10	ATF6	ATF6	NNP
cord-270469-lle32mha	201	11	and	and	CC
cord-270469-lle32mha	201	12	PERK	PERK	NNP
cord-270469-lle32mha	201	13	activation	activation	NN
cord-270469-lle32mha	201	14	by	by	IN
cord-270469-lle32mha	201	15	a	a	DT
cord-270469-lle32mha	201	16	mechanism	mechanism	NN
cord-270469-lle32mha	201	17	yet	yet	RB
cord-270469-lle32mha	201	18	to	to	TO
cord-270469-lle32mha	201	19	be	be	VB
cord-270469-lle32mha	201	20	identified	identify	VBN
cord-270469-lle32mha	201	21	[	[	-LRB-
cord-270469-lle32mha	201	22	16	16	CD
cord-270469-lle32mha	201	23	]	]	-RRB-
cord-270469-lle32mha	201	24	.	.	.
cord-270469-lle32mha	202	1	This	this	DT
cord-270469-lle32mha	202	2	regulation	regulation	NN
cord-270469-lle32mha	202	3	of	of	IN
cord-270469-lle32mha	202	4	ER	er	NN
cord-270469-lle32mha	202	5	-	-	HYPH
cord-270469-lle32mha	202	6	signaling	signal	VBG
cord-270469-lle32mha	202	7	responses	response	NNS
cord-270469-lle32mha	202	8	by	by	IN
cord-270469-lle32mha	202	9	innate	innate	JJ
cord-270469-lle32mha	202	10	immunity	immunity	NN
cord-270469-lle32mha	202	11	may	may	MD
cord-270469-lle32mha	202	12	explain	explain	VB
cord-270469-lle32mha	202	13	why	why	WRB
cord-270469-lle32mha	202	14	TLRs	TLRs	NNP
cord-270469-lle32mha	202	15	in	in	IN
cord-270469-lle32mha	202	16	macrophages	macrophage	NNS
cord-270469-lle32mha	202	17	only	only	RB
cord-270469-lle32mha	202	18	activate	activate	VBP
cord-270469-lle32mha	202	19	IRE1	IRE1	NNP
cord-270469-lle32mha	202	20	and	and	CC
cord-270469-lle32mha	202	21	in	in	IN
cord-270469-lle32mha	202	22	absence	absence	NN
cord-270469-lle32mha	202	23	of	of	IN
cord-270469-lle32mha	202	24	concomitant	concomitant	JJ
cord-270469-lle32mha	202	25	activation	activation	NN
cord-270469-lle32mha	202	26	of	of	IN
cord-270469-lle32mha	202	27	PERK	PERK	NNP
cord-270469-lle32mha	202	28	and	and	CC
cord-270469-lle32mha	202	29	ATF6	ATF6	NNP
cord-270469-lle32mha	202	30	,	,	,
cord-270469-lle32mha	202	31	therefore	therefore	RB
cord-270469-lle32mha	202	32	,	,	,
cord-270469-lle32mha	202	33	favoring	favor	VBG
cord-270469-lle32mha	202	34	an	an	DT
cord-270469-lle32mha	202	35	inflammatory	inflammatory	JJ
cord-270469-lle32mha	202	36	response	response	NN
cord-270469-lle32mha	202	37	rather	rather	RB
cord-270469-lle32mha	202	38	than	than	IN
cord-270469-lle32mha	202	39	a	a	DT
cord-270469-lle32mha	202	40	full	full	JJ
cord-270469-lle32mha	202	41	ER	er	NN
cord-270469-lle32mha	202	42	-	-	HYPH
cord-270469-lle32mha	202	43	stress	stress	NN
cord-270469-lle32mha	202	44	response	response	NN
cord-270469-lle32mha	202	45	.	.	.
cord-270469-lle32mha	203	1	Viruses	virus	NNS
cord-270469-lle32mha	203	2	are	be	VBP
cord-270469-lle32mha	203	3	also	also	RB
cord-270469-lle32mha	203	4	able	able	JJ
cord-270469-lle32mha	203	5	to	to	TO
cord-270469-lle32mha	203	6	manipulate	manipulate	VB
cord-270469-lle32mha	203	7	the	the	DT
cord-270469-lle32mha	203	8	ER	er	NN
cord-270469-lle32mha	203	9	-	-	HYPH
cord-270469-lle32mha	203	10	stress	stress	NN
cord-270469-lle32mha	203	11	response	response	NN
cord-270469-lle32mha	203	12	by	by	IN
cord-270469-lle32mha	203	13	altering	alter	VBG
cord-270469-lle32mha	203	14	specific	specific	JJ
cord-270469-lle32mha	203	15	pathways	pathway	NNS
cord-270469-lle32mha	203	16	or	or	CC
cord-270469-lle32mha	203	17	changing	change	VBG
cord-270469-lle32mha	203	18	cellular	cellular	JJ
cord-270469-lle32mha	203	19	homeostatic	homeostatic	JJ
cord-270469-lle32mha	203	20	setpoints	setpoint	NNS
cord-270469-lle32mha	203	21	.	.	.
cord-270469-lle32mha	204	1	Dengue	dengue	NN
cord-270469-lle32mha	204	2	fever	fever	NN
cord-270469-lle32mha	204	3	virus	virus	NN
cord-270469-lle32mha	204	4	(	(	-LRB-
cord-270469-lle32mha	204	5	DENV	DENV	NNP
cord-270469-lle32mha	204	6	)	)	-RRB-
cord-270469-lle32mha	204	7	for	for	IN
cord-270469-lle32mha	204	8	example	example	NN
cord-270469-lle32mha	204	9	,	,	,
cord-270469-lle32mha	204	10	manipulates	manipulate	VBZ
cord-270469-lle32mha	204	11	the	the	DT
cord-270469-lle32mha	204	12	ER	ER	NNP
cord-270469-lle32mha	204	13	-	-	HYPH
cord-270469-lle32mha	204	14	signaling	signal	VBG
cord-270469-lle32mha	204	15	pathways	pathway	NNS
cord-270469-lle32mha	204	16	to	to	TO
cord-270469-lle32mha	204	17	specifically	specifically	RB
cord-270469-lle32mha	204	18	activate	activate	VB
cord-270469-lle32mha	204	19	and	and	CC
cord-270469-lle32mha	204	20	suppress	suppress	VB
cord-270469-lle32mha	204	21	the	the	DT
cord-270469-lle32mha	204	22	three	three	CD
cord-270469-lle32mha	204	23	different	different	JJ
cord-270469-lle32mha	204	24	branches	branch	NNS
cord-270469-lle32mha	204	25	of	of	IN
cord-270469-lle32mha	204	26	the	the	DT
cord-270469-lle32mha	204	27	ER	er	NN
cord-270469-lle32mha	204	28	-	-	HYPH
cord-270469-lle32mha	204	29	stress	stress	NN
cord-270469-lle32mha	204	30	response	response	NN
cord-270469-lle32mha	204	31	.	.	.
cord-270469-lle32mha	205	1	Importantly	importantly	RB
cord-270469-lle32mha	205	2	each	each	DT
cord-270469-lle32mha	205	3	branch	branch	NN
cord-270469-lle32mha	205	4	is	be	VBZ
cord-270469-lle32mha	205	5	regulated	regulate	VBN
cord-270469-lle32mha	205	6	differently	differently	RB
cord-270469-lle32mha	205	7	depending	depend	VBG
cord-270469-lle32mha	205	8	on	on	IN
cord-270469-lle32mha	205	9	timing	timing	NN
cord-270469-lle32mha	205	10	and	and	CC
cord-270469-lle32mha	205	11	the	the	DT
cord-270469-lle32mha	205	12	infectious	infectious	JJ
cord-270469-lle32mha	205	13	stage	stage	NN
cord-270469-lle32mha	205	14	[	[	-LRB-
cord-270469-lle32mha	205	15	60	60	CD
cord-270469-lle32mha	205	16	]	]	-RRB-
cord-270469-lle32mha	205	17	,	,	,
cord-270469-lle32mha	205	18	suggesting	suggest	VBG
cord-270469-lle32mha	205	19	that	that	IN
cord-270469-lle32mha	205	20	the	the	DT
cord-270469-lle32mha	205	21	virus	virus	NN
cord-270469-lle32mha	205	22	can	can	MD
cord-270469-lle32mha	205	23	specifically	specifically	RB
cord-270469-lle32mha	205	24	manipulate	manipulate	VB
cord-270469-lle32mha	205	25	the	the	DT
cord-270469-lle32mha	205	26	system	system	NN
cord-270469-lle32mha	205	27	to	to	TO
cord-270469-lle32mha	205	28	increase	increase	VB
cord-270469-lle32mha	205	29	survival	survival	NN
cord-270469-lle32mha	205	30	and	and	CC
cord-270469-lle32mha	205	31	prolong	prolong	VB
cord-270469-lle32mha	205	32	the	the	DT
cord-270469-lle32mha	205	33	viral	viral	JJ
cord-270469-lle32mha	205	34	life	life	NN
cord-270469-lle32mha	205	35	cycle	cycle	NN
cord-270469-lle32mha	205	36	.	.	.
cord-270469-lle32mha	206	1	HCV	HCV	NNP
cord-270469-lle32mha	206	2	provides	provide	VBZ
cord-270469-lle32mha	206	3	us	-PRON-	PRP
cord-270469-lle32mha	206	4	with	with	IN
cord-270469-lle32mha	206	5	another	another	DT
cord-270469-lle32mha	206	6	example	example	NN
cord-270469-lle32mha	206	7	of	of	IN
cord-270469-lle32mha	206	8	time	time	NN
cord-270469-lle32mha	206	9	-	-	HYPH
cord-270469-lle32mha	206	10	dependent	dependent	JJ
cord-270469-lle32mha	206	11	regulation	regulation	NN
cord-270469-lle32mha	206	12	of	of	IN
cord-270469-lle32mha	206	13	the	the	DT
cord-270469-lle32mha	206	14	ER	er	NN
cord-270469-lle32mha	206	15	-	-	HYPH
cord-270469-lle32mha	206	16	stress	stress	NN
cord-270469-lle32mha	206	17	response	response	NN
cord-270469-lle32mha	206	18	.	.	.
cord-270469-lle32mha	207	1	This	this	DT
cord-270469-lle32mha	207	2	virus	virus	NN
cord-270469-lle32mha	207	3	triggers	trigger	VBZ
cord-270469-lle32mha	207	4	the	the	DT
cord-270469-lle32mha	207	5	ERstress	erstress	JJ
cord-270469-lle32mha	207	6	response	response	NN
cord-270469-lle32mha	207	7	in	in	IN
cord-270469-lle32mha	207	8	a	a	DT
cord-270469-lle32mha	207	9	wave	wave	NN
cord-270469-lle32mha	207	10	-	-	HYPH
cord-270469-lle32mha	207	11	like	like	JJ
cord-270469-lle32mha	207	12	fashion	fashion	NN
cord-270469-lle32mha	207	13	,	,	,
cord-270469-lle32mha	207	14	which	which	WDT
cord-270469-lle32mha	207	15	peaks	peak	VBZ
cord-270469-lle32mha	207	16	a	a	DT
cord-270469-lle32mha	207	17	few	few	JJ
cord-270469-lle32mha	207	18	days	day	NNS
cord-270469-lle32mha	207	19	after	after	IN
cord-270469-lle32mha	207	20	infection	infection	NN
cord-270469-lle32mha	207	21	.	.	.
cord-270469-lle32mha	208	1	Then	then	RB
cord-270469-lle32mha	208	2	the	the	DT
cord-270469-lle32mha	208	3	hepatocytes	hepatocyte	NNS
cord-270469-lle32mha	208	4	become	become	VBP
cord-270469-lle32mha	208	5	tolerant	tolerant	JJ
cord-270469-lle32mha	208	6	to	to	IN
cord-270469-lle32mha	208	7	the	the	DT
cord-270469-lle32mha	208	8	stress	stress	NN
cord-270469-lle32mha	208	9	induced	induce	VBN
cord-270469-lle32mha	208	10	by	by	IN
cord-270469-lle32mha	208	11	the	the	DT
cord-270469-lle32mha	208	12	virus	virus	NN
cord-270469-lle32mha	208	13	or	or	CC
cord-270469-lle32mha	208	14	by	by	IN
cord-270469-lle32mha	208	15	chemical	chemical	JJ
cord-270469-lle32mha	208	16	agents	agent	NNS
cord-270469-lle32mha	208	17	.	.	.
cord-270469-lle32mha	209	1	Suppression	suppression	NN
cord-270469-lle32mha	209	2	of	of	IN
cord-270469-lle32mha	209	3	viral	viral	JJ
cord-270469-lle32mha	209	4	replication	replication	NN
cord-270469-lle32mha	209	5	restore	restore	VBP
cord-270469-lle32mha	209	6	the	the	DT
cord-270469-lle32mha	209	7	ability	ability	NN
cord-270469-lle32mha	209	8	to	to	TO
cord-270469-lle32mha	209	9	engage	engage	VB
cord-270469-lle32mha	209	10	an	an	DT
cord-270469-lle32mha	209	11	ER	er	NN
cord-270469-lle32mha	209	12	-	-	HYPH
cord-270469-lle32mha	209	13	stress	stress	NN
cord-270469-lle32mha	209	14	response	response	NN
cord-270469-lle32mha	209	15	suggesting	suggest	VBG
cord-270469-lle32mha	209	16	that	that	IN
cord-270469-lle32mha	209	17	,	,	,
cord-270469-lle32mha	209	18	the	the	DT
cord-270469-lle32mha	209	19	virus	virus	NN
cord-270469-lle32mha	209	20	itself	-PRON-	PRP
cord-270469-lle32mha	209	21	is	be	VBZ
cord-270469-lle32mha	209	22	can	can	MD
cord-270469-lle32mha	209	23	regulate	regulate	VB
cord-270469-lle32mha	209	24	the	the	DT
cord-270469-lle32mha	209	25	response	response	NN
cord-270469-lle32mha	209	26	[	[	-LRB-
cord-270469-lle32mha	209	27	61	61	CD
cord-270469-lle32mha	209	28	]	]	-RRB-
cord-270469-lle32mha	209	29	.	.	.
