id	sid	tid	token	lemma	pos
cord-018265-twp33bb6	1	1	key	key	NNP
cord-018265-twp33bb6	1	2	:	:	:
cord-018265-twp33bb6	1	3	cord-018265-twp33bb6	cord-018265-twp33bb6	.
cord-018265-twp33bb6	2	1	authors	author	NNS
cord-018265-twp33bb6	2	2	:	:	:
cord-018265-twp33bb6	2	3	Becker	Becker	NNP
cord-018265-twp33bb6	2	4	,	,	,
cord-018265-twp33bb6	2	5	Pablo	Pablo	NNP
cord-018265-twp33bb6	2	6	D.	D.	NNP
cord-018265-twp33bb6	2	7	;	;	:
cord-018265-twp33bb6	2	8	Guzmán	Guzmán	NNP
cord-018265-twp33bb6	2	9	,	,	,
cord-018265-twp33bb6	2	10	Carlos	Carlos	NNP
cord-018265-twp33bb6	2	11	A.	a.	NN
cord-018265-twp33bb6	2	12	title	title	NN
cord-018265-twp33bb6	2	13	:	:	:
cord-018265-twp33bb6	3	1	Community	community	NN
cord-018265-twp33bb6	3	2	-	-	HYPH
cord-018265-twp33bb6	3	3	acquired	acquire	VBN
cord-018265-twp33bb6	3	4	pneumonia	pneumonia	NN
cord-018265-twp33bb6	3	5	:	:	:
cord-018265-twp33bb6	3	6	paving	pave	VBG
cord-018265-twp33bb6	3	7	the	the	DT
cord-018265-twp33bb6	3	8	way	way	NN
cord-018265-twp33bb6	3	9	towards	towards	IN
cord-018265-twp33bb6	3	10	new	new	JJ
cord-018265-twp33bb6	3	11	vaccination	vaccination	NN
cord-018265-twp33bb6	3	12	concepts	concept	NNS
cord-018265-twp33bb6	3	13	date	date	NN
cord-018265-twp33bb6	3	14	:	:	:
cord-018265-twp33bb6	4	1	2007	2007	CD
cord-018265-twp33bb6	4	2	journal	journal	NNP
cord-018265-twp33bb6	4	3	:	:	:
cord-018265-twp33bb6	5	1	Community	community	NN
cord-018265-twp33bb6	5	2	-	-	HYPH
cord-018265-twp33bb6	5	3	Acquired	Acquired	NNP
cord-018265-twp33bb6	5	4	Pneumonia	Pneumonia	NNP
cord-018265-twp33bb6	5	5	DOI	DOI	NNP
cord-018265-twp33bb6	5	6	:	:	:
cord-018265-twp33bb6	5	7	10.1007/978	10.1007/978	CD
cord-018265-twp33bb6	5	8	-	-	HYPH
cord-018265-twp33bb6	5	9	3	3	CD
cord-018265-twp33bb6	5	10	-	-	HYPH
cord-018265-twp33bb6	5	11	7643	7643	CD
cord-018265-twp33bb6	5	12	-	-	HYPH
cord-018265-twp33bb6	5	13	7563	7563	CD
cord-018265-twp33bb6	5	14	-	-	HYPH
cord-018265-twp33bb6	5	15	8_10	8_10	CD
cord-018265-twp33bb6	6	1	sha	sha	NNP
cord-018265-twp33bb6	6	2	:	:	:
cord-018265-twp33bb6	7	1	a3541fda5120cf0c3346777d6077a5e2e73d78fd	a3541fda5120cf0c3346777d6077a5e2e73d78fd	NNS
cord-018265-twp33bb6	7	2	doc_id	doc_id	CD
cord-018265-twp33bb6	7	3	:	:	:
cord-018265-twp33bb6	8	1	18265	18265	CD
cord-018265-twp33bb6	8	2	cord_uid	cord_uid	NN
cord-018265-twp33bb6	8	3	:	:	:
cord-018265-twp33bb6	8	4	twp33bb6	twp33bb6	ADD
cord-018265-twp33bb6	9	1	Despite	despite	IN
cord-018265-twp33bb6	9	2	the	the	DT
cord-018265-twp33bb6	9	3	availability	availability	NN
cord-018265-twp33bb6	9	4	of	of	IN
cord-018265-twp33bb6	9	5	antimicrobial	antimicrobial	JJ
cord-018265-twp33bb6	9	6	agents	agent	NNS
cord-018265-twp33bb6	9	7	and	and	CC
cord-018265-twp33bb6	9	8	vaccines	vaccine	NNS
cord-018265-twp33bb6	9	9	,	,	,
cord-018265-twp33bb6	9	10	community	community	NN
cord-018265-twp33bb6	9	11	-	-	HYPH
cord-018265-twp33bb6	9	12	acquired	acquire	VBN
cord-018265-twp33bb6	9	13	pneumonia	pneumonia	NN
cord-018265-twp33bb6	9	14	remains	remain	VBZ
cord-018265-twp33bb6	9	15	a	a	DT
cord-018265-twp33bb6	9	16	serious	serious	JJ
cord-018265-twp33bb6	9	17	problem	problem	NN
cord-018265-twp33bb6	9	18	.	.	.
cord-018265-twp33bb6	10	1	Severe	severe	JJ
cord-018265-twp33bb6	10	2	forms	form	NNS
cord-018265-twp33bb6	10	3	tend	tend	VBP
cord-018265-twp33bb6	10	4	to	to	TO
cord-018265-twp33bb6	10	5	occur	occur	VB
cord-018265-twp33bb6	10	6	in	in	IN
cord-018265-twp33bb6	10	7	very	very	RB
cord-018265-twp33bb6	10	8	young	young	JJ
cord-018265-twp33bb6	10	9	children	child	NNS
cord-018265-twp33bb6	10	10	and	and	CC
cord-018265-twp33bb6	10	11	among	among	IN
cord-018265-twp33bb6	10	12	the	the	DT
cord-018265-twp33bb6	10	13	elderly	elderly	JJ
cord-018265-twp33bb6	10	14	,	,	,
cord-018265-twp33bb6	10	15	since	since	IN
cord-018265-twp33bb6	10	16	their	-PRON-	PRP$
cord-018265-twp33bb6	10	17	immune	immune	JJ
cord-018265-twp33bb6	10	18	competence	competence	NN
cord-018265-twp33bb6	10	19	is	be	VBZ
cord-018265-twp33bb6	10	20	eroded	erode	VBN
cord-018265-twp33bb6	10	21	by	by	IN
cord-018265-twp33bb6	10	22	immaturity	immaturity	NN
cord-018265-twp33bb6	10	23	and	and	CC
cord-018265-twp33bb6	10	24	immune	immune	JJ
cord-018265-twp33bb6	10	25	senescence	senescence	NN
cord-018265-twp33bb6	10	26	,	,	,
cord-018265-twp33bb6	10	27	respectively	respectively	RB
cord-018265-twp33bb6	10	28	.	.	.
cord-018265-twp33bb6	11	1	The	the	DT
cord-018265-twp33bb6	11	2	main	main	JJ
cord-018265-twp33bb6	11	3	etiologic	etiologic	JJ
cord-018265-twp33bb6	11	4	agents	agent	NNS
cord-018265-twp33bb6	11	5	differ	differ	VBP
cord-018265-twp33bb6	11	6	according	accord	VBG
cord-018265-twp33bb6	11	7	to	to	IN
cord-018265-twp33bb6	11	8	patient	patient	JJ
cord-018265-twp33bb6	11	9	age	age	NN
cord-018265-twp33bb6	11	10	and	and	CC
cord-018265-twp33bb6	11	11	geographic	geographic	JJ
cord-018265-twp33bb6	11	12	area	area	NN
cord-018265-twp33bb6	11	13	.	.	.
cord-018265-twp33bb6	12	1	Streptococcus	streptococcus	NN
cord-018265-twp33bb6	12	2	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	12	3	,	,	,
cord-018265-twp33bb6	12	4	Haemophilus	haemophilus	JJ
cord-018265-twp33bb6	12	5	influenzae	influenzae	NN
cord-018265-twp33bb6	12	6	,	,	,
cord-018265-twp33bb6	12	7	respiratory	respiratory	JJ
cord-018265-twp33bb6	12	8	syncytial	syncytial	JJ
cord-018265-twp33bb6	12	9	virus	virus	NN
cord-018265-twp33bb6	12	10	(	(	-LRB-
cord-018265-twp33bb6	12	11	RSV	RSV	NNP
cord-018265-twp33bb6	12	12	)	)	-RRB-
cord-018265-twp33bb6	12	13	and	and	CC
cord-018265-twp33bb6	12	14	parainfluenza	parainfluenza	NNP
cord-018265-twp33bb6	12	15	virus	virus	NNP
cord-018265-twp33bb6	12	16	type	type	NNP
cord-018265-twp33bb6	12	17	3	3	CD
cord-018265-twp33bb6	12	18	(	(	-LRB-
cord-018265-twp33bb6	12	19	PIV-3	PIV-3	NNP
cord-018265-twp33bb6	12	20	)	)	-RRB-
cord-018265-twp33bb6	12	21	are	be	VBP
cord-018265-twp33bb6	12	22	the	the	DT
cord-018265-twp33bb6	12	23	most	most	RBS
cord-018265-twp33bb6	12	24	important	important	JJ
cord-018265-twp33bb6	12	25	pathogens	pathogen	NNS
cord-018265-twp33bb6	12	26	in	in	IN
cord-018265-twp33bb6	12	27	children	child	NNS
cord-018265-twp33bb6	12	28	,	,	,
cord-018265-twp33bb6	12	29	whereas	whereas	IN
cord-018265-twp33bb6	12	30	influenza	influenza	NN
cord-018265-twp33bb6	12	31	viruses	virus	NNS
cord-018265-twp33bb6	12	32	are	be	VBP
cord-018265-twp33bb6	12	33	the	the	DT
cord-018265-twp33bb6	12	34	leading	leading	JJ
cord-018265-twp33bb6	12	35	cause	cause	NN
cord-018265-twp33bb6	12	36	of	of	IN
cord-018265-twp33bb6	12	37	fatal	fatal	JJ
cord-018265-twp33bb6	12	38	pneumonia	pneumonia	NN
cord-018265-twp33bb6	12	39	in	in	IN
cord-018265-twp33bb6	12	40	the	the	DT
cord-018265-twp33bb6	12	41	elderly	elderly	JJ
cord-018265-twp33bb6	12	42	.	.	.
cord-018265-twp33bb6	13	1	Effective	effective	JJ
cord-018265-twp33bb6	13	2	vaccines	vaccine	NNS
cord-018265-twp33bb6	13	3	are	be	VBP
cord-018265-twp33bb6	13	4	available	available	JJ
cord-018265-twp33bb6	13	5	against	against	IN
cord-018265-twp33bb6	13	6	some	some	DT
cord-018265-twp33bb6	13	7	of	of	IN
cord-018265-twp33bb6	13	8	these	these	DT
cord-018265-twp33bb6	13	9	organisms	organism	NNS
cord-018265-twp33bb6	13	10	.	.	.
cord-018265-twp33bb6	14	1	However	however	RB
cord-018265-twp33bb6	14	2	,	,	,
cord-018265-twp33bb6	14	3	there	there	EX
cord-018265-twp33bb6	14	4	are	be	VBP
cord-018265-twp33bb6	14	5	still	still	RB
cord-018265-twp33bb6	14	6	many	many	JJ
cord-018265-twp33bb6	14	7	agents	agent	NNS
cord-018265-twp33bb6	14	8	against	against	IN
cord-018265-twp33bb6	14	9	which	which	WDT
cord-018265-twp33bb6	14	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	14	11	are	be	VBP
cord-018265-twp33bb6	14	12	not	not	RB
cord-018265-twp33bb6	14	13	available	available	JJ
cord-018265-twp33bb6	14	14	or	or	CC
cord-018265-twp33bb6	14	15	the	the	DT
cord-018265-twp33bb6	14	16	existent	existent	JJ
cord-018265-twp33bb6	14	17	ones	one	NNS
cord-018265-twp33bb6	14	18	are	be	VBP
cord-018265-twp33bb6	14	19	suboptimal	suboptimal	JJ
cord-018265-twp33bb6	14	20	.	.	.
cord-018265-twp33bb6	15	1	To	to	TO
cord-018265-twp33bb6	15	2	tackle	tackle	VB
cord-018265-twp33bb6	15	3	this	this	DT
cord-018265-twp33bb6	15	4	problem	problem	NN
cord-018265-twp33bb6	15	5	,	,	,
cord-018265-twp33bb6	15	6	empiric	empiric	JJ
cord-018265-twp33bb6	15	7	approaches	approach	NNS
cord-018265-twp33bb6	15	8	are	be	VBP
cord-018265-twp33bb6	15	9	now	now	RB
cord-018265-twp33bb6	15	10	being	be	VBG
cord-018265-twp33bb6	15	11	systematically	systematically	RB
cord-018265-twp33bb6	15	12	replaced	replace	VBN
cord-018265-twp33bb6	15	13	by	by	IN
cord-018265-twp33bb6	15	14	rational	rational	JJ
cord-018265-twp33bb6	15	15	vaccine	vaccine	NN
cord-018265-twp33bb6	15	16	design	design	NN
cord-018265-twp33bb6	15	17	.	.	.
cord-018265-twp33bb6	16	1	This	this	DT
cord-018265-twp33bb6	16	2	is	be	VBZ
cord-018265-twp33bb6	16	3	facilitated	facilitate	VBN
cord-018265-twp33bb6	16	4	by	by	IN
cord-018265-twp33bb6	16	5	the	the	DT
cord-018265-twp33bb6	16	6	growing	grow	VBG
cord-018265-twp33bb6	16	7	knowledge	knowledge	NN
cord-018265-twp33bb6	16	8	in	in	IN
cord-018265-twp33bb6	16	9	the	the	DT
cord-018265-twp33bb6	16	10	fields	field	NNS
cord-018265-twp33bb6	16	11	of	of	IN
cord-018265-twp33bb6	16	12	immunology	immunology	NN
cord-018265-twp33bb6	16	13	,	,	,
cord-018265-twp33bb6	16	14	microbial	microbial	JJ
cord-018265-twp33bb6	16	15	pathogenesis	pathogenesis	NN
cord-018265-twp33bb6	16	16	and	and	CC
cord-018265-twp33bb6	16	17	host	host	NN
cord-018265-twp33bb6	16	18	response	response	NN
cord-018265-twp33bb6	16	19	to	to	IN
cord-018265-twp33bb6	16	20	infection	infection	NN
cord-018265-twp33bb6	16	21	,	,	,
cord-018265-twp33bb6	16	22	as	as	RB
cord-018265-twp33bb6	16	23	well	well	RB
cord-018265-twp33bb6	16	24	as	as	IN
cord-018265-twp33bb6	16	25	by	by	IN
cord-018265-twp33bb6	16	26	the	the	DT
cord-018265-twp33bb6	16	27	availability	availability	NN
cord-018265-twp33bb6	16	28	of	of	IN
cord-018265-twp33bb6	16	29	sophisticated	sophisticated	JJ
cord-018265-twp33bb6	16	30	strategies	strategy	NNS
cord-018265-twp33bb6	16	31	for	for	IN
cord-018265-twp33bb6	16	32	antigen	antigen	NN
cord-018265-twp33bb6	16	33	selection	selection	NN
cord-018265-twp33bb6	16	34	,	,	,
cord-018265-twp33bb6	16	35	potent	potent	JJ
cord-018265-twp33bb6	16	36	immune	immune	JJ
cord-018265-twp33bb6	16	37	modulators	modulator	NNS
cord-018265-twp33bb6	16	38	and	and	CC
cord-018265-twp33bb6	16	39	efficient	efficient	JJ
cord-018265-twp33bb6	16	40	antigen	antigen	NN
cord-018265-twp33bb6	16	41	delivery	delivery	NN
cord-018265-twp33bb6	16	42	systems	system	NNS
cord-018265-twp33bb6	16	43	.	.	.
cord-018265-twp33bb6	17	1	Thus	thus	RB
cord-018265-twp33bb6	17	2	,	,	,
cord-018265-twp33bb6	17	3	a	a	DT
cord-018265-twp33bb6	17	4	new	new	JJ
cord-018265-twp33bb6	17	5	generation	generation	NN
cord-018265-twp33bb6	17	6	of	of	IN
cord-018265-twp33bb6	17	7	vaccines	vaccine	NNS
cord-018265-twp33bb6	17	8	with	with	IN
cord-018265-twp33bb6	17	9	improved	improved	JJ
cord-018265-twp33bb6	17	10	safety	safety	NN
cord-018265-twp33bb6	17	11	and	and	CC
cord-018265-twp33bb6	17	12	efficacy	efficacy	NN
cord-018265-twp33bb6	17	13	profiles	profile	NNS
cord-018265-twp33bb6	17	14	compared	compare	VBN
cord-018265-twp33bb6	17	15	to	to	IN
cord-018265-twp33bb6	17	16	old	old	JJ
cord-018265-twp33bb6	17	17	and	and	CC
cord-018265-twp33bb6	17	18	new	new	JJ
cord-018265-twp33bb6	17	19	agents	agent	NNS
cord-018265-twp33bb6	17	20	is	be	VBZ
cord-018265-twp33bb6	17	21	emerging	emerge	VBG
cord-018265-twp33bb6	17	22	.	.	.
cord-018265-twp33bb6	18	1	In	in	IN
cord-018265-twp33bb6	18	2	this	this	DT
cord-018265-twp33bb6	18	3	chapter	chapter	NN
cord-018265-twp33bb6	18	4	,	,	,
cord-018265-twp33bb6	18	5	an	an	DT
cord-018265-twp33bb6	18	6	overview	overview	NN
cord-018265-twp33bb6	18	7	is	be	VBZ
cord-018265-twp33bb6	18	8	provided	provide	VBN
cord-018265-twp33bb6	18	9	about	about	IN
cord-018265-twp33bb6	18	10	currently	currently	RB
cord-018265-twp33bb6	18	11	available	available	JJ
cord-018265-twp33bb6	18	12	and	and	CC
cord-018265-twp33bb6	18	13	new	new	JJ
cord-018265-twp33bb6	18	14	vaccination	vaccination	NN
cord-018265-twp33bb6	18	15	concepts	concept	NNS
cord-018265-twp33bb6	18	16	.	.	.
cord-018265-twp33bb6	19	1	The	the	DT
cord-018265-twp33bb6	19	2	mucosa	mucosa	NN
cord-018265-twp33bb6	19	3	of	of	IN
cord-018265-twp33bb6	19	4	the	the	DT
cord-018265-twp33bb6	19	5	human	human	JJ
cord-018265-twp33bb6	19	6	respiratory	respiratory	JJ
cord-018265-twp33bb6	19	7	tract	tract	NN
cord-018265-twp33bb6	19	8	represents	represent	VBZ
cord-018265-twp33bb6	19	9	a	a	DT
cord-018265-twp33bb6	19	10	primary	primary	JJ
cord-018265-twp33bb6	19	11	target	target	NN
cord-018265-twp33bb6	19	12	for	for	IN
cord-018265-twp33bb6	19	13	a	a	DT
cord-018265-twp33bb6	19	14	large	large	JJ
cord-018265-twp33bb6	19	15	number	number	NN
cord-018265-twp33bb6	19	16	of	of	IN
cord-018265-twp33bb6	19	17	microbial	microbial	JJ
cord-018265-twp33bb6	19	18	pathogens	pathogen	NNS
cord-018265-twp33bb6	19	19	.	.	.
cord-018265-twp33bb6	20	1	Typically	typically	RB
cord-018265-twp33bb6	20	2	,	,	,
cord-018265-twp33bb6	20	3	colonization	colonization	NN
cord-018265-twp33bb6	20	4	is	be	VBZ
cord-018265-twp33bb6	20	5	an	an	DT
cord-018265-twp33bb6	20	6	asymptomatic	asymptomatic	JJ
cord-018265-twp33bb6	20	7	process	process	NN
cord-018265-twp33bb6	20	8	,	,	,
cord-018265-twp33bb6	20	9	resulting	result	VBG
cord-018265-twp33bb6	20	10	from	from	IN
cord-018265-twp33bb6	20	11	the	the	DT
cord-018265-twp33bb6	20	12	interplay	interplay	NN
cord-018265-twp33bb6	20	13	between	between	IN
cord-018265-twp33bb6	20	14	bacterial	bacterial	JJ
cord-018265-twp33bb6	20	15	factors	factor	NNS
cord-018265-twp33bb6	20	16	and	and	CC
cord-018265-twp33bb6	20	17	host	host	NN
cord-018265-twp33bb6	20	18	clearance	clearance	NN
cord-018265-twp33bb6	20	19	mechanisms	mechanism	NNS
cord-018265-twp33bb6	20	20	.	.	.
cord-018265-twp33bb6	21	1	Clinical	clinical	JJ
cord-018265-twp33bb6	21	2	illness	illness	NN
cord-018265-twp33bb6	21	3	may	may	MD
cord-018265-twp33bb6	21	4	result	result	VB
cord-018265-twp33bb6	21	5	from	from	IN
cord-018265-twp33bb6	21	6	either	either	CC
cord-018265-twp33bb6	21	7	the	the	DT
cord-018265-twp33bb6	21	8	local	local	JJ
cord-018265-twp33bb6	21	9	release	release	NN
cord-018265-twp33bb6	21	10	of	of	IN
cord-018265-twp33bb6	21	11	bacterial	bacterial	JJ
cord-018265-twp33bb6	21	12	toxins	toxin	NNS
cord-018265-twp33bb6	21	13	or	or	CC
cord-018265-twp33bb6	21	14	the	the	DT
cord-018265-twp33bb6	21	15	systemic	systemic	JJ
cord-018265-twp33bb6	21	16	dissemination	dissemination	NN
cord-018265-twp33bb6	21	17	of	of	IN
cord-018265-twp33bb6	21	18	the	the	DT
cord-018265-twp33bb6	21	19	pathogen	pathogen	NN
cord-018265-twp33bb6	21	20	after	after	IN
cord-018265-twp33bb6	21	21	breaching	breach	VBG
cord-018265-twp33bb6	21	22	the	the	DT
cord-018265-twp33bb6	21	23	mucosal	mucosal	JJ
cord-018265-twp33bb6	21	24	barrier	barrier	NN
cord-018265-twp33bb6	21	25	.	.	.
cord-018265-twp33bb6	22	1	In	in	IN
cord-018265-twp33bb6	22	2	the	the	DT
cord-018265-twp33bb6	22	3	course	course	NN
cord-018265-twp33bb6	22	4	of	of	IN
cord-018265-twp33bb6	22	5	respiratory	respiratory	JJ
cord-018265-twp33bb6	22	6	infections	infection	NNS
cord-018265-twp33bb6	22	7	adaptive	adaptive	JJ
cord-018265-twp33bb6	22	8	immune	immune	JJ
cord-018265-twp33bb6	22	9	responses	response	NNS
cord-018265-twp33bb6	22	10	could	could	MD
cord-018265-twp33bb6	22	11	be	be	VB
cord-018265-twp33bb6	22	12	significantly	significantly	RB
cord-018265-twp33bb6	22	13	impaired	impair	VBN
cord-018265-twp33bb6	22	14	.	.	.
cord-018265-twp33bb6	23	1	This	this	DT
cord-018265-twp33bb6	23	2	might	may	MD
cord-018265-twp33bb6	23	3	lead	lead	VB
cord-018265-twp33bb6	23	4	to	to	IN
cord-018265-twp33bb6	23	5	more	more	RBR
cord-018265-twp33bb6	23	6	severe	severe	JJ
cord-018265-twp33bb6	23	7	forms	form	NNS
cord-018265-twp33bb6	23	8	of	of	IN
cord-018265-twp33bb6	23	9	disease	disease	NN
cord-018265-twp33bb6	23	10	or	or	CC
cord-018265-twp33bb6	23	11	to	to	IN
cord-018265-twp33bb6	23	12	super	super	VB
cord-018265-twp33bb6	23	13	-	-	NNS
cord-018265-twp33bb6	23	14	infections	infection	NNS
cord-018265-twp33bb6	23	15	,	,	,
cord-018265-twp33bb6	23	16	which	which	WDT
cord-018265-twp33bb6	23	17	in	in	IN
cord-018265-twp33bb6	23	18	turn	turn	NN
cord-018265-twp33bb6	23	19	complicate	complicate	VBP
cord-018265-twp33bb6	23	20	the	the	DT
cord-018265-twp33bb6	23	21	clinical	clinical	JJ
cord-018265-twp33bb6	23	22	management	management	NN
cord-018265-twp33bb6	23	23	of	of	IN
cord-018265-twp33bb6	23	24	the	the	DT
cord-018265-twp33bb6	23	25	patient	patient	NN
cord-018265-twp33bb6	23	26	.	.	.
