id	sid	tid	token	lemma	pos
cord-257027-q2y7fewk	1	1	key	key	JJ
cord-257027-q2y7fewk	1	2	:	:	:
cord-257027-q2y7fewk	1	3	cord-257027-q2y7fewk	cord-257027-q2y7fewk	IN
cord-257027-q2y7fewk	1	4	authors	author	NNS
cord-257027-q2y7fewk	1	5	:	:	:
cord-257027-q2y7fewk	1	6	Lemaire	Lemaire	NNP
cord-257027-q2y7fewk	1	7	,	,	,
cord-257027-q2y7fewk	1	8	D.	D.	NNP
cord-257027-q2y7fewk	1	9	;	;	:
cord-257027-q2y7fewk	1	10	Barbosa	Barbosa	NNP
cord-257027-q2y7fewk	1	11	,	,	,
cord-257027-q2y7fewk	1	12	T.	T.	NNP
cord-257027-q2y7fewk	1	13	;	;	:
cord-257027-q2y7fewk	1	14	Rihet	Rihet	NNP
cord-257027-q2y7fewk	1	15	,	,	,
cord-257027-q2y7fewk	1	16	P.	P.	NNP
cord-257027-q2y7fewk	1	17	title	title	NN
cord-257027-q2y7fewk	1	18	:	:	:
cord-257027-q2y7fewk	1	19	Coping	cope	VBG
cord-257027-q2y7fewk	1	20	with	with	IN
cord-257027-q2y7fewk	1	21	genetic	genetic	JJ
cord-257027-q2y7fewk	1	22	diversity	diversity	NN
cord-257027-q2y7fewk	1	23	:	:	:
cord-257027-q2y7fewk	1	24	the	the	DT
cord-257027-q2y7fewk	1	25	contribution	contribution	NN
cord-257027-q2y7fewk	1	26	of	of	IN
cord-257027-q2y7fewk	1	27	pathogen	pathogen	NN
cord-257027-q2y7fewk	1	28	and	and	CC
cord-257027-q2y7fewk	1	29	human	human	JJ
cord-257027-q2y7fewk	1	30	genomics	genomic	NNS
cord-257027-q2y7fewk	1	31	to	to	IN
cord-257027-q2y7fewk	1	32	modern	modern	JJ
cord-257027-q2y7fewk	1	33	vaccinology	vaccinology	NN
cord-257027-q2y7fewk	1	34	date	date	NN
cord-257027-q2y7fewk	1	35	:	:	:
cord-257027-q2y7fewk	1	36	2011	2011	CD
cord-257027-q2y7fewk	1	37	-	-	SYM
cord-257027-q2y7fewk	1	38	10	10	CD
cord-257027-q2y7fewk	1	39	-	-	SYM
cord-257027-q2y7fewk	1	40	28	28	CD
cord-257027-q2y7fewk	1	41	journal	journal	NN
cord-257027-q2y7fewk	1	42	:	:	:
cord-257027-q2y7fewk	1	43	Braz	Braz	NNP
cord-257027-q2y7fewk	1	44	J	J	NNP
cord-257027-q2y7fewk	1	45	Med	Med	NNP
cord-257027-q2y7fewk	1	46	Biol	Biol	NNP
cord-257027-q2y7fewk	1	47	Res	Res	NNP
cord-257027-q2y7fewk	1	48	DOI	DOI	NNP
cord-257027-q2y7fewk	1	49	:	:	:
cord-257027-q2y7fewk	1	50	10.1590	10.1590	CD
cord-257027-q2y7fewk	1	51	/	/	SYM
cord-257027-q2y7fewk	1	52	s0100	s0100	NN
cord-257027-q2y7fewk	1	53	-	-	HYPH
cord-257027-q2y7fewk	1	54	879x2011007500142	879x2011007500142	NN
cord-257027-q2y7fewk	1	55	sha	sha	NN
cord-257027-q2y7fewk	1	56	:	:	:
cord-257027-q2y7fewk	1	57	92dc5a63d0776632f789e874bb0217c4ac1d021b	92dc5a63d0776632f789e874bb0217c4ac1d021b	CD
cord-257027-q2y7fewk	1	58	doc_id	doc_id	CD
cord-257027-q2y7fewk	1	59	:	:	:
cord-257027-q2y7fewk	1	60	257027	257027	CD
cord-257027-q2y7fewk	1	61	cord_uid	cord_uid	NNS
cord-257027-q2y7fewk	1	62	:	:	:
cord-257027-q2y7fewk	1	63	q2y7fewk	q2y7fewk	.
cord-257027-q2y7fewk	2	1	Vaccine	vaccine	NN
cord-257027-q2y7fewk	2	2	development	development	NN
cord-257027-q2y7fewk	2	3	faces	face	VBZ
cord-257027-q2y7fewk	2	4	major	major	JJ
cord-257027-q2y7fewk	2	5	difficulties	difficulty	NNS
cord-257027-q2y7fewk	2	6	partly	partly	RB
cord-257027-q2y7fewk	2	7	because	because	IN
cord-257027-q2y7fewk	2	8	of	of	IN
cord-257027-q2y7fewk	2	9	genetic	genetic	JJ
cord-257027-q2y7fewk	2	10	variation	variation	NN
cord-257027-q2y7fewk	2	11	in	in	IN
cord-257027-q2y7fewk	2	12	both	both	CC
cord-257027-q2y7fewk	2	13	infectious	infectious	JJ
cord-257027-q2y7fewk	2	14	organisms	organism	NNS
cord-257027-q2y7fewk	2	15	and	and	CC
cord-257027-q2y7fewk	2	16	humans	human	NNS
cord-257027-q2y7fewk	2	17	.	.	.
cord-257027-q2y7fewk	3	1	This	this	DT
cord-257027-q2y7fewk	3	2	causes	cause	VBZ
cord-257027-q2y7fewk	3	3	antigenic	antigenic	JJ
cord-257027-q2y7fewk	3	4	variation	variation	NN
cord-257027-q2y7fewk	3	5	in	in	IN
cord-257027-q2y7fewk	3	6	infectious	infectious	JJ
cord-257027-q2y7fewk	3	7	agents	agent	NNS
cord-257027-q2y7fewk	3	8	and	and	CC
cord-257027-q2y7fewk	3	9	a	a	DT
cord-257027-q2y7fewk	3	10	high	high	JJ
cord-257027-q2y7fewk	3	11	interindividual	interindividual	JJ
cord-257027-q2y7fewk	3	12	variability	variability	NN
cord-257027-q2y7fewk	3	13	in	in	IN
cord-257027-q2y7fewk	3	14	the	the	DT
cord-257027-q2y7fewk	3	15	human	human	JJ
cord-257027-q2y7fewk	3	16	response	response	NN
cord-257027-q2y7fewk	3	17	to	to	IN
cord-257027-q2y7fewk	3	18	the	the	DT
cord-257027-q2y7fewk	3	19	vaccine	vaccine	NN
cord-257027-q2y7fewk	3	20	.	.	.
cord-257027-q2y7fewk	4	1	The	the	DT
cord-257027-q2y7fewk	4	2	exponential	exponential	JJ
cord-257027-q2y7fewk	4	3	growth	growth	NN
cord-257027-q2y7fewk	4	4	of	of	IN
cord-257027-q2y7fewk	4	5	genome	genome	NN
cord-257027-q2y7fewk	4	6	sequence	sequence	NN
cord-257027-q2y7fewk	4	7	information	information	NN
cord-257027-q2y7fewk	4	8	has	have	VBZ
cord-257027-q2y7fewk	4	9	induced	induce	VBN
cord-257027-q2y7fewk	4	10	a	a	DT
cord-257027-q2y7fewk	4	11	shift	shift	NN
cord-257027-q2y7fewk	4	12	from	from	IN
cord-257027-q2y7fewk	4	13	conventional	conventional	JJ
cord-257027-q2y7fewk	4	14	culture	culture	NN
cord-257027-q2y7fewk	4	15	-	-	HYPH
cord-257027-q2y7fewk	4	16	based	base	VBN
cord-257027-q2y7fewk	4	17	to	to	IN
cord-257027-q2y7fewk	4	18	genome	genome	NN
cord-257027-q2y7fewk	4	19	-	-	HYPH
cord-257027-q2y7fewk	4	20	based	base	VBN
cord-257027-q2y7fewk	4	21	vaccinology	vaccinology	NN
cord-257027-q2y7fewk	4	22	,	,	,
cord-257027-q2y7fewk	4	23	and	and	CC
cord-257027-q2y7fewk	4	24	allows	allow	VBZ
cord-257027-q2y7fewk	4	25	the	the	DT
cord-257027-q2y7fewk	4	26	tackling	tackling	NN
cord-257027-q2y7fewk	4	27	of	of	IN
cord-257027-q2y7fewk	4	28	challenges	challenge	NNS
cord-257027-q2y7fewk	4	29	in	in	IN
cord-257027-q2y7fewk	4	30	vaccine	vaccine	NN
cord-257027-q2y7fewk	4	31	development	development	NN
cord-257027-q2y7fewk	4	32	due	due	IN
cord-257027-q2y7fewk	4	33	to	to	IN
cord-257027-q2y7fewk	4	34	pathogen	pathogen	VB
cord-257027-q2y7fewk	4	35	genetic	genetic	JJ
cord-257027-q2y7fewk	4	36	variability	variability	NN
cord-257027-q2y7fewk	4	37	.	.	.
cord-257027-q2y7fewk	5	1	Additionally	additionally	RB
cord-257027-q2y7fewk	5	2	,	,	,
cord-257027-q2y7fewk	5	3	recent	recent	JJ
cord-257027-q2y7fewk	5	4	advances	advance	NNS
cord-257027-q2y7fewk	5	5	in	in	IN
cord-257027-q2y7fewk	5	6	immunogenetics	immunogenetic	NNS
cord-257027-q2y7fewk	5	7	and	and	CC
cord-257027-q2y7fewk	5	8	genomics	genomic	NNS
cord-257027-q2y7fewk	5	9	should	should	MD
cord-257027-q2y7fewk	5	10	help	help	VB
cord-257027-q2y7fewk	5	11	in	in	IN
cord-257027-q2y7fewk	5	12	the	the	DT
cord-257027-q2y7fewk	5	13	understanding	understanding	NN
cord-257027-q2y7fewk	5	14	of	of	IN
cord-257027-q2y7fewk	5	15	the	the	DT
cord-257027-q2y7fewk	5	16	influence	influence	NN
cord-257027-q2y7fewk	5	17	of	of	IN
cord-257027-q2y7fewk	5	18	genetic	genetic	JJ
cord-257027-q2y7fewk	5	19	factors	factor	NNS
cord-257027-q2y7fewk	5	20	on	on	IN
cord-257027-q2y7fewk	5	21	the	the	DT
cord-257027-q2y7fewk	5	22	interindividual	interindividual	NNP
cord-257027-q2y7fewk	5	23	and	and	CC
cord-257027-q2y7fewk	5	24	interpopulation	interpopulation	NN
cord-257027-q2y7fewk	5	25	variations	variation	NNS
cord-257027-q2y7fewk	5	26	in	in	IN
cord-257027-q2y7fewk	5	27	immune	immune	JJ
cord-257027-q2y7fewk	5	28	responses	response	NNS
cord-257027-q2y7fewk	5	29	to	to	IN
cord-257027-q2y7fewk	5	30	vaccines	vaccine	NNS
cord-257027-q2y7fewk	5	31	,	,	,
cord-257027-q2y7fewk	5	32	and	and	CC
cord-257027-q2y7fewk	5	33	could	could	MD
cord-257027-q2y7fewk	5	34	be	be	VB
cord-257027-q2y7fewk	5	35	useful	useful	JJ
cord-257027-q2y7fewk	5	36	for	for	IN
cord-257027-q2y7fewk	5	37	developing	develop	VBG
cord-257027-q2y7fewk	5	38	new	new	JJ
cord-257027-q2y7fewk	5	39	vaccine	vaccine	NN
cord-257027-q2y7fewk	5	40	strategies	strategy	NNS
cord-257027-q2y7fewk	5	41	.	.	.
cord-257027-q2y7fewk	6	1	Accumulating	accumulate	VBG
cord-257027-q2y7fewk	6	2	results	result	NNS
cord-257027-q2y7fewk	6	3	provide	provide	VBP
cord-257027-q2y7fewk	6	4	evidence	evidence	NN
cord-257027-q2y7fewk	6	5	for	for	IN
cord-257027-q2y7fewk	6	6	the	the	DT
cord-257027-q2y7fewk	6	7	existence	existence	NN
cord-257027-q2y7fewk	6	8	of	of	IN
cord-257027-q2y7fewk	6	9	a	a	DT
cord-257027-q2y7fewk	6	10	number	number	NN
cord-257027-q2y7fewk	6	11	of	of	IN
cord-257027-q2y7fewk	6	12	genes	gene	NNS
cord-257027-q2y7fewk	6	13	involved	involve	VBN
cord-257027-q2y7fewk	6	14	in	in	IN
cord-257027-q2y7fewk	6	15	protective	protective	JJ
cord-257027-q2y7fewk	6	16	immune	immune	JJ
cord-257027-q2y7fewk	6	17	responses	response	NNS
cord-257027-q2y7fewk	6	18	that	that	WDT
cord-257027-q2y7fewk	6	19	are	be	VBP
cord-257027-q2y7fewk	6	20	induced	induce	VBN
cord-257027-q2y7fewk	6	21	either	either	CC
cord-257027-q2y7fewk	6	22	by	by	IN
cord-257027-q2y7fewk	6	23	natural	natural	JJ
cord-257027-q2y7fewk	6	24	infections	infection	NNS
cord-257027-q2y7fewk	6	25	or	or	CC
cord-257027-q2y7fewk	6	26	vaccines	vaccine	NNS
cord-257027-q2y7fewk	6	27	.	.	.
cord-257027-q2y7fewk	7	1	Variation	variation	NN
cord-257027-q2y7fewk	7	2	in	in	IN
cord-257027-q2y7fewk	7	3	immune	immune	JJ
cord-257027-q2y7fewk	7	4	responses	response	NNS
cord-257027-q2y7fewk	7	5	could	could	MD
cord-257027-q2y7fewk	7	6	be	be	VB
cord-257027-q2y7fewk	7	7	viewed	view	VBN
cord-257027-q2y7fewk	7	8	as	as	IN
cord-257027-q2y7fewk	7	9	the	the	DT
cord-257027-q2y7fewk	7	10	result	result	NN
cord-257027-q2y7fewk	7	11	of	of	IN
cord-257027-q2y7fewk	7	12	a	a	DT
cord-257027-q2y7fewk	7	13	perturbation	perturbation	NN
cord-257027-q2y7fewk	7	14	of	of	IN
cord-257027-q2y7fewk	7	15	gene	gene	NN
cord-257027-q2y7fewk	7	16	networks	network	NNS
cord-257027-q2y7fewk	7	17	;	;	:
cord-257027-q2y7fewk	7	18	this	this	DT
cord-257027-q2y7fewk	7	19	should	should	MD
cord-257027-q2y7fewk	7	20	help	help	VB
cord-257027-q2y7fewk	7	21	in	in	IN
cord-257027-q2y7fewk	7	22	understanding	understand	VBG
cord-257027-q2y7fewk	7	23	how	how	WRB
cord-257027-q2y7fewk	7	24	a	a	DT
cord-257027-q2y7fewk	7	25	particular	particular	JJ
cord-257027-q2y7fewk	7	26	polymorphism	polymorphism	NN
cord-257027-q2y7fewk	7	27	or	or	CC
cord-257027-q2y7fewk	7	28	a	a	DT
cord-257027-q2y7fewk	7	29	combination	combination	NN
cord-257027-q2y7fewk	7	30	thereof	thereof	WDT
cord-257027-q2y7fewk	7	31	could	could	MD
cord-257027-q2y7fewk	7	32	affect	affect	VB
cord-257027-q2y7fewk	7	33	protective	protective	JJ
cord-257027-q2y7fewk	7	34	immune	immune	JJ
cord-257027-q2y7fewk	7	35	responses	response	NNS
cord-257027-q2y7fewk	7	36	.	.	.
cord-257027-q2y7fewk	8	1	Here	here	RB
cord-257027-q2y7fewk	8	2	we	-PRON-	PRP
cord-257027-q2y7fewk	8	3	will	will	MD
cord-257027-q2y7fewk	8	4	present	present	VB
cord-257027-q2y7fewk	8	5	:	:	.
cord-257027-q2y7fewk	9	1	i	i	PRP
cord-257027-q2y7fewk	9	2	)	)	-RRB-
cord-257027-q2y7fewk	9	3	the	the	DT
cord-257027-q2y7fewk	9	4	first	first	JJ
cord-257027-q2y7fewk	9	5	genome	genome	NN
cord-257027-q2y7fewk	9	6	-	-	HYPH
cord-257027-q2y7fewk	9	7	based	base	VBN
cord-257027-q2y7fewk	9	8	vaccines	vaccine	NNS
cord-257027-q2y7fewk	9	9	that	that	WDT
cord-257027-q2y7fewk	9	10	served	serve	VBD
cord-257027-q2y7fewk	9	11	as	as	IN
cord-257027-q2y7fewk	9	12	proof	proof	NN
cord-257027-q2y7fewk	9	13	of	of	IN
cord-257027-q2y7fewk	9	14	concept	concept	NN
cord-257027-q2y7fewk	9	15	,	,	,
cord-257027-q2y7fewk	9	16	and	and	CC
cord-257027-q2y7fewk	9	17	that	that	DT
cord-257027-q2y7fewk	9	18	provided	provide	VBD
cord-257027-q2y7fewk	9	19	new	new	JJ
cord-257027-q2y7fewk	9	20	critical	critical	JJ
cord-257027-q2y7fewk	9	21	insights	insight	NNS
cord-257027-q2y7fewk	9	22	into	into	IN
cord-257027-q2y7fewk	9	23	vaccine	vaccine	NN
cord-257027-q2y7fewk	9	24	development	development	NN
cord-257027-q2y7fewk	9	25	strategies	strategy	NNS
cord-257027-q2y7fewk	9	26	;	;	:
cord-257027-q2y7fewk	9	27	ii	ii	LS
cord-257027-q2y7fewk	9	28	)	)	-RRB-
cord-257027-q2y7fewk	9	29	an	an	DT
cord-257027-q2y7fewk	9	30	overview	overview	NN
cord-257027-q2y7fewk	9	31	of	of	IN
cord-257027-q2y7fewk	9	32	genetic	genetic	JJ
cord-257027-q2y7fewk	9	33	predisposition	predisposition	NN
cord-257027-q2y7fewk	9	34	in	in	IN
cord-257027-q2y7fewk	9	35	infectious	infectious	JJ
cord-257027-q2y7fewk	9	36	diseases	disease	NNS
cord-257027-q2y7fewk	9	37	and	and	CC
cord-257027-q2y7fewk	9	38	genetic	genetic	JJ
cord-257027-q2y7fewk	9	39	control	control	NN
cord-257027-q2y7fewk	9	40	in	in	IN
cord-257027-q2y7fewk	9	41	responses	response	NNS
cord-257027-q2y7fewk	9	42	to	to	IN
cord-257027-q2y7fewk	9	43	vaccines	vaccine	NNS
cord-257027-q2y7fewk	9	44	;	;	:
cord-257027-q2y7fewk	9	45	iii	iii	LS
cord-257027-q2y7fewk	9	46	)	)	-RRB-
cord-257027-q2y7fewk	9	47	population	population	NN
cord-257027-q2y7fewk	9	48	genetic	genetic	JJ
cord-257027-q2y7fewk	9	49	differences	difference	NNS
cord-257027-q2y7fewk	9	50	that	that	WDT
cord-257027-q2y7fewk	9	51	are	be	VBP
cord-257027-q2y7fewk	9	52	a	a	DT
cord-257027-q2y7fewk	9	53	rationale	rationale	NN
cord-257027-q2y7fewk	9	54	behind	behind	IN
cord-257027-q2y7fewk	9	55	group	group	NN
cord-257027-q2y7fewk	9	56	-	-	HYPH
cord-257027-q2y7fewk	9	57	targeted	target	VBN
cord-257027-q2y7fewk	9	58	vaccines	vaccine	NNS
cord-257027-q2y7fewk	9	59	;	;	:
cord-257027-q2y7fewk	10	1	iv	iv	LS
cord-257027-q2y7fewk	10	2	)	)	-RRB-
cord-257027-q2y7fewk	10	3	an	an	DT
cord-257027-q2y7fewk	10	4	outlook	outlook	NN
cord-257027-q2y7fewk	10	5	for	for	IN
cord-257027-q2y7fewk	10	6	genetic	genetic	JJ
cord-257027-q2y7fewk	10	7	control	control	NN
cord-257027-q2y7fewk	10	8	in	in	IN
cord-257027-q2y7fewk	10	9	infectious	infectious	JJ
cord-257027-q2y7fewk	10	10	diseases	disease	NNS
cord-257027-q2y7fewk	10	11	,	,	,
cord-257027-q2y7fewk	10	12	with	with	IN
cord-257027-q2y7fewk	10	13	special	special	JJ
cord-257027-q2y7fewk	10	14	emphasis	emphasis	NN
cord-257027-q2y7fewk	10	15	on	on	IN
cord-257027-q2y7fewk	10	16	the	the	DT
cord-257027-q2y7fewk	10	17	concept	concept	NN
cord-257027-q2y7fewk	10	18	of	of	IN
cord-257027-q2y7fewk	10	19	molecular	molecular	JJ
cord-257027-q2y7fewk	10	20	networks	network	NNS
cord-257027-q2y7fewk	10	21	that	that	WDT
cord-257027-q2y7fewk	10	22	will	will	MD
cord-257027-q2y7fewk	10	23	provide	provide	VB
cord-257027-q2y7fewk	10	24	a	a	DT
cord-257027-q2y7fewk	10	25	structure	structure	NN
cord-257027-q2y7fewk	10	26	to	to	IN
cord-257027-q2y7fewk	10	27	the	the	DT
cord-257027-q2y7fewk	10	28	huge	huge	JJ
cord-257027-q2y7fewk	10	29	amount	amount	NN
cord-257027-q2y7fewk	10	30	of	of	IN
cord-257027-q2y7fewk	10	31	genomic	genomic	JJ
cord-257027-q2y7fewk	10	32	data	datum	NNS
cord-257027-q2y7fewk	10	33	.	.	.
cord-257027-q2y7fewk	11	1	Braz	Braz	NNP
cord-257027-q2y7fewk	11	2	J	J	NNP
cord-257027-q2y7fewk	11	3	Med	Med	NNP
cord-257027-q2y7fewk	11	4	Biol	Biol	NNP
cord-257027-q2y7fewk	11	5	Res	Res	NNP
cord-257027-q2y7fewk	11	6	45	45	CD
cord-257027-q2y7fewk	11	7	(	(	-LRB-
cord-257027-q2y7fewk	11	8	5	5	CD
cord-257027-q2y7fewk	11	9	)	)	-RRB-
cord-257027-q2y7fewk	12	1	Infectious	infectious	JJ
cord-257027-q2y7fewk	12	2	agents	agent	NNS
cord-257027-q2y7fewk	12	3	remain	remain	VBP
cord-257027-q2y7fewk	12	4	a	a	DT
cord-257027-q2y7fewk	12	5	major	major	JJ
cord-257027-q2y7fewk	12	6	cause	cause	NN
cord-257027-q2y7fewk	12	7	of	of	IN
cord-257027-q2y7fewk	12	8	morbidity	morbidity	NN
cord-257027-q2y7fewk	12	9	and	and	CC
cord-257027-q2y7fewk	12	10	mortality	mortality	NN
cord-257027-q2y7fewk	12	11	worldwide	worldwide	RB
cord-257027-q2y7fewk	12	12	in	in	IN
cord-257027-q2y7fewk	12	13	spite	spite	NN
cord-257027-q2y7fewk	12	14	of	of	IN
cord-257027-q2y7fewk	12	15	advances	advance	NNS
cord-257027-q2y7fewk	12	16	in	in	IN
cord-257027-q2y7fewk	12	17	hygiene	hygiene	NN
cord-257027-q2y7fewk	12	18	,	,	,
cord-257027-q2y7fewk	12	19	drug	drug	NN
cord-257027-q2y7fewk	12	20	development	development	NN
cord-257027-q2y7fewk	12	21	,	,	,
cord-257027-q2y7fewk	12	22	and	and	CC
cord-257027-q2y7fewk	12	23	vaccines	vaccine	NNS
cord-257027-q2y7fewk	12	24	.	.	.
cord-257027-q2y7fewk	13	1	The	the	DT
cord-257027-q2y7fewk	13	2	emergence	emergence	NN
cord-257027-q2y7fewk	13	3	of	of	IN
cord-257027-q2y7fewk	13	4	drugresistant	drugresistant	JJ
cord-257027-q2y7fewk	13	5	strains	strain	NNS
cord-257027-q2y7fewk	13	6	of	of	IN
cord-257027-q2y7fewk	13	7	infectious	infectious	JJ
cord-257027-q2y7fewk	13	8	agents	agent	NNS
cord-257027-q2y7fewk	13	9	(	(	-LRB-
cord-257027-q2y7fewk	13	10	including	include	VBG
cord-257027-q2y7fewk	13	11	bacteria	bacteria	NNS
cord-257027-q2y7fewk	13	12	,	,	,
cord-257027-q2y7fewk	13	13	viruses	virus	NNS
cord-257027-q2y7fewk	13	14	and	and	CC
cord-257027-q2y7fewk	13	15	parasites	parasite	NNS
cord-257027-q2y7fewk	13	16	)	)	-RRB-
cord-257027-q2y7fewk	13	17	and	and	CC
cord-257027-q2y7fewk	13	18	emerging	emerge	VBG
cord-257027-q2y7fewk	13	19	diseases	disease	NNS
cord-257027-q2y7fewk	13	20	caused	cause	VBN
cord-257027-q2y7fewk	13	21	by	by	IN
cord-257027-q2y7fewk	13	22	either	either	DT
cord-257027-q2y7fewk	13	23	newly	newly	RB
cord-257027-q2y7fewk	13	24	identified	identify	VBN
cord-257027-q2y7fewk	13	25	infectious	infectious	JJ
cord-257027-q2y7fewk	13	26	agents	agent	NNS
cord-257027-q2y7fewk	13	27	or	or	CC
cord-257027-q2y7fewk	13	28	newly	newly	RB
cord-257027-q2y7fewk	13	29	identified	identify	VBN
cord-257027-q2y7fewk	13	30	pathogen	pathogen	NN
cord-257027-q2y7fewk	13	31	strains	strain	NNS
cord-257027-q2y7fewk	13	32	(	(	-LRB-
cord-257027-q2y7fewk	13	33	e.g.	e.g.	RB
cord-257027-q2y7fewk	13	34	,	,	,
cord-257027-q2y7fewk	13	35	severe	severe	JJ
cord-257027-q2y7fewk	13	36	acute	acute	JJ
cord-257027-q2y7fewk	13	37	respiratory	respiratory	JJ
cord-257027-q2y7fewk	13	38	syndrome	syndrome	NN
cord-257027-q2y7fewk	13	39	corona	corona	NN
cord-257027-q2y7fewk	13	40	virus	virus	NN
cord-257027-q2y7fewk	13	41	,	,	,
cord-257027-q2y7fewk	13	42	H5N1	H5N1	NNP
cord-257027-q2y7fewk	13	43	avian	avian	JJ
cord-257027-q2y7fewk	13	44	flu	flu	NN
cord-257027-q2y7fewk	13	45	,	,	,
cord-257027-q2y7fewk	13	46	H1N1	H1N1	NNP
cord-257027-q2y7fewk	13	47	swine	swine	NN
cord-257027-q2y7fewk	13	48	flu	flu	NN
cord-257027-q2y7fewk	13	49	)	)	-RRB-
cord-257027-q2y7fewk	13	50	are	be	VBP
cord-257027-q2y7fewk	13	51	a	a	DT
cord-257027-q2y7fewk	13	52	global	global	JJ
cord-257027-q2y7fewk	13	53	health	health	NN
cord-257027-q2y7fewk	13	54	concern	concern	NN
cord-257027-q2y7fewk	13	55	.	.	.
cord-257027-q2y7fewk	14	1	Vaccine	vaccine	NN
cord-257027-q2y7fewk	14	2	development	development	NN
cord-257027-q2y7fewk	14	3	therefore	therefore	RB
cord-257027-q2y7fewk	14	4	appears	appear	VBZ
cord-257027-q2y7fewk	14	5	to	to	TO
cord-257027-q2y7fewk	14	6	be	be	VB
cord-257027-q2y7fewk	14	7	essential	essential	JJ
cord-257027-q2y7fewk	14	8	to	to	TO
cord-257027-q2y7fewk	14	9	limit	limit	VB
cord-257027-q2y7fewk	14	10	the	the	DT
cord-257027-q2y7fewk	14	11	spread	spread	NN
cord-257027-q2y7fewk	14	12	of	of	IN
cord-257027-q2y7fewk	14	13	emergent	emergent	JJ
cord-257027-q2y7fewk	14	14	and	and	CC
cord-257027-q2y7fewk	14	15	re	re	JJ
cord-257027-q2y7fewk	14	16	-	-	JJ
cord-257027-q2y7fewk	14	17	emergent	emergent	JJ
cord-257027-q2y7fewk	14	18	diseases	disease	NNS
cord-257027-q2y7fewk	14	19	.	.	.
cord-257027-q2y7fewk	15	1	However	however	RB
cord-257027-q2y7fewk	15	2	,	,	,
cord-257027-q2y7fewk	15	3	the	the	DT
cord-257027-q2y7fewk	15	4	development	development	NN
cord-257027-q2y7fewk	15	5	of	of	IN
cord-257027-q2y7fewk	15	6	vaccines	vaccine	NNS
cord-257027-q2y7fewk	15	7	faces	face	VBZ
cord-257027-q2y7fewk	15	8	major	major	JJ
cord-257027-q2y7fewk	15	9	difficulties	difficulty	NNS
cord-257027-q2y7fewk	15	10	highlighted	highlight	VBN
cord-257027-q2y7fewk	15	11	by	by	IN
cord-257027-q2y7fewk	15	12	the	the	DT
cord-257027-q2y7fewk	15	13	absence	absence	NN
cord-257027-q2y7fewk	15	14	of	of	IN
cord-257027-q2y7fewk	15	15	efficient	efficient	JJ
cord-257027-q2y7fewk	15	16	vaccines	vaccine	NNS
cord-257027-q2y7fewk	15	17	against	against	IN
cord-257027-q2y7fewk	15	18	major	major	JJ
cord-257027-q2y7fewk	15	19	health	health	NN
cord-257027-q2y7fewk	15	20	concern	concern	NN
cord-257027-q2y7fewk	15	21	infectious	infectious	JJ
cord-257027-q2y7fewk	15	22	diseases	disease	NNS
cord-257027-q2y7fewk	15	23	,	,	,
cord-257027-q2y7fewk	15	24	such	such	JJ
cord-257027-q2y7fewk	15	25	as	as	IN
cord-257027-q2y7fewk	15	26	malaria	malaria	NN
cord-257027-q2y7fewk	15	27	,	,	,
cord-257027-q2y7fewk	15	28	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	15	29	,	,	,
cord-257027-q2y7fewk	15	30	and	and	CC
cord-257027-q2y7fewk	15	31	AIDS	AIDS	NNP
cord-257027-q2y7fewk	15	32	(	(	-LRB-
cord-257027-q2y7fewk	15	33	1	1	CD
cord-257027-q2y7fewk	15	34	)	)	-RRB-
cord-257027-q2y7fewk	15	35	.	.	.
cord-257027-q2y7fewk	16	1	The	the	DT
cord-257027-q2y7fewk	16	2	difficulties	difficulty	NNS
cord-257027-q2y7fewk	16	3	range	range	VBP
cord-257027-q2y7fewk	16	4	from	from	IN
cord-257027-q2y7fewk	16	5	i	i	NN
cord-257027-q2y7fewk	16	6	)	)	-RRB-
cord-257027-q2y7fewk	17	1	the	the	DT
cord-257027-q2y7fewk	17	2	incapacity	incapacity	NN
cord-257027-q2y7fewk	17	3	of	of	IN
cord-257027-q2y7fewk	17	4	inducing	induce	VBG
cord-257027-q2y7fewk	17	5	host	host	NN
cord-257027-q2y7fewk	17	6	protective	protective	JJ
cord-257027-q2y7fewk	17	7	responses	response	NNS
cord-257027-q2y7fewk	17	8	due	due	JJ
cord-257027-q2y7fewk	17	9	to	to	IN
cord-257027-q2y7fewk	17	10	inadequate	inadequate	JJ
cord-257027-q2y7fewk	17	11	adjuvant	adjuvant	NN
cord-257027-q2y7fewk	17	12	,	,	,
cord-257027-q2y7fewk	17	13	dose	dose	NN
cord-257027-q2y7fewk	17	14	,	,	,
cord-257027-q2y7fewk	17	15	route	route	NN
cord-257027-q2y7fewk	17	16	of	of	IN
cord-257027-q2y7fewk	17	17	immunization	immunization	NN
cord-257027-q2y7fewk	17	18	,	,	,
cord-257027-q2y7fewk	17	19	or	or	CC
cord-257027-q2y7fewk	17	20	candidate	candidate	NN
cord-257027-q2y7fewk	17	21	vaccine	vaccine	NN
cord-257027-q2y7fewk	17	22	antigens	antigen	NNS
cord-257027-q2y7fewk	17	23	with	with	IN
cord-257027-q2y7fewk	17	24	low	low	JJ
cord-257027-q2y7fewk	17	25	immunogenicity	immunogenicity	NN
cord-257027-q2y7fewk	17	26	,	,	,
cord-257027-q2y7fewk	17	27	high	high	JJ
cord-257027-q2y7fewk	17	28	rate	rate	NN
cord-257027-q2y7fewk	17	29	of	of	IN
cord-257027-q2y7fewk	17	30	genetic	genetic	JJ
cord-257027-q2y7fewk	17	31	variation	variation	NN
cord-257027-q2y7fewk	17	32	,	,	,
cord-257027-q2y7fewk	17	33	or	or	CC
cord-257027-q2y7fewk	17	34	limited	limited	JJ
cord-257027-q2y7fewk	17	35	accessibility	accessibility	NN
cord-257027-q2y7fewk	17	36	to	to	IN
cord-257027-q2y7fewk	17	37	the	the	DT
cord-257027-q2y7fewk	17	38	immune	immune	JJ
cord-257027-q2y7fewk	17	39	system	system	NN
cord-257027-q2y7fewk	17	40	,	,	,
cord-257027-q2y7fewk	17	41	to	to	IN
cord-257027-q2y7fewk	17	42	ii	ii	LS
cord-257027-q2y7fewk	17	43	)	)	-RRB-
cord-257027-q2y7fewk	17	44	high	high	JJ
cord-257027-q2y7fewk	17	45	interindividual	interindividual	JJ
cord-257027-q2y7fewk	17	46	variability	variability	NN
cord-257027-q2y7fewk	17	47	in	in	IN
cord-257027-q2y7fewk	17	48	the	the	DT
cord-257027-q2y7fewk	17	49	response	response	NN
cord-257027-q2y7fewk	17	50	to	to	IN
cord-257027-q2y7fewk	17	51	the	the	DT
cord-257027-q2y7fewk	17	52	vaccine	vaccine	NN
cord-257027-q2y7fewk	17	53	observed	observe	VBD
cord-257027-q2y7fewk	17	54	as	as	RB
cord-257027-q2y7fewk	17	55	highly	highly	RB
cord-257027-q2y7fewk	17	56	variable	variable	JJ
cord-257027-q2y7fewk	17	57	adverse	adverse	JJ
cord-257027-q2y7fewk	17	58	event	event	NN
cord-257027-q2y7fewk	17	59	risk	risk	NN
cord-257027-q2y7fewk	17	60	or	or	CC
cord-257027-q2y7fewk	17	61	protective	protective	JJ
cord-257027-q2y7fewk	17	62	efficacy	efficacy	NN
cord-257027-q2y7fewk	17	63	,	,	,
cord-257027-q2y7fewk	17	64	which	which	WDT
cord-257027-q2y7fewk	17	65	are	be	VBP
cord-257027-q2y7fewk	17	66	partially	partially	RB
cord-257027-q2y7fewk	17	67	determined	determine	VBN
cord-257027-q2y7fewk	17	68	by	by	IN
cord-257027-q2y7fewk	17	69	the	the	DT
cord-257027-q2y7fewk	17	70	genetic	genetic	JJ
cord-257027-q2y7fewk	17	71	background	background	NN
cord-257027-q2y7fewk	17	72	and	and	CC
cord-257027-q2y7fewk	17	73	the	the	DT
cord-257027-q2y7fewk	17	74	immune	immune	JJ
cord-257027-q2y7fewk	17	75	status	status	NN
cord-257027-q2y7fewk	17	76	of	of	IN
cord-257027-q2y7fewk	17	77	vaccine	vaccine	NN
cord-257027-q2y7fewk	17	78	recipients	recipient	NNS
cord-257027-q2y7fewk	17	79	.	.	.
cord-257027-q2y7fewk	18	1	New	new	JJ
cord-257027-q2y7fewk	18	2	high	high	JJ
cord-257027-q2y7fewk	18	3	-	-	HYPH
cord-257027-q2y7fewk	18	4	throughput	throughput	NN
cord-257027-q2y7fewk	18	5	technologies	technology	NNS
cord-257027-q2y7fewk	18	6	,	,	,
cord-257027-q2y7fewk	18	7	new	new	JJ
cord-257027-q2y7fewk	18	8	statistical	statistical	JJ
cord-257027-q2y7fewk	18	9	and	and	CC
cord-257027-q2y7fewk	18	10	bioinformatics	bioinformatics	NN
cord-257027-q2y7fewk	18	11	tools	tool	NNS
cord-257027-q2y7fewk	18	12	,	,	,
cord-257027-q2y7fewk	18	13	and	and	CC
cord-257027-q2y7fewk	18	14	new	new	JJ
cord-257027-q2y7fewk	18	15	biological	biological	JJ
cord-257027-q2y7fewk	18	16	concepts	concept	NNS
cord-257027-q2y7fewk	18	17	such	such	JJ
cord-257027-q2y7fewk	18	18	as	as	IN
cord-257027-q2y7fewk	18	19	molecular	molecular	JJ
cord-257027-q2y7fewk	18	20	networks	network	NNS
cord-257027-q2y7fewk	18	21	should	should	MD
cord-257027-q2y7fewk	18	22	help	help	VB
cord-257027-q2y7fewk	18	23	in	in	IN
cord-257027-q2y7fewk	18	24	overcoming	overcome	VBG
cord-257027-q2y7fewk	18	25	some	some	DT
cord-257027-q2y7fewk	18	26	of	of	IN
cord-257027-q2y7fewk	18	27	these	these	DT
cord-257027-q2y7fewk	18	28	difficulties	difficulty	NNS
cord-257027-q2y7fewk	18	29	.	.	.
cord-257027-q2y7fewk	19	1	In	in	IN
cord-257027-q2y7fewk	19	2	particular	particular	JJ
cord-257027-q2y7fewk	19	3	,	,	,
cord-257027-q2y7fewk	19	4	the	the	DT
cord-257027-q2y7fewk	19	5	availability	availability	NN
cord-257027-q2y7fewk	19	6	of	of	IN
cord-257027-q2y7fewk	19	7	complete	complete	JJ
cord-257027-q2y7fewk	19	8	microbe	microbe	NN
cord-257027-q2y7fewk	19	9	genome	genome	NN
cord-257027-q2y7fewk	19	10	sequences	sequence	NNS
cord-257027-q2y7fewk	19	11	,	,	,
cord-257027-q2y7fewk	19	12	including	include	VBG
cord-257027-q2y7fewk	19	13	the	the	DT
cord-257027-q2y7fewk	19	14	sequences	sequence	NNS
cord-257027-q2y7fewk	19	15	of	of	IN
cord-257027-q2y7fewk	19	16	multiple	multiple	JJ
cord-257027-q2y7fewk	19	17	strains	strain	NNS
cord-257027-q2y7fewk	19	18	of	of	IN
cord-257027-q2y7fewk	19	19	a	a	DT
cord-257027-q2y7fewk	19	20	pathogen	pathogen	NN
cord-257027-q2y7fewk	19	21	,	,	,
cord-257027-q2y7fewk	19	22	may	may	MD
cord-257027-q2y7fewk	19	23	help	help	VB
cord-257027-q2y7fewk	19	24	in	in	IN
cord-257027-q2y7fewk	19	25	identifying	identify	VBG
cord-257027-q2y7fewk	19	26	new	new	JJ
cord-257027-q2y7fewk	19	27	candidate	candidate	NN
cord-257027-q2y7fewk	19	28	antigens	antigen	NNS
cord-257027-q2y7fewk	19	29	(	(	-LRB-
cord-257027-q2y7fewk	19	30	2	2	CD
cord-257027-q2y7fewk	19	31	)	)	-RRB-
cord-257027-q2y7fewk	19	32	.	.	.
cord-257027-q2y7fewk	20	1	Furthermore	furthermore	RB
cord-257027-q2y7fewk	20	2	,	,	,
cord-257027-q2y7fewk	20	3	new	new	JJ
cord-257027-q2y7fewk	20	4	high	high	JJ
cord-257027-q2y7fewk	20	5	-	-	HYPH
cord-257027-q2y7fewk	20	6	throughput	throughput	NN
cord-257027-q2y7fewk	20	7	technologies	technology	NNS
cord-257027-q2y7fewk	20	8	may	may	MD
cord-257027-q2y7fewk	20	9	lead	lead	VB
cord-257027-q2y7fewk	20	10	to	to	IN
cord-257027-q2y7fewk	20	11	a	a	DT
cord-257027-q2y7fewk	20	12	better	well	JJR
cord-257027-q2y7fewk	20	13	understanding	understanding	NN
cord-257027-q2y7fewk	20	14	of	of	IN
cord-257027-q2y7fewk	20	15	genetic	genetic	JJ
cord-257027-q2y7fewk	20	16	variation	variation	NN
cord-257027-q2y7fewk	20	17	in	in	IN
cord-257027-q2y7fewk	20	18	resistance	resistance	NN
cord-257027-q2y7fewk	20	19	to	to	IN
cord-257027-q2y7fewk	20	20	infectious	infectious	JJ
cord-257027-q2y7fewk	20	21	disease	disease	NN
cord-257027-q2y7fewk	20	22	and	and	CC
cord-257027-q2y7fewk	20	23	in	in	IN
cord-257027-q2y7fewk	20	24	response	response	NN
cord-257027-q2y7fewk	20	25	to	to	IN
cord-257027-q2y7fewk	20	26	vaccination	vaccination	NN
cord-257027-q2y7fewk	20	27	.	.	.
cord-257027-q2y7fewk	21	1	Here	here	RB
cord-257027-q2y7fewk	21	2	,	,	,
cord-257027-q2y7fewk	21	3	we	-PRON-	PRP
cord-257027-q2y7fewk	21	4	will	will	MD
cord-257027-q2y7fewk	21	5	present	present	VB
cord-257027-q2y7fewk	21	6	recent	recent	JJ
cord-257027-q2y7fewk	21	7	advances	advance	NNS
cord-257027-q2y7fewk	21	8	in	in	IN
cord-257027-q2y7fewk	21	9	genomic	genomic	NN
cord-257027-q2y7fewk	21	10	-	-	HYPH
cord-257027-q2y7fewk	21	11	based	base	VBN
cord-257027-q2y7fewk	21	12	vaccine	vaccine	NN
cord-257027-q2y7fewk	21	13	approaches	approach	NNS
cord-257027-q2y7fewk	21	14	,	,	,
cord-257027-q2y7fewk	21	15	genetic	genetic	JJ
cord-257027-q2y7fewk	21	16	control	control	NN
cord-257027-q2y7fewk	21	17	in	in	IN
cord-257027-q2y7fewk	21	18	www.bjournal.com.br	www.bjournal.com.br	NNP
cord-257027-q2y7fewk	21	19	Braz	Braz	NNP
cord-257027-q2y7fewk	21	20	J	J	NNP
cord-257027-q2y7fewk	21	21	Med	Med	NNP
cord-257027-q2y7fewk	21	22	Biol	Biol	NNP
cord-257027-q2y7fewk	21	23	Res	Res	NNP
cord-257027-q2y7fewk	21	24	45	45	CD
cord-257027-q2y7fewk	21	25	(	(	-LRB-
cord-257027-q2y7fewk	21	26	5	5	CD
cord-257027-q2y7fewk	21	27	)	)	-RRB-
cord-257027-q2y7fewk	21	28	2012	2012	CD
cord-257027-q2y7fewk	21	29	infectious	infectious	JJ
cord-257027-q2y7fewk	21	30	diseases	disease	NNS
cord-257027-q2y7fewk	21	31	,	,	,
cord-257027-q2y7fewk	21	32	and	and	CC
cord-257027-q2y7fewk	21	33	we	-PRON-	PRP
cord-257027-q2y7fewk	21	34	will	will	MD
cord-257027-q2y7fewk	21	35	discuss	discuss	VB
cord-257027-q2y7fewk	21	36	the	the	DT
cord-257027-q2y7fewk	21	37	possibility	possibility	NN
cord-257027-q2y7fewk	21	38	of	of	IN
cord-257027-q2y7fewk	21	39	vaccines	vaccine	NNS
cord-257027-q2y7fewk	21	40	for	for	IN
cord-257027-q2y7fewk	21	41	target	target	NN
cord-257027-q2y7fewk	21	42	groups	group	NNS
cord-257027-q2y7fewk	21	43	or	or	CC
cord-257027-q2y7fewk	21	44	personalized	personalized	JJ
cord-257027-q2y7fewk	21	45	vaccines	vaccine	NNS
cord-257027-q2y7fewk	21	46	.	.	.
cord-257027-q2y7fewk	22	1	The	the	DT
cord-257027-q2y7fewk	22	2	first	first	JJ
cord-257027-q2y7fewk	22	3	vaccines	vaccine	NNS
cord-257027-q2y7fewk	22	4	resulted	result	VBD
cord-257027-q2y7fewk	22	5	from	from	IN
cord-257027-q2y7fewk	22	6	empirical	empirical	JJ
cord-257027-q2y7fewk	22	7	studies	study	NNS
cord-257027-q2y7fewk	22	8	and	and	CC
cord-257027-q2y7fewk	22	9	were	be	VBD
cord-257027-q2y7fewk	22	10	mainly	mainly	RB
cord-257027-q2y7fewk	22	11	composed	compose	VBN
cord-257027-q2y7fewk	22	12	of	of	IN
cord-257027-q2y7fewk	22	13	whole	whole	JJ
cord-257027-q2y7fewk	22	14	organisms	organism	NNS
cord-257027-q2y7fewk	22	15	(	(	-LRB-
cord-257027-q2y7fewk	22	16	live	live	VBP
cord-257027-q2y7fewk	22	17	attenuated	attenuated	JJ
cord-257027-q2y7fewk	22	18	or	or	CC
cord-257027-q2y7fewk	22	19	killed	kill	VBN
cord-257027-q2y7fewk	22	20	)	)	-RRB-
cord-257027-q2y7fewk	22	21	or	or	CC
cord-257027-q2y7fewk	22	22	inactivated	inactivate	VBN
cord-257027-q2y7fewk	22	23	toxins	toxin	NNS
cord-257027-q2y7fewk	22	24	.	.	.
cord-257027-q2y7fewk	23	1	The	the	DT
cord-257027-q2y7fewk	23	2	majority	majority	NN
cord-257027-q2y7fewk	23	3	of	of	IN
cord-257027-q2y7fewk	23	4	vaccine	vaccine	NN
cord-257027-q2y7fewk	23	5	studies	study	NNS
cord-257027-q2y7fewk	23	6	developed	develop	VBN
cord-257027-q2y7fewk	23	7	later	later	RB
cord-257027-q2y7fewk	23	8	also	also	RB
cord-257027-q2y7fewk	23	9	used	use	VBD
cord-257027-q2y7fewk	23	10	conventional	conventional	JJ
cord-257027-q2y7fewk	23	11	approaches	approach	NNS
cord-257027-q2y7fewk	23	12	to	to	TO
cord-257027-q2y7fewk	23	13	select	select	VB
cord-257027-q2y7fewk	23	14	for	for	IN
cord-257027-q2y7fewk	23	15	appropriate	appropriate	JJ
cord-257027-q2y7fewk	23	16	antigens	antigen	NNS
cord-257027-q2y7fewk	23	17	.	.	.
cord-257027-q2y7fewk	24	1	Antigen	antigen	NN
cord-257027-q2y7fewk	24	2	selection	selection	NN
cord-257027-q2y7fewk	24	3	was	be	VBD
cord-257027-q2y7fewk	24	4	a	a	DT
cord-257027-q2y7fewk	24	5	key	key	JJ
cord-257027-q2y7fewk	24	6	step	step	NN
cord-257027-q2y7fewk	24	7	in	in	IN
cord-257027-q2y7fewk	24	8	vaccine	vaccine	NN
cord-257027-q2y7fewk	24	9	development	development	NN
cord-257027-q2y7fewk	24	10	in	in	IN
cord-257027-q2y7fewk	24	11	the	the	DT
cord-257027-q2y7fewk	24	12	pre	pre	JJ
cord-257027-q2y7fewk	24	13	-	-	JJ
cord-257027-q2y7fewk	24	14	genomic	genomic	JJ
cord-257027-q2y7fewk	24	15	era	era	NN
cord-257027-q2y7fewk	24	16	but	but	CC
cord-257027-q2y7fewk	24	17	was	be	VBD
cord-257027-q2y7fewk	24	18	time	time	NN
cord-257027-q2y7fewk	24	19	-	-	HYPH
cord-257027-q2y7fewk	24	20	consuming	consume	VBG
cord-257027-q2y7fewk	24	21	and	and	CC
cord-257027-q2y7fewk	24	22	had	have	VBD
cord-257027-q2y7fewk	24	23	many	many	JJ
cord-257027-q2y7fewk	24	24	limitations	limitation	NNS
cord-257027-q2y7fewk	24	25	.	.	.
cord-257027-q2y7fewk	25	1	The	the	DT
cord-257027-q2y7fewk	25	2	properties	property	NNS
cord-257027-q2y7fewk	25	3	aimed	aim	VBN
cord-257027-q2y7fewk	25	4	for	for	IN
cord-257027-q2y7fewk	25	5	in	in	IN
cord-257027-q2y7fewk	25	6	these	these	DT
cord-257027-q2y7fewk	25	7	molecules	molecule	NNS
cord-257027-q2y7fewk	25	8	were	be	VBD
cord-257027-q2y7fewk	25	9	:	:	:
cord-257027-q2y7fewk	25	10	1	1	LS
cord-257027-q2y7fewk	25	11	)	)	-RRB-
cord-257027-q2y7fewk	25	12	being	be	VBG
cord-257027-q2y7fewk	25	13	accessible	accessible	JJ
cord-257027-q2y7fewk	25	14	to	to	IN
cord-257027-q2y7fewk	25	15	the	the	DT
cord-257027-q2y7fewk	25	16	immune	immune	JJ
cord-257027-q2y7fewk	25	17	system	system	NN
cord-257027-q2y7fewk	25	18	and	and	CC
cord-257027-q2y7fewk	25	19	inducing	induce	VBG
cord-257027-q2y7fewk	25	20	protective	protective	JJ
cord-257027-q2y7fewk	25	21	immunity	immunity	NN
cord-257027-q2y7fewk	25	22	and	and	CC
cord-257027-q2y7fewk	25	23	2	2	LS
cord-257027-q2y7fewk	25	24	)	)	-RRB-
cord-257027-q2y7fewk	25	25	being	be	VBG
cord-257027-q2y7fewk	25	26	conserved	conserve	VBN
cord-257027-q2y7fewk	25	27	within	within	IN
cord-257027-q2y7fewk	25	28	the	the	DT
cord-257027-q2y7fewk	25	29	species	specie	NNS
cord-257027-q2y7fewk	25	30	and	and	CC
cord-257027-q2y7fewk	25	31	not	not	RB
cord-257027-q2y7fewk	25	32	containing	contain	VBG
cord-257027-q2y7fewk	25	33	regions	region	NNS
cord-257027-q2y7fewk	25	34	of	of	IN
cord-257027-q2y7fewk	25	35	high	high	JJ
cord-257027-q2y7fewk	25	36	variability	variability	NN
cord-257027-q2y7fewk	25	37	(	(	-LRB-
cord-257027-q2y7fewk	25	38	3	3	CD
cord-257027-q2y7fewk	25	39	)	)	-RRB-
cord-257027-q2y7fewk	25	40	.	.	.
cord-257027-q2y7fewk	26	1	The	the	DT
cord-257027-q2y7fewk	26	2	selection	selection	NN
cord-257027-q2y7fewk	26	3	of	of	IN
cord-257027-q2y7fewk	26	4	good	good	JJ
cord-257027-q2y7fewk	26	5	candidate	candidate	NN
cord-257027-q2y7fewk	26	6	vaccine	vaccine	NN
cord-257027-q2y7fewk	26	7	antigens	antigen	NNS
cord-257027-q2y7fewk	26	8	was	be	VBD
cord-257027-q2y7fewk	26	9	primarily	primarily	RB
cord-257027-q2y7fewk	26	10	based	base	VBN
cord-257027-q2y7fewk	26	11	on	on	IN
cord-257027-q2y7fewk	26	12	the	the	DT
cord-257027-q2y7fewk	26	13	capacity	capacity	NN
cord-257027-q2y7fewk	26	14	of	of	IN
cord-257027-q2y7fewk	26	15	induction	induction	NN
cord-257027-q2y7fewk	26	16	of	of	IN
cord-257027-q2y7fewk	26	17	protective	protective	JJ
cord-257027-q2y7fewk	26	18	antibodies	antibody	NNS
cord-257027-q2y7fewk	26	19	,	,	,
cord-257027-q2y7fewk	26	20	which	which	WDT
cord-257027-q2y7fewk	26	21	probably	probably	RB
cord-257027-q2y7fewk	26	22	explains	explain	VBZ
cord-257027-q2y7fewk	26	23	why	why	WRB
cord-257027-q2y7fewk	26	24	effective	effective	JJ
cord-257027-q2y7fewk	26	25	vaccines	vaccine	NNS
cord-257027-q2y7fewk	26	26	currently	currently	RB
cord-257027-q2y7fewk	26	27	available	available	JJ
cord-257027-q2y7fewk	26	28	mainly	mainly	RB
cord-257027-q2y7fewk	26	29	induce	induce	VBP
cord-257027-q2y7fewk	26	30	a	a	DT
cord-257027-q2y7fewk	26	31	protective	protective	JJ
cord-257027-q2y7fewk	26	32	humoral	humoral	JJ
cord-257027-q2y7fewk	26	33	immune	immune	JJ
cord-257027-q2y7fewk	26	34	response	response	NN
cord-257027-q2y7fewk	26	35	(	(	-LRB-
cord-257027-q2y7fewk	26	36	1	1	CD
cord-257027-q2y7fewk	26	37	)	)	-RRB-
cord-257027-q2y7fewk	26	38	.	.	.