cord-270469-lle32mha	210	1	In	in	IN
cord-270469-lle32mha	210	2	line	line	NN
cord-270469-lle32mha	210	3	with	with	IN
cord-270469-lle32mha	210	4	these	these	DT
cord-270469-lle32mha	210	5	observations	observation	NNS
cord-270469-lle32mha	210	6	,	,	,
cord-270469-lle32mha	210	7	livers	liver	NNS
cord-270469-lle32mha	210	8	from	from	IN
cord-270469-lle32mha	210	9	patients	patient	NNS
cord-270469-lle32mha	210	10	with	with	IN
cord-270469-lle32mha	210	11	untreated	untreated	JJ
cord-270469-lle32mha	210	12	chronic	chronic	JJ
cord-270469-lle32mha	210	13	hepatitis	hepatitis	NN
cord-270469-lle32mha	210	14	C	C	NNP
cord-270469-lle32mha	210	15	exhibit	exhibit	NN
cord-270469-lle32mha	210	16	activation	activation	NN
cord-270469-lle32mha	210	17	of	of	IN
cord-270469-lle32mha	210	18	the	the	DT
cord-270469-lle32mha	210	19	three	three	CD
cord-270469-lle32mha	210	20	ER	er	NN
cord-270469-lle32mha	210	21	-	-	HYPH
cord-270469-lle32mha	210	22	stress	stress	NN
cord-270469-lle32mha	210	23	branches	branch	NNS
cord-270469-lle32mha	210	24	without	without	IN
cord-270469-lle32mha	210	25	apparent	apparent	JJ
cord-270469-lle32mha	210	26	induction	induction	NN
cord-270469-lle32mha	210	27	of	of	IN
cord-270469-lle32mha	210	28	downstream	downstream	JJ
cord-270469-lle32mha	210	29	ER	ER	NNP
cord-270469-lle32mha	210	30	-	-	HYPH
cord-270469-lle32mha	210	31	related	relate	VBN
cord-270469-lle32mha	210	32	responsive	responsive	JJ
cord-270469-lle32mha	210	33	genes	gene	NNS
cord-270469-lle32mha	210	34	[	[	-LRB-
cord-270469-lle32mha	210	35	52	52	CD
cord-270469-lle32mha	210	36	]	]	-RRB-
cord-270469-lle32mha	210	37	.	.	.
cord-270469-lle32mha	211	1	These	these	DT
cord-270469-lle32mha	211	2	findings	finding	NNS
cord-270469-lle32mha	211	3	could	could	MD
cord-270469-lle32mha	211	4	be	be	VB
cord-270469-lle32mha	211	5	explained	explain	VBN
cord-270469-lle32mha	211	6	by	by	IN
cord-270469-lle32mha	211	7	specific	specific	JJ
cord-270469-lle32mha	211	8	dampening	dampening	NN
cord-270469-lle32mha	211	9	of	of	IN
cord-270469-lle32mha	211	10	the	the	DT
cord-270469-lle32mha	211	11	downstream	downstream	JJ
cord-270469-lle32mha	211	12	response	response	NN
cord-270469-lle32mha	211	13	by	by	IN
cord-270469-lle32mha	211	14	viral	viral	JJ
cord-270469-lle32mha	211	15	effectors	effector	NNS
cord-270469-lle32mha	211	16	.	.	.
cord-270469-lle32mha	212	1	It	-PRON-	PRP
cord-270469-lle32mha	212	2	has	have	VBZ
cord-270469-lle32mha	212	3	been	be	VBN
cord-270469-lle32mha	212	4	shown	show	VBN
cord-270469-lle32mha	212	5	that	that	IN
cord-270469-lle32mha	212	6	HCV	HCV	NNP
cord-270469-lle32mha	212	7	reduces	reduce	VBZ
cord-270469-lle32mha	212	8	XBP1	XBP1	NNP
cord-270469-lle32mha	212	9	transcriptional	transcriptional	JJ
cord-270469-lle32mha	212	10	activity	activity	NN
cord-270469-lle32mha	212	11	[	[	-LRB-
cord-270469-lle32mha	212	12	62	62	CD
cord-270469-lle32mha	212	13	]	]	-RRB-
cord-270469-lle32mha	212	14	and	and	CC
cord-270469-lle32mha	212	15	that	that	IN
cord-270469-lle32mha	212	16	the	the	DT
cord-270469-lle32mha	212	17	HCV	HCV	NNP
cord-270469-lle32mha	212	18	envelope	envelope	NN
cord-270469-lle32mha	212	19	protein	protein	NN
cord-270469-lle32mha	212	20	E2	E2	NNP
cord-270469-lle32mha	212	21	may	may	MD
cord-270469-lle32mha	212	22	regulate	regulate	VB
cord-270469-lle32mha	212	23	PERK	perk	NN
cord-270469-lle32mha	212	24	activity	activity	NN
cord-270469-lle32mha	212	25	[	[	-LRB-
cord-270469-lle32mha	212	26	63	63	CD
cord-270469-lle32mha	212	27	]	]	-RRB-
cord-270469-lle32mha	212	28	.	.	.
cord-270469-lle32mha	213	1	Similar	similar	JJ
cord-270469-lle32mha	213	2	observations	observation	NNS
cord-270469-lle32mha	213	3	were	be	VBD
cord-270469-lle32mha	213	4	reported	report	VBN
cord-270469-lle32mha	213	5	for	for	IN
cord-270469-lle32mha	213	6	coronavirus	coronavirus	NN
cord-270469-lle32mha	213	7	mouse	mouse	NN
cord-270469-lle32mha	213	8	hepatitis	hepatitis	NN
cord-270469-lle32mha	213	9	virus	virus	NN
cord-270469-lle32mha	213	10	(	(	-LRB-
cord-270469-lle32mha	213	11	MHV	MHV	NNP
cord-270469-lle32mha	213	12	)	)	-RRB-
cord-270469-lle32mha	213	13	.	.	.
cord-270469-lle32mha	214	1	Infection	infection	NN
cord-270469-lle32mha	214	2	by	by	IN
cord-270469-lle32mha	214	3	MHV	MHV	NNP
cord-270469-lle32mha	214	4	induces	induce	VBZ
cord-270469-lle32mha	214	5	IRE1-mediated	ire1-mediate	VBN
cord-270469-lle32mha	214	6	splicing	splicing	NN
cord-270469-lle32mha	214	7	of	of	IN
cord-270469-lle32mha	214	8	XBP1	XBP1	NNP
cord-270469-lle32mha	215	1	mRNA	mRNA	NNP
cord-270469-lle32mha	215	2	and	and	CC
cord-270469-lle32mha	215	3	the	the	DT
cord-270469-lle32mha	215	4	maturation	maturation	NN
cord-270469-lle32mha	215	5	of	of	IN
cord-270469-lle32mha	215	6	ATF6	ATF6	NNP
cord-270469-lle32mha	215	7	,	,	,
cord-270469-lle32mha	215	8	without	without	IN
cord-270469-lle32mha	215	9	upregulating	upregulate	VBG
cord-270469-lle32mha	215	10	significant	significant	JJ
cord-270469-lle32mha	215	11	downstream	downstream	JJ
cord-270469-lle32mha	215	12	target	target	NN
cord-270469-lle32mha	215	13	genes	gene	NNS
cord-270469-lle32mha	215	14	[	[	-LRB-
cord-270469-lle32mha	215	15	64	64	CD
cord-270469-lle32mha	215	16	]	]	-RRB-
cord-270469-lle32mha	215	17	.	.	.
cord-270469-lle32mha	216	1	Likewise	likewise	RB
cord-270469-lle32mha	216	2	,	,	,
cord-270469-lle32mha	216	3	the	the	DT
cord-270469-lle32mha	216	4	influenza	influenza	NN
cord-270469-lle32mha	216	5	virus	virus	NN
cord-270469-lle32mha	216	6	and	and	CC
cord-270469-lle32mha	216	7	the	the	DT
cord-270469-lle32mha	216	8	Enterovirus	Enterovirus	NNP
cord-270469-lle32mha	216	9	71	71	CD
cord-270469-lle32mha	216	10	(	(	-LRB-
cord-270469-lle32mha	216	11	EV71	EV71	NNP
cord-270469-lle32mha	216	12	)	)	-RRB-
cord-270469-lle32mha	216	13	modulate	modulate	VB
cord-270469-lle32mha	216	14	the	the	DT
cord-270469-lle32mha	216	15	stress	stress	NN
cord-270469-lle32mha	216	16	response	response	NN
cord-270469-lle32mha	216	17	in	in	IN
cord-270469-lle32mha	216	18	the	the	DT
cord-270469-lle32mha	216	19	setting	setting	NN
cord-270469-lle32mha	216	20	of	of	IN
cord-270469-lle32mha	216	21	a	a	DT
cord-270469-lle32mha	216	22	preexisting	preexisting	JJ
cord-270469-lle32mha	216	23	stress	stress	NN
cord-270469-lle32mha	216	24	by	by	IN
cord-270469-lle32mha	216	25	dampening	dampen	VBG
cord-270469-lle32mha	216	26	the	the	DT
cord-270469-lle32mha	216	27	activation	activation	NN
cord-270469-lle32mha	216	28	and	and	CC
cord-270469-lle32mha	216	29	processing	processing	NN
cord-270469-lle32mha	216	30	of	of	IN
cord-270469-lle32mha	216	31	the	the	DT
cord-270469-lle32mha	216	32	ATF6	ATF6	NNP
cord-270469-lle32mha	216	33	as	as	IN
cord-270469-lle32mha	216	34	indicated	indicate	VBN
cord-270469-lle32mha	216	35	by	by	IN
cord-270469-lle32mha	216	36	its	-PRON-	PRP$
cord-270469-lle32mha	216	37	inhibitory	inhibitory	JJ
cord-270469-lle32mha	216	38	effect	effect	NN
cord-270469-lle32mha	216	39	on	on	IN
cord-270469-lle32mha	216	40	ATF6-dependent	ATF6-dependent	NNP
cord-270469-lle32mha	216	41	genes	gene	NNS
cord-270469-lle32mha	216	42	[	[	-LRB-
cord-270469-lle32mha	216	43	56	56	CD
cord-270469-lle32mha	216	44	,	,	,
cord-270469-lle32mha	216	45	65	65	CD
cord-270469-lle32mha	216	46	]	]	-RRB-
cord-270469-lle32mha	216	47	.	.	.
cord-270469-lle32mha	217	1	Parasites	parasite	NNS
cord-270469-lle32mha	217	2	can	can	MD
cord-270469-lle32mha	217	3	also	also	RB
cord-270469-lle32mha	217	4	modulate	modulate	VB
cord-270469-lle32mha	217	5	ER	ER	NNP
cord-270469-lle32mha	217	6	-	-	HYPH
cord-270469-lle32mha	217	7	signaling	signal	VBG
cord-270469-lle32mha	217	8	responses	response	NNS
cord-270469-lle32mha	217	9	.	.	.
cord-270469-lle32mha	218	1	The	the	DT
cord-270469-lle32mha	218	2	host	host	NN
cord-270469-lle32mha	218	3	ATF6	ATF6	NNP
cord-270469-lle32mha	218	4	pathway	pathway	NN
cord-270469-lle32mha	218	5	is	be	VBZ
cord-270469-lle32mha	218	6	targeted	target	VBN
cord-270469-lle32mha	218	7	by	by	IN
cord-270469-lle32mha	218	8	the	the	DT
cord-270469-lle32mha	218	9	T.	t.	NN
cord-270469-lle32mha	218	10	gondii	gondii	NN
cord-270469-lle32mha	218	11	virulence	virulence	NN
cord-270469-lle32mha	218	12	factor	factor	NN
cord-270469-lle32mha	218	13	ROP18	rop18	XX
cord-270469-lle32mha	218	14	[	[	-LRB-
cord-270469-lle32mha	218	15	53	53	CD
cord-270469-lle32mha	218	16	]	]	-RRB-
cord-270469-lle32mha	218	17	.	.	.
cord-270469-lle32mha	219	1	ROP18	ROP18	NNP
cord-270469-lle32mha	219	2	is	be	VBZ
cord-270469-lle32mha	219	3	a	a	DT
cord-270469-lle32mha	219	4	kinase	kinase	NN
cord-270469-lle32mha	219	5	that	that	WDT
cord-270469-lle32mha	219	6	triggers	trigger	VBZ
cord-270469-lle32mha	219	7	proteasome	proteasome	VBN
cord-270469-lle32mha	219	8	-	-	HYPH
cord-270469-lle32mha	219	9	dependent	dependent	JJ
cord-270469-lle32mha	219	10	degradation	degradation	NN
cord-270469-lle32mha	219	11	of	of	IN
cord-270469-lle32mha	219	12	ATF6	ATF6	NNP
cord-270469-lle32mha	219	13	a	a	DT
cord-270469-lle32mha	219	14	process	process	NN
cord-270469-lle32mha	219	15	that	that	WDT
cord-270469-lle32mha	219	16	apparently	apparently	RB
cord-270469-lle32mha	219	17	is	be	VBZ
cord-270469-lle32mha	219	18	required	require	VBN
cord-270469-lle32mha	219	19	for	for	IN
cord-270469-lle32mha	219	20	parasite	parasite	NN
cord-270469-lle32mha	219	21	virulence	virulence	NN
cord-270469-lle32mha	219	22	.	.	.