cord-018265-twp33bb6	24	1	The	the	DT
cord-018265-twp33bb6	24	2	most	most	RBS
cord-018265-twp33bb6	24	3	severe	severe	JJ
cord-018265-twp33bb6	24	4	forms	form	NNS
cord-018265-twp33bb6	24	5	of	of	IN
cord-018265-twp33bb6	24	6	respiratory	respiratory	JJ
cord-018265-twp33bb6	24	7	infection	infection	NN
cord-018265-twp33bb6	24	8	tend	tend	VBP
cord-018265-twp33bb6	24	9	to	to	TO
cord-018265-twp33bb6	24	10	occur	occur	VB
cord-018265-twp33bb6	24	11	in	in	IN
cord-018265-twp33bb6	24	12	very	very	RB
cord-018265-twp33bb6	24	13	young	young	JJ
cord-018265-twp33bb6	24	14	children	child	NNS
cord-018265-twp33bb6	24	15	and	and	CC
cord-018265-twp33bb6	24	16	among	among	IN
cord-018265-twp33bb6	24	17	the	the	DT
cord-018265-twp33bb6	24	18	elderly	elderly	JJ
cord-018265-twp33bb6	24	19	,	,	,
cord-018265-twp33bb6	24	20	in	in	IN
cord-018265-twp33bb6	24	21	whom	whom	WP
cord-018265-twp33bb6	24	22	immune	immune	JJ
cord-018265-twp33bb6	24	23	competence	competence	NN
cord-018265-twp33bb6	24	24	is	be	VBZ
cord-018265-twp33bb6	24	25	eroded	erode	VBN
cord-018265-twp33bb6	24	26	by	by	IN
cord-018265-twp33bb6	24	27	immaturity	immaturity	NN
cord-018265-twp33bb6	24	28	or	or	CC
cord-018265-twp33bb6	24	29	immunesenescence	immunesenescence	NN
cord-018265-twp33bb6	24	30	,	,	,
cord-018265-twp33bb6	24	31	respectively	respectively	RB
cord-018265-twp33bb6	24	32	.	.	.
cord-018265-twp33bb6	25	1	In	in	IN
cord-018265-twp33bb6	25	2	addition	addition	NN
cord-018265-twp33bb6	25	3	,	,	,
cord-018265-twp33bb6	25	4	patients	patient	NNS
cord-018265-twp33bb6	25	5	who	who	WP
cord-018265-twp33bb6	25	6	are	be	VBP
cord-018265-twp33bb6	25	7	immunocompromised	immunocompromised	JJ
cord-018265-twp33bb6	25	8	,	,	,
cord-018265-twp33bb6	25	9	as	as	IN
cord-018265-twp33bb6	25	10	a	a	DT
cord-018265-twp33bb6	25	11	result	result	NN
cord-018265-twp33bb6	25	12	of	of	IN
cord-018265-twp33bb6	25	13	disease	disease	NN
cord-018265-twp33bb6	25	14	or	or	CC
cord-018265-twp33bb6	25	15	therapeutic	therapeutic	JJ
cord-018265-twp33bb6	25	16	interventions	intervention	NNS
cord-018265-twp33bb6	25	17	,	,	,
cord-018265-twp33bb6	25	18	have	have	VBP
cord-018265-twp33bb6	25	19	the	the	DT
cord-018265-twp33bb6	25	20	greatest	great	JJS
cord-018265-twp33bb6	25	21	risk	risk	NN
cord-018265-twp33bb6	25	22	of	of	IN
cord-018265-twp33bb6	25	23	developing	develop	VBG
cord-018265-twp33bb6	25	24	a	a	DT
cord-018265-twp33bb6	25	25	fatal	fatal	JJ
cord-018265-twp33bb6	25	26	infection	infection	NN
cord-018265-twp33bb6	25	27	.	.	.
cord-018265-twp33bb6	26	1	Despite	despite	IN
cord-018265-twp33bb6	26	2	the	the	DT
cord-018265-twp33bb6	26	3	availability	availability	NN
cord-018265-twp33bb6	26	4	of	of	IN
cord-018265-twp33bb6	26	5	new	new	JJ
cord-018265-twp33bb6	26	6	antimicrobials	antimicrobial	NNS
cord-018265-twp33bb6	26	7	and	and	CC
cord-018265-twp33bb6	26	8	effective	effective	JJ
cord-018265-twp33bb6	26	9	vaccines	vaccine	NNS
cord-018265-twp33bb6	26	10	,	,	,
cord-018265-twp33bb6	26	11	community	community	NN
cord-018265-twp33bb6	26	12	-	-	HYPH
cord-018265-twp33bb6	26	13	acquired	acquire	VBN
cord-018265-twp33bb6	26	14	pneumonia	pneumonia	NN
cord-018265-twp33bb6	26	15	remains	remain	VBZ
cord-018265-twp33bb6	26	16	a	a	DT
cord-018265-twp33bb6	26	17	common	common	JJ
cord-018265-twp33bb6	26	18	and	and	CC
cord-018265-twp33bb6	26	19	serious	serious	JJ
cord-018265-twp33bb6	26	20	illness	illness	NN
cord-018265-twp33bb6	26	21	.	.	.
cord-018265-twp33bb6	27	1	In	in	IN
cord-018265-twp33bb6	27	2	fact	fact	NN
cord-018265-twp33bb6	27	3	,	,	,
cord-018265-twp33bb6	27	4	it	-PRON-	PRP
cord-018265-twp33bb6	27	5	is	be	VBZ
cord-018265-twp33bb6	27	6	a	a	DT
cord-018265-twp33bb6	27	7	leading	lead	VBG
cord-018265-twp33bb6	27	8	contributor	contributor	NN
cord-018265-twp33bb6	27	9	to	to	IN
cord-018265-twp33bb6	27	10	the	the	DT
cord-018265-twp33bb6	27	11	nearly	nearly	RB
cord-018265-twp33bb6	27	12	4	4	CD
cord-018265-twp33bb6	27	13	million	million	CD
cord-018265-twp33bb6	27	14	deaths	death	NNS
cord-018265-twp33bb6	27	15	occurring	occur	VBG
cord-018265-twp33bb6	27	16	each	each	DT
cord-018265-twp33bb6	27	17	year	year	NN
cord-018265-twp33bb6	27	18	due	due	IN
cord-018265-twp33bb6	27	19	to	to	IN
cord-018265-twp33bb6	27	20	respiratory	respiratory	JJ
cord-018265-twp33bb6	27	21	infections	infection	NNS
cord-018265-twp33bb6	27	22	,	,	,
cord-018265-twp33bb6	27	23	especially	especially	RB
cord-018265-twp33bb6	27	24	in	in	IN
cord-018265-twp33bb6	27	25	children	child	NNS
cord-018265-twp33bb6	27	26	from	from	IN
cord-018265-twp33bb6	27	27	developing	develop	VBG
cord-018265-twp33bb6	27	28	countries	country	NNS
cord-018265-twp33bb6	27	29	[	[	-LRB-
cord-018265-twp33bb6	27	30	1	1	CD
cord-018265-twp33bb6	27	31	,	,	,
cord-018265-twp33bb6	27	32	2	2	CD
cord-018265-twp33bb6	27	33	]	]	-RRB-
cord-018265-twp33bb6	27	34	.	.	.
cord-018265-twp33bb6	28	1	The	the	DT
cord-018265-twp33bb6	28	2	main	main	JJ
cord-018265-twp33bb6	28	3	causative	causative	JJ
cord-018265-twp33bb6	28	4	agents	agent	NNS
cord-018265-twp33bb6	28	5	of	of	IN
cord-018265-twp33bb6	28	6	pneumonia	pneumonia	NN
cord-018265-twp33bb6	28	7	differ	differ	VBP
cord-018265-twp33bb6	28	8	according	accord	VBG
cord-018265-twp33bb6	28	9	to	to	IN
cord-018265-twp33bb6	28	10	the	the	DT
cord-018265-twp33bb6	28	11	patient	patient	NN
cord-018265-twp33bb6	28	12	age	age	NN
cord-018265-twp33bb6	28	13	and	and	CC
cord-018265-twp33bb6	28	14	the	the	DT
cord-018265-twp33bb6	28	15	geographic	geographic	JJ
cord-018265-twp33bb6	28	16	area	area	NN
cord-018265-twp33bb6	28	17	.	.	.
cord-018265-twp33bb6	29	1	In	in	IN
cord-018265-twp33bb6	29	2	addition	addition	NN
cord-018265-twp33bb6	29	3	,	,	,
cord-018265-twp33bb6	29	4	there	there	EX
cord-018265-twp33bb6	29	5	are	be	VBP
cord-018265-twp33bb6	29	6	relatively	relatively	RB
cord-018265-twp33bb6	29	7	few	few	JJ
cord-018265-twp33bb6	29	8	comprehensive	comprehensive	JJ
cord-018265-twp33bb6	29	9	studies	study	NNS
cord-018265-twp33bb6	29	10	on	on	IN
cord-018265-twp33bb6	29	11	the	the	DT
cord-018265-twp33bb6	29	12	specific	specific	JJ
cord-018265-twp33bb6	29	13	aetiology	aetiology	NN
cord-018265-twp33bb6	29	14	of	of	IN
cord-018265-twp33bb6	29	15	pneumonia	pneumonia	NN
cord-018265-twp33bb6	29	16	[	[	-LRB-
cord-018265-twp33bb6	29	17	2	2	CD
cord-018265-twp33bb6	29	18	]	]	-RRB-
cord-018265-twp33bb6	29	19	due	due	IN
cord-018265-twp33bb6	29	20	to	to	IN
cord-018265-twp33bb6	29	21	(	(	-LRB-
cord-018265-twp33bb6	29	22	i	i	NN
cord-018265-twp33bb6	29	23	)	)	-RRB-
cord-018265-twp33bb6	29	24	overlaps	overlap	VBZ
cord-018265-twp33bb6	29	25	in	in	IN
cord-018265-twp33bb6	29	26	the	the	DT
cord-018265-twp33bb6	29	27	clinical	clinical	JJ
cord-018265-twp33bb6	29	28	manifestations	manifestation	NNS
cord-018265-twp33bb6	29	29	of	of	IN
cord-018265-twp33bb6	29	30	the	the	DT
cord-018265-twp33bb6	29	31	different	different	JJ
cord-018265-twp33bb6	29	32	syndromes	syndrome	NNS
cord-018265-twp33bb6	29	33	,	,	,
cord-018265-twp33bb6	29	34	(	(	-LRB-
cord-018265-twp33bb6	29	35	ii	ii	NN
cord-018265-twp33bb6	29	36	)	)	-RRB-
cord-018265-twp33bb6	29	37	difficulties	difficulty	NNS
cord-018265-twp33bb6	29	38	in	in	IN
cord-018265-twp33bb6	29	39	establishing	establish	VBG
cord-018265-twp33bb6	29	40	the	the	DT
cord-018265-twp33bb6	29	41	precise	precise	JJ
cord-018265-twp33bb6	29	42	aetiology	aetiology	NN
cord-018265-twp33bb6	29	43	,	,	,
cord-018265-twp33bb6	29	44	and	and	CC
cord-018265-twp33bb6	29	45	(	(	-LRB-
cord-018265-twp33bb6	29	46	iii	iii	NN
cord-018265-twp33bb6	29	47	)	)	-RRB-
cord-018265-twp33bb6	29	48	frequent	frequent	JJ
cord-018265-twp33bb6	29	49	occurrence	occurrence	NN
cord-018265-twp33bb6	29	50	of	of	IN
cord-018265-twp33bb6	29	51	co	co	NNS
cord-018265-twp33bb6	29	52	-	-	NNS
cord-018265-twp33bb6	29	53	infections	infection	NNS
cord-018265-twp33bb6	29	54	.	.	.
cord-018265-twp33bb6	30	1	However	however	RB
cord-018265-twp33bb6	30	2	,	,	,
cord-018265-twp33bb6	30	3	Streptococcus	streptococcus	NN
cord-018265-twp33bb6	30	4	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	30	5	,	,	,
cord-018265-twp33bb6	30	6	Haemophilus	haemophilus	JJ
cord-018265-twp33bb6	30	7	influenzae	influenzae	NN
cord-018265-twp33bb6	30	8	,	,	,
cord-018265-twp33bb6	30	9	respiratory	respiratory	JJ
cord-018265-twp33bb6	30	10	syncytial	syncytial	JJ
cord-018265-twp33bb6	30	11	virus	virus	NN
cord-018265-twp33bb6	30	12	(	(	-LRB-
cord-018265-twp33bb6	30	13	RSV	RSV	NNP
cord-018265-twp33bb6	30	14	)	)	-RRB-
cord-018265-twp33bb6	30	15	,	,	,
cord-018265-twp33bb6	30	16	and	and	CC
cord-018265-twp33bb6	30	17	parainfluenza	parainfluenza	NNP
cord-018265-twp33bb6	30	18	virus	virus	NNP
cord-018265-twp33bb6	30	19	type	type	NNP
cord-018265-twp33bb6	30	20	3	3	CD
cord-018265-twp33bb6	30	21	(	(	-LRB-
cord-018265-twp33bb6	30	22	PIV-3	PIV-3	NNP
cord-018265-twp33bb6	30	23	)	)	-RRB-
cord-018265-twp33bb6	30	24	have	have	VBP
cord-018265-twp33bb6	30	25	been	be	VBN
cord-018265-twp33bb6	30	26	identified	identify	VBN
cord-018265-twp33bb6	30	27	as	as	IN
cord-018265-twp33bb6	30	28	the	the	DT
cord-018265-twp33bb6	30	29	main	main	JJ
cord-018265-twp33bb6	30	30	agents	agent	NNS
cord-018265-twp33bb6	30	31	responsible	responsible	JJ
cord-018265-twp33bb6	30	32	for	for	IN
cord-018265-twp33bb6	30	33	acute	acute	JJ
cord-018265-twp33bb6	30	34	respiratory	respiratory	JJ
cord-018265-twp33bb6	30	35	infections	infection	NNS
cord-018265-twp33bb6	30	36	in	in	IN
cord-018265-twp33bb6	30	37	children	child	NNS
cord-018265-twp33bb6	30	38	,	,	,
cord-018265-twp33bb6	30	39	whereas	whereas	IN
cord-018265-twp33bb6	30	40	influenza	influenza	NN
cord-018265-twp33bb6	30	41	virus	virus	NN
cord-018265-twp33bb6	30	42	related	relate	VBN
cord-018265-twp33bb6	30	43	pneumonia	pneumonia	NN
cord-018265-twp33bb6	30	44	is	be	VBZ
cord-018265-twp33bb6	30	45	the	the	DT
cord-018265-twp33bb6	30	46	leading	leading	JJ
cord-018265-twp33bb6	30	47	cause	cause	NN
cord-018265-twp33bb6	30	48	of	of	IN
cord-018265-twp33bb6	30	49	disease	disease	NN
cord-018265-twp33bb6	30	50	-	-	HYPH
cord-018265-twp33bb6	30	51	related	relate	VBN
cord-018265-twp33bb6	30	52	deaths	death	NNS
cord-018265-twp33bb6	30	53	in	in	IN
cord-018265-twp33bb6	30	54	the	the	DT
cord-018265-twp33bb6	30	55	elderly	elderly	JJ
cord-018265-twp33bb6	30	56	.	.	.
cord-018265-twp33bb6	31	1	In	in	IN
cord-018265-twp33bb6	31	2	addition	addition	NN
cord-018265-twp33bb6	31	3	,	,	,
cord-018265-twp33bb6	31	4	the	the	DT
cord-018265-twp33bb6	31	5	availability	availability	NN
cord-018265-twp33bb6	31	6	of	of	IN
cord-018265-twp33bb6	31	7	new	new	JJ
cord-018265-twp33bb6	31	8	and	and	CC
cord-018265-twp33bb6	31	9	more	more	RBR
cord-018265-twp33bb6	31	10	sensitive	sensitive	JJ
cord-018265-twp33bb6	31	11	diagnostic	diagnostic	JJ
cord-018265-twp33bb6	31	12	tests	test	NNS
cord-018265-twp33bb6	31	13	have	have	VBP
cord-018265-twp33bb6	31	14	contributed	contribute	VBN
cord-018265-twp33bb6	31	15	to	to	IN
cord-018265-twp33bb6	31	16	the	the	DT
cord-018265-twp33bb6	31	17	identification	identification	NN
cord-018265-twp33bb6	31	18	of	of	IN
cord-018265-twp33bb6	31	19	hitherto	hitherto	VBN
cord-018265-twp33bb6	31	20	unknown	unknown	JJ
cord-018265-twp33bb6	31	21	lower	low	JJR
cord-018265-twp33bb6	31	22	respiratory	respiratory	JJ
cord-018265-twp33bb6	31	23	pathogens	pathogen	NNS
cord-018265-twp33bb6	31	24	,	,	,
cord-018265-twp33bb6	31	25	such	such	JJ
cord-018265-twp33bb6	31	26	as	as	IN
cord-018265-twp33bb6	31	27	the	the	DT
cord-018265-twp33bb6	31	28	human	human	JJ
cord-018265-twp33bb6	31	29	metapneumonovirus	metapneumonovirus	NNP
cord-018265-twp33bb6	31	30	(	(	-LRB-
cord-018265-twp33bb6	31	31	hMPV	hmpv	NN
cord-018265-twp33bb6	31	32	)	)	-RRB-
cord-018265-twp33bb6	31	33	and	and	CC
cord-018265-twp33bb6	31	34	novel	novel	NN
cord-018265-twp33bb6	31	35	coronaviruses	coronaviruse	NNS
cord-018265-twp33bb6	31	36	causing	cause	VBG
cord-018265-twp33bb6	31	37	the	the	DT
cord-018265-twp33bb6	31	38	severe	severe	JJ
cord-018265-twp33bb6	31	39	acute	acute	JJ
cord-018265-twp33bb6	31	40	respiratory	respiratory	JJ
cord-018265-twp33bb6	31	41	syndrome	syndrome	NN
cord-018265-twp33bb6	31	42	(	(	-LRB-
cord-018265-twp33bb6	31	43	SARS	SARS	NNP
cord-018265-twp33bb6	31	44	)	)	-RRB-
cord-018265-twp33bb6	31	45	.	.	.
cord-018265-twp33bb6	32	1	Significant	significant	JJ
cord-018265-twp33bb6	32	2	efforts	effort	NNS
cord-018265-twp33bb6	32	3	have	have	VBP
cord-018265-twp33bb6	32	4	been	be	VBN
cord-018265-twp33bb6	32	5	invested	invest	VBN
cord-018265-twp33bb6	32	6	in	in	IN
cord-018265-twp33bb6	32	7	the	the	DT
cord-018265-twp33bb6	32	8	last	last	JJ
cord-018265-twp33bb6	32	9	two	two	CD
cord-018265-twp33bb6	32	10	decades	decade	NNS
cord-018265-twp33bb6	32	11	to	to	TO
cord-018265-twp33bb6	32	12	develop	develop	VB
cord-018265-twp33bb6	32	13	new	new	JJ
cord-018265-twp33bb6	32	14	diagnostic	diagnostic	JJ
cord-018265-twp33bb6	32	15	tools	tool	NNS
cord-018265-twp33bb6	32	16	,	,	,
cord-018265-twp33bb6	32	17	to	to	TO
cord-018265-twp33bb6	32	18	elucidate	elucidate	VB
cord-018265-twp33bb6	32	19	the	the	DT
cord-018265-twp33bb6	32	20	molecular	molecular	JJ
cord-018265-twp33bb6	32	21	mechanisms	mechanism	NNS
cord-018265-twp33bb6	32	22	of	of	IN
cord-018265-twp33bb6	32	23	microbial	microbial	JJ
cord-018265-twp33bb6	32	24	pathogenesis	pathogenesis	NN
cord-018265-twp33bb6	32	25	and	and	CC
cord-018265-twp33bb6	32	26	to	to	TO
cord-018265-twp33bb6	32	27	understand	understand	VB
cord-018265-twp33bb6	32	28	host	host	NN
cord-018265-twp33bb6	32	29	clearance	clearance	NN
cord-018265-twp33bb6	32	30	mechanisms	mechanism	NNS
cord-018265-twp33bb6	32	31	.	.	.
cord-018265-twp33bb6	33	1	This	this	DT
cord-018265-twp33bb6	33	2	resulted	result	VBD
cord-018265-twp33bb6	33	3	in	in	IN
cord-018265-twp33bb6	33	4	an	an	DT
cord-018265-twp33bb6	33	5	improved	improved	JJ
cord-018265-twp33bb6	33	6	knowledge	knowledge	NN
cord-018265-twp33bb6	33	7	on	on	IN
cord-018265-twp33bb6	33	8	host	host	NN
cord-018265-twp33bb6	33	9	responses	response	NNS
cord-018265-twp33bb6	33	10	to	to	IN
cord-018265-twp33bb6	33	11	infection	infection	NN
cord-018265-twp33bb6	33	12	and	and	CC
cord-018265-twp33bb6	33	13	immuno	immuno	JJ
cord-018265-twp33bb6	33	14	-	-	HYPH
cord-018265-twp33bb6	33	15	pathogenesis	pathogenesis	NN
cord-018265-twp33bb6	33	16	,	,	,
cord-018265-twp33bb6	33	17	which	which	WDT
cord-018265-twp33bb6	33	18	in	in	IN
cord-018265-twp33bb6	33	19	turn	turn	NN
cord-018265-twp33bb6	33	20	have	have	VBP
cord-018265-twp33bb6	33	21	facilitated	facilitate	VBN
cord-018265-twp33bb6	33	22	the	the	DT
cord-018265-twp33bb6	33	23	establishment	establishment	NN
cord-018265-twp33bb6	33	24	of	of	IN
cord-018265-twp33bb6	33	25	new	new	JJ
cord-018265-twp33bb6	33	26	prophylactic	prophylactic	JJ
cord-018265-twp33bb6	33	27	and	and	CC
cord-018265-twp33bb6	33	28	therapeutic	therapeutic	JJ
cord-018265-twp33bb6	33	29	interventions	intervention	NNS
cord-018265-twp33bb6	33	30	.	.	.
cord-018265-twp33bb6	34	1	However	however	RB
cord-018265-twp33bb6	34	2	,	,	,
cord-018265-twp33bb6	34	3	despite	despite	IN
cord-018265-twp33bb6	34	4	our	-PRON-	PRP$
cord-018265-twp33bb6	34	5	accomplishments	accomplishment	NNS
cord-018265-twp33bb6	34	6	in	in	IN
cord-018265-twp33bb6	34	7	vaccine	vaccine	NN
cord-018265-twp33bb6	34	8	development	development	NN
cord-018265-twp33bb6	34	9	,	,	,
cord-018265-twp33bb6	34	10	there	there	EX
cord-018265-twp33bb6	34	11	are	be	VBP
cord-018265-twp33bb6	34	12	many	many	JJ
cord-018265-twp33bb6	34	13	pathogens	pathogen	NNS
cord-018265-twp33bb6	34	14	for	for	IN
cord-018265-twp33bb6	34	15	which	which	WDT
cord-018265-twp33bb6	34	16	vaccines	vaccine	NNS
cord-018265-twp33bb6	34	17	or	or	CC
cord-018265-twp33bb6	34	18	adequate	adequate	JJ
cord-018265-twp33bb6	34	19	therapies	therapy	NNS
cord-018265-twp33bb6	34	20	are	be	VBP
cord-018265-twp33bb6	34	21	not	not	RB
cord-018265-twp33bb6	34	22	available	available	JJ
cord-018265-twp33bb6	34	23	or	or	CC
cord-018265-twp33bb6	34	24	the	the	DT
cord-018265-twp33bb6	34	25	existent	existent	JJ
cord-018265-twp33bb6	34	26	ones	one	NNS
cord-018265-twp33bb6	34	27	are	be	VBP
cord-018265-twp33bb6	34	28	suboptimal	suboptimal	JJ
cord-018265-twp33bb6	34	29	.	.	.
cord-018265-twp33bb6	35	1	The	the	DT
cord-018265-twp33bb6	35	2	main	main	JJ
cord-018265-twp33bb6	35	3	approach	approach	NN
cord-018265-twp33bb6	35	4	applied	apply	VBD
cord-018265-twp33bb6	35	5	for	for	IN
cord-018265-twp33bb6	35	6	vaccine	vaccine	NN
cord-018265-twp33bb6	35	7	development	development	NN
cord-018265-twp33bb6	35	8	has	have	VBZ
cord-018265-twp33bb6	35	9	radically	radically	RB
cord-018265-twp33bb6	35	10	changed	change	VBN
cord-018265-twp33bb6	35	11	in	in	IN
cord-018265-twp33bb6	35	12	recent	recent	JJ
cord-018265-twp33bb6	35	13	years	year	NNS
cord-018265-twp33bb6	35	14	.	.	.