cord-257027-q2y7fewk	27	1	More	more	RBR
cord-257027-q2y7fewk	27	2	recently	recently	RB
cord-257027-q2y7fewk	27	3	,	,	,
cord-257027-q2y7fewk	27	4	molecular	molecular	JJ
cord-257027-q2y7fewk	27	5	biology	biology	NN
cord-257027-q2y7fewk	27	6	methods	method	NNS
cord-257027-q2y7fewk	27	7	have	have	VBP
cord-257027-q2y7fewk	27	8	been	be	VBN
cord-257027-q2y7fewk	27	9	applied	apply	VBN
cord-257027-q2y7fewk	27	10	to	to	IN
cord-257027-q2y7fewk	27	11	the	the	DT
cord-257027-q2y7fewk	27	12	development	development	NN
cord-257027-q2y7fewk	27	13	of	of	IN
cord-257027-q2y7fewk	27	14	new	new	JJ
cord-257027-q2y7fewk	27	15	vaccines	vaccine	NNS
cord-257027-q2y7fewk	27	16	,	,	,
cord-257027-q2y7fewk	27	17	primarily	primarily	RB
cord-257027-q2y7fewk	27	18	to	to	TO
cord-257027-q2y7fewk	27	19	enable	enable	VB
cord-257027-q2y7fewk	27	20	large	large	JJ
cord-257027-q2y7fewk	27	21	-	-	HYPH
cord-257027-q2y7fewk	27	22	scale	scale	NN
cord-257027-q2y7fewk	27	23	production	production	NN
cord-257027-q2y7fewk	27	24	of	of	IN
cord-257027-q2y7fewk	27	25	subunit	subunit	NN
cord-257027-q2y7fewk	27	26	or	or	CC
cord-257027-q2y7fewk	27	27	peptide	peptide	NN
cord-257027-q2y7fewk	27	28	-	-	HYPH
cord-257027-q2y7fewk	27	29	based	base	VBN
cord-257027-q2y7fewk	27	30	vaccine	vaccine	NN
cord-257027-q2y7fewk	27	31	antigens	antigen	NNS
cord-257027-q2y7fewk	27	32	.	.	.
cord-257027-q2y7fewk	28	1	Nevertheless	nevertheless	RB
cord-257027-q2y7fewk	28	2	,	,	,
cord-257027-q2y7fewk	28	3	only	only	RB
cord-257027-q2y7fewk	28	4	a	a	DT
cord-257027-q2y7fewk	28	5	small	small	JJ
cord-257027-q2y7fewk	28	6	number	number	NN
cord-257027-q2y7fewk	28	7	of	of	IN
cord-257027-q2y7fewk	28	8	available	available	JJ
cord-257027-q2y7fewk	28	9	vaccines	vaccine	NNS
cord-257027-q2y7fewk	28	10	are	be	VBP
cord-257027-q2y7fewk	28	11	based	base	VBN
cord-257027-q2y7fewk	28	12	on	on	IN
cord-257027-q2y7fewk	28	13	recombinant	recombinant	JJ
cord-257027-q2y7fewk	28	14	antigens	antigen	NNS
cord-257027-q2y7fewk	28	15	.	.	.
cord-257027-q2y7fewk	29	1	The	the	DT
cord-257027-q2y7fewk	29	2	strategies	strategy	NNS
cord-257027-q2y7fewk	29	3	of	of	IN
cord-257027-q2y7fewk	29	4	conventional	conventional	JJ
cord-257027-q2y7fewk	29	5	vaccinology	vaccinology	NN
cord-257027-q2y7fewk	29	6	pose	pose	VBP
cord-257027-q2y7fewk	29	7	limitations	limitation	NNS
cord-257027-q2y7fewk	29	8	for	for	IN
cord-257027-q2y7fewk	29	9	the	the	DT
cord-257027-q2y7fewk	29	10	development	development	NN
cord-257027-q2y7fewk	29	11	of	of	IN
cord-257027-q2y7fewk	29	12	effective	effective	JJ
cord-257027-q2y7fewk	29	13	vaccines	vaccine	NNS
cord-257027-q2y7fewk	29	14	against	against	IN
cord-257027-q2y7fewk	29	15	a	a	DT
cord-257027-q2y7fewk	29	16	variety	variety	NN
cord-257027-q2y7fewk	29	17	of	of	IN
cord-257027-q2y7fewk	29	18	infectious	infectious	JJ
cord-257027-q2y7fewk	29	19	diseases	disease	NNS
cord-257027-q2y7fewk	29	20	.	.	.
cord-257027-q2y7fewk	30	1	The	the	DT
cord-257027-q2y7fewk	30	2	development	development	NN
cord-257027-q2y7fewk	30	3	of	of	IN
cord-257027-q2y7fewk	30	4	vaccines	vaccine	NNS
cord-257027-q2y7fewk	30	5	against	against	IN
cord-257027-q2y7fewk	30	6	pathogens	pathogen	NNS
cord-257027-q2y7fewk	30	7	that	that	WDT
cord-257027-q2y7fewk	30	8	show	show	VBP
cord-257027-q2y7fewk	30	9	important	important	JJ
cord-257027-q2y7fewk	30	10	antigenic	antigenic	JJ
cord-257027-q2y7fewk	30	11	variation	variation	NN
cord-257027-q2y7fewk	30	12	or	or	CC
cord-257027-q2y7fewk	30	13	that	that	DT
cord-257027-q2y7fewk	30	14	can	can	MD
cord-257027-q2y7fewk	30	15	not	not	RB
cord-257027-q2y7fewk	30	16	be	be	VB
cord-257027-q2y7fewk	30	17	cultivated	cultivate	VBN
cord-257027-q2y7fewk	30	18	in	in	IN
cord-257027-q2y7fewk	30	19	the	the	DT
cord-257027-q2y7fewk	30	20	laboratory	laboratory	NN
cord-257027-q2y7fewk	30	21	remains	remain	VBZ
cord-257027-q2y7fewk	30	22	a	a	DT
cord-257027-q2y7fewk	30	23	great	great	JJ
cord-257027-q2y7fewk	30	24	challenge	challenge	NN
cord-257027-q2y7fewk	30	25	.	.	.
cord-257027-q2y7fewk	31	1	Currently	currently	RB
cord-257027-q2y7fewk	31	2	,	,	,
cord-257027-q2y7fewk	31	3	new	new	JJ
cord-257027-q2y7fewk	31	4	approaches	approach	NNS
cord-257027-q2y7fewk	31	5	using	use	VBG
cord-257027-q2y7fewk	31	6	high	high	JJ
cord-257027-q2y7fewk	31	7	-	-	HYPH
cord-257027-q2y7fewk	31	8	throughput	throughput	NN
cord-257027-q2y7fewk	31	9	technologies	technology	NNS
cord-257027-q2y7fewk	31	10	are	be	VBP
cord-257027-q2y7fewk	31	11	being	be	VBG
cord-257027-q2y7fewk	31	12	used	use	VBN
cord-257027-q2y7fewk	31	13	for	for	IN
cord-257027-q2y7fewk	31	14	the	the	DT
cord-257027-q2y7fewk	31	15	identification	identification	NN
cord-257027-q2y7fewk	31	16	of	of	IN
cord-257027-q2y7fewk	31	17	new	new	JJ
cord-257027-q2y7fewk	31	18	vaccine	vaccine	NN
cord-257027-q2y7fewk	31	19	candidate	candidate	NN
cord-257027-q2y7fewk	31	20	molecules	molecule	NNS
cord-257027-q2y7fewk	31	21	(	(	-LRB-
cord-257027-q2y7fewk	31	22	4	4	CD
cord-257027-q2y7fewk	31	23	)	)	-RRB-
cord-257027-q2y7fewk	31	24	.	.	.
cord-257027-q2y7fewk	32	1	The	the	DT
cord-257027-q2y7fewk	32	2	publication	publication	NN
cord-257027-q2y7fewk	32	3	of	of	IN
cord-257027-q2y7fewk	32	4	the	the	DT
cord-257027-q2y7fewk	32	5	Haemophilus	Haemophilus	NNP
cord-257027-q2y7fewk	32	6	influenzae	influenzae	NN
cord-257027-q2y7fewk	32	7	genome	genome	NN
cord-257027-q2y7fewk	32	8	,	,	,
cord-257027-q2y7fewk	32	9	the	the	DT
cord-257027-q2y7fewk	32	10	first	first	JJ
cord-257027-q2y7fewk	32	11	pathogen	pathogen	NN
cord-257027-q2y7fewk	32	12	to	to	TO
cord-257027-q2y7fewk	32	13	have	have	VB
cord-257027-q2y7fewk	32	14	its	-PRON-	PRP$
cord-257027-q2y7fewk	32	15	complete	complete	JJ
cord-257027-q2y7fewk	32	16	genome	genome	NN
cord-257027-q2y7fewk	32	17	sequence	sequence	NN
cord-257027-q2y7fewk	32	18	published	publish	VBN
cord-257027-q2y7fewk	32	19	as	as	IN
cord-257027-q2y7fewk	32	20	a	a	DT
cord-257027-q2y7fewk	32	21	result	result	NN
cord-257027-q2y7fewk	32	22	of	of	IN
cord-257027-q2y7fewk	32	23	an	an	DT
cord-257027-q2y7fewk	32	24	approach	approach	NN
cord-257027-q2y7fewk	32	25	to	to	TO
cord-257027-q2y7fewk	32	26	genome	genome	VB
cord-257027-q2y7fewk	32	27	analysis	analysis	NN
cord-257027-q2y7fewk	32	28	using	use	VBG
cord-257027-q2y7fewk	32	29	new	new	JJ
cord-257027-q2y7fewk	32	30	technologies	technology	NNS
cord-257027-q2y7fewk	32	31	of	of	IN
cord-257027-q2y7fewk	32	32	high	high	JJ
cord-257027-q2y7fewk	32	33	-	-	HYPH
cord-257027-q2y7fewk	32	34	throughput	throughput	NN
cord-257027-q2y7fewk	32	35	sequencing	sequencing	NN
cord-257027-q2y7fewk	32	36	(	(	-LRB-
cord-257027-q2y7fewk	32	37	5	5	CD
cord-257027-q2y7fewk	32	38	)	)	-RRB-
cord-257027-q2y7fewk	32	39	,	,	,
cord-257027-q2y7fewk	32	40	has	have	VBZ
cord-257027-q2y7fewk	32	41	opened	open	VBN
cord-257027-q2y7fewk	32	42	the	the	DT
cord-257027-q2y7fewk	32	43	mind	mind	NN
cord-257027-q2y7fewk	32	44	of	of	IN
cord-257027-q2y7fewk	32	45	scientists	scientist	NNS
cord-257027-q2y7fewk	32	46	to	to	IN
cord-257027-q2y7fewk	32	47	a	a	DT
cord-257027-q2y7fewk	32	48	range	range	NN
cord-257027-q2y7fewk	32	49	of	of	IN
cord-257027-q2y7fewk	32	50	new	new	JJ
cord-257027-q2y7fewk	32	51	possible	possible	JJ
cord-257027-q2y7fewk	32	52	approaches	approach	NNS
cord-257027-q2y7fewk	32	53	to	to	IN
cord-257027-q2y7fewk	32	54	the	the	DT
cord-257027-q2y7fewk	32	55	study	study	NN
cord-257027-q2y7fewk	32	56	of	of	IN
cord-257027-q2y7fewk	32	57	microorganisms	microorganism	NNS
cord-257027-q2y7fewk	32	58	and	and	CC
cord-257027-q2y7fewk	32	59	has	have	VBZ
cord-257027-q2y7fewk	32	60	marked	mark	VBN
cord-257027-q2y7fewk	32	61	the	the	DT
cord-257027-q2y7fewk	32	62	beginning	beginning	NN
cord-257027-q2y7fewk	32	63	of	of	IN
cord-257027-q2y7fewk	32	64	a	a	DT
cord-257027-q2y7fewk	32	65	new	new	JJ
cord-257027-q2y7fewk	32	66	era	era	NN
cord-257027-q2y7fewk	32	67	in	in	IN
cord-257027-q2y7fewk	32	68	vaccine	vaccine	NN
cord-257027-q2y7fewk	32	69	development	development	NN
cord-257027-q2y7fewk	32	70	:	:	:
cord-257027-q2y7fewk	32	71	the	the	DT
cord-257027-q2y7fewk	32	72	identification	identification	NN
cord-257027-q2y7fewk	32	73	of	of	IN
cord-257027-q2y7fewk	32	74	pathogen	pathogen	NN
cord-257027-q2y7fewk	32	75	candidate	candidate	NN
cord-257027-q2y7fewk	32	76	antigens	antigen	NNS
cord-257027-q2y7fewk	32	77	based	base	VBN
cord-257027-q2y7fewk	32	78	on	on	IN
cord-257027-q2y7fewk	32	79	the	the	DT
cord-257027-q2y7fewk	32	80	knowledge	knowledge	NN
cord-257027-q2y7fewk	32	81	of	of	IN
cord-257027-q2y7fewk	32	82	the	the	DT
cord-257027-q2y7fewk	32	83	genome	genome	NN
cord-257027-q2y7fewk	32	84	of	of	IN
cord-257027-q2y7fewk	32	85	the	the	DT
cord-257027-q2y7fewk	32	86	pathogen	pathogen	NN
cord-257027-q2y7fewk	32	87	and	and	CC
cord-257027-q2y7fewk	32	88	on	on	IN
cord-257027-q2y7fewk	32	89	the	the	DT
cord-257027-q2y7fewk	32	90	understanding	understanding	NN
cord-257027-q2y7fewk	32	91	of	of	IN
cord-257027-q2y7fewk	32	92	microbial	microbial	JJ
cord-257027-q2y7fewk	32	93	biology	biology	NN
cord-257027-q2y7fewk	32	94	and	and	CC
cord-257027-q2y7fewk	32	95	host	host	NN
cord-257027-q2y7fewk	32	96	-	-	HYPH
cord-257027-q2y7fewk	32	97	pathogen	pathogen	NN
cord-257027-q2y7fewk	32	98	interactions	interaction	NNS
cord-257027-q2y7fewk	32	99	,	,	,
cord-257027-q2y7fewk	32	100	an	an	DT
cord-257027-q2y7fewk	32	101	approach	approach	NN
cord-257027-q2y7fewk	32	102	called	call	VBN
cord-257027-q2y7fewk	32	103	reverse	reverse	NNP
cord-257027-q2y7fewk	32	104	vaccinology	vaccinology	NN
cord-257027-q2y7fewk	32	105	(	(	-LRB-
cord-257027-q2y7fewk	32	106	6	6	CD
cord-257027-q2y7fewk	32	107	)	)	-RRB-
cord-257027-q2y7fewk	32	108	.	.	.
cord-257027-q2y7fewk	33	1	This	this	DT
cord-257027-q2y7fewk	33	2	approach	approach	NN
cord-257027-q2y7fewk	33	3	has	have	VBZ
cord-257027-q2y7fewk	33	4	been	be	VBN
cord-257027-q2y7fewk	33	5	favored	favor	VBN
cord-257027-q2y7fewk	33	6	in	in	IN
cord-257027-q2y7fewk	33	7	recent	recent	JJ
cord-257027-q2y7fewk	33	8	years	year	NNS
cord-257027-q2y7fewk	33	9	by	by	IN
cord-257027-q2y7fewk	33	10	the	the	DT
cord-257027-q2y7fewk	33	11	use	use	NN
cord-257027-q2y7fewk	33	12	of	of	IN
cord-257027-q2y7fewk	33	13	high	high	JJ
cord-257027-q2y7fewk	33	14	-	-	HYPH
cord-257027-q2y7fewk	33	15	throughput	throughput	NN
cord-257027-q2y7fewk	33	16	technologies	technology	NNS
cord-257027-q2y7fewk	33	17	in	in	IN
cord-257027-q2y7fewk	33	18	the	the	DT
cord-257027-q2y7fewk	33	19	fields	field	NNS
cord-257027-q2y7fewk	33	20	of	of	IN
cord-257027-q2y7fewk	33	21	genomics	genomic	NNS
cord-257027-q2y7fewk	33	22	,	,	,
cord-257027-q2y7fewk	33	23	proteomics	proteomic	NNS
cord-257027-q2y7fewk	33	24	and	and	CC
cord-257027-q2y7fewk	33	25	immunomics	immunomic	NNS
cord-257027-q2y7fewk	33	26	,	,	,
cord-257027-q2y7fewk	33	27	among	among	IN
cord-257027-q2y7fewk	33	28	other	other	JJ
cord-257027-q2y7fewk	33	29	"	"	``
cord-257027-q2y7fewk	33	30	omics	omic	NNS
cord-257027-q2y7fewk	33	31	"	"	''
cord-257027-q2y7fewk	33	32	,	,	,
cord-257027-q2y7fewk	33	33	which	which	WDT
cord-257027-q2y7fewk	33	34	has	have	VBZ
cord-257027-q2y7fewk	33	35	expanded	expand	VBN
cord-257027-q2y7fewk	33	36	enormously	enormously	RB
cord-257027-q2y7fewk	33	37	.	.	.
cord-257027-q2y7fewk	34	1	The	the	DT
cord-257027-q2y7fewk	34	2	number	number	NN
cord-257027-q2y7fewk	34	3	of	of	IN
cord-257027-q2y7fewk	34	4	available	available	JJ
cord-257027-q2y7fewk	34	5	viral	viral	JJ
cord-257027-q2y7fewk	34	6	and	and	CC
cord-257027-q2y7fewk	34	7	parasitic	parasitic	JJ
cord-257027-q2y7fewk	34	8	genome	genome	NN
cord-257027-q2y7fewk	34	9	sequences	sequence	NNS
cord-257027-q2y7fewk	34	10	is	be	VBZ
cord-257027-q2y7fewk	34	11	growing	grow	VBG
cord-257027-q2y7fewk	34	12	continuously	continuously	RB
cord-257027-q2y7fewk	34	13	(	(	-LRB-
cord-257027-q2y7fewk	34	14	2	2	CD
cord-257027-q2y7fewk	34	15	)	)	-RRB-
cord-257027-q2y7fewk	34	16	,	,	,
cord-257027-q2y7fewk	34	17	and	and	CC
cord-257027-q2y7fewk	34	18	important	important	JJ
cord-257027-q2y7fewk	34	19	advances	advance	NNS
cord-257027-q2y7fewk	34	20	have	have	VBP
cord-257027-q2y7fewk	34	21	been	be	VBN
cord-257027-q2y7fewk	34	22	made	make	VBN
cord-257027-q2y7fewk	34	23	to	to	TO
cord-257027-q2y7fewk	34	24	make	make	VB
cord-257027-q2y7fewk	34	25	new	new	JJ
cord-257027-q2y7fewk	34	26	biostatistics	biostatistic	NNS
cord-257027-q2y7fewk	34	27	and	and	CC
cord-257027-q2y7fewk	34	28	bioinformatics	bioinformatics	NN
cord-257027-q2y7fewk	34	29	tools	tool	NNS
cord-257027-q2y7fewk	34	30	available	available	JJ
cord-257027-q2y7fewk	34	31	for	for	IN
cord-257027-q2y7fewk	34	32	candidate	candidate	NN
cord-257027-q2y7fewk	34	33	gene	gene	NN
cord-257027-q2y7fewk	34	34	prospection	prospection	NNP
cord-257027-q2y7fewk	34	35	.	.	.
cord-257027-q2y7fewk	35	1	The	the	DT
cord-257027-q2y7fewk	35	2	current	current	JJ
cord-257027-q2y7fewk	35	3	"	"	``
cord-257027-q2y7fewk	35	4	genomic	genomic	JJ
cord-257027-q2y7fewk	35	5	era	era	NN
cord-257027-q2y7fewk	35	6	"	"	''
cord-257027-q2y7fewk	35	7	is	be	VBZ
cord-257027-q2y7fewk	35	8	marked	mark	VBN
cord-257027-q2y7fewk	35	9	by	by	IN
cord-257027-q2y7fewk	35	10	a	a	DT
cord-257027-q2y7fewk	35	11	major	major	JJ
cord-257027-q2y7fewk	35	12	impact	impact	NN
cord-257027-q2y7fewk	35	13	on	on	IN
cord-257027-q2y7fewk	35	14	the	the	DT
cord-257027-q2y7fewk	35	15	ability	ability	NN
cord-257027-q2y7fewk	35	16	to	to	TO
cord-257027-q2y7fewk	35	17	find	find	VB
cord-257027-q2y7fewk	35	18	new	new	JJ
cord-257027-q2y7fewk	35	19	candidate	candidate	NN
cord-257027-q2y7fewk	35	20	vaccine	vaccine	NN
cord-257027-q2y7fewk	35	21	antigens	antigen	NNS
cord-257027-q2y7fewk	35	22	and	and	CC
cord-257027-q2y7fewk	35	23	to	to	TO
cord-257027-q2y7fewk	35	24	develop	develop	VB
cord-257027-q2y7fewk	35	25	effective	effective	JJ
cord-257027-q2y7fewk	35	26	vaccines	vaccine	NNS
cord-257027-q2y7fewk	35	27	.	.	.
cord-257027-q2y7fewk	36	1	One	one	CD
cord-257027-q2y7fewk	36	2	of	of	IN
cord-257027-q2y7fewk	36	3	the	the	DT
cord-257027-q2y7fewk	36	4	approaches	approach	NNS
cord-257027-q2y7fewk	36	5	that	that	WDT
cord-257027-q2y7fewk	36	6	may	may	MD
cord-257027-q2y7fewk	36	7	be	be	VB
cord-257027-q2y7fewk	36	8	used	use	VBN
cord-257027-q2y7fewk	36	9	to	to	TO
cord-257027-q2y7fewk	36	10	analyze	analyze	VB
cord-257027-q2y7fewk	36	11	the	the	DT
cord-257027-q2y7fewk	36	12	DNA	dna	NN
cord-257027-q2y7fewk	36	13	data	data	NN
cord-257027-q2y7fewk	36	14	sequences	sequence	NNS
cord-257027-q2y7fewk	36	15	in	in	IN
cord-257027-q2y7fewk	36	16	order	order	NN
cord-257027-q2y7fewk	36	17	to	to	TO
cord-257027-q2y7fewk	36	18	identify	identify	VB
cord-257027-q2y7fewk	36	19	vaccine	vaccine	NN
cord-257027-q2y7fewk	36	20	candidate	candidate	NN
cord-257027-q2y7fewk	36	21	molecules	molecule	NNS
cord-257027-q2y7fewk	36	22	is	be	VBZ
cord-257027-q2y7fewk	36	23	the	the	DT
cord-257027-q2y7fewk	36	24	in	in	IN
cord-257027-q2y7fewk	36	25	silico	silico	NN
cord-257027-q2y7fewk	36	26	analysis	analysis	NN
cord-257027-q2y7fewk	36	27	of	of	IN
cord-257027-q2y7fewk	36	28	complete	complete	JJ
cord-257027-q2y7fewk	36	29	genomes	genome	NNS
cord-257027-q2y7fewk	36	30	.	.	.
cord-257027-q2y7fewk	37	1	It	-PRON-	PRP
cord-257027-q2y7fewk	37	2	does	do	VBZ
cord-257027-q2y7fewk	37	3	not	not	RB
cord-257027-q2y7fewk	37	4	require	require	VB
cord-257027-q2y7fewk	37	5	cultivation	cultivation	NN
cord-257027-q2y7fewk	37	6	of	of	IN
cord-257027-q2y7fewk	37	7	the	the	DT
cord-257027-q2y7fewk	37	8	pathogen	pathogen	NN
cord-257027-q2y7fewk	37	9	and	and	CC
cord-257027-q2y7fewk	37	10	it	-PRON-	PRP
cord-257027-q2y7fewk	37	11	uses	use	VBZ
cord-257027-q2y7fewk	37	12	a	a	DT
cord-257027-q2y7fewk	37	13	variety	variety	NN
cord-257027-q2y7fewk	37	14	of	of	IN
cord-257027-q2y7fewk	37	15	computer	computer	NN
cord-257027-q2y7fewk	37	16	resources	resource	NNS
cord-257027-q2y7fewk	37	17	to	to	TO
cord-257027-q2y7fewk	37	18	process	process	VB
cord-257027-q2y7fewk	37	19	DNA	dna	NN
cord-257027-q2y7fewk	37	20	sequence	sequence	NN
cord-257027-q2y7fewk	37	21	data	datum	NNS
cord-257027-q2y7fewk	37	22	and	and	CC
cord-257027-q2y7fewk	37	23	the	the	DT
cord-257027-q2y7fewk	37	24	available	available	JJ
cord-257027-q2y7fewk	37	25	information	information	NN
cord-257027-q2y7fewk	37	26	about	about	IN
cord-257027-q2y7fewk	37	27	protein	protein	NN
cord-257027-q2y7fewk	37	28	functions	function	NNS
cord-257027-q2y7fewk	37	29	,	,	,
cord-257027-q2y7fewk	37	30	cell	cell	NN
cord-257027-q2y7fewk	37	31	transport	transport	NN
cord-257027-q2y7fewk	37	32	and	and	CC
cord-257027-q2y7fewk	37	33	localization	localization	NN
cord-257027-q2y7fewk	37	34	,	,	,
cord-257027-q2y7fewk	37	35	antigen	antigen	NN
cord-257027-q2y7fewk	37	36	processing	processing	NN
cord-257027-q2y7fewk	37	37	,	,	,
cord-257027-q2y7fewk	37	38	and	and	CC
cord-257027-q2y7fewk	37	39	immunogenicity	immunogenicity	NN
cord-257027-q2y7fewk	37	40	.	.	.
cord-257027-q2y7fewk	38	1	Computational	computational	JJ
cord-257027-q2y7fewk	38	2	analysis	analysis	NN
cord-257027-q2y7fewk	38	3	may	may	MD
cord-257027-q2y7fewk	38	4	then	then	RB
cord-257027-q2y7fewk	38	5	enable	enable	VB
cord-257027-q2y7fewk	38	6	the	the	DT
cord-257027-q2y7fewk	38	7	identification	identification	NN
cord-257027-q2y7fewk	38	8	of	of	IN
cord-257027-q2y7fewk	38	9	which	which	WDT
cord-257027-q2y7fewk	38	10	DNA	dna	NN
cord-257027-q2y7fewk	38	11	sequences	sequence	NNS
cord-257027-q2y7fewk	38	12	encode	encode	VBP
cord-257027-q2y7fewk	38	13	the	the	DT
cord-257027-q2y7fewk	38	14	proteins	protein	NNS
cord-257027-q2y7fewk	38	15	that	that	WDT
cord-257027-q2y7fewk	38	16	have	have	VBP
cord-257027-q2y7fewk	38	17	some	some	DT
cord-257027-q2y7fewk	38	18	relevant	relevant	JJ
cord-257027-q2y7fewk	38	19	features	feature	NNS
cord-257027-q2y7fewk	38	20	of	of	IN
cord-257027-q2y7fewk	38	21	potential	potential	JJ
cord-257027-q2y7fewk	38	22	vaccine	vaccine	NN
cord-257027-q2y7fewk	38	23	targets	target	NNS
cord-257027-q2y7fewk	38	24	(	(	-LRB-
cord-257027-q2y7fewk	38	25	7	7	CD
cord-257027-q2y7fewk	38	26	)	)	-RRB-
cord-257027-q2y7fewk	38	27	.	.	.
cord-257027-q2y7fewk	39	1	The	the	DT
cord-257027-q2y7fewk	39	2	impact	impact	NN
cord-257027-q2y7fewk	39	3	of	of	IN
cord-257027-q2y7fewk	39	4	in	in	IN
cord-257027-q2y7fewk	39	5	silico	silico	NN
cord-257027-q2y7fewk	39	6	analysis	analysis	NN
cord-257027-q2y7fewk	39	7	on	on	IN
cord-257027-q2y7fewk	39	8	vaccine	vaccine	NN
cord-257027-q2y7fewk	39	9	development	development	NN
cord-257027-q2y7fewk	39	10	can	can	MD
cord-257027-q2y7fewk	39	11	be	be	VB
cord-257027-q2y7fewk	39	12	exemplified	exemplify	VBN
cord-257027-q2y7fewk	39	13	by	by	IN
cord-257027-q2y7fewk	39	14	the	the	DT
cord-257027-q2y7fewk	39	15	first	first	JJ
cord-257027-q2y7fewk	39	16	study	study	NN
cord-257027-q2y7fewk	39	17	published	publish	VBN
cord-257027-q2y7fewk	39	18	using	use	VBG
cord-257027-q2y7fewk	39	19	this	this	DT
cord-257027-q2y7fewk	39	20	approach	approach	NN
cord-257027-q2y7fewk	39	21	(	(	-LRB-
cord-257027-q2y7fewk	39	22	8)	8)	NN
cord-257027-q2y7fewk	39	23	.	.	.
cord-257027-q2y7fewk	40	1	A	a	DT
cord-257027-q2y7fewk	40	2	capsular	capsular	JJ
cord-257027-q2y7fewk	40	3	polysaccharide	polysaccharide	NN
cord-257027-q2y7fewk	40	4	-	-	HYPH
cord-257027-q2y7fewk	40	5	based	base	VBN
cord-257027-q2y7fewk	40	6	vaccine	vaccine	NN
cord-257027-q2y7fewk	40	7	against	against	IN
cord-257027-q2y7fewk	40	8	Neisseria	Neisseria	NNP
cord-257027-q2y7fewk	40	9	meningitidis	meningitidis	NNP
cord-257027-q2y7fewk	40	10	serogroups	serogroups	NNP
cord-257027-q2y7fewk	40	11	A	A	NNP
cord-257027-q2y7fewk	40	12	,	,	,
cord-257027-q2y7fewk	40	13	C	C	NNP
cord-257027-q2y7fewk	40	14	,	,	,
cord-257027-q2y7fewk	40	15	W135	W135	NNPS
cord-257027-q2y7fewk	40	16	,	,	,
cord-257027-q2y7fewk	40	17	and	and	CC
cord-257027-q2y7fewk	40	18	Y	Y	NNP
cord-257027-q2y7fewk	40	19	is	be	VBZ
cord-257027-q2y7fewk	40	20	available	available	JJ
cord-257027-q2y7fewk	40	21	,	,	,
cord-257027-q2y7fewk	40	22	but	but	CC
cord-257027-q2y7fewk	40	23	not	not	RB
cord-257027-q2y7fewk	40	24	against	against	IN
cord-257027-q2y7fewk	40	25	serogroup	serogroup	NNP
cord-257027-q2y7fewk	40	26	B	B	NNP
cord-257027-q2y7fewk	40	27	as	as	IN
cord-257027-q2y7fewk	40	28	its	-PRON-	PRP$
cord-257027-q2y7fewk	40	29	structure	structure	NN
cord-257027-q2y7fewk	40	30	is	be	VBZ
cord-257027-q2y7fewk	40	31	identical	identical	JJ
cord-257027-q2y7fewk	40	32	to	to	IN
cord-257027-q2y7fewk	40	33	the	the	DT
cord-257027-q2y7fewk	40	34	polysialic	polysialic	JJ
cord-257027-q2y7fewk	40	35	acid	acid	NN
cord-257027-q2y7fewk	40	36	structure	structure	NN
cord-257027-q2y7fewk	40	37	present	present	JJ
cord-257027-q2y7fewk	40	38	on	on	IN
cord-257027-q2y7fewk	40	39	human	human	JJ
cord-257027-q2y7fewk	40	40	cells	cell	NNS
cord-257027-q2y7fewk	40	41	(	(	-LRB-
cord-257027-q2y7fewk	40	42	3	3	CD
cord-257027-q2y7fewk	40	43	)	)	-RRB-
cord-257027-q2y7fewk	40	44	.	.	.
cord-257027-q2y7fewk	41	1	The	the	DT
cord-257027-q2y7fewk	41	2	entire	entire	JJ
cord-257027-q2y7fewk	41	3	genome	genome	NN
cord-257027-q2y7fewk	41	4	sequence	sequence	NN
cord-257027-q2y7fewk	41	5	of	of	IN
cord-257027-q2y7fewk	41	6	a	a	DT
cord-257027-q2y7fewk	41	7	virulent	virulent	JJ
cord-257027-q2y7fewk	41	8	N.	n.	NN
cord-257027-q2y7fewk	41	9	meningitidis	meningitidis	NN
cord-257027-q2y7fewk	41	10	serogroup	serogroup	NNP
cord-257027-q2y7fewk	41	11	B	B	NNP
cord-257027-q2y7fewk	41	12	strain	strain	NN
cord-257027-q2y7fewk	41	13	,	,	,
cord-257027-q2y7fewk	41	14	which	which	WDT
cord-257027-q2y7fewk	41	15	accounts	account	VBZ
cord-257027-q2y7fewk	41	16	for	for	IN
cord-257027-q2y7fewk	41	17	the	the	DT
cord-257027-q2y7fewk	41	18	majority	majority	NN
cord-257027-q2y7fewk	41	19	of	of	IN
cord-257027-q2y7fewk	41	20	meningococcal	meningococcal	JJ
cord-257027-q2y7fewk	41	21	disease	disease	NN
cord-257027-q2y7fewk	41	22	burden	burden	NN
cord-257027-q2y7fewk	41	23	in	in	IN
cord-257027-q2y7fewk	41	24	the	the	DT
cord-257027-q2y7fewk	41	25	United	United	NNP
cord-257027-q2y7fewk	41	26	States	States	NNP
cord-257027-q2y7fewk	41	27	and	and	CC
cord-257027-q2y7fewk	41	28	Europe	Europe	NNP
cord-257027-q2y7fewk	41	29	(	(	-LRB-
cord-257027-q2y7fewk	41	30	9	9	CD
cord-257027-q2y7fewk	41	31	)	)	-RRB-
cord-257027-q2y7fewk	41	32	,	,	,
cord-257027-q2y7fewk	41	33	was	be	VBD
cord-257027-q2y7fewk	41	34	analyzed	analyze	VBN
cord-257027-q2y7fewk	41	35	to	to	TO
cord-257027-q2y7fewk	41	36	identify	identify	VB
cord-257027-q2y7fewk	41	37	candidates	candidate	NNS
cord-257027-q2y7fewk	41	38	for	for	IN
cord-257027-q2y7fewk	41	39	a	a	DT
cord-257027-q2y7fewk	41	40	new	new	JJ
cord-257027-q2y7fewk	41	41	vaccine	vaccine	NN
cord-257027-q2y7fewk	41	42	.	.	.
cord-257027-q2y7fewk	42	1	The	the	DT
cord-257027-q2y7fewk	42	2	bacterial	bacterial	JJ
cord-257027-q2y7fewk	42	3	genome	genome	NN
cord-257027-q2y7fewk	42	4	was	be	VBD
cord-257027-q2y7fewk	42	5	screened	screen	VBN
cord-257027-q2y7fewk	42	6	using	use	VBG
cord-257027-q2y7fewk	42	7	bioinformatics	bioinformatics	NN
cord-257027-q2y7fewk	42	8	tools	tool	NNS
cord-257027-q2y7fewk	42	9	to	to	TO
cord-257027-q2y7fewk	42	10	identify	identify	VB
cord-257027-q2y7fewk	42	11	relatively	relatively	RB
cord-257027-q2y7fewk	42	12	conserved	conserve	VBN
cord-257027-q2y7fewk	42	13	,	,	,
cord-257027-q2y7fewk	42	14	surface	surface	NN
cord-257027-q2y7fewk	42	15	-	-	HYPH
cord-257027-q2y7fewk	42	16	exposed	expose	VBN
cord-257027-q2y7fewk	42	17	outer	outer	JJ
cord-257027-q2y7fewk	42	18	membrane	membrane	NN
cord-257027-q2y7fewk	42	19	protein	protein	NN
cord-257027-q2y7fewk	42	20	antigens	antigen	NNS
cord-257027-q2y7fewk	42	21	:	:	:
cord-257027-q2y7fewk	42	22	570	570	CD
cord-257027-q2y7fewk	42	23	of	of	IN
cord-257027-q2y7fewk	42	24	2158	2158	CD
cord-257027-q2y7fewk	42	25	open	open	JJ
cord-257027-q2y7fewk	42	26	reading	reading	NN
cord-257027-q2y7fewk	42	27	frames	frame	NNS
cord-257027-q2y7fewk	42	28	(	(	-LRB-
cord-257027-q2y7fewk	42	29	ORFs	ORFs	NNP
cord-257027-q2y7fewk	42	30	)	)	-RRB-
cord-257027-q2y7fewk	42	31	were	be	VBD
cord-257027-q2y7fewk	42	32	thus	thus	RB
cord-257027-q2y7fewk	42	33	selected	select	VBN
cord-257027-q2y7fewk	42	34	.	.	.
cord-257027-q2y7fewk	43	1	Immunoproteomics	Immunoproteomics	NNP
cord-257027-q2y7fewk	43	2	methods	method	NNS
cord-257027-q2y7fewk	43	3	were	be	VBD
cord-257027-q2y7fewk	43	4	then	then	RB
cord-257027-q2y7fewk	43	5	used	use	VBN
cord-257027-q2y7fewk	43	6	to	to	TO
cord-257027-q2y7fewk	43	7	select	select	VB
cord-257027-q2y7fewk	43	8	the	the	DT
cord-257027-q2y7fewk	43	9	most	most	RBS
cord-257027-q2y7fewk	43	10	immunogenic	immunogenic	JJ
cord-257027-q2y7fewk	43	11	meningococcal	meningococcal	JJ
cord-257027-q2y7fewk	43	12	antigens	antigen	NNS
cord-257027-q2y7fewk	43	13	that	that	WDT
cord-257027-q2y7fewk	43	14	would	would	MD
cord-257027-q2y7fewk	43	15	elicit	elicit	VB
cord-257027-q2y7fewk	43	16	a	a	DT
cord-257027-q2y7fewk	43	17	protective	protective	JJ
cord-257027-q2y7fewk	43	18	immunity	immunity	NN
cord-257027-q2y7fewk	43	19	.	.	.
cord-257027-q2y7fewk	44	1	Five	five	CD
cord-257027-q2y7fewk	44	2	of	of	IN
cord-257027-q2y7fewk	44	3	28	28	CD
cord-257027-q2y7fewk	44	4	genome	genome	NN
cord-257027-q2y7fewk	44	5	-	-	HYPH
cord-257027-q2y7fewk	44	6	derived	derive	VBN
cord-257027-q2y7fewk	44	7	candidate	candidate	NN
cord-257027-q2y7fewk	44	8	antigens	antigen	NNS
cord-257027-q2y7fewk	44	9	are	be	VBP
cord-257027-q2y7fewk	44	10	components	component	NNS
cord-257027-q2y7fewk	44	11	of	of	IN
cord-257027-q2y7fewk	44	12	a	a	DT
cord-257027-q2y7fewk	44	13	rationally	rationally	RB
cord-257027-q2y7fewk	44	14	designed	design	VBN
cord-257027-q2y7fewk	44	15	vaccine	vaccine	NN
cord-257027-q2y7fewk	44	16	against	against	IN
cord-257027-q2y7fewk	44	17	N.	N.	NNP
cord-257027-q2y7fewk	44	18	meningitidis	meningitidis	NNP
cord-257027-q2y7fewk	44	19	serogroup	serogroup	NNP
cord-257027-q2y7fewk	44	20	B	B	NNP
cord-257027-q2y7fewk	44	21	(	(	-LRB-
cord-257027-q2y7fewk	44	22	10	10	CD
cord-257027-q2y7fewk	44	23	)	)	-RRB-
cord-257027-q2y7fewk	44	24	and	and	CC
cord-257027-q2y7fewk	44	25	a	a	DT
cord-257027-q2y7fewk	44	26	formulation	formulation	NN
cord-257027-q2y7fewk	44	27	of	of	IN
cord-257027-q2y7fewk	44	28	four	four	CD
cord-257027-q2y7fewk	44	29	of	of	IN
cord-257027-q2y7fewk	44	30	these	these	DT
cord-257027-q2y7fewk	44	31	antigens	antigen	NNS
cord-257027-q2y7fewk	44	32	(	(	-LRB-
cord-257027-q2y7fewk	45	1	4CMenB	4cmenb	CD
cord-257027-q2y7fewk	45	2	,	,	,
cord-257027-q2y7fewk	45	3	Novartis	Novartis	NNP
cord-257027-q2y7fewk	45	4	,	,	,
cord-257027-q2y7fewk	45	5	Switzerland	Switzerland	NNP
cord-257027-q2y7fewk	45	6	)	)	-RRB-
cord-257027-q2y7fewk	45	7	has	have	VBZ
cord-257027-q2y7fewk	45	8	induced	induce	VBN
cord-257027-q2y7fewk	45	9	high	high	JJ
cord-257027-q2y7fewk	45	10	titers	titer	NNS
cord-257027-q2y7fewk	45	11	of	of	IN
cord-257027-q2y7fewk	45	12	bactericidal	bactericidal	JJ
cord-257027-q2y7fewk	45	13	antibodies	antibody	NNS
cord-257027-q2y7fewk	45	14	in	in	IN
cord-257027-q2y7fewk	45	15	a	a	DT
cord-257027-q2y7fewk	45	16	phase	phase	NN
cord-257027-q2y7fewk	45	17	I	-PRON-	PRP
cord-257027-q2y7fewk	45	18	/	/	SYM
cord-257027-q2y7fewk	45	19	II	II	NNP
cord-257027-q2y7fewk	45	20	clinical	clinical	JJ
cord-257027-q2y7fewk	45	21	trial	trial	NN
cord-257027-q2y7fewk	45	22	(	(	-LRB-
cord-257027-q2y7fewk	45	23	11	11	CD
cord-257027-q2y7fewk	45	24	)	)	-RRB-
cord-257027-q2y7fewk	45	25	.	.	.
cord-257027-q2y7fewk	46	1	The	the	DT
cord-257027-q2y7fewk	46	2	multivalent	multivalent	JJ
cord-257027-q2y7fewk	46	3	vaccine	vaccine	NN
cord-257027-q2y7fewk	46	4	formulation	formulation	NN
cord-257027-q2y7fewk	46	5	has	have	VBZ
cord-257027-q2y7fewk	46	6	been	be	VBN
cord-257027-q2y7fewk	46	7	proposed	propose	VBN
cord-257027-q2y7fewk	46	8	to	to	TO
cord-257027-q2y7fewk	46	9	overcome	overcome	VB
cord-257027-q2y7fewk	46	10	the	the	DT
cord-257027-q2y7fewk	46	11	issue	issue	NN
cord-257027-q2y7fewk	46	12	of	of	IN
cord-257027-q2y7fewk	46	13	antigenic	antigenic	JJ
cord-257027-q2y7fewk	46	14	diversity	diversity	NN
cord-257027-q2y7fewk	46	15	between	between	IN
cord-257027-q2y7fewk	46	16	strains	strain	NNS
cord-257027-q2y7fewk	46	17	of	of	IN
cord-257027-q2y7fewk	46	18	N.	N.	NNP
cord-257027-q2y7fewk	46	19	meningitidis	meningitidis	NN
cord-257027-q2y7fewk	46	20	,	,	,
cord-257027-q2y7fewk	46	21	and	and	CC
cord-257027-q2y7fewk	46	22	it	-PRON-	PRP
cord-257027-q2y7fewk	46	23	would	would	MD
cord-257027-q2y7fewk	46	24	be	be	VB
cord-257027-q2y7fewk	46	25	expected	expect	VBN
cord-257027-q2y7fewk	46	26	to	to	TO
cord-257027-q2y7fewk	46	27	stimulate	stimulate	VB
cord-257027-q2y7fewk	46	28	immune	immune	JJ
cord-257027-q2y7fewk	46	29	responses	response	NNS
cord-257027-q2y7fewk	46	30	capable	capable	JJ
cord-257027-q2y7fewk	46	31	of	of	IN
cord-257027-q2y7fewk	46	32	recognizing	recognize	VBG
cord-257027-q2y7fewk	46	33	multiple	multiple	JJ
cord-257027-q2y7fewk	46	34	antigenic	antigenic	JJ
cord-257027-q2y7fewk	46	35	variants	variant	NNS
cord-257027-q2y7fewk	46	36	.	.	.
cord-257027-q2y7fewk	47	1	The	the	DT
cord-257027-q2y7fewk	47	2	promising	promising	JJ
cord-257027-q2y7fewk	47	3	results	result	NNS
cord-257027-q2y7fewk	47	4	of	of	IN
cord-257027-q2y7fewk	47	5	this	this	DT
cord-257027-q2y7fewk	47	6	new	new	JJ
cord-257027-q2y7fewk	47	7	vaccine	vaccine	NN
cord-257027-q2y7fewk	47	8	candidate	candidate	NN
cord-257027-q2y7fewk	47	9	may	may	MD
cord-257027-q2y7fewk	47	10	be	be	VB
cord-257027-q2y7fewk	47	11	the	the	DT
cord-257027-q2y7fewk	47	12	critical	critical	JJ
cord-257027-q2y7fewk	47	13	"	"	``
cord-257027-q2y7fewk	47	14	proof	proof	NN
cord-257027-q2y7fewk	47	15	of	of	IN
cord-257027-q2y7fewk	47	16	concept	concept	NN
cord-257027-q2y7fewk	47	17	"	"	''
cord-257027-q2y7fewk	47	18	stage	stage	NN
cord-257027-q2y7fewk	47	19	for	for	IN
cord-257027-q2y7fewk	47	20	this	this	DT
cord-257027-q2y7fewk	47	21	novel	novel	JJ
cord-257027-q2y7fewk	47	22	approach	approach	NN
cord-257027-q2y7fewk	47	23	that	that	WDT
cord-257027-q2y7fewk	47	24	has	have	VBZ
cord-257027-q2y7fewk	47	25	significantly	significantly	RB
cord-257027-q2y7fewk	47	26	shifted	shift	VBN
cord-257027-q2y7fewk	47	27	the	the	DT
cord-257027-q2y7fewk	47	28	paradigm	paradigm	NN
cord-257027-q2y7fewk	47	29	of	of	IN
cord-257027-q2y7fewk	47	30	vaccine	vaccine	NN
cord-257027-q2y7fewk	47	31	development	development	NN
cord-257027-q2y7fewk	47	32	from	from	IN
cord-257027-q2y7fewk	47	33	microbiological	microbiological	JJ
cord-257027-q2y7fewk	47	34	to	to	IN
cord-257027-q2y7fewk	47	35	sequence	sequence	NN
cord-257027-q2y7fewk	47	36	-	-	HYPH
cord-257027-q2y7fewk	47	37	based	base	VBN
cord-257027-q2y7fewk	47	38	approaches	approach	NNS
cord-257027-q2y7fewk	47	39	.	.	.
cord-257027-q2y7fewk	48	1	Genome	genome	NN
cord-257027-q2y7fewk	48	2	-	-	HYPH
cord-257027-q2y7fewk	48	3	wide	wide	JJ
cord-257027-q2y7fewk	48	4	screening	screening	NN
cord-257027-q2y7fewk	48	5	using	use	VBG
cord-257027-q2y7fewk	48	6	functional	functional	JJ
cord-257027-q2y7fewk	48	7	selection	selection	NN
cord-257027-q2y7fewk	48	8	methods	method	NNS
cord-257027-q2y7fewk	48	9	such	such	JJ
cord-257027-q2y7fewk	48	10	as	as	IN
cord-257027-q2y7fewk	48	11	DNA	dna	NN
cord-257027-q2y7fewk	48	12	microarrays	microarray	NNS
cord-257027-q2y7fewk	48	13	,	,	,
cord-257027-q2y7fewk	48	14	gene	gene	NN
cord-257027-q2y7fewk	48	15	knockout	knockout	NN
cord-257027-q2y7fewk	48	16	libraries	library	NNS
cord-257027-q2y7fewk	48	17	,	,	,
cord-257027-q2y7fewk	48	18	or	or	CC
cord-257027-q2y7fewk	48	19	screening	screening	NN
cord-257027-q2y7fewk	48	20	of	of	IN
cord-257027-q2y7fewk	48	21	cDNA	cdna	NN
cord-257027-q2y7fewk	48	22	expression	expression	NN
cord-257027-q2y7fewk	48	23	libraries	library	NNS
cord-257027-q2y7fewk	48	24	using	use	VBG
cord-257027-q2y7fewk	48	25	patients	patient	NNS
cord-257027-q2y7fewk	48	26	'	'	POS
cord-257027-q2y7fewk	48	27	sera	sera	NNP
cord-257027-q2y7fewk	48	28	has	have	VBZ
cord-257027-q2y7fewk	48	29	been	be	VBN
cord-257027-q2y7fewk	48	30	employed	employ	VBN
cord-257027-q2y7fewk	48	31	in	in	IN
cord-257027-q2y7fewk	48	32	the	the	DT
cord-257027-q2y7fewk	48	33	prospection	prospection	NN
cord-257027-q2y7fewk	48	34	of	of	IN
cord-257027-q2y7fewk	48	35	vaccine	vaccine	NN
cord-257027-q2y7fewk	48	36	candidates	candidate	NNS
cord-257027-q2y7fewk	48	37	(	(	-LRB-
cord-257027-q2y7fewk	48	38	reviewed	review	VBN
cord-257027-q2y7fewk	48	39	in	in	IN
cord-257027-q2y7fewk	48	40	Ref	Ref	NNP
cord-257027-q2y7fewk	48	41	.	.	.
cord-257027-q2y7fewk	48	42	12	12	CD
cord-257027-q2y7fewk	48	43	)	)	-RRB-
cord-257027-q2y7fewk	48	44	.	.	.
cord-257027-q2y7fewk	49	1	These	these	DT
cord-257027-q2y7fewk	49	2	approaches	approach	NNS
cord-257027-q2y7fewk	49	3	allow	allow	VBP
cord-257027-q2y7fewk	49	4	the	the	DT
cord-257027-q2y7fewk	49	5	evaluation	evaluation	NN
cord-257027-q2y7fewk	49	6	of	of	IN
cord-257027-q2y7fewk	49	7	the	the	DT
cord-257027-q2y7fewk	49	8	possible	possible	JJ
cord-257027-q2y7fewk	49	9	immunogenic	immunogenic	JJ
cord-257027-q2y7fewk	49	10	and	and	CC
cord-257027-q2y7fewk	49	11	immunoprotective	immunoprotective	JJ
cord-257027-q2y7fewk	49	12	roles	role	NNS
cord-257027-q2y7fewk	49	13	of	of	IN
cord-257027-q2y7fewk	49	14	all	all	DT
cord-257027-q2y7fewk	49	15	molecules	molecule	NNS
cord-257027-q2y7fewk	49	16	(	(	-LRB-
cord-257027-q2y7fewk	49	17	either	either	CC
cord-257027-q2y7fewk	49	18	surface	surface	NN
cord-257027-q2y7fewk	49	19	expressed	express	VBN
cord-257027-q2y7fewk	49	20	or	or	CC
cord-257027-q2y7fewk	49	21	secreted	secrete	VBN
cord-257027-q2y7fewk	49	22	by	by	IN
cord-257027-q2y7fewk	49	23	pathogens	pathogen	NNS
cord-257027-q2y7fewk	49	24	)	)	-RRB-
cord-257027-q2y7fewk	49	25	,	,	,
cord-257027-q2y7fewk	49	26	thereby	thereby	RB
cord-257027-q2y7fewk	49	27	enabling	enable	VBG
cord-257027-q2y7fewk	49	28	the	the	DT
cord-257027-q2y7fewk	49	29	identification	identification	NN
cord-257027-q2y7fewk	49	30	of	of	IN
cord-257027-q2y7fewk	49	31	candidate	candidate	NN
cord-257027-q2y7fewk	49	32	antigens	antigen	NNS
cord-257027-q2y7fewk	49	33	that	that	WDT
cord-257027-q2y7fewk	49	34	were	be	VBD
cord-257027-q2y7fewk	49	35	not	not	RB
cord-257027-q2y7fewk	49	36	identified	identify	VBN
cord-257027-q2y7fewk	49	37	by	by	IN
cord-257027-q2y7fewk	49	38	the	the	DT
cord-257027-q2y7fewk	49	39	methodologies	methodology	NNS
cord-257027-q2y7fewk	49	40	applied	apply	VBN
cord-257027-q2y7fewk	49	41	in	in	IN
cord-257027-q2y7fewk	49	42	conventional	conventional	JJ
cord-257027-q2y7fewk	49	43	vaccinology	vaccinology	NN
cord-257027-q2y7fewk	49	44	.	.	.
cord-257027-q2y7fewk	50	1	This	this	DT
cord-257027-q2y7fewk	50	2	means	mean	VBZ
cord-257027-q2y7fewk	50	3	that	that	IN
cord-257027-q2y7fewk	50	4	even	even	RB
cord-257027-q2y7fewk	50	5	molecules	molecule	NNS
cord-257027-q2y7fewk	50	6	that	that	WDT
cord-257027-q2y7fewk	50	7	are	be	VBP
cord-257027-q2y7fewk	50	8	expressed	express	VBN
cord-257027-q2y7fewk	50	9	at	at	IN
cord-257027-q2y7fewk	50	10	very	very	RB
cord-257027-q2y7fewk	50	11	low	low	JJ
cord-257027-q2y7fewk	50	12	levels	level	NNS
cord-257027-q2y7fewk	50	13	or	or	CC
cord-257027-q2y7fewk	50	14	only	only	RB
cord-257027-q2y7fewk	50	15	under	under	IN
cord-257027-q2y7fewk	50	16	certain	certain	JJ
cord-257027-q2y7fewk	50	17	conditions	condition	NNS
cord-257027-q2y7fewk	50	18	can	can	MD
cord-257027-q2y7fewk	50	19	be	be	VB
cord-257027-q2y7fewk	50	20	tested	test	VBN
cord-257027-q2y7fewk	50	21	for	for	IN
cord-257027-q2y7fewk	50	22	their	-PRON-	PRP$
cord-257027-q2y7fewk	50	23	potential	potential	NN
cord-257027-q2y7fewk	50	24	as	as	IN
cord-257027-q2y7fewk	50	25	candidate	candidate	NN
cord-257027-q2y7fewk	50	26	vaccines	vaccine	NNS
cord-257027-q2y7fewk	50	27	.	.	.