cord-270469-lle32mha	220	1	These	these	DT
cord-270469-lle32mha	220	2	examples	example	NNS
cord-270469-lle32mha	220	3	demonstrate	demonstrate	VBP
cord-270469-lle32mha	220	4	that	that	IN
cord-270469-lle32mha	220	5	pathogens	pathogen	NNS
cord-270469-lle32mha	220	6	have	have	VBP
cord-270469-lle32mha	220	7	evolved	evolve	VBN
cord-270469-lle32mha	220	8	distinct	distinct	JJ
cord-270469-lle32mha	220	9	mechanisms	mechanism	NNS
cord-270469-lle32mha	220	10	to	to	TO
cord-270469-lle32mha	220	11	regulate	regulate	VB
cord-270469-lle32mha	220	12	and	and	CC
cord-270469-lle32mha	220	13	benefit	benefit	VB
cord-270469-lle32mha	220	14	from	from	IN
cord-270469-lle32mha	220	15	ER	er	NN
cord-270469-lle32mha	220	16	-	-	HYPH
cord-270469-lle32mha	220	17	signaling	signal	VBG
cord-270469-lle32mha	220	18	pathways	pathway	NNS
cord-270469-lle32mha	220	19	.	.	.
cord-270469-lle32mha	221	1	Cells	cell	NNS
cord-270469-lle32mha	221	2	that	that	WDT
cord-270469-lle32mha	221	3	undergo	undergo	VBP
cord-270469-lle32mha	221	4	acute	acute	JJ
cord-270469-lle32mha	221	5	pressure	pressure	NN
cord-270469-lle32mha	221	6	on	on	IN
cord-270469-lle32mha	221	7	the	the	DT
cord-270469-lle32mha	221	8	ER	ER	NNP
cord-270469-lle32mha	221	9	may	may	MD
cord-270469-lle32mha	221	10	trigger	trigger	VB
cord-270469-lle32mha	221	11	an	an	DT
cord-270469-lle32mha	221	12	apoptosis	apoptosis	NN
cord-270469-lle32mha	221	13	program	program	NN
cord-270469-lle32mha	221	14	as	as	IN
cord-270469-lle32mha	221	15	part	part	NN
cord-270469-lle32mha	221	16	of	of	IN
cord-270469-lle32mha	221	17	a	a	DT
cord-270469-lle32mha	221	18	cellular	cellular	JJ
cord-270469-lle32mha	221	19	response	response	NN
cord-270469-lle32mha	221	20	to	to	IN
cord-270469-lle32mha	221	21	acute	acute	JJ
cord-270469-lle32mha	221	22	dysfunction	dysfunction	NN
cord-270469-lle32mha	221	23	.	.	.
cord-270469-lle32mha	222	1	It	-PRON-	PRP
cord-270469-lle32mha	222	2	is	be	VBZ
cord-270469-lle32mha	222	3	therefore	therefore	RB
cord-270469-lle32mha	222	4	likely	likely	JJ
cord-270469-lle32mha	222	5	that	that	IN
cord-270469-lle32mha	222	6	the	the	DT
cord-270469-lle32mha	222	7	dampening	dampening	NN
cord-270469-lle32mha	222	8	of	of	IN
cord-270469-lle32mha	222	9	this	this	DT
cord-270469-lle32mha	222	10	response	response	NN
cord-270469-lle32mha	222	11	by	by	IN
cord-270469-lle32mha	222	12	pathogens	pathogen	NNS
cord-270469-lle32mha	222	13	may	may	MD
cord-270469-lle32mha	222	14	increase	increase	VB
cord-270469-lle32mha	222	15	it	-PRON-	PRP
cord-270469-lle32mha	222	16	life	life	NN
cord-270469-lle32mha	222	17	cycle	cycle	NN
cord-270469-lle32mha	222	18	by	by	IN
cord-270469-lle32mha	222	19	promoting	promote	VBG
cord-270469-lle32mha	222	20	survival	survival	NN
cord-270469-lle32mha	222	21	of	of	IN
cord-270469-lle32mha	222	22	host	host	NN
cord-270469-lle32mha	222	23	cells	cell	NNS
cord-270469-lle32mha	222	24	.	.	.
cord-270469-lle32mha	223	1	Alternatively	alternatively	RB
cord-270469-lle32mha	223	2	,	,	,
cord-270469-lle32mha	223	3	the	the	DT
cord-270469-lle32mha	223	4	pathogen	pathogen	NN
cord-270469-lle32mha	223	5	may	may	MD
cord-270469-lle32mha	223	6	also	also	RB
cord-270469-lle32mha	223	7	manipulate	manipulate	VB
cord-270469-lle32mha	223	8	the	the	DT
cord-270469-lle32mha	223	9	system	system	NN
cord-270469-lle32mha	223	10	to	to	TO
cord-270469-lle32mha	223	11	specifically	specifically	RB
cord-270469-lle32mha	223	12	control	control	VB
cord-270469-lle32mha	223	13	transcriptional	transcriptional	JJ
cord-270469-lle32mha	223	14	programs	program	NNS
cord-270469-lle32mha	223	15	triggered	trigger	VBN
cord-270469-lle32mha	223	16	by	by	IN
cord-270469-lle32mha	223	17	the	the	DT
cord-270469-lle32mha	223	18	ER	er	NN
cord-270469-lle32mha	223	19	-	-	HYPH
cord-270469-lle32mha	223	20	stress	stress	NN
cord-270469-lle32mha	223	21	signaling	signal	VBG
cord-270469-lle32mha	223	22	branches	branch	NNS
cord-270469-lle32mha	223	23	independently	independently	RB
cord-270469-lle32mha	223	24	of	of	IN
cord-270469-lle32mha	223	25	the	the	DT
cord-270469-lle32mha	223	26	ER	er	NN
cord-270469-lle32mha	223	27	-	-	HYPH
cord-270469-lle32mha	223	28	stress	stress	NN
cord-270469-lle32mha	223	29	response	response	NN
cord-270469-lle32mha	223	30	.	.	.
cord-270469-lle32mha	224	1	The	the	DT
cord-270469-lle32mha	224	2	exact	exact	JJ
cord-270469-lle32mha	224	3	function	function	NN
cord-270469-lle32mha	224	4	of	of	IN
cord-270469-lle32mha	224	5	these	these	DT
cord-270469-lle32mha	224	6	programs	program	NNS
cord-270469-lle32mha	224	7	in	in	IN
cord-270469-lle32mha	224	8	the	the	DT
cord-270469-lle32mha	224	9	context	context	NN
cord-270469-lle32mha	224	10	of	of	IN
cord-270469-lle32mha	224	11	an	an	DT
cord-270469-lle32mha	224	12	infection	infection	NN
cord-270469-lle32mha	224	13	in	in	IN
cord-270469-lle32mha	224	14	vivo	vivo	NN
cord-270469-lle32mha	224	15	is	be	VBZ
cord-270469-lle32mha	224	16	unclear	unclear	JJ
cord-270469-lle32mha	224	17	.	.	.
cord-270469-lle32mha	225	1	The	the	DT
cord-270469-lle32mha	225	2	regulation	regulation	NN
cord-270469-lle32mha	225	3	of	of	IN
cord-270469-lle32mha	225	4	inflammatory	inflammatory	JJ
cord-270469-lle32mha	225	5	and	and	CC
cord-270469-lle32mha	225	6	immune	immune	JJ
cord-270469-lle32mha	225	7	functions	function	NNS
cord-270469-lle32mha	225	8	as	as	RB
cord-270469-lle32mha	225	9	well	well	RB
cord-270469-lle32mha	225	10	as	as	IN
cord-270469-lle32mha	225	11	the	the	DT
cord-270469-lle32mha	225	12	induction	induction	NN
cord-270469-lle32mha	225	13	of	of	IN
cord-270469-lle32mha	225	14	pathogen	pathogen	NN
cord-270469-lle32mha	225	15	specific	specific	JJ
cord-270469-lle32mha	225	16	transcriptional	transcriptional	JJ
cord-270469-lle32mha	225	17	programs	program	NNS
cord-270469-lle32mha	225	18	may	may	MD
cord-270469-lle32mha	225	19	represent	represent	VB
cord-270469-lle32mha	225	20	key	key	JJ
cord-270469-lle32mha	225	21	mechanisms	mechanism	NNS
cord-270469-lle32mha	225	22	orchestrated	orchestrate	VBN
cord-270469-lle32mha	225	23	by	by	IN
cord-270469-lle32mha	225	24	pathogens	pathogen	NNS
cord-270469-lle32mha	225	25	takeover	takeover	NN
cord-270469-lle32mha	225	26	of	of	IN
cord-270469-lle32mha	225	27	ER	er	NN
cord-270469-lle32mha	225	28	-	-	HYPH
cord-270469-lle32mha	225	29	signaling	signal	VBG
cord-270469-lle32mha	225	30	pathways	pathway	NNS
cord-270469-lle32mha	225	31	.	.	.
cord-270469-lle32mha	226	1	The	the	DT
cord-270469-lle32mha	226	2	overall	overall	JJ
cord-270469-lle32mha	226	3	message	message	NN
cord-270469-lle32mha	226	4	of	of	IN
cord-270469-lle32mha	226	5	this	this	DT
cord-270469-lle32mha	226	6	review	review	NN
cord-270469-lle32mha	226	7	is	be	VBZ
cord-270469-lle32mha	226	8	that	that	IN
cord-270469-lle32mha	226	9	ER	er	NN
cord-270469-lle32mha	226	10	-	-	HYPH
cord-270469-lle32mha	226	11	signaling	signal	VBG
cord-270469-lle32mha	226	12	pathways	pathway	NNS
cord-270469-lle32mha	226	13	steaming	steam	VBG
cord-270469-lle32mha	226	14	from	from	IN
cord-270469-lle32mha	226	15	the	the	DT
cord-270469-lle32mha	226	16	ER	ER	NNP
cord-270469-lle32mha	226	17	are	be	VBP
cord-270469-lle32mha	226	18	often	often	RB
cord-270469-lle32mha	226	19	tightly	tightly	RB
cord-270469-lle32mha	226	20	linked	link	VBN
cord-270469-lle32mha	226	21	to	to	IN
cord-270469-lle32mha	226	22	inflammation	inflammation	NN
cord-270469-lle32mha	226	23	and	and	CC
cord-270469-lle32mha	226	24	immunity	immunity	NN
cord-270469-lle32mha	226	25	.	.	.
cord-270469-lle32mha	227	1	The	the	DT
cord-270469-lle32mha	227	2	ER	ER	NNP
cord-270469-lle32mha	227	3	is	be	VBZ
cord-270469-lle32mha	227	4	therefore	therefore	RB
cord-270469-lle32mha	227	5	a	a	DT
cord-270469-lle32mha	227	6	central	central	JJ
cord-270469-lle32mha	227	7	stress	stress	NN
cord-270469-lle32mha	227	8	sensor	sensor	NN
cord-270469-lle32mha	227	9	that	that	WDT
cord-270469-lle32mha	227	10	detects	detect	VBZ
cord-270469-lle32mha	227	11	cellular	cellular	JJ
cord-270469-lle32mha	227	12	insults	insult	NNS
cord-270469-lle32mha	227	13	and	and	CC
cord-270469-lle32mha	227	14	trigger	trigger	VB
cord-270469-lle32mha	227	15	specific	specific	JJ
cord-270469-lle32mha	227	16	responses	response	NNS
cord-270469-lle32mha	227	17	involved	involve	VBN
cord-270469-lle32mha	227	18	in	in	IN
cord-270469-lle32mha	227	19	restoring	restore	VBG
cord-270469-lle32mha	227	20	homeostasis	homeostasis	NN
cord-270469-lle32mha	227	21	as	as	RB
cord-270469-lle32mha	227	22	well	well	RB
cord-270469-lle32mha	227	23	as	as	IN
cord-270469-lle32mha	227	24	promoting	promote	VBG
cord-270469-lle32mha	227	25	immunity	immunity	NN
cord-270469-lle32mha	227	26	.	.	.
cord-270469-lle32mha	228	1	However	however	RB
cord-270469-lle32mha	228	2	,	,	,
cord-270469-lle32mha	228	3	there	there	EX
cord-270469-lle32mha	228	4	are	be	VBP
cord-270469-lle32mha	228	5	many	many	JJ
cord-270469-lle32mha	228	6	knowledge	knowledge	NN
cord-270469-lle32mha	228	7	gaps	gap	NNS
cord-270469-lle32mha	228	8	that	that	WDT
cord-270469-lle32mha	228	9	need	need	VBP
cord-270469-lle32mha	228	10	to	to	TO
cord-270469-lle32mha	228	11	be	be	VB
cord-270469-lle32mha	228	12	investigated	investigate	VBN
cord-270469-lle32mha	228	13	in	in	IN
cord-270469-lle32mha	228	14	order	order	NN
cord-270469-lle32mha	228	15	to	to	TO
cord-270469-lle32mha	228	16	have	have	VB
cord-270469-lle32mha	228	17	a	a	DT
cord-270469-lle32mha	228	18	comprehensive	comprehensive	JJ
cord-270469-lle32mha	228	19	picture	picture	NN
cord-270469-lle32mha	228	20	of	of	IN
cord-270469-lle32mha	228	21	how	how	WRB
cord-270469-lle32mha	228	22	innate	innate	JJ
cord-270469-lle32mha	228	23	immune	immune	JJ
cord-270469-lle32mha	228	24	signaling	signal	VBG
cord-270469-lle32mha	228	25	pathways	pathway	NNS
cord-270469-lle32mha	228	26	intersect	intersect	VBP
cord-270469-lle32mha	228	27	with	with	IN
cord-270469-lle32mha	228	28	signaling	signal	VBG
cord-270469-lle32mha	228	29	branches	branch	NNS
cord-270469-lle32mha	228	30	emerging	emerge	VBG
cord-270469-lle32mha	228	31	from	from	IN
cord-270469-lle32mha	228	32	the	the	DT
cord-270469-lle32mha	228	33	ER	ER	NNP
cord-270469-lle32mha	228	34	.	.	.