cord-018265-twp33bb6	36	1	Whole	whole	JJ
cord-018265-twp33bb6	36	2	cell	cell	NN
cord-018265-twp33bb6	36	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	36	4	are	be	VBP
cord-018265-twp33bb6	36	5	systematically	systematically	RB
cord-018265-twp33bb6	36	6	being	be	VBG
cord-018265-twp33bb6	36	7	replaced	replace	VBN
cord-018265-twp33bb6	36	8	by	by	IN
cord-018265-twp33bb6	36	9	subunit	subunit	NN
cord-018265-twp33bb6	36	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	36	11	,	,	,
cord-018265-twp33bb6	36	12	in	in	IN
cord-018265-twp33bb6	36	13	which	which	WDT
cord-018265-twp33bb6	36	14	purified	purify	VBN
cord-018265-twp33bb6	36	15	antigens	antigen	NNS
cord-018265-twp33bb6	36	16	or	or	CC
cord-018265-twp33bb6	36	17	their	-PRON-	PRP$
cord-018265-twp33bb6	36	18	coding	code	VBG
cord-018265-twp33bb6	36	19	genes	gene	NNS
cord-018265-twp33bb6	36	20	are	be	VBP
cord-018265-twp33bb6	36	21	exploited	exploit	VBN
cord-018265-twp33bb6	36	22	in	in	IN
cord-018265-twp33bb6	36	23	combination	combination	NN
cord-018265-twp33bb6	36	24	with	with	IN
cord-018265-twp33bb6	36	25	new	new	JJ
cord-018265-twp33bb6	36	26	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	36	27	and/or	and/or	CC
cord-018265-twp33bb6	36	28	delivery	delivery	NN
cord-018265-twp33bb6	36	29	systems	system	NNS
cord-018265-twp33bb6	36	30	.	.	.
cord-018265-twp33bb6	37	1	As	as	IN
cord-018265-twp33bb6	37	2	a	a	DT
cord-018265-twp33bb6	37	3	result	result	NN
cord-018265-twp33bb6	37	4	,	,	,
cord-018265-twp33bb6	37	5	many	many	JJ
cord-018265-twp33bb6	37	6	of	of	IN
cord-018265-twp33bb6	37	7	the	the	DT
cord-018265-twp33bb6	37	8	vaccines	vaccine	NNS
cord-018265-twp33bb6	37	9	under	under	IN
cord-018265-twp33bb6	37	10	development	development	NN
cord-018265-twp33bb6	37	11	will	will	MD
cord-018265-twp33bb6	37	12	exhibit	exhibit	VB
cord-018265-twp33bb6	37	13	consistently	consistently	RB
cord-018265-twp33bb6	37	14	improved	improve	VBN
cord-018265-twp33bb6	37	15	stability	stability	NN
cord-018265-twp33bb6	37	16	,	,	,
cord-018265-twp33bb6	37	17	safety	safety	NN
cord-018265-twp33bb6	37	18	and	and	CC
cord-018265-twp33bb6	37	19	efficacy	efficacy	NN
cord-018265-twp33bb6	37	20	profiles	profile	NNS
cord-018265-twp33bb6	37	21	.	.	.
cord-018265-twp33bb6	38	1	They	-PRON-	PRP
cord-018265-twp33bb6	38	2	will	will	MD
cord-018265-twp33bb6	38	3	also	also	RB
cord-018265-twp33bb6	38	4	be	be	VB
cord-018265-twp33bb6	38	5	amenable	amenable	JJ
cord-018265-twp33bb6	38	6	for	for	IN
cord-018265-twp33bb6	38	7	mucosal	mucosal	JJ
cord-018265-twp33bb6	38	8	administration	administration	NN
cord-018265-twp33bb6	38	9	,	,	,
cord-018265-twp33bb6	38	10	thereby	thereby	RB
cord-018265-twp33bb6	38	11	mimicking	mimic	VBG
cord-018265-twp33bb6	38	12	natural	natural	JJ
cord-018265-twp33bb6	38	13	infections	infection	NNS
cord-018265-twp33bb6	38	14	.	.	.
cord-018265-twp33bb6	39	1	Influenza	Influenza	NNP
cord-018265-twp33bb6	39	2	A	a	DT
cord-018265-twp33bb6	39	3	viruses	virus	NNS
cord-018265-twp33bb6	39	4	are	be	VBP
cord-018265-twp33bb6	39	5	the	the	DT
cord-018265-twp33bb6	39	6	most	most	RBS
cord-018265-twp33bb6	39	7	commonly	commonly	RB
cord-018265-twp33bb6	39	8	responsible	responsible	JJ
cord-018265-twp33bb6	39	9	for	for	IN
cord-018265-twp33bb6	39	10	severe	severe	JJ
cord-018265-twp33bb6	39	11	respiratory	respiratory	JJ
cord-018265-twp33bb6	39	12	illness	illness	NN
cord-018265-twp33bb6	39	13	in	in	IN
cord-018265-twp33bb6	39	14	humans	human	NNS
cord-018265-twp33bb6	39	15	,	,	,
cord-018265-twp33bb6	39	16	followed	follow	VBN
cord-018265-twp33bb6	39	17	by	by	IN
cord-018265-twp33bb6	40	1	influenza	influenza	NN
cord-018265-twp33bb6	40	2	B.	B.	NNP
cord-018265-twp33bb6	40	3	The	the	DT
cord-018265-twp33bb6	40	4	population	population	NN
cord-018265-twp33bb6	40	5	's	's	POS
cord-018265-twp33bb6	40	6	susceptibly	susceptibly	NN
cord-018265-twp33bb6	40	7	to	to	IN
cord-018265-twp33bb6	40	8	infection	infection	NN
cord-018265-twp33bb6	40	9	is	be	VBZ
cord-018265-twp33bb6	40	10	renewed	renew	VBN
cord-018265-twp33bb6	40	11	annually	annually	RB
cord-018265-twp33bb6	40	12	,	,	,
cord-018265-twp33bb6	40	13	because	because	IN
cord-018265-twp33bb6	40	14	of	of	IN
cord-018265-twp33bb6	40	15	the	the	DT
cord-018265-twp33bb6	40	16	rapid	rapid	JJ
cord-018265-twp33bb6	40	17	antigenic	antigenic	JJ
cord-018265-twp33bb6	40	18	variation	variation	NN
cord-018265-twp33bb6	40	19	of	of	IN
cord-018265-twp33bb6	40	20	this	this	DT
cord-018265-twp33bb6	40	21	virus	virus	NN
cord-018265-twp33bb6	40	22	.	.	.
cord-018265-twp33bb6	41	1	The	the	DT
cord-018265-twp33bb6	41	2	antigenic	antigenic	JJ
cord-018265-twp33bb6	41	3	variation	variation	NN
cord-018265-twp33bb6	41	4	is	be	VBZ
cord-018265-twp33bb6	41	5	due	due	JJ
cord-018265-twp33bb6	41	6	to	to	IN
cord-018265-twp33bb6	41	7	the	the	DT
cord-018265-twp33bb6	41	8	accumulation	accumulation	NN
cord-018265-twp33bb6	41	9	of	of	IN
cord-018265-twp33bb6	41	10	point	point	NN
cord-018265-twp33bb6	41	11	mutations	mutation	NNS
cord-018265-twp33bb6	41	12	in	in	IN
cord-018265-twp33bb6	41	13	the	the	DT
cord-018265-twp33bb6	41	14	two	two	CD
cord-018265-twp33bb6	41	15	major	major	JJ
cord-018265-twp33bb6	41	16	surface	surface	NN
cord-018265-twp33bb6	41	17	glycoproteins	glycoprotein	NNS
cord-018265-twp33bb6	41	18	of	of	IN
cord-018265-twp33bb6	41	19	the	the	DT
cord-018265-twp33bb6	41	20	virus	virus	NN
cord-018265-twp33bb6	41	21	,	,	,
cord-018265-twp33bb6	41	22	haemagglutinin	haemagglutinin	NNP
cord-018265-twp33bb6	41	23	(	(	-LRB-
cord-018265-twp33bb6	41	24	HA	HA	NNP
cord-018265-twp33bb6	41	25	)	)	-RRB-
cord-018265-twp33bb6	41	26	and	and	CC
cord-018265-twp33bb6	41	27	neuraminidase	neuraminidase	NN
cord-018265-twp33bb6	41	28	(	(	-LRB-
cord-018265-twp33bb6	41	29	NA	NA	NNP
cord-018265-twp33bb6	41	30	)	)	-RRB-
cord-018265-twp33bb6	41	31	.	.	.
cord-018265-twp33bb6	42	1	This	this	DT
cord-018265-twp33bb6	42	2	can	can	MD
cord-018265-twp33bb6	42	3	lead	lead	VB
cord-018265-twp33bb6	42	4	to	to	IN
cord-018265-twp33bb6	42	5	an	an	DT
cord-018265-twp33bb6	42	6	antigenic	antigenic	JJ
cord-018265-twp33bb6	42	7	drift	drift	NN
cord-018265-twp33bb6	42	8	of	of	IN
cord-018265-twp33bb6	42	9	the	the	DT
cord-018265-twp33bb6	42	10	virus	virus	NN
cord-018265-twp33bb6	42	11	,	,	,
cord-018265-twp33bb6	42	12	which	which	WDT
cord-018265-twp33bb6	42	13	often	often	RB
cord-018265-twp33bb6	42	14	leaves	leave	VBZ
cord-018265-twp33bb6	42	15	current	current	JJ
cord-018265-twp33bb6	42	16	influenza	influenza	NN
cord-018265-twp33bb6	42	17	vaccines	vaccine	NNS
cord-018265-twp33bb6	42	18	outdated	outdate	VBN
cord-018265-twp33bb6	42	19	and	and	CC
cord-018265-twp33bb6	42	20	ineffective	ineffective	JJ
cord-018265-twp33bb6	42	21	.	.	.
cord-018265-twp33bb6	43	1	Antigenic	antigenic	JJ
cord-018265-twp33bb6	43	2	shift	shift	NN
cord-018265-twp33bb6	43	3	can	can	MD
cord-018265-twp33bb6	43	4	also	also	RB
cord-018265-twp33bb6	43	5	occur	occur	VB
cord-018265-twp33bb6	43	6	due	due	JJ
cord-018265-twp33bb6	43	7	to	to	IN
cord-018265-twp33bb6	43	8	the	the	DT
cord-018265-twp33bb6	43	9	segmented	segmented	JJ
cord-018265-twp33bb6	43	10	nature	nature	NN
cord-018265-twp33bb6	43	11	of	of	IN
cord-018265-twp33bb6	43	12	the	the	DT
cord-018265-twp33bb6	43	13	viral	viral	JJ
cord-018265-twp33bb6	43	14	genome	genome	NN
cord-018265-twp33bb6	43	15	that	that	WDT
cord-018265-twp33bb6	43	16	favours	favour	VBZ
cord-018265-twp33bb6	43	17	the	the	DT
cord-018265-twp33bb6	43	18	emergence	emergence	NN
cord-018265-twp33bb6	43	19	of	of	IN
cord-018265-twp33bb6	43	20	re	re	NN
cord-018265-twp33bb6	43	21	-	-	JJ
cord-018265-twp33bb6	43	22	assorted	assorted	JJ
cord-018265-twp33bb6	43	23	strains	strain	NNS
cord-018265-twp33bb6	43	24	,	,	,
cord-018265-twp33bb6	43	25	in	in	IN
cord-018265-twp33bb6	43	26	which	which	WDT
cord-018265-twp33bb6	43	27	an	an	DT
cord-018265-twp33bb6	43	28	entire	entire	JJ
cord-018265-twp33bb6	43	29	glycoprotein	glycoprotein	NN
cord-018265-twp33bb6	43	30	can	can	MD
cord-018265-twp33bb6	43	31	be	be	VB
cord-018265-twp33bb6	43	32	acquired	acquire	VBN
cord-018265-twp33bb6	43	33	from	from	IN
cord-018265-twp33bb6	43	34	a	a	DT
cord-018265-twp33bb6	43	35	different	different	JJ
cord-018265-twp33bb6	43	36	animal	animal	NN
cord-018265-twp33bb6	43	37	influenza	influenza	NN
cord-018265-twp33bb6	43	38	virus	virus	NN
cord-018265-twp33bb6	43	39	.	.	.
cord-018265-twp33bb6	44	1	Both	both	DT
cord-018265-twp33bb6	44	2	types	type	NNS
cord-018265-twp33bb6	44	3	of	of	IN
cord-018265-twp33bb6	44	4	variation	variation	NN
cord-018265-twp33bb6	44	5	represent	represent	VBP
cord-018265-twp33bb6	44	6	a	a	DT
cord-018265-twp33bb6	44	7	critical	critical	JJ
cord-018265-twp33bb6	44	8	bottleneck	bottleneck	NN
cord-018265-twp33bb6	44	9	for	for	IN
cord-018265-twp33bb6	44	10	the	the	DT
cord-018265-twp33bb6	44	11	establishment	establishment	NN
cord-018265-twp33bb6	44	12	of	of	IN
cord-018265-twp33bb6	44	13	a	a	DT
cord-018265-twp33bb6	44	14	robust	robust	JJ
cord-018265-twp33bb6	44	15	vaccination	vaccination	NN
cord-018265-twp33bb6	44	16	strategy	strategy	NN
cord-018265-twp33bb6	44	17	against	against	IN
cord-018265-twp33bb6	44	18	influenza	influenza	NN
cord-018265-twp33bb6	44	19	.	.	.
cord-018265-twp33bb6	45	1	In	in	IN
cord-018265-twp33bb6	45	2	fact	fact	NN
cord-018265-twp33bb6	45	3	,	,	,
cord-018265-twp33bb6	45	4	when	when	WRB
cord-018265-twp33bb6	45	5	an	an	DT
cord-018265-twp33bb6	45	6	influenza	influenza	NN
cord-018265-twp33bb6	45	7	virus	virus	NN
cord-018265-twp33bb6	45	8	with	with	IN
cord-018265-twp33bb6	45	9	the	the	DT
cord-018265-twp33bb6	45	10	capacity	capacity	NN
cord-018265-twp33bb6	45	11	to	to	TO
cord-018265-twp33bb6	45	12	spread	spread	VB
cord-018265-twp33bb6	45	13	from	from	IN
cord-018265-twp33bb6	45	14	person	person	NN
cord-018265-twp33bb6	45	15	-	-	HYPH
cord-018265-twp33bb6	45	16	to	to	IN
cord-018265-twp33bb6	45	17	-	-	HYPH
cord-018265-twp33bb6	45	18	person	person	NN
cord-018265-twp33bb6	45	19	and	and	CC
cord-018265-twp33bb6	45	20	a	a	DT
cord-018265-twp33bb6	45	21	complete	complete	JJ
cord-018265-twp33bb6	45	22	new	new	JJ
cord-018265-twp33bb6	45	23	glycoprotein	glycoprotein	NN
cord-018265-twp33bb6	45	24	subtype	subtype	NN
cord-018265-twp33bb6	45	25	suddenly	suddenly	RB
cord-018265-twp33bb6	45	26	emerges	emerge	VBZ
cord-018265-twp33bb6	45	27	,	,	,
cord-018265-twp33bb6	45	28	a	a	DT
cord-018265-twp33bb6	45	29	worldwide	worldwide	JJ
cord-018265-twp33bb6	45	30	pandemic	pandemic	JJ
cord-018265-twp33bb6	45	31	outbreak	outbreak	NN
cord-018265-twp33bb6	45	32	can	can	MD
cord-018265-twp33bb6	45	33	result	result	VB
cord-018265-twp33bb6	45	34	[	[	-LRB-
cord-018265-twp33bb6	45	35	3	3	CD
cord-018265-twp33bb6	45	36	]	]	-RRB-
cord-018265-twp33bb6	45	37	.	.	.
cord-018265-twp33bb6	46	1	The	the	DT
cord-018265-twp33bb6	46	2	earliest	early	JJS
cord-018265-twp33bb6	46	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	46	4	against	against	IN
cord-018265-twp33bb6	46	5	influenza	influenza	NN
cord-018265-twp33bb6	46	6	were	be	VBD
cord-018265-twp33bb6	46	7	whole	whole	JJ
cord-018265-twp33bb6	46	8	cell	cell	NN
cord-018265-twp33bb6	46	9	vaccines	vaccine	NNS
cord-018265-twp33bb6	46	10	obtained	obtain	VBN
cord-018265-twp33bb6	46	11	in	in	IN
cord-018265-twp33bb6	46	12	the	the	DT
cord-018265-twp33bb6	46	13	1940s	1940	NNS
cord-018265-twp33bb6	46	14	by	by	IN
cord-018265-twp33bb6	46	15	inactivating	inactivate	VBG
cord-018265-twp33bb6	46	16	viruses	virus	NNS
cord-018265-twp33bb6	46	17	grown	grow	VBN
cord-018265-twp33bb6	46	18	in	in	IN
cord-018265-twp33bb6	46	19	the	the	DT
cord-018265-twp33bb6	46	20	allantoic	allantoic	NNP
cord-018265-twp33bb6	46	21	cavity	cavity	NN
cord-018265-twp33bb6	46	22	of	of	IN
cord-018265-twp33bb6	46	23	embryonated	embryonate	VBN
cord-018265-twp33bb6	46	24	chicken	chicken	NN
cord-018265-twp33bb6	46	25	eggs	egg	NNS
cord-018265-twp33bb6	46	26	with	with	IN
cord-018265-twp33bb6	46	27	formalin	formalin	NN
cord-018265-twp33bb6	46	28	.	.	.
cord-018265-twp33bb6	47	1	While	while	IN
cord-018265-twp33bb6	47	2	contemporary	contemporary	JJ
cord-018265-twp33bb6	47	3	inactivated	inactivate	VBN
cord-018265-twp33bb6	47	4	influenza	influenza	NN
cord-018265-twp33bb6	47	5	vaccines	vaccine	NNS
cord-018265-twp33bb6	47	6	are	be	VBP
cord-018265-twp33bb6	47	7	still	still	RB
cord-018265-twp33bb6	47	8	produced	produce	VBN
cord-018265-twp33bb6	47	9	in	in	IN
cord-018265-twp33bb6	47	10	embryonated	embryonate	VBN
cord-018265-twp33bb6	47	11	eggs	egg	NNS
cord-018265-twp33bb6	47	12	,	,	,
cord-018265-twp33bb6	47	13	improvements	improvement	NNS
cord-018265-twp33bb6	47	14	in	in	IN
cord-018265-twp33bb6	47	15	manufacturing	manufacturing	NN
cord-018265-twp33bb6	47	16	have	have	VBP
cord-018265-twp33bb6	47	17	resulted	result	VBN
cord-018265-twp33bb6	47	18	in	in	IN
cord-018265-twp33bb6	47	19	a	a	DT
cord-018265-twp33bb6	47	20	highly	highly	RB
cord-018265-twp33bb6	47	21	purified	purify	VBN
cord-018265-twp33bb6	47	22	and	and	CC
cord-018265-twp33bb6	47	23	less	less	RBR
cord-018265-twp33bb6	47	24	-	-	HYPH
cord-018265-twp33bb6	47	25	reactogenic	reactogenic	JJ
cord-018265-twp33bb6	47	26	detergentsplit	detergentsplit	JJ
cord-018265-twp33bb6	47	27	product	product	NN
cord-018265-twp33bb6	47	28	.	.	.
cord-018265-twp33bb6	48	1	Three	three	CD
cord-018265-twp33bb6	48	2	viral	viral	JJ
cord-018265-twp33bb6	48	3	strains	strain	NNS
cord-018265-twp33bb6	48	4	are	be	VBP
cord-018265-twp33bb6	48	5	selected	select	VBN
cord-018265-twp33bb6	48	6	on	on	IN
cord-018265-twp33bb6	48	7	the	the	DT
cord-018265-twp33bb6	48	8	basis	basis	NN
cord-018265-twp33bb6	48	9	of	of	IN
cord-018265-twp33bb6	48	10	the	the	DT
cord-018265-twp33bb6	48	11	previous	previous	JJ
cord-018265-twp33bb6	48	12	year	year	NN
cord-018265-twp33bb6	48	13	's	's	POS
cord-018265-twp33bb6	48	14	surveillance	surveillance	NN
cord-018265-twp33bb6	48	15	data	datum	NNS
cord-018265-twp33bb6	48	16	on	on	IN
cord-018265-twp33bb6	48	17	the	the	DT
cord-018265-twp33bb6	48	18	most	most	RBS
cord-018265-twp33bb6	48	19	prevalent	prevalent	JJ
cord-018265-twp33bb6	48	20	subtypes	subtype	NNS
cord-018265-twp33bb6	48	21	,	,	,
cord-018265-twp33bb6	48	22	therefore	therefore	RB
cord-018265-twp33bb6	48	23	,	,	,
cord-018265-twp33bb6	48	24	vaccine	vaccine	NN
cord-018265-twp33bb6	48	25	composition	composition	NN
cord-018265-twp33bb6	48	26	may	may	MD
cord-018265-twp33bb6	48	27	vary	vary	VB
cord-018265-twp33bb6	48	28	from	from	IN
cord-018265-twp33bb6	48	29	year	year	NN
cord-018265-twp33bb6	48	30	-	-	HYPH
cord-018265-twp33bb6	48	31	to	to	IN
cord-018265-twp33bb6	48	32	-	-	HYPH
cord-018265-twp33bb6	48	33	year	year	NN
cord-018265-twp33bb6	48	34	.	.	.
cord-018265-twp33bb6	49	1	Vaccination	vaccination	NN
cord-018265-twp33bb6	49	2	has	have	VBZ
cord-018265-twp33bb6	49	3	a	a	DT
cord-018265-twp33bb6	49	4	high	high	JJ
cord-018265-twp33bb6	49	5	benefit	benefit	NN
cord-018265-twp33bb6	49	6	:	:	:
cord-018265-twp33bb6	49	7	cost	cost	NN
cord-018265-twp33bb6	49	8	ratio	ratio	NN
cord-018265-twp33bb6	49	9	,	,	,
cord-018265-twp33bb6	49	10	since	since	IN
cord-018265-twp33bb6	49	11	influenza	influenza	NN
cord-018265-twp33bb6	49	12	-	-	HYPH
cord-018265-twp33bb6	49	13	related	relate	VBN
cord-018265-twp33bb6	49	14	illness	illness	NN
cord-018265-twp33bb6	49	15	(	(	-LRB-
cord-018265-twp33bb6	49	16	e.g.	e.g.	RB
cord-018265-twp33bb6	49	17	,	,	,
cord-018265-twp33bb6	49	18	hospitalizations	hospitalization	NNS
cord-018265-twp33bb6	49	19	and	and	CC
cord-018265-twp33bb6	49	20	deaths	death	NNS
cord-018265-twp33bb6	49	21	)	)	-RRB-
cord-018265-twp33bb6	49	22	are	be	VBP
cord-018265-twp33bb6	49	23	effectively	effectively	RB
cord-018265-twp33bb6	49	24	prevented	prevent	VBN
cord-018265-twp33bb6	49	25	[	[	-LRB-
cord-018265-twp33bb6	49	26	1	1	CD
cord-018265-twp33bb6	49	27	]	]	-RRB-
cord-018265-twp33bb6	49	28	.	.	.
cord-018265-twp33bb6	50	1	The	the	DT
cord-018265-twp33bb6	50	2	world	world	NN
cord-018265-twp33bb6	50	3	's	's	POS
cord-018265-twp33bb6	50	4	total	total	JJ
cord-018265-twp33bb6	50	5	vaccine	vaccine	NN
cord-018265-twp33bb6	50	6	production	production	NN
cord-018265-twp33bb6	50	7	is	be	VBZ
cord-018265-twp33bb6	50	8	approximately	approximately	RB
cord-018265-twp33bb6	50	9	300	300	CD
cord-018265-twp33bb6	50	10	million	million	CD
cord-018265-twp33bb6	50	11	doses	dose	NNS
cord-018265-twp33bb6	50	12	,	,	,
cord-018265-twp33bb6	50	13	with	with	IN
cord-018265-twp33bb6	50	14	a	a	DT
cord-018265-twp33bb6	50	15	maximum	maximum	JJ
cord-018265-twp33bb6	50	16	capacity	capacity	NN
cord-018265-twp33bb6	50	17	of	of	IN
cord-018265-twp33bb6	50	18	900	900	CD
cord-018265-twp33bb6	50	19	million	million	CD
cord-018265-twp33bb6	50	20	doses	dose	NNS
cord-018265-twp33bb6	50	21	.	.	.