cord-257027-q2y7fewk	51	1	In	in	IN
cord-257027-q2y7fewk	51	2	brief	brief	NN
cord-257027-q2y7fewk	51	3	,	,	,
cord-257027-q2y7fewk	51	4	genomics	genomic	NNS
cord-257027-q2y7fewk	51	5	coupled	couple	VBN
cord-257027-q2y7fewk	51	6	with	with	IN
cord-257027-q2y7fewk	51	7	other	other	JJ
cord-257027-q2y7fewk	51	8	new	new	JJ
cord-257027-q2y7fewk	51	9	"	"	``
cord-257027-q2y7fewk	51	10	omics	omic	NNS
cord-257027-q2y7fewk	51	11	"	"	''
cord-257027-q2y7fewk	51	12	fields	field	NNS
cord-257027-q2y7fewk	51	13	of	of	IN
cord-257027-q2y7fewk	51	14	study	study	NN
cord-257027-q2y7fewk	51	15	such	such	JJ
cord-257027-q2y7fewk	51	16	as	as	IN
cord-257027-q2y7fewk	51	17	www.bjournal.com.br	www.bjournal.com.br	NNP
cord-257027-q2y7fewk	51	18	Braz	Braz	NNP
cord-257027-q2y7fewk	51	19	J	J	NNP
cord-257027-q2y7fewk	51	20	Med	Med	NNP
cord-257027-q2y7fewk	51	21	Biol	Biol	NNP
cord-257027-q2y7fewk	51	22	Res	Res	NNP
cord-257027-q2y7fewk	51	23	45(5	45(5	CD
cord-257027-q2y7fewk	51	24	)	)	-RRB-
cord-257027-q2y7fewk	52	1	2012	2012	CD
cord-257027-q2y7fewk	52	2	transcriptomics	transcriptomic	NNS
cord-257027-q2y7fewk	52	3	,	,	,
cord-257027-q2y7fewk	52	4	proteomics	proteomic	NNS
cord-257027-q2y7fewk	52	5	,	,	,
cord-257027-q2y7fewk	52	6	and	and	CC
cord-257027-q2y7fewk	52	7	immunomics	immunomic	NNS
cord-257027-q2y7fewk	52	8	enables	enable	VBZ
cord-257027-q2y7fewk	52	9	the	the	DT
cord-257027-q2y7fewk	52	10	identification	identification	NN
cord-257027-q2y7fewk	52	11	of	of	IN
cord-257027-q2y7fewk	52	12	vaccine	vaccine	NN
cord-257027-q2y7fewk	52	13	candidate	candidate	NN
cord-257027-q2y7fewk	52	14	molecules	molecule	NNS
cord-257027-q2y7fewk	52	15	based	base	VBN
cord-257027-q2y7fewk	52	16	on	on	IN
cord-257027-q2y7fewk	52	17	pathogen	pathogen	NN
cord-257027-q2y7fewk	52	18	genome	genome	NN
cord-257027-q2y7fewk	52	19	analysis	analysis	NN
cord-257027-q2y7fewk	52	20	.	.	.
cord-257027-q2y7fewk	53	1	High	high	JJ
cord-257027-q2y7fewk	53	2	-	-	HYPH
cord-257027-q2y7fewk	53	3	throughput	throughput	NN
cord-257027-q2y7fewk	53	4	sequencing	sequencing	NN
cord-257027-q2y7fewk	53	5	technologies	technology	NNS
cord-257027-q2y7fewk	53	6	have	have	VBP
cord-257027-q2y7fewk	53	7	also	also	RB
cord-257027-q2y7fewk	53	8	been	be	VBN
cord-257027-q2y7fewk	53	9	used	use	VBN
cord-257027-q2y7fewk	53	10	to	to	TO
cord-257027-q2y7fewk	53	11	understand	understand	VB
cord-257027-q2y7fewk	53	12	the	the	DT
cord-257027-q2y7fewk	53	13	molecular	molecular	JJ
cord-257027-q2y7fewk	53	14	biology	biology	NN
cord-257027-q2y7fewk	53	15	of	of	IN
cord-257027-q2y7fewk	53	16	several	several	JJ
cord-257027-q2y7fewk	53	17	viruses	virus	NNS
cord-257027-q2y7fewk	53	18	and	and	CC
cord-257027-q2y7fewk	53	19	parasites	parasite	NNS
cord-257027-q2y7fewk	53	20	.	.	.
cord-257027-q2y7fewk	54	1	Recently	recently	RB
cord-257027-q2y7fewk	54	2	,	,	,
cord-257027-q2y7fewk	54	3	genomic	genomic	NN
cord-257027-q2y7fewk	54	4	-	-	HYPH
cord-257027-q2y7fewk	54	5	based	base	VBN
cord-257027-q2y7fewk	54	6	approaches	approach	NNS
cord-257027-q2y7fewk	54	7	have	have	VBP
cord-257027-q2y7fewk	54	8	allowed	allow	VBN
cord-257027-q2y7fewk	54	9	the	the	DT
cord-257027-q2y7fewk	54	10	identification	identification	NN
cord-257027-q2y7fewk	54	11	of	of	IN
cord-257027-q2y7fewk	54	12	potential	potential	JJ
cord-257027-q2y7fewk	54	13	novel	novel	JJ
cord-257027-q2y7fewk	54	14	viral	viral	JJ
cord-257027-q2y7fewk	54	15	and	and	CC
cord-257027-q2y7fewk	54	16	parasitic	parasitic	JJ
cord-257027-q2y7fewk	54	17	targets	target	NNS
cord-257027-q2y7fewk	54	18	,	,	,
cord-257027-q2y7fewk	54	19	which	which	WDT
cord-257027-q2y7fewk	54	20	will	will	MD
cord-257027-q2y7fewk	54	21	be	be	VB
cord-257027-q2y7fewk	54	22	included	include	VBN
cord-257027-q2y7fewk	54	23	in	in	IN
cord-257027-q2y7fewk	54	24	vaccines	vaccine	NNS
cord-257027-q2y7fewk	54	25	against	against	IN
cord-257027-q2y7fewk	54	26	infectious	infectious	JJ
cord-257027-q2y7fewk	54	27	diseases	disease	NNS
cord-257027-q2y7fewk	54	28	,	,	,
cord-257027-q2y7fewk	54	29	such	such	JJ
cord-257027-q2y7fewk	54	30	as	as	IN
cord-257027-q2y7fewk	54	31	severe	severe	JJ
cord-257027-q2y7fewk	54	32	acute	acute	JJ
cord-257027-q2y7fewk	54	33	respiratory	respiratory	JJ
cord-257027-q2y7fewk	54	34	syndrome	syndrome	NN
cord-257027-q2y7fewk	54	35	(	(	-LRB-
cord-257027-q2y7fewk	54	36	SARS	SARS	NNP
cord-257027-q2y7fewk	54	37	;	;	:
cord-257027-q2y7fewk	54	38	13	13	CD
cord-257027-q2y7fewk	54	39	)	)	-RRB-
cord-257027-q2y7fewk	54	40	,	,	,
cord-257027-q2y7fewk	54	41	AIDS	AIDS	NNP
cord-257027-q2y7fewk	54	42	(	(	-LRB-
cord-257027-q2y7fewk	54	43	14	14	CD
cord-257027-q2y7fewk	54	44	)	)	-RRB-
cord-257027-q2y7fewk	54	45	,	,	,
cord-257027-q2y7fewk	54	46	trypanosomiasis	trypanosomiasis	NN
cord-257027-q2y7fewk	54	47	(	(	-LRB-
cord-257027-q2y7fewk	54	48	15	15	CD
cord-257027-q2y7fewk	54	49	)	)	-RRB-
cord-257027-q2y7fewk	54	50	,	,	,
cord-257027-q2y7fewk	54	51	and	and	CC
cord-257027-q2y7fewk	54	52	malaria	malaria	NN
cord-257027-q2y7fewk	54	53	(	(	-LRB-
cord-257027-q2y7fewk	54	54	16	16	CD
cord-257027-q2y7fewk	54	55	)	)	-RRB-
cord-257027-q2y7fewk	54	56	.	.	.
cord-257027-q2y7fewk	55	1	Pathogens	pathogen	NNS
cord-257027-q2y7fewk	55	2	have	have	VBP
cord-257027-q2y7fewk	55	3	developed	develop	VBN
cord-257027-q2y7fewk	55	4	multiple	multiple	JJ
cord-257027-q2y7fewk	55	5	strategies	strategy	NNS
cord-257027-q2y7fewk	55	6	to	to	TO
cord-257027-q2y7fewk	55	7	evade	evade	VB
cord-257027-q2y7fewk	55	8	the	the	DT
cord-257027-q2y7fewk	55	9	immune	immune	JJ
cord-257027-q2y7fewk	55	10	response	response	NN
cord-257027-q2y7fewk	55	11	,	,	,
cord-257027-q2y7fewk	55	12	and	and	CC
cord-257027-q2y7fewk	55	13	one	one	CD
cord-257027-q2y7fewk	55	14	of	of	IN
cord-257027-q2y7fewk	55	15	the	the	DT
cord-257027-q2y7fewk	55	16	most	most	RBS
cord-257027-q2y7fewk	55	17	commonly	commonly	RB
cord-257027-q2y7fewk	55	18	used	use	VBN
cord-257027-q2y7fewk	55	19	is	be	VBZ
cord-257027-q2y7fewk	55	20	antigenic	antigenic	JJ
cord-257027-q2y7fewk	55	21	variation	variation	NN
cord-257027-q2y7fewk	55	22	of	of	IN
cord-257027-q2y7fewk	55	23	immune	immune	JJ
cord-257027-q2y7fewk	55	24	response	response	NN
cord-257027-q2y7fewk	55	25	targets	target	NNS
cord-257027-q2y7fewk	55	26	.	.	.
cord-257027-q2y7fewk	56	1	The	the	DT
cord-257027-q2y7fewk	56	2	genetic	genetic	JJ
cord-257027-q2y7fewk	56	3	variability	variability	NN
cord-257027-q2y7fewk	56	4	observed	observe	VBN
cord-257027-q2y7fewk	56	5	in	in	IN
cord-257027-q2y7fewk	56	6	most	most	JJS
cord-257027-q2y7fewk	56	7	microorganisms	microorganism	NNS
cord-257027-q2y7fewk	56	8	,	,	,
cord-257027-q2y7fewk	56	9	especially	especially	RB
cord-257027-q2y7fewk	56	10	those	those	DT
cord-257027-q2y7fewk	56	11	that	that	WDT
cord-257027-q2y7fewk	56	12	are	be	VBP
cord-257027-q2y7fewk	56	13	pathogenic	pathogenic	JJ
cord-257027-q2y7fewk	56	14	,	,	,
cord-257027-q2y7fewk	56	15	accounts	account	VBZ
cord-257027-q2y7fewk	56	16	for	for	IN
cord-257027-q2y7fewk	56	17	the	the	DT
cord-257027-q2y7fewk	56	18	capacity	capacity	NN
cord-257027-q2y7fewk	56	19	of	of	IN
cord-257027-q2y7fewk	56	20	microbial	microbial	JJ
cord-257027-q2y7fewk	56	21	pathogens	pathogen	NNS
cord-257027-q2y7fewk	56	22	to	to	TO
cord-257027-q2y7fewk	56	23	adapt	adapt	VB
cord-257027-q2y7fewk	56	24	to	to	IN
cord-257027-q2y7fewk	56	25	genetically	genetically	RB
cord-257027-q2y7fewk	56	26	distinct	distinct	JJ
cord-257027-q2y7fewk	56	27	hosts	host	NNS
cord-257027-q2y7fewk	56	28	,	,	,
cord-257027-q2y7fewk	56	29	different	different	JJ
cord-257027-q2y7fewk	56	30	antibiotics	antibiotic	NNS
cord-257027-q2y7fewk	56	31	,	,	,
cord-257027-q2y7fewk	56	32	or	or	CC
cord-257027-q2y7fewk	56	33	immune	immune	JJ
cord-257027-q2y7fewk	56	34	system	system	NN
cord-257027-q2y7fewk	56	35	defense	defense	NN
cord-257027-q2y7fewk	56	36	mechanisms	mechanism	NNS
cord-257027-q2y7fewk	56	37	(	(	-LRB-
cord-257027-q2y7fewk	56	38	12	12	CD
cord-257027-q2y7fewk	56	39	)	)	-RRB-
cord-257027-q2y7fewk	56	40	.	.	.
cord-257027-q2y7fewk	57	1	The	the	DT
cord-257027-q2y7fewk	57	2	high	high	JJ
cord-257027-q2y7fewk	57	3	intra	intra	JJ
cord-257027-q2y7fewk	57	4	-	-	JJ
cord-257027-q2y7fewk	57	5	species	species	JJ
cord-257027-q2y7fewk	57	6	variability	variability	NN
cord-257027-q2y7fewk	57	7	is	be	VBZ
cord-257027-q2y7fewk	57	8	an	an	DT
cord-257027-q2y7fewk	57	9	important	important	JJ
cord-257027-q2y7fewk	57	10	limiting	limit	VBG
cord-257027-q2y7fewk	57	11	factor	factor	NN
cord-257027-q2y7fewk	57	12	to	to	IN
cord-257027-q2y7fewk	57	13	the	the	DT
cord-257027-q2y7fewk	57	14	development	development	NN
cord-257027-q2y7fewk	57	15	of	of	IN
cord-257027-q2y7fewk	57	16	vaccines	vaccine	NNS
cord-257027-q2y7fewk	57	17	against	against	IN
cord-257027-q2y7fewk	57	18	several	several	JJ
cord-257027-q2y7fewk	57	19	diseases	disease	NNS
cord-257027-q2y7fewk	57	20	such	such	JJ
cord-257027-q2y7fewk	57	21	as	as	IN
cord-257027-q2y7fewk	57	22	HIV	HIV	NNP
cord-257027-q2y7fewk	57	23	,	,	,
cord-257027-q2y7fewk	57	24	hepatitis	hepatitis	NN
cord-257027-q2y7fewk	57	25	C	C	NNP
cord-257027-q2y7fewk	57	26	virus	virus	NN
cord-257027-q2y7fewk	57	27	(	(	-LRB-
cord-257027-q2y7fewk	57	28	HCV	HCV	NNP
cord-257027-q2y7fewk	57	29	)	)	-RRB-
cord-257027-q2y7fewk	57	30	,	,	,
cord-257027-q2y7fewk	57	31	Plasmodium	Plasmodium	NNP
cord-257027-q2y7fewk	57	32	,	,	,
cord-257027-q2y7fewk	57	33	and	and	CC
cord-257027-q2y7fewk	57	34	Meningococcus	Meningococcus	NNP
cord-257027-q2y7fewk	57	35	.	.	.
cord-257027-q2y7fewk	58	1	Genotypic	Genotypic	NNP
cord-257027-q2y7fewk	58	2	differences	difference	NNS
cord-257027-q2y7fewk	58	3	among	among	IN
cord-257027-q2y7fewk	58	4	infecting	infect	VBG
cord-257027-q2y7fewk	58	5	Mycobacterium	Mycobacterium	NNP
cord-257027-q2y7fewk	58	6	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	58	7	strains	strain	NNS
cord-257027-q2y7fewk	58	8	have	have	VBP
cord-257027-q2y7fewk	58	9	also	also	RB
cord-257027-q2y7fewk	58	10	been	be	VBN
cord-257027-q2y7fewk	58	11	pointed	point	VBN
cord-257027-q2y7fewk	58	12	out	out	RP
cord-257027-q2y7fewk	58	13	as	as	IN
cord-257027-q2y7fewk	58	14	potential	potential	JJ
cord-257027-q2y7fewk	58	15	factors	factor	NNS
cord-257027-q2y7fewk	58	16	influencing	influence	VBG
cord-257027-q2y7fewk	58	17	the	the	DT
cord-257027-q2y7fewk	58	18	efficacy	efficacy	NN
cord-257027-q2y7fewk	58	19	of	of	IN
cord-257027-q2y7fewk	58	20	the	the	DT
cord-257027-q2y7fewk	58	21	Bacillus	Bacillus	NNP
cord-257027-q2y7fewk	58	22	Calmette	Calmette	NNP
cord-257027-q2y7fewk	58	23	-	-	HYPH
cord-257027-q2y7fewk	58	24	Guérin	Guérin	NNP
cord-257027-q2y7fewk	58	25	(	(	-LRB-
cord-257027-q2y7fewk	58	26	BCG	BCG	NNP
cord-257027-q2y7fewk	58	27	)	)	-RRB-
cord-257027-q2y7fewk	58	28	vaccine	vaccine	NN
cord-257027-q2y7fewk	58	29	against	against	IN
cord-257027-q2y7fewk	58	30	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	58	31	(	(	-LRB-
cord-257027-q2y7fewk	58	32	17	17	CD
cord-257027-q2y7fewk	58	33	)	)	-RRB-
cord-257027-q2y7fewk	58	34	.	.	.
cord-257027-q2y7fewk	59	1	This	this	DT
cord-257027-q2y7fewk	59	2	vaccine	vaccine	NN
cord-257027-q2y7fewk	59	3	has	have	VBZ
cord-257027-q2y7fewk	59	4	been	be	VBN
cord-257027-q2y7fewk	59	5	extensively	extensively	RB
cord-257027-q2y7fewk	59	6	used	use	VBN
cord-257027-q2y7fewk	59	7	and	and	CC
cord-257027-q2y7fewk	59	8	studied	study	VBN
cord-257027-q2y7fewk	59	9	,	,	,
cord-257027-q2y7fewk	59	10	and	and	CC
cord-257027-q2y7fewk	59	11	shows	show	VBZ
cord-257027-q2y7fewk	59	12	wide	wide	JJ
cord-257027-q2y7fewk	59	13	variation	variation	NN
cord-257027-q2y7fewk	59	14	in	in	IN
cord-257027-q2y7fewk	59	15	efficacy	efficacy	NN
cord-257027-q2y7fewk	59	16	among	among	IN
cord-257027-q2y7fewk	59	17	populations	population	NNS
cord-257027-q2y7fewk	59	18	and	and	CC
cord-257027-q2y7fewk	59	19	geographic	geographic	JJ
cord-257027-q2y7fewk	59	20	regions	region	NNS
cord-257027-q2y7fewk	59	21	worldwide	worldwide	RB
cord-257027-q2y7fewk	59	22	(	(	-LRB-
cord-257027-q2y7fewk	59	23	18	18	CD
cord-257027-q2y7fewk	59	24	)	)	-RRB-
cord-257027-q2y7fewk	59	25	.	.	.
cord-257027-q2y7fewk	60	1	Entire	entire	JJ
cord-257027-q2y7fewk	60	2	microorganism	microorganism	NN
cord-257027-q2y7fewk	60	3	genome	genome	NN
cord-257027-q2y7fewk	60	4	sequences	sequence	NNS
cord-257027-q2y7fewk	60	5	can	can	MD
cord-257027-q2y7fewk	60	6	be	be	VB
cord-257027-q2y7fewk	60	7	obtained	obtain	VBN
cord-257027-q2y7fewk	60	8	relatively	relatively	RB
cord-257027-q2y7fewk	60	9	inexpensively	inexpensively	RB
cord-257027-q2y7fewk	60	10	and	and	CC
cord-257027-q2y7fewk	60	11	quickly	quickly	RB
cord-257027-q2y7fewk	60	12	,	,	,
cord-257027-q2y7fewk	60	13	a	a	DT
cord-257027-q2y7fewk	60	14	fact	fact	NN
cord-257027-q2y7fewk	60	15	that	that	WDT
cord-257027-q2y7fewk	60	16	makes	make	VBZ
cord-257027-q2y7fewk	60	17	it	-PRON-	PRP
cord-257027-q2y7fewk	60	18	feasible	feasible	JJ
cord-257027-q2y7fewk	60	19	to	to	TO
cord-257027-q2y7fewk	60	20	have	have	VB
cord-257027-q2y7fewk	60	21	whole	whole	JJ
cord-257027-q2y7fewk	60	22	genome	genome	NN
cord-257027-q2y7fewk	60	23	data	datum	NNS
cord-257027-q2y7fewk	60	24	available	available	JJ
cord-257027-q2y7fewk	60	25	from	from	IN
cord-257027-q2y7fewk	60	26	multiple	multiple	JJ
cord-257027-q2y7fewk	60	27	isolates	isolate	NNS
cord-257027-q2y7fewk	60	28	of	of	IN
cord-257027-q2y7fewk	60	29	a	a	DT
cord-257027-q2y7fewk	60	30	single	single	JJ
cord-257027-q2y7fewk	60	31	pathogen	pathogen	NN
cord-257027-q2y7fewk	60	32	.	.	.
cord-257027-q2y7fewk	61	1	This	this	DT
cord-257027-q2y7fewk	61	2	technological	technological	JJ
cord-257027-q2y7fewk	61	3	advance	advance	NN
cord-257027-q2y7fewk	61	4	has	have	VBZ
cord-257027-q2y7fewk	61	5	provided	provide	VBN
cord-257027-q2y7fewk	61	6	the	the	DT
cord-257027-q2y7fewk	61	7	basis	basis	NN
cord-257027-q2y7fewk	61	8	for	for	IN
cord-257027-q2y7fewk	61	9	the	the	DT
cord-257027-q2y7fewk	61	10	exciting	exciting	JJ
cord-257027-q2y7fewk	61	11	,	,	,
cord-257027-q2y7fewk	61	12	newly	newly	RB
cord-257027-q2y7fewk	61	13	proposed	propose	VBN
cord-257027-q2y7fewk	61	14	concept	concept	NN
cord-257027-q2y7fewk	61	15	of	of	IN
cord-257027-q2y7fewk	61	16	Pangenome	Pangenome	NNP
cord-257027-q2y7fewk	61	17	(	(	-LRB-
cord-257027-q2y7fewk	61	18	19	19	CD
cord-257027-q2y7fewk	61	19	)	)	-RRB-
cord-257027-q2y7fewk	61	20	.	.	.
cord-257027-q2y7fewk	62	1	According	accord	VBG
cord-257027-q2y7fewk	62	2	to	to	IN
cord-257027-q2y7fewk	62	3	this	this	DT
cord-257027-q2y7fewk	62	4	concept	concept	NN
cord-257027-q2y7fewk	62	5	,	,	,
cord-257027-q2y7fewk	62	6	a	a	DT
cord-257027-q2y7fewk	62	7	bacterial	bacterial	JJ
cord-257027-q2y7fewk	62	8	species	specie	NNS
cord-257027-q2y7fewk	62	9	could	could	MD
cord-257027-q2y7fewk	62	10	be	be	VB
cord-257027-q2y7fewk	62	11	characterized	characterize	VBN
cord-257027-q2y7fewk	62	12	by	by	IN
cord-257027-q2y7fewk	62	13	its	-PRON-	PRP$
cord-257027-q2y7fewk	62	14	global	global	JJ
cord-257027-q2y7fewk	62	15	gene	gene	NN
cord-257027-q2y7fewk	62	16	repertoire	repertoire	NN
cord-257027-q2y7fewk	62	17	,	,	,
cord-257027-q2y7fewk	62	18	which	which	WDT
cord-257027-q2y7fewk	62	19	contains	contain	VBZ
cord-257027-q2y7fewk	62	20	genes	gene	NNS
cord-257027-q2y7fewk	62	21	shared	share	VBN
cord-257027-q2y7fewk	62	22	by	by	IN
cord-257027-q2y7fewk	62	23	all	all	PDT
cord-257027-q2y7fewk	62	24	the	the	DT
cord-257027-q2y7fewk	62	25	strains	strain	NNS
cord-257027-q2y7fewk	62	26	(	(	-LRB-
cord-257027-q2y7fewk	62	27	core	core	NN
cord-257027-q2y7fewk	62	28	genome	genome	NN
cord-257027-q2y7fewk	62	29	)	)	-RRB-
cord-257027-q2y7fewk	62	30	and	and	CC
cord-257027-q2y7fewk	62	31	genes	gene	NNS
cord-257027-q2y7fewk	62	32	shared	share	VBN
cord-257027-q2y7fewk	62	33	by	by	IN
cord-257027-q2y7fewk	62	34	some	some	DT
cord-257027-q2y7fewk	62	35	strains	strain	NNS
cord-257027-q2y7fewk	62	36	but	but	CC
cord-257027-q2y7fewk	62	37	not	not	RB
cord-257027-q2y7fewk	62	38	all	all	DT
cord-257027-q2y7fewk	62	39	(	(	-LRB-
cord-257027-q2y7fewk	62	40	dispensable	dispensable	JJ
cord-257027-q2y7fewk	62	41	genome	genome	NN
cord-257027-q2y7fewk	62	42	)	)	-RRB-
cord-257027-q2y7fewk	62	43	.	.	.
cord-257027-q2y7fewk	63	1	Additionally	additionally	RB
cord-257027-q2y7fewk	63	2	,	,	,
cord-257027-q2y7fewk	63	3	genetic	genetic	JJ
cord-257027-q2y7fewk	63	4	variants	variant	NNS
cord-257027-q2y7fewk	63	5	in	in	IN
cord-257027-q2y7fewk	63	6	genes	gene	NNS
cord-257027-q2y7fewk	63	7	that	that	WDT
cord-257027-q2y7fewk	63	8	are	be	VBP
cord-257027-q2y7fewk	63	9	found	find	VBN
cord-257027-q2y7fewk	63	10	in	in	IN
cord-257027-q2y7fewk	63	11	all	all	DT
cord-257027-q2y7fewk	63	12	strains	strain	NNS
cord-257027-q2y7fewk	63	13	can	can	MD
cord-257027-q2y7fewk	63	14	be	be	VB
cord-257027-q2y7fewk	63	15	characterized	characterize	VBN
cord-257027-q2y7fewk	63	16	by	by	IN
cord-257027-q2y7fewk	63	17	DNA	dna	NN
cord-257027-q2y7fewk	63	18	sequence	sequence	NN
cord-257027-q2y7fewk	63	19	analysis	analysis	NN
cord-257027-q2y7fewk	63	20	.	.	.
cord-257027-q2y7fewk	64	1	This	this	DT
cord-257027-q2y7fewk	64	2	concept	concept	NN
cord-257027-q2y7fewk	64	3	has	have	VBZ
cord-257027-q2y7fewk	64	4	been	be	VBN
cord-257027-q2y7fewk	64	5	used	use	VBN
cord-257027-q2y7fewk	64	6	to	to	TO
cord-257027-q2y7fewk	64	7	characterize	characterize	VB
cord-257027-q2y7fewk	64	8	intraspecies	intraspecie	NNS
cord-257027-q2y7fewk	64	9	diversity	diversity	NN
cord-257027-q2y7fewk	64	10	in	in	IN
cord-257027-q2y7fewk	64	11	a	a	DT
cord-257027-q2y7fewk	64	12	novel	novel	JJ
cord-257027-q2y7fewk	64	13	approach	approach	NN
cord-257027-q2y7fewk	64	14	for	for	IN
cord-257027-q2y7fewk	64	15	the	the	DT
cord-257027-q2y7fewk	64	16	discovery	discovery	NN
cord-257027-q2y7fewk	64	17	of	of	IN
cord-257027-q2y7fewk	64	18	new	new	JJ
cord-257027-q2y7fewk	64	19	vaccine	vaccine	NN
cord-257027-q2y7fewk	64	20	candidate	candidate	NN
cord-257027-q2y7fewk	64	21	molecules	molecule	NNS
cord-257027-q2y7fewk	64	22	:	:	:
cord-257027-q2y7fewk	64	23	Pangenomics	pangenomic	NNS
cord-257027-q2y7fewk	64	24	reverse	reverse	VBP
cord-257027-q2y7fewk	64	25	vaccinology	vaccinology	NN
cord-257027-q2y7fewk	64	26	(	(	-LRB-
cord-257027-q2y7fewk	64	27	20	20	CD
cord-257027-q2y7fewk	64	28	)	)	-RRB-
cord-257027-q2y7fewk	64	29	.	.	.
cord-257027-q2y7fewk	65	1	Thus	thus	RB
cord-257027-q2y7fewk	65	2	,	,	,
cord-257027-q2y7fewk	65	3	the	the	DT
cord-257027-q2y7fewk	65	4	development	development	NN
cord-257027-q2y7fewk	65	5	of	of	IN
cord-257027-q2y7fewk	65	6	effective	effective	JJ
cord-257027-q2y7fewk	65	7	,	,	,
cord-257027-q2y7fewk	65	8	multivalent	multivalent	JJ
cord-257027-q2y7fewk	65	9	and	and	CC
cord-257027-q2y7fewk	65	10	broad	broad	JJ
cord-257027-q2y7fewk	65	11	coverage	coverage	NN
cord-257027-q2y7fewk	65	12	genome	genome	NN
cord-257027-q2y7fewk	65	13	-	-	HYPH
cord-257027-q2y7fewk	65	14	based	base	VBN
cord-257027-q2y7fewk	65	15	vaccines	vaccine	NNS
cord-257027-q2y7fewk	65	16	will	will	MD
cord-257027-q2y7fewk	65	17	probably	probably	RB
cord-257027-q2y7fewk	65	18	result	result	VB
cord-257027-q2y7fewk	65	19	from	from	IN
cord-257027-q2y7fewk	65	20	approaches	approach	NNS
cord-257027-q2y7fewk	65	21	that	that	WDT
cord-257027-q2y7fewk	65	22	include	include	VBP
cord-257027-q2y7fewk	65	23	genomes	genome	NNS
cord-257027-q2y7fewk	65	24	from	from	IN
cord-257027-q2y7fewk	65	25	multiple	multiple	JJ
cord-257027-q2y7fewk	65	26	isolates	isolate	NNS
cord-257027-q2y7fewk	65	27	from	from	IN
cord-257027-q2y7fewk	65	28	each	each	DT
cord-257027-q2y7fewk	65	29	microbial	microbial	JJ
cord-257027-q2y7fewk	65	30	pathogen	pathogen	NN
cord-257027-q2y7fewk	65	31	.	.	.
cord-257027-q2y7fewk	66	1	Yet	yet	RB
cord-257027-q2y7fewk	66	2	,	,	,
cord-257027-q2y7fewk	66	3	underrepresented	underrepresented	JJ
cord-257027-q2y7fewk	66	4	strains	strain	NNS
cord-257027-q2y7fewk	66	5	not	not	RB
cord-257027-q2y7fewk	66	6	targeted	target	VBN
cord-257027-q2y7fewk	66	7	by	by	IN
cord-257027-q2y7fewk	66	8	the	the	DT
cord-257027-q2y7fewk	66	9	multivalent	multivalent	JJ
cord-257027-q2y7fewk	66	10	vaccine	vaccine	NN
cord-257027-q2y7fewk	66	11	may	may	MD
cord-257027-q2y7fewk	66	12	become	become	VB
cord-257027-q2y7fewk	66	13	a	a	DT
cord-257027-q2y7fewk	66	14	matter	matter	NN
cord-257027-q2y7fewk	66	15	of	of	IN
cord-257027-q2y7fewk	66	16	concern	concern	NN
cord-257027-q2y7fewk	66	17	after	after	IN
cord-257027-q2y7fewk	66	18	broad	broad	JJ
cord-257027-q2y7fewk	66	19	vaccine	vaccine	NN
cord-257027-q2y7fewk	66	20	coverage	coverage	NN
cord-257027-q2y7fewk	66	21	is	be	VBZ
cord-257027-q2y7fewk	66	22	established	establish	VBN
cord-257027-q2y7fewk	66	23	.	.	.
cord-257027-q2y7fewk	67	1	Serotype	Serotype	NNP
cord-257027-q2y7fewk	67	2	replacement	replacement	NN
cord-257027-q2y7fewk	67	3	,	,	,
cord-257027-q2y7fewk	67	4	a	a	DT
cord-257027-q2y7fewk	67	5	phenomenon	phenomenon	NN
cord-257027-q2y7fewk	67	6	by	by	IN
cord-257027-q2y7fewk	67	7	which	which	WDT
cord-257027-q2y7fewk	67	8	minor	minor	JJ
cord-257027-q2y7fewk	67	9	bacterial	bacterial	JJ
cord-257027-q2y7fewk	67	10	serotypes	serotype	NNS
cord-257027-q2y7fewk	67	11	become	become	VBP
cord-257027-q2y7fewk	67	12	predominant	predominant	JJ
cord-257027-q2y7fewk	67	13	over	over	IN
cord-257027-q2y7fewk	67	14	time	time	NN
cord-257027-q2y7fewk	67	15	,	,	,
cord-257027-q2y7fewk	67	16	has	have	VBZ
cord-257027-q2y7fewk	67	17	been	be	VBN
cord-257027-q2y7fewk	67	18	documented	document	VBN
cord-257027-q2y7fewk	67	19	after	after	IN
cord-257027-q2y7fewk	67	20	the	the	DT
cord-257027-q2y7fewk	67	21	introduction	introduction	NN
cord-257027-q2y7fewk	67	22	of	of	IN
cord-257027-q2y7fewk	67	23	the	the	DT
cord-257027-q2y7fewk	67	24	heptavalent	heptavalent	NN
cord-257027-q2y7fewk	67	25	anti	anti	JJ
cord-257027-q2y7fewk	67	26	-	-	JJ
cord-257027-q2y7fewk	67	27	pneumococcal	pneumococcal	JJ
cord-257027-q2y7fewk	67	28	conjugate	conjugate	NN
cord-257027-q2y7fewk	67	29	vaccine	vaccine	NN
cord-257027-q2y7fewk	67	30	.	.	.
cord-257027-q2y7fewk	68	1	It	-PRON-	PRP
cord-257027-q2y7fewk	68	2	can	can	MD
cord-257027-q2y7fewk	68	3	be	be	VB
cord-257027-q2y7fewk	68	4	attributed	attribute	VBN
cord-257027-q2y7fewk	68	5	to	to	IN
cord-257027-q2y7fewk	68	6	the	the	DT
cord-257027-q2y7fewk	68	7	fact	fact	NN
cord-257027-q2y7fewk	68	8	that	that	IN
cord-257027-q2y7fewk	68	9	strains	strain	VBZ
cord-257027-q2y7fewk	68	10	not	not	RB
cord-257027-q2y7fewk	68	11	targeted	target	VBN
cord-257027-q2y7fewk	68	12	by	by	IN
cord-257027-q2y7fewk	68	13	the	the	DT
cord-257027-q2y7fewk	68	14	vaccine	vaccine	NN
cord-257027-q2y7fewk	68	15	are	be	VBP
cord-257027-q2y7fewk	68	16	able	able	JJ
cord-257027-q2y7fewk	68	17	to	to	TO
cord-257027-q2y7fewk	68	18	escape	escape	VB
cord-257027-q2y7fewk	68	19	vaccine	vaccine	NN
cord-257027-q2y7fewk	68	20	selective	selective	JJ
cord-257027-q2y7fewk	68	21	pressure	pressure	NN
cord-257027-q2y7fewk	68	22	(	(	-LRB-
cord-257027-q2y7fewk	68	23	21	21	CD
cord-257027-q2y7fewk	68	24	)	)	-RRB-
cord-257027-q2y7fewk	68	25	.	.	.
cord-257027-q2y7fewk	69	1	The	the	DT
cord-257027-q2y7fewk	69	2	ongoing	ongoing	JJ
cord-257027-q2y7fewk	69	3	efforts	effort	NNS
cord-257027-q2y7fewk	69	4	of	of	IN
cord-257027-q2y7fewk	69	5	data	datum	NNS
cord-257027-q2y7fewk	69	6	mining	mining	NN
cord-257027-q2y7fewk	69	7	for	for	IN
cord-257027-q2y7fewk	69	8	all	all	PDT
cord-257027-q2y7fewk	69	9	the	the	DT
cord-257027-q2y7fewk	69	10	information	information	NN
cord-257027-q2y7fewk	69	11	in	in	IN
cord-257027-q2y7fewk	69	12	pathogen	pathogen	NN
cord-257027-q2y7fewk	69	13	genomes	genome	NNS
cord-257027-q2y7fewk	69	14	already	already	RB
cord-257027-q2y7fewk	69	15	made	make	VBN
cord-257027-q2y7fewk	69	16	available	available	JJ
cord-257027-q2y7fewk	69	17	should	should	MD
cord-257027-q2y7fewk	69	18	effectively	effectively	RB
cord-257027-q2y7fewk	69	19	help	help	VB
cord-257027-q2y7fewk	69	20	to	to	TO
cord-257027-q2y7fewk	69	21	identify	identify	VB
cord-257027-q2y7fewk	69	22	new	new	JJ
cord-257027-q2y7fewk	69	23	potential	potential	JJ
cord-257027-q2y7fewk	69	24	vaccine	vaccine	NN
cord-257027-q2y7fewk	69	25	targets	target	NNS
cord-257027-q2y7fewk	69	26	for	for	IN
cord-257027-q2y7fewk	69	27	most	most	JJS
cord-257027-q2y7fewk	69	28	infectious	infectious	JJ
cord-257027-q2y7fewk	69	29	diseases	disease	NNS
cord-257027-q2y7fewk	69	30	(	(	-LRB-
cord-257027-q2y7fewk	69	31	Figure	figure	NN
cord-257027-q2y7fewk	69	32	1	1	CD
cord-257027-q2y7fewk	69	33	)	)	-RRB-
cord-257027-q2y7fewk	69	34	.	.	.
cord-257027-q2y7fewk	70	1	However	however	RB
cord-257027-q2y7fewk	70	2	,	,	,
cord-257027-q2y7fewk	70	3	these	these	DT
cord-257027-q2y7fewk	70	4	new	new	JJ
cord-257027-q2y7fewk	70	5	approaches	approach	NNS
cord-257027-q2y7fewk	70	6	using	use	VBG
cord-257027-q2y7fewk	70	7	powerful	powerful	JJ
cord-257027-q2y7fewk	70	8	technologies	technology	NNS
cord-257027-q2y7fewk	70	9	(	(	-LRB-
cord-257027-q2y7fewk	70	10	genomic	genomic	JJ
cord-257027-q2y7fewk	70	11	and	and	CC
cord-257027-q2y7fewk	70	12	pangenomic	pangenomic	NNP
cord-257027-q2y7fewk	70	13	reverse	reverse	NNP
cord-257027-q2y7fewk	70	14	vaccinology	vaccinology	NN
cord-257027-q2y7fewk	70	15	;	;	:
cord-257027-q2y7fewk	70	16	functional	functional	JJ
cord-257027-q2y7fewk	70	17	and	and	CC
cord-257027-q2y7fewk	70	18	structural	structural	JJ
cord-257027-q2y7fewk	70	19	genomics	genomic	NNS
cord-257027-q2y7fewk	70	20	)	)	-RRB-
cord-257027-q2y7fewk	70	21	have	have	VBP
cord-257027-q2y7fewk	70	22	advantages	advantage	NNS
cord-257027-q2y7fewk	70	23	and	and	CC
cord-257027-q2y7fewk	70	24	limitations	limitation	NNS
cord-257027-q2y7fewk	70	25	that	that	WDT
cord-257027-q2y7fewk	70	26	should	should	MD
cord-257027-q2y7fewk	70	27	be	be	VB
cord-257027-q2y7fewk	70	28	considered	consider	VBN
cord-257027-q2y7fewk	70	29	in	in	IN
cord-257027-q2y7fewk	70	30	the	the	DT
cord-257027-q2y7fewk	70	31	rational	rational	JJ
cord-257027-q2y7fewk	70	32	design	design	NN
cord-257027-q2y7fewk	70	33	of	of	IN
cord-257027-q2y7fewk	70	34	a	a	DT
cord-257027-q2y7fewk	70	35	vaccine	vaccine	NN
cord-257027-q2y7fewk	70	36	development	development	NN
cord-257027-q2y7fewk	70	37	project	project	NN
cord-257027-q2y7fewk	70	38	.	.	.
cord-257027-q2y7fewk	71	1	In	in	IN
cord-257027-q2y7fewk	71	2	general	general	JJ
cord-257027-q2y7fewk	71	3	,	,	,
cord-257027-q2y7fewk	71	4	the	the	DT
cord-257027-q2y7fewk	71	5	methodologies	methodology	NNS
cord-257027-q2y7fewk	71	6	used	use	VBN
cord-257027-q2y7fewk	71	7	for	for	IN
cord-257027-q2y7fewk	71	8	identification	identification	NN
cord-257027-q2y7fewk	71	9	and	and	CC
cord-257027-q2y7fewk	71	10	analysis	analysis	NN
cord-257027-q2y7fewk	71	11	of	of	IN
cord-257027-q2y7fewk	71	12	vaccine	vaccine	NN
cord-257027-q2y7fewk	71	13	candidate	candidate	NN
cord-257027-q2y7fewk	71	14	antigens	antigen	NNS
cord-257027-q2y7fewk	71	15	are	be	VBP
cord-257027-q2y7fewk	71	16	based	base	VBN
cord-257027-q2y7fewk	71	17	on	on	IN
cord-257027-q2y7fewk	71	18	the	the	DT
cord-257027-q2y7fewk	71	19	assumption	assumption	NN
cord-257027-q2y7fewk	71	20	that	that	IN
cord-257027-q2y7fewk	71	21	surface	surface	NN
cord-257027-q2y7fewk	71	22	and	and	CC
cord-257027-q2y7fewk	71	23	secreted	secrete	VBN
cord-257027-q2y7fewk	71	24	proteins	protein	NNS
cord-257027-q2y7fewk	71	25	will	will	MD
cord-257027-q2y7fewk	71	26	induce	induce	VB
cord-257027-q2y7fewk	71	27	a	a	DT
cord-257027-q2y7fewk	71	28	protective	protective	JJ
cord-257027-q2y7fewk	71	29	humoral	humoral	JJ
cord-257027-q2y7fewk	71	30	immune	immune	JJ
cord-257027-q2y7fewk	71	31	response	response	NN
cord-257027-q2y7fewk	71	32	.	.	.
cord-257027-q2y7fewk	72	1	That	that	DT
cord-257027-q2y7fewk	72	2	is	be	VBZ
cord-257027-q2y7fewk	72	3	true	true	JJ
cord-257027-q2y7fewk	72	4	for	for	IN
cord-257027-q2y7fewk	72	5	almost	almost	RB
cord-257027-q2y7fewk	72	6	all	all	DT
cord-257027-q2y7fewk	72	7	extracellular	extracellular	JJ
cord-257027-q2y7fewk	72	8	pathogens	pathogen	NNS
cord-257027-q2y7fewk	72	9	,	,	,
cord-257027-q2y7fewk	72	10	but	but	CC
cord-257027-q2y7fewk	72	11	the	the	DT
cord-257027-q2y7fewk	72	12	presence	presence	NN
cord-257027-q2y7fewk	72	13	of	of	IN
cord-257027-q2y7fewk	72	14	antibodies	antibody	NNS
cord-257027-q2y7fewk	72	15	is	be	VBZ
cord-257027-q2y7fewk	72	16	not	not	RB
cord-257027-q2y7fewk	72	17	always	always	RB
cord-257027-q2y7fewk	72	18	associated	associate	VBN
cord-257027-q2y7fewk	72	19	with	with	IN
cord-257027-q2y7fewk	72	20	protection	protection	NN
cord-257027-q2y7fewk	72	21	against	against	IN
cord-257027-q2y7fewk	72	22	intracellular	intracellular	JJ
cord-257027-q2y7fewk	72	23	pathogens	pathogen	NNS
cord-257027-q2y7fewk	72	24	.	.	.
cord-257027-q2y7fewk	73	1	Then	then	RB
cord-257027-q2y7fewk	73	2	,	,	,
cord-257027-q2y7fewk	73	3	eliciting	elicit	VBG
cord-257027-q2y7fewk	73	4	both	both	CC
cord-257027-q2y7fewk	73	5	antibody	antibody	NN
cord-257027-q2y7fewk	73	6	and	and	CC
cord-257027-q2y7fewk	73	7	T	t	NN
cord-257027-q2y7fewk	73	8	-	-	HYPH
cord-257027-q2y7fewk	73	9	cell	cell	NN
cord-257027-q2y7fewk	73	10	immune	immune	JJ
cord-257027-q2y7fewk	73	11	responses	response	NNS
cord-257027-q2y7fewk	73	12	can	can	MD
cord-257027-q2y7fewk	73	13	be	be	VB
cord-257027-q2y7fewk	73	14	an	an	DT
cord-257027-q2y7fewk	73	15	important	important	JJ
cord-257027-q2y7fewk	73	16	property	property	NN
cord-257027-q2y7fewk	73	17	of	of	IN
cord-257027-q2y7fewk	73	18	the	the	DT
cord-257027-q2y7fewk	73	19	candidate	candidate	NN
cord-257027-q2y7fewk	73	20	antigens	antigen	NNS
cord-257027-q2y7fewk	73	21	to	to	TO
cord-257027-q2y7fewk	73	22	be	be	VB
cord-257027-q2y7fewk	73	23	evaluated	evaluate	VBN
cord-257027-q2y7fewk	73	24	.	.	.
cord-257027-q2y7fewk	74	1	In	in	IN
cord-257027-q2y7fewk	74	2	fact	fact	NN
cord-257027-q2y7fewk	74	3	,	,	,
cord-257027-q2y7fewk	74	4	despite	despite	IN
cord-257027-q2y7fewk	74	5	the	the	DT
cord-257027-q2y7fewk	74	6	amount	amount	NN
cord-257027-q2y7fewk	74	7	of	of	IN
cord-257027-q2y7fewk	74	8	available	available	JJ
cord-257027-q2y7fewk	74	9	data	datum	NNS
cord-257027-q2y7fewk	74	10	about	about	IN
cord-257027-q2y7fewk	74	11	the	the	DT
cord-257027-q2y7fewk	74	12	genome	genome	NN
cord-257027-q2y7fewk	74	13	of	of	IN
cord-257027-q2y7fewk	74	14	pathogens	pathogen	NNS
cord-257027-q2y7fewk	74	15	and	and	CC
cord-257027-q2y7fewk	74	16	the	the	DT
cord-257027-q2y7fewk	74	17	human	human	JJ
cord-257027-q2y7fewk	74	18	genome	genome	NN
cord-257027-q2y7fewk	74	19	,	,	,
cord-257027-q2y7fewk	74	20	the	the	DT
cord-257027-q2y7fewk	74	21	genes	gene	NNS
cord-257027-q2y7fewk	74	22	,	,	,
cord-257027-q2y7fewk	74	23	molecules	molecule	NNS
cord-257027-q2y7fewk	74	24	,	,	,
cord-257027-q2y7fewk	74	25	and	and	CC
cord-257027-q2y7fewk	74	26	mechanisms	mechanism	NNS
cord-257027-q2y7fewk	74	27	involved	involve	VBN
cord-257027-q2y7fewk	74	28	in	in	IN
cord-257027-q2y7fewk	74	29	pathogen	pathogen	NN
cord-257027-q2y7fewk	74	30	virulence	virulence	NN
cord-257027-q2y7fewk	74	31	or	or	CC
cord-257027-q2y7fewk	74	32	in	in	IN
cord-257027-q2y7fewk	74	33	host	host	NN
cord-257027-q2y7fewk	74	34	defense	defense	NN
cord-257027-q2y7fewk	74	35	are	be	VBP
cord-257027-q2y7fewk	74	36	still	still	RB
cord-257027-q2y7fewk	74	37	not	not	RB
cord-257027-q2y7fewk	74	38	clear	clear	JJ
cord-257027-q2y7fewk	74	39	.	.	.
cord-257027-q2y7fewk	75	1	Understanding	understand	VBG
cord-257027-q2y7fewk	75	2	the	the	DT
cord-257027-q2y7fewk	75	3	mechanisms	mechanism	NNS
cord-257027-q2y7fewk	75	4	of	of	IN
cord-257027-q2y7fewk	75	5	microbial	microbial	JJ
cord-257027-q2y7fewk	75	6	infections	infection	NNS
cord-257027-q2y7fewk	75	7	and	and	CC
cord-257027-q2y7fewk	75	8	the	the	DT
cord-257027-q2y7fewk	75	9	immune	immune	JJ
cord-257027-q2y7fewk	75	10	response	response	NN
cord-257027-q2y7fewk	75	11	against	against	IN
cord-257027-q2y7fewk	75	12	them	-PRON-	PRP
cord-257027-q2y7fewk	75	13	remains	remain	VBZ
cord-257027-q2y7fewk	75	14	a	a	DT
cord-257027-q2y7fewk	75	15	major	major	JJ
cord-257027-q2y7fewk	75	16	challenge	challenge	NN
cord-257027-q2y7fewk	75	17	in	in	IN
cord-257027-q2y7fewk	75	18	vaccine	vaccine	NN
cord-257027-q2y7fewk	75	19	development	development	NN
cord-257027-q2y7fewk	75	20	.	.	.
cord-257027-q2y7fewk	76	1	This	this	DT
cord-257027-q2y7fewk	76	2	could	could	MD
cord-257027-q2y7fewk	76	3	explain	explain	VB
cord-257027-q2y7fewk	76	4	why	why	WRB
cord-257027-q2y7fewk	76	5	relatively	relatively	RB
cord-257027-q2y7fewk	76	6	slow	slow	JJ
cord-257027-q2y7fewk	76	7	progress	progress	NN
cord-257027-q2y7fewk	76	8	has	have	VBZ
cord-257027-q2y7fewk	76	9	been	be	VBN
cord-257027-q2y7fewk	76	10	made	make	VBN
cord-257027-q2y7fewk	76	11	in	in	IN
cord-257027-q2y7fewk	76	12	the	the	DT
cord-257027-q2y7fewk	76	13	development	development	NN
cord-257027-q2y7fewk	76	14	of	of	IN
cord-257027-q2y7fewk	76	15	new	new	JJ
cord-257027-q2y7fewk	76	16	efficient	efficient	JJ
cord-257027-q2y7fewk	76	17	vaccines	vaccine	NNS
cord-257027-q2y7fewk	76	18	in	in	IN
cord-257027-q2y7fewk	76	19	spite	spite	NN
cord-257027-q2y7fewk	76	20	of	of	IN
cord-257027-q2y7fewk	76	21	the	the	DT
cord-257027-q2y7fewk	76	22	emergence	emergence	NN
cord-257027-q2y7fewk	76	23	of	of	IN
cord-257027-q2y7fewk	76	24	high	high	JJ
cord-257027-q2y7fewk	76	25	-	-	HYPH
cord-257027-q2y7fewk	76	26	throughput	throughput	NN
cord-257027-q2y7fewk	76	27	sequencing	sequencing	NN
cord-257027-q2y7fewk	76	28	technologies	technology	NNS
cord-257027-q2y7fewk	76	29	and	and	CC
cord-257027-q2y7fewk	76	30	advances	advance	NNS
cord-257027-q2y7fewk	76	31	in	in	IN
cord-257027-q2y7fewk	76	32	bioinformatics	bioinformatic	NNS
cord-257027-q2y7fewk	76	33	.	.	.
cord-257027-q2y7fewk	77	1	Much	much	JJ
cord-257027-q2y7fewk	77	2	research	research	NN
cord-257027-q2y7fewk	77	3	is	be	VBZ
cord-257027-q2y7fewk	77	4	still	still	RB
cord-257027-q2y7fewk	77	5	needed	need	VBN
cord-257027-q2y7fewk	77	6	for	for	IN
cord-257027-q2y7fewk	77	7	novel	novel	JJ
cord-257027-q2y7fewk	77	8	vaccine	vaccine	NN
cord-257027-q2y7fewk	77	9	development	development	NN
cord-257027-q2y7fewk	77	10	:	:	:
cord-257027-q2y7fewk	77	11	the	the	DT
cord-257027-q2y7fewk	77	12	contribution	contribution	NN
cord-257027-q2y7fewk	77	13	of	of	IN
cord-257027-q2y7fewk	77	14	each	each	DT
cord-257027-q2y7fewk	77	15	microbial	microbial	JJ
cord-257027-q2y7fewk	77	16	gene	gene	NN
cord-257027-q2y7fewk	77	17	expressed	express	VBN
cord-257027-q2y7fewk	77	18	to	to	IN
cord-257027-q2y7fewk	77	19	the	the	DT
cord-257027-q2y7fewk	77	20	disease	disease	NN
cord-257027-q2y7fewk	77	21	and	and	CC
cord-257027-q2y7fewk	77	22	to	to	IN
cord-257027-q2y7fewk	77	23	the	the	DT
cord-257027-q2y7fewk	77	24	activation	activation	NN
cord-257027-q2y7fewk	77	25	of	of	IN
cord-257027-q2y7fewk	77	26	a	a	DT
cord-257027-q2y7fewk	77	27	protective	protective	JJ
cord-257027-q2y7fewk	77	28	immune	immune	JJ
cord-257027-q2y7fewk	77	29	response	response	NN
cord-257027-q2y7fewk	77	30	should	should	MD
cord-257027-q2y7fewk	77	31	be	be	VB
cord-257027-q2y7fewk	77	32	understood	understand	VBN
cord-257027-q2y7fewk	77	33	.	.	.