cord-270469-lle32mha	229	1	The	the	DT
cord-270469-lle32mha	229	2	challenge	challenge	NN
cord-270469-lle32mha	229	3	for	for	IN
cord-270469-lle32mha	229	4	the	the	DT
cord-270469-lle32mha	229	5	future	future	NN
cord-270469-lle32mha	229	6	is	be	VBZ
cord-270469-lle32mha	229	7	to	to	TO
cord-270469-lle32mha	229	8	characterize	characterize	VB
cord-270469-lle32mha	229	9	at	at	IN
cord-270469-lle32mha	229	10	the	the	DT
cord-270469-lle32mha	229	11	molecular	molecular	JJ
cord-270469-lle32mha	229	12	level	level	NN
cord-270469-lle32mha	229	13	the	the	DT
cord-270469-lle32mha	229	14	proximal	proximal	JJ
cord-270469-lle32mha	229	15	pathways	pathway	NNS
cord-270469-lle32mha	229	16	that	that	WDT
cord-270469-lle32mha	229	17	emerge	emerge	VBP
cord-270469-lle32mha	229	18	from	from	IN
cord-270469-lle32mha	229	19	the	the	DT
cord-270469-lle32mha	229	20	ER	er	NN
cord-270469-lle32mha	229	21	-	-	HYPH
cord-270469-lle32mha	229	22	stress	stress	NN
cord-270469-lle32mha	229	23	signaling	signal	VBG
cord-270469-lle32mha	229	24	pathways	pathway	NNS
cord-270469-lle32mha	229	25	and	and	CC
cord-270469-lle32mha	229	26	to	to	TO
cord-270469-lle32mha	229	27	understand	understand	VB
cord-270469-lle32mha	229	28	how	how	WRB
cord-270469-lle32mha	229	29	these	these	DT
cord-270469-lle32mha	229	30	branches	branch	NNS
cord-270469-lle32mha	229	31	are	be	VBP
cord-270469-lle32mha	229	32	activated	activate	VBN
cord-270469-lle32mha	229	33	and	and	CC
cord-270469-lle32mha	229	34	regulated	regulate	VBN
cord-270469-lle32mha	229	35	by	by	IN
cord-270469-lle32mha	229	36	pathogens	pathogen	NNS
cord-270469-lle32mha	229	37	,	,	,
cord-270469-lle32mha	229	38	pathogen	pathogen	NN
cord-270469-lle32mha	229	39	virulence	virulence	NN
cord-270469-lle32mha	229	40	factors	factor	NNS
cord-270469-lle32mha	229	41	as	as	RB
cord-270469-lle32mha	229	42	well	well	RB
cord-270469-lle32mha	229	43	as	as	IN
cord-270469-lle32mha	229	44	innate	innate	JJ
cord-270469-lle32mha	229	45	immune	immune	JJ
cord-270469-lle32mha	229	46	signaling	signal	VBG
cord-270469-lle32mha	229	47	component	component	NN
cord-270469-lle32mha	229	48	such	such	JJ
cord-270469-lle32mha	229	49	as	as	IN
cord-270469-lle32mha	229	50	TLRs	TLRs	NNP
cord-270469-lle32mha	229	51	.	.	.
cord-270469-lle32mha	230	1	ER	er	NN
cord-270469-lle32mha	230	2	-	-	HYPH
cord-270469-lle32mha	230	3	stress	stress	NN
cord-270469-lle32mha	230	4	is	be	VBZ
cord-270469-lle32mha	230	5	often	often	RB
cord-270469-lle32mha	230	6	defined	define	VBN
cord-270469-lle32mha	230	7	by	by	IN
cord-270469-lle32mha	230	8	the	the	DT
cord-270469-lle32mha	230	9	induction	induction	NN
cord-270469-lle32mha	230	10	of	of	IN
cord-270469-lle32mha	230	11	the	the	DT
cord-270469-lle32mha	230	12	ERstress	ERstress	NNP
cord-270469-lle32mha	230	13	response	response	NN
cord-270469-lle32mha	230	14	,	,	,
cord-270469-lle32mha	230	15	however	however	RB
cord-270469-lle32mha	230	16	it	-PRON-	PRP
cord-270469-lle32mha	230	17	is	be	VBZ
cord-270469-lle32mha	230	18	now	now	RB
cord-270469-lle32mha	230	19	clear	clear	JJ
cord-270469-lle32mha	230	20	that	that	DT
cord-270469-lle32mha	230	21	pathogen	pathogen	NN
cord-270469-lle32mha	230	22	as	as	RB
cord-270469-lle32mha	230	23	well	well	RB
cord-270469-lle32mha	230	24	as	as	IN
cord-270469-lle32mha	230	25	inflammatory	inflammatory	JJ
cord-270469-lle32mha	230	26	condition	condition	NN
cord-270469-lle32mha	230	27	can	can	MD
cord-270469-lle32mha	230	28	operate	operate	VB
cord-270469-lle32mha	230	29	ER	ER	NNP
cord-270469-lle32mha	230	30	-	-	HYPH
cord-270469-lle32mha	230	31	signaling	signal	VBG
cord-270469-lle32mha	230	32	pathways	pathway	NNS
cord-270469-lle32mha	230	33	in	in	IN
cord-270469-lle32mha	230	34	absence	absence	NN
cord-270469-lle32mha	230	35	of	of	IN
cord-270469-lle32mha	230	36	ER	er	NN
cord-270469-lle32mha	230	37	-	-	HYPH
cord-270469-lle32mha	230	38	stress	stress	NN
cord-270469-lle32mha	230	39	.	.	.
cord-270469-lle32mha	231	1	The	the	DT
cord-270469-lle32mha	231	2	development	development	NN
cord-270469-lle32mha	231	3	of	of	IN
cord-270469-lle32mha	231	4	new	new	JJ
cord-270469-lle32mha	231	5	techniques	technique	NNS
cord-270469-lle32mha	231	6	and	and	CC
cord-270469-lle32mha	231	7	reagents	reagent	NNS
cord-270469-lle32mha	231	8	to	to	TO
cord-270469-lle32mha	231	9	monitor	monitor	VB
cord-270469-lle32mha	231	10	the	the	DT
cord-270469-lle32mha	231	11	stress	stress	NN
cord-270469-lle32mha	231	12	in	in	IN
cord-270469-lle32mha	231	13	the	the	DT
cord-270469-lle32mha	231	14	ER	ER	NNP
cord-270469-lle32mha	231	15	as	as	RB
cord-270469-lle32mha	231	16	well	well	RB
cord-270469-lle32mha	231	17	as	as	IN
cord-270469-lle32mha	231	18	the	the	DT
cord-270469-lle32mha	231	19	activation	activation	NN
cord-270469-lle32mha	231	20	of	of	IN
cord-270469-lle32mha	231	21	ER	er	NN
cord-270469-lle32mha	231	22	-	-	HYPH
cord-270469-lle32mha	231	23	signaling	signal	VBG
cord-270469-lle32mha	231	24	branches	branch	NNS
cord-270469-lle32mha	231	25	will	will	MD
cord-270469-lle32mha	231	26	foster	foster	VB
cord-270469-lle32mha	231	27	a	a	DT
cord-270469-lle32mha	231	28	better	well	JJR
cord-270469-lle32mha	231	29	characterization	characterization	NN
cord-270469-lle32mha	231	30	of	of	IN
cord-270469-lle32mha	231	31	these	these	DT
cord-270469-lle32mha	231	32	pathways	pathway	NNS
cord-270469-lle32mha	231	33	in	in	IN
cord-270469-lle32mha	231	34	immunity	immunity	NN
cord-270469-lle32mha	231	35	.	.	.
cord-270469-lle32mha	232	1	Deficiencies	deficiency	NNS
cord-270469-lle32mha	232	2	in	in	IN
cord-270469-lle32mha	232	3	the	the	DT
cord-270469-lle32mha	232	4	main	main	JJ
cord-270469-lle32mha	232	5	components	component	NNS
cord-270469-lle32mha	232	6	of	of	IN
cord-270469-lle32mha	232	7	the	the	DT
cord-270469-lle32mha	232	8	ER	er	NN
cord-270469-lle32mha	232	9	-	-	HYPH
cord-270469-lle32mha	232	10	signaling	signal	VBG
cord-270469-lle32mha	232	11	pathways	pathway	NNS
cord-270469-lle32mha	232	12	are	be	VBP
cord-270469-lle32mha	232	13	generally	generally	RB
cord-270469-lle32mha	232	14	lethal	lethal	JJ
cord-270469-lle32mha	232	15	in	in	IN
cord-270469-lle32mha	232	16	mice	mouse	NNS
cord-270469-lle32mha	232	17	.	.	.
cord-270469-lle32mha	233	1	The	the	DT
cord-270469-lle32mha	233	2	development	development	NN
cord-270469-lle32mha	233	3	of	of	IN
cord-270469-lle32mha	233	4	new	new	JJ
cord-270469-lle32mha	233	5	mouse	mouse	NN
cord-270469-lle32mha	233	6	models	model	NNS
cord-270469-lle32mha	233	7	with	with	IN
cord-270469-lle32mha	233	8	conditional	conditional	JJ
cord-270469-lle32mha	233	9	deletion	deletion	NN
cord-270469-lle32mha	233	10	of	of	IN
cord-270469-lle32mha	233	11	specific	specific	JJ
cord-270469-lle32mha	233	12	ER	er	NN
cord-270469-lle32mha	233	13	-	-	HYPH
cord-270469-lle32mha	233	14	signaling	signal	VBG
cord-270469-lle32mha	233	15	pathways	pathway	NNS
cord-270469-lle32mha	233	16	may	may	MD
cord-270469-lle32mha	233	17	therefore	therefore	RB
cord-270469-lle32mha	233	18	help	help	VB
cord-270469-lle32mha	233	19	assess	assess	VB
cord-270469-lle32mha	233	20	the	the	DT
cord-270469-lle32mha	233	21	physiological	physiological	JJ
cord-270469-lle32mha	233	22	importance	importance	NN
cord-270469-lle32mha	233	23	of	of	IN
cord-270469-lle32mha	233	24	these	these	DT
cord-270469-lle32mha	233	25	responses	response	NNS
cord-270469-lle32mha	233	26	during	during	IN
cord-270469-lle32mha	233	27	the	the	DT
cord-270469-lle32mha	233	28	course	course	NN
cord-270469-lle32mha	233	29	of	of	IN
cord-270469-lle32mha	233	30	infections	infection	NNS
cord-270469-lle32mha	233	31	as	as	RB
cord-270469-lle32mha	233	32	well	well	RB
cord-270469-lle32mha	233	33	as	as	IN
cord-270469-lle32mha	233	34	in	in	IN
cord-270469-lle32mha	233	35	autoimmune	autoimmune	JJ
cord-270469-lle32mha	233	36	and	and	CC
cord-270469-lle32mha	233	37	autoinflammatory	autoinflammatory	JJ
cord-270469-lle32mha	233	38	diseases	disease	NNS
cord-270469-lle32mha	233	39	.	.	.
cord-270469-lle32mha	234	1	It	-PRON-	PRP
cord-270469-lle32mha	234	2	will	will	MD
cord-270469-lle32mha	234	3	be	be	VB
cord-270469-lle32mha	234	4	also	also	RB
cord-270469-lle32mha	234	5	important	important	JJ
cord-270469-lle32mha	234	6	to	to	TO
cord-270469-lle32mha	234	7	understand	understand	VB
cord-270469-lle32mha	234	8	how	how	WRB
cord-270469-lle32mha	234	9	ER	er	NN
cord-270469-lle32mha	234	10	-	-	HYPH
cord-270469-lle32mha	234	11	signaling	signal	VBG
cord-270469-lle32mha	234	12	pathways	pathway	NNS
cord-270469-lle32mha	234	13	affect	affect	VBP
cord-270469-lle32mha	234	14	immune	immune	JJ
cord-270469-lle32mha	234	15	responses	response	NNS
cord-270469-lle32mha	234	16	in	in	IN
cord-270469-lle32mha	234	17	cooperation	cooperation	NN
cord-270469-lle32mha	234	18	with	with	IN
cord-270469-lle32mha	234	19	other	other	JJ
cord-270469-lle32mha	234	20	stress	stress	NN
cord-270469-lle32mha	234	21	responses	response	NNS
cord-270469-lle32mha	234	22	related	relate	VBN
cord-270469-lle32mha	234	23	to	to	IN
cord-270469-lle32mha	234	24	the	the	DT
cord-270469-lle32mha	234	25	proteostasis	proteostasis	NNP
cord-270469-lle32mha	234	26	network	network	NN
cord-270469-lle32mha	234	27	such	such	JJ
cord-270469-lle32mha	234	28	as	as	IN
cord-270469-lle32mha	234	29	autophagy	autophagy	NN
cord-270469-lle32mha	234	30	and	and	CC
cord-270469-lle32mha	234	31	the	the	DT
cord-270469-lle32mha	234	32	oxidative	oxidative	JJ
cord-270469-lle32mha	234	33	stress	stress	NN
cord-270469-lle32mha	234	34	response	response	NN
cord-270469-lle32mha	234	35	.	.	.