cord-018265-twp33bb6	51	1	However	however	RB
cord-018265-twp33bb6	51	2	,	,	,
cord-018265-twp33bb6	51	3	the	the	DT
cord-018265-twp33bb6	51	4	World	World	NNP
cord-018265-twp33bb6	51	5	Health	Health	NNP
cord-018265-twp33bb6	51	6	Organization	Organization	NNP
cord-018265-twp33bb6	51	7	(	(	-LRB-
cord-018265-twp33bb6	51	8	WHO	who	WP
cord-018265-twp33bb6	51	9	)	)	-RRB-
cord-018265-twp33bb6	51	10	estimates	estimate	VBZ
cord-018265-twp33bb6	51	11	that	that	IN
cord-018265-twp33bb6	51	12	there	there	EX
cord-018265-twp33bb6	51	13	are	be	VBP
cord-018265-twp33bb6	51	14	about	about	RB
cord-018265-twp33bb6	51	15	1.2	1.2	CD
cord-018265-twp33bb6	51	16	billion	billion	CD
cord-018265-twp33bb6	51	17	people	people	NNS
cord-018265-twp33bb6	51	18	at	at	IN
cord-018265-twp33bb6	51	19	high	high	JJ
cord-018265-twp33bb6	51	20	risk	risk	NN
cord-018265-twp33bb6	51	21	for	for	IN
cord-018265-twp33bb6	51	22	severe	severe	JJ
cord-018265-twp33bb6	51	23	influenza	influenza	NN
cord-018265-twp33bb6	51	24	outcomes	outcome	NNS
cord-018265-twp33bb6	51	25	(	(	-LRB-
cord-018265-twp33bb6	51	26	e.g.	e.g.	RB
cord-018265-twp33bb6	51	27	,	,	,
cord-018265-twp33bb6	51	28	elderly	elderly	JJ
cord-018265-twp33bb6	51	29	over	over	IN
cord-018265-twp33bb6	51	30	65	65	CD
cord-018265-twp33bb6	51	31	years	year	NNS
cord-018265-twp33bb6	51	32	of	of	IN
cord-018265-twp33bb6	51	33	age	age	NN
cord-018265-twp33bb6	51	34	,	,	,
cord-018265-twp33bb6	51	35	infants	infant	NNS
cord-018265-twp33bb6	51	36	,	,	,
cord-018265-twp33bb6	51	37	health	health	NN
cord-018265-twp33bb6	51	38	care	care	NN
cord-018265-twp33bb6	51	39	workers	worker	NNS
cord-018265-twp33bb6	51	40	,	,	,
cord-018265-twp33bb6	51	41	children	child	NNS
cord-018265-twp33bb6	51	42	and	and	CC
cord-018265-twp33bb6	51	43	adults	adult	NNS
cord-018265-twp33bb6	51	44	with	with	IN
cord-018265-twp33bb6	51	45	underlying	underlying	JJ
cord-018265-twp33bb6	51	46	cardiopulmonary	cardiopulmonary	JJ
cord-018265-twp33bb6	51	47	disease	disease	NN
cord-018265-twp33bb6	51	48	)	)	-RRB-
cord-018265-twp33bb6	51	49	.	.	.
cord-018265-twp33bb6	52	1	Furthermore	furthermore	RB
cord-018265-twp33bb6	52	2	,	,	,
cord-018265-twp33bb6	52	3	the	the	DT
cord-018265-twp33bb6	52	4	global	global	JJ
cord-018265-twp33bb6	52	5	infrastructure	infrastructure	NN
cord-018265-twp33bb6	52	6	would	would	MD
cord-018265-twp33bb6	52	7	not	not	RB
cord-018265-twp33bb6	52	8	be	be	VB
cord-018265-twp33bb6	52	9	able	able	JJ
cord-018265-twp33bb6	52	10	to	to	TO
cord-018265-twp33bb6	52	11	handle	handle	VB
cord-018265-twp33bb6	52	12	the	the	DT
cord-018265-twp33bb6	52	13	timely	timely	JJ
cord-018265-twp33bb6	52	14	manufacturing	manufacturing	NN
cord-018265-twp33bb6	52	15	and	and	CC
cord-018265-twp33bb6	52	16	distribution	distribution	NN
cord-018265-twp33bb6	52	17	of	of	IN
cord-018265-twp33bb6	52	18	a	a	DT
cord-018265-twp33bb6	52	19	vaccine	vaccine	NN
cord-018265-twp33bb6	52	20	for	for	IN
cord-018265-twp33bb6	52	21	a	a	DT
cord-018265-twp33bb6	52	22	pandemic	pandemic	JJ
cord-018265-twp33bb6	52	23	outbreak	outbreak	NN
cord-018265-twp33bb6	52	24	[	[	-LRB-
cord-018265-twp33bb6	52	25	4	4	CD
cord-018265-twp33bb6	52	26	]	]	-RRB-
cord-018265-twp33bb6	52	27	.	.	.
cord-018265-twp33bb6	53	1	One	one	CD
cord-018265-twp33bb6	53	2	alternative	alternative	NN
cord-018265-twp33bb6	53	3	would	would	MD
cord-018265-twp33bb6	53	4	be	be	VB
cord-018265-twp33bb6	53	5	to	to	TO
cord-018265-twp33bb6	53	6	lower	lower	VB
cord-018265-twp33bb6	53	7	the	the	DT
cord-018265-twp33bb6	53	8	quantity	quantity	NN
cord-018265-twp33bb6	53	9	of	of	IN
cord-018265-twp33bb6	53	10	antigen	antigen	NN
cord-018265-twp33bb6	53	11	per	per	IN
cord-018265-twp33bb6	53	12	dose	dose	NN
cord-018265-twp33bb6	53	13	and	and	CC
cord-018265-twp33bb6	53	14	add	add	VB
cord-018265-twp33bb6	53	15	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	53	16	to	to	IN
cord-018265-twp33bb6	53	17	the	the	DT
cord-018265-twp33bb6	53	18	vaccine	vaccine	NN
cord-018265-twp33bb6	53	19	formulation	formulation	NN
cord-018265-twp33bb6	53	20	,	,	,
cord-018265-twp33bb6	53	21	but	but	CC
cord-018265-twp33bb6	53	22	this	this	DT
cord-018265-twp33bb6	53	23	needs	need	VBZ
cord-018265-twp33bb6	53	24	to	to	TO
cord-018265-twp33bb6	53	25	be	be	VB
cord-018265-twp33bb6	53	26	tested	test	VBN
cord-018265-twp33bb6	53	27	in	in	IN
cord-018265-twp33bb6	53	28	clinical	clinical	JJ
cord-018265-twp33bb6	53	29	trials	trial	NNS
cord-018265-twp33bb6	53	30	[	[	-LRB-
cord-018265-twp33bb6	53	31	5	5	CD
cord-018265-twp33bb6	53	32	]	]	-RRB-
cord-018265-twp33bb6	53	33	.	.	.
cord-018265-twp33bb6	54	1	Another	another	DT
cord-018265-twp33bb6	54	2	solution	solution	NN
cord-018265-twp33bb6	54	3	would	would	MD
cord-018265-twp33bb6	54	4	be	be	VB
cord-018265-twp33bb6	54	5	to	to	TO
cord-018265-twp33bb6	54	6	improve	improve	VB
cord-018265-twp33bb6	54	7	current	current	JJ
cord-018265-twp33bb6	54	8	vaccine	vaccine	NN
cord-018265-twp33bb6	54	9	production	production	NN
cord-018265-twp33bb6	54	10	technologies	technology	NNS
cord-018265-twp33bb6	54	11	(	(	-LRB-
cord-018265-twp33bb6	54	12	i.e.	i.e.	FW
cord-018265-twp33bb6	54	13	,	,	,
cord-018265-twp33bb6	54	14	egg	egg	NN
cord-018265-twp33bb6	54	15	-	-	HYPH
cord-018265-twp33bb6	54	16	derived	derive	VBN
cord-018265-twp33bb6	54	17	vaccines	vaccine	NNS
cord-018265-twp33bb6	54	18	)	)	-RRB-
cord-018265-twp33bb6	54	19	.	.	.
cord-018265-twp33bb6	55	1	However	however	RB
cord-018265-twp33bb6	55	2	,	,	,
cord-018265-twp33bb6	55	3	there	there	EX
cord-018265-twp33bb6	55	4	is	be	VBZ
cord-018265-twp33bb6	55	5	the	the	DT
cord-018265-twp33bb6	55	6	limited	limited	JJ
cord-018265-twp33bb6	55	7	number	number	NN
cord-018265-twp33bb6	55	8	of	of	IN
cord-018265-twp33bb6	55	9	egg	egg	NN
cord-018265-twp33bb6	55	10	producers	producer	NNS
cord-018265-twp33bb6	55	11	and	and	CC
cord-018265-twp33bb6	55	12	viral	viral	JJ
cord-018265-twp33bb6	55	13	strains	strain	NNS
cord-018265-twp33bb6	55	14	can	can	MD
cord-018265-twp33bb6	55	15	emerge	emerge	VB
cord-018265-twp33bb6	55	16	,	,	,
cord-018265-twp33bb6	55	17	which	which	WDT
cord-018265-twp33bb6	55	18	could	could	MD
cord-018265-twp33bb6	55	19	not	not	RB
cord-018265-twp33bb6	55	20	be	be	VB
cord-018265-twp33bb6	55	21	easily	easily	RB
cord-018265-twp33bb6	55	22	adapted	adapt	VBN
cord-018265-twp33bb6	55	23	to	to	IN
cord-018265-twp33bb6	55	24	embryonated	embryonate	VBN
cord-018265-twp33bb6	55	25	eggs	egg	NNS
cord-018265-twp33bb6	55	26	.	.	.
cord-018265-twp33bb6	56	1	To	to	TO
cord-018265-twp33bb6	56	2	overcome	overcome	VB
cord-018265-twp33bb6	56	3	these	these	DT
cord-018265-twp33bb6	56	4	problems	problem	NNS
cord-018265-twp33bb6	56	5	,	,	,
cord-018265-twp33bb6	56	6	several	several	JJ
cord-018265-twp33bb6	56	7	pharmaceutical	pharmaceutical	JJ
cord-018265-twp33bb6	56	8	companies	company	NNS
cord-018265-twp33bb6	56	9	have	have	VBP
cord-018265-twp33bb6	56	10	embarked	embark	VBN
cord-018265-twp33bb6	56	11	themselves	-PRON-	PRP
cord-018265-twp33bb6	56	12	on	on	IN
cord-018265-twp33bb6	56	13	projects	project	NNS
cord-018265-twp33bb6	56	14	for	for	IN
cord-018265-twp33bb6	56	15	the	the	DT
cord-018265-twp33bb6	56	16	development	development	NN
cord-018265-twp33bb6	56	17	of	of	IN
cord-018265-twp33bb6	56	18	vaccines	vaccine	NNS
cord-018265-twp33bb6	56	19	produced	produce	VBN
cord-018265-twp33bb6	56	20	by	by	IN
cord-018265-twp33bb6	56	21	growing	grow	VBG
cord-018265-twp33bb6	56	22	the	the	DT
cord-018265-twp33bb6	56	23	virus	virus	NN
cord-018265-twp33bb6	56	24	on	on	IN
cord-018265-twp33bb6	56	25	cell	cell	NN
cord-018265-twp33bb6	56	26	lines	line	NNS
cord-018265-twp33bb6	56	27	.	.	.
cord-018265-twp33bb6	57	1	The	the	DT
cord-018265-twp33bb6	57	2	influenza	influenza	NN
cord-018265-twp33bb6	57	3	virus	virus	NN
cord-018265-twp33bb6	57	4	can	can	MD
cord-018265-twp33bb6	57	5	be	be	VB
cord-018265-twp33bb6	57	6	adapted	adapt	VBN
cord-018265-twp33bb6	57	7	to	to	TO
cord-018265-twp33bb6	57	8	grow	grow	VB
cord-018265-twp33bb6	57	9	on	on	IN
cord-018265-twp33bb6	57	10	a	a	DT
cord-018265-twp33bb6	57	11	variety	variety	NN
cord-018265-twp33bb6	57	12	of	of	IN
cord-018265-twp33bb6	57	13	mammalian	mammalian	JJ
cord-018265-twp33bb6	57	14	cell	cell	NN
cord-018265-twp33bb6	57	15	lines	line	NNS
cord-018265-twp33bb6	57	16	,	,	,
cord-018265-twp33bb6	57	17	including	include	VBG
cord-018265-twp33bb6	57	18	Vero	Vero	NNP
cord-018265-twp33bb6	57	19	,	,	,
cord-018265-twp33bb6	57	20	PER.C-6	PER.C-6	NNP
cord-018265-twp33bb6	57	21	,	,	,
cord-018265-twp33bb6	57	22	and	and	CC
cord-018265-twp33bb6	57	23	Madin	Madin	NNP
cord-018265-twp33bb6	57	24	-	-	HYPH
cord-018265-twp33bb6	57	25	Darby	Darby	NNP
cord-018265-twp33bb6	57	26	canine	canine	JJ
cord-018265-twp33bb6	57	27	kidney	kidney	NN
cord-018265-twp33bb6	57	28	(	(	-LRB-
cord-018265-twp33bb6	57	29	MDCK	MDCK	NNP
cord-018265-twp33bb6	57	30	)	)	-RRB-
cord-018265-twp33bb6	57	31	cells	cell	NNS
cord-018265-twp33bb6	57	32	[	[	-LRB-
cord-018265-twp33bb6	57	33	6	6	CD
cord-018265-twp33bb6	57	34	]	]	-RRB-
cord-018265-twp33bb6	57	35	[	[	-LRB-
cord-018265-twp33bb6	57	36	7	7	CD
cord-018265-twp33bb6	57	37	]	]	-RRB-
cord-018265-twp33bb6	57	38	[	[	-LRB-
cord-018265-twp33bb6	57	39	8	8	CD
cord-018265-twp33bb6	57	40	]	]	-RRB-
cord-018265-twp33bb6	57	41	.	.	.
cord-018265-twp33bb6	58	1	This	this	DT
cord-018265-twp33bb6	58	2	strategy	strategy	NN
cord-018265-twp33bb6	58	3	would	would	MD
cord-018265-twp33bb6	58	4	also	also	RB
cord-018265-twp33bb6	58	5	improve	improve	VB
cord-018265-twp33bb6	58	6	the	the	DT
cord-018265-twp33bb6	58	7	possibility	possibility	NN
cord-018265-twp33bb6	58	8	of	of	IN
cord-018265-twp33bb6	58	9	up	up	RB
cord-018265-twp33bb6	58	10	-	-	HYPH
cord-018265-twp33bb6	58	11	scaling	scale	VBG
cord-018265-twp33bb6	58	12	vaccine	vaccine	NN
cord-018265-twp33bb6	58	13	production	production	NN
cord-018265-twp33bb6	58	14	in	in	IN
cord-018265-twp33bb6	58	15	face	face	NN
cord-018265-twp33bb6	58	16	of	of	IN
cord-018265-twp33bb6	58	17	a	a	DT
cord-018265-twp33bb6	58	18	pandemic	pandemic	NN
cord-018265-twp33bb6	58	19	spread	spread	NN
cord-018265-twp33bb6	58	20	.	.	.
cord-018265-twp33bb6	59	1	Alternatively	alternatively	RB
cord-018265-twp33bb6	59	2	,	,	,
cord-018265-twp33bb6	59	3	it	-PRON-	PRP
cord-018265-twp33bb6	59	4	would	would	MD
cord-018265-twp33bb6	59	5	be	be	VB
cord-018265-twp33bb6	59	6	possible	possible	JJ
cord-018265-twp33bb6	59	7	to	to	TO
cord-018265-twp33bb6	59	8	develop	develop	VB
cord-018265-twp33bb6	59	9	a	a	DT
cord-018265-twp33bb6	59	10	vaccine	vaccine	NN
cord-018265-twp33bb6	59	11	against	against	IN
cord-018265-twp33bb6	59	12	any	any	DT
cord-018265-twp33bb6	59	13	influenza	influenza	NN
cord-018265-twp33bb6	59	14	virus	virus	NN
cord-018265-twp33bb6	59	15	,	,	,
cord-018265-twp33bb6	59	16	such	such	JJ
cord-018265-twp33bb6	59	17	as	as	IN
cord-018265-twp33bb6	59	18	the	the	DT
cord-018265-twp33bb6	59	19	avian	avian	JJ
cord-018265-twp33bb6	59	20	H5N1	H5N1	NNP
cord-018265-twp33bb6	59	21	strain	strain	NN
cord-018265-twp33bb6	59	22	,	,	,
cord-018265-twp33bb6	59	23	by	by	IN
cord-018265-twp33bb6	59	24	using	use	VBG
cord-018265-twp33bb6	59	25	reverse	reverse	JJ
cord-018265-twp33bb6	59	26	genetics	genetics	NN
cord-018265-twp33bb6	59	27	techniques	technique	NNS
cord-018265-twp33bb6	59	28	[	[	-LRB-
cord-018265-twp33bb6	59	29	9	9	CD
cord-018265-twp33bb6	59	30	]	]	-RRB-
cord-018265-twp33bb6	59	31	(	(	-LRB-
cord-018265-twp33bb6	59	32	see	see	VB
cord-018265-twp33bb6	59	33	below	below	RB
cord-018265-twp33bb6	59	34	in	in	IN
cord-018265-twp33bb6	59	35	advances	advance	NNS
cord-018265-twp33bb6	59	36	in	in	IN
cord-018265-twp33bb6	59	37	vaccinology	vaccinology	NN
cord-018265-twp33bb6	59	38	)	)	-RRB-
cord-018265-twp33bb6	59	39	.	.	.
cord-018265-twp33bb6	60	1	Cold	cold	JJ
cord-018265-twp33bb6	60	2	adaptation	adaptation	NN
cord-018265-twp33bb6	60	3	was	be	VBD
cord-018265-twp33bb6	60	4	found	find	VBN
cord-018265-twp33bb6	60	5	to	to	TO
cord-018265-twp33bb6	60	6	be	be	VB
cord-018265-twp33bb6	60	7	a	a	DT
cord-018265-twp33bb6	60	8	reliable	reliable	JJ
cord-018265-twp33bb6	60	9	and	and	CC
cord-018265-twp33bb6	60	10	efficient	efficient	JJ
cord-018265-twp33bb6	60	11	procedure	procedure	NN
cord-018265-twp33bb6	60	12	for	for	IN
cord-018265-twp33bb6	60	13	the	the	DT
cord-018265-twp33bb6	60	14	derivation	derivation	NN
cord-018265-twp33bb6	60	15	of	of	IN
cord-018265-twp33bb6	60	16	live	live	JJ
cord-018265-twp33bb6	60	17	attenuated	attenuated	JJ
cord-018265-twp33bb6	60	18	viral	viral	JJ
cord-018265-twp33bb6	60	19	vaccine	vaccine	NN
cord-018265-twp33bb6	60	20	strains	strain	NNS
cord-018265-twp33bb6	60	21	for	for	IN
cord-018265-twp33bb6	60	22	humans	human	NNS
cord-018265-twp33bb6	60	23	.	.	.
cord-018265-twp33bb6	61	1	Cold	Cold	NNP
cord-018265-twp33bb6	61	2	-	-	HYPH
cord-018265-twp33bb6	61	3	adapted	adapt	VBN
cord-018265-twp33bb6	61	4	(	(	-LRB-
cord-018265-twp33bb6	61	5	ca	ca	NNP
cord-018265-twp33bb6	61	6	)	)	-RRB-
cord-018265-twp33bb6	61	7	virus	virus	NN
cord-018265-twp33bb6	61	8	strains	strain	NNS
cord-018265-twp33bb6	61	9	can	can	MD
cord-018265-twp33bb6	61	10	grow	grow	VB
cord-018265-twp33bb6	61	11	in	in	IN
cord-018265-twp33bb6	61	12	primary	primary	JJ
cord-018265-twp33bb6	61	13	chick	chick	NN
cord-018265-twp33bb6	61	14	kidney	kidney	NN
cord-018265-twp33bb6	61	15	cells	cell	NNS
cord-018265-twp33bb6	61	16	or	or	CC
cord-018265-twp33bb6	61	17	embryonated	embryonate	VBN
cord-018265-twp33bb6	61	18	eggs	egg	NNS
cord-018265-twp33bb6	61	19	at	at	IN
cord-018265-twp33bb6	61	20	25	25	CD
cord-018265-twp33bb6	61	21	-	-	SYM
cord-018265-twp33bb6	61	22	33	33	CD
cord-018265-twp33bb6	61	23	°	°	NN
cord-018265-twp33bb6	61	24	C	c	NN
cord-018265-twp33bb6	61	25	,	,	,
cord-018265-twp33bb6	61	26	however	however	RB
cord-018265-twp33bb6	61	27	,	,	,
cord-018265-twp33bb6	61	28	they	-PRON-	PRP
cord-018265-twp33bb6	61	29	exhibit	exhibit	VBP
cord-018265-twp33bb6	61	30	a	a	DT
cord-018265-twp33bb6	61	31	reduced	reduce	VBN
cord-018265-twp33bb6	61	32	replication	replication	NN
cord-018265-twp33bb6	61	33	at	at	IN
cord-018265-twp33bb6	61	34	37	37	CD
cord-018265-twp33bb6	61	35	°	°	NN
cord-018265-twp33bb6	61	36	C	c	NN
cord-018265-twp33bb6	61	37	.	.	.
cord-018265-twp33bb6	62	1	The	the	DT
cord-018265-twp33bb6	62	2	process	process	NN
cord-018265-twp33bb6	62	3	of	of	IN
cord-018265-twp33bb6	62	4	genetic	genetic	JJ
cord-018265-twp33bb6	62	5	re	re	NN
cord-018265-twp33bb6	62	6	-	-	NN
cord-018265-twp33bb6	62	7	assortment	assortment	JJ
cord-018265-twp33bb6	62	8	with	with	IN
cord-018265-twp33bb6	62	9	the	the	DT
cord-018265-twp33bb6	62	10	transfer	transfer	NN
cord-018265-twp33bb6	62	11	of	of	IN
cord-018265-twp33bb6	62	12	the	the	DT
cord-018265-twp33bb6	62	13	six	six	CD
cord-018265-twp33bb6	62	14	internal	internal	JJ
cord-018265-twp33bb6	62	15	genes	gene	NNS
cord-018265-twp33bb6	62	16	from	from	IN
cord-018265-twp33bb6	62	17	a	a	DT
cord-018265-twp33bb6	62	18	stable	stable	JJ
cord-018265-twp33bb6	62	19	attenuated	attenuated	JJ
cord-018265-twp33bb6	62	20	ca	ca	MD
cord-018265-twp33bb6	62	21	master	master	NN
cord-018265-twp33bb6	62	22	donor	donor	NN
cord-018265-twp33bb6	62	23	strain	strain	NN
cord-018265-twp33bb6	62	24	of	of	IN
cord-018265-twp33bb6	62	25	influenza	influenza	NN
cord-018265-twp33bb6	62	26	A	a	NN
cord-018265-twp33bb6	62	27	or	or	CC
cord-018265-twp33bb6	62	28	B	b	NN
cord-018265-twp33bb6	62	29	to	to	IN
cord-018265-twp33bb6	62	30	the	the	DT
cord-018265-twp33bb6	62	31	new	new	JJ
cord-018265-twp33bb6	62	32	prevailing	prevail	VBG
cord-018265-twp33bb6	62	33	wild	wild	JJ
cord-018265-twp33bb6	62	34	-	-	HYPH
cord-018265-twp33bb6	62	35	type	type	NN
cord-018265-twp33bb6	62	36	epidemic	epidemic	NN
cord-018265-twp33bb6	62	37	strain	strain	NN
cord-018265-twp33bb6	62	38	has	have	VBZ
cord-018265-twp33bb6	62	39	been	be	VBN
cord-018265-twp33bb6	62	40	used	use	VBN
cord-018265-twp33bb6	62	41	to	to	TO
cord-018265-twp33bb6	62	42	generate	generate	VB
cord-018265-twp33bb6	62	43	attenuated	attenuated	JJ
cord-018265-twp33bb6	62	44	cold	cold	JJ
cord-018265-twp33bb6	62	45	-	-	HYPH
cord-018265-twp33bb6	62	46	reassorted	reassorte	VBN
cord-018265-twp33bb6	62	47	vaccines	vaccine	NNS
cord-018265-twp33bb6	62	48	with	with	IN
cord-018265-twp33bb6	62	49	the	the	DT
cord-018265-twp33bb6	62	50	proper	proper	JJ
cord-018265-twp33bb6	62	51	level	level	NN
cord-018265-twp33bb6	62	52	of	of	IN
cord-018265-twp33bb6	62	53	attenuation	attenuation	NN
cord-018265-twp33bb6	62	54	,	,	,
cord-018265-twp33bb6	62	55	genetic	genetic	JJ
cord-018265-twp33bb6	62	56	stability	stability	NN
cord-018265-twp33bb6	62	57	and	and	CC
cord-018265-twp33bb6	62	58	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	62	59	,	,	,
cord-018265-twp33bb6	62	60	which	which	WDT
cord-018265-twp33bb6	62	61	show	show	VBP
cord-018265-twp33bb6	62	62	low	low	JJ
cord-018265-twp33bb6	62	63	or	or	CC
cord-018265-twp33bb6	62	64	absent	absent	JJ
cord-018265-twp33bb6	62	65	transmissibility	transmissibility	NN
cord-018265-twp33bb6	62	66	[	[	-LRB-
cord-018265-twp33bb6	62	67	10	10	CD
cord-018265-twp33bb6	62	68	]	]	-RRB-
cord-018265-twp33bb6	62	69	.	.	.
cord-018265-twp33bb6	63	1	MedImmune	MedImmune	NNP
cord-018265-twp33bb6	63	2	and	and	CC
cord-018265-twp33bb6	63	3	Wyeth	Wyeth	NNP
cord-018265-twp33bb6	63	4	have	have	VBP
cord-018265-twp33bb6	63	5	developed	develop	VBN
cord-018265-twp33bb6	63	6	along	along	IN
cord-018265-twp33bb6	63	7	these	these	DT
cord-018265-twp33bb6	63	8	lines	line	NNS
cord-018265-twp33bb6	63	9	a	a	DT
cord-018265-twp33bb6	63	10	trivalent	trivalent	JJ
cord-018265-twp33bb6	63	11	live	live	NN
cord-018265-twp33bb6	63	12	ca	ca	NN
cord-018265-twp33bb6	63	13	vaccine	vaccine	NN
cord-018265-twp33bb6	63	14	(	(	-LRB-
cord-018265-twp33bb6	63	15	Flumist	Flumist	NNP
cord-018265-twp33bb6	63	16	)	)	-RRB-
cord-018265-twp33bb6	63	17	for	for	IN
cord-018265-twp33bb6	63	18	intranasal	intranasal	NN
cord-018265-twp33bb6	63	19	spray	spray	NN
cord-018265-twp33bb6	63	20	delivery	delivery	NN
cord-018265-twp33bb6	63	21	,	,	,
cord-018265-twp33bb6	63	22	which	which	WDT
cord-018265-twp33bb6	63	23	was	be	VBD
cord-018265-twp33bb6	63	24	licensed	license	VBN
cord-018265-twp33bb6	63	25	in	in	IN
cord-018265-twp33bb6	63	26	2003	2003	CD
cord-018265-twp33bb6	63	27	.	.	.