cord-257027-q2y7fewk	78	1	The	the	DT
cord-257027-q2y7fewk	78	2	current	current	JJ
cord-257027-q2y7fewk	78	3	data	datum	NNS
cord-257027-q2y7fewk	78	4	show	show	VBP
cord-257027-q2y7fewk	78	5	that	that	IN
cord-257027-q2y7fewk	78	6	there	there	EX
cord-257027-q2y7fewk	78	7	is	be	VBZ
cord-257027-q2y7fewk	78	8	a	a	DT
cord-257027-q2y7fewk	78	9	wide	wide	JJ
cord-257027-q2y7fewk	78	10	variety	variety	NN
cord-257027-q2y7fewk	78	11	of	of	IN
cord-257027-q2y7fewk	78	12	new	new	JJ
cord-257027-q2y7fewk	78	13	molecules	molecule	NNS
cord-257027-q2y7fewk	78	14	that	that	WDT
cord-257027-q2y7fewk	78	15	can	can	MD
cord-257027-q2y7fewk	78	16	potentially	potentially	RB
cord-257027-q2y7fewk	78	17	constitute	constitute	VB
cord-257027-q2y7fewk	78	18	new	new	JJ
cord-257027-q2y7fewk	78	19	vaccine	vaccine	NN
cord-257027-q2y7fewk	78	20	targets	target	NNS
cord-257027-q2y7fewk	78	21	;	;	:
cord-257027-q2y7fewk	78	22	the	the	DT
cord-257027-q2y7fewk	78	23	choice	choice	NN
cord-257027-q2y7fewk	78	24	of	of	IN
cord-257027-q2y7fewk	78	25	the	the	DT
cord-257027-q2y7fewk	78	26	selection	selection	NN
cord-257027-q2y7fewk	78	27	methods	method	NNS
cord-257027-q2y7fewk	78	28	for	for	IN
cord-257027-q2y7fewk	78	29	these	these	DT
cord-257027-q2y7fewk	78	30	new	new	JJ
cord-257027-q2y7fewk	78	31	vaccine	vaccine	NN
cord-257027-q2y7fewk	78	32	antigens	antigen	NNS
cord-257027-q2y7fewk	78	33	is	be	VBZ
cord-257027-q2y7fewk	78	34	,	,	,
cord-257027-q2y7fewk	78	35	thereby	thereby	RB
cord-257027-q2y7fewk	78	36	,	,	,
cord-257027-q2y7fewk	78	37	a	a	DT
cord-257027-q2y7fewk	78	38	critical	critical	JJ
cord-257027-q2y7fewk	78	39	step	step	NN
cord-257027-q2y7fewk	78	40	and	and	CC
cord-257027-q2y7fewk	78	41	depends	depend	VBZ
cord-257027-q2y7fewk	78	42	on	on	IN
cord-257027-q2y7fewk	78	43	the	the	DT
cord-257027-q2y7fewk	78	44	accumulated	accumulate	VBN
cord-257027-q2y7fewk	78	45	knowledge	knowledge	NN
cord-257027-q2y7fewk	78	46	in	in	IN
cord-257027-q2y7fewk	78	47	the	the	DT
cord-257027-q2y7fewk	78	48	fields	field	NNS
cord-257027-q2y7fewk	78	49	of	of	IN
cord-257027-q2y7fewk	78	50	bioinformatics	bioinformatic	NNS
cord-257027-q2y7fewk	78	51	,	,	,
cord-257027-q2y7fewk	78	52	genomics	genomic	NNS
cord-257027-q2y7fewk	78	53	,	,	,
cord-257027-q2y7fewk	78	54	immunology	immunology	NN
cord-257027-q2y7fewk	78	55	,	,	,
cord-257027-q2y7fewk	78	56	pathology	pathology	NN
cord-257027-q2y7fewk	78	57	,	,	,
cord-257027-q2y7fewk	78	58	microbiology	microbiology	NN
cord-257027-q2y7fewk	78	59	,	,	,
cord-257027-q2y7fewk	78	60	parasitology	parasitology	NN
cord-257027-q2y7fewk	78	61	,	,	,
cord-257027-q2y7fewk	78	62	and	and	CC
cord-257027-q2y7fewk	78	63	virology	virology	NN
cord-257027-q2y7fewk	78	64	.	.	.
cord-257027-q2y7fewk	79	1	Host	host	NN
cord-257027-q2y7fewk	79	2	-	-	HYPH
cord-257027-q2y7fewk	79	3	pathogen	pathogen	NN
cord-257027-q2y7fewk	79	4	interactions	interaction	NNS
cord-257027-q2y7fewk	79	5	are	be	VBP
cord-257027-q2y7fewk	79	6	also	also	RB
cord-257027-q2y7fewk	79	7	influenced	influence	VBN
cord-257027-q2y7fewk	79	8	by	by	IN
cord-257027-q2y7fewk	79	9	the	the	DT
cord-257027-q2y7fewk	79	10	host	host	NN
cord-257027-q2y7fewk	79	11	background	background	NN
cord-257027-q2y7fewk	79	12	.	.	.
cord-257027-q2y7fewk	80	1	Thus	thus	RB
cord-257027-q2y7fewk	80	2	,	,	,
cord-257027-q2y7fewk	80	3	different	different	JJ
cord-257027-q2y7fewk	80	4	animal	animal	NN
cord-257027-q2y7fewk	80	5	models	model	NNS
cord-257027-q2y7fewk	80	6	or	or	CC
cord-257027-q2y7fewk	80	7	human	human	JJ
cord-257027-q2y7fewk	80	8	populations	population	NNS
cord-257027-q2y7fewk	80	9	,	,	,
cord-257027-q2y7fewk	80	10	age	age	NN
cord-257027-q2y7fewk	80	11	,	,	,
cord-257027-q2y7fewk	80	12	specific	specific	JJ
cord-257027-q2y7fewk	80	13	nutrient	nutrient	NN
cord-257027-q2y7fewk	80	14	deficiencies	deficiency	NNS
cord-257027-q2y7fewk	80	15	,	,	,
cord-257027-q2y7fewk	80	16	co	co	NNS
cord-257027-q2y7fewk	80	17	-	-	JJ
cord-257027-q2y7fewk	80	18	infection/	infection/	JJ
cord-257027-q2y7fewk	80	19	co	co	NNS
cord-257027-q2y7fewk	80	20	-	-	NNS
cord-257027-q2y7fewk	80	21	morbidities	morbidity	NNS
cord-257027-q2y7fewk	80	22	,	,	,
cord-257027-q2y7fewk	80	23	among	among	IN
cord-257027-q2y7fewk	80	24	other	other	JJ
cord-257027-q2y7fewk	80	25	host	host	NN
cord-257027-q2y7fewk	80	26	conditions	condition	NNS
cord-257027-q2y7fewk	80	27	can	can	MD
cord-257027-q2y7fewk	80	28	influence	influence	VB
cord-257027-q2y7fewk	80	29	the	the	DT
cord-257027-q2y7fewk	80	30	immune	immune	JJ
cord-257027-q2y7fewk	80	31	responses	response	NNS
cord-257027-q2y7fewk	80	32	to	to	IN
cord-257027-q2y7fewk	80	33	a	a	DT
cord-257027-q2y7fewk	80	34	given	give	VBN
cord-257027-q2y7fewk	80	35	pathogen	pathogen	NN
cord-257027-q2y7fewk	80	36	or	or	CC
cord-257027-q2y7fewk	80	37	vaccine	vaccine	NN
cord-257027-q2y7fewk	80	38	.	.	.
cord-257027-q2y7fewk	81	1	There	there	EX
cord-257027-q2y7fewk	81	2	is	be	VBZ
cord-257027-q2y7fewk	81	3	accumulating	accumulate	VBG
cord-257027-q2y7fewk	81	4	evidence	evidence	NN
cord-257027-q2y7fewk	81	5	for	for	IN
cord-257027-q2y7fewk	81	6	a	a	DT
cord-257027-q2y7fewk	81	7	genetic	genetic	JJ
cord-257027-q2y7fewk	81	8	control	control	NN
cord-257027-q2y7fewk	81	9	of	of	IN
cord-257027-q2y7fewk	81	10	infectious	infectious	JJ
cord-257027-q2y7fewk	81	11	diseases	disease	NNS
cord-257027-q2y7fewk	81	12	.	.	.
cord-257027-q2y7fewk	82	1	Rare	rare	JJ
cord-257027-q2y7fewk	82	2	primary	primary	JJ
cord-257027-q2y7fewk	82	3	immunodeficiencies	immunodeficiency	NNS
cord-257027-q2y7fewk	82	4	have	have	VBP
cord-257027-q2y7fewk	82	5	been	be	VBN
cord-257027-q2y7fewk	82	6	shown	show	VBN
cord-257027-q2y7fewk	82	7	to	to	TO
cord-257027-q2y7fewk	82	8	cause	cause	VB
cord-257027-q2y7fewk	82	9	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	82	10	to	to	IN
cord-257027-q2y7fewk	82	11	either	either	CC
cord-257027-q2y7fewk	82	12	multiple	multiple	JJ
cord-257027-q2y7fewk	82	13	infectious	infectious	JJ
cord-257027-q2y7fewk	82	14	agents	agent	NNS
cord-257027-q2y7fewk	82	15	or	or	CC
cord-257027-q2y7fewk	82	16	to	to	IN
cord-257027-q2y7fewk	82	17	a	a	DT
cord-257027-q2y7fewk	82	18	single	single	JJ
cord-257027-q2y7fewk	82	19	type	type	NN
cord-257027-q2y7fewk	82	20	of	of	IN
cord-257027-q2y7fewk	82	21	infectious	infectious	JJ
cord-257027-q2y7fewk	82	22	agent	agent	NN
cord-257027-q2y7fewk	82	23	;	;	:
cord-257027-q2y7fewk	82	24	these	these	DT
cord-257027-q2y7fewk	82	25	are	be	VBP
cord-257027-q2y7fewk	82	26	very	very	RB
cord-257027-q2y7fewk	82	27	rare	rare	JJ
cord-257027-q2y7fewk	82	28	and	and	CC
cord-257027-q2y7fewk	82	29	Mendelian	mendelian	JJ
cord-257027-q2y7fewk	82	30	inherited	inherit	VBD
cord-257027-q2y7fewk	82	31	.	.	.
cord-257027-q2y7fewk	83	1	Twin	twin	JJ
cord-257027-q2y7fewk	83	2	studies	study	NNS
cord-257027-q2y7fewk	83	3	have	have	VBP
cord-257027-q2y7fewk	83	4	provided	provide	VBN
cord-257027-q2y7fewk	83	5	further	further	JJ
cord-257027-q2y7fewk	83	6	evidence	evidence	NN
cord-257027-q2y7fewk	83	7	of	of	IN
cord-257027-q2y7fewk	83	8	a	a	DT
cord-257027-q2y7fewk	83	9	genetic	genetic	JJ
cord-257027-q2y7fewk	83	10	control	control	NN
cord-257027-q2y7fewk	83	11	,	,	,
cord-257027-q2y7fewk	83	12	and	and	CC
cord-257027-q2y7fewk	83	13	complex	complex	JJ
cord-257027-q2y7fewk	83	14	segregation	segregation	NN
cord-257027-q2y7fewk	83	15	analyses	analysis	NNS
cord-257027-q2y7fewk	83	16	that	that	WDT
cord-257027-q2y7fewk	83	17	explicitly	explicitly	RB
cord-257027-q2y7fewk	83	18	model	model	VBP
cord-257027-q2y7fewk	83	19	the	the	DT
cord-257027-q2y7fewk	83	20	effect	effect	NN
cord-257027-q2y7fewk	83	21	of	of	IN
cord-257027-q2y7fewk	83	22	genes	gene	NNS
cord-257027-q2y7fewk	83	23	and	and	CC
cord-257027-q2y7fewk	83	24	the	the	DT
cord-257027-q2y7fewk	83	25	environment	environment	NN
cord-257027-q2y7fewk	83	26	have	have	VBP
cord-257027-q2y7fewk	83	27	revealed	reveal	VBN
cord-257027-q2y7fewk	83	28	either	either	CC
cord-257027-q2y7fewk	83	29	multigenic	multigenic	JJ
cord-257027-q2y7fewk	83	30	predisposition	predisposition	NN
cord-257027-q2y7fewk	83	31	or	or	CC
cord-257027-q2y7fewk	83	32	a	a	DT
cord-257027-q2y7fewk	83	33	genetic	genetic	JJ
cord-257027-q2y7fewk	83	34	predisposition	predisposition	NN
cord-257027-q2y7fewk	83	35	based	base	VBN
cord-257027-q2y7fewk	83	36	on	on	IN
cord-257027-q2y7fewk	83	37	major	major	JJ
cord-257027-q2y7fewk	83	38	genes	gene	NNS
cord-257027-q2y7fewk	83	39	having	have	VBG
cord-257027-q2y7fewk	83	40	a	a	DT
cord-257027-q2y7fewk	83	41	big	big	JJ
cord-257027-q2y7fewk	83	42	influence	influence	NN
cord-257027-q2y7fewk	83	43	on	on	IN
cord-257027-q2y7fewk	83	44	the	the	DT
cord-257027-q2y7fewk	83	45	phenotypes	phenotype	NNS
cord-257027-q2y7fewk	83	46	related	relate	VBN
cord-257027-q2y7fewk	83	47	to	to	IN
cord-257027-q2y7fewk	83	48	the	the	DT
cord-257027-q2y7fewk	83	49	disease	disease	NN
cord-257027-q2y7fewk	83	50	(	(	-LRB-
cord-257027-q2y7fewk	83	51	22	22	CD
cord-257027-q2y7fewk	83	52	)	)	-RRB-
cord-257027-q2y7fewk	83	53	.	.	.
cord-257027-q2y7fewk	84	1	Several	several	JJ
cord-257027-q2y7fewk	84	2	candidate	candidate	NN
cord-257027-q2y7fewk	84	3	genes	gene	NNS
cord-257027-q2y7fewk	84	4	have	have	VBP
cord-257027-q2y7fewk	84	5	been	be	VBN
cord-257027-q2y7fewk	84	6	associated	associate	VBN
cord-257027-q2y7fewk	84	7	with	with	IN
cord-257027-q2y7fewk	84	8	infectious	infectious	JJ
cord-257027-q2y7fewk	84	9	diseases	disease	NNS
cord-257027-q2y7fewk	84	10	(	(	-LRB-
cord-257027-q2y7fewk	84	11	23	23	CD
cord-257027-q2y7fewk	84	12	)	)	-RRB-
cord-257027-q2y7fewk	84	13	.	.	.
cord-257027-q2y7fewk	85	1	The	the	DT
cord-257027-q2y7fewk	85	2	candidate	candidate	NN
cord-257027-q2y7fewk	85	3	gene	gene	NN
cord-257027-q2y7fewk	85	4	approach	approach	NN
cord-257027-q2y7fewk	85	5	further	further	RB
cord-257027-q2y7fewk	85	6	supports	support	VBZ
cord-257027-q2y7fewk	85	7	the	the	DT
cord-257027-q2y7fewk	85	8	role	role	NN
cord-257027-q2y7fewk	85	9	of	of	IN
cord-257027-q2y7fewk	85	10	human	human	JJ
cord-257027-q2y7fewk	85	11	genetics	genetic	NNS
cord-257027-q2y7fewk	85	12	in	in	IN
cord-257027-q2y7fewk	85	13	resistance	resistance	NN
cord-257027-q2y7fewk	85	14	or	or	CC
cord-257027-q2y7fewk	85	15	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	85	16	to	to	IN
cord-257027-q2y7fewk	85	17	infectious	infectious	JJ
cord-257027-q2y7fewk	85	18	diseases	disease	NNS
cord-257027-q2y7fewk	85	19	.	.	.
cord-257027-q2y7fewk	86	1	More	more	RBR
cord-257027-q2y7fewk	86	2	recently	recently	RB
cord-257027-q2y7fewk	86	3	,	,	,
cord-257027-q2y7fewk	86	4	RNA	RNA	NNP
cord-257027-q2y7fewk	86	5	interference	interference	NN
cord-257027-q2y7fewk	86	6	has	have	VBZ
cord-257027-q2y7fewk	86	7	been	be	VBN
cord-257027-q2y7fewk	86	8	used	use	VBN
cord-257027-q2y7fewk	86	9	to	to	TO
cord-257027-q2y7fewk	86	10	exploit	exploit	VB
cord-257027-q2y7fewk	86	11	human	human	JJ
cord-257027-q2y7fewk	86	12	cell	cell	NN
cord-257027-q2y7fewk	86	13	models	model	NNS
cord-257027-q2y7fewk	86	14	of	of	IN
cord-257027-q2y7fewk	86	15	infection	infection	NN
cord-257027-q2y7fewk	86	16	with	with	IN
cord-257027-q2y7fewk	86	17	various	various	JJ
cord-257027-q2y7fewk	86	18	agents	agent	NNS
cord-257027-q2y7fewk	86	19	to	to	TO
cord-257027-q2y7fewk	86	20	elucidate	elucidate	VB
cord-257027-q2y7fewk	86	21	pathogen	pathogen	NN
cord-257027-q2y7fewk	86	22	virulence	virulence	NN
cord-257027-q2y7fewk	86	23	mechanisms	mechanism	NNS
cord-257027-q2y7fewk	86	24	capable	capable	JJ
cord-257027-q2y7fewk	86	25	of	of	IN
cord-257027-q2y7fewk	86	26	subverting	subvert	VBG
cord-257027-q2y7fewk	86	27	host	host	NN
cord-257027-q2y7fewk	86	28	pathways	pathway	NNS
cord-257027-q2y7fewk	86	29	involved	involve	VBN
cord-257027-q2y7fewk	86	30	in	in	IN
cord-257027-q2y7fewk	86	31	immune	immune	JJ
cord-257027-q2y7fewk	86	32	regulation	regulation	NN
cord-257027-q2y7fewk	86	33	and	and	CC
cord-257027-q2y7fewk	86	34	pathogen	pathogen	NN
cord-257027-q2y7fewk	86	35	killing	kill	VBG
cord-257027-q2y7fewk	86	36	response	response	NN
cord-257027-q2y7fewk	86	37	(	(	-LRB-
cord-257027-q2y7fewk	86	38	24	24	CD
cord-257027-q2y7fewk	86	39	)	)	-RRB-
cord-257027-q2y7fewk	86	40	,	,	,
cord-257027-q2y7fewk	86	41	an	an	DT
cord-257027-q2y7fewk	86	42	approach	approach	NN
cord-257027-q2y7fewk	86	43	that	that	WDT
cord-257027-q2y7fewk	86	44	can	can	MD
cord-257027-q2y7fewk	86	45	be	be	VB
cord-257027-q2y7fewk	86	46	used	use	VBN
cord-257027-q2y7fewk	86	47	to	to	TO
cord-257027-q2y7fewk	86	48	discover	discover	VB
cord-257027-q2y7fewk	86	49	and	and	CC
cord-257027-q2y7fewk	86	50	associate	associate	VB
cord-257027-q2y7fewk	86	51	differences	difference	NNS
cord-257027-q2y7fewk	86	52	in	in	IN
cord-257027-q2y7fewk	86	53	preferential	preferential	JJ
cord-257027-q2y7fewk	86	54	immunoregulatory	immunoregulatory	JJ
cord-257027-q2y7fewk	86	55	networks	network	NNS
cord-257027-q2y7fewk	86	56	involved	involve	VBN
cord-257027-q2y7fewk	86	57	in	in	IN
cord-257027-q2y7fewk	86	58	host	host	NN
cord-257027-q2y7fewk	86	59	-	-	HYPH
cord-257027-q2y7fewk	86	60	pathogen	pathogen	NN
cord-257027-q2y7fewk	86	61	interactions	interaction	NNS
cord-257027-q2y7fewk	86	62	in	in	IN
cord-257027-q2y7fewk	86	63	susceptible	susceptible	JJ
cord-257027-q2y7fewk	86	64	versus	versus	IN
cord-257027-q2y7fewk	86	65	resistant	resistant	JJ
cord-257027-q2y7fewk	86	66	hosts	host	NNS
cord-257027-q2y7fewk	86	67	.	.	.
cord-257027-q2y7fewk	87	1	These	these	DT
cord-257027-q2y7fewk	87	2	approaches	approach	NNS
cord-257027-q2y7fewk	87	3	are	be	VBP
cord-257027-q2y7fewk	87	4	,	,	,
cord-257027-q2y7fewk	87	5	however	however	RB
cord-257027-q2y7fewk	87	6	,	,	,
cord-257027-q2y7fewk	87	7	restricted	restrict	VBN
cord-257027-q2y7fewk	87	8	to	to	IN
cord-257027-q2y7fewk	87	9	well	well	RB
cord-257027-q2y7fewk	87	10	-	-	HYPH
cord-257027-q2y7fewk	87	11	known	know	VBN
cord-257027-q2y7fewk	87	12	genes	gene	NNS
cord-257027-q2y7fewk	87	13	.	.	.
cord-257027-q2y7fewk	88	1	Several	several	JJ
cord-257027-q2y7fewk	88	2	genome	genome	NN
cord-257027-q2y7fewk	88	3	-	-	HYPH
cord-257027-q2y7fewk	88	4	wide	wide	JJ
cord-257027-q2y7fewk	88	5	linkage	linkage	NN
cord-257027-q2y7fewk	88	6	analyses	analysis	NNS
cord-257027-q2y7fewk	88	7	have	have	VBP
cord-257027-q2y7fewk	88	8	been	be	VBN
cord-257027-q2y7fewk	88	9	performed	perform	VBN
cord-257027-q2y7fewk	88	10	to	to	TO
cord-257027-q2y7fewk	88	11	map	map	VB
cord-257027-q2y7fewk	88	12	new	new	JJ
cord-257027-q2y7fewk	88	13	resistance	resistance	NN
cord-257027-q2y7fewk	88	14	or	or	CC
cord-257027-q2y7fewk	88	15	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	88	16	genes	gene	NNS
cord-257027-q2y7fewk	88	17	.	.	.
cord-257027-q2y7fewk	89	1	Major	major	JJ
cord-257027-q2y7fewk	89	2	genes	gene	NNS
cord-257027-q2y7fewk	89	3	have	have	VBP
cord-257027-q2y7fewk	89	4	been	be	VBN
cord-257027-q2y7fewk	89	5	mapped	map	VBN
cord-257027-q2y7fewk	89	6	to	to	IN
cord-257027-q2y7fewk	89	7	chromosomes	chromosome	NNS
cord-257027-q2y7fewk	89	8	5q31-q33	5q31-q33	CD
cord-257027-q2y7fewk	89	9	(	(	-LRB-
cord-257027-q2y7fewk	89	10	25	25	CD
cord-257027-q2y7fewk	89	11	)	)	-RRB-
cord-257027-q2y7fewk	89	12	and	and	CC
cord-257027-q2y7fewk	89	13	6q23	6q23	CD
cord-257027-q2y7fewk	89	14	(	(	-LRB-
cord-257027-q2y7fewk	89	15	26	26	CD
cord-257027-q2y7fewk	89	16	)	)	-RRB-
cord-257027-q2y7fewk	89	17	for	for	IN
cord-257027-q2y7fewk	89	18	schistosomiasis	schistosomiasis	NN
cord-257027-q2y7fewk	89	19	,	,	,
cord-257027-q2y7fewk	89	20	chromosomes	chromosome	NNS
cord-257027-q2y7fewk	89	21	8q12	8q12	CD
cord-257027-q2y7fewk	89	22	(	(	-LRB-
cord-257027-q2y7fewk	89	23	27	27	CD
cord-257027-q2y7fewk	89	24	)	)	-RRB-
cord-257027-q2y7fewk	89	25	and	and	CC
cord-257027-q2y7fewk	89	26	15q/	15q/	CD
cord-257027-q2y7fewk	90	1	Xq	Xq	NNP
cord-257027-q2y7fewk	90	2	(	(	-LRB-
cord-257027-q2y7fewk	90	3	27	27	CD
cord-257027-q2y7fewk	90	4	,	,	,
cord-257027-q2y7fewk	90	5	28	28	CD
cord-257027-q2y7fewk	90	6	)	)	-RRB-
cord-257027-q2y7fewk	90	7	for	for	IN
cord-257027-q2y7fewk	90	8	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	90	9	,	,	,
cord-257027-q2y7fewk	90	10	chromosomes	chromosome	VBZ
cord-257027-q2y7fewk	90	11	10p13	10p13	CD
cord-257027-q2y7fewk	90	12	(	(	-LRB-
cord-257027-q2y7fewk	90	13	29	29	CD
cord-257027-q2y7fewk	90	14	,	,	,
cord-257027-q2y7fewk	90	15	30	30	CD
cord-257027-q2y7fewk	90	16	)	)	-RRB-
cord-257027-q2y7fewk	90	17	and	and	CC
cord-257027-q2y7fewk	90	18	6q25	6q25	CD
cord-257027-q2y7fewk	90	19	(	(	-LRB-
cord-257027-q2y7fewk	90	20	30	30	CD
cord-257027-q2y7fewk	90	21	)	)	-RRB-
cord-257027-q2y7fewk	90	22	for	for	IN
cord-257027-q2y7fewk	90	23	leprosy	leprosy	NN
cord-257027-q2y7fewk	90	24	,	,	,
cord-257027-q2y7fewk	90	25	and	and	CC
cord-257027-q2y7fewk	90	26	chromosome	chromosome	NN
cord-257027-q2y7fewk	90	27	22q12	22q12	CD
cord-257027-q2y7fewk	90	28	for	for	IN
cord-257027-q2y7fewk	90	29	visceral	visceral	JJ
cord-257027-q2y7fewk	90	30	leishmaniasis	leishmaniasis	NN
cord-257027-q2y7fewk	90	31	(	(	-LRB-
cord-257027-q2y7fewk	90	32	31	31	CD
cord-257027-q2y7fewk	90	33	)	)	-RRB-
cord-257027-q2y7fewk	90	34	.	.	.
cord-257027-q2y7fewk	91	1	Blood	blood	NN
cord-257027-q2y7fewk	91	2	infection	infection	NN
cord-257027-q2y7fewk	91	3	loads	load	NNS
cord-257027-q2y7fewk	91	4	of	of	IN
cord-257027-q2y7fewk	91	5	Plasmodium	Plasmodium	NNP
cord-257027-q2y7fewk	91	6	falciparum	falciparum	NNS
cord-257027-q2y7fewk	91	7	or	or	CC
cord-257027-q2y7fewk	91	8	mild	mild	JJ
cord-257027-q2y7fewk	91	9	malaria	malaria	NN
cord-257027-q2y7fewk	91	10	have	have	VBP
cord-257027-q2y7fewk	91	11	been	be	VBN
cord-257027-q2y7fewk	91	12	genetically	genetically	RB
cord-257027-q2y7fewk	91	13	linked	link	VBN
cord-257027-q2y7fewk	91	14	to	to	IN
cord-257027-q2y7fewk	91	15	chromosomes	chromosome	NNS
cord-257027-q2y7fewk	91	16	5q31-q33	5q31-q33	CD
cord-257027-q2y7fewk	91	17	(	(	-LRB-
cord-257027-q2y7fewk	91	18	32	32	CD
cord-257027-q2y7fewk	91	19	)	)	-RRB-
cord-257027-q2y7fewk	91	20	,	,	,
cord-257027-q2y7fewk	91	21	5p15	5p15	CD
cord-257027-q2y7fewk	91	22	(	(	-LRB-
cord-257027-q2y7fewk	91	23	33	33	CD
cord-257027-q2y7fewk	91	24	)	)	-RRB-
cord-257027-q2y7fewk	91	25	,	,	,
cord-257027-q2y7fewk	91	26	6p21	6p21	CD
cord-257027-q2y7fewk	91	27	-	-	SYM
cord-257027-q2y7fewk	91	28	23	23	CD
cord-257027-q2y7fewk	91	29	(	(	-LRB-
cord-257027-q2y7fewk	91	30	34	34	CD
cord-257027-q2y7fewk	91	31	)	)	-RRB-
cord-257027-q2y7fewk	91	32	,	,	,
cord-257027-q2y7fewk	91	33	and	and	CC
cord-257027-q2y7fewk	91	34	13q12	13q12	CD
cord-257027-q2y7fewk	91	35	-	-	SYM
cord-257027-q2y7fewk	91	36	22	22	CD
cord-257027-q2y7fewk	91	37	(	(	-LRB-
cord-257027-q2y7fewk	91	38	35	35	CD
cord-257027-q2y7fewk	91	39	)	)	-RRB-
cord-257027-q2y7fewk	91	40	.	.	.
cord-257027-q2y7fewk	92	1	The	the	DT
cord-257027-q2y7fewk	92	2	identification	identification	NN
cord-257027-q2y7fewk	92	3	of	of	IN
cord-257027-q2y7fewk	92	4	genes	gene	NNS
cord-257027-q2y7fewk	92	5	underlying	underlie	VBG
cord-257027-q2y7fewk	92	6	complex	complex	JJ
cord-257027-q2y7fewk	92	7	diseases	disease	NNS
cord-257027-q2y7fewk	92	8	remains	remain	VBZ
cord-257027-q2y7fewk	92	9	a	a	DT
cord-257027-q2y7fewk	92	10	challenging	challenging	JJ
cord-257027-q2y7fewk	92	11	task	task	NN
cord-257027-q2y7fewk	92	12	,	,	,
cord-257027-q2y7fewk	92	13	and	and	CC
cord-257027-q2y7fewk	92	14	few	few	JJ
cord-257027-q2y7fewk	92	15	genes	gene	NNS
cord-257027-q2y7fewk	92	16	have	have	VBP
cord-257027-q2y7fewk	92	17	been	be	VBN
cord-257027-q2y7fewk	92	18	identified	identify	VBN
cord-257027-q2y7fewk	92	19	.	.	.
cord-257027-q2y7fewk	93	1	Nevertheless	nevertheless	RB
cord-257027-q2y7fewk	93	2	,	,	,
cord-257027-q2y7fewk	93	3	IL13	IL13	NNP
cord-257027-q2y7fewk	93	4	(	(	-LRB-
cord-257027-q2y7fewk	93	5	chromosome	chromosome	NN
cord-257027-q2y7fewk	93	6	5q31-q33	5q31-q33	CD
cord-257027-q2y7fewk	93	7	)	)	-RRB-
cord-257027-q2y7fewk	93	8	,	,	,
cord-257027-q2y7fewk	93	9	TNF	TNF	NNP
cord-257027-q2y7fewk	93	10	and	and	CC
cord-257027-q2y7fewk	93	11	NCR3	NCR3	NNP
cord-257027-q2y7fewk	93	12	(	(	-LRB-
cord-257027-q2y7fewk	93	13	chromosome	chromosome	NN
cord-257027-q2y7fewk	93	14	6p21-p23	6p21-p23	CD
cord-257027-q2y7fewk	93	15	)	)	-RRB-
cord-257027-q2y7fewk	93	16	,	,	.
cord-257027-q2y7fewk	94	1	PARK2	PARK2	NNP
cord-257027-q2y7fewk	94	2	and	and	CC
cord-257027-q2y7fewk	94	3	PACRG	PACRG	NNP
cord-257027-q2y7fewk	94	4	(	(	-LRB-
cord-257027-q2y7fewk	94	5	chromosome	chromosome	NN
cord-257027-q2y7fewk	94	6	6q25	6q25	CD
cord-257027-q2y7fewk	94	7	)	)	-RRB-
cord-257027-q2y7fewk	95	1	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	95	2	have	have	VBP
cord-257027-q2y7fewk	95	3	been	be	VBN
cord-257027-q2y7fewk	95	4	associated	associate	VBN
cord-257027-q2y7fewk	95	5	with	with	IN
cord-257027-q2y7fewk	95	6	schistosomiasis	schistosomiasis	NN
cord-257027-q2y7fewk	95	7	(	(	-LRB-
cord-257027-q2y7fewk	95	8	36	36	CD
cord-257027-q2y7fewk	95	9	)	)	-RRB-
cord-257027-q2y7fewk	95	10	,	,	,
cord-257027-q2y7fewk	95	11	mild	mild	JJ
cord-257027-q2y7fewk	95	12	malaria	malaria	NN
cord-257027-q2y7fewk	95	13	(	(	-LRB-
cord-257027-q2y7fewk	95	14	37	37	CD
cord-257027-q2y7fewk	95	15	,	,	,
cord-257027-q2y7fewk	95	16	38	38	CD
cord-257027-q2y7fewk	95	17	)	)	-RRB-
cord-257027-q2y7fewk	95	18	,	,	,
cord-257027-q2y7fewk	95	19	and	and	CC
cord-257027-q2y7fewk	95	20	leprosy	leprosy	NN
cord-257027-q2y7fewk	95	21	(	(	-LRB-
cord-257027-q2y7fewk	95	22	39	39	CD
cord-257027-q2y7fewk	95	23	)	)	-RRB-
cord-257027-q2y7fewk	95	24	,	,	,
cord-257027-q2y7fewk	95	25	respectively	respectively	RB
cord-257027-q2y7fewk	95	26	.	.	.
cord-257027-q2y7fewk	96	1	The	the	DT
cord-257027-q2y7fewk	96	2	first	first	JJ
cord-257027-q2y7fewk	96	3	genome	genome	NN
cord-257027-q2y7fewk	96	4	-	-	HYPH
cord-257027-q2y7fewk	96	5	wide	wide	JJ
cord-257027-q2y7fewk	96	6	association	association	NN
cord-257027-q2y7fewk	96	7	study	study	NN
cord-257027-q2y7fewk	96	8	in	in	IN
cord-257027-q2y7fewk	96	9	infectious	infectious	JJ
cord-257027-q2y7fewk	96	10	disease	disease	NN
cord-257027-q2y7fewk	96	11	was	be	VBD
cord-257027-q2y7fewk	96	12	published	publish	VBN
cord-257027-q2y7fewk	96	13	by	by	IN
cord-257027-q2y7fewk	96	14	Fellay	Fellay	NNP
cord-257027-q2y7fewk	96	15	et	et	NNP
cord-257027-q2y7fewk	96	16	al	al	NNP
cord-257027-q2y7fewk	96	17	.	.	.
cord-257027-q2y7fewk	97	1	(	(	-LRB-
cord-257027-q2y7fewk	97	2	40	40	CD
cord-257027-q2y7fewk	97	3	)	)	-RRB-
cord-257027-q2y7fewk	97	4	,	,	,
cord-257027-q2y7fewk	97	5	who	who	WP
cord-257027-q2y7fewk	97	6	found	find	VBD
cord-257027-q2y7fewk	97	7	an	an	DT
cord-257027-q2y7fewk	97	8	association	association	NN
cord-257027-q2y7fewk	97	9	of	of	IN
cord-257027-q2y7fewk	97	10	HLA	HLA	NNP
cord-257027-q2y7fewk	97	11	-	-	HYPH
cord-257027-q2y7fewk	97	12	B	B	NNP
cord-257027-q2y7fewk	97	13	and	and	CC
cord-257027-q2y7fewk	97	14	HLA	HLA	NNP
cord-257027-q2y7fewk	97	15	-	-	HYPH
cord-257027-q2y7fewk	97	16	C	C	NNP
cord-257027-q2y7fewk	97	17	with	with	IN
cord-257027-q2y7fewk	97	18	HIV	HIV	NNP
cord-257027-q2y7fewk	97	19	virus	virus	NN
cord-257027-q2y7fewk	97	20	load	load	NN
cord-257027-q2y7fewk	97	21	,	,	,
cord-257027-q2y7fewk	97	22	and	and	CC
cord-257027-q2y7fewk	97	23	of	of	IN
cord-257027-q2y7fewk	97	24	RNF39	RNF39	NNP
cord-257027-q2y7fewk	97	25	and	and	CC
cord-257027-q2y7fewk	97	26	ZNRD1	znrd1	NN
cord-257027-q2y7fewk	97	27	with	with	IN
cord-257027-q2y7fewk	97	28	disease	disease	NN
cord-257027-q2y7fewk	97	29	progression	progression	NN
cord-257027-q2y7fewk	97	30	.	.	.
cord-257027-q2y7fewk	98	1	More	more	RBR
cord-257027-q2y7fewk	98	2	recently	recently	RB
cord-257027-q2y7fewk	98	3	,	,	,
cord-257027-q2y7fewk	98	4	several	several	JJ
cord-257027-q2y7fewk	98	5	genome	genome	NN
cord-257027-q2y7fewk	98	6	-	-	HYPH
cord-257027-q2y7fewk	98	7	wide	wide	JJ
cord-257027-q2y7fewk	98	8	association	association	NN
cord-257027-q2y7fewk	98	9	studies	study	NNS
cord-257027-q2y7fewk	98	10	have	have	VBP
cord-257027-q2y7fewk	98	11	been	be	VBN
cord-257027-q2y7fewk	98	12	published	publish	VBN
cord-257027-q2y7fewk	98	13	for	for	IN
cord-257027-q2y7fewk	98	14	malaria	malaria	NN
cord-257027-q2y7fewk	98	15	,	,	,
cord-257027-q2y7fewk	98	16	hepatitis	hepatitis	NNP
cord-257027-q2y7fewk	98	17	B	B	NNP
cord-257027-q2y7fewk	98	18	,	,	,
cord-257027-q2y7fewk	98	19	and	and	CC
cord-257027-q2y7fewk	98	20	hepatitis	hepatitis	NN
cord-257027-q2y7fewk	98	21	C.	C.	NNP
cord-257027-q2y7fewk	99	1	The	the	DT
cord-257027-q2y7fewk	99	2	best	good	JJS
cord-257027-q2y7fewk	99	3	signals	signal	NNS
cord-257027-q2y7fewk	99	4	of	of	IN
cord-257027-q2y7fewk	99	5	association	association	NN
cord-257027-q2y7fewk	99	6	were	be	VBD
cord-257027-q2y7fewk	99	7	found	find	VBN
cord-257027-q2y7fewk	99	8	at	at	IN
cord-257027-q2y7fewk	99	9	the	the	DT
cord-257027-q2y7fewk	99	10	HBB	HBB	NNP
cord-257027-q2y7fewk	99	11	locus	locus	NN
cord-257027-q2y7fewk	99	12	for	for	IN
cord-257027-q2y7fewk	99	13	severe	severe	JJ
cord-257027-q2y7fewk	99	14	malaria	malaria	NN
cord-257027-q2y7fewk	99	15	(	(	-LRB-
cord-257027-q2y7fewk	99	16	35	35	CD
cord-257027-q2y7fewk	99	17	)	)	-RRB-
cord-257027-q2y7fewk	99	18	,	,	,
cord-257027-q2y7fewk	99	19	at	at	IN
cord-257027-q2y7fewk	99	20	the	the	DT
cord-257027-q2y7fewk	99	21	HLA	HLA	NNP
cord-257027-q2y7fewk	99	22	-	-	HYPH
cord-257027-q2y7fewk	99	23	DP	dp	NN
cord-257027-q2y7fewk	99	24	locus	locus	NN
cord-257027-q2y7fewk	99	25	for	for	IN
cord-257027-q2y7fewk	99	26	hepatitis	hepatitis	NN
cord-257027-q2y7fewk	99	27	B	B	NNP
cord-257027-q2y7fewk	99	28	(	(	-LRB-
cord-257027-q2y7fewk	99	29	41	41	CD
cord-257027-q2y7fewk	99	30	)	)	-RRB-
cord-257027-q2y7fewk	99	31	,	,	,
cord-257027-q2y7fewk	99	32	and	and	CC
cord-257027-q2y7fewk	99	33	at	at	IN
cord-257027-q2y7fewk	99	34	the	the	DT
cord-257027-q2y7fewk	99	35	IL28B	il28b	NN
cord-257027-q2y7fewk	99	36	locus	locus	NN
cord-257027-q2y7fewk	99	37	for	for	IN
cord-257027-q2y7fewk	99	38	hepatitis	hepatitis	NN
cord-257027-q2y7fewk	99	39	C	C	NNP
cord-257027-q2y7fewk	99	40	(	(	-LRB-
cord-257027-q2y7fewk	99	41	42	42	CD
cord-257027-q2y7fewk	99	42	,	,	,
cord-257027-q2y7fewk	99	43	43	43	CD
cord-257027-q2y7fewk	99	44	)	)	-RRB-
cord-257027-q2y7fewk	99	45	.	.	.
cord-257027-q2y7fewk	100	1	All	all	PDT
cord-257027-q2y7fewk	100	2	the	the	DT
cord-257027-q2y7fewk	100	3	studies	study	NNS
cord-257027-q2y7fewk	100	4	were	be	VBD
cord-257027-q2y7fewk	100	5	based	base	VBN
cord-257027-q2y7fewk	100	6	on	on	IN
cord-257027-q2y7fewk	100	7	single	single	JJ
cord-257027-q2y7fewk	100	8	nucleotide	nucleotide	JJ
cord-257027-q2y7fewk	100	9	polymorphism	polymorphism	NN
cord-257027-q2y7fewk	100	10	(	(	-LRB-
cord-257027-q2y7fewk	100	11	SNP	SNP	NNP
cord-257027-q2y7fewk	100	12	)	)	-RRB-
cord-257027-q2y7fewk	100	13	arrays	array	NNS
cord-257027-q2y7fewk	100	14	:	:	:
cord-257027-q2y7fewk	101	1	500,000	500,000	CD
cord-257027-q2y7fewk	101	2	SNPs	SNPs	NNPS
cord-257027-q2y7fewk	101	3	were	be	VBD
cord-257027-q2y7fewk	101	4	genotyped	genotype	VBN
cord-257027-q2y7fewk	101	5	in	in	IN
cord-257027-q2y7fewk	101	6	the	the	DT
cord-257027-q2y7fewk	101	7	HIV	HIV	NNP
cord-257027-q2y7fewk	101	8	,	,	,
cord-257027-q2y7fewk	101	9	malaria	malaria	NN
cord-257027-q2y7fewk	101	10	,	,	,
cord-257027-q2y7fewk	101	11	and	and	CC
cord-257027-q2y7fewk	101	12	hepatitis	hepatitis	NNP
cord-257027-q2y7fewk	101	13	B	B	NNP
cord-257027-q2y7fewk	101	14	studies	study	NNS
cord-257027-q2y7fewk	101	15	,	,	,
cord-257027-q2y7fewk	101	16	while	while	IN
cord-257027-q2y7fewk	101	17	900,000	900,000	CD
cord-257027-q2y7fewk	101	18	SNPs	snp	NNS
cord-257027-q2y7fewk	101	19	were	be	VBD
cord-257027-q2y7fewk	101	20	analyzed	analyze	VBN
cord-257027-q2y7fewk	101	21	in	in	IN
cord-257027-q2y7fewk	101	22	the	the	DT
cord-257027-q2y7fewk	101	23	hepatitis	hepatitis	NN
cord-257027-q2y7fewk	101	24	C	C	NNP
cord-257027-q2y7fewk	101	25	study	study	NN
cord-257027-q2y7fewk	101	26	.	.	.
cord-257027-q2y7fewk	102	1	Twin	twin	JJ
cord-257027-q2y7fewk	102	2	studies	study	NNS
cord-257027-q2y7fewk	102	3	have	have	VBP
cord-257027-q2y7fewk	102	4	recently	recently	RB
cord-257027-q2y7fewk	102	5	established	establish	VBN
cord-257027-q2y7fewk	102	6	that	that	IN
cord-257027-q2y7fewk	102	7	genetic	genetic	JJ
cord-257027-q2y7fewk	102	8	variation	variation	NN
cord-257027-q2y7fewk	102	9	influences	influence	VBZ
cord-257027-q2y7fewk	102	10	the	the	DT
cord-257027-q2y7fewk	102	11	response	response	NN
cord-257027-q2y7fewk	102	12	to	to	TO
cord-257027-q2y7fewk	102	13	hepatitis	hepatitis	VB
cord-257027-q2y7fewk	102	14	A	A	NNP
cord-257027-q2y7fewk	102	15	and	and	CC
cord-257027-q2y7fewk	102	16	B	b	NN
cord-257027-q2y7fewk	102	17	,	,	,
cord-257027-q2y7fewk	102	18	diphtheria	diphtheria	NN
cord-257027-q2y7fewk	102	19	,	,	,
cord-257027-q2y7fewk	102	20	tetanus	tetanus	NN
cord-257027-q2y7fewk	102	21	,	,	,
cord-257027-q2y7fewk	102	22	measles	measle	NNS
cord-257027-q2y7fewk	102	23	,	,	,
cord-257027-q2y7fewk	102	24	mumps	mumps	NN
cord-257027-q2y7fewk	102	25	,	,	,
cord-257027-q2y7fewk	102	26	rubella	rubella	NN
cord-257027-q2y7fewk	102	27	,	,	,
cord-257027-q2y7fewk	102	28	polio	polio	NN
cord-257027-q2y7fewk	102	29	,	,	,
cord-257027-q2y7fewk	102	30	H.	H.	NNP
cord-257027-q2y7fewk	102	31	influenzae	influenzae	NN
cord-257027-q2y7fewk	102	32	type	type	NN
cord-257027-q2y7fewk	102	33	b	b	NN
cord-257027-q2y7fewk	102	34	,	,	,
cord-257027-q2y7fewk	102	35	pertussis	pertussis	NN
cord-257027-q2y7fewk	102	36	,	,	,
cord-257027-q2y7fewk	102	37	and	and	CC
cord-257027-q2y7fewk	102	38	BCG	BCG	NNP
cord-257027-q2y7fewk	102	39	vaccines	vaccine	NNS
cord-257027-q2y7fewk	102	40	(	(	-LRB-
cord-257027-q2y7fewk	102	41	44	44	CD
cord-257027-q2y7fewk	102	42	)	)	-RRB-
cord-257027-q2y7fewk	102	43	.	.	.
cord-257027-q2y7fewk	103	1	Such	such	JJ
cord-257027-q2y7fewk	103	2	studies	study	NNS
cord-257027-q2y7fewk	103	3	have	have	VBP
cord-257027-q2y7fewk	103	4	led	lead	VBN
cord-257027-q2y7fewk	103	5	to	to	TO
cord-257027-q2y7fewk	103	6	estimate	estimate	VB
cord-257027-q2y7fewk	103	7	the	the	DT
cord-257027-q2y7fewk	103	8	heritability	heritability	NN
cord-257027-q2y7fewk	103	9	,	,	,
cord-257027-q2y7fewk	103	10	defined	define	VBN
cord-257027-q2y7fewk	103	11	as	as	IN
cord-257027-q2y7fewk	103	12	the	the	DT
cord-257027-q2y7fewk	103	13	ratio	ratio	NN
cord-257027-q2y7fewk	103	14	of	of	IN
cord-257027-q2y7fewk	103	15	genetic	genetic	JJ
cord-257027-q2y7fewk	103	16	variance	variance	NN
cord-257027-q2y7fewk	103	17	to	to	IN
cord-257027-q2y7fewk	103	18	total	total	JJ
cord-257027-q2y7fewk	103	19	variance	variance	NN
cord-257027-q2y7fewk	103	20	,	,	,
cord-257027-q2y7fewk	103	21	of	of	IN
cord-257027-q2y7fewk	103	22	immune	immune	JJ
cord-257027-q2y7fewk	103	23	responses	response	NNS
cord-257027-q2y7fewk	103	24	(	(	-LRB-
cord-257027-q2y7fewk	103	25	14	14	CD
cord-257027-q2y7fewk	103	26	)	)	-RRB-
cord-257027-q2y7fewk	103	27	.	.	.
cord-257027-q2y7fewk	104	1	Early	early	JJ
cord-257027-q2y7fewk	104	2	papers	paper	NNS
cord-257027-q2y7fewk	104	3	have	have	VBP
cord-257027-q2y7fewk	104	4	reported	report	VBN
cord-257027-q2y7fewk	104	5	a	a	DT
cord-257027-q2y7fewk	104	6	heritability	heritability	NN
cord-257027-q2y7fewk	104	7	of	of	IN
cord-257027-q2y7fewk	104	8	61	61	CD
cord-257027-q2y7fewk	104	9	and	and	CC
cord-257027-q2y7fewk	104	10	77	77	CD
cord-257027-q2y7fewk	104	11	%	%	NN
cord-257027-q2y7fewk	104	12	for	for	IN
cord-257027-q2y7fewk	104	13	the	the	DT
cord-257027-q2y7fewk	104	14	antibody	antibody	NN
cord-257027-q2y7fewk	104	15	response	response	NN
cord-257027-q2y7fewk	104	16	to	to	IN
cord-257027-q2y7fewk	104	17	the	the	DT
cord-257027-q2y7fewk	104	18	hepatitis	hepatitis	NN
cord-257027-q2y7fewk	104	19	B	B	NNP
cord-257027-q2y7fewk	104	20	surface	surface	NN
cord-257027-q2y7fewk	104	21	antigen	antigen	NN
cord-257027-q2y7fewk	104	22	vaccine	vaccine	NN
cord-257027-q2y7fewk	104	23	in	in	IN
cord-257027-q2y7fewk	104	24	adults	adult	NNS
cord-257027-q2y7fewk	104	25	(	(	-LRB-
cord-257027-q2y7fewk	104	26	45	45	CD
cord-257027-q2y7fewk	104	27	)	)	-RRB-
cord-257027-q2y7fewk	104	28	and	and	CC
cord-257027-q2y7fewk	104	29	young	young	JJ
cord-257027-q2y7fewk	104	30	children	child	NNS
cord-257027-q2y7fewk	104	31	(	(	-LRB-
cord-257027-q2y7fewk	104	32	46	46	CD
cord-257027-q2y7fewk	104	33	)	)	-RRB-
cord-257027-q2y7fewk	104	34	,	,	,
cord-257027-q2y7fewk	104	35	respectively	respectively	RB
cord-257027-q2y7fewk	104	36	;	;	:
cord-257027-q2y7fewk	104	37	it	-PRON-	PRP
cord-257027-q2y7fewk	104	38	should	should	MD
cord-257027-q2y7fewk	104	39	be	be	VB
cord-257027-q2y7fewk	104	40	stressed	stress	VBN
cord-257027-q2y7fewk	104	41	that	that	IN
cord-257027-q2y7fewk	104	42	high	high	JJ
cord-257027-q2y7fewk	104	43	levels	level	NNS
cord-257027-q2y7fewk	104	44	of	of	IN
cord-257027-q2y7fewk	104	45	antibody	antibody	NN
cord-257027-q2y7fewk	104	46	against	against	IN
cord-257027-q2y7fewk	104	47	hepatitis	hepatitis	NNP
cord-257027-q2y7fewk	104	48	B	B	NNP
cord-257027-q2y7fewk	104	49	surface	surface	NN
cord-257027-q2y7fewk	104	50	antigen	antigen	NN
cord-257027-q2y7fewk	104	51	correlate	correlate	VBP
cord-257027-q2y7fewk	104	52	with	with	IN
cord-257027-q2y7fewk	104	53	protection	protection	NN
cord-257027-q2y7fewk	104	54	against	against	IN
cord-257027-q2y7fewk	104	55	infection	infection	NN
cord-257027-q2y7fewk	104	56	and	and	CC
cord-257027-q2y7fewk	104	57	persistent	persistent	JJ
cord-257027-q2y7fewk	104	58	carriage	carriage	NN
cord-257027-q2y7fewk	104	59	(	(	-LRB-
cord-257027-q2y7fewk	104	60	47	47	CD
cord-257027-q2y7fewk	104	61	)	)	-RRB-
cord-257027-q2y7fewk	104	62	.	.	.
cord-257027-q2y7fewk	105	1	The	the	DT
cord-257027-q2y7fewk	105	2	heritability	heritability	NN
cord-257027-q2y7fewk	105	3	of	of	IN
cord-257027-q2y7fewk	105	4	vaccine	vaccine	NN
cord-257027-q2y7fewk	105	5	responses	response	NNS
cord-257027-q2y7fewk	105	6	is	be	VBZ
cord-257027-q2y7fewk	105	7	generally	generally	RB
cord-257027-q2y7fewk	105	8	high	high	JJ
cord-257027-q2y7fewk	105	9	(	(	-LRB-
cord-257027-q2y7fewk	105	10	44	44	CD
cord-257027-q2y7fewk	105	11	)	)	-RRB-
cord-257027-q2y7fewk	105	12	,	,	,
cord-257027-q2y7fewk	105	13	reaching	reach	VBG
cord-257027-q2y7fewk	105	14	89	89	CD
cord-257027-q2y7fewk	105	15	%	%	NN
cord-257027-q2y7fewk	105	16	for	for	IN
cord-257027-q2y7fewk	105	17	the	the	DT
cord-257027-q2y7fewk	105	18	antibody	antibody	NN
cord-257027-q2y7fewk	105	19	response	response	NN
cord-257027-q2y7fewk	105	20	against	against	IN
cord-257027-q2y7fewk	105	21	measles	measles	NNP
cord-257027-q2y7fewk	105	22	vaccine	vaccine	NN
cord-257027-q2y7fewk	105	23	(	(	-LRB-
cord-257027-q2y7fewk	105	24	16	16	CD
cord-257027-q2y7fewk	105	25	)	)	-RRB-
cord-257027-q2y7fewk	105	26	.	.	.
cord-257027-q2y7fewk	106	1	It	-PRON-	PRP
cord-257027-q2y7fewk	106	2	should	should	MD
cord-257027-q2y7fewk	106	3	be	be	VB
cord-257027-q2y7fewk	106	4	stressed	stress	VBN
cord-257027-q2y7fewk	106	5	that	that	IN
cord-257027-q2y7fewk	106	6	the	the	DT
cord-257027-q2y7fewk	106	7	immune	immune	JJ
cord-257027-q2y7fewk	106	8	mechanisms	mechanism	NNS
cord-257027-q2y7fewk	106	9	responsible	responsible	JJ
cord-257027-q2y7fewk	106	10	for	for	IN
cord-257027-q2y7fewk	106	11	protection	protection	NN
cord-257027-q2y7fewk	106	12	are	be	VBP
cord-257027-q2y7fewk	106	13	largely	largely	RB
cord-257027-q2y7fewk	106	14	unknown	unknown	JJ
cord-257027-q2y7fewk	106	15	for	for	IN
cord-257027-q2y7fewk	106	16	a	a	DT
cord-257027-q2y7fewk	106	17	variety	variety	NN
cord-257027-q2y7fewk	106	18	of	of	IN
cord-257027-q2y7fewk	106	19	infectious	infectious	JJ
cord-257027-q2y7fewk	106	20	diseases	disease	NNS
cord-257027-q2y7fewk	106	21	.	.	.
cord-257027-q2y7fewk	107	1	Also	also	RB
cord-257027-q2y7fewk	107	2	immunological	immunological	JJ
cord-257027-q2y7fewk	107	3	correlates	correlate	NNS
cord-257027-q2y7fewk	107	4	of	of	IN
cord-257027-q2y7fewk	107	5	protection	protection	NN
cord-257027-q2y7fewk	107	6	are	be	VBP
cord-257027-q2y7fewk	107	7	needed	need	VBN
cord-257027-q2y7fewk	107	8	to	to	TO
cord-257027-q2y7fewk	107	9	monitor	monitor	VB
cord-257027-q2y7fewk	107	10	the	the	DT
cord-257027-q2y7fewk	107	11	efficacy	efficacy	NN
cord-257027-q2y7fewk	107	12	of	of	IN
cord-257027-q2y7fewk	107	13	vaccines	vaccine	NNS
cord-257027-q2y7fewk	107	14	and	and	CC
cord-257027-q2y7fewk	107	15	to	to	TO
cord-257027-q2y7fewk	107	16	study	study	VB
cord-257027-q2y7fewk	107	17	the	the	DT
cord-257027-q2y7fewk	107	18	genetics	genetic	NNS
cord-257027-q2y7fewk	107	19	of	of	IN
cord-257027-q2y7fewk	107	20	protective	protective	JJ
cord-257027-q2y7fewk	107	21	responses	response	NNS
cord-257027-q2y7fewk	107	22	to	to	IN
cord-257027-q2y7fewk	107	23	vaccines	vaccine	NNS
cord-257027-q2y7fewk	107	24	(	(	-LRB-
cord-257027-q2y7fewk	107	25	48	48	CD
cord-257027-q2y7fewk	107	26	)	)	-RRB-
cord-257027-q2y7fewk	107	27	.	.	.