cord-270469-lle32mha	235	1	Finally	finally	RB
cord-270469-lle32mha	235	2	,	,	,
cord-270469-lle32mha	235	3	it	-PRON-	PRP
cord-270469-lle32mha	235	4	is	be	VBZ
cord-270469-lle32mha	235	5	tempting	tempt	VBG
cord-270469-lle32mha	235	6	to	to	TO
cord-270469-lle32mha	235	7	speculate	speculate	VB
cord-270469-lle32mha	235	8	that	that	IN
cord-270469-lle32mha	235	9	the	the	DT
cord-270469-lle32mha	235	10	development	development	NN
cord-270469-lle32mha	235	11	of	of	IN
cord-270469-lle32mha	235	12	drugs	drug	NNS
cord-270469-lle32mha	235	13	to	to	TO
cord-270469-lle32mha	235	14	alleviate	alleviate	VB
cord-270469-lle32mha	235	15	ERstress	erstress	JJ
cord-270469-lle32mha	235	16	or	or	CC
cord-270469-lle32mha	235	17	regulate	regulate	VB
cord-270469-lle32mha	235	18	specific	specific	JJ
cord-270469-lle32mha	235	19	branches	branch	NNS
cord-270469-lle32mha	235	20	of	of	IN
cord-270469-lle32mha	235	21	the	the	DT
cord-270469-lle32mha	235	22	ER	er	NN
cord-270469-lle32mha	235	23	-	-	HYPH
cord-270469-lle32mha	235	24	stress	stress	NN
cord-270469-lle32mha	235	25	response	response	NN
cord-270469-lle32mha	235	26	may	may	MD
cord-270469-lle32mha	235	27	provide	provide	VB
cord-270469-lle32mha	235	28	new	new	JJ
cord-270469-lle32mha	235	29	therapeutic	therapeutic	JJ
cord-270469-lle32mha	235	30	approaches	approach	NNS
cord-270469-lle32mha	235	31	in	in	IN
cord-270469-lle32mha	235	32	the	the	DT
cord-270469-lle32mha	235	33	regulation	regulation	NN
cord-270469-lle32mha	235	34	of	of	IN
cord-270469-lle32mha	235	35	infectious	infectious	JJ
cord-270469-lle32mha	235	36	and	and	CC
cord-270469-lle32mha	235	37	immune	immune	JJ
cord-270469-lle32mha	235	38	-	-	HYPH
cord-270469-lle32mha	235	39	related	relate	VBN
cord-270469-lle32mha	235	40	diseases	disease	NNS
cord-270469-lle32mha	235	41	.	.	.
cord-270469-lle32mha	236	1	Regulation	regulation	NN
cord-270469-lle32mha	236	2	of	of	IN
cord-270469-lle32mha	236	3	innate	innate	JJ
cord-270469-lle32mha	236	4	immunity	immunity	NN
cord-270469-lle32mha	236	5	by	by	IN
cord-270469-lle32mha	236	6	signaling	signal	VBG
cord-270469-lle32mha	236	7	pathways	pathway	NNS
cord-270469-lle32mha	236	8	emerging	emerge	VBG
cord-270469-lle32mha	236	9	from	from	IN
cord-270469-lle32mha	236	10	the	the	DT
cord-270469-lle32mha	236	11	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	236	12	reticulum	reticulum	NN
cord-270469-lle32mha	237	1	The	the	DT
cord-270469-lle32mha	237	2	danger	danger	NN
cord-270469-lle32mha	237	3	model	model	NN
cord-270469-lle32mha	237	4	:	:	:
cord-270469-lle32mha	238	1	a	a	DT
cord-270469-lle32mha	238	2	renewed	renew	VBN
cord-270469-lle32mha	238	3	sense	sense	NN
cord-270469-lle32mha	238	4	of	of	IN
cord-270469-lle32mha	238	5	self	self	NN
cord-270469-lle32mha	238	6	Endoplasmic	Endoplasmic	NNP
cord-270469-lle32mha	238	7	reticulum	reticulum	NN
cord-270469-lle32mha	238	8	stress	stress	NN
cord-270469-lle32mha	238	9	and	and	CC
cord-270469-lle32mha	238	10	the	the	DT
cord-270469-lle32mha	238	11	inflammatory	inflammatory	JJ
cord-270469-lle32mha	238	12	basis	basis	NN
cord-270469-lle32mha	238	13	of	of	IN
cord-270469-lle32mha	238	14	metabolic	metabolic	JJ
cord-270469-lle32mha	238	15	disease	disease	NN
cord-270469-lle32mha	238	16	Aberrant	aberrant	JJ
cord-270469-lle32mha	238	17	mucin	mucin	NN
cord-270469-lle32mha	238	18	assembly	assembly	NN
cord-270469-lle32mha	238	19	in	in	IN
cord-270469-lle32mha	238	20	mice	mouse	NNS
cord-270469-lle32mha	238	21	causes	cause	VBZ
cord-270469-lle32mha	238	22	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	238	23	reticulum	reticulum	NN
cord-270469-lle32mha	238	24	stress	stress	NN
cord-270469-lle32mha	238	25	and	and	CC
cord-270469-lle32mha	238	26	spontaneous	spontaneous	JJ
cord-270469-lle32mha	238	27	inflammation	inflammation	NN
cord-270469-lle32mha	238	28	resembling	resemble	VBG
cord-270469-lle32mha	238	29	ulcerative	ulcerative	JJ
cord-270469-lle32mha	238	30	colitis	colitis	NN
cord-270469-lle32mha	238	31	Detection	detection	NN
cord-270469-lle32mha	238	32	of	of	IN
cord-270469-lle32mha	238	33	immune	immune	JJ
cord-270469-lle32mha	238	34	danger	danger	NN
cord-270469-lle32mha	238	35	signals	signal	NNS
cord-270469-lle32mha	238	36	by	by	IN
cord-270469-lle32mha	238	37	NALP3	NALP3	NNP
cord-270469-lle32mha	238	38	Emerging	emerge	VBG
cord-270469-lle32mha	238	39	evidence	evidence	NN
cord-270469-lle32mha	238	40	for	for	IN
cord-270469-lle32mha	238	41	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	238	42	reticulum	reticulum	NN
cord-270469-lle32mha	238	43	stress	stress	NN
cord-270469-lle32mha	238	44	in	in	IN
cord-270469-lle32mha	238	45	the	the	DT
cord-270469-lle32mha	238	46	pathogenesis	pathogenesis	NN
cord-270469-lle32mha	238	47	of	of	IN
cord-270469-lle32mha	238	48	idiopathic	idiopathic	JJ
cord-270469-lle32mha	238	49	pulmonary	pulmonary	JJ
cord-270469-lle32mha	238	50	fibrosis	fibrosis	NN
cord-270469-lle32mha	238	51	Origin	Origin	NNP
cord-270469-lle32mha	238	52	and	and	CC
cord-270469-lle32mha	238	53	physiological	physiological	JJ
cord-270469-lle32mha	238	54	roles	role	NNS
cord-270469-lle32mha	238	55	of	of	IN
cord-270469-lle32mha	238	56	inflammation	inflammation	NN
cord-270469-lle32mha	238	57	Pathogeneendoplasmic	Pathogeneendoplasmic	NNP
cord-270469-lle32mha	238	58	-	-	HYPH
cord-270469-lle32mha	238	59	reticulum	reticulum	NN
cord-270469-lle32mha	238	60	interactions	interaction	NNS
cord-270469-lle32mha	238	61	:	:	:
cord-270469-lle32mha	238	62	in	in	IN
cord-270469-lle32mha	238	63	through	through	IN
cord-270469-lle32mha	238	64	the	the	DT
cord-270469-lle32mha	238	65	out	out	JJ
cord-270469-lle32mha	238	66	door	door	NN
cord-270469-lle32mha	238	67	Mitochondrial	mitochondrial	JJ
cord-270469-lle32mha	238	68	reactive	reactive	JJ
cord-270469-lle32mha	238	69	oxygen	oxygen	NN
cord-270469-lle32mha	238	70	species	specie	NNS
cord-270469-lle32mha	238	71	promote	promote	VBP
cord-270469-lle32mha	238	72	production	production	NN
cord-270469-lle32mha	238	73	of	of	IN
cord-270469-lle32mha	238	74	proinflammatory	proinflammatory	JJ
cord-270469-lle32mha	238	75	cytokines	cytokine	NNS
cord-270469-lle32mha	238	76	and	and	CC
cord-270469-lle32mha	238	77	are	be	VBP
cord-270469-lle32mha	238	78	elevated	elevate	VBN
cord-270469-lle32mha	238	79	in	in	IN
cord-270469-lle32mha	238	80	TNFR1-associated	tnfr1-associated	JJ
cord-270469-lle32mha	238	81	periodic	periodic	JJ
cord-270469-lle32mha	238	82	syndrome	syndrome	NN
cord-270469-lle32mha	238	83	(	(	-LRB-
cord-270469-lle32mha	238	84	TRAPS	trap	NNS
cord-270469-lle32mha	238	85	)	)	-RRB-
cord-270469-lle32mha	239	1	The	the	DT
cord-270469-lle32mha	239	2	mammalian	mammalian	JJ
cord-270469-lle32mha	239	3	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	239	4	reticulum	reticulum	NN
cord-270469-lle32mha	239	5	as	as	IN
cord-270469-lle32mha	239	6	a	a	DT
cord-270469-lle32mha	239	7	sensor	sensor	NN
cord-270469-lle32mha	239	8	for	for	IN
cord-270469-lle32mha	239	9	cellular	cellular	JJ
cord-270469-lle32mha	239	10	stress	stress	NN
cord-270469-lle32mha	239	11	Autoinflammatory	Autoinflammatory	NNP
cord-270469-lle32mha	239	12	disease	disease	NN
cord-270469-lle32mha	239	13	reloaded	reload	VBD
cord-270469-lle32mha	239	14	:	:	:
cord-270469-lle32mha	239	15	a	a	DT
cord-270469-lle32mha	239	16	clinical	clinical	JJ
cord-270469-lle32mha	239	17	perspective	perspective	NN
cord-270469-lle32mha	240	1	The	the	DT
cord-270469-lle32mha	240	2	unfolded	unfolded	JJ
cord-270469-lle32mha	240	3	protein	protein	NN
cord-270469-lle32mha	240	4	response	response	NN
cord-270469-lle32mha	240	5	:	:	:
cord-270469-lle32mha	240	6	from	from	IN
cord-270469-lle32mha	240	7	stress	stress	NN
cord-270469-lle32mha	240	8	pathway	pathway	NN
cord-270469-lle32mha	240	9	to	to	IN
cord-270469-lle32mha	240	10	homeostatic	homeostatic	JJ
cord-270469-lle32mha	240	11	regulation	regulation	NN
cord-270469-lle32mha	241	1	ER	ER	NNP
cord-270469-lle32mha	241	2	stress	stress	NN
cord-270469-lle32mha	241	3	activates	activate	VBZ
cord-270469-lle32mha	241	4	the	the	DT
cord-270469-lle32mha	241	5	NLRP3	nlrp3	XX
cord-270469-lle32mha	241	6	inflammasome	inflammasome	NNP
cord-270469-lle32mha	241	7	via	via	IN
cord-270469-lle32mha	241	8	an	an	DT
cord-270469-lle32mha	241	9	UPR	UPR	NNP
cord-270469-lle32mha	241	10	-	-	HYPH
cord-270469-lle32mha	241	11	independent	independent	JJ
cord-270469-lle32mha	241	12	pathway	pathway	NN
cord-270469-lle32mha	241	13	Biological	Biological	NNP
cord-270469-lle32mha	241	14	and	and	CC
cord-270469-lle32mha	241	15	chemical	chemical	NN
cord-270469-lle32mha	241	16	approaches	approach	NNS
cord-270469-lle32mha	241	17	to	to	IN
cord-270469-lle32mha	241	18	diseases	disease	NNS
cord-270469-lle32mha	241	19	of	of	IN
cord-270469-lle32mha	241	20	proteostasis	proteostasis	NNP
cord-270469-lle32mha	241	21	deficiency	deficiency	NN
cord-270469-lle32mha	242	1	TLR	TLR	NNP
cord-270469-lle32mha	242	2	activation	activation	NN
cord-270469-lle32mha	242	3	of	of	IN
cord-270469-lle32mha	242	4	the	the	DT
cord-270469-lle32mha	242	5	transcription	transcription	NN
cord-270469-lle32mha	242	6	factor	factor	NN
cord-270469-lle32mha	242	7	XBP1	XBP1	NNP
cord-270469-lle32mha	242	8	regulates	regulate	VBZ
cord-270469-lle32mha	242	9	innate	innate	JJ
cord-270469-lle32mha	242	10	immune	immune	JJ
cord-270469-lle32mha	242	11	responses	response	NNS
cord-270469-lle32mha	242	12	in	in	IN
cord-270469-lle32mha	242	13	macrophages	macrophage	NNS
cord-270469-lle32mha	242	14	Stress	Stress	NNP
cord-270469-lle32mha	242	15	management	management	NN
cord-270469-lle32mha	242	16	at	at	IN
cord-270469-lle32mha	242	17	the	the	DT
cord-270469-lle32mha	242	18	ER	er	NN
cord-270469-lle32mha	242	19	:	:	:
cord-270469-lle32mha	243	1	regulators	regulator	NNS
cord-270469-lle32mha	243	2	of	of	IN
cord-270469-lle32mha	243	3	ER	ER	NNP
cord-270469-lle32mha	243	4	stress	stress	NN
cord-270469-lle32mha	243	5	-	-	HYPH
cord-270469-lle32mha	243	6	induced	induce	VBN
cord-270469-lle32mha	243	7	apoptosis	apoptosis	NN
cord-270469-lle32mha	243	8	ER	ER	NNP
cord-270469-lle32mha	243	9	stress	stress	NN
cord-270469-lle32mha	243	10	and	and	CC
cord-270469-lle32mha	243	11	its	-PRON-	PRP$
cord-270469-lle32mha	243	12	regulator	regulator	NN
cord-270469-lle32mha	243	13	X	x	NN
cord-270469-lle32mha	243	14	-	-	HYPH
cord-270469-lle32mha	243	15	box	box	NN
cord-270469-lle32mha	243	16	-	-	HYPH
cord-270469-lle32mha	243	17	binding	bind	VBG
cord-270469-lle32mha	243	18	protein-1	protein-1	NNP
cord-270469-lle32mha	243	19	enhance	enhance	VB
cord-270469-lle32mha	243	20	polyIC	polyIC	NNP
cord-270469-lle32mha	243	21	-	-	HYPH
cord-270469-lle32mha	243	22	induced	induce	VBN
cord-270469-lle32mha	243	23	innate	innate	JJ
cord-270469-lle32mha	243	24	immune	immune	JJ
cord-270469-lle32mha	243	25	response	response	NN
cord-270469-lle32mha	243	26	in	in	IN
cord-270469-lle32mha	243	27	dendritic	dendritic	JJ
cord-270469-lle32mha	243	28	cells	cell	NNS
cord-270469-lle32mha	243	29	,	,	,
cord-270469-lle32mha	243	30	þ3	þ3	NNP
cord-270469-lle32mha	243	31	Endoplasmic	Endoplasmic	NNP
cord-270469-lle32mha	243	32	reticulum	reticulum	NN
cord-270469-lle32mha	243	33	stress	stress	NN
cord-270469-lle32mha	243	34	in	in	IN
cord-270469-lle32mha	243	35	disease	disease	NN
cord-270469-lle32mha	243	36	pathogenesis	pathogenesis	NN
cord-270469-lle32mha	243	37	Endoplasmic	Endoplasmic	NNP
cord-270469-lle32mha	243	38	reticulum	reticulum	NN
cord-270469-lle32mha	243	39	stress	stress	NN
cord-270469-lle32mha	243	40	and	and	CC
cord-270469-lle32mha	243	41	the	the	DT
cord-270469-lle32mha	243	42	unfolded	unfolded	JJ
cord-270469-lle32mha	243	43	protein	protein	NN
cord-270469-lle32mha	243	44	response	response	NN
cord-270469-lle32mha	243	45	are	be	VBP
cord-270469-lle32mha	243	46	linked	link	VBN
cord-270469-lle32mha	243	47	to	to	IN
cord-270469-lle32mha	243	48	synergistic	synergistic	JJ
cord-270469-lle32mha	243	49	IFN	IFN	NNP
cord-270469-lle32mha	243	50	-	-	HYPH
cord-270469-lle32mha	243	51	beta	beta	NN
cord-270469-lle32mha	243	52	induction	induction	NN
cord-270469-lle32mha	243	53	via	via	IN
cord-270469-lle32mha	243	54	X	x	NN
cord-270469-lle32mha	243	55	-	-	HYPH
cord-270469-lle32mha	243	56	box	box	NN
cord-270469-lle32mha	243	57	binding	bind	VBG
cord-270469-lle32mha	243	58	protein	protein	NN
cord-270469-lle32mha	243	59	1	1	CD
cord-270469-lle32mha	243	60	Integration	Integration	NNP
cord-270469-lle32mha	243	61	of	of	IN
cord-270469-lle32mha	243	62	ER	ER	NNP
cord-270469-lle32mha	243	63	stress	stress	NN
cord-270469-lle32mha	243	64	and	and	CC
cord-270469-lle32mha	243	65	viral	viral	JJ
cord-270469-lle32mha	243	66	nucleotide	nucleotide	JJ
cord-270469-lle32mha	243	67	sensing	sensing	NN
cord-270469-lle32mha	243	68	in	in	IN
cord-270469-lle32mha	243	69	DCs	DCs	NNP
cord-270469-lle32mha	243	70	:	:	:
cord-270469-lle32mha	243	71	mounting	mount	VBG
cord-270469-lle32mha	243	72	a	a	DT
cord-270469-lle32mha	243	73	response	response	NN
cord-270469-lle32mha	243	74	commensurate	commensurate	NN
cord-270469-lle32mha	243	75	to	to	IN
cord-270469-lle32mha	243	76	the	the	DT
cord-270469-lle32mha	243	77	threat	threat	NN
cord-270469-lle32mha	243	78	?	?	.