cord-018265-twp33bb6	64	1	In	in	IN
cord-018265-twp33bb6	64	2	contrast	contrast	NN
cord-018265-twp33bb6	64	3	,	,	,
cord-018265-twp33bb6	64	4	to	to	IN
cord-018265-twp33bb6	64	5	parenterally	parenterally	RB
cord-018265-twp33bb6	64	6	-	-	HYPH
cord-018265-twp33bb6	64	7	administered	administer	VBN
cord-018265-twp33bb6	64	8	vaccines	vaccine	NNS
cord-018265-twp33bb6	64	9	,	,	,
cord-018265-twp33bb6	64	10	this	this	DT
cord-018265-twp33bb6	64	11	formulation	formulation	NN
cord-018265-twp33bb6	64	12	triggers	trigger	VBZ
cord-018265-twp33bb6	64	13	immune	immune	JJ
cord-018265-twp33bb6	64	14	responses	response	NNS
cord-018265-twp33bb6	64	15	resembling	resemble	VBG
cord-018265-twp33bb6	64	16	those	those	DT
cord-018265-twp33bb6	64	17	observed	observe	VBN
cord-018265-twp33bb6	64	18	after	after	IN
cord-018265-twp33bb6	64	19	natural	natural	JJ
cord-018265-twp33bb6	64	20	infections	infection	NNS
cord-018265-twp33bb6	64	21	[	[	-LRB-
cord-018265-twp33bb6	64	22	11	11	CD
cord-018265-twp33bb6	64	23	]	]	-RRB-
cord-018265-twp33bb6	64	24	.	.	.
cord-018265-twp33bb6	65	1	Despite	despite	IN
cord-018265-twp33bb6	65	2	the	the	DT
cord-018265-twp33bb6	65	3	moderate	moderate	JJ
cord-018265-twp33bb6	65	4	hemagglutination	hemagglutination	NN
cord-018265-twp33bb6	65	5	-	-	HYPH
cord-018265-twp33bb6	65	6	inhibiting	inhibit	VBG
cord-018265-twp33bb6	65	7	antibody	antibody	NN
cord-018265-twp33bb6	65	8	titres	titre	NNS
cord-018265-twp33bb6	65	9	observed	observe	VBN
cord-018265-twp33bb6	65	10	in	in	IN
cord-018265-twp33bb6	65	11	vacinees	vacinee	NNS
cord-018265-twp33bb6	65	12	,	,	,
cord-018265-twp33bb6	65	13	Flumist	Flumist	NNP
cord-018265-twp33bb6	65	14	showed	show	VBD
cord-018265-twp33bb6	65	15	92	92	CD
cord-018265-twp33bb6	65	16	%	%	NN
cord-018265-twp33bb6	65	17	efficacy	efficacy	NN
cord-018265-twp33bb6	65	18	over	over	IN
cord-018265-twp33bb6	65	19	a	a	DT
cord-018265-twp33bb6	65	20	2-year	2-year	CD
cord-018265-twp33bb6	65	21	period	period	NN
cord-018265-twp33bb6	65	22	in	in	IN
cord-018265-twp33bb6	65	23	children	child	NNS
cord-018265-twp33bb6	65	24	,	,	,
cord-018265-twp33bb6	65	25	including	include	VBG
cord-018265-twp33bb6	65	26	protection	protection	NN
cord-018265-twp33bb6	65	27	against	against	IN
cord-018265-twp33bb6	65	28	antigenic	antigenic	JJ
cord-018265-twp33bb6	65	29	variants	variant	NNS
cord-018265-twp33bb6	65	30	that	that	WDT
cord-018265-twp33bb6	65	31	circulated	circulate	VBD
cord-018265-twp33bb6	65	32	during	during	IN
cord-018265-twp33bb6	65	33	the	the	DT
cord-018265-twp33bb6	65	34	second	second	JJ
cord-018265-twp33bb6	65	35	year	year	NN
cord-018265-twp33bb6	65	36	[	[	-LRB-
cord-018265-twp33bb6	65	37	12	12	CD
cord-018265-twp33bb6	65	38	]	]	-RRB-
cord-018265-twp33bb6	65	39	[	[	-LRB-
cord-018265-twp33bb6	65	40	13	13	CD
cord-018265-twp33bb6	65	41	]	]	-RRB-
cord-018265-twp33bb6	65	42	[	[	-LRB-
cord-018265-twp33bb6	65	43	14	14	CD
cord-018265-twp33bb6	65	44	]	]	-RRB-
cord-018265-twp33bb6	65	45	.	.	.
cord-018265-twp33bb6	66	1	This	this	DT
cord-018265-twp33bb6	66	2	ca	ca	MD
cord-018265-twp33bb6	66	3	vaccine	vaccine	NN
cord-018265-twp33bb6	66	4	also	also	RB
cord-018265-twp33bb6	66	5	stimulated	stimulate	VBD
cord-018265-twp33bb6	66	6	the	the	DT
cord-018265-twp33bb6	66	7	production	production	NN
cord-018265-twp33bb6	66	8	of	of	IN
cord-018265-twp33bb6	66	9	nasal	nasal	NNP
cord-018265-twp33bb6	66	10	IgA	IgA	NNP
cord-018265-twp33bb6	66	11	,	,	,
cord-018265-twp33bb6	66	12	as	as	RB
cord-018265-twp33bb6	66	13	well	well	RB
cord-018265-twp33bb6	66	14	as	as	IN
cord-018265-twp33bb6	66	15	T	t	NN
cord-018265-twp33bb6	66	16	-	-	HYPH
cord-018265-twp33bb6	66	17	cell	cell	NN
cord-018265-twp33bb6	66	18	and	and	CC
cord-018265-twp33bb6	66	19	interferon	interferon	NN
cord-018265-twp33bb6	66	20	responses	response	NNS
cord-018265-twp33bb6	66	21	[	[	-LRB-
cord-018265-twp33bb6	66	22	15	15	CD
cord-018265-twp33bb6	66	23	]	]	-RRB-
cord-018265-twp33bb6	66	24	.	.	.
cord-018265-twp33bb6	67	1	The	the	DT
cord-018265-twp33bb6	67	2	cell	cell	NN
cord-018265-twp33bb6	67	3	-	-	HYPH
cord-018265-twp33bb6	67	4	mediated	mediate	VBN
cord-018265-twp33bb6	67	5	immunity	immunity	NN
cord-018265-twp33bb6	67	6	against	against	IN
cord-018265-twp33bb6	67	7	virus	virus	NN
cord-018265-twp33bb6	67	8	matrix	matrix	NNP
cord-018265-twp33bb6	67	9	and	and	CC
cord-018265-twp33bb6	67	10	nucleoprotein	nucleoprotein	NNP
cord-018265-twp33bb6	67	11	antigens	antigen	NNS
cord-018265-twp33bb6	67	12	may	may	MD
cord-018265-twp33bb6	67	13	favour	favour	VB
cord-018265-twp33bb6	67	14	viral	viral	JJ
cord-018265-twp33bb6	67	15	clearance	clearance	NN
cord-018265-twp33bb6	67	16	and	and	CC
cord-018265-twp33bb6	67	17	early	early	JJ
cord-018265-twp33bb6	67	18	recovery	recovery	NN
cord-018265-twp33bb6	67	19	from	from	IN
cord-018265-twp33bb6	67	20	illness	illness	NN
cord-018265-twp33bb6	67	21	[	[	-LRB-
cord-018265-twp33bb6	67	22	3	3	CD
cord-018265-twp33bb6	67	23	]	]	-RRB-
cord-018265-twp33bb6	67	24	.	.	.
cord-018265-twp33bb6	68	1	The	the	DT
cord-018265-twp33bb6	68	2	Advisory	Advisory	NNP
cord-018265-twp33bb6	68	3	committee	committee	NN
cord-018265-twp33bb6	68	4	on	on	IN
cord-018265-twp33bb6	68	5	Immunization	Immunization	NNP
cord-018265-twp33bb6	68	6	Practices	Practices	NNPS
cord-018265-twp33bb6	68	7	has	have	VBZ
cord-018265-twp33bb6	68	8	recommended	recommend	VBN
cord-018265-twp33bb6	68	9	its	-PRON-	PRP$
cord-018265-twp33bb6	68	10	use	use	NN
cord-018265-twp33bb6	68	11	only	only	RB
cord-018265-twp33bb6	68	12	in	in	IN
cord-018265-twp33bb6	68	13	persons	person	NNS
cord-018265-twp33bb6	68	14	from	from	IN
cord-018265-twp33bb6	68	15	5	5	CD
cord-018265-twp33bb6	68	16	to	to	TO
cord-018265-twp33bb6	68	17	49	49	CD
cord-018265-twp33bb6	68	18	years	year	NNS
cord-018265-twp33bb6	68	19	of	of	IN
cord-018265-twp33bb6	68	20	age	age	NN
cord-018265-twp33bb6	68	21	,	,	,
cord-018265-twp33bb6	68	22	since	since	IN
cord-018265-twp33bb6	68	23	side	side	NN
cord-018265-twp33bb6	68	24	-	-	HYPH
cord-018265-twp33bb6	68	25	effects	effect	NNS
cord-018265-twp33bb6	68	26	were	be	VBD
cord-018265-twp33bb6	68	27	observed	observe	VBN
cord-018265-twp33bb6	68	28	in	in	IN
cord-018265-twp33bb6	68	29	young	young	JJ
cord-018265-twp33bb6	68	30	children	child	NNS
cord-018265-twp33bb6	68	31	(	(	-LRB-
cord-018265-twp33bb6	68	32	wheezing	wheeze	VBG
cord-018265-twp33bb6	68	33	,	,	,
cord-018265-twp33bb6	68	34	nasal	nasal	JJ
cord-018265-twp33bb6	68	35	congestion	congestion	NN
cord-018265-twp33bb6	68	36	)	)	-RRB-
cord-018265-twp33bb6	68	37	and	and	CC
cord-018265-twp33bb6	68	38	there	there	EX
cord-018265-twp33bb6	68	39	are	be	VBP
cord-018265-twp33bb6	68	40	no	no	DT
cord-018265-twp33bb6	68	41	data	datum	NNS
cord-018265-twp33bb6	68	42	available	available	JJ
cord-018265-twp33bb6	68	43	for	for	IN
cord-018265-twp33bb6	68	44	elderly	elderly	JJ
cord-018265-twp33bb6	68	45	[	[	-LRB-
cord-018265-twp33bb6	68	46	16	16	CD
cord-018265-twp33bb6	68	47	,	,	,
cord-018265-twp33bb6	68	48	17	17	CD
cord-018265-twp33bb6	68	49	]	]	-RRB-
cord-018265-twp33bb6	68	50	.	.	.
cord-018265-twp33bb6	69	1	Despite	despite	IN
cord-018265-twp33bb6	69	2	its	-PRON-	PRP$
cord-018265-twp33bb6	69	3	remarkable	remarkable	JJ
cord-018265-twp33bb6	69	4	genetic	genetic	JJ
cord-018265-twp33bb6	69	5	stability	stability	NN
cord-018265-twp33bb6	69	6	,	,	,
cord-018265-twp33bb6	69	7	this	this	DT
cord-018265-twp33bb6	69	8	vaccine	vaccine	NN
cord-018265-twp33bb6	69	9	has	have	VBZ
cord-018265-twp33bb6	69	10	to	to	TO
cord-018265-twp33bb6	69	11	be	be	VB
cord-018265-twp33bb6	69	12	kept	keep	VBN
cord-018265-twp33bb6	69	13	at	at	IN
cord-018265-twp33bb6	69	14	-18	-18	NN
cord-018265-twp33bb6	69	15	°	°	NN
cord-018265-twp33bb6	69	16	C	C	NNP
cord-018265-twp33bb6	69	17	.	.	.
cord-018265-twp33bb6	70	1	Thus	thus	RB
cord-018265-twp33bb6	70	2	,	,	,
cord-018265-twp33bb6	70	3	a	a	DT
cord-018265-twp33bb6	70	4	new	new	JJ
cord-018265-twp33bb6	70	5	heat	heat	NN
cord-018265-twp33bb6	70	6	stable	stable	JJ
cord-018265-twp33bb6	70	7	derivative	derivative	NN
cord-018265-twp33bb6	70	8	has	have	VBZ
cord-018265-twp33bb6	70	9	recently	recently	RB
cord-018265-twp33bb6	70	10	been	be	VBN
cord-018265-twp33bb6	70	11	developed	develop	VBN
cord-018265-twp33bb6	70	12	,	,	,
cord-018265-twp33bb6	70	13	which	which	WDT
cord-018265-twp33bb6	70	14	showed	show	VBD
cord-018265-twp33bb6	70	15	good	good	JJ
cord-018265-twp33bb6	70	16	efficacy	efficacy	NN
cord-018265-twp33bb6	70	17	in	in	IN
cord-018265-twp33bb6	70	18	clinical	clinical	JJ
cord-018265-twp33bb6	70	19	trials	trial	NNS
cord-018265-twp33bb6	70	20	[	[	-LRB-
cord-018265-twp33bb6	70	21	1	1	CD
cord-018265-twp33bb6	70	22	]	]	-RRB-
cord-018265-twp33bb6	70	23	.	.	.
cord-018265-twp33bb6	71	1	A	a	DT
cord-018265-twp33bb6	71	2	live	live	JJ
cord-018265-twp33bb6	71	3	vaccine	vaccine	NN
cord-018265-twp33bb6	71	4	based	base	VBN
cord-018265-twp33bb6	71	5	on	on	IN
cord-018265-twp33bb6	71	6	a	a	DT
cord-018265-twp33bb6	71	7	master	master	NN
cord-018265-twp33bb6	71	8	virus	virus	NN
cord-018265-twp33bb6	71	9	strain	strain	NN
cord-018265-twp33bb6	71	10	developed	develop	VBN
cord-018265-twp33bb6	71	11	at	at	IN
cord-018265-twp33bb6	71	12	the	the	DT
cord-018265-twp33bb6	71	13	Institute	Institute	NNP
cord-018265-twp33bb6	71	14	of	of	IN
cord-018265-twp33bb6	71	15	Applied	Applied	NNP
cord-018265-twp33bb6	71	16	Microbiology	Microbiology	NNP
cord-018265-twp33bb6	71	17	(	(	-LRB-
cord-018265-twp33bb6	71	18	Austria	Austria	NNP
cord-018265-twp33bb6	71	19	)	)	-RRB-
cord-018265-twp33bb6	71	20	by	by	IN
cord-018265-twp33bb6	71	21	growing	grow	VBG
cord-018265-twp33bb6	71	22	wild	wild	JJ
cord-018265-twp33bb6	71	23	influenza	influenza	NN
cord-018265-twp33bb6	71	24	virus	virus	NN
cord-018265-twp33bb6	71	25	in	in	IN
cord-018265-twp33bb6	71	26	Vero	Vero	NNP
cord-018265-twp33bb6	71	27	cells	cell	NNS
cord-018265-twp33bb6	71	28	at	at	IN
cord-018265-twp33bb6	71	29	25	25	CD
cord-018265-twp33bb6	71	30	°	°	NN
cord-018265-twp33bb6	71	31	C	c	NN
cord-018265-twp33bb6	71	32	was	be	VBD
cord-018265-twp33bb6	71	33	also	also	RB
cord-018265-twp33bb6	71	34	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	71	35	to	to	TO
cord-018265-twp33bb6	71	36	be	be	VB
cord-018265-twp33bb6	71	37	safe	safe	JJ
cord-018265-twp33bb6	71	38	,	,	,
cord-018265-twp33bb6	71	39	well	well	RB
cord-018265-twp33bb6	71	40	-	-	HYPH
cord-018265-twp33bb6	71	41	tolerated	tolerate	VBN
cord-018265-twp33bb6	71	42	and	and	CC
cord-018265-twp33bb6	71	43	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	71	44	after	after	IN
cord-018265-twp33bb6	71	45	intranasal	intranasal	NN
cord-018265-twp33bb6	71	46	immunization	immunization	NN
cord-018265-twp33bb6	71	47	in	in	IN
cord-018265-twp33bb6	71	48	young	young	JJ
cord-018265-twp33bb6	71	49	adults	adult	NNS
cord-018265-twp33bb6	71	50	[	[	-LRB-
cord-018265-twp33bb6	71	51	18	18	CD
cord-018265-twp33bb6	71	52	]	]	-RRB-
cord-018265-twp33bb6	71	53	.	.	.
cord-018265-twp33bb6	72	1	A	a	DT
cord-018265-twp33bb6	72	2	number	number	NN
cord-018265-twp33bb6	72	3	of	of	IN
cord-018265-twp33bb6	72	4	subunit	subunit	NN
cord-018265-twp33bb6	72	5	-	-	HYPH
cord-018265-twp33bb6	72	6	or	or	CC
cord-018265-twp33bb6	72	7	DNA	dna	NN
cord-018265-twp33bb6	72	8	-	-	HYPH
cord-018265-twp33bb6	72	9	based	base	VBN
cord-018265-twp33bb6	72	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	72	11	are	be	VBP
cord-018265-twp33bb6	72	12	also	also	RB
cord-018265-twp33bb6	72	13	in	in	IN
cord-018265-twp33bb6	72	14	various	various	JJ
cord-018265-twp33bb6	72	15	stages	stage	NNS
cord-018265-twp33bb6	72	16	of	of	IN
cord-018265-twp33bb6	72	17	development	development	NN
cord-018265-twp33bb6	72	18	.	.	.
cord-018265-twp33bb6	73	1	An	an	DT
cord-018265-twp33bb6	73	2	influenza	influenza	NN
cord-018265-twp33bb6	73	3	vaccine	vaccine	NN
cord-018265-twp33bb6	73	4	formulated	formulate	VBN
cord-018265-twp33bb6	73	5	in	in	IN
cord-018265-twp33bb6	73	6	virosomes	virosomes	NNP
cord-018265-twp33bb6	73	7	has	have	VBZ
cord-018265-twp33bb6	73	8	been	be	VBN
cord-018265-twp33bb6	73	9	commercialized	commercialize	VBN
cord-018265-twp33bb6	73	10	by	by	IN
cord-018265-twp33bb6	73	11	Berna	Berna	NNP
cord-018265-twp33bb6	73	12	Biotech	Biotech	NNP
cord-018265-twp33bb6	73	13	(	(	-LRB-
cord-018265-twp33bb6	73	14	Inflexal	Inflexal	NNP
cord-018265-twp33bb6	73	15	®	®	.
cord-018265-twp33bb6	73	16	V	v	NN
cord-018265-twp33bb6	73	17	)	)	-RRB-
cord-018265-twp33bb6	73	18	;	;	:
cord-018265-twp33bb6	73	19	it	-PRON-	PRP
cord-018265-twp33bb6	73	20	contains	contain	VBZ
cord-018265-twp33bb6	73	21	the	the	DT
cord-018265-twp33bb6	73	22	surface	surface	NN
cord-018265-twp33bb6	73	23	spikes	spike	NNS
cord-018265-twp33bb6	73	24	of	of	IN
cord-018265-twp33bb6	73	25	the	the	DT
cord-018265-twp33bb6	73	26	three	three	CD
cord-018265-twp33bb6	73	27	currently	currently	RB
cord-018265-twp33bb6	73	28	circulating	circulate	VBG
cord-018265-twp33bb6	73	29	influenza	influenza	NN
cord-018265-twp33bb6	73	30	virus	virus	NN
cord-018265-twp33bb6	73	31	strains	strain	NNS
cord-018265-twp33bb6	73	32	inserted	insert	VBN
cord-018265-twp33bb6	73	33	in	in	IN
cord-018265-twp33bb6	73	34	vesicle	vesicle	NN
cord-018265-twp33bb6	73	35	membranes	membrane	NNS
cord-018265-twp33bb6	73	36	of	of	IN
cord-018265-twp33bb6	73	37	the	the	DT
cord-018265-twp33bb6	73	38	three	three	CD
cord-018265-twp33bb6	73	39	corresponding	correspond	VBG
cord-018265-twp33bb6	73	40	virus	virus	NN
cord-018265-twp33bb6	73	41	types	type	NNS
cord-018265-twp33bb6	73	42	(	(	-LRB-
cord-018265-twp33bb6	73	43	for	for	IN
cord-018265-twp33bb6	73	44	more	more	JJR
cord-018265-twp33bb6	73	45	details	detail	NNS
cord-018265-twp33bb6	73	46	see	see	VBP
cord-018265-twp33bb6	73	47	section	section	NN
cord-018265-twp33bb6	73	48	"	"	``
cord-018265-twp33bb6	73	49	Pseudoviruses	Pseudoviruses	NNP
cord-018265-twp33bb6	73	50	as	as	IN
cord-018265-twp33bb6	73	51	antigen	antigen	NN
cord-018265-twp33bb6	73	52	delivery	delivery	NN
cord-018265-twp33bb6	73	53	systems	system	NNS
cord-018265-twp33bb6	73	54	"	"	''
cord-018265-twp33bb6	73	55	)	)	-RRB-
cord-018265-twp33bb6	74	1	[	[	-LRB-
cord-018265-twp33bb6	74	2	19	19	CD
cord-018265-twp33bb6	74	3	]	]	-RRB-
cord-018265-twp33bb6	74	4	.	.	.
cord-018265-twp33bb6	75	1	This	this	DT
cord-018265-twp33bb6	75	2	company	company	NN
cord-018265-twp33bb6	75	3	has	have	VBZ
cord-018265-twp33bb6	75	4	also	also	RB
cord-018265-twp33bb6	75	5	developed	develop	VBN
cord-018265-twp33bb6	75	6	a	a	DT
cord-018265-twp33bb6	75	7	virosome	virosome	NN
cord-018265-twp33bb6	75	8	-	-	HYPH
cord-018265-twp33bb6	75	9	based	base	VBN
cord-018265-twp33bb6	75	10	nasal	nasal	NN
cord-018265-twp33bb6	75	11	formulation	formulation	NN
cord-018265-twp33bb6	75	12	.	.	.
cord-018265-twp33bb6	76	1	However	however	RB
cord-018265-twp33bb6	76	2	,	,	,
cord-018265-twp33bb6	76	3	it	-PRON-	PRP
cord-018265-twp33bb6	76	4	was	be	VBD
cord-018265-twp33bb6	76	5	withdrawn	withdraw	VBN
cord-018265-twp33bb6	76	6	from	from	IN
cord-018265-twp33bb6	76	7	the	the	DT
cord-018265-twp33bb6	76	8	market	market	NN
cord-018265-twp33bb6	76	9	due	due	IN
cord-018265-twp33bb6	76	10	to	to	IN
cord-018265-twp33bb6	76	11	the	the	DT
cord-018265-twp33bb6	76	12	presence	presence	NN
cord-018265-twp33bb6	76	13	of	of	IN
cord-018265-twp33bb6	76	14	sideeffects	sideeffect	NNS
cord-018265-twp33bb6	76	15	(	(	-LRB-
cord-018265-twp33bb6	76	16	i.e.	i.e.	FW
cord-018265-twp33bb6	76	17	,	,	,
cord-018265-twp33bb6	76	18	Bell	Bell	NNP
cord-018265-twp33bb6	76	19	's	's	POS
cord-018265-twp33bb6	76	20	palsy	palsy	NN
cord-018265-twp33bb6	76	21	)	)	-RRB-
cord-018265-twp33bb6	76	22	,	,	,
cord-018265-twp33bb6	76	23	which	which	WDT
cord-018265-twp33bb6	76	24	was	be	VBD
cord-018265-twp33bb6	76	25	assumed	assume	VBN
cord-018265-twp33bb6	76	26	to	to	TO
cord-018265-twp33bb6	76	27	be	be	VB
cord-018265-twp33bb6	76	28	linked	link	VBN
cord-018265-twp33bb6	76	29	to	to	IN
cord-018265-twp33bb6	76	30	the	the	DT
cord-018265-twp33bb6	76	31	presence	presence	NN
cord-018265-twp33bb6	76	32	of	of	IN
cord-018265-twp33bb6	76	33	the	the	DT
cord-018265-twp33bb6	76	34	Escherichia	Escherichia	NNP
cord-018265-twp33bb6	76	35	coli	coli	NNS
cord-018265-twp33bb6	76	36	heat	heat	NN
cord-018265-twp33bb6	76	37	labile	labile	JJ
cord-018265-twp33bb6	76	38	toxin	toxin	NN
cord-018265-twp33bb6	76	39	(	(	-LRB-
cord-018265-twp33bb6	76	40	LT	LT	NNP
cord-018265-twp33bb6	76	41	)	)	-RRB-
cord-018265-twp33bb6	76	42	as	as	IN
cord-018265-twp33bb6	76	43	adjuvant	adjuvant	JJ
cord-018265-twp33bb6	76	44	.	.	.