cord-257027-q2y7fewk	108	1	The	the	DT
cord-257027-q2y7fewk	108	2	influence	influence	NN
cord-257027-q2y7fewk	108	3	of	of	IN
cord-257027-q2y7fewk	108	4	the	the	DT
cord-257027-q2y7fewk	108	5	genetic	genetic	JJ
cord-257027-q2y7fewk	108	6	background	background	NN
cord-257027-q2y7fewk	108	7	has	have	VBZ
cord-257027-q2y7fewk	108	8	been	be	VBN
cord-257027-q2y7fewk	108	9	further	further	RB
cord-257027-q2y7fewk	108	10	supported	support	VBN
cord-257027-q2y7fewk	108	11	by	by	IN
cord-257027-q2y7fewk	108	12	twin	twin	NN
cord-257027-q2y7fewk	108	13	-	-	HYPH
cord-257027-q2y7fewk	108	14	based	base	VBN
cord-257027-q2y7fewk	108	15	and	and	CC
cord-257027-q2y7fewk	108	16	population	population	NN
cord-257027-q2y7fewk	108	17	-	-	HYPH
cord-257027-q2y7fewk	108	18	based	base	VBN
cord-257027-q2y7fewk	108	19	association	association	NN
cord-257027-q2y7fewk	108	20	studies	study	NNS
cord-257027-q2y7fewk	108	21	,	,	,
cord-257027-q2y7fewk	108	22	which	which	WDT
cord-257027-q2y7fewk	108	23	have	have	VBP
cord-257027-q2y7fewk	108	24	revealed	reveal	VBN
cord-257027-q2y7fewk	108	25	the	the	DT
cord-257027-q2y7fewk	108	26	association	association	NN
cord-257027-q2y7fewk	108	27	of	of	IN
cord-257027-q2y7fewk	108	28	HLA	HLA	NNP
cord-257027-q2y7fewk	108	29	and	and	CC
cord-257027-q2y7fewk	108	30	non	non	JJ
cord-257027-q2y7fewk	108	31	-	-	JJ
cord-257027-q2y7fewk	108	32	HLA	HLA	NNP
cord-257027-q2y7fewk	108	33	candidate	candidate	NN
cord-257027-q2y7fewk	108	34	genes	gene	NNS
cord-257027-q2y7fewk	108	35	with	with	IN
cord-257027-q2y7fewk	108	36	the	the	DT
cord-257027-q2y7fewk	108	37	response	response	NN
cord-257027-q2y7fewk	108	38	to	to	TO
cord-257027-q2y7fewk	108	39	hepatitis	hepatitis	VB
cord-257027-q2y7fewk	108	40	A	A	NNP
cord-257027-q2y7fewk	108	41	and	and	CC
cord-257027-q2y7fewk	108	42	B	b	NN
cord-257027-q2y7fewk	108	43	,	,	,
cord-257027-q2y7fewk	108	44	influenza	influenza	NN
cord-257027-q2y7fewk	108	45	,	,	,
cord-257027-q2y7fewk	108	46	measles	measle	NNS
cord-257027-q2y7fewk	108	47	,	,	,
cord-257027-q2y7fewk	108	48	rubella	rubella	NN
cord-257027-q2y7fewk	108	49	,	,	,
cord-257027-q2y7fewk	108	50	and	and	CC
cord-257027-q2y7fewk	108	51	BCG	BCG	NNP
cord-257027-q2y7fewk	108	52	vaccines	vaccine	NNS
cord-257027-q2y7fewk	108	53	(	(	-LRB-
cord-257027-q2y7fewk	108	54	44	44	CD
cord-257027-q2y7fewk	108	55	,	,	,
cord-257027-q2y7fewk	108	56	49	49	CD
cord-257027-q2y7fewk	108	57	)	)	-RRB-
cord-257027-q2y7fewk	108	58	.	.	.
cord-257027-q2y7fewk	109	1	However	however	RB
cord-257027-q2y7fewk	109	2	,	,	,
cord-257027-q2y7fewk	109	3	few	few	JJ
cord-257027-q2y7fewk	109	4	candidates	candidate	NNS
cord-257027-q2y7fewk	109	5	have	have	VBP
cord-257027-q2y7fewk	109	6	been	be	VBN
cord-257027-q2y7fewk	109	7	simultaneously	simultaneously	RB
cord-257027-q2y7fewk	109	8	tested	test	VBN
cord-257027-q2y7fewk	109	9	by	by	IN
cord-257027-q2y7fewk	109	10	each	each	DT
cord-257027-q2y7fewk	109	11	research	research	NN
cord-257027-q2y7fewk	109	12	group	group	NN
cord-257027-q2y7fewk	109	13	,	,	,
cord-257027-q2y7fewk	109	14	except	except	IN
cord-257027-q2y7fewk	109	15	for	for	IN
cord-257027-q2y7fewk	109	16	the	the	DT
cord-257027-q2y7fewk	109	17	study	study	NN
cord-257027-q2y7fewk	109	18	by	by	IN
cord-257027-q2y7fewk	109	19	Hennig	Hennig	NNP
cord-257027-q2y7fewk	109	20	et	et	NNP
cord-257027-q2y7fewk	109	21	al	al	NNP
cord-257027-q2y7fewk	109	22	.	.	.
cord-257027-q2y7fewk	110	1	(	(	-LRB-
cord-257027-q2y7fewk	110	2	47	47	CD
cord-257027-q2y7fewk	110	3	)	)	-RRB-
cord-257027-q2y7fewk	110	4	,	,	,
cord-257027-q2y7fewk	110	5	who	who	WP
cord-257027-q2y7fewk	110	6	analyzed	analyze	VBD
cord-257027-q2y7fewk	110	7	133	133	CD
cord-257027-q2y7fewk	110	8	candidate	candidate	NN
cord-257027-q2y7fewk	110	9	genes	gene	NNS
cord-257027-q2y7fewk	110	10	.	.	.
cord-257027-q2y7fewk	111	1	It	-PRON-	PRP
cord-257027-q2y7fewk	111	2	is	be	VBZ
cord-257027-q2y7fewk	111	3	likely	likely	JJ
cord-257027-q2y7fewk	111	4	that	that	IN
cord-257027-q2y7fewk	111	5	there	there	EX
cord-257027-q2y7fewk	111	6	are	be	VBP
cord-257027-q2y7fewk	111	7	genes	gene	NNS
cord-257027-q2y7fewk	111	8	involved	involve	VBN
cord-257027-q2y7fewk	111	9	in	in	IN
cord-257027-q2y7fewk	111	10	both	both	DT
cord-257027-q2y7fewk	111	11	resistance	resistance	NN
cord-257027-q2y7fewk	111	12	to	to	IN
cord-257027-q2y7fewk	111	13	a	a	DT
cord-257027-q2y7fewk	111	14	particular	particular	JJ
cord-257027-q2y7fewk	111	15	infectious	infectious	JJ
cord-257027-q2y7fewk	111	16	disease	disease	NN
cord-257027-q2y7fewk	111	17	and	and	CC
cord-257027-q2y7fewk	111	18	response	response	NN
cord-257027-q2y7fewk	111	19	to	to	IN
cord-257027-q2y7fewk	111	20	the	the	DT
cord-257027-q2y7fewk	111	21	corresponding	correspond	VBG
cord-257027-q2y7fewk	111	22	candidate	candidate	NN
cord-257027-q2y7fewk	111	23	vaccines	vaccine	NNS
cord-257027-q2y7fewk	111	24	.	.	.
cord-257027-q2y7fewk	112	1	Therefore	therefore	RB
cord-257027-q2y7fewk	112	2	,	,	,
cord-257027-q2y7fewk	112	3	genes	gene	NNS
cord-257027-q2y7fewk	112	4	that	that	WDT
cord-257027-q2y7fewk	112	5	have	have	VBP
cord-257027-q2y7fewk	112	6	been	be	VBN
cord-257027-q2y7fewk	112	7	associated	associate	VBN
cord-257027-q2y7fewk	112	8	with	with	IN
cord-257027-q2y7fewk	112	9	resistance	resistance	NN
cord-257027-q2y7fewk	112	10	or	or	CC
cord-257027-q2y7fewk	112	11	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	112	12	to	to	IN
cord-257027-q2y7fewk	112	13	infection	infection	NN
cord-257027-q2y7fewk	112	14	or	or	CC
cord-257027-q2y7fewk	112	15	disease	disease	NN
cord-257027-q2y7fewk	112	16	can	can	MD
cord-257027-q2y7fewk	112	17	be	be	VB
cord-257027-q2y7fewk	112	18	considered	consider	VBN
cord-257027-q2y7fewk	112	19	candidates	candidate	NNS
cord-257027-q2y7fewk	112	20	potentially	potentially	RB
cord-257027-q2y7fewk	112	21	involved	involved	JJ
cord-257027-q2y7fewk	112	22	in	in	IN
cord-257027-q2y7fewk	112	23	the	the	DT
cord-257027-q2y7fewk	112	24	response	response	NN
cord-257027-q2y7fewk	112	25	to	to	IN
cord-257027-q2y7fewk	112	26	the	the	DT
cord-257027-q2y7fewk	112	27	vaccine	vaccine	NN
cord-257027-q2y7fewk	112	28	.	.	.
cord-257027-q2y7fewk	113	1	The	the	DT
cord-257027-q2y7fewk	113	2	genes	gene	NNS
cord-257027-q2y7fewk	113	3	that	that	WDT
cord-257027-q2y7fewk	113	4	will	will	MD
cord-257027-q2y7fewk	113	5	be	be	VB
cord-257027-q2y7fewk	113	6	identified	identify	VBN
cord-257027-q2y7fewk	113	7	through	through	IN
cord-257027-q2y7fewk	113	8	genome	genome	NN
cord-257027-q2y7fewk	113	9	-	-	HYPH
cord-257027-q2y7fewk	113	10	wide	wide	JJ
cord-257027-q2y7fewk	113	11	approaches	approach	NNS
cord-257027-q2y7fewk	113	12	in	in	IN
cord-257027-q2y7fewk	113	13	infectious	infectious	JJ
cord-257027-q2y7fewk	113	14	diseases	disease	NNS
cord-257027-q2y7fewk	113	15	will	will	MD
cord-257027-q2y7fewk	113	16	be	be	VB
cord-257027-q2y7fewk	113	17	of	of	IN
cord-257027-q2y7fewk	113	18	particular	particular	JJ
cord-257027-q2y7fewk	113	19	interest	interest	NN
cord-257027-q2y7fewk	113	20	;	;	:
cord-257027-q2y7fewk	113	21	conversely	conversely	RB
cord-257027-q2y7fewk	113	22	,	,	,
cord-257027-q2y7fewk	113	23	the	the	DT
cord-257027-q2y7fewk	113	24	genes	gene	NNS
cord-257027-q2y7fewk	113	25	that	that	WDT
cord-257027-q2y7fewk	113	26	affect	affect	VBP
cord-257027-q2y7fewk	113	27	the	the	DT
cord-257027-q2y7fewk	113	28	response	response	NN
cord-257027-q2y7fewk	113	29	to	to	IN
cord-257027-q2y7fewk	113	30	vaccination	vaccination	NN
cord-257027-q2y7fewk	113	31	may	may	MD
cord-257027-q2y7fewk	113	32	be	be	VB
cord-257027-q2y7fewk	113	33	analyzed	analyze	VBN
cord-257027-q2y7fewk	113	34	for	for	IN
cord-257027-q2y7fewk	113	35	their	-PRON-	PRP$
cord-257027-q2y7fewk	113	36	potential	potential	JJ
cord-257027-q2y7fewk	113	37	role	role	NN
cord-257027-q2y7fewk	113	38	in	in	IN
cord-257027-q2y7fewk	113	39	resistance	resistance	NN
cord-257027-q2y7fewk	113	40	or	or	CC
cord-257027-q2y7fewk	113	41	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	113	42	to	to	IN
cord-257027-q2y7fewk	113	43	the	the	DT
cord-257027-q2y7fewk	113	44	corresponding	correspond	VBG
cord-257027-q2y7fewk	113	45	disease	disease	NN
cord-257027-q2y7fewk	113	46	.	.	.
cord-257027-q2y7fewk	114	1	It	-PRON-	PRP
cord-257027-q2y7fewk	114	2	may	may	MD
cord-257027-q2y7fewk	114	3	be	be	VB
cord-257027-q2y7fewk	114	4	the	the	DT
cord-257027-q2y7fewk	114	5	time	time	NN
cord-257027-q2y7fewk	114	6	to	to	TO
cord-257027-q2y7fewk	114	7	move	move	VB
cord-257027-q2y7fewk	114	8	from	from	IN
cord-257027-q2y7fewk	114	9	the	the	DT
cord-257027-q2y7fewk	114	10	candidate	candidate	NN
cord-257027-q2y7fewk	114	11	gene	gene	NN
cord-257027-q2y7fewk	114	12	approach	approach	NN
cord-257027-q2y7fewk	114	13	to	to	IN
cord-257027-q2y7fewk	114	14	genome	genome	NN
cord-257027-q2y7fewk	114	15	-	-	HYPH
cord-257027-q2y7fewk	114	16	wide	wide	JJ
cord-257027-q2y7fewk	114	17	linkage	linkage	NN
cord-257027-q2y7fewk	115	1	and/or	and/or	CC
cord-257027-q2y7fewk	115	2	association	association	NN
cord-257027-q2y7fewk	115	3	approaches	approach	NNS
cord-257027-q2y7fewk	115	4	in	in	IN
cord-257027-q2y7fewk	115	5	order	order	NN
cord-257027-q2y7fewk	115	6	to	to	TO
cord-257027-q2y7fewk	115	7	identify	identify	VB
cord-257027-q2y7fewk	115	8	genes	gene	NNS
cord-257027-q2y7fewk	115	9	controlling	control	VBG
cord-257027-q2y7fewk	115	10	the	the	DT
cord-257027-q2y7fewk	115	11	response	response	NN
cord-257027-q2y7fewk	115	12	to	to	IN
cord-257027-q2y7fewk	115	13	vaccination	vaccination	NN
cord-257027-q2y7fewk	115	14	(	(	-LRB-
cord-257027-q2y7fewk	115	15	Figure	figure	NN
cord-257027-q2y7fewk	115	16	1	1	CD
cord-257027-q2y7fewk	115	17	)	)	-RRB-
cord-257027-q2y7fewk	115	18	.	.	.
cord-257027-q2y7fewk	116	1	It	-PRON-	PRP
cord-257027-q2y7fewk	116	2	is	be	VBZ
cord-257027-q2y7fewk	116	3	very	very	RB
cord-257027-q2y7fewk	116	4	likely	likely	JJ
cord-257027-q2y7fewk	116	5	that	that	IN
cord-257027-q2y7fewk	116	6	populations	population	NNS
cord-257027-q2y7fewk	116	7	with	with	IN
cord-257027-q2y7fewk	116	8	different	different	JJ
cord-257027-q2y7fewk	116	9	genetic	genetic	JJ
cord-257027-q2y7fewk	116	10	backgrounds	background	NNS
cord-257027-q2y7fewk	116	11	will	will	MD
cord-257027-q2y7fewk	116	12	differ	differ	VB
cord-257027-q2y7fewk	116	13	in	in	IN
cord-257027-q2y7fewk	116	14	their	-PRON-	PRP$
cord-257027-q2y7fewk	116	15	genetic	genetic	JJ
cord-257027-q2y7fewk	116	16	control	control	NN
cord-257027-q2y7fewk	116	17	of	of	IN
cord-257027-q2y7fewk	116	18	infectious	infectious	JJ
cord-257027-q2y7fewk	116	19	diseases	disease	NNS
cord-257027-q2y7fewk	116	20	:	:	:
cord-257027-q2y7fewk	116	21	for	for	IN
cord-257027-q2y7fewk	116	22	a	a	DT
cord-257027-q2y7fewk	116	23	particular	particular	JJ
cord-257027-q2y7fewk	116	24	infectious	infectious	JJ
cord-257027-q2y7fewk	116	25	disease	disease	NN
cord-257027-q2y7fewk	116	26	,	,	,
cord-257027-q2y7fewk	116	27	the	the	DT
cord-257027-q2y7fewk	116	28	involvement	involvement	NN
cord-257027-q2y7fewk	116	29	of	of	IN
cord-257027-q2y7fewk	116	30	some	some	DT
cord-257027-q2y7fewk	116	31	loci	locus	NNS
cord-257027-q2y7fewk	116	32	may	may	MD
cord-257027-q2y7fewk	116	33	be	be	VB
cord-257027-q2y7fewk	116	34	evidenced	evidence	VBN
cord-257027-q2y7fewk	116	35	in	in	IN
cord-257027-q2y7fewk	116	36	a	a	DT
cord-257027-q2y7fewk	116	37	population	population	NN
cord-257027-q2y7fewk	116	38	living	live	VBG
cord-257027-q2y7fewk	116	39	in	in	IN
cord-257027-q2y7fewk	116	40	Africa	Africa	NNP
cord-257027-q2y7fewk	116	41	and	and	CC
cord-257027-q2y7fewk	116	42	may	may	MD
cord-257027-q2y7fewk	116	43	not	not	RB
cord-257027-q2y7fewk	116	44	be	be	VB
cord-257027-q2y7fewk	116	45	detected	detect	VBN
cord-257027-q2y7fewk	116	46	in	in	IN
cord-257027-q2y7fewk	116	47	another	another	DT
cord-257027-q2y7fewk	116	48	one	one	NN
cord-257027-q2y7fewk	116	49	living	live	VBG
cord-257027-q2y7fewk	116	50	in	in	IN
cord-257027-q2y7fewk	116	51	Asia	Asia	NNP
cord-257027-q2y7fewk	116	52	.	.	.
cord-257027-q2y7fewk	117	1	Ethnic	ethnic	JJ
cord-257027-q2y7fewk	117	2	groups	group	NNS
cord-257027-q2y7fewk	117	3	living	live	VBG
cord-257027-q2y7fewk	117	4	in	in	IN
cord-257027-q2y7fewk	117	5	the	the	DT
cord-257027-q2y7fewk	117	6	same	same	JJ
cord-257027-q2y7fewk	117	7	area	area	NN
cord-257027-q2y7fewk	117	8	can	can	MD
cord-257027-q2y7fewk	117	9	also	also	RB
cord-257027-q2y7fewk	117	10	differ	differ	VB
cord-257027-q2y7fewk	117	11	in	in	IN
cord-257027-q2y7fewk	117	12	their	-PRON-	PRP$
cord-257027-q2y7fewk	117	13	ability	ability	NN
cord-257027-q2y7fewk	117	14	to	to	TO
cord-257027-q2y7fewk	117	15	control	control	VB
cord-257027-q2y7fewk	117	16	infection	infection	NN
cord-257027-q2y7fewk	117	17	or	or	CC
cord-257027-q2y7fewk	117	18	disease	disease	NN
cord-257027-q2y7fewk	117	19	.	.	.
cord-257027-q2y7fewk	118	1	For	for	IN
cord-257027-q2y7fewk	118	2	example	example	NN
cord-257027-q2y7fewk	118	3	,	,	,
cord-257027-q2y7fewk	118	4	the	the	DT
cord-257027-q2y7fewk	118	5	Fulani	Fulani	NNP
cord-257027-q2y7fewk	118	6	,	,	,
cord-257027-q2y7fewk	118	7	whose	whose	WP$
cord-257027-q2y7fewk	118	8	genetic	genetic	JJ
cord-257027-q2y7fewk	118	9	background	background	NN
cord-257027-q2y7fewk	118	10	is	be	VBZ
cord-257027-q2y7fewk	118	11	clearly	clearly	RB
cord-257027-q2y7fewk	118	12	different	different	JJ
cord-257027-q2y7fewk	118	13	from	from	IN
cord-257027-q2y7fewk	118	14	that	that	DT
cord-257027-q2y7fewk	118	15	of	of	IN
cord-257027-q2y7fewk	118	16	other	other	JJ
cord-257027-q2y7fewk	118	17	ethnic	ethnic	JJ
cord-257027-q2y7fewk	118	18	groups	group	NNS
cord-257027-q2y7fewk	118	19	in	in	IN
cord-257027-q2y7fewk	118	20	West	West	NNP
cord-257027-q2y7fewk	118	21	Africa	Africa	NNP
cord-257027-q2y7fewk	118	22	,	,	,
cord-257027-q2y7fewk	118	23	have	have	VBP
cord-257027-q2y7fewk	118	24	been	be	VBN
cord-257027-q2y7fewk	118	25	compared	compare	VBN
cord-257027-q2y7fewk	118	26	to	to	IN
cord-257027-q2y7fewk	118	27	sympatric	sympatric	JJ
cord-257027-q2y7fewk	118	28	ethnic	ethnic	JJ
cord-257027-q2y7fewk	118	29	groups	group	NNS
cord-257027-q2y7fewk	118	30	for	for	IN
cord-257027-q2y7fewk	118	31	several	several	JJ
cord-257027-q2y7fewk	118	32	phenotypes	phenotype	NNS
cord-257027-q2y7fewk	118	33	related	relate	VBN
cord-257027-q2y7fewk	118	34	to	to	IN
cord-257027-q2y7fewk	118	35	malaria	malaria	NN
cord-257027-q2y7fewk	118	36	resistance	resistance	NN
cord-257027-q2y7fewk	118	37	.	.	.
cord-257027-q2y7fewk	119	1	The	the	DT
cord-257027-q2y7fewk	119	2	Fulani	Fulani	NNPS
cord-257027-q2y7fewk	119	3	produce	produce	VBP
cord-257027-q2y7fewk	119	4	higher	high	JJR
cord-257027-q2y7fewk	119	5	antibody	antibody	NN
cord-257027-q2y7fewk	119	6	levels	level	NNS
cord-257027-q2y7fewk	119	7	than	than	IN
cord-257027-q2y7fewk	119	8	the	the	DT
cord-257027-q2y7fewk	119	9	Mossi	Mossi	NNP
cord-257027-q2y7fewk	119	10	and	and	CC
cord-257027-q2y7fewk	119	11	the	the	DT
cord-257027-q2y7fewk	119	12	Rimaibe	Rimaibe	NNP
cord-257027-q2y7fewk	119	13	,	,	,
cord-257027-q2y7fewk	119	14	and	and	CC
cord-257027-q2y7fewk	119	15	have	have	VBP
cord-257027-q2y7fewk	119	16	lower	low	JJR
cord-257027-q2y7fewk	119	17	parasite	parasite	NN
cord-257027-q2y7fewk	119	18	densities	density	NNS
cord-257027-q2y7fewk	119	19	and	and	CC
cord-257027-q2y7fewk	119	20	fewer	few	JJR
cord-257027-q2y7fewk	119	21	and	and	CC
cord-257027-q2y7fewk	119	22	milder	mild	JJR
cord-257027-q2y7fewk	119	23	malaria	malaria	NN
cord-257027-q2y7fewk	119	24	attacks	attack	NNS
cord-257027-q2y7fewk	119	25	,	,	,
cord-257027-q2y7fewk	119	26	indicating	indicate	VBG
cord-257027-q2y7fewk	119	27	that	that	IN
cord-257027-q2y7fewk	119	28	the	the	DT
cord-257027-q2y7fewk	119	29	Fulani	Fulani	NNPS
cord-257027-q2y7fewk	119	30	are	be	VBP
cord-257027-q2y7fewk	119	31	more	more	RBR
cord-257027-q2y7fewk	119	32	resistant	resistant	JJ
cord-257027-q2y7fewk	119	33	against	against	IN
cord-257027-q2y7fewk	119	34	malaria	malaria	NN
cord-257027-q2y7fewk	119	35	than	than	IN
cord-257027-q2y7fewk	119	36	the	the	DT
cord-257027-q2y7fewk	119	37	Mossi	Mossi	NNP
cord-257027-q2y7fewk	119	38	and	and	CC
cord-257027-q2y7fewk	119	39	the	the	DT
cord-257027-q2y7fewk	119	40	Rimaibe	Rimaibe	NNP
cord-257027-q2y7fewk	119	41	(	(	-LRB-
cord-257027-q2y7fewk	119	42	50	50	CD
cord-257027-q2y7fewk	119	43	)	)	-RRB-
cord-257027-q2y7fewk	119	44	.	.	.
cord-257027-q2y7fewk	120	1	Similarly	similarly	RB
cord-257027-q2y7fewk	120	2	,	,	,
cord-257027-q2y7fewk	120	3	it	-PRON-	PRP
cord-257027-q2y7fewk	120	4	is	be	VBZ
cord-257027-q2y7fewk	120	5	known	know	VBN
cord-257027-q2y7fewk	120	6	that	that	IN
cord-257027-q2y7fewk	120	7	populations	population	NNS
cord-257027-q2y7fewk	120	8	differ	differ	VBP
cord-257027-q2y7fewk	120	9	in	in	IN
cord-257027-q2y7fewk	120	10	their	-PRON-	PRP$
cord-257027-q2y7fewk	120	11	response	response	NN
cord-257027-q2y7fewk	120	12	to	to	IN
cord-257027-q2y7fewk	120	13	vaccination	vaccination	NN
cord-257027-q2y7fewk	120	14	,	,	,
cord-257027-q2y7fewk	120	15	suggesting	suggest	VBG
cord-257027-q2y7fewk	120	16	that	that	IN
cord-257027-q2y7fewk	120	17	populations	population	NNS
cord-257027-q2y7fewk	120	18	differ	differ	VBP
cord-257027-q2y7fewk	120	19	in	in	IN
cord-257027-q2y7fewk	120	20	the	the	DT
cord-257027-q2y7fewk	120	21	frequency	frequency	NN
cord-257027-q2y7fewk	120	22	of	of	IN
cord-257027-q2y7fewk	120	23	the	the	DT
cord-257027-q2y7fewk	120	24	protective	protective	JJ
cord-257027-q2y7fewk	120	25	alleles	allele	NNS
cord-257027-q2y7fewk	120	26	.	.	.
cord-257027-q2y7fewk	121	1	Poland	Poland	NNP
cord-257027-q2y7fewk	121	2	et	et	NNP
cord-257027-q2y7fewk	121	3	al	al	NNP
cord-257027-q2y7fewk	121	4	.	.	.
cord-257027-q2y7fewk	122	1	(	(	-LRB-
cord-257027-q2y7fewk	122	2	51	51	CD
cord-257027-q2y7fewk	122	3	)	)	-RRB-
cord-257027-q2y7fewk	122	4	have	have	VBP
cord-257027-q2y7fewk	122	5	reported	report	VBN
cord-257027-q2y7fewk	122	6	that	that	IN
cord-257027-q2y7fewk	122	7	native	native	JJ
cord-257027-q2y7fewk	122	8	(	(	-LRB-
cord-257027-q2y7fewk	122	9	Innu	Innu	NNP
cord-257027-q2y7fewk	122	10	and	and	CC
cord-257027-q2y7fewk	122	11	Inuit	Inuit	NNP
cord-257027-q2y7fewk	122	12	)	)	-RRB-
cord-257027-q2y7fewk	122	13	and	and	CC
cord-257027-q2y7fewk	122	14	Caucasian	caucasian	JJ
cord-257027-q2y7fewk	122	15	schoolchildren	schoolchildren	NNS
cord-257027-q2y7fewk	122	16	differed	differ	VBD
cord-257027-q2y7fewk	122	17	in	in	IN
cord-257027-q2y7fewk	122	18	their	-PRON-	PRP$
cord-257027-q2y7fewk	122	19	production	production	NN
cord-257027-q2y7fewk	122	20	of	of	IN
cord-257027-q2y7fewk	122	21	antibodies	antibody	NNS
cord-257027-q2y7fewk	122	22	against	against	IN
cord-257027-q2y7fewk	122	23	measles	measles	NN
cord-257027-q2y7fewk	122	24	antigens	antigen	NNS
cord-257027-q2y7fewk	122	25	after	after	IN
cord-257027-q2y7fewk	122	26	vaccination	vaccination	NN
cord-257027-q2y7fewk	122	27	in	in	IN
cord-257027-q2y7fewk	122	28	Canada	Canada	NNP
cord-257027-q2y7fewk	122	29	.	.	.
cord-257027-q2y7fewk	123	1	Additionally	additionally	RB
cord-257027-q2y7fewk	123	2	,	,	,
cord-257027-q2y7fewk	123	3	Malawi	Malawi	NNP
cord-257027-q2y7fewk	123	4	and	and	CC
cord-257027-q2y7fewk	123	5	UK	UK	NNP
cord-257027-q2y7fewk	123	6	populations	population	NNS
cord-257027-q2y7fewk	123	7	strikingly	strikingly	RB
cord-257027-q2y7fewk	123	8	differed	differ	VBD
cord-257027-q2y7fewk	123	9	in	in	IN
cord-257027-q2y7fewk	123	10	the	the	DT
cord-257027-q2y7fewk	123	11	level	level	NN
cord-257027-q2y7fewk	123	12	of	of	IN
cord-257027-q2y7fewk	123	13	prowww.bjournal.com.br	prowww.bjournal.com.br	NN
cord-257027-q2y7fewk	123	14	Braz	Braz	NNP
cord-257027-q2y7fewk	123	15	J	J	NNP
cord-257027-q2y7fewk	123	16	Med	Med	NNP
cord-257027-q2y7fewk	123	17	Biol	Biol	NNP
cord-257027-q2y7fewk	123	18	Res	Res	NNP
cord-257027-q2y7fewk	123	19	45	45	CD
cord-257027-q2y7fewk	123	20	(	(	-LRB-
cord-257027-q2y7fewk	123	21	5	5	CD
cord-257027-q2y7fewk	123	22	)	)	-RRB-
cord-257027-q2y7fewk	124	1	2012	2012	CD
cord-257027-q2y7fewk	124	2	tection	tection	NN
cord-257027-q2y7fewk	124	3	following	follow	VBG
cord-257027-q2y7fewk	124	4	BCG	BCG	NNP
cord-257027-q2y7fewk	124	5	vaccination	vaccination	NN
cord-257027-q2y7fewk	124	6	(	(	-LRB-
cord-257027-q2y7fewk	124	7	i.e.	i.e.	FW
cord-257027-q2y7fewk	124	8	,	,	,
cord-257027-q2y7fewk	124	9	0	0	CD
cord-257027-q2y7fewk	124	10	%	%	NN
cord-257027-q2y7fewk	124	11	in	in	IN
cord-257027-q2y7fewk	124	12	Malawi	Malawi	NNP
cord-257027-q2y7fewk	124	13	and	and	CC
cord-257027-q2y7fewk	124	14	80	80	CD
cord-257027-q2y7fewk	124	15	%	%	NN
cord-257027-q2y7fewk	124	16	in	in	IN
cord-257027-q2y7fewk	124	17	the	the	DT
cord-257027-q2y7fewk	124	18	UK	UK	NNP
cord-257027-q2y7fewk	124	19	)	)	-RRB-
cord-257027-q2y7fewk	124	20	,	,	,
cord-257027-q2y7fewk	124	21	and	and	CC
cord-257027-q2y7fewk	124	22	in	in	IN
cord-257027-q2y7fewk	124	23	their	-PRON-	PRP$
cord-257027-q2y7fewk	124	24	IFN	IFN	NNP
cord-257027-q2y7fewk	124	25	-	-	HYPH
cord-257027-q2y7fewk	124	26	γ	γ	NN
cord-257027-q2y7fewk	124	27	production	production	NN
cord-257027-q2y7fewk	124	28	in	in	IN
cord-257027-q2y7fewk	124	29	response	response	NN
cord-257027-q2y7fewk	124	30	to	to	IN
cord-257027-q2y7fewk	124	31	mycobacterium	mycobacterium	NN
cord-257027-q2y7fewk	124	32	antigens	antigen	NNS
cord-257027-q2y7fewk	124	33	(	(	-LRB-
cord-257027-q2y7fewk	124	34	52	52	CD
cord-257027-q2y7fewk	124	35	)	)	-RRB-
cord-257027-q2y7fewk	124	36	.	.	.
cord-257027-q2y7fewk	125	1	Furthermore	furthermore	RB
cord-257027-q2y7fewk	125	2	,	,	,
cord-257027-q2y7fewk	125	3	native	native	JJ
cord-257027-q2y7fewk	125	4	children	child	NNS
cord-257027-q2y7fewk	125	5	(	(	-LRB-
cord-257027-q2y7fewk	125	6	Navajo	Navajo	NNP
cord-257027-q2y7fewk	125	7	,	,	,
cord-257027-q2y7fewk	125	8	White	White	NNP
cord-257027-q2y7fewk	125	9	Mountain	Mountain	NNP
cord-257027-q2y7fewk	125	10	Apache	Apache	NNP
cord-257027-q2y7fewk	125	11	and	and	CC
cord-257027-q2y7fewk	125	12	Alaska	Alaska	NNP
cord-257027-q2y7fewk	125	13	)	)	-RRB-
cord-257027-q2y7fewk	125	14	and	and	CC
cord-257027-q2y7fewk	125	15	children	child	NNS
cord-257027-q2y7fewk	125	16	in	in	IN
cord-257027-q2y7fewk	125	17	the	the	DT
cord-257027-q2y7fewk	125	18	general	general	JJ
cord-257027-q2y7fewk	125	19	US	US	NNP
cord-257027-q2y7fewk	125	20	population	population	NN
cord-257027-q2y7fewk	125	21	differed	differ	VBD
cord-257027-q2y7fewk	125	22	in	in	IN
cord-257027-q2y7fewk	125	23	the	the	DT
cord-257027-q2y7fewk	125	24	incidence	incidence	NN
cord-257027-q2y7fewk	125	25	of	of	IN
cord-257027-q2y7fewk	125	26	disease	disease	NN
cord-257027-q2y7fewk	125	27	due	due	IN
cord-257027-q2y7fewk	125	28	to	to	IN
cord-257027-q2y7fewk	125	29	H.	h.	NN
cord-257027-q2y7fewk	125	30	influenzae	influenzae	NN
cord-257027-q2y7fewk	125	31	type	type	NN
cord-257027-q2y7fewk	125	32	b	b	NFP
cord-257027-q2y7fewk	125	33	both	both	CC
cord-257027-q2y7fewk	125	34	before	before	IN
cord-257027-q2y7fewk	125	35	and	and	CC
cord-257027-q2y7fewk	125	36	after	after	IN
cord-257027-q2y7fewk	125	37	vaccination	vaccination	NN
cord-257027-q2y7fewk	125	38	,	,	,
cord-257027-q2y7fewk	125	39	indicating	indicate	VBG
cord-257027-q2y7fewk	125	40	that	that	IN
cord-257027-q2y7fewk	125	41	native	native	JJ
cord-257027-q2y7fewk	125	42	children	child	NNS
cord-257027-q2y7fewk	125	43	were	be	VBD
cord-257027-q2y7fewk	125	44	more	more	RBR
cord-257027-q2y7fewk	125	45	susceptible	susceptible	JJ
cord-257027-q2y7fewk	125	46	than	than	IN
cord-257027-q2y7fewk	125	47	other	other	JJ
cord-257027-q2y7fewk	125	48	children	child	NNS
cord-257027-q2y7fewk	125	49	in	in	IN
cord-257027-q2y7fewk	125	50	the	the	DT
cord-257027-q2y7fewk	125	51	US	US	NNP
cord-257027-q2y7fewk	125	52	,	,	,
cord-257027-q2y7fewk	125	53	and	and	CC
cord-257027-q2y7fewk	125	54	that	that	IN
cord-257027-q2y7fewk	125	55	their	-PRON-	PRP$
cord-257027-q2y7fewk	125	56	response	response	NN
cord-257027-q2y7fewk	125	57	to	to	IN
cord-257027-q2y7fewk	125	58	vaccination	vaccination	NN
cord-257027-q2y7fewk	125	59	was	be	VBD
cord-257027-q2y7fewk	125	60	also	also	RB
cord-257027-q2y7fewk	125	61	weaker	weak	JJR
cord-257027-q2y7fewk	125	62	(	(	-LRB-
cord-257027-q2y7fewk	125	63	53	53	CD
cord-257027-q2y7fewk	125	64	)	)	-RRB-
cord-257027-q2y7fewk	125	65	.	.	.
cord-257027-q2y7fewk	126	1	Further	further	JJ
cord-257027-q2y7fewk	126	2	understanding	understanding	NN
cord-257027-q2y7fewk	126	3	of	of	IN
cord-257027-q2y7fewk	126	4	the	the	DT
cord-257027-q2y7fewk	126	5	genetic	genetic	JJ
cord-257027-q2y7fewk	126	6	basis	basis	NN
cord-257027-q2y7fewk	126	7	of	of	IN
cord-257027-q2y7fewk	126	8	variation	variation	NN
cord-257027-q2y7fewk	126	9	in	in	IN
cord-257027-q2y7fewk	126	10	vaccine	vaccine	NN
cord-257027-q2y7fewk	126	11	response	response	NN
cord-257027-q2y7fewk	126	12	may	may	MD
cord-257027-q2y7fewk	126	13	lead	lead	VB
cord-257027-q2y7fewk	126	14	investigators	investigator	NNS
cord-257027-q2y7fewk	126	15	to	to	TO
cord-257027-q2y7fewk	126	16	consider	consider	VB
cord-257027-q2y7fewk	126	17	different	different	JJ
cord-257027-q2y7fewk	126	18	vaccine	vaccine	NN
cord-257027-q2y7fewk	126	19	strategies	strategy	NNS
cord-257027-q2y7fewk	126	20	for	for	IN
cord-257027-q2y7fewk	126	21	groups	group	NNS
cord-257027-q2y7fewk	126	22	having	have	VBG
cord-257027-q2y7fewk	126	23	different	different	JJ
cord-257027-q2y7fewk	126	24	genetic	genetic	JJ
cord-257027-q2y7fewk	126	25	backgrounds	background	NNS
cord-257027-q2y7fewk	126	26	.	.	.
cord-257027-q2y7fewk	127	1	The	the	DT
cord-257027-q2y7fewk	127	2	combination	combination	NN
cord-257027-q2y7fewk	127	3	of	of	IN
cord-257027-q2y7fewk	127	4	high	high	JJ
cord-257027-q2y7fewk	127	5	throughput	throughput	NN
cord-257027-q2y7fewk	127	6	methodologies	methodology	NNS
cord-257027-q2y7fewk	127	7	and	and	CC
cord-257027-q2y7fewk	127	8	multifactorial	multifactorial	JJ
cord-257027-q2y7fewk	127	9	analyses	analysis	NNS
cord-257027-q2y7fewk	127	10	may	may	MD
cord-257027-q2y7fewk	127	11	help	help	VB
cord-257027-q2y7fewk	127	12	in	in	IN
cord-257027-q2y7fewk	127	13	the	the	DT
cord-257027-q2y7fewk	127	14	identification	identification	NN
cord-257027-q2y7fewk	127	15	of	of	IN
cord-257027-q2y7fewk	127	16	genetic	genetic	JJ
cord-257027-q2y7fewk	127	17	markers	marker	NNS
cord-257027-q2y7fewk	127	18	that	that	WDT
cord-257027-q2y7fewk	127	19	affect	affect	VBP
cord-257027-q2y7fewk	127	20	immune	immune	JJ
cord-257027-q2y7fewk	127	21	and	and	CC
cord-257027-q2y7fewk	127	22	physiological	physiological	JJ
cord-257027-q2y7fewk	127	23	responses	response	NNS
cord-257027-q2y7fewk	127	24	leading	lead	VBG
cord-257027-q2y7fewk	127	25	to	to	IN
cord-257027-q2y7fewk	127	26	serious	serious	JJ
cord-257027-q2y7fewk	127	27	adverse	adverse	JJ
cord-257027-q2y7fewk	127	28	effects	effect	NNS
cord-257027-q2y7fewk	127	29	,	,	,
cord-257027-q2y7fewk	127	30	thus	thus	RB
cord-257027-q2y7fewk	127	31	allowing	allow	VBG
cord-257027-q2y7fewk	127	32	the	the	DT
cord-257027-q2y7fewk	127	33	identification	identification	NN
cord-257027-q2y7fewk	127	34	of	of	IN
cord-257027-q2y7fewk	127	35	groups	group	NNS
cord-257027-q2y7fewk	127	36	at	at	IN
cord-257027-q2y7fewk	127	37	risk	risk	NN
cord-257027-q2y7fewk	127	38	of	of	IN
cord-257027-q2y7fewk	127	39	vaccine	vaccine	NN
cord-257027-q2y7fewk	127	40	-	-	HYPH
cord-257027-q2y7fewk	127	41	induced	induce	VBN
cord-257027-q2y7fewk	127	42	adverse	adverse	JJ
cord-257027-q2y7fewk	127	43	events	event	NNS
cord-257027-q2y7fewk	127	44	,	,	,
cord-257027-q2y7fewk	127	45	which	which	WDT
cord-257027-q2y7fewk	127	46	would	would	MD
cord-257027-q2y7fewk	127	47	be	be	VB
cord-257027-q2y7fewk	127	48	entitled	entitle	VBN
cord-257027-q2y7fewk	127	49	to	to	IN
cord-257027-q2y7fewk	127	50	preventive	preventive	JJ
cord-257027-q2y7fewk	127	51	therapies	therapy	NNS
cord-257027-q2y7fewk	127	52	or	or	CC
cord-257027-q2y7fewk	127	53	alternative	alternative	JJ
cord-257027-q2y7fewk	127	54	vaccine	vaccine	NN
cord-257027-q2y7fewk	127	55	formulations	formulation	NNS
cord-257027-q2y7fewk	127	56	(	(	-LRB-
cord-257027-q2y7fewk	127	57	54	54	CD
cord-257027-q2y7fewk	127	58	)	)	-RRB-
cord-257027-q2y7fewk	127	59	.	.	.
cord-257027-q2y7fewk	128	1	In	in	IN
cord-257027-q2y7fewk	128	2	the	the	DT
cord-257027-q2y7fewk	128	3	same	same	JJ
cord-257027-q2y7fewk	128	4	way	way	NN
cord-257027-q2y7fewk	128	5	,	,	,
cord-257027-q2y7fewk	128	6	the	the	DT
cord-257027-q2y7fewk	128	7	exposure	exposure	NN
cord-257027-q2y7fewk	128	8	to	to	IN
cord-257027-q2y7fewk	128	9	the	the	DT
cord-257027-q2y7fewk	128	10	infectious	infectious	JJ
cord-257027-q2y7fewk	128	11	agents	agent	NNS
cord-257027-q2y7fewk	128	12	,	,	,
cord-257027-q2y7fewk	128	13	current	current	JJ
cord-257027-q2y7fewk	128	14	immune	immune	JJ
cord-257027-q2y7fewk	128	15	status	status	NN
cord-257027-q2y7fewk	128	16	(	(	-LRB-
cord-257027-q2y7fewk	128	17	e.g.	e.g.	RB
cord-257027-q2y7fewk	128	18	,	,	,
cord-257027-q2y7fewk	128	19	immunocompromised	immunocompromised	JJ
cord-257027-q2y7fewk	128	20	subjects	subject	NNS
cord-257027-q2y7fewk	128	21	)	)	-RRB-
cord-257027-q2y7fewk	128	22	,	,	,
cord-257027-q2y7fewk	128	23	gender	gender	NN
cord-257027-q2y7fewk	128	24	,	,	,
cord-257027-q2y7fewk	128	25	and	and	CC
cord-257027-q2y7fewk	128	26	age	age	NN
cord-257027-q2y7fewk	128	27	could	could	MD
cord-257027-q2y7fewk	128	28	be	be	VB
cord-257027-q2y7fewk	128	29	taken	take	VBN
cord-257027-q2y7fewk	128	30	into	into	IN
cord-257027-q2y7fewk	128	31	account	account	NN
cord-257027-q2y7fewk	128	32	to	to	TO
cord-257027-q2y7fewk	128	33	minimize	minimize	VB
cord-257027-q2y7fewk	128	34	the	the	DT
cord-257027-q2y7fewk	128	35	rate	rate	NN
cord-257027-q2y7fewk	128	36	of	of	IN
cord-257027-q2y7fewk	128	37	vaccine	vaccine	NN
cord-257027-q2y7fewk	128	38	failure	failure	NN
cord-257027-q2y7fewk	128	39	or	or	CC
cord-257027-q2y7fewk	128	40	vaccine	vaccine	NN
cord-257027-q2y7fewk	128	41	adverse	adverse	JJ
cord-257027-q2y7fewk	128	42	events	event	NNS
cord-257027-q2y7fewk	128	43	.	.	.
cord-257027-q2y7fewk	129	1	Such	such	PDT
cord-257027-q2y7fewk	129	2	a	a	DT
cord-257027-q2y7fewk	129	3	targeted	target	VBN
cord-257027-q2y7fewk	129	4	-	-	HYPH
cord-257027-q2y7fewk	129	5	group	group	NN
cord-257027-q2y7fewk	129	6	vaccination	vaccination	NN
cord-257027-q2y7fewk	129	7	approach	approach	NN
cord-257027-q2y7fewk	129	8	requires	require	VBZ
cord-257027-q2y7fewk	129	9	more	more	JJR
cord-257027-q2y7fewk	129	10	information	information	NN
cord-257027-q2y7fewk	129	11	about	about	IN
cord-257027-q2y7fewk	129	12	the	the	DT
cord-257027-q2y7fewk	129	13	human	human	JJ
cord-257027-q2y7fewk	129	14	groups	group	NNS
cord-257027-q2y7fewk	129	15	of	of	IN
cord-257027-q2y7fewk	129	16	interest	interest	NN
cord-257027-q2y7fewk	129	17	.	.	.
cord-257027-q2y7fewk	130	1	Efforts	effort	NNS
cord-257027-q2y7fewk	130	2	are	be	VBP
cord-257027-q2y7fewk	130	3	particularly	particularly	RB
cord-257027-q2y7fewk	130	4	needed	need	VBN
cord-257027-q2y7fewk	130	5	to	to	TO
cord-257027-q2y7fewk	130	6	study	study	VB
cord-257027-q2y7fewk	130	7	various	various	JJ
cord-257027-q2y7fewk	130	8	populations	population	NNS
cord-257027-q2y7fewk	130	9	in	in	IN
cord-257027-q2y7fewk	130	10	Africa	Africa	NNP
cord-257027-q2y7fewk	130	11	,	,	,
cord-257027-q2y7fewk	130	12	where	where	WRB
cord-257027-q2y7fewk	130	13	genetic	genetic	JJ
cord-257027-q2y7fewk	130	14	diversity	diversity	NN
cord-257027-q2y7fewk	130	15	is	be	VBZ
cord-257027-q2y7fewk	130	16	the	the	DT
cord-257027-q2y7fewk	130	17	most	most	RBS
cord-257027-q2y7fewk	130	18	important	important	JJ
cord-257027-q2y7fewk	130	19	in	in	IN
cord-257027-q2y7fewk	130	20	the	the	DT
cord-257027-q2y7fewk	130	21	world	world	NN
cord-257027-q2y7fewk	130	22	,	,	,
cord-257027-q2y7fewk	130	23	and	and	CC
cord-257027-q2y7fewk	130	24	data	datum	NNS
cord-257027-q2y7fewk	130	25	are	be	VBP
cord-257027-q2y7fewk	130	26	lacking	lack	VBG
cord-257027-q2y7fewk	130	27	.	.	.
cord-257027-q2y7fewk	131	1	In	in	IN
cord-257027-q2y7fewk	131	2	these	these	DT
cord-257027-q2y7fewk	131	3	populations	population	NNS
cord-257027-q2y7fewk	131	4	,	,	,
cord-257027-q2y7fewk	131	5	the	the	DT
cord-257027-q2y7fewk	131	6	international	international	JJ
cord-257027-q2y7fewk	131	7	scientific	scientific	JJ
cord-257027-q2y7fewk	131	8	and	and	CC
cord-257027-q2y7fewk	131	9	medical	medical	JJ
cord-257027-q2y7fewk	131	10	community	community	NN
cord-257027-q2y7fewk	131	11	would	would	MD
cord-257027-q2y7fewk	131	12	be	be	VB
cord-257027-q2y7fewk	131	13	able	able	JJ
cord-257027-q2y7fewk	131	14	to	to	TO
cord-257027-q2y7fewk	131	15	screen	screen	VB
cord-257027-q2y7fewk	131	16	for	for	IN
cord-257027-q2y7fewk	131	17	millions	million	NNS
cord-257027-q2y7fewk	131	18	of	of	IN
cord-257027-q2y7fewk	131	19	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	131	20	within	within	IN
cord-257027-q2y7fewk	131	21	each	each	DT
cord-257027-q2y7fewk	131	22	potential	potential	JJ
cord-257027-q2y7fewk	131	23	target	target	NN
cord-257027-q2y7fewk	131	24	group	group	NN
cord-257027-q2y7fewk	131	25	.	.	.
cord-257027-q2y7fewk	132	1	It	-PRON-	PRP
cord-257027-q2y7fewk	132	2	has	have	VBZ
cord-257027-q2y7fewk	132	3	been	be	VBN
cord-257027-q2y7fewk	132	4	also	also	RB
cord-257027-q2y7fewk	132	5	suggested	suggest	VBN
cord-257027-q2y7fewk	132	6	that	that	IN
cord-257027-q2y7fewk	132	7	profiles	profile	NNS
cord-257027-q2y7fewk	132	8	based	base	VBN
cord-257027-q2y7fewk	132	9	on	on	IN
cord-257027-q2y7fewk	132	10	individual	individual	JJ
cord-257027-q2y7fewk	132	11	information	information	NN
cord-257027-q2y7fewk	132	12	,	,	,
cord-257027-q2y7fewk	132	13	such	such	JJ
cord-257027-q2y7fewk	132	14	as	as	IN
cord-257027-q2y7fewk	132	15	genetic	genetic	JJ
cord-257027-q2y7fewk	132	16	information	information	NN
cord-257027-q2y7fewk	132	17	,	,	,
cord-257027-q2y7fewk	132	18	age	age	NN
cord-257027-q2y7fewk	132	19	,	,	,
cord-257027-q2y7fewk	132	20	and	and	CC
cord-257027-q2y7fewk	132	21	gender	gender	NN
cord-257027-q2y7fewk	132	22	,	,	,
cord-257027-q2y7fewk	132	23	would	would	MD
cord-257027-q2y7fewk	132	24	allow	allow	VB
cord-257027-q2y7fewk	132	25	prediction	prediction	NN
cord-257027-q2y7fewk	132	26	of	of	IN
cord-257027-q2y7fewk	132	27	the	the	DT
cord-257027-q2y7fewk	132	28	need	need	NN
cord-257027-q2y7fewk	132	29	to	to	TO
cord-257027-q2y7fewk	132	30	receive	receive	VB
cord-257027-q2y7fewk	132	31	a	a	DT
cord-257027-q2y7fewk	132	32	given	give	VBN
cord-257027-q2y7fewk	132	33	vaccine	vaccine	NN
cord-257027-q2y7fewk	132	34	(	(	-LRB-
cord-257027-q2y7fewk	132	35	i.e.	i.e.	FW
cord-257027-q2y7fewk	132	36	,	,	,
cord-257027-q2y7fewk	132	37	being	be	VBG
cord-257027-q2y7fewk	132	38	susceptible	susceptible	JJ
cord-257027-q2y7fewk	132	39	to	to	IN
cord-257027-q2y7fewk	132	40	infection	infection	NN
cord-257027-q2y7fewk	132	41	)	)	-RRB-
cord-257027-q2y7fewk	132	42	,	,	,
cord-257027-q2y7fewk	132	43	the	the	DT
cord-257027-q2y7fewk	132	44	number	number	NN
cord-257027-q2y7fewk	132	45	and	and	CC
cord-257027-q2y7fewk	132	46	amount	amount	NN
cord-257027-q2y7fewk	132	47	of	of	IN
cord-257027-q2y7fewk	132	48	doses	dose	NNS
cord-257027-q2y7fewk	132	49	needed	need	VBN
cord-257027-q2y7fewk	132	50	,	,	,
cord-257027-q2y7fewk	132	51	the	the	DT
cord-257027-q2y7fewk	132	52	likelihood	likelihood	NN
cord-257027-q2y7fewk	132	53	of	of	IN
cord-257027-q2y7fewk	132	54	response	response	NN
cord-257027-q2y7fewk	132	55	,	,	,
cord-257027-q2y7fewk	132	56	the	the	DT
cord-257027-q2y7fewk	132	57	likelihood	likelihood	NN
cord-257027-q2y7fewk	132	58	of	of	IN
cord-257027-q2y7fewk	132	59	adverse	adverse	JJ
cord-257027-q2y7fewk	132	60	events	event	NNS
cord-257027-q2y7fewk	132	61	,	,	,
cord-257027-q2y7fewk	132	62	and	and	CC
cord-257027-q2y7fewk	132	63	so	so	RB
cord-257027-q2y7fewk	132	64	on	on	RB
cord-257027-q2y7fewk	132	65	,	,	,
cord-257027-q2y7fewk	132	66	thereby	thereby	RB
cord-257027-q2y7fewk	132	67	making	make	VBG
cord-257027-q2y7fewk	132	68	it	-PRON-	PRP
cord-257027-q2y7fewk	132	69	possible	possible	JJ
cord-257027-q2y7fewk	132	70	to	to	TO
cord-257027-q2y7fewk	132	71	develop	develop	VB
cord-257027-q2y7fewk	132	72	a	a	DT
cord-257027-q2y7fewk	132	73	personalized	personalized	JJ
cord-257027-q2y7fewk	132	74	vaccination	vaccination	NN
cord-257027-q2y7fewk	132	75	approach	approach	NN
cord-257027-q2y7fewk	132	76	.	.	.
cord-257027-q2y7fewk	133	1	At	at	IN
cord-257027-q2y7fewk	133	2	this	this	DT
cord-257027-q2y7fewk	133	3	stage	stage	NN
cord-257027-q2y7fewk	133	4	,	,	,
cord-257027-q2y7fewk	133	5	developing	develop	VBG
cord-257027-q2y7fewk	133	6	a	a	DT
cord-257027-q2y7fewk	133	7	health	health	NN
cord-257027-q2y7fewk	133	8	system	system	NN
cord-257027-q2y7fewk	133	9	in	in	IN
cord-257027-q2y7fewk	133	10	which	which	WDT
cord-257027-q2y7fewk	133	11	each	each	DT
cord-257027-q2y7fewk	133	12	individual	individual	NN
cord-257027-q2y7fewk	133	13	would	would	MD
cord-257027-q2y7fewk	133	14	be	be	VB
cord-257027-q2y7fewk	133	15	genotyped	genotype	VBN
cord-257027-q2y7fewk	133	16	at	at	IN
cord-257027-q2y7fewk	133	17	the	the	DT
cord-257027-q2y7fewk	133	18	genome	genome	NN
cord-257027-q2y7fewk	133	19	scale	scale	NN
cord-257027-q2y7fewk	133	20	would	would	MD
cord-257027-q2y7fewk	133	21	become	become	VB
cord-257027-q2y7fewk	133	22	a	a	DT
cord-257027-q2y7fewk	133	23	political	political	JJ
cord-257027-q2y7fewk	133	24	and	and	CC
cord-257027-q2y7fewk	133	25	economic	economic	JJ
cord-257027-q2y7fewk	133	26	choice	choice	NN
cord-257027-q2y7fewk	133	27	.	.	.