cord-270469-lle32mha	244	1	Fine	fine	JJ
cord-270469-lle32mha	244	2	-	-	HYPH
cord-270469-lle32mha	244	3	tuning	tuning	NN
cord-270469-lle32mha	244	4	of	of	IN
cord-270469-lle32mha	244	5	the	the	DT
cord-270469-lle32mha	244	6	unfolded	unfolded	JJ
cord-270469-lle32mha	244	7	protein	protein	NN
cord-270469-lle32mha	244	8	response	response	NN
cord-270469-lle32mha	244	9	:	:	:
cord-270469-lle32mha	244	10	assembling	assemble	VBG
cord-270469-lle32mha	244	11	the	the	DT
cord-270469-lle32mha	244	12	IRE1a	IRE1a	NNP
cord-270469-lle32mha	244	13	Interactome	Interactome	NNP
cord-270469-lle32mha	244	14	Endoplasmic	Endoplasmic	NNP
cord-270469-lle32mha	244	15	reticulum	reticulum	NN
cord-270469-lle32mha	244	16	stress	stress	NN
cord-270469-lle32mha	244	17	-	-	HYPH
cord-270469-lle32mha	244	18	induced	induce	VBN
cord-270469-lle32mha	244	19	transcription	transcription	NN
cord-270469-lle32mha	244	20	factor	factor	NN
cord-270469-lle32mha	244	21	,	,	,
cord-270469-lle32mha	244	22	CHOP	CHOP	NNP
cord-270469-lle32mha	244	23	,	,	,
cord-270469-lle32mha	244	24	is	be	VBZ
cord-270469-lle32mha	244	25	crucial	crucial	JJ
cord-270469-lle32mha	244	26	for	for	IN
cord-270469-lle32mha	244	27	dendritic	dendritic	JJ
cord-270469-lle32mha	244	28	cell	cell	NN
cord-270469-lle32mha	244	29	IL-23	IL-23	NNP
cord-270469-lle32mha	244	30	expression	expression	NN
cord-270469-lle32mha	244	31	Plasma	plasma	NN
cord-270469-lle32mha	244	32	cell	cell	NN
cord-270469-lle32mha	244	33	differentiation	differentiation	NN
cord-270469-lle32mha	244	34	requires	require	VBZ
cord-270469-lle32mha	244	35	the	the	DT
cord-270469-lle32mha	244	36	transcription	transcription	NN
cord-270469-lle32mha	244	37	factor	factor	NN
cord-270469-lle32mha	244	38	XBP-1	XBP-1	NNP
cord-270469-lle32mha	244	39	From	from	IN
cord-270469-lle32mha	244	40	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	244	41	-	-	HYPH
cord-270469-lle32mha	244	42	reticulum	reticulum	NN
cord-270469-lle32mha	244	43	stress	stress	NN
cord-270469-lle32mha	244	44	to	to	IN
cord-270469-lle32mha	244	45	the	the	DT
cord-270469-lle32mha	244	46	inflammatory	inflammatory	JJ
cord-270469-lle32mha	244	47	response	response	NN
cord-270469-lle32mha	244	48	Plasma	plasma	NN
cord-270469-lle32mha	244	49	cell	cell	NN
cord-270469-lle32mha	244	50	differentiation	differentiation	NN
cord-270469-lle32mha	244	51	and	and	CC
cord-270469-lle32mha	244	52	the	the	DT
cord-270469-lle32mha	244	53	unfolded	unfold	VBN
cord-270469-lle32mha	244	54	protein	protein	NN
cord-270469-lle32mha	244	55	response	response	NN
cord-270469-lle32mha	244	56	intersect	intersect	VBP
cord-270469-lle32mha	244	57	at	at	IN
cord-270469-lle32mha	244	58	the	the	DT
cord-270469-lle32mha	244	59	transcription	transcription	NN
cord-270469-lle32mha	244	60	factor	factor	NN
cord-270469-lle32mha	245	1	XBP-1	XBP-1	NNP
cord-270469-lle32mha	245	2	Transmission	Transmission	NNP
cord-270469-lle32mha	245	3	of	of	IN
cord-270469-lle32mha	245	4	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	245	5	reticulum	reticulum	NN
cord-270469-lle32mha	245	6	stress	stress	NN
cord-270469-lle32mha	245	7	and	and	CC
cord-270469-lle32mha	245	8	proinflammation	proinflammation	NN
cord-270469-lle32mha	245	9	from	from	IN
cord-270469-lle32mha	245	10	tumor	tumor	NN
cord-270469-lle32mha	245	11	cells	cell	NNS
cord-270469-lle32mha	245	12	to	to	IN
cord-270469-lle32mha	245	13	myeloid	myeloid	NN
cord-270469-lle32mha	245	14	cells	cell	NNS
cord-270469-lle32mha	245	15	XBP-1	XBP-1	NNP
cord-270469-lle32mha	245	16	regulates	regulate	VBZ
cord-270469-lle32mha	245	17	signal	signal	NN
cord-270469-lle32mha	245	18	transduction	transduction	NN
cord-270469-lle32mha	245	19	,	,	,
cord-270469-lle32mha	245	20	transcription	transcription	NN
cord-270469-lle32mha	245	21	factors	factor	NNS
cord-270469-lle32mha	245	22	and	and	CC
cord-270469-lle32mha	245	23	bone	bone	NN
cord-270469-lle32mha	245	24	marrow	marrow	NN
cord-270469-lle32mha	245	25	colonization	colonization	NN
cord-270469-lle32mha	245	26	in	in	IN
cord-270469-lle32mha	245	27	B	b	NN
cord-270469-lle32mha	245	28	cells	cell	NNS
cord-270469-lle32mha	246	1	Regulated	regulated	JJ
cord-270469-lle32mha	246	2	Ire1-dependent	ire1-dependent	NN
cord-270469-lle32mha	246	3	decay	decay	NN
cord-270469-lle32mha	246	4	of	of	IN
cord-270469-lle32mha	246	5	messenger	messenger	NN
cord-270469-lle32mha	246	6	RNAs	rna	NNS
cord-270469-lle32mha	246	7	in	in	IN
cord-270469-lle32mha	246	8	mammalian	mammalian	JJ
cord-270469-lle32mha	246	9	cells	cell	NNS
cord-270469-lle32mha	246	10	IRE1alpha	ire1alpha	NN
cord-270469-lle32mha	246	11	kinase	kinase	VBP
cord-270469-lle32mha	246	12	activation	activation	NN
cord-270469-lle32mha	246	13	modes	mode	NNS
cord-270469-lle32mha	247	1	control	control	VB
cord-270469-lle32mha	247	2	alternate	alternate	JJ
cord-270469-lle32mha	247	3	endoribonuclease	endoribonuclease	NN
cord-270469-lle32mha	247	4	outputs	output	NNS
cord-270469-lle32mha	247	5	to	to	TO
cord-270469-lle32mha	247	6	determine	determine	VB
cord-270469-lle32mha	247	7	divergent	divergent	JJ
cord-270469-lle32mha	247	8	cell	cell	NN
cord-270469-lle32mha	247	9	fates	fate	NNS
cord-270469-lle32mha	247	10	Tumor	tumor	NN
cord-270469-lle32mha	247	11	stress	stress	NN
cord-270469-lle32mha	247	12	inside	inside	IN
cord-270469-lle32mha	247	13	out	out	IN
cord-270469-lle32mha	247	14	:	:	:
cord-270469-lle32mha	247	15	cell	cell	NN
cord-270469-lle32mha	247	16	-	-	HYPH
cord-270469-lle32mha	247	17	extrinsic	extrinsic	JJ
cord-270469-lle32mha	247	18	effects	effect	NNS
cord-270469-lle32mha	247	19	of	of	IN
cord-270469-lle32mha	247	20	the	the	DT
cord-270469-lle32mha	247	21	unfolded	unfolded	JJ
cord-270469-lle32mha	247	22	protein	protein	NN
cord-270469-lle32mha	247	23	response	response	NN
cord-270469-lle32mha	247	24	in	in	IN
cord-270469-lle32mha	247	25	tumor	tumor	NN
cord-270469-lle32mha	247	26	cells	cell	NNS
cord-270469-lle32mha	247	27	modulate	modulate	VBP
cord-270469-lle32mha	247	28	the	the	DT
cord-270469-lle32mha	247	29	immunological	immunological	JJ
cord-270469-lle32mha	247	30	landscape	landscape	NN
cord-270469-lle32mha	247	31	of	of	IN
cord-270469-lle32mha	247	32	the	the	DT
cord-270469-lle32mha	247	33	tumor	tumor	NN
cord-270469-lle32mha	247	34	microenvironment	microenvironment	NN
cord-270469-lle32mha	247	35	Molecular	molecular	JJ
cord-270469-lle32mha	247	36	determinants	determinant	NNS
cord-270469-lle32mha	247	37	of	of	IN
cord-270469-lle32mha	247	38	immunogenic	immunogenic	JJ
cord-270469-lle32mha	247	39	cell	cell	NN
cord-270469-lle32mha	247	40	death	death	NN
cord-270469-lle32mha	247	41	elicited	elicit	VBN
cord-270469-lle32mha	247	42	by	by	IN
cord-270469-lle32mha	248	1	anticancer	anticancer	JJ
cord-270469-lle32mha	248	2	chemotherapy	chemotherapy	NN
cord-270469-lle32mha	248	3	Proud	proud	JJ
cord-270469-lle32mha	248	4	,	,	,
cord-270469-lle32mha	249	1	eIF2	eIF2	NNP
cord-270469-lle32mha	249	2	and	and	CC
cord-270469-lle32mha	249	3	the	the	DT
cord-270469-lle32mha	249	4	control	control	NN
cord-270469-lle32mha	249	5	of	of	IN
cord-270469-lle32mha	249	6	cell	cell	NN
cord-270469-lle32mha	249	7	physiology	physiology	NN
cord-270469-lle32mha	249	8	Autophagy	autophagy	NN
cord-270469-lle32mha	249	9	-	-	HYPH
cord-270469-lle32mha	249	10	dependent	dependent	JJ
cord-270469-lle32mha	249	11	anticancer	anticancer	JJ
cord-270469-lle32mha	249	12	immune	immune	JJ
cord-270469-lle32mha	249	13	responses	response	NNS
cord-270469-lle32mha	249	14	induced	induce	VBN
cord-270469-lle32mha	249	15	by	by	IN
cord-270469-lle32mha	249	16	chemotherapeutic	chemotherapeutic	JJ
cord-270469-lle32mha	249	17	agents	agent	NNS
cord-270469-lle32mha	249	18	in	in	IN
cord-270469-lle32mha	249	19	mice	mouse	NNS
cord-270469-lle32mha	250	1	Calreticulin	calreticulin	JJ
cord-270469-lle32mha	250	2	exposure	exposure	NN
cord-270469-lle32mha	250	3	dictates	dictate	VBZ
cord-270469-lle32mha	250	4	the	the	DT
cord-270469-lle32mha	250	5	immunogenicity	immunogenicity	NN
cord-270469-lle32mha	250	6	of	of	IN
cord-270469-lle32mha	250	7	cancer	cancer	NN
cord-270469-lle32mha	250	8	cell	cell	NN
cord-270469-lle32mha	250	9	death	death	NN
cord-270469-lle32mha	251	1	The	the	DT
cord-270469-lle32mha	251	2	PERK	perk	NN
cord-270469-lle32mha	251	3	/	/	SYM
cord-270469-lle32mha	251	4	eIF2alpha	eif2alpha	NN
cord-270469-lle32mha	251	5	/	/	SYM
cord-270469-lle32mha	251	6	ATF4	ATF4	NNP
cord-270469-lle32mha	251	7	module	module	NN
cord-270469-lle32mha	251	8	of	of	IN
cord-270469-lle32mha	251	9	the	the	DT
cord-270469-lle32mha	251	10	UPR	UPR	NNP
cord-270469-lle32mha	251	11	in	in	IN
cord-270469-lle32mha	251	12	hypoxia	hypoxia	NN
cord-270469-lle32mha	251	13	resistance	resistance	NN
cord-270469-lle32mha	251	14	and	and	CC
cord-270469-lle32mha	251	15	tumor	tumor	NN
cord-270469-lle32mha	251	16	growth	growth	NN
cord-270469-lle32mha	252	1	A	a	DT
cord-270469-lle32mha	252	2	novel	novel	JJ
cord-270469-lle32mha	252	3	pathway	pathway	NN
cord-270469-lle32mha	252	4	combining	combine	VBG
cord-270469-lle32mha	252	5	calreticulin	calreticulin	NNP
cord-270469-lle32mha	252	6	exposure	exposure	NN
cord-270469-lle32mha	252	7	and	and	CC