cord-018265-twp33bb6	77	1	Two	two	CD
cord-018265-twp33bb6	77	2	companies	company	NNS
cord-018265-twp33bb6	77	3	,	,	,
cord-018265-twp33bb6	77	4	Yeda	Yeda	NNP
cord-018265-twp33bb6	77	5	and	and	CC
cord-018265-twp33bb6	77	6	BionVax	BionVax	NNP
cord-018265-twp33bb6	77	7	,	,	,
cord-018265-twp33bb6	77	8	are	be	VBP
cord-018265-twp33bb6	77	9	also	also	RB
cord-018265-twp33bb6	77	10	developing	develop	VBG
cord-018265-twp33bb6	77	11	a	a	DT
cord-018265-twp33bb6	77	12	peptide	peptide	NN
cord-018265-twp33bb6	77	13	-	-	HYPH
cord-018265-twp33bb6	77	14	based	base	VBN
cord-018265-twp33bb6	77	15	influenza	influenza	NN
cord-018265-twp33bb6	77	16	vaccine	vaccine	NN
cord-018265-twp33bb6	77	17	for	for	IN
cord-018265-twp33bb6	77	18	nasal	nasal	NNP
cord-018265-twp33bb6	77	19	administration	administration	NNP
cord-018265-twp33bb6	77	20	,	,	,
cord-018265-twp33bb6	77	21	which	which	WDT
cord-018265-twp33bb6	77	22	showed	show	VBD
cord-018265-twp33bb6	77	23	protective	protective	JJ
cord-018265-twp33bb6	77	24	efficacy	efficacy	NN
cord-018265-twp33bb6	77	25	in	in	IN
cord-018265-twp33bb6	77	26	humanized	humanized	JJ
cord-018265-twp33bb6	77	27	mice	mouse	NNS
cord-018265-twp33bb6	77	28	[	[	-LRB-
cord-018265-twp33bb6	77	29	1	1	CD
cord-018265-twp33bb6	77	30	]	]	-RRB-
cord-018265-twp33bb6	77	31	.	.	.
cord-018265-twp33bb6	78	1	A	a	DT
cord-018265-twp33bb6	78	2	subunit	subunit	NN
cord-018265-twp33bb6	78	3	vaccine	vaccine	NN
cord-018265-twp33bb6	78	4	containing	contain	VBG
cord-018265-twp33bb6	78	5	recombinant	recombinant	JJ
cord-018265-twp33bb6	78	6	HA	HA	NNP
cord-018265-twp33bb6	78	7	protein	protein	NN
cord-018265-twp33bb6	78	8	produced	produce	VBD
cord-018265-twp33bb6	78	9	using	use	VBG
cord-018265-twp33bb6	78	10	a	a	DT
cord-018265-twp33bb6	78	11	baculovirus	baculovirus	NN
cord-018265-twp33bb6	78	12	system	system	NN
cord-018265-twp33bb6	78	13	was	be	VBD
cord-018265-twp33bb6	78	14	successfully	successfully	RB
cord-018265-twp33bb6	78	15	tested	test	VBN
cord-018265-twp33bb6	78	16	in	in	IN
cord-018265-twp33bb6	78	17	a	a	DT
cord-018265-twp33bb6	78	18	phase	phase	NN
cord-018265-twp33bb6	78	19	II	ii	CD
cord-018265-twp33bb6	78	20	trial	trial	NN
cord-018265-twp33bb6	78	21	in	in	IN
cord-018265-twp33bb6	78	22	64	64	CD
cord-018265-twp33bb6	78	23	to	to	IN
cord-018265-twp33bb6	78	24	89-year	89-year	JJ
cord-018265-twp33bb6	78	25	-	-	HYPH
cord-018265-twp33bb6	78	26	old	old	JJ
cord-018265-twp33bb6	78	27	volunteers	volunteer	NNS
cord-018265-twp33bb6	78	28	.	.	.
cord-018265-twp33bb6	79	1	An	an	DT
cord-018265-twp33bb6	79	2	epidermal	epidermal	JJ
cord-018265-twp33bb6	79	3	DNA	dna	NN
cord-018265-twp33bb6	79	4	-	-	HYPH
cord-018265-twp33bb6	79	5	based	base	VBN
cord-018265-twp33bb6	79	6	influenza	influenza	NN
cord-018265-twp33bb6	79	7	vaccine	vaccine	NN
cord-018265-twp33bb6	79	8	,	,	,
cord-018265-twp33bb6	79	9	which	which	WDT
cord-018265-twp33bb6	79	10	contained	contain	VBD
cord-018265-twp33bb6	79	11	the	the	DT
cord-018265-twp33bb6	79	12	HA	HA	NNP
cord-018265-twp33bb6	79	13	gene	gene	NN
cord-018265-twp33bb6	79	14	from	from	IN
cord-018265-twp33bb6	79	15	A	A	NNP
cord-018265-twp33bb6	79	16	/	/	SYM
cord-018265-twp33bb6	79	17	Panama/2007/99	panama/2007/99	NN
cord-018265-twp33bb6	79	18	delivered	deliver	VBN
cord-018265-twp33bb6	79	19	by	by	IN
cord-018265-twp33bb6	79	20	particle	particle	NN
cord-018265-twp33bb6	79	21	-	-	HYPH
cord-018265-twp33bb6	79	22	mediated	mediate	VBN
cord-018265-twp33bb6	79	23	epidermal	epidermal	JJ
cord-018265-twp33bb6	79	24	delivery	delivery	NN
cord-018265-twp33bb6	79	25	was	be	VBD
cord-018265-twp33bb6	79	26	also	also	RB
cord-018265-twp33bb6	79	27	tested	test	VBN
cord-018265-twp33bb6	79	28	in	in	IN
cord-018265-twp33bb6	79	29	humans	human	NNS
cord-018265-twp33bb6	79	30	by	by	IN
cord-018265-twp33bb6	79	31	PowderJect	PowderJect	NNP
cord-018265-twp33bb6	79	32	[	[	-LRB-
cord-018265-twp33bb6	79	33	20	20	CD
cord-018265-twp33bb6	79	34	]	]	-RRB-
cord-018265-twp33bb6	79	35	.	.	.
cord-018265-twp33bb6	80	1	Serum	serum	NN
cord-018265-twp33bb6	80	2	haemagglutination	haemagglutination	NN
cord-018265-twp33bb6	80	3	-	-	HYPH
cord-018265-twp33bb6	80	4	inhibition	inhibition	NN
cord-018265-twp33bb6	80	5	antibody	antibody	NN
cord-018265-twp33bb6	80	6	responses	response	NNS
cord-018265-twp33bb6	80	7	were	be	VBD
cord-018265-twp33bb6	80	8	observed	observe	VBN
cord-018265-twp33bb6	80	9	in	in	IN
cord-018265-twp33bb6	80	10	volunteers	volunteer	NNS
cord-018265-twp33bb6	80	11	receiving	receive	VBG
cord-018265-twp33bb6	80	12	a	a	DT
cord-018265-twp33bb6	80	13	single	single	JJ
cord-018265-twp33bb6	80	14	dose	dose	NN
cord-018265-twp33bb6	80	15	of	of	IN
cord-018265-twp33bb6	80	16	1	1	CD
cord-018265-twp33bb6	80	17	,	,	,
cord-018265-twp33bb6	80	18	2	2	CD
cord-018265-twp33bb6	80	19	or	or	CC
cord-018265-twp33bb6	80	20	4	4	CD
cord-018265-twp33bb6	80	21	g	g	NN
cord-018265-twp33bb6	80	22	of	of	IN
cord-018265-twp33bb6	80	23	DNA	DNA	NNP
cord-018265-twp33bb6	80	24	,	,	,
cord-018265-twp33bb6	80	25	with	with	IN
cord-018265-twp33bb6	80	26	the	the	DT
cord-018265-twp33bb6	80	27	strongest	strong	JJS
cord-018265-twp33bb6	80	28	and	and	CC
cord-018265-twp33bb6	80	29	most	most	RBS
cord-018265-twp33bb6	80	30	consistent	consistent	JJ
cord-018265-twp33bb6	80	31	responses	response	NNS
cord-018265-twp33bb6	80	32	in	in	IN
cord-018265-twp33bb6	80	33	subjects	subject	NNS
cord-018265-twp33bb6	80	34	vaccinated	vaccinate	VBN
cord-018265-twp33bb6	80	35	with	with	IN
cord-018265-twp33bb6	80	36	the	the	DT
cord-018265-twp33bb6	80	37	highest	high	JJS
cord-018265-twp33bb6	80	38	dosage	dosage	NN
cord-018265-twp33bb6	80	39	.	.	.
cord-018265-twp33bb6	81	1	Some	some	DT
cord-018265-twp33bb6	81	2	immunization	immunization	NN
cord-018265-twp33bb6	81	3	approaches	approach	NNS
cord-018265-twp33bb6	81	4	aim	aim	VBP
cord-018265-twp33bb6	81	5	at	at	IN
cord-018265-twp33bb6	81	6	the	the	DT
cord-018265-twp33bb6	81	7	development	development	NN
cord-018265-twp33bb6	81	8	of	of	IN
cord-018265-twp33bb6	81	9	a	a	DT
cord-018265-twp33bb6	81	10	universal	universal	JJ
cord-018265-twp33bb6	81	11	vaccine	vaccine	NN
cord-018265-twp33bb6	81	12	with	with	IN
cord-018265-twp33bb6	81	13	a	a	DT
cord-018265-twp33bb6	81	14	broad	broad	JJ
cord-018265-twp33bb6	81	15	spectrum	spectrum	NN
cord-018265-twp33bb6	81	16	of	of	IN
cord-018265-twp33bb6	81	17	protective	protective	JJ
cord-018265-twp33bb6	81	18	activity	activity	NN
cord-018265-twp33bb6	81	19	against	against	IN
cord-018265-twp33bb6	81	20	different	different	JJ
cord-018265-twp33bb6	81	21	influenza	influenza	NN
cord-018265-twp33bb6	81	22	strains	strain	NNS
cord-018265-twp33bb6	81	23	[	[	-LRB-
cord-018265-twp33bb6	81	24	21	21	CD
cord-018265-twp33bb6	81	25	]	]	-RRB-
cord-018265-twp33bb6	81	26	.	.	.
cord-018265-twp33bb6	82	1	Among	among	IN
cord-018265-twp33bb6	82	2	them	-PRON-	PRP
cord-018265-twp33bb6	82	3	,	,	,
cord-018265-twp33bb6	82	4	the	the	DT
cord-018265-twp33bb6	82	5	use	use	NN
cord-018265-twp33bb6	82	6	of	of	IN
cord-018265-twp33bb6	82	7	the	the	DT
cord-018265-twp33bb6	82	8	highly	highly	RB
cord-018265-twp33bb6	82	9	conserved	conserved	JJ
cord-018265-twp33bb6	82	10	transmembrane	transmembrane	NN
cord-018265-twp33bb6	82	11	M2	m2	JJ
cord-018265-twp33bb6	82	12	protein	protein	NN
cord-018265-twp33bb6	82	13	of	of	IN
cord-018265-twp33bb6	82	14	the	the	DT
cord-018265-twp33bb6	82	15	virion	virion	NN
cord-018265-twp33bb6	82	16	can	can	MD
cord-018265-twp33bb6	82	17	be	be	VB
cord-018265-twp33bb6	82	18	mentioned	mention	VBN
cord-018265-twp33bb6	82	19	.	.	.
cord-018265-twp33bb6	83	1	A	a	DT
cord-018265-twp33bb6	83	2	recombinant	recombinant	JJ
cord-018265-twp33bb6	83	3	particulate	particulate	NN
cord-018265-twp33bb6	83	4	vaccine	vaccine	NN
cord-018265-twp33bb6	83	5	has	have	VBZ
cord-018265-twp33bb6	83	6	been	be	VBN
cord-018265-twp33bb6	83	7	engineered	engineer	VBN
cord-018265-twp33bb6	83	8	by	by	IN
cord-018265-twp33bb6	83	9	genetically	genetically	RB
cord-018265-twp33bb6	83	10	fusing	fuse	VBG
cord-018265-twp33bb6	83	11	copies	copy	NNS
cord-018265-twp33bb6	83	12	of	of	IN
cord-018265-twp33bb6	83	13	the	the	DT
cord-018265-twp33bb6	83	14	M2	M2	NNP
cord-018265-twp33bb6	83	15	to	to	IN
cord-018265-twp33bb6	83	16	the	the	DT
cord-018265-twp33bb6	83	17	hepatitis	hepatitis	NN
cord-018265-twp33bb6	83	18	B	B	NNP
cord-018265-twp33bb6	83	19	core	core	NN
cord-018265-twp33bb6	83	20	antigen	antigen	NN
cord-018265-twp33bb6	83	21	(	(	-LRB-
cord-018265-twp33bb6	83	22	HBc	HBc	NNP
cord-018265-twp33bb6	83	23	)	)	-RRB-
cord-018265-twp33bb6	83	24	.	.	.
cord-018265-twp33bb6	84	1	The	the	DT
cord-018265-twp33bb6	84	2	M2-HBc	M2-HBc	NNP
cord-018265-twp33bb6	84	3	fusion	fusion	NN
cord-018265-twp33bb6	84	4	protein	protein	NN
cord-018265-twp33bb6	84	5	spontaneously	spontaneously	RB
cord-018265-twp33bb6	84	6	assembled	assemble	VBD
cord-018265-twp33bb6	84	7	into	into	IN
cord-018265-twp33bb6	84	8	virus	virus	NN
cord-018265-twp33bb6	84	9	-	-	HYPH
cord-018265-twp33bb6	84	10	like	like	JJ
cord-018265-twp33bb6	84	11	particles	particle	NNS
cord-018265-twp33bb6	84	12	(	(	-LRB-
cord-018265-twp33bb6	84	13	VLP	VLP	NNP
cord-018265-twp33bb6	84	14	)	)	-RRB-
cord-018265-twp33bb6	84	15	,	,	,
cord-018265-twp33bb6	84	16	which	which	WDT
cord-018265-twp33bb6	84	17	provided	provide	VBD
cord-018265-twp33bb6	84	18	complete	complete	JJ
cord-018265-twp33bb6	84	19	protection	protection	NN
cord-018265-twp33bb6	84	20	against	against	IN
cord-018265-twp33bb6	84	21	a	a	DT
cord-018265-twp33bb6	84	22	lethal	lethal	JJ
cord-018265-twp33bb6	84	23	challenge	challenge	NN
cord-018265-twp33bb6	84	24	with	with	IN
cord-018265-twp33bb6	85	1	influenza	influenza	NN
cord-018265-twp33bb6	85	2	virus	virus	NN
cord-018265-twp33bb6	85	3	A	a	NN
cord-018265-twp33bb6	85	4	in	in	IN
cord-018265-twp33bb6	85	5	mice	mouse	NNS
cord-018265-twp33bb6	85	6	[	[	-LRB-
cord-018265-twp33bb6	85	7	22	22	CD
cord-018265-twp33bb6	85	8	,	,	,
cord-018265-twp33bb6	85	9	23	23	CD
cord-018265-twp33bb6	85	10	]	]	-RRB-
cord-018265-twp33bb6	85	11	.	.	.
cord-018265-twp33bb6	86	1	Promising	promising	JJ
cord-018265-twp33bb6	86	2	results	result	NNS
cord-018265-twp33bb6	86	3	were	be	VBD
cord-018265-twp33bb6	86	4	also	also	RB
cord-018265-twp33bb6	86	5	obtained	obtain	VBN
cord-018265-twp33bb6	86	6	after	after	IN
cord-018265-twp33bb6	86	7	vaccination	vaccination	NN
cord-018265-twp33bb6	86	8	with	with	IN
cord-018265-twp33bb6	86	9	a	a	DT
cord-018265-twp33bb6	86	10	M2	M2	NNP
cord-018265-twp33bb6	86	11	peptide	peptide	NN
cord-018265-twp33bb6	86	12	conjugated	conjugate	VBN
cord-018265-twp33bb6	86	13	with	with	IN
cord-018265-twp33bb6	86	14	a	a	DT
cord-018265-twp33bb6	86	15	Neisseria	Neisseria	NNP
cord-018265-twp33bb6	86	16	meningitidis	meningitidis	NN
cord-018265-twp33bb6	86	17	outer	outer	JJ
cord-018265-twp33bb6	86	18	membrane	membrane	NN
cord-018265-twp33bb6	86	19	protein	protein	NN
cord-018265-twp33bb6	86	20	complex	complex	NN
cord-018265-twp33bb6	86	21	(	(	-LRB-
cord-018265-twp33bb6	86	22	OMPC	OMPC	NNP
cord-018265-twp33bb6	86	23	)	)	-RRB-
cord-018265-twp33bb6	86	24	in	in	IN
cord-018265-twp33bb6	86	25	monkeys	monkey	NNS
cord-018265-twp33bb6	86	26	[	[	-LRB-
cord-018265-twp33bb6	86	27	24	24	CD
cord-018265-twp33bb6	86	28	]	]	-RRB-
cord-018265-twp33bb6	86	29	.	.	.
cord-018265-twp33bb6	87	1	The	the	DT
cord-018265-twp33bb6	87	2	human	human	JJ
cord-018265-twp33bb6	87	3	PIV	PIV	NNP
cord-018265-twp33bb6	87	4	(	(	-LRB-
cord-018265-twp33bb6	87	5	hPIV	hPIV	NNP
cord-018265-twp33bb6	87	6	)	)	-RRB-
cord-018265-twp33bb6	87	7	consist	consist	VBP
cord-018265-twp33bb6	87	8	of	of	IN
cord-018265-twp33bb6	87	9	four	four	CD
cord-018265-twp33bb6	87	10	serotypes	serotype	NNS
cord-018265-twp33bb6	87	11	,	,	,
cord-018265-twp33bb6	87	12	with	with	IN
cord-018265-twp33bb6	87	13	hPIV-3	hpiv-3	ADD
cord-018265-twp33bb6	87	14	being	be	VBG
cord-018265-twp33bb6	87	15	the	the	DT
cord-018265-twp33bb6	87	16	second	second	JJ
cord-018265-twp33bb6	87	17	leading	leading	JJ
cord-018265-twp33bb6	87	18	cause	cause	NN
cord-018265-twp33bb6	87	19	of	of	IN
cord-018265-twp33bb6	87	20	bronchitis	bronchitis	NN
cord-018265-twp33bb6	87	21	and	and	CC
cord-018265-twp33bb6	87	22	pneumonia	pneumonia	NN
cord-018265-twp33bb6	87	23	in	in	IN
cord-018265-twp33bb6	87	24	infants	infant	NNS
cord-018265-twp33bb6	87	25	.	.	.
cord-018265-twp33bb6	88	1	No	no	DT
cord-018265-twp33bb6	88	2	vaccine	vaccine	NN
cord-018265-twp33bb6	88	3	has	have	VBZ
cord-018265-twp33bb6	88	4	been	be	VBN
cord-018265-twp33bb6	88	5	licensed	license	VBN
cord-018265-twp33bb6	88	6	to	to	IN
cord-018265-twp33bb6	88	7	date	date	NN
cord-018265-twp33bb6	88	8	against	against	IN
cord-018265-twp33bb6	88	9	PIV	PIV	NNP
cord-018265-twp33bb6	88	10	,	,	,
cord-018265-twp33bb6	88	11	however	however	RB
cord-018265-twp33bb6	88	12	,	,	,
cord-018265-twp33bb6	88	13	several	several	JJ
cord-018265-twp33bb6	88	14	approaches	approach	NNS
cord-018265-twp33bb6	88	15	are	be	VBP
cord-018265-twp33bb6	88	16	currently	currently	RB
cord-018265-twp33bb6	88	17	under	under	IN
cord-018265-twp33bb6	88	18	investigation	investigation	NN
cord-018265-twp33bb6	88	19	.	.	.
cord-018265-twp33bb6	89	1	The	the	DT
cord-018265-twp33bb6	89	2	initial	initial	JJ
cord-018265-twp33bb6	89	3	attempts	attempt	NNS
cord-018265-twp33bb6	89	4	to	to	TO
cord-018265-twp33bb6	89	5	provide	provide	VB
cord-018265-twp33bb6	89	6	protection	protection	NN
cord-018265-twp33bb6	89	7	by	by	IN
cord-018265-twp33bb6	89	8	using	use	VBG
cord-018265-twp33bb6	89	9	vaccines	vaccine	NNS
cord-018265-twp33bb6	89	10	based	base	VBN
cord-018265-twp33bb6	89	11	on	on	IN
cord-018265-twp33bb6	89	12	formalin	formalin	NN
cord-018265-twp33bb6	89	13	-	-	HYPH
cord-018265-twp33bb6	89	14	inactivated	inactivate	VBN
cord-018265-twp33bb6	89	15	viruses	virus	NNS
cord-018265-twp33bb6	89	16	failed	fail	VBD
cord-018265-twp33bb6	89	17	.	.	.
cord-018265-twp33bb6	90	1	Subsequent	subsequent	JJ
cord-018265-twp33bb6	90	2	work	work	NN
cord-018265-twp33bb6	90	3	demonstrated	demonstrate	VBD
cord-018265-twp33bb6	90	4	that	that	IN
cord-018265-twp33bb6	90	5	the	the	DT
cord-018265-twp33bb6	90	6	glycoproteins	glycoprotein	NNS
cord-018265-twp33bb6	90	7	haemagglutininneuraminidase	haemagglutininneuraminidase	NN
cord-018265-twp33bb6	90	8	(	(	-LRB-
cord-018265-twp33bb6	90	9	HN	HN	NNP
cord-018265-twp33bb6	90	10	)	)	-RRB-
cord-018265-twp33bb6	90	11	and	and	CC
cord-018265-twp33bb6	90	12	F	F	NNP
cord-018265-twp33bb6	90	13	,	,	,
cord-018265-twp33bb6	90	14	which	which	WDT
cord-018265-twp33bb6	90	15	are	be	VBP
cord-018265-twp33bb6	90	16	responsible	responsible	JJ
cord-018265-twp33bb6	90	17	for	for	IN
cord-018265-twp33bb6	90	18	virus	virus	NN
cord-018265-twp33bb6	90	19	attachment	attachment	NN
cord-018265-twp33bb6	90	20	and	and	CC
cord-018265-twp33bb6	90	21	fusion	fusion	NN
cord-018265-twp33bb6	90	22	,	,	,
cord-018265-twp33bb6	90	23	are	be	VBP
cord-018265-twp33bb6	90	24	able	able	JJ
cord-018265-twp33bb6	90	25	to	to	TO
cord-018265-twp33bb6	90	26	stimulate	stimulate	VB
cord-018265-twp33bb6	90	27	the	the	DT
cord-018265-twp33bb6	90	28	elicitation	elicitation	NN
cord-018265-twp33bb6	90	29	of	of	IN
cord-018265-twp33bb6	90	30	neutralizing	neutralize	VBG
cord-018265-twp33bb6	90	31	antibodies	antibody	NNS
cord-018265-twp33bb6	90	32	in	in	IN
cord-018265-twp33bb6	90	33	animals	animal	NNS
cord-018265-twp33bb6	90	34	.	.	.
cord-018265-twp33bb6	91	1	However	however	RB
cord-018265-twp33bb6	91	2	,	,	,
cord-018265-twp33bb6	91	3	their	-PRON-	PRP$
cord-018265-twp33bb6	91	4	poor	poor	JJ
cord-018265-twp33bb6	91	5	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	91	6	in	in	IN
cord-018265-twp33bb6	91	7	naïve	naïve	JJ
cord-018265-twp33bb6	91	8	subjects	subject	NNS
cord-018265-twp33bb6	91	9	led	lead	VBD
cord-018265-twp33bb6	91	10	to	to	IN
cord-018265-twp33bb6	91	11	the	the	DT
cord-018265-twp33bb6	91	12	currently	currently	RB
cord-018265-twp33bb6	91	13	favoured	favour	VBN
cord-018265-twp33bb6	91	14	approach	approach	NN
cord-018265-twp33bb6	91	15	,	,	,
cord-018265-twp33bb6	91	16	which	which	WDT
cord-018265-twp33bb6	91	17	is	be	VBZ
cord-018265-twp33bb6	91	18	based	base	VBN
cord-018265-twp33bb6	91	19	on	on	IN
cord-018265-twp33bb6	91	20	the	the	DT
cord-018265-twp33bb6	91	21	use	use	NN
cord-018265-twp33bb6	91	22	of	of	IN
cord-018265-twp33bb6	91	23	live	live	JJ
cord-018265-twp33bb6	91	24	attenuated	attenuated	JJ
cord-018265-twp33bb6	91	25	PIV	PIV	NNP
cord-018265-twp33bb6	91	26	.	.	.