cord-257027-q2y7fewk	134	1	Before	before	IN
cord-257027-q2y7fewk	134	2	coming	come	VBG
cord-257027-q2y7fewk	134	3	to	to	IN
cord-257027-q2y7fewk	134	4	the	the	DT
cord-257027-q2y7fewk	134	5	era	era	NN
cord-257027-q2y7fewk	134	6	of	of	IN
cord-257027-q2y7fewk	134	7	personalized	personalized	JJ
cord-257027-q2y7fewk	134	8	vaccination	vaccination	NN
cord-257027-q2y7fewk	134	9	,	,	,
cord-257027-q2y7fewk	134	10	however	however	RB
cord-257027-q2y7fewk	134	11	,	,	,
cord-257027-q2y7fewk	134	12	we	-PRON-	PRP
cord-257027-q2y7fewk	134	13	should	should	MD
cord-257027-q2y7fewk	134	14	develop	develop	VB
cord-257027-q2y7fewk	134	15	methods	method	NNS
cord-257027-q2y7fewk	134	16	that	that	WDT
cord-257027-q2y7fewk	134	17	will	will	MD
cord-257027-q2y7fewk	134	18	eventually	eventually	RB
cord-257027-q2y7fewk	134	19	allow	allow	VB
cord-257027-q2y7fewk	134	20	us	-PRON-	PRP
cord-257027-q2y7fewk	134	21	to	to	TO
cord-257027-q2y7fewk	134	22	predict	predict	VB
cord-257027-q2y7fewk	134	23	the	the	DT
cord-257027-q2y7fewk	134	24	individual	individual	JJ
cord-257027-q2y7fewk	134	25	response	response	NN
cord-257027-q2y7fewk	134	26	to	to	IN
cord-257027-q2y7fewk	134	27	vaccination	vaccination	NN
cord-257027-q2y7fewk	134	28	on	on	IN
cord-257027-q2y7fewk	134	29	the	the	DT
cord-257027-q2y7fewk	134	30	basis	basis	NN
cord-257027-q2y7fewk	134	31	of	of	IN
cord-257027-q2y7fewk	134	32	individual	individual	JJ
cord-257027-q2y7fewk	134	33	information	information	NN
cord-257027-q2y7fewk	134	34	,	,	,
cord-257027-q2y7fewk	134	35	including	include	VBG
cord-257027-q2y7fewk	134	36	genome	genome	NN
cord-257027-q2y7fewk	134	37	-	-	HYPH
cord-257027-q2y7fewk	134	38	wide	wide	JJ
cord-257027-q2y7fewk	134	39	genotypes	genotype	NNS
cord-257027-q2y7fewk	134	40	.	.	.
cord-257027-q2y7fewk	135	1	The	the	DT
cord-257027-q2y7fewk	135	2	challenge	challenge	NN
cord-257027-q2y7fewk	135	3	is	be	VBZ
cord-257027-q2y7fewk	135	4	less	less	RBR
cord-257027-q2y7fewk	135	5	technological	technological	JJ
cord-257027-q2y7fewk	135	6	than	than	IN
cord-257027-q2y7fewk	135	7	conceptual	conceptual	JJ
cord-257027-q2y7fewk	135	8	.	.	.
cord-257027-q2y7fewk	136	1	The	the	DT
cord-257027-q2y7fewk	136	2	emergence	emergence	NN
cord-257027-q2y7fewk	136	3	of	of	IN
cord-257027-q2y7fewk	136	4	new	new	JJ
cord-257027-q2y7fewk	136	5	technologies	technology	NNS
cord-257027-q2y7fewk	136	6	,	,	,
cord-257027-q2y7fewk	136	7	such	such	JJ
cord-257027-q2y7fewk	136	8	as	as	IN
cord-257027-q2y7fewk	136	9	the	the	DT
cord-257027-q2y7fewk	136	10	microarray	microarray	NN
cord-257027-q2y7fewk	136	11	technology	technology	NN
cord-257027-q2y7fewk	136	12	and	and	CC
cord-257027-q2y7fewk	136	13	more	more	JJR
cord-257027-q2y7fewk	136	14	recently	recently	RB
cord-257027-q2y7fewk	136	15	the	the	DT
cord-257027-q2y7fewk	136	16	next	next	JJ
cord-257027-q2y7fewk	136	17	generation	generation	NN
cord-257027-q2y7fewk	136	18	sequencing	sequencing	NN
cord-257027-q2y7fewk	136	19	technology	technology	NN
cord-257027-q2y7fewk	136	20	,	,	,
cord-257027-q2y7fewk	136	21	gives	give	VBZ
cord-257027-q2y7fewk	136	22	the	the	DT
cord-257027-q2y7fewk	136	23	illusion	illusion	NN
cord-257027-q2y7fewk	136	24	that	that	WDT
cord-257027-q2y7fewk	136	25	genes	gene	NNS
cord-257027-q2y7fewk	136	26	controlling	control	VBG
cord-257027-q2y7fewk	136	27	a	a	DT
cord-257027-q2y7fewk	136	28	complex	complex	JJ
cord-257027-q2y7fewk	136	29	phenotype	phenotype	NN
cord-257027-q2y7fewk	136	30	would	would	MD
cord-257027-q2y7fewk	136	31	be	be	VB
cord-257027-q2y7fewk	136	32	easily	easily	RB
cord-257027-q2y7fewk	136	33	identified	identify	VBN
cord-257027-q2y7fewk	136	34	.	.	.
cord-257027-q2y7fewk	137	1	This	this	DT
cord-257027-q2y7fewk	137	2	is	be	VBZ
cord-257027-q2y7fewk	137	3	due	due	JJ
cord-257027-q2y7fewk	137	4	to	to	IN
cord-257027-q2y7fewk	137	5	the	the	DT
cord-257027-q2y7fewk	137	6	fact	fact	NN
cord-257027-q2y7fewk	137	7	that	that	IN
cord-257027-q2y7fewk	137	8	we	-PRON-	PRP
cord-257027-q2y7fewk	137	9	can	can	MD
cord-257027-q2y7fewk	137	10	obtain	obtain	VB
cord-257027-q2y7fewk	137	11	a	a	DT
cord-257027-q2y7fewk	137	12	huge	huge	JJ
cord-257027-q2y7fewk	137	13	amount	amount	NN
cord-257027-q2y7fewk	137	14	of	of	IN
cord-257027-q2y7fewk	137	15	biological	biological	JJ
cord-257027-q2y7fewk	137	16	data	datum	NNS
cord-257027-q2y7fewk	137	17	for	for	IN
cord-257027-q2y7fewk	137	18	one	one	CD
cord-257027-q2y7fewk	137	19	sample	sample	NN
cord-257027-q2y7fewk	137	20	.	.	.
cord-257027-q2y7fewk	138	1	For	for	IN
cord-257027-q2y7fewk	138	2	example	example	NN
cord-257027-q2y7fewk	138	3	,	,	,
cord-257027-q2y7fewk	138	4	the	the	DT
cord-257027-q2y7fewk	138	5	whole	whole	JJ
cord-257027-q2y7fewk	138	6	-	-	HYPH
cord-257027-q2y7fewk	138	7	genome	genome	NN
cord-257027-q2y7fewk	138	8	transcriptome	transcriptome	NN
cord-257027-q2y7fewk	138	9	can	can	MD
cord-257027-q2y7fewk	138	10	be	be	VB
cord-257027-q2y7fewk	138	11	analyzed	analyze	VBN
cord-257027-q2y7fewk	138	12	by	by	IN
cord-257027-q2y7fewk	138	13	using	use	VBG
cord-257027-q2y7fewk	138	14	one	one	CD
cord-257027-q2y7fewk	138	15	array	array	NN
cord-257027-q2y7fewk	138	16	for	for	IN
cord-257027-q2y7fewk	138	17	an	an	DT
cord-257027-q2y7fewk	138	18	individual	individual	NN
cord-257027-q2y7fewk	138	19	,	,	,
cord-257027-q2y7fewk	138	20	and	and	CC
cord-257027-q2y7fewk	138	21	more	more	JJR
cord-257027-q2y7fewk	138	22	than	than	IN
cord-257027-q2y7fewk	138	23	500,000	500,000	CD
cord-257027-q2y7fewk	138	24	SNPs	snp	NNS
cord-257027-q2y7fewk	138	25	can	can	MD
cord-257027-q2y7fewk	138	26	be	be	VB
cord-257027-q2y7fewk	138	27	simultaneously	simultaneously	RB
cord-257027-q2y7fewk	138	28	genotyped	genotype	VBN
cord-257027-q2y7fewk	138	29	by	by	IN
cord-257027-q2y7fewk	138	30	using	use	VBG
cord-257027-q2y7fewk	138	31	SNP	SNP	NNP
cord-257027-q2y7fewk	138	32	arrays	array	NNS
cord-257027-q2y7fewk	138	33	for	for	IN
cord-257027-q2y7fewk	138	34	the	the	DT
cord-257027-q2y7fewk	138	35	same	same	JJ
cord-257027-q2y7fewk	138	36	individual	individual	NN
cord-257027-q2y7fewk	138	37	(	(	-LRB-
cord-257027-q2y7fewk	138	38	the	the	DT
cord-257027-q2y7fewk	138	39	last	last	JJ
cord-257027-q2y7fewk	138	40	generation	generation	NN
cord-257027-q2y7fewk	138	41	of	of	IN
cord-257027-q2y7fewk	138	42	Affymetrix	Affymetrix	NNP
cord-257027-q2y7fewk	138	43	chips	chip	NNS
cord-257027-q2y7fewk	138	44	allows	allow	VBZ
cord-257027-q2y7fewk	138	45	the	the	DT
cord-257027-q2y7fewk	138	46	analysis	analysis	NN
cord-257027-q2y7fewk	138	47	of	of	IN
cord-257027-q2y7fewk	138	48	1,8	1,8	CD
cord-257027-q2y7fewk	138	49	million	million	CD
cord-257027-q2y7fewk	138	50	SNPs	SNPs	NNPS
cord-257027-q2y7fewk	138	51	)	)	-RRB-
cord-257027-q2y7fewk	138	52	.	.	.
cord-257027-q2y7fewk	139	1	The	the	DT
cord-257027-q2y7fewk	139	2	nextgeneration	nextgeneration	NN
cord-257027-q2y7fewk	139	3	sequencers	sequencer	NNS
cord-257027-q2y7fewk	139	4	(	(	-LRB-
cord-257027-q2y7fewk	139	5	solexa	solexa	NNP
cord-257027-q2y7fewk	139	6	/	/	SYM
cord-257027-q2y7fewk	139	7	illumina	illumina	NNP
cord-257027-q2y7fewk	139	8	and	and	CC
cord-257027-q2y7fewk	139	9	solid	solid	JJ
cord-257027-q2y7fewk	139	10	/	/	SYM
cord-257027-q2y7fewk	139	11	ABI	ABI	NNP
cord-257027-q2y7fewk	139	12	)	)	-RRB-
cord-257027-q2y7fewk	139	13	allow	allow	VB
cord-257027-q2y7fewk	139	14	the	the	DT
cord-257027-q2y7fewk	139	15	analysis	analysis	NN
cord-257027-q2y7fewk	139	16	of	of	IN
cord-257027-q2y7fewk	139	17	the	the	DT
cord-257027-q2y7fewk	139	18	transcriptome	transcriptome	NN
cord-257027-q2y7fewk	139	19	,	,	,
cord-257027-q2y7fewk	139	20	of	of	IN
cord-257027-q2y7fewk	139	21	small	small	JJ
cord-257027-q2y7fewk	139	22	RNAs	rna	NNS
cord-257027-q2y7fewk	139	23	,	,	,
cord-257027-q2y7fewk	139	24	of	of	IN
cord-257027-q2y7fewk	139	25	DNA	dna	NN
cord-257027-q2y7fewk	139	26	methylation	methylation	NN
cord-257027-q2y7fewk	139	27	,	,	,
cord-257027-q2y7fewk	139	28	of	of	IN
cord-257027-q2y7fewk	139	29	SNPs	SNPs	NNPS
cord-257027-q2y7fewk	139	30	,	,	,
cord-257027-q2y7fewk	139	31	and	and	CC
cord-257027-q2y7fewk	139	32	of	of	IN
cord-257027-q2y7fewk	139	33	copy	copy	JJ
cord-257027-q2y7fewk	139	34	number	number	NN
cord-257027-q2y7fewk	139	35	variation	variation	NN
cord-257027-q2y7fewk	139	36	at	at	IN
cord-257027-q2y7fewk	139	37	the	the	DT
cord-257027-q2y7fewk	139	38	genome	genome	NN
cord-257027-q2y7fewk	139	39	scale	scale	NN
cord-257027-q2y7fewk	139	40	(	(	-LRB-
cord-257027-q2y7fewk	139	41	55	55	CD
cord-257027-q2y7fewk	139	42	)	)	-RRB-
cord-257027-q2y7fewk	139	43	.	.	.
cord-257027-q2y7fewk	140	1	All	all	PDT
cord-257027-q2y7fewk	140	2	these	these	DT
cord-257027-q2y7fewk	140	3	technologies	technology	NNS
cord-257027-q2y7fewk	140	4	can	can	MD
cord-257027-q2y7fewk	140	5	produce	produce	VB
cord-257027-q2y7fewk	140	6	a	a	DT
cord-257027-q2y7fewk	140	7	huge	huge	JJ
cord-257027-q2y7fewk	140	8	amount	amount	NN
cord-257027-q2y7fewk	140	9	of	of	IN
cord-257027-q2y7fewk	140	10	data	datum	NNS
cord-257027-q2y7fewk	140	11	that	that	WDT
cord-257027-q2y7fewk	140	12	need	need	VBP
cord-257027-q2y7fewk	140	13	to	to	TO
cord-257027-q2y7fewk	140	14	be	be	VB
cord-257027-q2y7fewk	140	15	stored	store	VBN
cord-257027-q2y7fewk	140	16	,	,	,
cord-257027-q2y7fewk	140	17	transferred	transfer	VBN
cord-257027-q2y7fewk	140	18	,	,	,
cord-257027-q2y7fewk	140	19	carefully	carefully	RB
cord-257027-q2y7fewk	140	20	analyzed	analyze	VBD
cord-257027-q2y7fewk	140	21	and	and	CC
cord-257027-q2y7fewk	140	22	interpreted	interpret	VBN
cord-257027-q2y7fewk	140	23	.	.	.
cord-257027-q2y7fewk	141	1	The	the	DT
cord-257027-q2y7fewk	141	2	statistical	statistical	JJ
cord-257027-q2y7fewk	141	3	analysis	analysis	NN
cord-257027-q2y7fewk	141	4	is	be	VBZ
cord-257027-q2y7fewk	141	5	a	a	DT
cord-257027-q2y7fewk	141	6	significant	significant	JJ
cord-257027-q2y7fewk	141	7	challenge	challenge	NN
cord-257027-q2y7fewk	141	8	because	because	IN
cord-257027-q2y7fewk	141	9	a	a	DT
cord-257027-q2y7fewk	141	10	number	number	NN
cord-257027-q2y7fewk	141	11	of	of	IN
cord-257027-q2y7fewk	141	12	statistical	statistical	JJ
cord-257027-q2y7fewk	141	13	tests	test	NNS
cord-257027-q2y7fewk	141	14	are	be	VBP
cord-257027-q2y7fewk	141	15	performed	perform	VBN
cord-257027-q2y7fewk	141	16	;	;	:
cord-257027-q2y7fewk	141	17	to	to	TO
cord-257027-q2y7fewk	141	18	tackle	tackle	VB
cord-257027-q2y7fewk	141	19	this	this	DT
cord-257027-q2y7fewk	141	20	multi	multi	JJ
cord-257027-q2y7fewk	141	21	-	-	JJ
cord-257027-q2y7fewk	141	22	testing	testing	JJ
cord-257027-q2y7fewk	141	23	problem	problem	NN
cord-257027-q2y7fewk	141	24	,	,	,
cord-257027-q2y7fewk	141	25	new	new	JJ
cord-257027-q2y7fewk	141	26	approaches	approach	NNS
cord-257027-q2y7fewk	141	27	have	have	VBP
cord-257027-q2y7fewk	141	28	been	be	VBN
cord-257027-q2y7fewk	141	29	proposed	propose	VBN
cord-257027-q2y7fewk	141	30	(	(	-LRB-
cord-257027-q2y7fewk	141	31	55	55	CD
cord-257027-q2y7fewk	141	32	,	,	,
cord-257027-q2y7fewk	141	33	56	56	CD
cord-257027-q2y7fewk	141	34	)	)	-RRB-
cord-257027-q2y7fewk	141	35	.	.	.
cord-257027-q2y7fewk	142	1	Such	such	JJ
cord-257027-q2y7fewk	142	2	approaches	approach	NNS
cord-257027-q2y7fewk	142	3	have	have	VBP
cord-257027-q2y7fewk	142	4	been	be	VBN
cord-257027-q2y7fewk	142	5	used	use	VBN
cord-257027-q2y7fewk	142	6	in	in	IN
cord-257027-q2y7fewk	142	7	genome	genome	NN
cord-257027-q2y7fewk	142	8	-	-	HYPH
cord-257027-q2y7fewk	142	9	wide	wide	JJ
cord-257027-q2y7fewk	142	10	studies	study	NNS
cord-257027-q2y7fewk	142	11	and	and	CC
cord-257027-q2y7fewk	142	12	have	have	VBP
cord-257027-q2y7fewk	142	13	provided	provide	VBN
cord-257027-q2y7fewk	142	14	significant	significant	JJ
cord-257027-q2y7fewk	142	15	results	result	NNS
cord-257027-q2y7fewk	142	16	from	from	IN
cord-257027-q2y7fewk	142	17	the	the	DT
cord-257027-q2y7fewk	142	18	statistical	statistical	JJ
cord-257027-q2y7fewk	142	19	point	point	NN
cord-257027-q2y7fewk	142	20	of	of	IN
cord-257027-q2y7fewk	142	21	view	view	NN
cord-257027-q2y7fewk	142	22	.	.	.
cord-257027-q2y7fewk	143	1	However	however	RB
cord-257027-q2y7fewk	143	2	,	,	,
cord-257027-q2y7fewk	143	3	it	-PRON-	PRP
cord-257027-q2y7fewk	143	4	is	be	VBZ
cord-257027-q2y7fewk	143	5	clear	clear	JJ
cord-257027-q2y7fewk	143	6	that	that	IN
cord-257027-q2y7fewk	143	7	most	most	RBS
cord-257027-q2y7fewk	143	8	biological	biological	JJ
cord-257027-q2y7fewk	143	9	information	information	NN
cord-257027-q2y7fewk	143	10	is	be	VBZ
cord-257027-q2y7fewk	143	11	missing	miss	VBG
cord-257027-q2y7fewk	143	12	.	.	.
cord-257027-q2y7fewk	144	1	This	this	DT
cord-257027-q2y7fewk	144	2	lack	lack	NN
cord-257027-q2y7fewk	144	3	is	be	VBZ
cord-257027-q2y7fewk	144	4	highlighted	highlight	VBN
cord-257027-q2y7fewk	144	5	by	by	IN
cord-257027-q2y7fewk	144	6	the	the	DT
cord-257027-q2y7fewk	144	7	results	result	NNS
cord-257027-q2y7fewk	144	8	obtained	obtain	VBN
cord-257027-q2y7fewk	144	9	in	in	IN
cord-257027-q2y7fewk	144	10	genome	genome	NN
cord-257027-q2y7fewk	144	11	-	-	HYPH
cord-257027-q2y7fewk	144	12	wide	wide	JJ
cord-257027-q2y7fewk	144	13	linkage	linkage	NN
cord-257027-q2y7fewk	144	14	and	and	CC
cord-257027-q2y7fewk	144	15	association	association	NN
cord-257027-q2y7fewk	144	16	in	in	IN
cord-257027-q2y7fewk	144	17	infectious	infectious	JJ
cord-257027-q2y7fewk	144	18	diseases	disease	NNS
cord-257027-q2y7fewk	144	19	.	.	.
cord-257027-q2y7fewk	145	1	For	for	IN
cord-257027-q2y7fewk	145	2	instance	instance	NN
cord-257027-q2y7fewk	145	3	,	,	,
cord-257027-q2y7fewk	145	4	Fellay	Fellay	NNP
cord-257027-q2y7fewk	145	5	et	et	NNP
cord-257027-q2y7fewk	145	6	al	al	NNP
cord-257027-q2y7fewk	145	7	.	.	.
cord-257027-q2y7fewk	146	1	(	(	-LRB-
cord-257027-q2y7fewk	146	2	40	40	CD
cord-257027-q2y7fewk	146	3	)	)	-RRB-
cord-257027-q2y7fewk	146	4	estimated	estimate	VBD
cord-257027-q2y7fewk	146	5	that	that	IN
cord-257027-q2y7fewk	146	6	the	the	DT
cord-257027-q2y7fewk	146	7	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	146	8	identified	identify	VBN
cord-257027-q2y7fewk	146	9	explained	explain	VBD
cord-257027-q2y7fewk	146	10	15	15	CD
cord-257027-q2y7fewk	146	11	%	%	NN
cord-257027-q2y7fewk	146	12	of	of	IN
cord-257027-q2y7fewk	146	13	the	the	DT
cord-257027-q2y7fewk	146	14	virus	virus	NN
cord-257027-q2y7fewk	146	15	load	load	NN
cord-257027-q2y7fewk	146	16	variance	variance	NN
cord-257027-q2y7fewk	146	17	in	in	IN
cord-257027-q2y7fewk	146	18	the	the	DT
cord-257027-q2y7fewk	146	19	study	study	NN
cord-257027-q2y7fewk	146	20	population	population	NN
cord-257027-q2y7fewk	146	21	,	,	,
cord-257027-q2y7fewk	146	22	suggesting	suggest	VBG
cord-257027-q2y7fewk	146	23	that	that	IN
cord-257027-q2y7fewk	146	24	the	the	DT
cord-257027-q2y7fewk	146	25	effect	effect	NN
cord-257027-q2y7fewk	146	26	of	of	IN
cord-257027-q2y7fewk	146	27	other	other	JJ
cord-257027-q2y7fewk	146	28	genes	gene	NNS
cord-257027-q2y7fewk	146	29	had	have	VBD
cord-257027-q2y7fewk	146	30	not	not	RB
cord-257027-q2y7fewk	146	31	been	be	VBN
cord-257027-q2y7fewk	146	32	detected	detect	VBN
cord-257027-q2y7fewk	146	33	.	.	.
cord-257027-q2y7fewk	147	1	Strikingly	strikingly	RB
cord-257027-q2y7fewk	147	2	,	,	,
cord-257027-q2y7fewk	147	3	a	a	DT
cord-257027-q2y7fewk	147	4	genome	genome	NN
cord-257027-q2y7fewk	147	5	-	-	HYPH
cord-257027-q2y7fewk	147	6	wide	wide	JJ
cord-257027-q2y7fewk	147	7	association	association	NN
cord-257027-q2y7fewk	147	8	study	study	NN
cord-257027-q2y7fewk	147	9	only	only	RB
cord-257027-q2y7fewk	147	10	detected	detect	VBD
cord-257027-q2y7fewk	147	11	the	the	DT
cord-257027-q2y7fewk	147	12	association	association	NN
cord-257027-q2y7fewk	147	13	between	between	IN
cord-257027-q2y7fewk	147	14	protection	protection	NN
cord-257027-q2y7fewk	147	15	against	against	IN
cord-257027-q2y7fewk	147	16	severe	severe	JJ
cord-257027-q2y7fewk	147	17	malaria	malaria	NN
cord-257027-q2y7fewk	147	18	and	and	CC
cord-257027-q2y7fewk	147	19	hemoglobin	hemoglobin	NN
cord-257027-q2y7fewk	147	20	S	S	NNP
cord-257027-q2y7fewk	147	21	after	after	IN
cord-257027-q2y7fewk	147	22	correcting	correct	VBG
cord-257027-q2y7fewk	147	23	for	for	IN
cord-257027-q2y7fewk	147	24	multi	multi	JJ
cord-257027-q2y7fewk	147	25	-	-	NNS
cord-257027-q2y7fewk	147	26	tests	test	NNS
cord-257027-q2y7fewk	147	27	(	(	-LRB-
cord-257027-q2y7fewk	147	28	35	35	CD
cord-257027-q2y7fewk	147	29	)	)	-RRB-
cord-257027-q2y7fewk	147	30	,	,	,
cord-257027-q2y7fewk	147	31	while	while	IN
cord-257027-q2y7fewk	147	32	several	several	JJ
cord-257027-q2y7fewk	147	33	other	other	JJ
cord-257027-q2y7fewk	147	34	genes	gene	NNS
cord-257027-q2y7fewk	147	35	and	and	CC
cord-257027-q2y7fewk	147	36	genetic	genetic	JJ
cord-257027-q2y7fewk	147	37	variants	variant	NNS
cord-257027-q2y7fewk	147	38	have	have	VBP
cord-257027-q2y7fewk	147	39	been	be	VBN
cord-257027-q2y7fewk	147	40	associated	associate	VBN
cord-257027-q2y7fewk	147	41	with	with	IN
cord-257027-q2y7fewk	147	42	severe	severe	JJ
cord-257027-q2y7fewk	147	43	malaria	malaria	NN
cord-257027-q2y7fewk	147	44	in	in	IN
cord-257027-q2y7fewk	147	45	independent	independent	JJ
cord-257027-q2y7fewk	147	46	populations	population	NNS
cord-257027-q2y7fewk	147	47	(	(	-LRB-
cord-257027-q2y7fewk	147	48	57	57	CD
cord-257027-q2y7fewk	147	49	)	)	-RRB-
cord-257027-q2y7fewk	147	50	.	.	.
cord-257027-q2y7fewk	148	1	It	-PRON-	PRP
cord-257027-q2y7fewk	148	2	is	be	VBZ
cord-257027-q2y7fewk	148	3	clear	clear	JJ
cord-257027-q2y7fewk	148	4	that	that	IN
cord-257027-q2y7fewk	148	5	the	the	DT
cord-257027-q2y7fewk	148	6	biological	biological	JJ
cord-257027-q2y7fewk	148	7	interpretation	interpretation	NN
cord-257027-q2y7fewk	148	8	of	of	IN
cord-257027-q2y7fewk	148	9	such	such	JJ
cord-257027-q2y7fewk	148	10	data	datum	NNS
cord-257027-q2y7fewk	148	11	needs	need	VBZ
cord-257027-q2y7fewk	148	12	an	an	DT
cord-257027-q2y7fewk	148	13	integration	integration	NN
cord-257027-q2y7fewk	148	14	of	of	IN
cord-257027-q2y7fewk	148	15	various	various	JJ
cord-257027-q2y7fewk	148	16	biological	biological	JJ
cord-257027-q2y7fewk	148	17	data	datum	NNS
cord-257027-q2y7fewk	148	18	stored	store	VBN
cord-257027-q2y7fewk	148	19	in	in	IN
cord-257027-q2y7fewk	148	20	different	different	JJ
cord-257027-q2y7fewk	148	21	databases	database	NNS
cord-257027-q2y7fewk	148	22	,	,	,
cord-257027-q2y7fewk	148	23	and	and	CC
cord-257027-q2y7fewk	148	24	statistical	statistical	JJ
cord-257027-q2y7fewk	148	25	approaches	approach	NNS
cord-257027-q2y7fewk	148	26	that	that	WDT
cord-257027-q2y7fewk	148	27	make	make	VBP
cord-257027-q2y7fewk	148	28	use	use	NN
cord-257027-q2y7fewk	148	29	of	of	IN
cord-257027-q2y7fewk	148	30	these	these	DT
cord-257027-q2y7fewk	148	31	data	datum	NNS
cord-257027-q2y7fewk	148	32	.	.	.
cord-257027-q2y7fewk	149	1	The	the	DT
cord-257027-q2y7fewk	149	2	central	central	JJ
cord-257027-q2y7fewk	149	3	concept	concept	NN
cord-257027-q2y7fewk	149	4	that	that	WDT
cord-257027-q2y7fewk	149	5	can	can	MD
cord-257027-q2y7fewk	149	6	drive	drive	VB
cord-257027-q2y7fewk	149	7	the	the	DT
cord-257027-q2y7fewk	149	8	development	development	NN
cord-257027-q2y7fewk	149	9	of	of	IN
cord-257027-q2y7fewk	149	10	new	new	JJ
cord-257027-q2y7fewk	149	11	approaches	approach	NNS
cord-257027-q2y7fewk	149	12	is	be	VBZ
cord-257027-q2y7fewk	149	13	the	the	DT
cord-257027-q2y7fewk	149	14	molecular	molecular	JJ
cord-257027-q2y7fewk	149	15	network	network	NN
cord-257027-q2y7fewk	149	16	.	.	.
cord-257027-q2y7fewk	150	1	Figure	figure	NN
cord-257027-q2y7fewk	150	2	2	2	CD
cord-257027-q2y7fewk	150	3	represents	represent	VBZ
cord-257027-q2y7fewk	150	4	this	this	DT
cord-257027-q2y7fewk	150	5	concept	concept	NN
cord-257027-q2y7fewk	150	6	in	in	IN
cord-257027-q2y7fewk	150	7	the	the	DT
cord-257027-q2y7fewk	150	8	context	context	NN
cord-257027-q2y7fewk	150	9	of	of	IN
cord-257027-q2y7fewk	150	10	infectious	infectious	JJ
cord-257027-q2y7fewk	150	11	diseases	disease	NNS
cord-257027-q2y7fewk	150	12	.	.	.
cord-257027-q2y7fewk	151	1	This	this	DT
cord-257027-q2y7fewk	151	2	concept	concept	NN
cord-257027-q2y7fewk	151	3	has	have	VBZ
cord-257027-q2y7fewk	151	4	stimulated	stimulate	VBN
cord-257027-q2y7fewk	151	5	the	the	DT
cord-257027-q2y7fewk	151	6	development	development	NN
cord-257027-q2y7fewk	151	7	of	of	IN
cord-257027-q2y7fewk	151	8	gene	gene	NN
cord-257027-q2y7fewk	151	9	prioritization	prioritization	NN
cord-257027-q2y7fewk	151	10	tools	tool	NNS
cord-257027-q2y7fewk	151	11	to	to	TO
cord-257027-q2y7fewk	151	12	propose	propose	VB
cord-257027-q2y7fewk	151	13	candidate	candidate	NN
cord-257027-q2y7fewk	151	14	genes	gene	NNS
cord-257027-q2y7fewk	151	15	lying	lie	VBG
cord-257027-q2y7fewk	151	16	within	within	IN
cord-257027-q2y7fewk	151	17	a	a	DT
cord-257027-q2y7fewk	151	18	chromosomal	chromosomal	JJ
cord-257027-q2y7fewk	151	19	region	region	NN
cord-257027-q2y7fewk	151	20	linked	link	VBN
cord-257027-q2y7fewk	151	21	to	to	IN
cord-257027-q2y7fewk	151	22	the	the	DT
cord-257027-q2y7fewk	151	23	disease	disease	NN
cord-257027-q2y7fewk	151	24	.	.	.
cord-257027-q2y7fewk	152	1	The	the	DT
cord-257027-q2y7fewk	152	2	approaches	approach	NNS
cord-257027-q2y7fewk	152	3	used	use	VBN
cord-257027-q2y7fewk	152	4	imply	imply	VBP
cord-257027-q2y7fewk	152	5	that	that	IN
cord-257027-q2y7fewk	152	6	most	most	JJS
cord-257027-q2y7fewk	152	7	genes	gene	NNS
cord-257027-q2y7fewk	152	8	involved	involve	VBN
cord-257027-q2y7fewk	152	9	in	in	IN
cord-257027-q2y7fewk	152	10	a	a	DT
cord-257027-q2y7fewk	152	11	disease	disease	NN
cord-257027-q2y7fewk	152	12	share	share	VB
cord-257027-q2y7fewk	152	13	functional	functional	JJ
cord-257027-q2y7fewk	152	14	properties	property	NNS
cord-257027-q2y7fewk	152	15	and/or	and/or	CC
cord-257027-q2y7fewk	152	16	can	can	MD
cord-257027-q2y7fewk	152	17	be	be	VB
cord-257027-q2y7fewk	152	18	mapped	map	VBN
cord-257027-q2y7fewk	152	19	in	in	IN
cord-257027-q2y7fewk	152	20	the	the	DT
cord-257027-q2y7fewk	152	21	same	same	JJ
cord-257027-q2y7fewk	152	22	gene	gene	NN
cord-257027-q2y7fewk	152	23	or	or	CC
cord-257027-q2y7fewk	152	24	protein	protein	NN
cord-257027-q2y7fewk	152	25	network	network	NN
cord-257027-q2y7fewk	152	26	.	.	.
cord-257027-q2y7fewk	153	1	The	the	DT
cord-257027-q2y7fewk	153	2	most	most	RBS
cord-257027-q2y7fewk	153	3	frequent	frequent	JJ
cord-257027-q2y7fewk	153	4	approach	approach	NN
cord-257027-q2y7fewk	153	5	is	be	VBZ
cord-257027-q2y7fewk	153	6	to	to	TO
cord-257027-q2y7fewk	153	7	rank	rank	VB
cord-257027-q2y7fewk	153	8	candidates	candidate	NNS
cord-257027-q2y7fewk	153	9	on	on	IN
cord-257027-q2y7fewk	153	10	the	the	DT
cord-257027-q2y7fewk	153	11	basis	basis	NN
cord-257027-q2y7fewk	153	12	of	of	IN
cord-257027-q2y7fewk	153	13	their	-PRON-	PRP$
cord-257027-q2y7fewk	153	14	similarity	similarity	NN
cord-257027-q2y7fewk	153	15	to	to	IN
cord-257027-q2y7fewk	153	16	a	a	DT
cord-257027-q2y7fewk	153	17	set	set	NN
cord-257027-q2y7fewk	153	18	of	of	IN
cord-257027-q2y7fewk	153	19	training	training	NN
cord-257027-q2y7fewk	153	20	genes	gene	NNS
cord-257027-q2y7fewk	153	21	that	that	WDT
cord-257027-q2y7fewk	153	22	have	have	VBP
cord-257027-q2y7fewk	153	23	been	be	VBN
cord-257027-q2y7fewk	153	24	demonstrated	demonstrate	VBN
cord-257027-q2y7fewk	153	25	to	to	TO
cord-257027-q2y7fewk	153	26	be	be	VB
cord-257027-q2y7fewk	153	27	involved	involve	VBN
cord-257027-q2y7fewk	153	28	in	in	IN
cord-257027-q2y7fewk	153	29	the	the	DT
cord-257027-q2y7fewk	153	30	disease	disease	NN
cord-257027-q2y7fewk	153	31	(	(	-LRB-
cord-257027-q2y7fewk	153	32	reviewed	review	VBN
cord-257027-q2y7fewk	153	33	in	in	IN
cord-257027-q2y7fewk	153	34	Ref	Ref	NNP
cord-257027-q2y7fewk	153	35	.	.	.
cord-257027-q2y7fewk	154	1	58	58	CD
cord-257027-q2y7fewk	154	2	)	)	-RRB-
cord-257027-q2y7fewk	154	3	.	.	.
cord-257027-q2y7fewk	155	1	The	the	DT
cord-257027-q2y7fewk	155	2	biological	biological	JJ
cord-257027-q2y7fewk	155	3	concept	concept	NN
cord-257027-q2y7fewk	155	4	of	of	IN
cord-257027-q2y7fewk	155	5	the	the	DT
cord-257027-q2y7fewk	155	6	gene	gene	NN
cord-257027-q2y7fewk	155	7	network	network	NN
cord-257027-q2y7fewk	155	8	implies	imply	VBZ
cord-257027-q2y7fewk	155	9	the	the	DT
cord-257027-q2y7fewk	155	10	existence	existence	NN
cord-257027-q2y7fewk	155	11	of	of	IN
cord-257027-q2y7fewk	155	12	gene	gene	NN
cord-257027-q2y7fewk	155	13	-	-	HYPH
cord-257027-q2y7fewk	155	14	gene	gene	NN
cord-257027-q2y7fewk	155	15	interactions	interaction	NNS
cord-257027-q2y7fewk	155	16	that	that	WDT
cord-257027-q2y7fewk	155	17	are	be	VBP
cord-257027-q2y7fewk	155	18	generally	generally	RB
cord-257027-q2y7fewk	155	19	not	not	RB
cord-257027-q2y7fewk	155	20	taken	take	VBN
cord-257027-q2y7fewk	155	21	into	into	IN
cord-257027-q2y7fewk	155	22	account	account	NN
cord-257027-q2y7fewk	155	23	in	in	IN
cord-257027-q2y7fewk	155	24	genome	genome	NN
cord-257027-q2y7fewk	155	25	-	-	HYPH
cord-257027-q2y7fewk	155	26	wide	wide	JJ
cord-257027-q2y7fewk	155	27	linkage	linkage	NN
cord-257027-q2y7fewk	155	28	and	and	CC
cord-257027-q2y7fewk	155	29	association	association	NN
cord-257027-q2y7fewk	155	30	analyses	analysis	NNS
cord-257027-q2y7fewk	155	31	.	.	.
cord-257027-q2y7fewk	156	1	Genegene	genegene	JJ
cord-257027-q2y7fewk	156	2	interaction	interaction	NN
cord-257027-q2y7fewk	156	3	can	can	MD
cord-257027-q2y7fewk	156	4	be	be	VB
cord-257027-q2y7fewk	156	5	explicitly	explicitly	RB
cord-257027-q2y7fewk	156	6	included	include	VBN
cord-257027-q2y7fewk	156	7	in	in	IN
cord-257027-q2y7fewk	156	8	the	the	DT
cord-257027-q2y7fewk	156	9	models	model	NNS
cord-257027-q2y7fewk	156	10	used	use	VBN
cord-257027-q2y7fewk	156	11	in	in	IN
cord-257027-q2y7fewk	156	12	linkage	linkage	NN
cord-257027-q2y7fewk	156	13	and	and	CC
cord-257027-q2y7fewk	156	14	association	association	NN
cord-257027-q2y7fewk	156	15	analyses	analysis	NNS
cord-257027-q2y7fewk	156	16	.	.	.
cord-257027-q2y7fewk	157	1	Statistical	statistical	JJ
cord-257027-q2y7fewk	157	2	approaches	approach	NNS
cord-257027-q2y7fewk	157	3	have	have	VBP
cord-257027-q2y7fewk	157	4	been	be	VBN
cord-257027-q2y7fewk	157	5	proposed	propose	VBN
cord-257027-q2y7fewk	157	6	to	to	TO
cord-257027-q2y7fewk	157	7	detect	detect	VB
cord-257027-q2y7fewk	157	8	such	such	JJ
cord-257027-q2y7fewk	157	9	interactions	interaction	NNS
cord-257027-q2y7fewk	157	10	also	also	RB
cord-257027-q2y7fewk	157	11	in	in	IN
cord-257027-q2y7fewk	157	12	studies	study	NNS
cord-257027-q2y7fewk	157	13	of	of	IN
cord-257027-q2y7fewk	157	14	vaccine	vaccine	NN
cord-257027-q2y7fewk	157	15	responses	response	NNS
cord-257027-q2y7fewk	157	16	(	(	-LRB-
cord-257027-q2y7fewk	157	17	59	59	CD
cord-257027-q2y7fewk	157	18	)	)	-RRB-
cord-257027-q2y7fewk	157	19	.	.	.
cord-257027-q2y7fewk	158	1	Furthermore	furthermore	RB
cord-257027-q2y7fewk	158	2	,	,	,
cord-257027-q2y7fewk	158	3	the	the	DT
cord-257027-q2y7fewk	158	4	influence	influence	NN
cord-257027-q2y7fewk	158	5	of	of	IN
cord-257027-q2y7fewk	158	6	TLR2	TLR2	NNP
cord-257027-q2y7fewk	158	7	and	and	CC
cord-257027-q2y7fewk	158	8	TIRAP	TIRAP	NNP
cord-257027-q2y7fewk	158	9	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	158	10	on	on	IN
cord-257027-q2y7fewk	158	11	clinical	clinical	JJ
cord-257027-q2y7fewk	158	12	disease	disease	NN
cord-257027-q2y7fewk	158	13	caused	cause	VBN
cord-257027-q2y7fewk	158	14	by	by	IN
cord-257027-q2y7fewk	158	15	M.	M.	NNP
cord-257027-q2y7fewk	158	16	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	158	17	has	have	VBZ
cord-257027-q2y7fewk	158	18	been	be	VBN
cord-257027-q2y7fewk	158	19	found	find	VBN
cord-257027-q2y7fewk	158	20	to	to	TO
cord-257027-q2y7fewk	158	21	depend	depend	VB
cord-257027-q2y7fewk	158	22	on	on	IN
cord-257027-q2y7fewk	158	23	pathogen	pathogen	NN
cord-257027-q2y7fewk	158	24	genotypes	genotype	NNS
cord-257027-q2y7fewk	158	25	,	,	,
cord-257027-q2y7fewk	158	26	suggesting	suggest	VBG
cord-257027-q2y7fewk	158	27	the	the	DT
cord-257027-q2y7fewk	158	28	existence	existence	NN
cord-257027-q2y7fewk	158	29	of	of	IN
cord-257027-q2y7fewk	158	30	bacterial	bacterial	JJ
cord-257027-q2y7fewk	158	31	gene	gene	NN
cord-257027-q2y7fewk	158	32	-	-	HYPH
cord-257027-q2y7fewk	158	33	human	human	JJ
cord-257027-q2y7fewk	158	34	gene	gene	NN
cord-257027-q2y7fewk	158	35	interactions	interaction	NNS
cord-257027-q2y7fewk	158	36	(	(	-LRB-
cord-257027-q2y7fewk	158	37	60	60	CD
cord-257027-q2y7fewk	158	38	)	)	-RRB-
cord-257027-q2y7fewk	158	39	.	.	.
cord-257027-q2y7fewk	159	1	Obviwww.bjournal.com.br	Obviwww.bjournal.com.br	NNP
cord-257027-q2y7fewk	159	2	Braz	Braz	NNP
cord-257027-q2y7fewk	159	3	J	J	NNP
cord-257027-q2y7fewk	159	4	Med	Med	NNP
cord-257027-q2y7fewk	159	5	Biol	Biol	NNP
cord-257027-q2y7fewk	159	6	Res	Res	NNP
cord-257027-q2y7fewk	159	7	45	45	CD
cord-257027-q2y7fewk	159	8	(	(	-LRB-
cord-257027-q2y7fewk	159	9	5	5	CD
cord-257027-q2y7fewk	159	10	)	)	-RRB-
cord-257027-q2y7fewk	160	1	2012	2012	CD
cord-257027-q2y7fewk	161	1	ously	ously	NNP
cord-257027-q2y7fewk	161	2	,	,	,
cord-257027-q2y7fewk	161	3	the	the	DT
cord-257027-q2y7fewk	161	4	gene	gene	NN
cord-257027-q2y7fewk	161	5	-	-	HYPH
cord-257027-q2y7fewk	161	6	gene	gene	NN
cord-257027-q2y7fewk	161	7	interaction	interaction	NN
cord-257027-q2y7fewk	161	8	studies	study	NNS
cord-257027-q2y7fewk	161	9	at	at	IN
cord-257027-q2y7fewk	161	10	the	the	DT
cord-257027-q2y7fewk	161	11	genome	genome	NN
cord-257027-q2y7fewk	161	12	scale	scale	NN
cord-257027-q2y7fewk	161	13	pose	pose	VBP
cord-257027-q2y7fewk	161	14	additional	additional	JJ
cord-257027-q2y7fewk	161	15	multitest	multitest	NN
cord-257027-q2y7fewk	161	16	problems	problem	NNS
cord-257027-q2y7fewk	161	17	that	that	WDT
cord-257027-q2y7fewk	161	18	must	must	MD
cord-257027-q2y7fewk	161	19	be	be	VB
cord-257027-q2y7fewk	161	20	tackled	tackle	VBN
cord-257027-q2y7fewk	161	21	.	.	.
cord-257027-q2y7fewk	162	1	In	in	IN
cord-257027-q2y7fewk	162	2	addition	addition	NN
cord-257027-q2y7fewk	162	3	,	,	,
cord-257027-q2y7fewk	162	4	such	such	JJ
cord-257027-q2y7fewk	162	5	approaches	approach	NNS
cord-257027-q2y7fewk	162	6	are	be	VBP
cord-257027-q2y7fewk	162	7	generally	generally	RB
cord-257027-q2y7fewk	162	8	limited	limit	VBN
cord-257027-q2y7fewk	162	9	to	to	IN
cord-257027-q2y7fewk	162	10	low	low	JJ
cord-257027-q2y7fewk	162	11	order	order	NN
cord-257027-q2y7fewk	162	12	interactions	interaction	NNS
cord-257027-q2y7fewk	162	13	,	,	,
cord-257027-q2y7fewk	162	14	and	and	CC
cord-257027-q2y7fewk	162	15	efforts	effort	NNS
cord-257027-q2y7fewk	162	16	are	be	VBP
cord-257027-q2y7fewk	162	17	now	now	RB
cord-257027-q2y7fewk	162	18	needed	need	VBN
cord-257027-q2y7fewk	162	19	to	to	TO
cord-257027-q2y7fewk	162	20	develop	develop	VB
cord-257027-q2y7fewk	162	21	statistical	statistical	JJ
cord-257027-q2y7fewk	162	22	approaches	approach	NNS
cord-257027-q2y7fewk	162	23	that	that	WDT
cord-257027-q2y7fewk	162	24	make	make	VBP
cord-257027-q2y7fewk	162	25	use	use	NN
cord-257027-q2y7fewk	162	26	of	of	IN
cord-257027-q2y7fewk	162	27	the	the	DT
cord-257027-q2y7fewk	162	28	whole	whole	JJ
cord-257027-q2y7fewk	162	29	biological	biological	JJ
cord-257027-q2y7fewk	162	30	network	network	NN
cord-257027-q2y7fewk	162	31	.	.	.
cord-257027-q2y7fewk	163	1	The	the	DT
cord-257027-q2y7fewk	163	2	analysis	analysis	NN
cord-257027-q2y7fewk	163	3	of	of	IN
cord-257027-q2y7fewk	163	4	genetic	genetic	JJ
cord-257027-q2y7fewk	163	5	variation	variation	NN
cord-257027-q2y7fewk	163	6	and	and	CC
cord-257027-q2y7fewk	163	7	gene	gene	NN
cord-257027-q2y7fewk	163	8	expression	expression	NN
cord-257027-q2y7fewk	163	9	levels	level	NNS
cord-257027-q2y7fewk	163	10	could	could	MD
cord-257027-q2y7fewk	163	11	also	also	RB
cord-257027-q2y7fewk	163	12	provide	provide	VB
cord-257027-q2y7fewk	163	13	help	help	NN
cord-257027-q2y7fewk	163	14	in	in	IN
cord-257027-q2y7fewk	163	15	understanding	understand	VBG
cord-257027-q2y7fewk	163	16	how	how	WRB
cord-257027-q2y7fewk	163	17	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	163	18	could	could	MD
cord-257027-q2y7fewk	163	19	perturb	perturb	VB
cord-257027-q2y7fewk	163	20	a	a	DT
cord-257027-q2y7fewk	163	21	transcriptional	transcriptional	JJ
cord-257027-q2y7fewk	163	22	network	network	NN
cord-257027-q2y7fewk	163	23	in	in	IN
cord-257027-q2y7fewk	163	24	infectious	infectious	JJ
cord-257027-q2y7fewk	163	25	diseases	disease	NNS
cord-257027-q2y7fewk	163	26	(	(	-LRB-
cord-257027-q2y7fewk	163	27	61	61	CD
cord-257027-q2y7fewk	163	28	)	)	-RRB-
cord-257027-q2y7fewk	163	29	.	.	.
cord-257027-q2y7fewk	164	1	Microarray	Microarray	NNP
cord-257027-q2y7fewk	164	2	studies	study	NNS
cord-257027-q2y7fewk	164	3	that	that	WDT
cord-257027-q2y7fewk	164	4	are	be	VBP
cord-257027-q2y7fewk	164	5	based	base	VBN
cord-257027-q2y7fewk	164	6	on	on	IN
cord-257027-q2y7fewk	164	7	mice	mouse	NNS
cord-257027-q2y7fewk	164	8	infected	infect	VBN
cord-257027-q2y7fewk	164	9	with	with	IN
cord-257027-q2y7fewk	164	10	either	either	CC
cord-257027-q2y7fewk	164	11	virulent	virulent	JJ
cord-257027-q2y7fewk	164	12	or	or	CC
cord-257027-q2y7fewk	164	13	nonvirulent	nonvirulent	JJ
cord-257027-q2y7fewk	164	14	pathogens	pathogen	NNS
cord-257027-q2y7fewk	164	15	have	have	VBP
cord-257027-q2y7fewk	164	16	identified	identify	VBN
cord-257027-q2y7fewk	164	17	gene	gene	NN
cord-257027-q2y7fewk	164	18	expression	expression	NN
cord-257027-q2y7fewk	164	19	patterns	pattern	NNS
cord-257027-q2y7fewk	164	20	associated	associate	VBN
cord-257027-q2y7fewk	164	21	with	with	IN
cord-257027-q2y7fewk	164	22	some	some	DT
cord-257027-q2y7fewk	164	23	infectious	infectious	JJ
cord-257027-q2y7fewk	164	24	diseases	disease	NNS
cord-257027-q2y7fewk	164	25	,	,	,
cord-257027-q2y7fewk	164	26	indicating	indicate	VBG
cord-257027-q2y7fewk	164	27	the	the	DT
cord-257027-q2y7fewk	164	28	existence	existence	NN
cord-257027-q2y7fewk	164	29	of	of	IN
cord-257027-q2y7fewk	164	30	at	at	RB
cord-257027-q2y7fewk	164	31	least	least	RBS
cord-257027-q2y7fewk	164	32	one	one	CD
cord-257027-q2y7fewk	164	33	transcriptional	transcriptional	JJ
cord-257027-q2y7fewk	164	34	network	network	NN
cord-257027-q2y7fewk	164	35	perturbed	perturb	VBN
cord-257027-q2y7fewk	164	36	by	by	IN
cord-257027-q2y7fewk	164	37	a	a	DT
cord-257027-q2y7fewk	164	38	virulent	virulent	JJ
cord-257027-q2y7fewk	164	39	strain	strain	NN
cord-257027-q2y7fewk	164	40	.	.	.
cord-257027-q2y7fewk	165	1	Moreover	moreover	RB
cord-257027-q2y7fewk	165	2	,	,	,
cord-257027-q2y7fewk	165	3	gene	gene	NN
cord-257027-q2y7fewk	165	4	expression	expression	NN
cord-257027-q2y7fewk	165	5	profiles	profile	NNS
cord-257027-q2y7fewk	165	6	have	have	VBP
cord-257027-q2y7fewk	165	7	been	be	VBN
cord-257027-q2y7fewk	165	8	shown	show	VBN
cord-257027-q2y7fewk	165	9	to	to	TO
cord-257027-q2y7fewk	165	10	discriminate	discriminate	VB
cord-257027-q2y7fewk	165	11	between	between	IN
cord-257027-q2y7fewk	165	12	genetically	genetically	RB
cord-257027-q2y7fewk	165	13	cerebral	cerebral	JJ
cord-257027-q2y7fewk	165	14	malaria	malaria	NN
cord-257027-q2y7fewk	165	15	-	-	HYPH
cord-257027-q2y7fewk	165	16	resistant	resistant	JJ
cord-257027-q2y7fewk	165	17	versus	versus	IN
cord-257027-q2y7fewk	165	18	genetically	genetically	RB
cord-257027-q2y7fewk	165	19	cerebral	cerebral	JJ
cord-257027-q2y7fewk	165	20	malaria	malaria	NN
cord-257027-q2y7fewk	165	21	-	-	HYPH
cord-257027-q2y7fewk	165	22	susceptible	susceptible	JJ
cord-257027-q2y7fewk	165	23	mice	mouse	NNS
cord-257027-q2y7fewk	165	24	at	at	IN
cord-257027-q2y7fewk	165	25	early	early	JJ
cord-257027-q2y7fewk	165	26	and	and	CC
cord-257027-q2y7fewk	165	27	late	late	JJ
cord-257027-q2y7fewk	165	28	stages	stage	NNS
cord-257027-q2y7fewk	165	29	of	of	IN
cord-257027-q2y7fewk	165	30	infection	infection	NN
cord-257027-q2y7fewk	165	31	with	with	IN
cord-257027-q2y7fewk	165	32	P.	P.	NNP
cord-257027-q2y7fewk	165	33	berghei	berghei	NNP
cord-257027-q2y7fewk	165	34	ANKA	ANKA	NNP
cord-257027-q2y7fewk	165	35	(	(	-LRB-
cord-257027-q2y7fewk	165	36	62	62	CD
cord-257027-q2y7fewk	165	37	,	,	,
cord-257027-q2y7fewk	165	38	63	63	CD
cord-257027-q2y7fewk	165	39	)	)	-RRB-
cord-257027-q2y7fewk	165	40	.	.	.