cord-270469-lle32mha	252	8	ATP	ATP	NNP
cord-270469-lle32mha	252	9	secretion	secretion	NN
cord-270469-lle32mha	252	10	in	in	IN
cord-270469-lle32mha	252	11	immunogenic	immunogenic	JJ
cord-270469-lle32mha	252	12	cancer	cancer	NN
cord-270469-lle32mha	252	13	cell	cell	NN
cord-270469-lle32mha	252	14	death	death	NN
cord-270469-lle32mha	253	1	Activating	activate	VBG
cord-270469-lle32mha	253	2	transcription	transcription	NN
cord-270469-lle32mha	253	3	factor	factor	NN
cord-270469-lle32mha	253	4	4	4	CD
cord-270469-lle32mha	253	5	Mechanisms	Mechanisms	NNPS
cord-270469-lle32mha	253	6	of	of	IN
cord-270469-lle32mha	253	7	pre	pre	JJ
cord-270469-lle32mha	253	8	-	-	JJ
cord-270469-lle32mha	253	9	apoptotic	apoptotic	JJ
cord-270469-lle32mha	253	10	calreticulin	calreticulin	NN
cord-270469-lle32mha	253	11	exposure	exposure	NN
cord-270469-lle32mha	253	12	in	in	IN
cord-270469-lle32mha	254	1	immunogenic	immunogenic	JJ
cord-270469-lle32mha	254	2	cell	cell	NN
cord-270469-lle32mha	254	3	death	death	NN
cord-270469-lle32mha	254	4	Nrf2	Nrf2	NNP
cord-270469-lle32mha	254	5	is	be	VBZ
cord-270469-lle32mha	254	6	a	a	DT
cord-270469-lle32mha	254	7	critical	critical	JJ
cord-270469-lle32mha	254	8	regulator	regulator	NN
cord-270469-lle32mha	254	9	of	of	IN
cord-270469-lle32mha	254	10	the	the	DT
cord-270469-lle32mha	254	11	innate	innate	JJ
cord-270469-lle32mha	254	12	immune	immune	JJ
cord-270469-lle32mha	254	13	response	response	NN
cord-270469-lle32mha	254	14	and	and	CC
cord-270469-lle32mha	254	15	survival	survival	NN
cord-270469-lle32mha	254	16	during	during	IN
cord-270469-lle32mha	254	17	experimental	experimental	JJ
cord-270469-lle32mha	254	18	sepsis	sepsis	NN
cord-270469-lle32mha	254	19	Coordination	Coordination	NNP
cord-270469-lle32mha	254	20	of	of	IN
cord-270469-lle32mha	254	21	ER	ER	NNP
cord-270469-lle32mha	254	22	and	and	CC
cord-270469-lle32mha	254	23	oxidative	oxidative	JJ
cord-270469-lle32mha	254	24	stress	stress	NN
cord-270469-lle32mha	254	25	signaling	signaling	NN
cord-270469-lle32mha	254	26	:	:	:
cord-270469-lle32mha	255	1	the	the	DT
cord-270469-lle32mha	255	2	PERK	PERK	NNP
cord-270469-lle32mha	255	3	/	/	SYM
cord-270469-lle32mha	255	4	Nrf2	Nrf2	NNP
cord-270469-lle32mha	255	5	signaling	signal	VBG
cord-270469-lle32mha	255	6	pathway	pathway	NN
cord-270469-lle32mha	255	7	Selective	selective	JJ
cord-270469-lle32mha	255	8	activation	activation	NN
cord-270469-lle32mha	255	9	of	of	IN
cord-270469-lle32mha	255	10	the	the	DT
cord-270469-lle32mha	255	11	transcription	transcription	NN
cord-270469-lle32mha	255	12	factor	factor	NN
cord-270469-lle32mha	255	13	ATF6	ATF6	NNP
cord-270469-lle32mha	255	14	mediates	mediate	VBZ
cord-270469-lle32mha	255	15	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	255	16	reticulum	reticulum	NN
cord-270469-lle32mha	255	17	proliferation	proliferation	NN
cord-270469-lle32mha	255	18	triggered	trigger	VBN
cord-270469-lle32mha	255	19	by	by	IN
cord-270469-lle32mha	255	20	a	a	DT
cord-270469-lle32mha	255	21	membrane	membrane	NN
cord-270469-lle32mha	255	22	protein	protein	NN
cord-270469-lle32mha	255	23	ATF6alpha	ATF6alpha	NNP
cord-270469-lle32mha	255	24	optimizes	optimize	VBZ
cord-270469-lle32mha	255	25	long	long	JJ
cord-270469-lle32mha	255	26	-	-	HYPH
cord-270469-lle32mha	255	27	term	term	NN
cord-270469-lle32mha	255	28	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	255	29	reticulum	reticulum	NN
cord-270469-lle32mha	255	30	function	function	NN
cord-270469-lle32mha	255	31	to	to	TO
cord-270469-lle32mha	255	32	protect	protect	VB
cord-270469-lle32mha	255	33	cells	cell	NNS
cord-270469-lle32mha	255	34	from	from	IN
cord-270469-lle32mha	255	35	chronic	chronic	JJ
cord-270469-lle32mha	255	36	stress	stress	NN
cord-270469-lle32mha	255	37	Transcriptional	Transcriptional	NNP
cord-270469-lle32mha	255	38	induction	induction	NN
cord-270469-lle32mha	255	39	of	of	IN
cord-270469-lle32mha	255	40	mammalian	mammalian	JJ
cord-270469-lle32mha	255	41	ER	ER	NNP
cord-270469-lle32mha	255	42	quality	quality	NN
cord-270469-lle32mha	255	43	control	control	NN
cord-270469-lle32mha	255	44	proteins	protein	NNS
cord-270469-lle32mha	255	45	is	be	VBZ
cord-270469-lle32mha	255	46	mediated	mediate	VBN
cord-270469-lle32mha	255	47	by	by	IN
cord-270469-lle32mha	255	48	single	single	JJ
cord-270469-lle32mha	255	49	or	or	CC
cord-270469-lle32mha	255	50	combined	combined	JJ
cord-270469-lle32mha	255	51	action	action	NN
cord-270469-lle32mha	255	52	of	of	IN
cord-270469-lle32mha	255	53	ATF6alpha	ATF6alpha	NNP
cord-270469-lle32mha	255	54	and	and	CC
cord-270469-lle32mha	255	55	XBP1	XBP1	NNP
cord-270469-lle32mha	256	1	The	the	DT
cord-270469-lle32mha	256	2	interplay	interplay	NN
cord-270469-lle32mha	256	3	between	between	IN
cord-270469-lle32mha	256	4	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	256	5	reticulum	reticulum	NN
cord-270469-lle32mha	256	6	stress	stress	NN
cord-270469-lle32mha	256	7	and	and	CC
cord-270469-lle32mha	256	8	inflammation	inflammation	NN
cord-270469-lle32mha	256	9	NtbZIP60	NtbZIP60	NNS
cord-270469-lle32mha	256	10	,	,	,
cord-270469-lle32mha	256	11	an	an	DT
cord-270469-lle32mha	256	12	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	256	13	reticulum	reticulum	NN
cord-270469-lle32mha	256	14	-	-	HYPH
cord-270469-lle32mha	256	15	localized	localize	VBN
cord-270469-lle32mha	256	16	transcription	transcription	NN
cord-270469-lle32mha	256	17	factor	factor	NN
cord-270469-lle32mha	256	18	,	,	,
cord-270469-lle32mha	256	19	plays	play	VBZ
cord-270469-lle32mha	256	20	a	a	DT
cord-270469-lle32mha	256	21	role	role	NN
cord-270469-lle32mha	256	22	in	in	IN
cord-270469-lle32mha	256	23	the	the	DT
cord-270469-lle32mha	256	24	defense	defense	NN
cord-270469-lle32mha	256	25	response	response	NN
cord-270469-lle32mha	256	26	against	against	IN
cord-270469-lle32mha	256	27	bacterial	bacterial	JJ
cord-270469-lle32mha	256	28	pathogens	pathogen	NNS
cord-270469-lle32mha	256	29	in	in	IN
cord-270469-lle32mha	256	30	Nicotiana	Nicotiana	NNP
cord-270469-lle32mha	256	31	tabacum	tabacum	NNP
cord-270469-lle32mha	256	32	Activation	Activation	NNP
cord-270469-lle32mha	256	33	of	of	IN
cord-270469-lle32mha	256	34	the	the	DT
cord-270469-lle32mha	256	35	unfolded	unfolded	JJ
cord-270469-lle32mha	256	36	protein	protein	NN
cord-270469-lle32mha	256	37	response	response	NN
cord-270469-lle32mha	256	38	is	be	VBZ
cord-270469-lle32mha	256	39	required	require	VBN
cord-270469-lle32mha	256	40	for	for	IN
cord-270469-lle32mha	256	41	defenses	defense	NNS
cord-270469-lle32mha	256	42	against	against	IN
cord-270469-lle32mha	256	43	bacterial	bacterial	JJ
cord-270469-lle32mha	256	44	pore	pore	NN
cord-270469-lle32mha	256	45	-	-	HYPH
cord-270469-lle32mha	256	46	forming	form	VBG
cord-270469-lle32mha	256	47	toxin	toxin	NN
cord-270469-lle32mha	256	48	in	in	IN
cord-270469-lle32mha	256	49	vivo	vivo	NNP
cord-270469-lle32mha	256	50	An	an	DT
cord-270469-lle32mha	256	51	essential	essential	JJ
cord-270469-lle32mha	256	52	role	role	NN
cord-270469-lle32mha	256	53	for	for	IN
cord-270469-lle32mha	256	54	XBP-1	XBP-1	NNP
cord-270469-lle32mha	256	55	in	in	IN
cord-270469-lle32mha	256	56	host	host	NN
cord-270469-lle32mha	256	57	protection	protection	NN
cord-270469-lle32mha	256	58	against	against	IN
cord-270469-lle32mha	256	59	immune	immune	JJ
cord-270469-lle32mha	256	60	activation	activation	NN
cord-270469-lle32mha	256	61	in	in	IN
cord-270469-lle32mha	256	62	C.	C.	NNP
cord-270469-lle32mha	256	63	elegans	elegan	NNS
cord-270469-lle32mha	257	1	Physiological	physiological	JJ
cord-270469-lle32mha	257	2	IRE-1-XBP-1	IRE-1-XBP-1	NNP
cord-270469-lle32mha	257	3	and	and	CC
cord-270469-lle32mha	257	4	PEK-1	PEK-1	NNP
cord-270469-lle32mha	257	5	signaling	signal	VBG
cord-270469-lle32mha	257	6	in	in	IN
cord-270469-lle32mha	257	7	Caenorhabditis	Caenorhabditis	NNP
cord-270469-lle32mha	257	8	elegans	elegan	NNS
cord-270469-lle32mha	257	9	larval	larval	JJ
cord-270469-lle32mha	257	10	development	development	NN
cord-270469-lle32mha	257	11	and	and	CC
cord-270469-lle32mha	257	12	immunity	immunity	NN
cord-270469-lle32mha	257	13	Viruses	virus	NNS
cord-270469-lle32mha	257	14	,	,	,
cord-270469-lle32mha	257	15	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	257	16	reticulum	reticulum	NN
cord-270469-lle32mha	257	17	stress	stress	NN
cord-270469-lle32mha	257	18	,	,	,
cord-270469-lle32mha	257	19	and	and	CC
cord-270469-lle32mha	257	20	interferon	interferon	NN
cord-270469-lle32mha	257	21	responses	response	NNS
cord-270469-lle32mha	258	1	Inflammation	inflammation	NN
cord-270469-lle32mha	258	2	and	and	CC
cord-270469-lle32mha	258	3	epithelial	epithelial	JJ
cord-270469-lle32mha	258	4	cell	cell	NN
cord-270469-lle32mha	258	5	injury	injury	NN
cord-270469-lle32mha	258	6	in	in	IN
cord-270469-lle32mha	258	7	AIDS	AIDS	NNP
cord-270469-lle32mha	258	8	enteropathy	enteropathy	NNP
cord-270469-lle32mha	258	9	:	:	:
cord-270469-lle32mha	258	10	involvement	involvement	NN
cord-270469-lle32mha	258	11	of	of	IN
cord-270469-lle32mha	258	12	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	258	13	reticulum	reticulum	NN