cord-018265-twp33bb6	92	1	Live	live	VB
cord-018265-twp33bb6	92	2	attenuated	attenuated	JJ
cord-018265-twp33bb6	92	3	PIV	PIV	NNP
cord-018265-twp33bb6	92	4	vaccines	vaccine	NNS
cord-018265-twp33bb6	92	5	have	have	VBP
cord-018265-twp33bb6	92	6	been	be	VBN
cord-018265-twp33bb6	92	7	developed	develop	VBN
cord-018265-twp33bb6	92	8	from	from	IN
cord-018265-twp33bb6	92	9	both	both	DT
cord-018265-twp33bb6	92	10	human	human	JJ
cord-018265-twp33bb6	92	11	and	and	CC
cord-018265-twp33bb6	92	12	bovine	bovine	JJ
cord-018265-twp33bb6	92	13	strains	strain	NNS
cord-018265-twp33bb6	92	14	,	,	,
cord-018265-twp33bb6	92	15	which	which	WDT
cord-018265-twp33bb6	92	16	are	be	VBP
cord-018265-twp33bb6	92	17	amenable	amenable	JJ
cord-018265-twp33bb6	92	18	for	for	IN
cord-018265-twp33bb6	92	19	delivery	delivery	NN
cord-018265-twp33bb6	92	20	by	by	IN
cord-018265-twp33bb6	92	21	the	the	DT
cord-018265-twp33bb6	92	22	intranasal	intranasal	NN
cord-018265-twp33bb6	92	23	route	route	NN
cord-018265-twp33bb6	92	24	.	.	.
cord-018265-twp33bb6	93	1	Candidate	candidate	NN
cord-018265-twp33bb6	93	2	vaccines	vaccine	NNS
cord-018265-twp33bb6	93	3	should	should	MD
cord-018265-twp33bb6	93	4	be	be	VB
cord-018265-twp33bb6	93	5	able	able	JJ
cord-018265-twp33bb6	93	6	to	to	TO
cord-018265-twp33bb6	93	7	replicate	replicate	VB
cord-018265-twp33bb6	93	8	and	and	CC
cord-018265-twp33bb6	93	9	induce	induce	VB
cord-018265-twp33bb6	93	10	a	a	DT
cord-018265-twp33bb6	93	11	protective	protective	JJ
cord-018265-twp33bb6	93	12	immune	immune	JJ
cord-018265-twp33bb6	93	13	response	response	NN
cord-018265-twp33bb6	93	14	in	in	IN
cord-018265-twp33bb6	93	15	young	young	JJ
cord-018265-twp33bb6	93	16	infants	infant	NNS
cord-018265-twp33bb6	93	17	,	,	,
cord-018265-twp33bb6	93	18	even	even	RB
cord-018265-twp33bb6	93	19	in	in	IN
cord-018265-twp33bb6	93	20	the	the	DT
cord-018265-twp33bb6	93	21	presence	presence	NN
cord-018265-twp33bb6	93	22	of	of	IN
cord-018265-twp33bb6	93	23	maternally	maternally	RB
cord-018265-twp33bb6	93	24	acquired	acquire	VBN
cord-018265-twp33bb6	93	25	antibodies	antibody	NNS
cord-018265-twp33bb6	93	26	.	.	.
cord-018265-twp33bb6	94	1	Two	two	CD
cord-018265-twp33bb6	94	2	main	main	JJ
cord-018265-twp33bb6	94	3	attenuated	attenuated	JJ
cord-018265-twp33bb6	94	4	strains	strain	NNS
cord-018265-twp33bb6	94	5	have	have	VBP
cord-018265-twp33bb6	94	6	been	be	VBN
cord-018265-twp33bb6	94	7	studied	study	VBN
cord-018265-twp33bb6	94	8	in	in	IN
cord-018265-twp33bb6	94	9	detail	detail	NN
cord-018265-twp33bb6	94	10	.	.	.
cord-018265-twp33bb6	95	1	One	one	CD
cord-018265-twp33bb6	95	2	is	be	VBZ
cord-018265-twp33bb6	95	3	the	the	DT
cord-018265-twp33bb6	95	4	hPIV-3	hPIV-3	NNP
cord-018265-twp33bb6	95	5	strain	strain	NN
cord-018265-twp33bb6	96	1	cp45	cp45	NNP
cord-018265-twp33bb6	96	2	,	,	,
cord-018265-twp33bb6	96	3	which	which	WDT
cord-018265-twp33bb6	96	4	was	be	VBD
cord-018265-twp33bb6	96	5	selected	select	VBN
cord-018265-twp33bb6	96	6	after	after	IN
cord-018265-twp33bb6	96	7	45	45	CD
cord-018265-twp33bb6	96	8	passages	passage	NNS
cord-018265-twp33bb6	96	9	of	of	IN
cord-018265-twp33bb6	96	10	the	the	DT
cord-018265-twp33bb6	96	11	virus	virus	NN
cord-018265-twp33bb6	96	12	in	in	IN
cord-018265-twp33bb6	96	13	African	african	JJ
cord-018265-twp33bb6	96	14	green	green	JJ
cord-018265-twp33bb6	96	15	monkey	monkey	NN
cord-018265-twp33bb6	96	16	cells	cell	NNS
cord-018265-twp33bb6	96	17	at	at	IN
cord-018265-twp33bb6	96	18	low	low	JJ
cord-018265-twp33bb6	96	19	temperature	temperature	NN
cord-018265-twp33bb6	96	20	.	.	.
cord-018265-twp33bb6	97	1	The	the	DT
cord-018265-twp33bb6	97	2	other	other	JJ
cord-018265-twp33bb6	97	3	is	be	VBZ
cord-018265-twp33bb6	97	4	a	a	DT
cord-018265-twp33bb6	97	5	bovine	bovine	JJ
cord-018265-twp33bb6	97	6	PIV	PIV	NNP
cord-018265-twp33bb6	97	7	(	(	-LRB-
cord-018265-twp33bb6	97	8	bPIV)-3	bpiv)-3	JJ
cord-018265-twp33bb6	97	9	strain	strain	NN
cord-018265-twp33bb6	97	10	,	,	,
cord-018265-twp33bb6	97	11	which	which	WDT
cord-018265-twp33bb6	97	12	is	be	VBZ
cord-018265-twp33bb6	97	13	antigenically	antigenically	RB
cord-018265-twp33bb6	97	14	related	relate	VBN
cord-018265-twp33bb6	97	15	to	to	IN
cord-018265-twp33bb6	97	16	the	the	DT
cord-018265-twp33bb6	97	17	hPIV-3	hpiv-3	NN
cord-018265-twp33bb6	97	18	,	,	,
cord-018265-twp33bb6	97	19	and	and	CC
cord-018265-twp33bb6	97	20	replicates	replicate	VBZ
cord-018265-twp33bb6	97	21	poorly	poorly	RB
cord-018265-twp33bb6	97	22	in	in	IN
cord-018265-twp33bb6	97	23	humans	human	NNS
cord-018265-twp33bb6	97	24	.	.	.
cord-018265-twp33bb6	98	1	Both	both	DT
cord-018265-twp33bb6	98	2	cp45	cp45	NN
cord-018265-twp33bb6	98	3	and	and	CC
cord-018265-twp33bb6	98	4	bPIV-3	bpiv-3	PRP
cord-018265-twp33bb6	98	5	have	have	VBP
cord-018265-twp33bb6	98	6	been	be	VBN
cord-018265-twp33bb6	98	7	evaluated	evaluate	VBN
cord-018265-twp33bb6	98	8	in	in	IN
cord-018265-twp33bb6	98	9	phase	phase	NN
cord-018265-twp33bb6	98	10	I	I	NNP
cord-018265-twp33bb6	98	11	/	/	SYM
cord-018265-twp33bb6	98	12	II	ii	CD
cord-018265-twp33bb6	98	13	trials	trial	NNS
cord-018265-twp33bb6	98	14	in	in	IN
cord-018265-twp33bb6	98	15	sero	sero	NN
cord-018265-twp33bb6	98	16	-	-	HYPH
cord-018265-twp33bb6	98	17	positive	positive	JJ
cord-018265-twp33bb6	98	18	and	and	CC
cord-018265-twp33bb6	98	19	sero	sero	JJ
cord-018265-twp33bb6	98	20	-	-	HYPH
cord-018265-twp33bb6	98	21	negative	negative	JJ
cord-018265-twp33bb6	98	22	children	child	NNS
cord-018265-twp33bb6	98	23	and	and	CC
cord-018265-twp33bb6	98	24	in	in	IN
cord-018265-twp33bb6	98	25	young	young	JJ
cord-018265-twp33bb6	98	26	infants	infant	NNS
cord-018265-twp33bb6	98	27	.	.	.
cord-018265-twp33bb6	99	1	They	-PRON-	PRP
cord-018265-twp33bb6	99	2	were	be	VBD
cord-018265-twp33bb6	99	3	found	find	VBN
cord-018265-twp33bb6	99	4	to	to	TO
cord-018265-twp33bb6	99	5	be	be	VB
cord-018265-twp33bb6	99	6	over	over	RB
cord-018265-twp33bb6	99	7	-	-	HYPH
cord-018265-twp33bb6	99	8	attenuated	attenuate	VBN
cord-018265-twp33bb6	99	9	in	in	IN
cord-018265-twp33bb6	99	10	sero	sero	NN
cord-018265-twp33bb6	99	11	-	-	HYPH
cord-018265-twp33bb6	99	12	positive	positive	JJ
cord-018265-twp33bb6	99	13	children	child	NNS
cord-018265-twp33bb6	99	14	,	,	,
cord-018265-twp33bb6	99	15	but	but	CC
cord-018265-twp33bb6	99	16	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	99	17	in	in	IN
cord-018265-twp33bb6	99	18	sero	sero	JJ
cord-018265-twp33bb6	99	19	-	-	HYPH
cord-018265-twp33bb6	99	20	negative	negative	JJ
cord-018265-twp33bb6	99	21	children	child	NNS
cord-018265-twp33bb6	99	22	and	and	CC
cord-018265-twp33bb6	99	23	infants	infant	NNS
cord-018265-twp33bb6	99	24	[	[	-LRB-
cord-018265-twp33bb6	99	25	25	25	CD
cord-018265-twp33bb6	99	26	]	]	-RRB-
cord-018265-twp33bb6	99	27	.	.	.
cord-018265-twp33bb6	100	1	However	however	RB
cord-018265-twp33bb6	100	2	,	,	,
cord-018265-twp33bb6	100	3	the	the	DT
cord-018265-twp33bb6	100	4	magnitude	magnitude	NN
cord-018265-twp33bb6	100	5	of	of	IN
cord-018265-twp33bb6	100	6	the	the	DT
cord-018265-twp33bb6	100	7	anti	anti	JJ
cord-018265-twp33bb6	100	8	-	-	JJ
cord-018265-twp33bb6	100	9	HN	HN	NNP
cord-018265-twp33bb6	100	10	response	response	NN
cord-018265-twp33bb6	100	11	was	be	VBD
cord-018265-twp33bb6	100	12	lower	low	JJR
cord-018265-twp33bb6	100	13	in	in	IN
cord-018265-twp33bb6	100	14	children	child	NNS
cord-018265-twp33bb6	100	15	who	who	WP
cord-018265-twp33bb6	100	16	received	receive	VBD
cord-018265-twp33bb6	100	17	the	the	DT
cord-018265-twp33bb6	100	18	bPIV-3	bpiv-3	CD
cord-018265-twp33bb6	100	19	vaccine	vaccine	NN
cord-018265-twp33bb6	100	20	[	[	-LRB-
cord-018265-twp33bb6	100	21	25	25	CD
cord-018265-twp33bb6	100	22	]	]	-RRB-
cord-018265-twp33bb6	100	23	.	.	.
cord-018265-twp33bb6	101	1	This	this	DT
cord-018265-twp33bb6	101	2	prompted	prompt	VBD
cord-018265-twp33bb6	101	3	the	the	DT
cord-018265-twp33bb6	101	4	engineering	engineering	NN
cord-018265-twp33bb6	101	5	of	of	IN
cord-018265-twp33bb6	101	6	chimeric	chimeric	JJ
cord-018265-twp33bb6	101	7	bovine	bovine	JJ
cord-018265-twp33bb6	101	8	/	/	SYM
cord-018265-twp33bb6	101	9	human	human	JJ
cord-018265-twp33bb6	101	10	PIV-3	PIV-3	NNP
cord-018265-twp33bb6	101	11	candidates	candidate	NNS
cord-018265-twp33bb6	101	12	(	(	-LRB-
cord-018265-twp33bb6	101	13	e.g.	e.g.	RB
cord-018265-twp33bb6	101	14	,	,	,
cord-018265-twp33bb6	101	15	hPIV	hPIV	NNP
cord-018265-twp33bb6	101	16	-	-	HYPH
cord-018265-twp33bb6	101	17	Nb	Nb	NNP
cord-018265-twp33bb6	101	18	strain	strain	NN
cord-018265-twp33bb6	101	19	in	in	IN
cord-018265-twp33bb6	101	20	which	which	WDT
cord-018265-twp33bb6	101	21	the	the	DT
cord-018265-twp33bb6	101	22	human	human	JJ
cord-018265-twp33bb6	101	23	nucleocapsid	nucleocapsid	NN
cord-018265-twp33bb6	101	24	is	be	VBZ
cord-018265-twp33bb6	101	25	replaced	replace	VBN
cord-018265-twp33bb6	101	26	by	by	IN
cord-018265-twp33bb6	101	27	the	the	DT
cord-018265-twp33bb6	101	28	bovine	bovine	JJ
cord-018265-twp33bb6	101	29	counterpart	counterpart	NN
cord-018265-twp33bb6	101	30	,	,	,
cord-018265-twp33bb6	101	31	or	or	CC
cord-018265-twp33bb6	101	32	a	a	DT
cord-018265-twp33bb6	101	33	bPIV-3	bpiv-3	NN
cord-018265-twp33bb6	101	34	strain	strain	NN
cord-018265-twp33bb6	101	35	that	that	WDT
cord-018265-twp33bb6	101	36	expresses	express	VBZ
cord-018265-twp33bb6	101	37	the	the	DT
cord-018265-twp33bb6	101	38	F	F	NNP
cord-018265-twp33bb6	101	39	and	and	CC
cord-018265-twp33bb6	101	40	HN	HN	NNP
cord-018265-twp33bb6	101	41	proteins	protein	NNS
cord-018265-twp33bb6	101	42	of	of	IN
cord-018265-twp33bb6	101	43	hPIV-3	hpiv-3	NN
cord-018265-twp33bb6	101	44	)	)	-RRB-
cord-018265-twp33bb6	101	45	.	.	.
cord-018265-twp33bb6	102	1	Attenuated	attenuated	JJ
cord-018265-twp33bb6	102	2	,	,	,
cord-018265-twp33bb6	102	3	chimeric	chimeric	JJ
cord-018265-twp33bb6	102	4	viruses	virus	NNS
cord-018265-twp33bb6	102	5	that	that	WDT
cord-018265-twp33bb6	102	6	contain	contain	VBP
cord-018265-twp33bb6	102	7	PIV-3	PIV-3	NNP
cord-018265-twp33bb6	103	1	cp45	cp45	JJ
cord-018265-twp33bb6	103	2	internal	internal	JJ
cord-018265-twp33bb6	103	3	genes	gene	NNS
cord-018265-twp33bb6	103	4	with	with	IN
cord-018265-twp33bb6	103	5	the	the	DT
cord-018265-twp33bb6	103	6	F	F	NNP
cord-018265-twp33bb6	103	7	and	and	CC
cord-018265-twp33bb6	103	8	HN	HN	NNP
cord-018265-twp33bb6	103	9	genes	gene	NNS
cord-018265-twp33bb6	103	10	from	from	IN
cord-018265-twp33bb6	103	11	either	either	DT
cord-018265-twp33bb6	103	12	PIV-1	PIV-1	NNP
cord-018265-twp33bb6	103	13	or	or	CC
cord-018265-twp33bb6	103	14	PIV-2	PIV-2	NNP
cord-018265-twp33bb6	103	15	have	have	VBP
cord-018265-twp33bb6	103	16	also	also	RB
cord-018265-twp33bb6	103	17	been	be	VBN
cord-018265-twp33bb6	103	18	tested	test	VBN
cord-018265-twp33bb6	103	19	in	in	IN
cord-018265-twp33bb6	103	20	hamsters	hamster	NNS
cord-018265-twp33bb6	103	21	[	[	-LRB-
cord-018265-twp33bb6	103	22	26	26	CD
cord-018265-twp33bb6	103	23	]	]	-RRB-
cord-018265-twp33bb6	103	24	.	.	.
cord-018265-twp33bb6	104	1	Berna	Berna	NNP
cord-018265-twp33bb6	104	2	Biotech	Biotech	NNP
cord-018265-twp33bb6	104	3	is	be	VBZ
cord-018265-twp33bb6	104	4	also	also	RB
cord-018265-twp33bb6	104	5	developing	develop	VBG
cord-018265-twp33bb6	104	6	a	a	DT
cord-018265-twp33bb6	104	7	virosomal	virosomal	JJ
cord-018265-twp33bb6	104	8	formulation	formulation	NN
cord-018265-twp33bb6	104	9	of	of	IN
cord-018265-twp33bb6	104	10	the	the	DT
cord-018265-twp33bb6	104	11	PIV-3	PIV-3	NNP
cord-018265-twp33bb6	104	12	[	[	-LRB-
cord-018265-twp33bb6	104	13	1	1	CD
cord-018265-twp33bb6	104	14	]	]	-RRB-
cord-018265-twp33bb6	104	15	.	.	.
cord-018265-twp33bb6	105	1	Using	use	VBG
cord-018265-twp33bb6	105	2	the	the	DT
cord-018265-twp33bb6	105	3	successful	successful	JJ
cord-018265-twp33bb6	105	4	approach	approach	NN
cord-018265-twp33bb6	105	5	of	of	IN
cord-018265-twp33bb6	105	6	the	the	DT
cord-018265-twp33bb6	105	7	influenza	influenza	NN
cord-018265-twp33bb6	105	8	vaccine	vaccine	NN
cord-018265-twp33bb6	105	9	,	,	,
cord-018265-twp33bb6	105	10	a	a	DT
cord-018265-twp33bb6	105	11	formalin	formalin	NN
cord-018265-twp33bb6	105	12	-	-	HYPH
cord-018265-twp33bb6	105	13	inactivated	inactivate	VBN
cord-018265-twp33bb6	105	14	candidate	candidate	NN
cord-018265-twp33bb6	105	15	against	against	IN
cord-018265-twp33bb6	105	16	the	the	DT
cord-018265-twp33bb6	105	17	respiratory	respiratory	JJ
cord-018265-twp33bb6	105	18	syncytial	syncytial	JJ
cord-018265-twp33bb6	105	19	virus	virus	NN
cord-018265-twp33bb6	105	20	(	(	-LRB-
cord-018265-twp33bb6	105	21	RSV	RSV	NNP
cord-018265-twp33bb6	105	22	)	)	-RRB-
cord-018265-twp33bb6	105	23	was	be	VBD
cord-018265-twp33bb6	105	24	tested	test	VBN
cord-018265-twp33bb6	105	25	in	in	IN
cord-018265-twp33bb6	105	26	children	child	NNS
cord-018265-twp33bb6	105	27	in	in	IN
cord-018265-twp33bb6	105	28	the	the	DT
cord-018265-twp33bb6	105	29	1960s	1960	NNS
cord-018265-twp33bb6	105	30	.	.	.
cord-018265-twp33bb6	106	1	The	the	DT
cord-018265-twp33bb6	106	2	consequence	consequence	NN
cord-018265-twp33bb6	106	3	was	be	VBD
cord-018265-twp33bb6	106	4	the	the	DT
cord-018265-twp33bb6	106	5	hospitalization	hospitalization	NN
cord-018265-twp33bb6	106	6	of	of	IN
cord-018265-twp33bb6	106	7	80	80	CD
cord-018265-twp33bb6	106	8	%	%	NN
cord-018265-twp33bb6	106	9	of	of	IN
cord-018265-twp33bb6	106	10	vaccinees	vaccinee	NNS
cord-018265-twp33bb6	106	11	and	and	CC
cord-018265-twp33bb6	106	12	two	two	CD
cord-018265-twp33bb6	106	13	deaths	death	NNS
cord-018265-twp33bb6	106	14	[	[	-LRB-
cord-018265-twp33bb6	106	15	1	1	CD
cord-018265-twp33bb6	106	16	]	]	-RRB-
cord-018265-twp33bb6	106	17	.	.	.
cord-018265-twp33bb6	107	1	Moreover	moreover	RB
cord-018265-twp33bb6	107	2	,	,	,
cord-018265-twp33bb6	107	3	vaccinated	vaccinated	JJ
cord-018265-twp33bb6	107	4	children	child	NNS
cord-018265-twp33bb6	107	5	also	also	RB
cord-018265-twp33bb6	107	6	suffered	suffer	VBD
cord-018265-twp33bb6	107	7	more	more	RBR
cord-018265-twp33bb6	107	8	severe	severe	JJ
cord-018265-twp33bb6	107	9	disease	disease	NN
cord-018265-twp33bb6	107	10	on	on	IN
cord-018265-twp33bb6	107	11	subsequent	subsequent	JJ
cord-018265-twp33bb6	107	12	exposure	exposure	NN
cord-018265-twp33bb6	107	13	to	to	IN
cord-018265-twp33bb6	107	14	the	the	DT
cord-018265-twp33bb6	107	15	virus	virus	NN
cord-018265-twp33bb6	107	16	,	,	,
cord-018265-twp33bb6	107	17	as	as	IN
cord-018265-twp33bb6	107	18	compared	compare	VBN
cord-018265-twp33bb6	107	19	to	to	IN
cord-018265-twp33bb6	107	20	unvaccinated	unvaccinated	JJ
cord-018265-twp33bb6	107	21	controls	control	NNS
cord-018265-twp33bb6	107	22	[	[	-LRB-
cord-018265-twp33bb6	107	23	27	27	CD
cord-018265-twp33bb6	107	24	]	]	-RRB-
cord-018265-twp33bb6	107	25	.	.	.
cord-018265-twp33bb6	108	1	This	this	DT
cord-018265-twp33bb6	108	2	demonstrated	demonstrate	VBD
cord-018265-twp33bb6	108	3	that	that	IN
cord-018265-twp33bb6	108	4	the	the	DT
cord-018265-twp33bb6	108	5	elicitation	elicitation	NN
cord-018265-twp33bb6	108	6	of	of	IN
cord-018265-twp33bb6	108	7	a	a	DT
cord-018265-twp33bb6	108	8	strong	strong	JJ
cord-018265-twp33bb6	108	9	immune	immune	JJ
cord-018265-twp33bb6	108	10	response	response	NN
cord-018265-twp33bb6	108	11	is	be	VBZ
cord-018265-twp33bb6	108	12	not	not	RB
cord-018265-twp33bb6	108	13	sufficient	sufficient	JJ
cord-018265-twp33bb6	108	14	to	to	TO
cord-018265-twp33bb6	108	15	confer	confer	VB
cord-018265-twp33bb6	108	16	protection	protection	NN
cord-018265-twp33bb6	108	17	against	against	IN
cord-018265-twp33bb6	108	18	disease	disease	NN
cord-018265-twp33bb6	108	19	,	,	,
cord-018265-twp33bb6	108	20	and	and	CC
cord-018265-twp33bb6	108	21	can	can	MD
cord-018265-twp33bb6	108	22	even	even	RB
cord-018265-twp33bb6	108	23	lead	lead	VB
cord-018265-twp33bb6	108	24	to	to	IN
cord-018265-twp33bb6	108	25	immuno	immuno	JJ
cord-018265-twp33bb6	108	26	-	-	JJ
cord-018265-twp33bb6	108	27	pathological	pathological	JJ
cord-018265-twp33bb6	108	28	reactions	reaction	NNS
cord-018265-twp33bb6	108	29	.	.	.
cord-018265-twp33bb6	109	1	Thus	thus	RB
cord-018265-twp33bb6	109	2	,	,	,
cord-018265-twp33bb6	109	3	it	-PRON-	PRP
cord-018265-twp33bb6	109	4	is	be	VBZ
cord-018265-twp33bb6	109	5	essential	essential	JJ
cord-018265-twp33bb6	109	6	to	to	TO
cord-018265-twp33bb6	109	7	stimulate	stimulate	VB
cord-018265-twp33bb6	109	8	the	the	DT
cord-018265-twp33bb6	109	9	"	"	``
cord-018265-twp33bb6	109	10	right	right	JJ
cord-018265-twp33bb6	109	11	"	"	''
cord-018265-twp33bb6	109	12	type	type	NN
cord-018265-twp33bb6	109	13	of	of	IN
cord-018265-twp33bb6	109	14	immune	immune	JJ
cord-018265-twp33bb6	109	15	response	response	NN
cord-018265-twp33bb6	109	16	.	.	.