cord-257027-q2y7fewk	166	1	This	this	DT
cord-257027-q2y7fewk	166	2	further	further	RB
cord-257027-q2y7fewk	166	3	indicates	indicate	VBZ
cord-257027-q2y7fewk	166	4	that	that	IN
cord-257027-q2y7fewk	166	5	genetic	genetic	JJ
cord-257027-q2y7fewk	166	6	variants	variant	NNS
cord-257027-q2y7fewk	166	7	direct	direct	RB
cord-257027-q2y7fewk	166	8	at	at	RB
cord-257027-q2y7fewk	166	9	least	least	RBS
cord-257027-q2y7fewk	166	10	one	one	CD
cord-257027-q2y7fewk	166	11	transcriptional	transcriptional	JJ
cord-257027-q2y7fewk	166	12	network	network	NN
cord-257027-q2y7fewk	166	13	towards	towards	IN
cord-257027-q2y7fewk	166	14	a	a	DT
cord-257027-q2y7fewk	166	15	state	state	NN
cord-257027-q2y7fewk	166	16	conducting	conduct	VBG
cord-257027-q2y7fewk	166	17	to	to	IN
cord-257027-q2y7fewk	166	18	cerebral	cerebral	JJ
cord-257027-q2y7fewk	166	19	malaria	malaria	NN
cord-257027-q2y7fewk	166	20	and	and	CC
cord-257027-q2y7fewk	166	21	death	death	NN
cord-257027-q2y7fewk	166	22	in	in	IN
cord-257027-q2y7fewk	166	23	susceptible	susceptible	JJ
cord-257027-q2y7fewk	166	24	mice	mouse	NNS
cord-257027-q2y7fewk	166	25	after	after	IN
cord-257027-q2y7fewk	166	26	infection	infection	NN
cord-257027-q2y7fewk	166	27	.	.	.
cord-257027-q2y7fewk	167	1	In	in	IN
cord-257027-q2y7fewk	167	2	humans	human	NNS
cord-257027-q2y7fewk	167	3	,	,	,
cord-257027-q2y7fewk	167	4	blood	blood	NN
cord-257027-q2y7fewk	167	5	cell	cell	NN
cord-257027-q2y7fewk	167	6	gene	gene	NN
cord-257027-q2y7fewk	167	7	expression	expression	NN
cord-257027-q2y7fewk	167	8	profiles	profile	NNS
cord-257027-q2y7fewk	167	9	have	have	VBP
cord-257027-q2y7fewk	167	10	been	be	VBN
cord-257027-q2y7fewk	167	11	associated	associate	VBN
cord-257027-q2y7fewk	167	12	with	with	IN
cord-257027-q2y7fewk	167	13	the	the	DT
cord-257027-q2y7fewk	167	14	clinical	clinical	JJ
cord-257027-q2y7fewk	167	15	status	status	NN
cord-257027-q2y7fewk	167	16	of	of	IN
cord-257027-q2y7fewk	167	17	patients	patient	NNS
cord-257027-q2y7fewk	167	18	infected	infect	VBN
cord-257027-q2y7fewk	167	19	with	with	IN
cord-257027-q2y7fewk	167	20	different	different	JJ
cord-257027-q2y7fewk	167	21	pathogens	pathogen	NNS
cord-257027-q2y7fewk	167	22	(	(	-LRB-
cord-257027-q2y7fewk	167	23	64	64	CD
cord-257027-q2y7fewk	167	24	)	)	-RRB-
cord-257027-q2y7fewk	167	25	,	,	,
cord-257027-q2y7fewk	167	26	and	and	CC
cord-257027-q2y7fewk	167	27	have	have	VBP
cord-257027-q2y7fewk	167	28	been	be	VBN
cord-257027-q2y7fewk	167	29	used	use	VBN
cord-257027-q2y7fewk	167	30	to	to	TO
cord-257027-q2y7fewk	167	31	monitor	monitor	VB
cord-257027-q2y7fewk	167	32	the	the	DT
cord-257027-q2y7fewk	167	33	response	response	NN
cord-257027-q2y7fewk	167	34	to	to	IN
cord-257027-q2y7fewk	167	35	BCG	BCG	NNP
cord-257027-q2y7fewk	167	36	vaccination	vaccination	NN
cord-257027-q2y7fewk	167	37	in	in	IN
cord-257027-q2y7fewk	167	38	children	child	NNS
cord-257027-q2y7fewk	167	39	(	(	-LRB-
cord-257027-q2y7fewk	167	40	65	65	CD
cord-257027-q2y7fewk	167	41	)	)	-RRB-
cord-257027-q2y7fewk	167	42	.	.	.
cord-257027-q2y7fewk	168	1	Although	although	IN
cord-257027-q2y7fewk	168	2	very	very	RB
cord-257027-q2y7fewk	168	3	few	few	JJ
cord-257027-q2y7fewk	168	4	genomic	genomic	JJ
cord-257027-q2y7fewk	168	5	studies	study	NNS
cord-257027-q2y7fewk	168	6	have	have	VBP
cord-257027-q2y7fewk	168	7	been	be	VBN
cord-257027-q2y7fewk	168	8	performed	perform	VBN
cord-257027-q2y7fewk	168	9	in	in	IN
cord-257027-q2y7fewk	168	10	the	the	DT
cord-257027-q2y7fewk	168	11	field	field	NN
cord-257027-q2y7fewk	168	12	of	of	IN
cord-257027-q2y7fewk	168	13	vaccination	vaccination	NN
cord-257027-q2y7fewk	168	14	it	-PRON-	PRP
cord-257027-q2y7fewk	168	15	has	have	VBZ
cord-257027-q2y7fewk	168	16	been	be	VBN
cord-257027-q2y7fewk	168	17	anticipated	anticipate	VBN
cord-257027-q2y7fewk	168	18	that	that	IN
cord-257027-q2y7fewk	168	19	the	the	DT
cord-257027-q2y7fewk	168	20	biological	biological	JJ
cord-257027-q2y7fewk	168	21	network	network	NN
cord-257027-q2y7fewk	168	22	concept	concept	NN
cord-257027-q2y7fewk	168	23	would	would	MD
cord-257027-q2y7fewk	168	24	be	be	VB
cord-257027-q2y7fewk	168	25	useful	useful	JJ
cord-257027-q2y7fewk	168	26	.	.	.
cord-257027-q2y7fewk	169	1	In	in	IN
cord-257027-q2y7fewk	169	2	this	this	DT
cord-257027-q2y7fewk	169	3	way	way	NN
cord-257027-q2y7fewk	169	4	,	,	,
cord-257027-q2y7fewk	169	5	Poland	Poland	NNP
cord-257027-q2y7fewk	169	6	et	et	NNP
cord-257027-q2y7fewk	169	7	al	al	NNP
cord-257027-q2y7fewk	169	8	.	.	.
cord-257027-q2y7fewk	170	1	(	(	-LRB-
cord-257027-q2y7fewk	170	2	44	44	CD
cord-257027-q2y7fewk	170	3	)	)	-RRB-
cord-257027-q2y7fewk	170	4	proposed	propose	VBD
cord-257027-q2y7fewk	170	5	"	"	``
cord-257027-q2y7fewk	170	6	the	the	DT
cord-257027-q2y7fewk	170	7	immuneresponse	immuneresponse	NNP
cord-257027-q2y7fewk	170	8	network	network	NN
cord-257027-q2y7fewk	170	9	theory	theory	NN
cord-257027-q2y7fewk	170	10	"	"	''
cord-257027-q2y7fewk	170	11	,	,	,
cord-257027-q2y7fewk	170	12	whereby	whereby	WRB
cord-257027-q2y7fewk	170	13	the	the	DT
cord-257027-q2y7fewk	170	14	response	response	NN
cord-257027-q2y7fewk	170	15	to	to	IN
cord-257027-q2y7fewk	170	16	the	the	DT
cord-257027-q2y7fewk	170	17	vaccine	vaccine	NN
cord-257027-q2y7fewk	170	18	can	can	MD
cord-257027-q2y7fewk	170	19	be	be	VB
cord-257027-q2y7fewk	170	20	viewed	view	VBN
cord-257027-q2y7fewk	170	21	as	as	IN
cord-257027-q2y7fewk	170	22	the	the	DT
cord-257027-q2y7fewk	170	23	cumulative	cumulative	JJ
cord-257027-q2y7fewk	170	24	result	result	NN
cord-257027-q2y7fewk	170	25	of	of	IN
cord-257027-q2y7fewk	170	26	gene	gene	NN
cord-257027-q2y7fewk	170	27	interactions	interaction	NNS
cord-257027-q2y7fewk	170	28	.	.	.
cord-257027-q2y7fewk	171	1	The	the	DT
cord-257027-q2y7fewk	171	2	findings	finding	NNS
cord-257027-q2y7fewk	171	3	in	in	IN
cord-257027-q2y7fewk	171	4	naturally	naturally	RB
cord-257027-q2y7fewk	171	5	infected	infect	VBN
cord-257027-q2y7fewk	171	6	individuals	individual	NNS
cord-257027-q2y7fewk	171	7	and	and	CC
cord-257027-q2y7fewk	171	8	in	in	IN
cord-257027-q2y7fewk	171	9	mouse	mouse	NN
cord-257027-q2y7fewk	171	10	models	model	NNS
cord-257027-q2y7fewk	171	11	of	of	IN
cord-257027-q2y7fewk	171	12	infectious	infectious	JJ
cord-257027-q2y7fewk	171	13	diseases	disease	NNS
cord-257027-q2y7fewk	171	14	support	support	VBP
cord-257027-q2y7fewk	171	15	this	this	DT
cord-257027-q2y7fewk	171	16	hypothesis	hypothesis	NN
cord-257027-q2y7fewk	171	17	.	.	.
cord-257027-q2y7fewk	172	1	This	this	DT
cord-257027-q2y7fewk	172	2	urges	urge	VBZ
cord-257027-q2y7fewk	172	3	the	the	DT
cord-257027-q2y7fewk	172	4	effort	effort	NN
cord-257027-q2y7fewk	172	5	to	to	TO
cord-257027-q2y7fewk	172	6	perform	perform	VB
cord-257027-q2y7fewk	172	7	genome	genome	NN
cord-257027-q2y7fewk	172	8	-	-	HYPH
cord-257027-q2y7fewk	172	9	wide	wide	JJ
cord-257027-q2y7fewk	172	10	studies	study	NNS
cord-257027-q2y7fewk	172	11	in	in	IN
cord-257027-q2y7fewk	172	12	vaccinated	vaccinated	JJ
cord-257027-q2y7fewk	172	13	mice	mouse	NNS
cord-257027-q2y7fewk	172	14	and	and	CC
cord-257027-q2y7fewk	172	15	humans	human	NNS
cord-257027-q2y7fewk	172	16	,	,	,
cord-257027-q2y7fewk	172	17	and	and	CC
cord-257027-q2y7fewk	172	18	to	to	TO
cord-257027-q2y7fewk	172	19	compare	compare	VB
cord-257027-q2y7fewk	172	20	the	the	DT
cord-257027-q2y7fewk	172	21	results	result	NNS
cord-257027-q2y7fewk	172	22	with	with	IN
cord-257027-q2y7fewk	172	23	those	those	DT
cord-257027-q2y7fewk	172	24	obtained	obtain	VBN
cord-257027-q2y7fewk	172	25	in	in	IN
cord-257027-q2y7fewk	172	26	natural	natural	JJ
cord-257027-q2y7fewk	172	27	infections	infection	NNS
cord-257027-q2y7fewk	172	28	.	.	.
cord-257027-q2y7fewk	173	1	The	the	DT
cord-257027-q2y7fewk	173	2	same	same	JJ
cord-257027-q2y7fewk	173	3	authors	author	NNS
cord-257027-q2y7fewk	173	4	have	have	VBP
cord-257027-q2y7fewk	173	5	suggested	suggest	VBN
cord-257027-q2y7fewk	173	6	that	that	IN
cord-257027-q2y7fewk	173	7	the	the	DT
cord-257027-q2y7fewk	173	8	network	network	NN
cord-257027-q2y7fewk	173	9	combined	combine	VBN
cord-257027-q2y7fewk	173	10	with	with	IN
cord-257027-q2y7fewk	173	11	individual	individual	JJ
cord-257027-q2y7fewk	173	12	genomic	genomic	JJ
cord-257027-q2y7fewk	173	13	profiles	profile	NNS
cord-257027-q2y7fewk	173	14	may	may	MD
cord-257027-q2y7fewk	173	15	lead	lead	VB
cord-257027-q2y7fewk	173	16	to	to	IN
cord-257027-q2y7fewk	173	17	predicting	predict	VBG
cord-257027-q2y7fewk	173	18	the	the	DT
cord-257027-q2y7fewk	173	19	response	response	NN
cord-257027-q2y7fewk	173	20	to	to	IN
cord-257027-q2y7fewk	173	21	vaccination	vaccination	NN
cord-257027-q2y7fewk	173	22	.	.	.
cord-257027-q2y7fewk	174	1	This	this	DT
cord-257027-q2y7fewk	174	2	is	be	VBZ
cord-257027-q2y7fewk	174	3	a	a	DT
cord-257027-q2y7fewk	174	4	big	big	JJ
cord-257027-q2y7fewk	174	5	challenge	challenge	NN
cord-257027-q2y7fewk	174	6	because	because	IN
cord-257027-q2y7fewk	174	7	it	-PRON-	PRP
cord-257027-q2y7fewk	174	8	will	will	MD
cord-257027-q2y7fewk	174	9	require	require	VB
cord-257027-q2y7fewk	174	10	biological	biological	JJ
cord-257027-q2y7fewk	174	11	networks	network	NNS
cord-257027-q2y7fewk	174	12	that	that	WDT
cord-257027-q2y7fewk	174	13	capture	capture	VBP
cord-257027-q2y7fewk	174	14	all	all	PDT
cord-257027-q2y7fewk	174	15	the	the	DT
cord-257027-q2y7fewk	174	16	relevant	relevant	JJ
cord-257027-q2y7fewk	174	17	information	information	NN
cord-257027-q2y7fewk	174	18	,	,	,
cord-257027-q2y7fewk	174	19	including	include	VBG
cord-257027-q2y7fewk	174	20	the	the	DT
cord-257027-q2y7fewk	174	21	effect	effect	NN
cord-257027-q2y7fewk	174	22	of	of	IN
cord-257027-q2y7fewk	174	23	genetic	genetic	JJ
cord-257027-q2y7fewk	174	24	and	and	CC
cord-257027-q2y7fewk	174	25	other	other	JJ
cord-257027-q2y7fewk	174	26	biological	biological	JJ
cord-257027-q2y7fewk	174	27	information	information	NN
cord-257027-q2y7fewk	174	28	(	(	-LRB-
cord-257027-q2y7fewk	174	29	age	age	NN
cord-257027-q2y7fewk	174	30	,	,	,
cord-257027-q2y7fewk	174	31	gender	gender	NN
cord-257027-q2y7fewk	174	32	,	,	,
cord-257027-q2y7fewk	174	33	etc	etc	FW
cord-257027-q2y7fewk	174	34	.	.	.
cord-257027-q2y7fewk	174	35	)	)	-RRB-
cord-257027-q2y7fewk	174	36	.	.	.
cord-257027-q2y7fewk	175	1	This	this	DT
cord-257027-q2y7fewk	175	2	further	further	RB
cord-257027-q2y7fewk	175	3	implies	imply	VBZ
cord-257027-q2y7fewk	175	4	that	that	IN
cord-257027-q2y7fewk	175	5	one	one	PRP
cord-257027-q2y7fewk	175	6	would	would	MD
cord-257027-q2y7fewk	175	7	be	be	VB
cord-257027-q2y7fewk	175	8	able	able	JJ
cord-257027-q2y7fewk	175	9	to	to	TO
cord-257027-q2y7fewk	175	10	predict	predict	VB
cord-257027-q2y7fewk	175	11	the	the	DT
cord-257027-q2y7fewk	175	12	effect	effect	NN
cord-257027-q2y7fewk	175	13	of	of	IN
cord-257027-q2y7fewk	175	14	single	single	JJ
cord-257027-q2y7fewk	175	15	or	or	CC
cord-257027-q2y7fewk	175	16	combined	combine	VBN
cord-257027-q2y7fewk	175	17	perturbations	perturbation	NNS
cord-257027-q2y7fewk	175	18	such	such	JJ
cord-257027-q2y7fewk	175	19	as	as	IN
cord-257027-q2y7fewk	175	20	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	175	21	on	on	IN
cord-257027-q2y7fewk	175	22	molecular	molecular	JJ
cord-257027-q2y7fewk	175	23	phenotypes	phenotype	NNS
cord-257027-q2y7fewk	175	24	(	(	-LRB-
cord-257027-q2y7fewk	175	25	Figure	figure	NN
cord-257027-q2y7fewk	175	26	2	2	CD
cord-257027-q2y7fewk	175	27	)	)	-RRB-
cord-257027-q2y7fewk	175	28	.	.	.
cord-257027-q2y7fewk	176	1	For	for	IN
cord-257027-q2y7fewk	176	2	this	this	DT
cord-257027-q2y7fewk	176	3	pur	pur	NN
cord-257027-q2y7fewk	176	4	-	-	JJ
cord-257027-q2y7fewk	176	5	pose	pose	JJ
cord-257027-q2y7fewk	176	6	,	,	,
cord-257027-q2y7fewk	176	7	regulatory	regulatory	JJ
cord-257027-q2y7fewk	176	8	network	network	NN
cord-257027-q2y7fewk	176	9	modeling	modeling	NN
cord-257027-q2y7fewk	176	10	methods	method	NNS
cord-257027-q2y7fewk	176	11	would	would	MD
cord-257027-q2y7fewk	176	12	be	be	VB
cord-257027-q2y7fewk	176	13	useful	useful	JJ
cord-257027-q2y7fewk	176	14	:	:	:
cord-257027-q2y7fewk	176	15	models	model	NNS
cord-257027-q2y7fewk	176	16	constructed	construct	VBN
cord-257027-q2y7fewk	176	17	on	on	IN
cord-257027-q2y7fewk	176	18	available	available	JJ
cord-257027-q2y7fewk	176	19	data	datum	NNS
cord-257027-q2y7fewk	176	20	to	to	TO
cord-257027-q2y7fewk	176	21	predict	predict	VB
cord-257027-q2y7fewk	176	22	molecular	molecular	JJ
cord-257027-q2y7fewk	176	23	and	and	CC
cord-257027-q2y7fewk	176	24	cellular	cellular	JJ
cord-257027-q2y7fewk	176	25	phenotypes	phenotype	NNS
cord-257027-q2y7fewk	176	26	will	will	MD
cord-257027-q2y7fewk	176	27	provide	provide	VB
cord-257027-q2y7fewk	176	28	working	work	VBG
cord-257027-q2y7fewk	176	29	hypotheses	hypothesis	NNS
cord-257027-q2y7fewk	176	30	that	that	WDT
cord-257027-q2y7fewk	176	31	can	can	MD
cord-257027-q2y7fewk	176	32	be	be	VB
cord-257027-q2y7fewk	176	33	tested	test	VBN
cord-257027-q2y7fewk	176	34	,	,	,
cord-257027-q2y7fewk	176	35	leading	lead	VBG
cord-257027-q2y7fewk	176	36	to	to	IN
cord-257027-q2y7fewk	176	37	the	the	DT
cord-257027-q2y7fewk	176	38	improvement	improvement	NN
cord-257027-q2y7fewk	176	39	of	of	IN
cord-257027-q2y7fewk	176	40	the	the	DT
cord-257027-q2y7fewk	176	41	initial	initial	JJ
cord-257027-q2y7fewk	176	42	model	model	NN
cord-257027-q2y7fewk	176	43	.	.	.
cord-257027-q2y7fewk	177	1	Interestingly	interestingly	RB
cord-257027-q2y7fewk	177	2	,	,	,
cord-257027-q2y7fewk	177	3	immune	immune	JJ
cord-257027-q2y7fewk	177	4	response	response	NN
cord-257027-q2y7fewk	177	5	system	system	NN
cord-257027-q2y7fewk	177	6	-	-	HYPH
cord-257027-q2y7fewk	177	7	level	level	NN
cord-257027-q2y7fewk	177	8	tools	tool	NNS
cord-257027-q2y7fewk	177	9	have	have	VBP
cord-257027-q2y7fewk	177	10	been	be	VBN
cord-257027-q2y7fewk	177	11	made	make	VBN
cord-257027-q2y7fewk	177	12	available	available	JJ
cord-257027-q2y7fewk	177	13	(	(	-LRB-
cord-257027-q2y7fewk	177	14	66	66	CD
cord-257027-q2y7fewk	177	15	)	)	-RRB-
cord-257027-q2y7fewk	177	16	.	.	.
cord-257027-q2y7fewk	178	1	Thus	thus	RB
cord-257027-q2y7fewk	178	2	,	,	,
cord-257027-q2y7fewk	178	3	Systems	Systems	NNP
cord-257027-q2y7fewk	178	4	Biology	Biology	NNP
cord-257027-q2y7fewk	178	5	is	be	VBZ
cord-257027-q2y7fewk	178	6	a	a	DT
cord-257027-q2y7fewk	178	7	new	new	JJ
cord-257027-q2y7fewk	178	8	rational	rational	JJ
cord-257027-q2y7fewk	178	9	approach	approach	NN
cord-257027-q2y7fewk	178	10	that	that	WDT
cord-257027-q2y7fewk	178	11	gives	give	VBZ
cord-257027-q2y7fewk	178	12	a	a	DT
cord-257027-q2y7fewk	178	13	more	more	RBR
cord-257027-q2y7fewk	178	14	comprehensive	comprehensive	JJ
cord-257027-q2y7fewk	178	15	understanding	understanding	NN
cord-257027-q2y7fewk	178	16	of	of	IN
cord-257027-q2y7fewk	178	17	networks	network	NNS
cord-257027-q2y7fewk	178	18	or	or	CC
cord-257027-q2y7fewk	178	19	interacting	interact	VBG
cord-257027-q2y7fewk	178	20	components	component	NNS
cord-257027-q2y7fewk	178	21	in	in	IN
cord-257027-q2y7fewk	178	22	the	the	DT
cord-257027-q2y7fewk	178	23	immune	immune	JJ
cord-257027-q2y7fewk	178	24	response	response	NN
cord-257027-q2y7fewk	178	25	to	to	IN
cord-257027-q2y7fewk	178	26	pathogen	pathogen	NN
cord-257027-q2y7fewk	178	27	antigens	antigen	NNS
cord-257027-q2y7fewk	178	28	.	.	.
cord-257027-q2y7fewk	179	1	This	this	DT
cord-257027-q2y7fewk	179	2	concept	concept	NN
cord-257027-q2y7fewk	179	3	has	have	VBZ
cord-257027-q2y7fewk	179	4	been	be	VBN
cord-257027-q2y7fewk	179	5	recently	recently	RB
cord-257027-q2y7fewk	179	6	reviewed	review	VBN
cord-257027-q2y7fewk	179	7	(	(	-LRB-
cord-257027-q2y7fewk	179	8	67	67	CD
cord-257027-q2y7fewk	179	9	)	)	-RRB-
cord-257027-q2y7fewk	179	10	.	.	.
cord-257027-q2y7fewk	180	1	It	-PRON-	PRP
cord-257027-q2y7fewk	180	2	can	can	MD
cord-257027-q2y7fewk	180	3	be	be	VB
cord-257027-q2y7fewk	180	4	applied	apply	VBN
cord-257027-q2y7fewk	180	5	to	to	TO
cord-257027-q2y7fewk	180	6	identify	identify	VB
cord-257027-q2y7fewk	180	7	signatures	signature	NNS
cord-257027-q2y7fewk	180	8	of	of	IN
cord-257027-q2y7fewk	180	9	protection	protection	NN
cord-257027-q2y7fewk	180	10	that	that	WDT
cord-257027-q2y7fewk	180	11	would	would	MD
cord-257027-q2y7fewk	180	12	be	be	VB
cord-257027-q2y7fewk	180	13	evaluated	evaluate	VBN
cord-257027-q2y7fewk	180	14	in	in	IN
cord-257027-q2y7fewk	180	15	the	the	DT
cord-257027-q2y7fewk	180	16	de-	de-	NN
cord-257027-q2y7fewk	180	17	Vaccinomics	Vaccinomics	NNP
cord-257027-q2y7fewk	180	18	)	)	-RRB-
cord-257027-q2y7fewk	180	19	.	.	.
cord-257027-q2y7fewk	181	1	This	this	DT
cord-257027-q2y7fewk	181	2	emergent	emergent	JJ
cord-257027-q2y7fewk	181	3	research	research	NN
cord-257027-q2y7fewk	181	4	strategy	strategy	NN
cord-257027-q2y7fewk	181	5	in	in	IN
cord-257027-q2y7fewk	181	6	vaccine	vaccine	NN
cord-257027-q2y7fewk	181	7	development	development	NN
cord-257027-q2y7fewk	181	8	was	be	VBD
cord-257027-q2y7fewk	181	9	already	already	RB
cord-257027-q2y7fewk	181	10	applied	apply	VBN
cord-257027-q2y7fewk	181	11	to	to	TO
cord-257027-q2y7fewk	181	12	identify	identify	VB
cord-257027-q2y7fewk	181	13	signatures	signature	NNS
cord-257027-q2y7fewk	181	14	of	of	IN
cord-257027-q2y7fewk	181	15	protection	protection	NN
cord-257027-q2y7fewk	181	16	to	to	IN
cord-257027-q2y7fewk	181	17	influenza	influenza	NN
cord-257027-q2y7fewk	181	18	(	(	-LRB-
cord-257027-q2y7fewk	181	19	68	68	CD
cord-257027-q2y7fewk	181	20	)	)	-RRB-
cord-257027-q2y7fewk	181	21	and	and	CC
cord-257027-q2y7fewk	181	22	yellow	yellow	JJ
cord-257027-q2y7fewk	181	23	fever	fever	NN
cord-257027-q2y7fewk	181	24	vaccines	vaccine	NNS
cord-257027-q2y7fewk	181	25	(	(	-LRB-
cord-257027-q2y7fewk	181	26	69	69	CD
cord-257027-q2y7fewk	181	27	)	)	-RRB-
cord-257027-q2y7fewk	181	28	.	.	.
cord-257027-q2y7fewk	182	1	Nevertheless	nevertheless	RB
cord-257027-q2y7fewk	182	2	,	,	,
cord-257027-q2y7fewk	182	3	the	the	DT
cord-257027-q2y7fewk	182	4	current	current	JJ
cord-257027-q2y7fewk	182	5	tools	tool	NNS
cord-257027-q2y7fewk	182	6	can	can	MD
cord-257027-q2y7fewk	182	7	manage	manage	VB
cord-257027-q2y7fewk	182	8	small	small	JJ
cord-257027-q2y7fewk	182	9	biological	biological	JJ
cord-257027-q2y7fewk	182	10	networks	network	NNS
cord-257027-q2y7fewk	182	11	;	;	:
cord-257027-q2y7fewk	182	12	the	the	DT
cord-257027-q2y7fewk	182	13	challenge	challenge	NN
cord-257027-q2y7fewk	182	14	is	be	VBZ
cord-257027-q2y7fewk	182	15	to	to	TO
cord-257027-q2y7fewk	182	16	develop	develop	VB
cord-257027-q2y7fewk	182	17	new	new	JJ
cord-257027-q2y7fewk	182	18	approaches	approach	NNS
cord-257027-q2y7fewk	182	19	that	that	WDT
cord-257027-q2y7fewk	182	20	allow	allow	VBP
cord-257027-q2y7fewk	182	21	the	the	DT
cord-257027-q2y7fewk	182	22	modeling	modeling	NN
cord-257027-q2y7fewk	182	23	of	of	IN
cord-257027-q2y7fewk	182	24	large	large	JJ
cord-257027-q2y7fewk	182	25	regulatory	regulatory	JJ
cord-257027-q2y7fewk	182	26	networks	network	NNS
cord-257027-q2y7fewk	182	27	.	.	.
cord-257027-q2y7fewk	183	1	In	in	IN
cord-257027-q2y7fewk	183	2	conclusion	conclusion	NN
cord-257027-q2y7fewk	183	3	,	,	,
cord-257027-q2y7fewk	183	4	genomics	genomic	NNS
cord-257027-q2y7fewk	183	5	of	of	IN
cord-257027-q2y7fewk	183	6	infectious	infectious	JJ
cord-257027-q2y7fewk	183	7	agents	agent	NNS
cord-257027-q2y7fewk	183	8	will	will	MD
cord-257027-q2y7fewk	183	9	accelerate	accelerate	VB
cord-257027-q2y7fewk	183	10	the	the	DT
cord-257027-q2y7fewk	183	11	identification	identification	NN
cord-257027-q2y7fewk	183	12	of	of	IN
cord-257027-q2y7fewk	183	13	new	new	JJ
cord-257027-q2y7fewk	183	14	relevant	relevant	JJ
cord-257027-q2y7fewk	183	15	vaccine	vaccine	NN
cord-257027-q2y7fewk	183	16	candidate	candidate	NN
cord-257027-q2y7fewk	183	17	antigens	antigen	NNS
cord-257027-q2y7fewk	183	18	,	,	,
cord-257027-q2y7fewk	183	19	including	include	VBG
cord-257027-q2y7fewk	183	20	antigens	antigen	NNS
cord-257027-q2y7fewk	183	21	that	that	WDT
cord-257027-q2y7fewk	183	22	are	be	VBP
cord-257027-q2y7fewk	183	23	conserved	conserve	VBN
cord-257027-q2y7fewk	183	24	between	between	IN
cord-257027-q2y7fewk	183	25	strains	strain	NNS
cord-257027-q2y7fewk	183	26	or	or	CC
cord-257027-q2y7fewk	183	27	collectively	collectively	RB
cord-257027-q2y7fewk	183	28	cover	cover	VB
cord-257027-q2y7fewk	183	29	the	the	DT
cord-257027-q2y7fewk	183	30	diversity	diversity	NN
cord-257027-q2y7fewk	183	31	of	of	IN
cord-257027-q2y7fewk	183	32	strains	strain	NNS
cord-257027-q2y7fewk	183	33	and	and	CC
cord-257027-q2y7fewk	183	34	that	that	WDT
cord-257027-q2y7fewk	183	35	are	be	VBP
cord-257027-q2y7fewk	183	36	the	the	DT
cord-257027-q2y7fewk	183	37	targets	target	NNS
cord-257027-q2y7fewk	183	38	of	of	IN
cord-257027-q2y7fewk	183	39	protective	protective	JJ
cord-257027-q2y7fewk	183	40	immune	immune	JJ
cord-257027-q2y7fewk	183	41	responses	response	NNS
cord-257027-q2y7fewk	183	42	.	.	.
cord-257027-q2y7fewk	184	1	The	the	DT
cord-257027-q2y7fewk	184	2	genome	genome	NN
cord-257027-q2y7fewk	184	3	-	-	HYPH
cord-257027-q2y7fewk	184	4	based	base	VBN
cord-257027-q2y7fewk	184	5	approaches	approach	NNS
cord-257027-q2y7fewk	184	6	should	should	MD
cord-257027-q2y7fewk	184	7	help	help	VB
cord-257027-q2y7fewk	184	8	in	in	IN
cord-257027-q2y7fewk	184	9	developing	develop	VBG
cord-257027-q2y7fewk	184	10	vaccines	vaccine	NNS
cord-257027-q2y7fewk	184	11	against	against	IN
cord-257027-q2y7fewk	184	12	old	old	JJ
cord-257027-q2y7fewk	184	13	,	,	,
cord-257027-q2y7fewk	184	14	but	but	CC
cord-257027-q2y7fewk	184	15	so	so	RB
cord-257027-q2y7fewk	184	16	far	far	RB
cord-257027-q2y7fewk	184	17	uncontrolled	uncontrolled	JJ
cord-257027-q2y7fewk	184	18	,	,	,
cord-257027-q2y7fewk	184	19	infectious	infectious	JJ
cord-257027-q2y7fewk	184	20	diseases	disease	NNS
cord-257027-q2y7fewk	184	21	that	that	WDT
cord-257027-q2y7fewk	184	22	are	be	VBP
cord-257027-q2y7fewk	184	23	expected	expect	VBN
cord-257027-q2y7fewk	184	24	in	in	IN
cord-257027-q2y7fewk	184	25	developing	develop	VBG
cord-257027-q2y7fewk	184	26	countries	country	NNS
cord-257027-q2y7fewk	184	27	,	,	,
cord-257027-q2y7fewk	184	28	and	and	CC
cord-257027-q2y7fewk	184	29	may	may	MD
cord-257027-q2y7fewk	184	30	play	play	VB
cord-257027-q2y7fewk	184	31	a	a	DT
cord-257027-q2y7fewk	184	32	critical	critical	JJ
cord-257027-q2y7fewk	184	33	role	role	NN
cord-257027-q2y7fewk	184	34	in	in	IN
cord-257027-q2y7fewk	184	35	the	the	DT
cord-257027-q2y7fewk	184	36	design	design	NN
cord-257027-q2y7fewk	184	37	of	of	IN
cord-257027-q2y7fewk	184	38	vaccines	vaccine	NNS
cord-257027-q2y7fewk	184	39	against	against	IN
cord-257027-q2y7fewk	184	40	emerging	emerge	VBG
cord-257027-q2y7fewk	184	41	infectious	infectious	JJ
cord-257027-q2y7fewk	184	42	diseases	disease	NNS
cord-257027-q2y7fewk	184	43	as	as	RB
cord-257027-q2y7fewk	184	44	well	well	RB
cord-257027-q2y7fewk	184	45	as	as	IN
cord-257027-q2y7fewk	184	46	non	non	JJ
cord-257027-q2y7fewk	184	47	-	-	JJ
cord-257027-q2y7fewk	184	48	infectious	infectious	JJ
cord-257027-q2y7fewk	184	49	diseases	disease	NNS
cord-257027-q2y7fewk	184	50	.	.	.
cord-257027-q2y7fewk	185	1	The	the	DT
cord-257027-q2y7fewk	185	2	identification	identification	NN
cord-257027-q2y7fewk	185	3	of	of	IN
cord-257027-q2y7fewk	185	4	relevant	relevant	JJ
cord-257027-q2y7fewk	185	5	molecular	molecular	JJ
cord-257027-q2y7fewk	185	6	targets	target	NNS
cord-257027-q2y7fewk	185	7	will	will	MD
cord-257027-q2y7fewk	185	8	require	require	VB
cord-257027-q2y7fewk	185	9	further	further	JJ
cord-257027-q2y7fewk	185	10	research	research	NN
cord-257027-q2y7fewk	185	11	on	on	IN
cord-257027-q2y7fewk	185	12	protective	protective	JJ
cord-257027-q2y7fewk	185	13	immune	immune	JJ
cord-257027-q2y7fewk	185	14	responses	response	NNS
cord-257027-q2y7fewk	185	15	and	and	CC
cord-257027-q2y7fewk	185	16	the	the	DT
cord-257027-q2y7fewk	185	17	development	development	NN
cord-257027-q2y7fewk	185	18	of	of	IN
cord-257027-q2y7fewk	185	19	immunological	immunological	JJ
cord-257027-q2y7fewk	185	20	tools	tool	NNS
cord-257027-q2y7fewk	185	21	.	.	.
cord-257027-q2y7fewk	186	1	Recent	recent	JJ
cord-257027-q2y7fewk	186	2	investigations	investigation	NNS
cord-257027-q2y7fewk	186	3	that	that	WDT
cord-257027-q2y7fewk	186	4	have	have	VBP
cord-257027-q2y7fewk	186	5	systematically	systematically	RB
cord-257027-q2y7fewk	186	6	searched	search	VBN
cord-257027-q2y7fewk	186	7	for	for	IN
cord-257027-q2y7fewk	186	8	viral	viral	JJ
cord-257027-q2y7fewk	186	9	protein	protein	NN
cord-257027-q2y7fewk	186	10	-	-	HYPH
cord-257027-q2y7fewk	186	11	human	human	JJ
cord-257027-q2y7fewk	186	12	protein	protein	NN
cord-257027-q2y7fewk	186	13	interactions	interaction	NNS
cord-257027-q2y7fewk	186	14	open	open	VBP
cord-257027-q2y7fewk	186	15	new	new	JJ
cord-257027-q2y7fewk	186	16	avenues	avenue	NNS
cord-257027-q2y7fewk	186	17	for	for	IN
cord-257027-q2y7fewk	186	18	understanding	understand	VBG
cord-257027-q2y7fewk	186	19	host	host	NN
cord-257027-q2y7fewk	186	20	-	-	HYPH
cord-257027-q2y7fewk	186	21	pathogen	pathogen	NN
cord-257027-q2y7fewk	186	22	interactions	interaction	NNS
cord-257027-q2y7fewk	186	23	and	and	CC
cord-257027-q2y7fewk	186	24	therapeutic	therapeutic	JJ
cord-257027-q2y7fewk	186	25	strategies	strategy	NNS
cord-257027-q2y7fewk	186	26	.	.	.
cord-257027-q2y7fewk	187	1	Further	further	JJ
cord-257027-q2y7fewk	187	2	research	research	NN
cord-257027-q2y7fewk	187	3	on	on	IN
cord-257027-q2y7fewk	187	4	the	the	DT
cord-257027-q2y7fewk	187	5	mechanisms	mechanism	NNS
cord-257027-q2y7fewk	187	6	of	of	IN
cord-257027-q2y7fewk	187	7	action	action	NN
cord-257027-q2y7fewk	187	8	of	of	IN
cord-257027-q2y7fewk	187	9	adjuvants	adjuvant	NNS
cord-257027-q2y7fewk	187	10	and	and	CC
cord-257027-q2y7fewk	187	11	the	the	DT
cord-257027-q2y7fewk	187	12	use	use	NN
cord-257027-q2y7fewk	187	13	and	and	CC
cord-257027-q2y7fewk	187	14	restraints	restraint	NNS
cord-257027-q2y7fewk	187	15	of	of	IN
cord-257027-q2y7fewk	187	16	relevant	relevant	JJ
cord-257027-q2y7fewk	187	17	animal	animal	NN
cord-257027-q2y7fewk	187	18	models	model	NNS
cord-257027-q2y7fewk	187	19	will	will	MD
cord-257027-q2y7fewk	187	20	be	be	VB
cord-257027-q2y7fewk	187	21	mandatory	mandatory	JJ
cord-257027-q2y7fewk	187	22	.	.	.
cord-257027-q2y7fewk	188	1	The	the	DT
cord-257027-q2y7fewk	188	2	human	human	JJ
cord-257027-q2y7fewk	188	3	genetic	genetic	JJ
cord-257027-q2y7fewk	188	4	variation	variation	NN
cord-257027-q2y7fewk	188	5	should	should	MD
cord-257027-q2y7fewk	188	6	also	also	RB
cord-257027-q2y7fewk	188	7	be	be	VB
cord-257027-q2y7fewk	188	8	taken	take	VBN
cord-257027-q2y7fewk	188	9	into	into	IN
cord-257027-q2y7fewk	188	10	account	account	NN
cord-257027-q2y7fewk	188	11	when	when	WRB
cord-257027-q2y7fewk	188	12	analyzing	analyze	VBG
cord-257027-q2y7fewk	188	13	the	the	DT
cord-257027-q2y7fewk	188	14	response	response	NN
cord-257027-q2y7fewk	188	15	to	to	IN
cord-257027-q2y7fewk	188	16	vaccination	vaccination	NN
cord-257027-q2y7fewk	188	17	.	.	.
cord-257027-q2y7fewk	189	1	Vaccine	vaccine	NN
cord-257027-q2y7fewk	189	2	strategies	strategy	NNS
cord-257027-q2y7fewk	189	3	may	may	MD
cord-257027-q2y7fewk	189	4	have	have	VB
cord-257027-q2y7fewk	189	5	to	to	TO
cord-257027-q2y7fewk	189	6	be	be	VB
cord-257027-q2y7fewk	189	7	adapted	adapt	VBN
cord-257027-q2y7fewk	189	8	to	to	TO
cord-257027-q2y7fewk	189	9	target	target	VB
cord-257027-q2y7fewk	189	10	groups	group	NNS
cord-257027-q2y7fewk	189	11	in	in	IN
cord-257027-q2y7fewk	189	12	order	order	NN
cord-257027-q2y7fewk	189	13	to	to	TO
cord-257027-q2y7fewk	189	14	optimize	optimize	VB
cord-257027-q2y7fewk	189	15	vaccination	vaccination	NN
cord-257027-q2y7fewk	189	16	efficacy	efficacy	NN
cord-257027-q2y7fewk	189	17	and	and	CC
cord-257027-q2y7fewk	189	18	reduce	reduce	VB
cord-257027-q2y7fewk	189	19	the	the	DT
cord-257027-q2y7fewk	189	20	risk	risk	NN
cord-257027-q2y7fewk	189	21	of	of	IN
cord-257027-q2y7fewk	189	22	adverse	adverse	JJ
cord-257027-q2y7fewk	189	23	events	event	NNS
cord-257027-q2y7fewk	189	24	.	.	.
cord-257027-q2y7fewk	190	1	Similarly	similarly	RB
cord-257027-q2y7fewk	190	2	,	,	,
cord-257027-q2y7fewk	190	3	the	the	DT
cord-257027-q2y7fewk	190	4	possibility	possibility	NN
cord-257027-q2y7fewk	190	5	of	of	IN
cord-257027-q2y7fewk	190	6	a	a	DT
cord-257027-q2y7fewk	190	7	personalized	personalized	JJ
cord-257027-q2y7fewk	190	8	vaccination	vaccination	NN
cord-257027-q2y7fewk	190	9	strategy	strategy	NN
cord-257027-q2y7fewk	190	10	(	(	-LRB-
cord-257027-q2y7fewk	190	11	appropriate	appropriate	JJ
cord-257027-q2y7fewk	190	12	dose	dose	NN
cord-257027-q2y7fewk	190	13	,	,	,
cord-257027-q2y7fewk	190	14	schedule	schedule	NN
cord-257027-q2y7fewk	190	15	and	and	CC
cord-257027-q2y7fewk	190	16	even	even	RB
cord-257027-q2y7fewk	190	17	molecular	molecular	JJ
cord-257027-q2y7fewk	190	18	components	component	NNS
cord-257027-q2y7fewk	190	19	of	of	IN
cord-257027-q2y7fewk	190	20	the	the	DT
cord-257027-q2y7fewk	190	21	vaccine	vaccine	NN
cord-257027-q2y7fewk	190	22	?	?	.
cord-257027-q2y7fewk	190	23	)	)	-RRB-
cord-257027-q2y7fewk	190	24	has	have	VBZ
cord-257027-q2y7fewk	190	25	been	be	VBN
cord-257027-q2y7fewk	190	26	suggested	suggest	VBN
cord-257027-q2y7fewk	190	27	,	,	,
cord-257027-q2y7fewk	190	28	which	which	WDT
cord-257027-q2y7fewk	190	29	would	would	MD
cord-257027-q2y7fewk	190	30	be	be	VB
cord-257027-q2y7fewk	190	31	based	base	VBN
cord-257027-q2y7fewk	190	32	on	on	IN
cord-257027-q2y7fewk	190	33	individual	individual	JJ
cord-257027-q2y7fewk	190	34	information	information	NN
cord-257027-q2y7fewk	190	35	,	,	,
cord-257027-q2y7fewk	190	36	including	include	VBG
cord-257027-q2y7fewk	190	37	genome	genome	NN
cord-257027-q2y7fewk	190	38	-	-	HYPH
cord-257027-q2y7fewk	190	39	wide	wide	JJ
cord-257027-q2y7fewk	190	40	genetic	genetic	JJ
cord-257027-q2y7fewk	190	41	information	information	NN
cord-257027-q2y7fewk	190	42	.	.	.
cord-257027-q2y7fewk	191	1	This	this	DT
cord-257027-q2y7fewk	191	2	implies	imply	VBZ
cord-257027-q2y7fewk	191	3	the	the	DT
cord-257027-q2y7fewk	191	4	ability	ability	NN
cord-257027-q2y7fewk	191	5	to	to	TO
cord-257027-q2y7fewk	191	6	predict	predict	VB
cord-257027-q2y7fewk	191	7	an	an	DT
cord-257027-q2y7fewk	191	8	individual	individual	JJ
cord-257027-q2y7fewk	191	9	response	response	NN
cord-257027-q2y7fewk	191	10	to	to	IN
cord-257027-q2y7fewk	191	11	the	the	DT
cord-257027-q2y7fewk	191	12	vaccine	vaccine	NN
cord-257027-q2y7fewk	191	13	.	.	.
cord-257027-q2y7fewk	192	1	The	the	DT
cord-257027-q2y7fewk	192	2	challenge	challenge	NN
cord-257027-q2y7fewk	192	3	is	be	VBZ
cord-257027-q2y7fewk	192	4	to	to	TO
cord-257027-q2y7fewk	192	5	develop	develop	VB
cord-257027-q2y7fewk	192	6	new	new	JJ
cord-257027-q2y7fewk	192	7	tools	tool	NNS
cord-257027-q2y7fewk	192	8	that	that	WDT
cord-257027-q2y7fewk	192	9	are	be	VBP
cord-257027-q2y7fewk	192	10	necessary	necessary	JJ
cord-257027-q2y7fewk	192	11	to	to	TO
cord-257027-q2y7fewk	192	12	accurately	accurately	RB
cord-257027-q2y7fewk	192	13	construct	construct	VB
cord-257027-q2y7fewk	192	14	and	and	CC
cord-257027-q2y7fewk	192	15	model	model	VB
cord-257027-q2y7fewk	192	16	molecular	molecular	JJ
cord-257027-q2y7fewk	192	17	networks	network	NNS
cord-257027-q2y7fewk	192	18	,	,	,
cord-257027-q2y7fewk	192	19	the	the	DT
cord-257027-q2y7fewk	192	20	perturbation	perturbation	NN
cord-257027-q2y7fewk	192	21	of	of	IN
cord-257027-q2y7fewk	192	22	which	which	WDT
cord-257027-q2y7fewk	192	23	causes	cause	VBZ
cord-257027-q2y7fewk	192	24	either	either	CC
cord-257027-q2y7fewk	192	25	the	the	DT
cord-257027-q2y7fewk	192	26	absence	absence	NN
cord-257027-q2y7fewk	192	27	of	of	IN
cord-257027-q2y7fewk	192	28	response	response	NN
cord-257027-q2y7fewk	192	29	or	or	CC
cord-257027-q2y7fewk	192	30	adverse	adverse	JJ
cord-257027-q2y7fewk	192	31	events	event	NNS
cord-257027-q2y7fewk	192	32	.	.	.