cord-270469-lle32mha	258	14	stress	stress	NN
cord-270469-lle32mha	258	15	In	in	IN
cord-270469-lle32mha	258	16	vivo	vivo	NN
cord-270469-lle32mha	258	17	hepatic	hepatic	JJ
cord-270469-lle32mha	258	18	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	258	19	reticulum	reticulum	NN
cord-270469-lle32mha	258	20	stress	stress	NN
cord-270469-lle32mha	258	21	in	in	IN
cord-270469-lle32mha	258	22	patients	patient	NNS
cord-270469-lle32mha	258	23	with	with	IN
cord-270469-lle32mha	258	24	chronic	chronic	JJ
cord-270469-lle32mha	258	25	hepatitis	hepatitis	NN
cord-270469-lle32mha	258	26	C	c	NN
cord-270469-lle32mha	258	27	ATF6beta	ATF6beta	NNP
cord-270469-lle32mha	258	28	is	be	VBZ
cord-270469-lle32mha	258	29	a	a	DT
cord-270469-lle32mha	258	30	host	host	NN
cord-270469-lle32mha	258	31	cellular	cellular	JJ
cord-270469-lle32mha	258	32	target	target	NN
cord-270469-lle32mha	258	33	of	of	IN
cord-270469-lle32mha	258	34	the	the	DT
cord-270469-lle32mha	258	35	Toxoplasma	toxoplasma	JJ
cord-270469-lle32mha	258	36	gondii	gondii	NN
cord-270469-lle32mha	258	37	virulence	virulence	NN
cord-270469-lle32mha	258	38	factor	factor	NN
cord-270469-lle32mha	258	39	ROP18	ROP18	NNP
cord-270469-lle32mha	258	40	Induction	Induction	NNP
cord-270469-lle32mha	258	41	of	of	IN
cord-270469-lle32mha	258	42	ER	ER	NNP
cord-270469-lle32mha	258	43	stress	stress	NN
cord-270469-lle32mha	258	44	in	in	IN
cord-270469-lle32mha	258	45	macrophages	macrophage	NNS
cord-270469-lle32mha	258	46	of	of	IN
cord-270469-lle32mha	258	47	tuberculosis	tuberculosis	NN
cord-270469-lle32mha	258	48	granulomas	granuloma	NNS
cord-270469-lle32mha	258	49	Activation	activation	NN
cord-270469-lle32mha	258	50	of	of	IN
cord-270469-lle32mha	258	51	the	the	DT
cord-270469-lle32mha	258	52	unfolded	unfolded	JJ
cord-270469-lle32mha	258	53	protein	protein	NN
cord-270469-lle32mha	258	54	response	response	NN
cord-270469-lle32mha	258	55	by	by	IN
cord-270469-lle32mha	258	56	Listeria	Listeria	NNP
cord-270469-lle32mha	258	57	monocytogenes	monocytogenes	NNP
cord-270469-lle32mha	258	58	Influenza	Influenza	NNP
cord-270469-lle32mha	258	59	A	a	DT
cord-270469-lle32mha	258	60	viral	viral	JJ
cord-270469-lle32mha	258	61	replication	replication	NN
cord-270469-lle32mha	258	62	is	be	VBZ
cord-270469-lle32mha	258	63	blocked	block	VBN
cord-270469-lle32mha	258	64	by	by	IN
cord-270469-lle32mha	258	65	inhibition	inhibition	NN
cord-270469-lle32mha	258	66	of	of	IN
cord-270469-lle32mha	258	67	the	the	DT
cord-270469-lle32mha	258	68	inositol	inositol	NN
cord-270469-lle32mha	258	69	-	-	HYPH
cord-270469-lle32mha	258	70	requiring	require	VBG
cord-270469-lle32mha	258	71	enzyme	enzyme	NN
cord-270469-lle32mha	258	72	1	1	CD
cord-270469-lle32mha	259	1	(	(	-LRB-
cord-270469-lle32mha	259	2	IRE1	IRE1	NNP
cord-270469-lle32mha	259	3	)	)	-RRB-
cord-270469-lle32mha	259	4	stress	stress	NN
cord-270469-lle32mha	259	5	pathway	pathway	NN
cord-270469-lle32mha	259	6	Role	role	NN
cord-270469-lle32mha	259	7	of	of	IN
cord-270469-lle32mha	259	8	the	the	DT
cord-270469-lle32mha	259	9	host	host	NN
cord-270469-lle32mha	259	10	cell	cell	NN
cord-270469-lle32mha	259	11	's	's	POS
cord-270469-lle32mha	259	12	unfolded	unfold	VBN
cord-270469-lle32mha	259	13	protein	protein	NN
cord-270469-lle32mha	259	14	response	response	NN
cord-270469-lle32mha	259	15	in	in	IN
cord-270469-lle32mha	259	16	arenavirus	arenavirus	NNP
cord-270469-lle32mha	259	17	infection	infection	NN
cord-270469-lle32mha	259	18	Adaptive	adaptive	JJ
cord-270469-lle32mha	259	19	suppression	suppression	NN
cord-270469-lle32mha	259	20	of	of	IN
cord-270469-lle32mha	259	21	the	the	DT
cord-270469-lle32mha	259	22	ATF4-CHOP	atf4-chop	DT
cord-270469-lle32mha	259	23	branch	branch	NN
cord-270469-lle32mha	259	24	of	of	IN
cord-270469-lle32mha	259	25	the	the	DT
cord-270469-lle32mha	259	26	unfolded	unfolded	JJ
cord-270469-lle32mha	259	27	protein	protein	NN
cord-270469-lle32mha	259	28	response	response	NN
cord-270469-lle32mha	259	29	by	by	IN
cord-270469-lle32mha	259	30	toll	toll	NN
cord-270469-lle32mha	259	31	-	-	HYPH
cord-270469-lle32mha	259	32	like	like	JJ
cord-270469-lle32mha	259	33	receptor	receptor	NN
cord-270469-lle32mha	259	34	signaling	signal	VBG
cord-270469-lle32mha	259	35	Toll	Toll	NNP
cord-270469-lle32mha	259	36	-	-	HYPH
cord-270469-lle32mha	259	37	like	like	JJ
cord-270469-lle32mha	259	38	receptor	receptor	NN
cord-270469-lle32mha	259	39	activation	activation	NN
cord-270469-lle32mha	259	40	suppresses	suppress	VBZ
cord-270469-lle32mha	259	41	ER	ER	NNP
cord-270469-lle32mha	259	42	stress	stress	NN
cord-270469-lle32mha	259	43	factor	factor	NN
cord-270469-lle32mha	259	44	CHOP	chop	NN
cord-270469-lle32mha	259	45	and	and	CC
cord-270469-lle32mha	259	46	translation	translation	NN
cord-270469-lle32mha	259	47	inhibition	inhibition	NN
cord-270469-lle32mha	259	48	through	through	IN
cord-270469-lle32mha	259	49	activation	activation	NN
cord-270469-lle32mha	259	50	of	of	IN
cord-270469-lle32mha	259	51	eIF2B	eif2b	CD
cord-270469-lle32mha	259	52	Dengue	Dengue	NNP
cord-270469-lle32mha	259	53	virus	virus	NN
cord-270469-lle32mha	259	54	modulates	modulate	VBZ
cord-270469-lle32mha	259	55	the	the	DT
cord-270469-lle32mha	259	56	unfolded	unfolded	JJ
cord-270469-lle32mha	259	57	protein	protein	NN
cord-270469-lle32mha	259	58	response	response	NN
cord-270469-lle32mha	259	59	in	in	IN
cord-270469-lle32mha	259	60	a	a	DT
cord-270469-lle32mha	259	61	time	time	NN
cord-270469-lle32mha	259	62	-	-	HYPH
cord-270469-lle32mha	259	63	dependent	dependent	JJ
cord-270469-lle32mha	259	64	manner	manner	NN
cord-270469-lle32mha	260	1	HCV	HCV	NNP
cord-270469-lle32mha	260	2	causes	cause	VBZ
cord-270469-lle32mha	260	3	chronic	chronic	JJ
cord-270469-lle32mha	260	4	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	260	5	reticulum	reticulum	NN
cord-270469-lle32mha	260	6	stress	stress	NN
cord-270469-lle32mha	260	7	leading	lead	VBG
cord-270469-lle32mha	260	8	to	to	IN
cord-270469-lle32mha	260	9	adaptation	adaptation	NN
cord-270469-lle32mha	260	10	and	and	CC
cord-270469-lle32mha	260	11	interference	interference	NN
cord-270469-lle32mha	260	12	with	with	IN
cord-270469-lle32mha	260	13	the	the	DT
cord-270469-lle32mha	260	14	unfolded	unfolded	JJ
cord-270469-lle32mha	260	15	protein	protein	NN
cord-270469-lle32mha	260	16	response	response	NN
cord-270469-lle32mha	260	17	Hepatitis	Hepatitis	NNP
cord-270469-lle32mha	260	18	C	C	NNP
cord-270469-lle32mha	260	19	virus	virus	NN
cord-270469-lle32mha	260	20	suppresses	suppress	VBZ
cord-270469-lle32mha	260	21	the	the	DT
cord-270469-lle32mha	260	22	IRE1-XBP1	IRE1-XBP1	NNP
cord-270469-lle32mha	260	23	pathway	pathway	NN
cord-270469-lle32mha	260	24	of	of	IN
cord-270469-lle32mha	260	25	the	the	DT
cord-270469-lle32mha	260	26	unfolded	unfolded	JJ
cord-270469-lle32mha	260	27	protein	protein	NN
cord-270469-lle32mha	260	28	response	response	NN
cord-270469-lle32mha	261	1	Protein	protein	NN
cord-270469-lle32mha	261	2	synthesis	synthesis	NN
cord-270469-lle32mha	261	3	and	and	CC
cord-270469-lle32mha	261	4	endoplasmic	endoplasmic	NN
cord-270469-lle32mha	261	5	reticulum	reticulum	NN
cord-270469-lle32mha	261	6	stress	stress	NN
cord-270469-lle32mha	261	7	can	can	MD
cord-270469-lle32mha	261	8	be	be	VB
cord-270469-lle32mha	261	9	modulated	modulate	VBN
cord-270469-lle32mha	261	10	by	by	IN
cord-270469-lle32mha	261	11	the	the	DT
cord-270469-lle32mha	261	12	hepatitis	hepatitis	NN
cord-270469-lle32mha	261	13	C	C	NNP
cord-270469-lle32mha	261	14	virus	virus	NN
cord-270469-lle32mha	261	15	envelope	envelope	NN
cord-270469-lle32mha	261	16	protein	protein	NN
cord-270469-lle32mha	261	17	E2	E2	NNP
cord-270469-lle32mha	261	18	through	through	IN
cord-270469-lle32mha	261	19	the	the	DT
cord-270469-lle32mha	261	20	eukaryotic	eukaryotic	JJ
cord-270469-lle32mha	261	21	initiation	initiation	NN
cord-270469-lle32mha	261	22	factor	factor	NN
cord-270469-lle32mha	261	23	2alpha	2alpha	CD
cord-270469-lle32mha	261	24	kinase	kinase	NN
cord-270469-lle32mha	261	25	PERK	perk	VBP
cord-270469-lle32mha	261	26	Coronavirus	Coronavirus	NNP
cord-270469-lle32mha	261	27	infection	infection	NN
cord-270469-lle32mha	261	28	modulates	modulate	VBZ
cord-270469-lle32mha	261	29	the	the	DT
cord-270469-lle32mha	261	30	unfolded	unfolded	JJ
cord-270469-lle32mha	261	31	protein	protein	NN
cord-270469-lle32mha	261	32	response	response	NN
cord-270469-lle32mha	261	33	and	and	CC
cord-270469-lle32mha	261	34	mediates	mediate	VBZ
cord-270469-lle32mha	261	35	sustained	sustain	VBN
cord-270469-lle32mha	261	36	translational	translational	JJ
cord-270469-lle32mha	261	37	repression	repression	NN
cord-270469-lle32mha	261	38	Endoplasmic	Endoplasmic	NNP
cord-270469-lle32mha	261	39	reticulum	reticulum	NN
cord-270469-lle32mha	261	40	stress	stress	NN
cord-270469-lle32mha	261	41	is	be	VBZ
cord-270469-lle32mha	261	42	induced	induce	VBN
cord-270469-lle32mha	261	43	and	and	CC
cord-270469-lle32mha	261	44	modulated	modulate	VBN
cord-270469-lle32mha	261	45	by	by	IN
cord-270469-lle32mha	261	46	enterovirus	enterovirus	NN
cord-270469-lle32mha	261	47	71	71	CD