cord-257027-q2y7fewk	193	1	A	a	DT
cord-257027-q2y7fewk	193	2	2020	2020	CD
cord-257027-q2y7fewk	193	3	vision	vision	NN
cord-257027-q2y7fewk	193	4	for	for	IN
cord-257027-q2y7fewk	193	5	vaccines	vaccine	NNS
cord-257027-q2y7fewk	193	6	against	against	IN
cord-257027-q2y7fewk	193	7	HIV	HIV	NNP
cord-257027-q2y7fewk	193	8	,	,	,
cord-257027-q2y7fewk	193	9	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	193	10	and	and	CC
cord-257027-q2y7fewk	193	11	malaria	malaria	NN
cord-257027-q2y7fewk	194	1	The	the	DT
cord-257027-q2y7fewk	194	2	Genomes	Genomes	NNPS
cord-257027-q2y7fewk	194	3	On	on	IN
cord-257027-q2y7fewk	194	4	Line	line	NN
cord-257027-q2y7fewk	194	5	Database	database	NN
cord-257027-q2y7fewk	194	6	(	(	-LRB-
cord-257027-q2y7fewk	194	7	GOLD	gold	NN
cord-257027-q2y7fewk	194	8	)	)	-RRB-
cord-257027-q2y7fewk	194	9	in	in	IN
cord-257027-q2y7fewk	194	10	2009	2009	CD
cord-257027-q2y7fewk	194	11	:	:	:
cord-257027-q2y7fewk	194	12	status	status	NN
cord-257027-q2y7fewk	194	13	of	of	IN
cord-257027-q2y7fewk	194	14	genomic	genomic	JJ
cord-257027-q2y7fewk	194	15	and	and	CC
cord-257027-q2y7fewk	194	16	metagenomic	metagenomic	JJ
cord-257027-q2y7fewk	194	17	projects	project	NNS
cord-257027-q2y7fewk	194	18	and	and	CC
cord-257027-q2y7fewk	194	19	their	-PRON-	PRP$
cord-257027-q2y7fewk	194	20	associated	associate	VBN
cord-257027-q2y7fewk	194	21	metadata	metadata	NN
cord-257027-q2y7fewk	194	22	Genome	Genome	NNP
cord-257027-q2y7fewk	194	23	-	-	HYPH
cord-257027-q2y7fewk	194	24	based	base	VBN
cord-257027-q2y7fewk	194	25	vaccines	vaccine	NNS
cord-257027-q2y7fewk	195	1	The	the	DT
cord-257027-q2y7fewk	195	2	top	top	JJ
cord-257027-q2y7fewk	195	3	five	five	CD
cord-257027-q2y7fewk	195	4	"	"	``
cord-257027-q2y7fewk	195	5	game	game	NN
cord-257027-q2y7fewk	195	6	changers	changer	NNS
cord-257027-q2y7fewk	195	7	"	"	''
cord-257027-q2y7fewk	195	8	in	in	IN
cord-257027-q2y7fewk	195	9	vaccinology	vaccinology	NN
cord-257027-q2y7fewk	195	10	:	:	:
cord-257027-q2y7fewk	195	11	toward	toward	IN
cord-257027-q2y7fewk	195	12	rational	rational	JJ
cord-257027-q2y7fewk	195	13	and	and	CC
cord-257027-q2y7fewk	195	14	directed	direct	VBD
cord-257027-q2y7fewk	195	15	vaccine	vaccine	NN
cord-257027-q2y7fewk	195	16	development	development	NN
cord-257027-q2y7fewk	195	17	Whole	Whole	NNP
cord-257027-q2y7fewk	195	18	-	-	HYPH
cord-257027-q2y7fewk	195	19	genome	genome	NN
cord-257027-q2y7fewk	195	20	random	random	JJ
cord-257027-q2y7fewk	195	21	sequencing	sequencing	NN
cord-257027-q2y7fewk	195	22	and	and	CC
cord-257027-q2y7fewk	195	23	assembly	assembly	NN
cord-257027-q2y7fewk	195	24	of	of	IN
cord-257027-q2y7fewk	195	25	Haemophilus	Haemophilus	NNP
cord-257027-q2y7fewk	195	26	influenzae	influenzae	NN
cord-257027-q2y7fewk	196	1	Rd	Rd	NNP
cord-257027-q2y7fewk	196	2	Reverse	Reverse	NNP
cord-257027-q2y7fewk	196	3	vaccinology	vaccinology	NN
cord-257027-q2y7fewk	196	4	and	and	CC
cord-257027-q2y7fewk	196	5	genomics	genomic	NNS
cord-257027-q2y7fewk	196	6	Comparative	comparative	JJ
cord-257027-q2y7fewk	196	7	analysis	analysis	NN
cord-257027-q2y7fewk	196	8	of	of	IN
cord-257027-q2y7fewk	196	9	epitope	epitope	NN
cord-257027-q2y7fewk	196	10	predictions	prediction	NNS
cord-257027-q2y7fewk	196	11	:	:	:
cord-257027-q2y7fewk	196	12	proposed	propose	VBN
cord-257027-q2y7fewk	196	13	library	library	NN
cord-257027-q2y7fewk	196	14	of	of	IN
cord-257027-q2y7fewk	196	15	putative	putative	JJ
cord-257027-q2y7fewk	196	16	vaccine	vaccine	NN
cord-257027-q2y7fewk	196	17	candidates	candidate	NNS
cord-257027-q2y7fewk	196	18	for	for	IN
cord-257027-q2y7fewk	196	19	HIV	HIV	NNP
cord-257027-q2y7fewk	196	20	Identification	Identification	NNP
cord-257027-q2y7fewk	196	21	of	of	IN
cord-257027-q2y7fewk	196	22	vaccine	vaccine	NN
cord-257027-q2y7fewk	196	23	candidates	candidate	NNS
cord-257027-q2y7fewk	196	24	against	against	IN
cord-257027-q2y7fewk	196	25	serogroup	serogroup	NNP
cord-257027-q2y7fewk	196	26	B	B	NNP
cord-257027-q2y7fewk	196	27	meningococcus	meningococcus	NN
cord-257027-q2y7fewk	196	28	by	by	IN
cord-257027-q2y7fewk	196	29	whole	whole	JJ
cord-257027-q2y7fewk	196	30	-	-	HYPH
cord-257027-q2y7fewk	196	31	genome	genome	NN
cord-257027-q2y7fewk	196	32	sequencing	sequencing	NN
cord-257027-q2y7fewk	196	33	Epidemiological	epidemiological	JJ
cord-257027-q2y7fewk	196	34	profile	profile	NN
cord-257027-q2y7fewk	196	35	of	of	IN
cord-257027-q2y7fewk	196	36	meningococcal	meningococcal	JJ
cord-257027-q2y7fewk	196	37	disease	disease	NN
cord-257027-q2y7fewk	196	38	in	in	IN
cord-257027-q2y7fewk	196	39	the	the	DT
cord-257027-q2y7fewk	196	40	United	United	NNP
cord-257027-q2y7fewk	196	41	States	States	NNP
cord-257027-q2y7fewk	197	1	A	a	DT
cord-257027-q2y7fewk	197	2	universal	universal	JJ
cord-257027-q2y7fewk	197	3	vaccine	vaccine	NN
cord-257027-q2y7fewk	197	4	for	for	IN
cord-257027-q2y7fewk	197	5	serogroup	serogroup	NNP
cord-257027-q2y7fewk	197	6	B	B	NNP
cord-257027-q2y7fewk	197	7	meningococcus	meningococcus	NNP
cord-257027-q2y7fewk	197	8	Immunogenicity	Immunogenicity	NNP
cord-257027-q2y7fewk	197	9	and	and	CC
cord-257027-q2y7fewk	197	10	safety	safety	NN
cord-257027-q2y7fewk	197	11	of	of	IN
cord-257027-q2y7fewk	197	12	a	a	DT
cord-257027-q2y7fewk	197	13	multicomponent	multicomponent	JJ
cord-257027-q2y7fewk	197	14	meningococcal	meningococcal	JJ
cord-257027-q2y7fewk	197	15	serogroup	serogroup	NN
cord-257027-q2y7fewk	197	16	B	B	NNP
cord-257027-q2y7fewk	197	17	vaccine	vaccine	NN
cord-257027-q2y7fewk	197	18	and	and	CC
cord-257027-q2y7fewk	197	19	a	a	DT
cord-257027-q2y7fewk	197	20	quadrivalent	quadrivalent	NN
cord-257027-q2y7fewk	197	21	meningococcal	meningococcal	JJ
cord-257027-q2y7fewk	197	22	CRM197	crm197	NN
cord-257027-q2y7fewk	197	23	conjugate	conjugate	NN
cord-257027-q2y7fewk	197	24	vaccine	vaccine	NN
cord-257027-q2y7fewk	197	25	against	against	IN
cord-257027-q2y7fewk	197	26	serogroups	serogroups	NNP
cord-257027-q2y7fewk	197	27	A	A	NNP
cord-257027-q2y7fewk	197	28	,	,	,
cord-257027-q2y7fewk	197	29	C	C	NNP
cord-257027-q2y7fewk	197	30	,	,	,
cord-257027-q2y7fewk	197	31	W-135	w-135	XX
cord-257027-q2y7fewk	197	32	,	,	,
cord-257027-q2y7fewk	197	33	and	and	CC
cord-257027-q2y7fewk	197	34	Y	Y	NNP
cord-257027-q2y7fewk	197	35	in	in	IN
cord-257027-q2y7fewk	197	36	adults	adult	NNS
cord-257027-q2y7fewk	197	37	who	who	WP
cord-257027-q2y7fewk	197	38	are	be	VBP
cord-257027-q2y7fewk	197	39	at	at	IN
cord-257027-q2y7fewk	197	40	increased	increase	VBN
cord-257027-q2y7fewk	197	41	risk	risk	NN
cord-257027-q2y7fewk	197	42	for	for	IN
cord-257027-q2y7fewk	197	43	occupational	occupational	JJ
cord-257027-q2y7fewk	197	44	exposure	exposure	NN
cord-257027-q2y7fewk	197	45	to	to	IN
cord-257027-q2y7fewk	197	46	meningococcal	meningococcal	JJ
cord-257027-q2y7fewk	197	47	isolates	isolate	NNS
cord-257027-q2y7fewk	197	48	Vaccinology	Vaccinology	NNP
cord-257027-q2y7fewk	197	49	in	in	IN
cord-257027-q2y7fewk	197	50	the	the	DT
cord-257027-q2y7fewk	197	51	genome	genome	NN
cord-257027-q2y7fewk	197	52	era	era	NN
cord-257027-q2y7fewk	198	1	HLA	HLA	NNP
cord-257027-q2y7fewk	198	2	supertype-	supertype-	NNP
cord-257027-q2y7fewk	199	1	,	,	,
cord-257027-q2y7fewk	199	2	genome	genome	NN
cord-257027-q2y7fewk	199	3	-	-	HYPH
cord-257027-q2y7fewk	199	4	wide	wide	JJ
cord-257027-q2y7fewk	199	5	scanning	scanning	NN
cord-257027-q2y7fewk	199	6	and	and	CC
cord-257027-q2y7fewk	199	7	biochemical	biochemical	JJ
cord-257027-q2y7fewk	199	8	validation	validation	NN
cord-257027-q2y7fewk	199	9	Polyvalent	Polyvalent	NNP
cord-257027-q2y7fewk	199	10	vaccines	vaccine	NNS
cord-257027-q2y7fewk	199	11	for	for	IN
cord-257027-q2y7fewk	199	12	optimal	optimal	JJ
cord-257027-q2y7fewk	199	13	coverage	coverage	NN
cord-257027-q2y7fewk	199	14	of	of	IN
cord-257027-q2y7fewk	199	15	potential	potential	JJ
cord-257027-q2y7fewk	199	16	T	t	NN
cord-257027-q2y7fewk	199	17	-	-	HYPH
cord-257027-q2y7fewk	199	18	cell	cell	NN
cord-257027-q2y7fewk	199	19	epitopes	epitope	NNS
cord-257027-q2y7fewk	199	20	in	in	IN
cord-257027-q2y7fewk	199	21	global	global	JJ
cord-257027-q2y7fewk	199	22	HIV-1	HIV-1	NNP
cord-257027-q2y7fewk	199	23	variants	variant	NNS
cord-257027-q2y7fewk	199	24	Utility	Utility	NNP
cord-257027-q2y7fewk	199	25	of	of	IN
cord-257027-q2y7fewk	199	26	the	the	DT
cord-257027-q2y7fewk	199	27	Trypanosoma	Trypanosoma	NNP
cord-257027-q2y7fewk	199	28	cruzi	cruzi	NN
cord-257027-q2y7fewk	199	29	sequence	sequence	NN
cord-257027-q2y7fewk	199	30	database	database	NN
cord-257027-q2y7fewk	199	31	for	for	IN
cord-257027-q2y7fewk	199	32	identification	identification	NN
cord-257027-q2y7fewk	199	33	of	of	IN
cord-257027-q2y7fewk	199	34	potential	potential	JJ
cord-257027-q2y7fewk	199	35	vaccine	vaccine	NN
cord-257027-q2y7fewk	199	36	candidates	candidate	NNS
cord-257027-q2y7fewk	199	37	by	by	IN
cord-257027-q2y7fewk	199	38	in	in	IN
cord-257027-q2y7fewk	199	39	silico	silico	NNS
cord-257027-q2y7fewk	199	40	and	and	CC
cord-257027-q2y7fewk	199	41	in	in	IN
cord-257027-q2y7fewk	199	42	vitro	vitro	FW
cord-257027-q2y7fewk	199	43	screening	screen	VBG
cord-257027-q2y7fewk	199	44	Genome	genome	NN
cord-257027-q2y7fewk	199	45	-	-	HYPH
cord-257027-q2y7fewk	199	46	wide	wide	JJ
cord-257027-q2y7fewk	199	47	variation	variation	NN
cord-257027-q2y7fewk	199	48	and	and	CC
cord-257027-q2y7fewk	199	49	identification	identification	NN
cord-257027-q2y7fewk	199	50	of	of	IN
cord-257027-q2y7fewk	199	51	vaccine	vaccine	NN
cord-257027-q2y7fewk	199	52	targets	target	NNS
cord-257027-q2y7fewk	199	53	in	in	IN
cord-257027-q2y7fewk	199	54	the	the	DT
cord-257027-q2y7fewk	199	55	Plasmodium	Plasmodium	NNP
cord-257027-q2y7fewk	199	56	falciparum	falciparum	NN
cord-257027-q2y7fewk	199	57	genome	genome	NN
cord-257027-q2y7fewk	199	58	Vaccine	vaccine	NN
cord-257027-q2y7fewk	199	59	-	-	HYPH
cord-257027-q2y7fewk	199	60	induced	induce	VBN
cord-257027-q2y7fewk	199	61	immunity	immunity	NN
cord-257027-q2y7fewk	199	62	circumvented	circumvent	VBN
cord-257027-q2y7fewk	199	63	by	by	IN
cord-257027-q2y7fewk	199	64	typical	typical	JJ
cord-257027-q2y7fewk	199	65	Mycobacterium	Mycobacterium	NNP
cord-257027-q2y7fewk	199	66	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	199	67	Beijing	Beijing	NNP
cord-257027-q2y7fewk	199	68	strains	strain	VBZ
cord-257027-q2y7fewk	199	69	Variation	variation	NN
cord-257027-q2y7fewk	199	70	in	in	IN
cord-257027-q2y7fewk	199	71	protection	protection	NN
cord-257027-q2y7fewk	199	72	by	by	IN
cord-257027-q2y7fewk	199	73	BCG	BCG	NNP
cord-257027-q2y7fewk	199	74	:	:	:
cord-257027-q2y7fewk	199	75	implications	implication	NNS
cord-257027-q2y7fewk	199	76	of	of	IN
cord-257027-q2y7fewk	199	77	and	and	CC
cord-257027-q2y7fewk	199	78	for	for	IN
cord-257027-q2y7fewk	199	79	heterologous	heterologous	JJ
cord-257027-q2y7fewk	199	80	immunity	immunity	NN
cord-257027-q2y7fewk	199	81	Identification	Identification	NNP
cord-257027-q2y7fewk	199	82	of	of	IN
cord-257027-q2y7fewk	199	83	a	a	DT
cord-257027-q2y7fewk	199	84	universal	universal	JJ
cord-257027-q2y7fewk	199	85	Group	Group	NNP
cord-257027-q2y7fewk	199	86	B	B	NNP
cord-257027-q2y7fewk	199	87	streptococcus	streptococcus	NN
cord-257027-q2y7fewk	199	88	vaccine	vaccine	NN
cord-257027-q2y7fewk	199	89	by	by	IN
cord-257027-q2y7fewk	199	90	multiple	multiple	JJ
cord-257027-q2y7fewk	199	91	genome	genome	NN
cord-257027-q2y7fewk	199	92	screen	screen	NN
cord-257027-q2y7fewk	200	1	The	the	DT
cord-257027-q2y7fewk	200	2	use	use	NN
cord-257027-q2y7fewk	200	3	of	of	IN
cord-257027-q2y7fewk	200	4	genomics	genomic	NNS
cord-257027-q2y7fewk	200	5	in	in	IN
cord-257027-q2y7fewk	200	6	microbial	microbial	JJ
cord-257027-q2y7fewk	200	7	vaccine	vaccine	NN
cord-257027-q2y7fewk	200	8	development	development	NN
cord-257027-q2y7fewk	200	9	Evidence	Evidence	NNP
cord-257027-q2y7fewk	200	10	that	that	IN
cord-257027-q2y7fewk	200	11	pneumococcal	pneumococcal	JJ
cord-257027-q2y7fewk	200	12	serotype	serotype	NN
cord-257027-q2y7fewk	200	13	replacement	replacement	NN
cord-257027-q2y7fewk	200	14	in	in	IN
cord-257027-q2y7fewk	200	15	Massachusetts	Massachusetts	NNP
cord-257027-q2y7fewk	200	16	following	follow	VBG
cord-257027-q2y7fewk	200	17	conjugate	conjugate	JJ
cord-257027-q2y7fewk	200	18	vaccination	vaccination	NN
cord-257027-q2y7fewk	200	19	is	be	VBZ
cord-257027-q2y7fewk	200	20	now	now	RB
cord-257027-q2y7fewk	200	21	complete	complete	JJ
cord-257027-q2y7fewk	200	22	Human	human	JJ
cord-257027-q2y7fewk	200	23	genetics	genetic	NNS
cord-257027-q2y7fewk	200	24	of	of	IN
cord-257027-q2y7fewk	200	25	infectious	infectious	JJ
cord-257027-q2y7fewk	200	26	diseases	disease	NNS
cord-257027-q2y7fewk	200	27	:	:	:
cord-257027-q2y7fewk	200	28	a	a	DT
cord-257027-q2y7fewk	200	29	unified	unified	JJ
cord-257027-q2y7fewk	200	30	theory	theory	NN
cord-257027-q2y7fewk	200	31	Genome	Genome	NNP
cord-257027-q2y7fewk	200	32	-	-	HYPH
cord-257027-q2y7fewk	200	33	wide	wide	JJ
cord-257027-q2y7fewk	200	34	association	association	NN
cord-257027-q2y7fewk	200	35	studies	study	NNS
cord-257027-q2y7fewk	200	36	and	and	CC
cord-257027-q2y7fewk	200	37	infectious	infectious	JJ
cord-257027-q2y7fewk	200	38	disease	disease	NN
cord-257027-q2y7fewk	200	39	Functional	functional	JJ
cord-257027-q2y7fewk	200	40	gene	gene	NN
cord-257027-q2y7fewk	200	41	discovery	discovery	NN
cord-257027-q2y7fewk	200	42	using	use	VBG
cord-257027-q2y7fewk	200	43	RNA	RNA	NNP
cord-257027-q2y7fewk	200	44	interference	interference	NN
cord-257027-q2y7fewk	200	45	-	-	HYPH
cord-257027-q2y7fewk	200	46	based	base	VBN
cord-257027-q2y7fewk	200	47	genomic	genomic	JJ
cord-257027-q2y7fewk	200	48	screens	screen	NNS
cord-257027-q2y7fewk	200	49	to	to	TO
cord-257027-q2y7fewk	200	50	combat	combat	VB
cord-257027-q2y7fewk	200	51	pathogen	pathogen	NN
cord-257027-q2y7fewk	200	52	infection	infection	NN
cord-257027-q2y7fewk	200	53	Genetic	genetic	JJ
cord-257027-q2y7fewk	200	54	localization	localization	NN
cord-257027-q2y7fewk	200	55	of	of	IN
cord-257027-q2y7fewk	200	56	a	a	DT
cord-257027-q2y7fewk	200	57	locus	locus	NN
cord-257027-q2y7fewk	200	58	controlling	control	VBG
cord-257027-q2y7fewk	200	59	the	the	DT
cord-257027-q2y7fewk	200	60	intensity	intensity	NN
cord-257027-q2y7fewk	200	61	of	of	IN
cord-257027-q2y7fewk	200	62	infection	infection	NN
cord-257027-q2y7fewk	200	63	by	by	IN
cord-257027-q2y7fewk	200	64	Schistosoma	Schistosoma	NNP
cord-257027-q2y7fewk	200	65	mansoni	mansoni	NN
cord-257027-q2y7fewk	200	66	on	on	IN
cord-257027-q2y7fewk	200	67	chromosome	chromosome	NN
cord-257027-q2y7fewk	200	68	5q31-q33	5q31-q33	CD
cord-257027-q2y7fewk	200	69	Severe	severe	JJ
cord-257027-q2y7fewk	200	70	hepatic	hepatic	JJ
cord-257027-q2y7fewk	200	71	fibrosis	fibrosis	NN
cord-257027-q2y7fewk	200	72	in	in	IN
cord-257027-q2y7fewk	200	73	Schistosoma	Schistosoma	NNP
cord-257027-q2y7fewk	200	74	mansoni	mansoni	JJ
cord-257027-q2y7fewk	200	75	infection	infection	NN
cord-257027-q2y7fewk	200	76	is	be	VBZ
cord-257027-q2y7fewk	200	77	controlled	control	VBN
cord-257027-q2y7fewk	200	78	by	by	IN
cord-257027-q2y7fewk	200	79	a	a	DT
cord-257027-q2y7fewk	200	80	major	major	JJ
cord-257027-q2y7fewk	200	81	locus	locus	NN
cord-257027-q2y7fewk	200	82	that	that	WDT
cord-257027-q2y7fewk	200	83	is	be	VBZ
cord-257027-q2y7fewk	200	84	closely	closely	RB
cord-257027-q2y7fewk	200	85	linked	link	VBN
cord-257027-q2y7fewk	200	86	to	to	IN
cord-257027-q2y7fewk	200	87	the	the	DT
cord-257027-q2y7fewk	200	88	interferon	interferon	NN
cord-257027-q2y7fewk	200	89	-	-	HYPH
cord-257027-q2y7fewk	200	90	gamma	gamma	NN
cord-257027-q2y7fewk	200	91	receptor	receptor	NN
cord-257027-q2y7fewk	200	92	gene	gene	NN
cord-257027-q2y7fewk	201	1	An	an	DT
cord-257027-q2y7fewk	201	2	autosomal	autosomal	JJ
cord-257027-q2y7fewk	201	3	dominant	dominant	JJ
cord-257027-q2y7fewk	201	4	major	major	JJ
cord-257027-q2y7fewk	201	5	gene	gene	NN
cord-257027-q2y7fewk	201	6	confers	confer	VBZ
cord-257027-q2y7fewk	201	7	predisposition	predisposition	NN
cord-257027-q2y7fewk	201	8	to	to	IN
cord-257027-q2y7fewk	201	9	pulmonary	pulmonary	JJ
cord-257027-q2y7fewk	201	10	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	201	11	in	in	IN
cord-257027-q2y7fewk	201	12	adults	adult	NNS
cord-257027-q2y7fewk	201	13	Genetic	genetic	JJ
cord-257027-q2y7fewk	201	14	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	201	15	to	to	IN
cord-257027-q2y7fewk	201	16	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	201	17	in	in	IN
cord-257027-q2y7fewk	201	18	Africans	Africans	NNPS
cord-257027-q2y7fewk	201	19	:	:	:
cord-257027-q2y7fewk	201	20	a	a	DT
cord-257027-q2y7fewk	201	21	genome	genome	NN
cord-257027-q2y7fewk	201	22	-	-	HYPH
cord-257027-q2y7fewk	201	23	wide	wide	JJ
cord-257027-q2y7fewk	201	24	scan	scan	NN
cord-257027-q2y7fewk	202	1	A	a	DT
cord-257027-q2y7fewk	202	2	major	major	JJ
cord-257027-q2y7fewk	202	3	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	202	4	locus	locus	NN
cord-257027-q2y7fewk	202	5	for	for	IN
cord-257027-q2y7fewk	202	6	leprosy	leprosy	NN
cord-257027-q2y7fewk	202	7	in	in	IN
cord-257027-q2y7fewk	202	8	India	India	NNP
cord-257027-q2y7fewk	202	9	maps	map	NNS
cord-257027-q2y7fewk	202	10	to	to	TO
cord-257027-q2y7fewk	202	11	chromosome	chromosome	VB
cord-257027-q2y7fewk	202	12	10p13	10p13	CD
cord-257027-q2y7fewk	203	1	Chromosome	chromosome	NN
cord-257027-q2y7fewk	203	2	6q25	6q25	CD
cord-257027-q2y7fewk	203	3	is	be	VBZ
cord-257027-q2y7fewk	203	4	linked	link	VBN
cord-257027-q2y7fewk	203	5	to	to	IN
cord-257027-q2y7fewk	203	6	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	203	7	to	to	IN
cord-257027-q2y7fewk	203	8	leprosy	leprosy	NN
cord-257027-q2y7fewk	203	9	in	in	IN
cord-257027-q2y7fewk	203	10	a	a	DT
cord-257027-q2y7fewk	203	11	Vietnamese	vietnamese	JJ
cord-257027-q2y7fewk	203	12	population	population	NN
cord-257027-q2y7fewk	204	1	A	a	DT
cord-257027-q2y7fewk	204	2	major	major	JJ
cord-257027-q2y7fewk	204	3	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	204	4	locus	locus	NN
cord-257027-q2y7fewk	204	5	on	on	IN
cord-257027-q2y7fewk	204	6	chromosome	chromosome	NN
cord-257027-q2y7fewk	204	7	22q12	22q12	CD
cord-257027-q2y7fewk	204	8	plays	play	VBZ
cord-257027-q2y7fewk	204	9	a	a	DT
cord-257027-q2y7fewk	204	10	critical	critical	JJ
cord-257027-q2y7fewk	204	11	role	role	NN
cord-257027-q2y7fewk	204	12	in	in	IN
cord-257027-q2y7fewk	204	13	the	the	DT
cord-257027-q2y7fewk	204	14	control	control	NN
cord-257027-q2y7fewk	204	15	of	of	IN
cord-257027-q2y7fewk	204	16	kala	kala	NNP
cord-257027-q2y7fewk	204	17	-	-	HYPH
cord-257027-q2y7fewk	204	18	azar	azar	NNP
cord-257027-q2y7fewk	204	19	Innate	innate	JJ
cord-257027-q2y7fewk	204	20	immunity	immunity	NN
cord-257027-q2y7fewk	204	21	genes	gene	NNS
cord-257027-q2y7fewk	204	22	as	as	IN
cord-257027-q2y7fewk	204	23	candidate	candidate	NN
cord-257027-q2y7fewk	204	24	genes	gene	NNS
cord-257027-q2y7fewk	204	25	:	:	:
cord-257027-q2y7fewk	204	26	searching	search	VBG
cord-257027-q2y7fewk	204	27	for	for	IN
cord-257027-q2y7fewk	204	28	relevant	relevant	JJ
cord-257027-q2y7fewk	204	29	natural	natural	JJ
cord-257027-q2y7fewk	204	30	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	204	31	in	in	IN
cord-257027-q2y7fewk	204	32	databases	database	NNS
cord-257027-q2y7fewk	204	33	and	and	CC
cord-257027-q2y7fewk	204	34	assessing	assess	VBG
cord-257027-q2y7fewk	204	35	family	family	NN
cord-257027-q2y7fewk	204	36	-	-	HYPH
cord-257027-q2y7fewk	204	37	based	base	VBN
cord-257027-q2y7fewk	204	38	association	association	NN
cord-257027-q2y7fewk	204	39	of	of	IN
cord-257027-q2y7fewk	204	40	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	204	41	with	with	IN
cord-257027-q2y7fewk	204	42	human	human	JJ
cord-257027-q2y7fewk	204	43	diseases	disease	NNS
cord-257027-q2y7fewk	204	44	Genetic	genetic	JJ
cord-257027-q2y7fewk	204	45	determination	determination	NN
cord-257027-q2y7fewk	204	46	and	and	CC
cord-257027-q2y7fewk	204	47	linkage	linkage	NN
cord-257027-q2y7fewk	204	48	mapping	mapping	NN
cord-257027-q2y7fewk	204	49	of	of	IN
cord-257027-q2y7fewk	204	50	Plasmodium	Plasmodium	NNP
cord-257027-q2y7fewk	204	51	falciparum	falciparum	NN
cord-257027-q2y7fewk	204	52	malaria	malaria	NN
cord-257027-q2y7fewk	204	53	related	relate	VBN
cord-257027-q2y7fewk	204	54	traits	trait	NNS
cord-257027-q2y7fewk	204	55	in	in	IN
cord-257027-q2y7fewk	204	56	Senegal	Senegal	NNP
cord-257027-q2y7fewk	204	57	Linkage	Linkage	NNP
cord-257027-q2y7fewk	204	58	of	of	IN
cord-257027-q2y7fewk	204	59	mild	mild	JJ
cord-257027-q2y7fewk	204	60	malaria	malaria	NN
cord-257027-q2y7fewk	204	61	to	to	IN
cord-257027-q2y7fewk	204	62	the	the	DT
cord-257027-q2y7fewk	204	63	major	major	JJ
cord-257027-q2y7fewk	204	64	histocompatibility	histocompatibility	NN
cord-257027-q2y7fewk	204	65	complex	complex	NN
cord-257027-q2y7fewk	204	66	in	in	IN
cord-257027-q2y7fewk	204	67	families	family	NNS
cord-257027-q2y7fewk	204	68	living	live	VBG
cord-257027-q2y7fewk	204	69	in	in	IN
cord-257027-q2y7fewk	204	70	Burkina	Burkina	NNP
cord-257027-q2y7fewk	204	71	Faso	Faso	NNP
cord-257027-q2y7fewk	204	72	Genome	Genome	NNP
cord-257027-q2y7fewk	204	73	-	-	HYPH
cord-257027-q2y7fewk	204	74	wide	wide	JJ
cord-257027-q2y7fewk	204	75	and	and	CC
cord-257027-q2y7fewk	204	76	fine	fine	JJ
cord-257027-q2y7fewk	204	77	-	-	HYPH
cord-257027-q2y7fewk	204	78	resolution	resolution	NN
cord-257027-q2y7fewk	204	79	association	association	NN
cord-257027-q2y7fewk	204	80	analysis	analysis	NN
cord-257027-q2y7fewk	204	81	of	of	IN
cord-257027-q2y7fewk	204	82	malaria	malaria	NNP
cord-257027-q2y7fewk	204	83	in	in	IN
cord-257027-q2y7fewk	204	84	West	West	NNP
cord-257027-q2y7fewk	204	85	Africa	Africa	NNP
cord-257027-q2y7fewk	204	86	Analysis	Analysis	NNP
cord-257027-q2y7fewk	204	87	of	of	IN
cord-257027-q2y7fewk	204	88	the	the	DT
cord-257027-q2y7fewk	204	89	5q31-q33	5q31-q33	CD
cord-257027-q2y7fewk	204	90	locus	locus	NN
cord-257027-q2y7fewk	205	1	shows	show	VBZ
cord-257027-q2y7fewk	205	2	an	an	DT
cord-257027-q2y7fewk	205	3	association	association	NN
cord-257027-q2y7fewk	205	4	between	between	IN
cord-257027-q2y7fewk	205	5	IL13	IL13	NNP
cord-257027-q2y7fewk	205	6	-	-	HYPH
cord-257027-q2y7fewk	205	7	1055C	1055C	NNP
cord-257027-q2y7fewk	205	8	/	/	SYM
cord-257027-q2y7fewk	205	9	T	T	NNP
cord-257027-q2y7fewk	205	10	IL-13	IL-13	NNP
cord-257027-q2y7fewk	205	11	-	-	HYPH
cord-257027-q2y7fewk	205	12	591A	591A	NNP
cord-257027-q2y7fewk	205	13	/	/	SYM
cord-257027-q2y7fewk	205	14	G	g	NN
cord-257027-q2y7fewk	205	15	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	205	16	and	and	CC
cord-257027-q2y7fewk	205	17	Schistosoma	Schistosoma	NNP
cord-257027-q2y7fewk	205	18	haematobium	haematobium	NN
cord-257027-q2y7fewk	205	19	infections	infection	NNS
cord-257027-q2y7fewk	205	20	TNF	TNF	NNP
cord-257027-q2y7fewk	205	21	as	as	IN
cord-257027-q2y7fewk	205	22	a	a	DT
cord-257027-q2y7fewk	205	23	malaria	malaria	NN
cord-257027-q2y7fewk	205	24	candidate	candidate	NN
cord-257027-q2y7fewk	205	25	gene	gene	NN
cord-257027-q2y7fewk	205	26	:	:	:
cord-257027-q2y7fewk	205	27	polymorphism	polymorphism	NN
cord-257027-q2y7fewk	205	28	-	-	HYPH
cord-257027-q2y7fewk	205	29	screening	screening	NN
cord-257027-q2y7fewk	205	30	and	and	CC
cord-257027-q2y7fewk	205	31	family	family	NN
cord-257027-q2y7fewk	205	32	-	-	HYPH
cord-257027-q2y7fewk	205	33	based	base	VBN
cord-257027-q2y7fewk	205	34	association	association	NN
cord-257027-q2y7fewk	205	35	analysis	analysis	NN
cord-257027-q2y7fewk	205	36	of	of	IN
cord-257027-q2y7fewk	205	37	mild	mild	JJ
cord-257027-q2y7fewk	205	38	malaria	malaria	NN
cord-257027-q2y7fewk	205	39	attack	attack	NN
cord-257027-q2y7fewk	205	40	and	and	CC
cord-257027-q2y7fewk	205	41	parasitemia	parasitemia	NN
cord-257027-q2y7fewk	205	42	in	in	IN
cord-257027-q2y7fewk	205	43	Burkina	Burkina	NNP
cord-257027-q2y7fewk	205	44	Faso	Faso	NNP
cord-257027-q2y7fewk	205	45	Association	Association	NNP
cord-257027-q2y7fewk	205	46	analyses	analysis	NNS
cord-257027-q2y7fewk	205	47	of	of	IN
cord-257027-q2y7fewk	205	48	NCR3	NCR3	NNP
cord-257027-q2y7fewk	205	49	polymorphisms	polymorphism	NNS
cord-257027-q2y7fewk	205	50	with	with	IN
cord-257027-q2y7fewk	205	51	P.	p.	NN
cord-257027-q2y7fewk	205	52	falciparum	falciparum	NN
cord-257027-q2y7fewk	206	1	mild	mild	JJ
cord-257027-q2y7fewk	206	2	malaria	malaria	NN
cord-257027-q2y7fewk	206	3	Susceptibility	susceptibility	NN
cord-257027-q2y7fewk	206	4	to	to	IN
cord-257027-q2y7fewk	206	5	leprosy	leprosy	NN
cord-257027-q2y7fewk	206	6	is	be	VBZ
cord-257027-q2y7fewk	206	7	associated	associate	VBN
cord-257027-q2y7fewk	206	8	with	with	IN
cord-257027-q2y7fewk	206	9	PARK2	PARK2	NNS
cord-257027-q2y7fewk	206	10	and	and	CC
cord-257027-q2y7fewk	206	11	PACRG	PACRG	NNP
cord-257027-q2y7fewk	207	1	A	a	DT
cord-257027-q2y7fewk	207	2	whole	whole	JJ
cord-257027-q2y7fewk	207	3	-	-	HYPH
cord-257027-q2y7fewk	207	4	genome	genome	NN
cord-257027-q2y7fewk	207	5	association	association	NN
cord-257027-q2y7fewk	207	6	study	study	NN
cord-257027-q2y7fewk	207	7	of	of	IN
cord-257027-q2y7fewk	207	8	major	major	JJ
cord-257027-q2y7fewk	207	9	determinants	determinant	NNS
cord-257027-q2y7fewk	207	10	for	for	IN
cord-257027-q2y7fewk	207	11	host	host	NN
cord-257027-q2y7fewk	207	12	control	control	NN
cord-257027-q2y7fewk	207	13	of	of	IN
cord-257027-q2y7fewk	207	14	HIV-1	HIV-1	NNP
cord-257027-q2y7fewk	207	15	A	A	NNP
cord-257027-q2y7fewk	207	16	genome	genome	NN
cord-257027-q2y7fewk	207	17	-	-	HYPH
cord-257027-q2y7fewk	207	18	wide	wide	JJ
cord-257027-q2y7fewk	207	19	association	association	NN
cord-257027-q2y7fewk	207	20	study	study	NN
cord-257027-q2y7fewk	207	21	identifies	identify	VBZ
cord-257027-q2y7fewk	207	22	variants	variant	NNS
cord-257027-q2y7fewk	207	23	in	in	IN
cord-257027-q2y7fewk	207	24	the	the	DT
cord-257027-q2y7fewk	207	25	HLA	HLA	NNP
cord-257027-q2y7fewk	207	26	-	-	HYPH
cord-257027-q2y7fewk	207	27	DP	dp	NN
cord-257027-q2y7fewk	207	28	locus	locus	NN
cord-257027-q2y7fewk	207	29	associated	associate	VBN
cord-257027-q2y7fewk	207	30	with	with	IN
cord-257027-q2y7fewk	207	31	chronic	chronic	JJ
cord-257027-q2y7fewk	207	32	hepatitis	hepatitis	NN
cord-257027-q2y7fewk	207	33	B	b	NN
cord-257027-q2y7fewk	207	34	in	in	IN
cord-257027-q2y7fewk	207	35	Asians	Asians	NNP
cord-257027-q2y7fewk	207	36	Genome	Genome	NNP
cord-257027-q2y7fewk	207	37	-	-	HYPH
cord-257027-q2y7fewk	207	38	wide	wide	JJ
cord-257027-q2y7fewk	207	39	association	association	NN
cord-257027-q2y7fewk	207	40	of	of	IN
cord-257027-q2y7fewk	207	41	IL28B	IL28B	NNP
cord-257027-q2y7fewk	208	1	with	with	IN
cord-257027-q2y7fewk	208	2	response	response	NN
cord-257027-q2y7fewk	208	3	to	to	IN
cord-257027-q2y7fewk	208	4	pegylated	pegylated	JJ
cord-257027-q2y7fewk	208	5	interferon	interferon	NN
cord-257027-q2y7fewk	208	6	-	-	HYPH
cord-257027-q2y7fewk	208	7	alpha	alpha	NN
cord-257027-q2y7fewk	208	8	and	and	CC
cord-257027-q2y7fewk	208	9	ribavirin	ribavirin	NN
cord-257027-q2y7fewk	208	10	therapy	therapy	NN
cord-257027-q2y7fewk	208	11	for	for	IN
cord-257027-q2y7fewk	208	12	chronic	chronic	JJ
cord-257027-q2y7fewk	208	13	hepatitis	hepatitis	NN
cord-257027-q2y7fewk	208	14	C	C	NNP
cord-257027-q2y7fewk	208	15	Genetic	genetic	JJ
cord-257027-q2y7fewk	208	16	variation	variation	NN
cord-257027-q2y7fewk	208	17	in	in	IN
cord-257027-q2y7fewk	208	18	IL28B	il28b	NN
cord-257027-q2y7fewk	208	19	and	and	CC
cord-257027-q2y7fewk	208	20	spontaneous	spontaneous	JJ
cord-257027-q2y7fewk	208	21	clearance	clearance	NN
cord-257027-q2y7fewk	208	22	of	of	IN
cord-257027-q2y7fewk	208	23	hepatitis	hepatitis	NN
cord-257027-q2y7fewk	208	24	C	C	NNP
cord-257027-q2y7fewk	208	25	virus	virus	NN
cord-257027-q2y7fewk	208	26	Heterogeneity	heterogeneity	NN
cord-257027-q2y7fewk	208	27	in	in	IN
cord-257027-q2y7fewk	208	28	vaccine	vaccine	NN
cord-257027-q2y7fewk	208	29	immune	immune	JJ
cord-257027-q2y7fewk	208	30	response	response	NN
cord-257027-q2y7fewk	208	31	:	:	:
cord-257027-q2y7fewk	208	32	the	the	DT
cord-257027-q2y7fewk	208	33	role	role	NN
cord-257027-q2y7fewk	208	34	of	of	IN
cord-257027-q2y7fewk	208	35	immunogenetics	immunogenetic	NNS
cord-257027-q2y7fewk	208	36	and	and	CC
cord-257027-q2y7fewk	208	37	the	the	DT
cord-257027-q2y7fewk	208	38	emerging	emerge	VBG
cord-257027-q2y7fewk	208	39	field	field	NN
cord-257027-q2y7fewk	208	40	of	of	IN
cord-257027-q2y7fewk	208	41	vaccinomics	vaccinomic	NNS
cord-257027-q2y7fewk	208	42	Differential	differential	JJ
cord-257027-q2y7fewk	208	43	genetic	genetic	JJ
cord-257027-q2y7fewk	208	44	determination	determination	NN
cord-257027-q2y7fewk	208	45	of	of	IN
cord-257027-q2y7fewk	208	46	immune	immune	JJ
cord-257027-q2y7fewk	208	47	responsiveness	responsiveness	NN
cord-257027-q2y7fewk	208	48	to	to	IN
cord-257027-q2y7fewk	208	49	hepatitis	hepatitis	NNP
cord-257027-q2y7fewk	208	50	B	B	NNP
cord-257027-q2y7fewk	208	51	surface	surface	NN
cord-257027-q2y7fewk	208	52	antigen	antigen	NN
cord-257027-q2y7fewk	208	53	and	and	CC
cord-257027-q2y7fewk	208	54	to	to	TO
cord-257027-q2y7fewk	208	55	hepatitis	hepatitis	VB
cord-257027-q2y7fewk	208	56	A	a	DT
cord-257027-q2y7fewk	208	57	virus	virus	NN
cord-257027-q2y7fewk	208	58	:	:	:
cord-257027-q2y7fewk	208	59	a	a	DT
cord-257027-q2y7fewk	208	60	vaccination	vaccination	NN
cord-257027-q2y7fewk	208	61	study	study	NN
cord-257027-q2y7fewk	208	62	in	in	IN
cord-257027-q2y7fewk	208	63	twins	twins	NNP
cord-257027-q2y7fewk	208	64	Genetic	genetic	JJ
cord-257027-q2y7fewk	208	65	regulation	regulation	NN
cord-257027-q2y7fewk	208	66	of	of	IN
cord-257027-q2y7fewk	208	67	immune	immune	JJ
cord-257027-q2y7fewk	208	68	responses	response	NNS
cord-257027-q2y7fewk	208	69	to	to	IN
cord-257027-q2y7fewk	208	70	vaccines	vaccine	NNS
cord-257027-q2y7fewk	208	71	in	in	IN
cord-257027-q2y7fewk	208	72	early	early	JJ
cord-257027-q2y7fewk	208	73	life	life	NN
cord-257027-q2y7fewk	209	1	Host	host	JJ
cord-257027-q2y7fewk	209	2	genetic	genetic	JJ
cord-257027-q2y7fewk	209	3	factors	factor	NNS
cord-257027-q2y7fewk	209	4	and	and	CC
cord-257027-q2y7fewk	209	5	vaccine	vaccine	NN
cord-257027-q2y7fewk	209	6	-	-	HYPH
cord-257027-q2y7fewk	209	7	induced	induce	VBN
cord-257027-q2y7fewk	209	8	immunity	immunity	NN
cord-257027-q2y7fewk	209	9	to	to	IN
cord-257027-q2y7fewk	209	10	hepatitis	hepatitis	NNP
cord-257027-q2y7fewk	209	11	B	B	NNP
cord-257027-q2y7fewk	209	12	virus	virus	NN
cord-257027-q2y7fewk	209	13	infection	infection	NN
cord-257027-q2y7fewk	210	1	The	the	DT
cord-257027-q2y7fewk	210	2	evolutionary	evolutionary	JJ
cord-257027-q2y7fewk	210	3	genomics	genomic	NNS
cord-257027-q2y7fewk	210	4	of	of	IN
cord-257027-q2y7fewk	210	5	pathogen	pathogen	NN
cord-257027-q2y7fewk	210	6	recombination	recombination	NN
cord-257027-q2y7fewk	210	7	Vaccine	Vaccine	NNP
cord-257027-q2y7fewk	210	8	immunogenetics	immunogenetic	NNS
cord-257027-q2y7fewk	210	9	:	:	:
cord-257027-q2y7fewk	210	10	bedside	bedside	NN
cord-257027-q2y7fewk	210	11	to	to	TO
cord-257027-q2y7fewk	210	12	bench	bench	VB
cord-257027-q2y7fewk	210	13	to	to	IN
cord-257027-q2y7fewk	210	14	population	population	NN
cord-257027-q2y7fewk	211	1	The	the	DT
cord-257027-q2y7fewk	211	2	lower	low	JJR
cord-257027-q2y7fewk	211	3	susceptibility	susceptibility	NN
cord-257027-q2y7fewk	211	4	to	to	IN
cord-257027-q2y7fewk	211	5	Plasmodium	plasmodium	NN
cord-257027-q2y7fewk	211	6	falciparum	falciparum	NN
cord-257027-q2y7fewk	211	7	malaria	malaria	NN
cord-257027-q2y7fewk	211	8	of	of	IN
cord-257027-q2y7fewk	211	9	Fulani	Fulani	NNP
cord-257027-q2y7fewk	211	10	of	of	IN
cord-257027-q2y7fewk	211	11	Burkina	Burkina	NNP
cord-257027-q2y7fewk	211	12	Faso	Faso	NNP
cord-257027-q2y7fewk	211	13	(	(	-LRB-
cord-257027-q2y7fewk	211	14	west	west	NNP
cord-257027-q2y7fewk	211	15	Africa	Africa	NNP
cord-257027-q2y7fewk	211	16	)	)	-RRB-
cord-257027-q2y7fewk	211	17	is	be	VBZ
cord-257027-q2y7fewk	211	18	associated	associate	VBN
cord-257027-q2y7fewk	211	19	with	with	IN
cord-257027-q2y7fewk	211	20	low	low	JJ
cord-257027-q2y7fewk	211	21	frequencies	frequency	NNS
cord-257027-q2y7fewk	211	22	of	of	IN
cord-257027-q2y7fewk	211	23	classic	classic	JJ
cord-257027-q2y7fewk	211	24	malaria	malaria	NN
cord-257027-q2y7fewk	211	25	-	-	HYPH
cord-257027-q2y7fewk	211	26	resistance	resistance	NN
cord-257027-q2y7fewk	211	27	genes	gene	NNS
cord-257027-q2y7fewk	211	28	Measles	Measles	NNP
cord-257027-q2y7fewk	211	29	antibody	antibody	NN
cord-257027-q2y7fewk	211	30	seroprevalence	seroprevalence	NN
cord-257027-q2y7fewk	211	31	rates	rate	NNS
cord-257027-q2y7fewk	211	32	among	among	IN
cord-257027-q2y7fewk	211	33	immunized	immunize	VBN
cord-257027-q2y7fewk	211	34	Inuit	Inuit	NNP
cord-257027-q2y7fewk	211	35	,	,	,
cord-257027-q2y7fewk	211	36	Innu	Innu	NNP
cord-257027-q2y7fewk	211	37	and	and	CC
cord-257027-q2y7fewk	211	38	Caucasian	caucasian	JJ
cord-257027-q2y7fewk	211	39	subjects	subject	NNS
cord-257027-q2y7fewk	211	40	BCG	BCG	NNP
cord-257027-q2y7fewk	211	41	-	-	HYPH
cord-257027-q2y7fewk	211	42	induced	induce	VBN
cord-257027-q2y7fewk	211	43	increase	increase	NN
cord-257027-q2y7fewk	211	44	in	in	IN
cord-257027-q2y7fewk	211	45	interferon	interferon	NN
cord-257027-q2y7fewk	211	46	-	-	HYPH
cord-257027-q2y7fewk	211	47	gamma	gamma	NN
cord-257027-q2y7fewk	211	48	response	response	NN
cord-257027-q2y7fewk	211	49	to	to	IN
cord-257027-q2y7fewk	211	50	mycobacterial	mycobacterial	NNP
cord-257027-q2y7fewk	211	51	antigens	antigen	NNS
cord-257027-q2y7fewk	211	52	and	and	CC
cord-257027-q2y7fewk	211	53	efficacy	efficacy	NN
cord-257027-q2y7fewk	211	54	of	of	IN
cord-257027-q2y7fewk	211	55	BCG	BCG	NNP
cord-257027-q2y7fewk	211	56	vaccination	vaccination	NN
cord-257027-q2y7fewk	211	57	in	in	IN
cord-257027-q2y7fewk	211	58	Malawi	Malawi	NNP
cord-257027-q2y7fewk	211	59	and	and	CC
cord-257027-q2y7fewk	211	60	the	the	DT
cord-257027-q2y7fewk	211	61	UK	UK	NNP
cord-257027-q2y7fewk	211	62	:	:	:
cord-257027-q2y7fewk	212	1	two	two	CD
cord-257027-q2y7fewk	212	2	randomised	randomised	JJ
cord-257027-q2y7fewk	212	3	controlled	control	VBN
cord-257027-q2y7fewk	212	4	studies	study	NNS
cord-257027-q2y7fewk	212	5	Reemergence	reemergence	NN
cord-257027-q2y7fewk	212	6	of	of	IN
cord-257027-q2y7fewk	212	7	invasive	invasive	JJ
cord-257027-q2y7fewk	212	8	Haemophilus	Haemophilus	NNP
cord-257027-q2y7fewk	212	9	influenzae	influenzae	NN
cord-257027-q2y7fewk	212	10	type	type	NN
cord-257027-q2y7fewk	212	11	b	b	NN
cord-257027-q2y7fewk	212	12	disease	disease	NN
cord-257027-q2y7fewk	212	13	in	in	IN
cord-257027-q2y7fewk	212	14	a	a	DT
cord-257027-q2y7fewk	212	15	well	well	RB
cord-257027-q2y7fewk	212	16	-	-	HYPH
cord-257027-q2y7fewk	212	17	vaccinated	vaccinate	VBN
cord-257027-q2y7fewk	212	18	population	population	NN
cord-257027-q2y7fewk	212	19	in	in	IN
cord-257027-q2y7fewk	212	20	remote	remote	JJ
cord-257027-q2y7fewk	212	21	Alaska	Alaska	NNP
cord-257027-q2y7fewk	212	22	Adversomics	Adversomics	NNP
cord-257027-q2y7fewk	212	23	:	:	:
cord-257027-q2y7fewk	212	24	the	the	DT
cord-257027-q2y7fewk	212	25	emerging	emerge	VBG
cord-257027-q2y7fewk	212	26	field	field	NN
cord-257027-q2y7fewk	212	27	of	of	IN
cord-257027-q2y7fewk	212	28	vaccine	vaccine	NN
cord-257027-q2y7fewk	212	29	adverse	adverse	JJ
cord-257027-q2y7fewk	212	30	event	event	NN
cord-257027-q2y7fewk	212	31	immunogenetics	immunogenetic	NNS
cord-257027-q2y7fewk	212	32	A	a	DT
cord-257027-q2y7fewk	212	33	framework	framework	NN
cord-257027-q2y7fewk	212	34	for	for	IN
cord-257027-q2y7fewk	212	35	variation	variation	NN
cord-257027-q2y7fewk	212	36	discovery	discovery	NN
cord-257027-q2y7fewk	212	37	and	and	CC
cord-257027-q2y7fewk	212	38	genotyping	genotyping	NN
cord-257027-q2y7fewk	212	39	using	use	VBG
cord-257027-q2y7fewk	212	40	next	next	JJ
cord-257027-q2y7fewk	212	41	-	-	HYPH
cord-257027-q2y7fewk	212	42	generation	generation	NN
cord-257027-q2y7fewk	212	43	DNA	dna	NN
cord-257027-q2y7fewk	212	44	sequencing	sequencing	NN
cord-257027-q2y7fewk	212	45	data	datum	NNS
cord-257027-q2y7fewk	212	46	A	a	DT
cord-257027-q2y7fewk	212	47	tutorial	tutorial	NN
cord-257027-q2y7fewk	212	48	on	on	IN
cord-257027-q2y7fewk	212	49	statistical	statistical	JJ
cord-257027-q2y7fewk	212	50	methods	method	NNS
cord-257027-q2y7fewk	212	51	for	for	IN
cord-257027-q2y7fewk	212	52	population	population	NNP
cord-257027-q2y7fewk	212	53	association	association	NNP
cord-257027-q2y7fewk	212	54	studies	study	NNS
cord-257027-q2y7fewk	212	55	How	how	WRB
cord-257027-q2y7fewk	212	56	malaria	malaria	NN
cord-257027-q2y7fewk	212	57	has	have	VBZ
cord-257027-q2y7fewk	212	58	affected	affect	VBN
cord-257027-q2y7fewk	212	59	the	the	DT
cord-257027-q2y7fewk	212	60	human	human	JJ
cord-257027-q2y7fewk	212	61	genome	genome	NN
cord-257027-q2y7fewk	212	62	and	and	CC
cord-257027-q2y7fewk	212	63	what	what	WDT
cord-257027-q2y7fewk	212	64	human	human	JJ
cord-257027-q2y7fewk	212	65	genetics	genetic	NNS
cord-257027-q2y7fewk	212	66	can	can	MD
cord-257027-q2y7fewk	212	67	teach	teach	VB
cord-257027-q2y7fewk	212	68	us	-PRON-	PRP
cord-257027-q2y7fewk	212	69	about	about	IN
cord-257027-q2y7fewk	212	70	malaria	malaria	NN
cord-257027-q2y7fewk	212	71	Prioritizing	prioritizing	NN
cord-257027-q2y7fewk	212	72	genes	gene	NNS
cord-257027-q2y7fewk	212	73	for	for	IN
cord-257027-q2y7fewk	212	74	pathway	pathway	NN
cord-257027-q2y7fewk	212	75	impact	impact	NN
cord-257027-q2y7fewk	212	76	using	use	VBG
cord-257027-q2y7fewk	212	77	network	network	NN
cord-257027-q2y7fewk	212	78	analysis	analysis	NN
cord-257027-q2y7fewk	212	79	Ectopic	ectopic	JJ
cord-257027-q2y7fewk	212	80	kidney	kidney	NN
cord-257027-q2y7fewk	212	81	with	with	IN
cord-257027-q2y7fewk	212	82	varied	varied	JJ
cord-257027-q2y7fewk	212	83	vasculature	vasculature	NN
cord-257027-q2y7fewk	212	84	:	:	:
cord-257027-q2y7fewk	212	85	demonstrated	demonstrate	VBN
cord-257027-q2y7fewk	212	86	by	by	IN
cord-257027-q2y7fewk	212	87	CT	CT	NNP
cord-257027-q2y7fewk	212	88	angiography	angiography	NN
cord-257027-q2y7fewk	213	1	The	the	DT
cord-257027-q2y7fewk	213	2	influence	influence	NN
cord-257027-q2y7fewk	213	3	of	of	IN
cord-257027-q2y7fewk	213	4	host	host	NN
cord-257027-q2y7fewk	213	5	and	and	CC
cord-257027-q2y7fewk	213	6	bacterial	bacterial	JJ
cord-257027-q2y7fewk	213	7	genotype	genotype	NN
cord-257027-q2y7fewk	213	8	on	on	IN
cord-257027-q2y7fewk	213	9	the	the	DT
cord-257027-q2y7fewk	213	10	development	development	NN
cord-257027-q2y7fewk	213	11	of	of	IN
cord-257027-q2y7fewk	213	12	disseminated	disseminate	VBN
cord-257027-q2y7fewk	213	13	disease	disease	NN
cord-257027-q2y7fewk	213	14	with	with	IN
cord-257027-q2y7fewk	213	15	Mycobacterium	Mycobacterium	NNP
cord-257027-q2y7fewk	213	16	tuberculosis	tuberculosis	NN
cord-257027-q2y7fewk	213	17	Interactome	Interactome	NNP
cord-257027-q2y7fewk	213	18	networks	network	NNS
cord-257027-q2y7fewk	213	19	and	and	CC
cord-257027-q2y7fewk	213	20	human	human	JJ
cord-257027-q2y7fewk	213	21	disease	disease	NN
cord-257027-q2y7fewk	213	22	Gene	Gene	NNP
cord-257027-q2y7fewk	213	23	expression	expression	NN
cord-257027-q2y7fewk	213	24	analysis	analysis	NN
cord-257027-q2y7fewk	213	25	reveals	reveal	VBZ
cord-257027-q2y7fewk	213	26	early	early	JJ
cord-257027-q2y7fewk	213	27	changes	change	NNS
cord-257027-q2y7fewk	213	28	in	in	IN
cord-257027-q2y7fewk	213	29	several	several	JJ
cord-257027-q2y7fewk	213	30	molecular	molecular	JJ
cord-257027-q2y7fewk	213	31	pathways	pathway	NNS
cord-257027-q2y7fewk	213	32	in	in	IN
cord-257027-q2y7fewk	213	33	cerebral	cerebral	JJ
cord-257027-q2y7fewk	213	34	malaria	malaria	NN
cord-257027-q2y7fewk	213	35	-	-	HYPH
cord-257027-q2y7fewk	213	36	susceptible	susceptible	JJ
cord-257027-q2y7fewk	213	37	mice	mouse	NNS
cord-257027-q2y7fewk	213	38	versus	versus	IN
cord-257027-q2y7fewk	213	39	cerebral	cerebral	JJ
cord-257027-q2y7fewk	213	40	malaria	malaria	NN
cord-257027-q2y7fewk	213	41	-	-	HYPH
cord-257027-q2y7fewk	213	42	resistant	resistant	JJ
cord-257027-q2y7fewk	213	43	mice	mouse	NNS
cord-257027-q2y7fewk	213	44	Gene	gene	NN
cord-257027-q2y7fewk	213	45	-	-	HYPH
cord-257027-q2y7fewk	213	46	expression	expression	NN
cord-257027-q2y7fewk	213	47	profiling	profiling	NN
cord-257027-q2y7fewk	213	48	discriminates	discriminate	NNS
cord-257027-q2y7fewk	213	49	between	between	IN
cord-257027-q2y7fewk	213	50	cerebral	cerebral	JJ
cord-257027-q2y7fewk	213	51	malaria	malaria	NN
cord-257027-q2y7fewk	213	52	(	(	-LRB-
cord-257027-q2y7fewk	213	53	CM)-susceptible	cm)-susceptible	CD
cord-257027-q2y7fewk	213	54	mice	mouse	NNS
cord-257027-q2y7fewk	213	55	and	and	CC
cord-257027-q2y7fewk	213	56	CM	cm	NN
cord-257027-q2y7fewk	213	57	-	-	HYPH
cord-257027-q2y7fewk	213	58	resistant	resistant	JJ
cord-257027-q2y7fewk	213	59	mice	mouse	NNS
cord-257027-q2y7fewk	213	60	Assessing	assess	VBG
cord-257027-q2y7fewk	213	61	the	the	DT
cord-257027-q2y7fewk	213	62	human	human	JJ
cord-257027-q2y7fewk	213	63	immune	immune	JJ
cord-257027-q2y7fewk	213	64	system	system	NN
cord-257027-q2y7fewk	213	65	through	through	IN
cord-257027-q2y7fewk	213	66	blood	blood	NN
cord-257027-q2y7fewk	213	67	transcriptomics	transcriptomic	NNS
cord-257027-q2y7fewk	213	68	Transcriptional	Transcriptional	NNP
cord-257027-q2y7fewk	213	69	profiling	profiling	NN
cord-257027-q2y7fewk	213	70	of	of	IN
cord-257027-q2y7fewk	213	71	mycobacterial	mycobacterial	JJ
cord-257027-q2y7fewk	213	72	antigen	antigen	NN
cord-257027-q2y7fewk	213	73	-	-	HYPH
cord-257027-q2y7fewk	213	74	induced	induce	VBN
cord-257027-q2y7fewk	213	75	responses	response	NNS
cord-257027-q2y7fewk	213	76	in	in	IN
cord-257027-q2y7fewk	213	77	infants	infant	NNS
cord-257027-q2y7fewk	213	78	vaccinated	vaccinate	VBN
cord-257027-q2y7fewk	213	79	with	with	IN
cord-257027-q2y7fewk	213	80	BCG	BCG	NNP
cord-257027-q2y7fewk	213	81	at	at	IN
cord-257027-q2y7fewk	213	82	birth	birth	NN
cord-257027-q2y7fewk	213	83	Curating	curate	VBG
cord-257027-q2y7fewk	213	84	the	the	DT
cord-257027-q2y7fewk	213	85	innate	innate	JJ
cord-257027-q2y7fewk	213	86	immunity	immunity	NN
cord-257027-q2y7fewk	213	87	interactome	interactome	NNP
cord-257027-q2y7fewk	214	1	Systems	system	NNS
cord-257027-q2y7fewk	214	2	biology	biology	NN
cord-257027-q2y7fewk	214	3	approaches	approach	NNS
cord-257027-q2y7fewk	214	4	to	to	IN
cord-257027-q2y7fewk	214	5	new	new	JJ
cord-257027-q2y7fewk	214	6	vaccine	vaccine	NN
cord-257027-q2y7fewk	214	7	development	development	NN
cord-257027-q2y7fewk	214	8	Systems	Systems	NNP
cord-257027-q2y7fewk	214	9	biology	biology	NN
cord-257027-q2y7fewk	214	10	approach	approach	NN
cord-257027-q2y7fewk	215	1	predicts	predict	VBZ
cord-257027-q2y7fewk	215	2	immunogenicity	immunogenicity	NN
cord-257027-q2y7fewk	215	3	of	of	IN
cord-257027-q2y7fewk	215	4	the	the	DT
cord-257027-q2y7fewk	215	5	yellow	yellow	JJ
cord-257027-q2y7fewk	215	6	fever	fever	NN
cord-257027-q2y7fewk	215	7	vaccine	vaccine	NN
cord-257027-q2y7fewk	215	8	in	in	IN
cord-257027-q2y7fewk	215	9	humans	human	NNS
cord-257027-q2y7fewk	215	10	Systems	Systems	NNP
cord-257027-q2y7fewk	215	11	biology	biology	NN
cord-257027-q2y7fewk	215	12	of	of	IN
cord-257027-q2y7fewk	215	13	vaccination	vaccination	NN
cord-257027-q2y7fewk	215	14	for	for	IN
cord-257027-q2y7fewk	215	15	seasonal	seasonal	JJ
cord-257027-q2y7fewk	215	16	influenza	influenza	NN
cord-257027-q2y7fewk	215	17	in	in	IN
cord-257027-q2y7fewk	215	18	humans	human	NNS