cord-018265-twp33bb6	110	1	In	in	IN
cord-018265-twp33bb6	110	2	the	the	DT
cord-018265-twp33bb6	110	3	particular	particular	JJ
cord-018265-twp33bb6	110	4	case	case	NN
cord-018265-twp33bb6	110	5	of	of	IN
cord-018265-twp33bb6	110	6	RSV	RSV	NNP
cord-018265-twp33bb6	110	7	,	,	,
cord-018265-twp33bb6	110	8	host	host	NN
cord-018265-twp33bb6	110	9	responses	response	NNS
cord-018265-twp33bb6	110	10	play	play	VBP
cord-018265-twp33bb6	110	11	an	an	DT
cord-018265-twp33bb6	110	12	important	important	JJ
cord-018265-twp33bb6	110	13	role	role	NN
cord-018265-twp33bb6	110	14	in	in	IN
cord-018265-twp33bb6	110	15	the	the	DT
cord-018265-twp33bb6	110	16	pathogenesis	pathogenesis	NN
cord-018265-twp33bb6	110	17	of	of	IN
cord-018265-twp33bb6	110	18	the	the	DT
cord-018265-twp33bb6	110	19	disease	disease	NN
cord-018265-twp33bb6	110	20	,	,	,
cord-018265-twp33bb6	110	21	thereby	thereby	RB
cord-018265-twp33bb6	110	22	making	make	VBG
cord-018265-twp33bb6	110	23	the	the	DT
cord-018265-twp33bb6	110	24	development	development	NN
cord-018265-twp33bb6	110	25	of	of	IN
cord-018265-twp33bb6	110	26	a	a	DT
cord-018265-twp33bb6	110	27	preventive	preventive	JJ
cord-018265-twp33bb6	110	28	vaccine	vaccine	NN
cord-018265-twp33bb6	110	29	extremely	extremely	RB
cord-018265-twp33bb6	110	30	difficult	difficult	JJ
cord-018265-twp33bb6	110	31	.	.	.
cord-018265-twp33bb6	111	1	In	in	IN
cord-018265-twp33bb6	111	2	addition	addition	NN
cord-018265-twp33bb6	111	3	,	,	,
cord-018265-twp33bb6	111	4	naturally	naturally	RB
cord-018265-twp33bb6	111	5	acquired	acquire	VBN
cord-018265-twp33bb6	111	6	immunity	immunity	NN
cord-018265-twp33bb6	111	7	to	to	IN
cord-018265-twp33bb6	111	8	RSV	RSV	NNP
cord-018265-twp33bb6	111	9	is	be	VBZ
cord-018265-twp33bb6	111	10	neither	neither	CC
cord-018265-twp33bb6	111	11	complete	complete	JJ
cord-018265-twp33bb6	111	12	nor	nor	CC
cord-018265-twp33bb6	111	13	long	long	RB
cord-018265-twp33bb6	111	14	-	-	HYPH
cord-018265-twp33bb6	111	15	lasting	last	VBG
cord-018265-twp33bb6	111	16	,	,	,
cord-018265-twp33bb6	111	17	and	and	CC
cord-018265-twp33bb6	111	18	recurrent	recurrent	JJ
cord-018265-twp33bb6	111	19	infections	infection	NNS
cord-018265-twp33bb6	111	20	often	often	RB
cord-018265-twp33bb6	111	21	occur	occur	VBP
cord-018265-twp33bb6	111	22	[	[	-LRB-
cord-018265-twp33bb6	111	23	28	28	CD
cord-018265-twp33bb6	111	24	]	]	-RRB-
cord-018265-twp33bb6	111	25	.	.	.
cord-018265-twp33bb6	112	1	However	however	RB
cord-018265-twp33bb6	112	2	,	,	,
cord-018265-twp33bb6	112	3	older	old	JJR
cord-018265-twp33bb6	112	4	children	child	NNS
cord-018265-twp33bb6	112	5	and	and	CC
cord-018265-twp33bb6	112	6	adults	adult	NNS
cord-018265-twp33bb6	112	7	are	be	VBP
cord-018265-twp33bb6	112	8	usually	usually	RB
cord-018265-twp33bb6	112	9	protected	protect	VBN
cord-018265-twp33bb6	112	10	,	,	,
cord-018265-twp33bb6	112	11	suggesting	suggest	VBG
cord-018265-twp33bb6	112	12	that	that	IN
cord-018265-twp33bb6	112	13	protection	protection	NN
cord-018265-twp33bb6	112	14	against	against	IN
cord-018265-twp33bb6	112	15	severe	severe	JJ
cord-018265-twp33bb6	112	16	disease	disease	NN
cord-018265-twp33bb6	112	17	develops	develop	VBZ
cord-018265-twp33bb6	112	18	after	after	IN
cord-018265-twp33bb6	112	19	several	several	JJ
cord-018265-twp33bb6	112	20	consecutive	consecutive	JJ
cord-018265-twp33bb6	112	21	infections	infection	NNS
cord-018265-twp33bb6	112	22	.	.	.
cord-018265-twp33bb6	113	1	Passive	passive	JJ
cord-018265-twp33bb6	113	2	immunization	immunization	NN
cord-018265-twp33bb6	113	3	with	with	IN
cord-018265-twp33bb6	113	4	RSV	RSV	NNP
cord-018265-twp33bb6	113	5	-	-	HYPH
cord-018265-twp33bb6	113	6	neutralizing	neutralize	VBG
cord-018265-twp33bb6	113	7	immune	immune	JJ
cord-018265-twp33bb6	113	8	globulins	globulin	NNS
cord-018265-twp33bb6	113	9	was	be	VBD
cord-018265-twp33bb6	113	10	also	also	RB
cord-018265-twp33bb6	113	11	shown	show	VBN
cord-018265-twp33bb6	113	12	to	to	TO
cord-018265-twp33bb6	113	13	prevent	prevent	VB
cord-018265-twp33bb6	113	14	RSV	RSV	NNP
cord-018265-twp33bb6	113	15	infection	infection	NN
cord-018265-twp33bb6	113	16	in	in	IN
cord-018265-twp33bb6	113	17	newborns	newborn	NNS
cord-018265-twp33bb6	113	18	with	with	IN
cord-018265-twp33bb6	113	19	underlying	underlying	JJ
cord-018265-twp33bb6	113	20	cardiopulmonary	cardiopulmonary	JJ
cord-018265-twp33bb6	113	21	disease	disease	NN
cord-018265-twp33bb6	113	22	[	[	-LRB-
cord-018265-twp33bb6	113	23	29	29	CD
cord-018265-twp33bb6	113	24	]	]	-RRB-
cord-018265-twp33bb6	113	25	.	.	.
cord-018265-twp33bb6	114	1	This	this	DT
cord-018265-twp33bb6	114	2	demonstrates	demonstrate	VBZ
cord-018265-twp33bb6	114	3	that	that	IN
cord-018265-twp33bb6	114	4	antibodies	antibody	NNS
cord-018265-twp33bb6	114	5	play	play	VBP
cord-018265-twp33bb6	114	6	a	a	DT
cord-018265-twp33bb6	114	7	major	major	JJ
cord-018265-twp33bb6	114	8	role	role	NN
cord-018265-twp33bb6	114	9	in	in	IN
cord-018265-twp33bb6	114	10	protection	protection	NN
cord-018265-twp33bb6	114	11	against	against	IN
cord-018265-twp33bb6	114	12	this	this	DT
cord-018265-twp33bb6	114	13	disease	disease	NN
cord-018265-twp33bb6	114	14	,	,	,
cord-018265-twp33bb6	114	15	whereas	whereas	IN
cord-018265-twp33bb6	114	16	T	t	NN
cord-018265-twp33bb6	114	17	-	-	HYPH
cord-018265-twp33bb6	114	18	cell	cell	NN
cord-018265-twp33bb6	114	19	immunity	immunity	NN
cord-018265-twp33bb6	114	20	targeted	target	VBN
cord-018265-twp33bb6	114	21	to	to	IN
cord-018265-twp33bb6	114	22	internal	internal	JJ
cord-018265-twp33bb6	114	23	viral	viral	JJ
cord-018265-twp33bb6	114	24	proteins	protein	NNS
cord-018265-twp33bb6	114	25	appears	appear	VBZ
cord-018265-twp33bb6	114	26	to	to	TO
cord-018265-twp33bb6	114	27	contribute	contribute	VB
cord-018265-twp33bb6	114	28	to	to	IN
cord-018265-twp33bb6	114	29	clearance	clearance	NN
cord-018265-twp33bb6	114	30	.	.	.
cord-018265-twp33bb6	115	1	Although	although	IN
cord-018265-twp33bb6	115	2	live	live	JJ
cord-018265-twp33bb6	115	3	attenuated	attenuated	JJ
cord-018265-twp33bb6	115	4	vaccines	vaccine	NNS
cord-018265-twp33bb6	115	5	seem	seem	VBP
cord-018265-twp33bb6	115	6	to	to	TO
cord-018265-twp33bb6	115	7	be	be	VB
cord-018265-twp33bb6	115	8	preferable	preferable	JJ
cord-018265-twp33bb6	115	9	for	for	IN
cord-018265-twp33bb6	115	10	immunization	immunization	NN
cord-018265-twp33bb6	115	11	of	of	IN
cord-018265-twp33bb6	115	12	naïve	naïve	JJ
cord-018265-twp33bb6	115	13	infants	infant	NNS
cord-018265-twp33bb6	115	14	,	,	,
cord-018265-twp33bb6	115	15	subunit	subunit	NN
cord-018265-twp33bb6	115	16	vaccines	vaccine	NNS
cord-018265-twp33bb6	115	17	may	may	MD
cord-018265-twp33bb6	115	18	be	be	VB
cord-018265-twp33bb6	115	19	of	of	IN
cord-018265-twp33bb6	115	20	choice	choice	NN
cord-018265-twp33bb6	115	21	for	for	IN
cord-018265-twp33bb6	115	22	elderly	elderly	JJ
cord-018265-twp33bb6	115	23	,	,	,
cord-018265-twp33bb6	115	24	high	high	JJ
cord-018265-twp33bb6	115	25	-	-	HYPH
cord-018265-twp33bb6	115	26	risk	risk	NN
cord-018265-twp33bb6	115	27	children	child	NNS
cord-018265-twp33bb6	115	28	and	and	CC
cord-018265-twp33bb6	115	29	pregnant	pregnant	JJ
cord-018265-twp33bb6	115	30	women	woman	NNS
cord-018265-twp33bb6	115	31	.	.	.
cord-018265-twp33bb6	116	1	Candidate	candidate	NN
cord-018265-twp33bb6	116	2	subunit	subunit	NN
cord-018265-twp33bb6	116	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	116	4	based	base	VBN
cord-018265-twp33bb6	116	5	on	on	IN
cord-018265-twp33bb6	116	6	purified	purify	VBN
cord-018265-twp33bb6	116	7	F	F	NNP
cord-018265-twp33bb6	116	8	proteins	protein	NNS
cord-018265-twp33bb6	116	9	(	(	-LRB-
cord-018265-twp33bb6	116	10	PFP-1	PFP-1	NNP
cord-018265-twp33bb6	116	11	,	,	,
cord-018265-twp33bb6	116	12	-2	-2	NNP
cord-018265-twp33bb6	116	13	and	and	CC
cord-018265-twp33bb6	116	14	-3	-3	NNP
cord-018265-twp33bb6	116	15	)	)	-RRB-
cord-018265-twp33bb6	116	16	were	be	VBD
cord-018265-twp33bb6	116	17	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	116	18	to	to	TO
cord-018265-twp33bb6	116	19	be	be	VB
cord-018265-twp33bb6	116	20	safe	safe	JJ
cord-018265-twp33bb6	116	21	and	and	CC
cord-018265-twp33bb6	116	22	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	116	23	,	,	,
cord-018265-twp33bb6	116	24	even	even	RB
cord-018265-twp33bb6	116	25	during	during	IN
cord-018265-twp33bb6	116	26	pregnancy	pregnancy	NN
cord-018265-twp33bb6	116	27	[	[	-LRB-
cord-018265-twp33bb6	116	28	30	30	CD
cord-018265-twp33bb6	116	29	]	]	-RRB-
cord-018265-twp33bb6	116	30	.	.	.
cord-018265-twp33bb6	117	1	Maternal	maternal	JJ
cord-018265-twp33bb6	117	2	immunization	immunization	NN
cord-018265-twp33bb6	117	3	using	use	VBG
cord-018265-twp33bb6	117	4	a	a	DT
cord-018265-twp33bb6	117	5	PFP	PFP	NNP
cord-018265-twp33bb6	117	6	-	-	HYPH
cord-018265-twp33bb6	117	7	based	base	VBN
cord-018265-twp33bb6	117	8	vaccine	vaccine	NN
cord-018265-twp33bb6	117	9	could	could	MD
cord-018265-twp33bb6	117	10	be	be	VB
cord-018265-twp33bb6	117	11	an	an	DT
cord-018265-twp33bb6	117	12	interesting	interesting	JJ
cord-018265-twp33bb6	117	13	strategy	strategy	NN
cord-018265-twp33bb6	117	14	to	to	TO
cord-018265-twp33bb6	117	15	protect	protect	VB
cord-018265-twp33bb6	117	16	infants	infant	NNS
cord-018265-twp33bb6	117	17	younger	young	JJR
cord-018265-twp33bb6	117	18	than	than	IN
cord-018265-twp33bb6	117	19	6	6	CD
cord-018265-twp33bb6	117	20	months	month	NNS
cord-018265-twp33bb6	117	21	of	of	IN
cord-018265-twp33bb6	117	22	age	age	NN
cord-018265-twp33bb6	117	23	[	[	-LRB-
cord-018265-twp33bb6	117	24	25	25	CD
cord-018265-twp33bb6	117	25	]	]	-RRB-
cord-018265-twp33bb6	117	26	.	.	.
cord-018265-twp33bb6	118	1	However	however	RB
cord-018265-twp33bb6	118	2	,	,	,
cord-018265-twp33bb6	118	3	no	no	DT
cord-018265-twp33bb6	118	4	significant	significant	JJ
cord-018265-twp33bb6	118	5	protection	protection	NN
cord-018265-twp33bb6	118	6	was	be	VBD
cord-018265-twp33bb6	118	7	reported	report	VBN
cord-018265-twp33bb6	118	8	in	in	IN
cord-018265-twp33bb6	118	9	a	a	DT
cord-018265-twp33bb6	118	10	phase	phase	NN
cord-018265-twp33bb6	118	11	III	iii	CD
cord-018265-twp33bb6	118	12	trial	trial	NN
cord-018265-twp33bb6	118	13	performed	perform	VBN
cord-018265-twp33bb6	118	14	on	on	IN
cord-018265-twp33bb6	118	15	children	child	NNS
cord-018265-twp33bb6	118	16	1	1	CD
cord-018265-twp33bb6	118	17	-	-	SYM
cord-018265-twp33bb6	118	18	12	12	CD
cord-018265-twp33bb6	118	19	years	year	NNS
cord-018265-twp33bb6	118	20	of	of	IN
cord-018265-twp33bb6	118	21	age	age	NN
cord-018265-twp33bb6	118	22	with	with	IN
cord-018265-twp33bb6	118	23	cystic	cystic	JJ
cord-018265-twp33bb6	118	24	fibrosis	fibrosis	NN
cord-018265-twp33bb6	118	25	after	after	IN
cord-018265-twp33bb6	118	26	vaccination	vaccination	NN
cord-018265-twp33bb6	118	27	with	with	IN
cord-018265-twp33bb6	118	28	a	a	DT
cord-018265-twp33bb6	118	29	subunit	subunit	NN
cord-018265-twp33bb6	118	30	vaccine	vaccine	NN
cord-018265-twp33bb6	118	31	based	base	VBN
cord-018265-twp33bb6	118	32	on	on	IN
cord-018265-twp33bb6	118	33	PFP-3	PFP-3	NNP
cord-018265-twp33bb6	118	34	[	[	-LRB-
cord-018265-twp33bb6	118	35	31	31	CD
cord-018265-twp33bb6	118	36	]	]	-RRB-
cord-018265-twp33bb6	118	37	.	.	.
cord-018265-twp33bb6	119	1	A	a	DT
cord-018265-twp33bb6	119	2	formulation	formulation	NN
cord-018265-twp33bb6	119	3	based	base	VBN
cord-018265-twp33bb6	119	4	on	on	IN
cord-018265-twp33bb6	119	5	surface	surface	NN
cord-018265-twp33bb6	119	6	glycoproteins	glycoprotein	NNS
cord-018265-twp33bb6	119	7	F	F	NNP
cord-018265-twp33bb6	119	8	and	and	CC
cord-018265-twp33bb6	119	9	G	G	NNP
cord-018265-twp33bb6	119	10	together	together	RB
cord-018265-twp33bb6	119	11	with	with	IN
cord-018265-twp33bb6	119	12	the	the	DT
cord-018265-twp33bb6	119	13	virion	virion	NN
cord-018265-twp33bb6	119	14	matrix	matrix	NN
cord-018265-twp33bb6	119	15	protein	protein	NN
cord-018265-twp33bb6	119	16	M	M	NNP
cord-018265-twp33bb6	119	17	from	from	IN
cord-018265-twp33bb6	119	18	RSV	RSV	NNP
cord-018265-twp33bb6	119	19	-	-	HYPH
cord-018265-twp33bb6	119	20	A	A	NNP
cord-018265-twp33bb6	119	21	was	be	VBD
cord-018265-twp33bb6	119	22	tested	test	VBN
cord-018265-twp33bb6	119	23	in	in	IN
cord-018265-twp33bb6	119	24	healthy	healthy	JJ
cord-018265-twp33bb6	119	25	adult	adult	NN
cord-018265-twp33bb6	119	26	volunteers	volunteer	NNS
cord-018265-twp33bb6	119	27	in	in	IN
cord-018265-twp33bb6	119	28	the	the	DT
cord-018265-twp33bb6	119	29	presence	presence	NN
cord-018265-twp33bb6	119	30	of	of	IN
cord-018265-twp33bb6	119	31	either	either	DT
cord-018265-twp33bb6	119	32	alum	alum	NN
cord-018265-twp33bb6	119	33	or	or	CC
cord-018265-twp33bb6	119	34	polyphosphazene	polyphosphazene	NN
cord-018265-twp33bb6	119	35	as	as	IN
cord-018265-twp33bb6	119	36	an	an	DT
cord-018265-twp33bb6	119	37	adjuvant	adjuvant	NN
cord-018265-twp33bb6	119	38	.	.	.
cord-018265-twp33bb6	120	1	Short	short	JJ
cord-018265-twp33bb6	120	2	-	-	HYPH
cord-018265-twp33bb6	120	3	live	live	JJ
cord-018265-twp33bb6	120	4	neutralizing	neutralize	VBG
cord-018265-twp33bb6	120	5	antibody	antibody	NN
cord-018265-twp33bb6	120	6	responses	response	NNS
cord-018265-twp33bb6	120	7	to	to	IN
cord-018265-twp33bb6	120	8	RSV	RSV	NNP
cord-018265-twp33bb6	120	9	-	-	HYPH
cord-018265-twp33bb6	120	10	A	A	NNP
cord-018265-twp33bb6	120	11	and	and	CC
cord-018265-twp33bb6	120	12	RSV	RSV	NNP
cord-018265-twp33bb6	120	13	-	-	HYPH
cord-018265-twp33bb6	120	14	B	B	NNP
cord-018265-twp33bb6	120	15	were	be	VBD
cord-018265-twp33bb6	120	16	detected	detect	VBN
cord-018265-twp33bb6	120	17	in	in	IN
cord-018265-twp33bb6	120	18	76	76	CD
cord-018265-twp33bb6	120	19	-	-	SYM
cord-018265-twp33bb6	120	20	93	93	CD
cord-018265-twp33bb6	120	21	%	%	NN
cord-018265-twp33bb6	120	22	of	of	IN
cord-018265-twp33bb6	120	23	the	the	DT
cord-018265-twp33bb6	120	24	vaccinees	vaccinee	NNS
cord-018265-twp33bb6	120	25	,	,	,
cord-018265-twp33bb6	120	26	suggesting	suggest	VBG
cord-018265-twp33bb6	120	27	that	that	IN
cord-018265-twp33bb6	120	28	annual	annual	JJ
cord-018265-twp33bb6	120	29	boosting	boosting	NN
cord-018265-twp33bb6	120	30	will	will	MD
cord-018265-twp33bb6	120	31	be	be	VB
cord-018265-twp33bb6	120	32	needed	need	VBN
cord-018265-twp33bb6	120	33	[	[	-LRB-
cord-018265-twp33bb6	120	34	32	32	CD
cord-018265-twp33bb6	120	35	]	]	-RRB-
cord-018265-twp33bb6	121	1	[	[	-LRB-
cord-018265-twp33bb6	121	2	33	33	CD
cord-018265-twp33bb6	121	3	]	]	-RRB-
cord-018265-twp33bb6	121	4	[	[	-LRB-
cord-018265-twp33bb6	121	5	34	34	CD
cord-018265-twp33bb6	121	6	]	]	-RRB-
cord-018265-twp33bb6	121	7	.	.	.
cord-018265-twp33bb6	122	1	The	the	DT
cord-018265-twp33bb6	122	2	central	central	JJ
cord-018265-twp33bb6	122	3	domain	domain	NN
cord-018265-twp33bb6	122	4	of	of	IN
cord-018265-twp33bb6	122	5	the	the	DT
cord-018265-twp33bb6	122	6	G	g	NN
cord-018265-twp33bb6	122	7	protein	protein	NN
cord-018265-twp33bb6	122	8	of	of	IN
cord-018265-twp33bb6	122	9	RSV	RSV	NNP
cord-018265-twp33bb6	122	10	-	-	HYPH
cord-018265-twp33bb6	122	11	A	A	NNP
cord-018265-twp33bb6	122	12	is	be	VBZ
cord-018265-twp33bb6	122	13	relatively	relatively	RB
cord-018265-twp33bb6	122	14	conserved	conserved	JJ
cord-018265-twp33bb6	122	15	among	among	IN
cord-018265-twp33bb6	122	16	viruses	virus	NNS
cord-018265-twp33bb6	122	17	from	from	IN
cord-018265-twp33bb6	122	18	the	the	DT
cord-018265-twp33bb6	122	19	groups	group	NNS
cord-018265-twp33bb6	123	1	A	a	NN
cord-018265-twp33bb6	123	2	and	and	CC
cord-018265-twp33bb6	124	1	B.	B.	NNP
cord-018265-twp33bb6	124	2	Thus	thus	RB
cord-018265-twp33bb6	124	3	,	,	,
cord-018265-twp33bb6	124	4	a	a	DT
cord-018265-twp33bb6	124	5	recombinant	recombinant	JJ
cord-018265-twp33bb6	124	6	vaccine	vaccine	NN
cord-018265-twp33bb6	124	7	candidate	candidate	NN
cord-018265-twp33bb6	124	8	,	,	,
cord-018265-twp33bb6	124	9	BBG2Na	BBG2Na	NNP
cord-018265-twp33bb6	124	10	,	,	,
cord-018265-twp33bb6	124	11	was	be	VBD
cord-018265-twp33bb6	124	12	developed	develop	VBN
cord-018265-twp33bb6	124	13	by	by	IN
cord-018265-twp33bb6	124	14	fusing	fuse	VBG
cord-018265-twp33bb6	124	15	the	the	DT
cord-018265-twp33bb6	124	16	G2Na	g2na	CD
cord-018265-twp33bb6	124	17	domain	domain	NN
cord-018265-twp33bb6	124	18	to	to	IN
cord-018265-twp33bb6	124	19	the	the	DT
cord-018265-twp33bb6	124	20	albumin	albumin	NN
cord-018265-twp33bb6	124	21	binding	bind	VBG
cord-018265-twp33bb6	124	22	region	region	NN
cord-018265-twp33bb6	124	23	of	of	IN
cord-018265-twp33bb6	124	24	streptococcal	streptococcal	JJ
cord-018265-twp33bb6	124	25	protein	protein	NN
cord-018265-twp33bb6	124	26	G.	G.	NNP
cord-018265-twp33bb6	124	27	This	this	DT
cord-018265-twp33bb6	124	28	candidate	candidate	NN
cord-018265-twp33bb6	124	29	was	be	VBD
cord-018265-twp33bb6	124	30	shown	show	VBN
cord-018265-twp33bb6	124	31	to	to	TO
cord-018265-twp33bb6	124	32	be	be	VB
cord-018265-twp33bb6	124	33	moderate	moderate	JJ
cord-018265-twp33bb6	124	34	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	124	35	in	in	IN
cord-018265-twp33bb6	124	36	adult	adult	JJ
cord-018265-twp33bb6	124	37	human	human	JJ
cord-018265-twp33bb6	124	38	volunteers	volunteer	NNS
cord-018265-twp33bb6	124	39	,	,	,
cord-018265-twp33bb6	124	40	but	but	CC
cord-018265-twp33bb6	124	41	its	-PRON-	PRP$
cord-018265-twp33bb6	124	42	clinical	clinical	JJ
cord-018265-twp33bb6	124	43	development	development	NN
cord-018265-twp33bb6	124	44	was	be	VBD
cord-018265-twp33bb6	124	45	interrupted	interrupt	VBN
cord-018265-twp33bb6	124	46	due	due	IN
cord-018265-twp33bb6	124	47	to	to	IN
cord-018265-twp33bb6	124	48	the	the	DT
cord-018265-twp33bb6	124	49	appearance	appearance	NN
cord-018265-twp33bb6	124	50	of	of	IN
cord-018265-twp33bb6	124	51	purpura	purpura	NN
cord-018265-twp33bb6	124	52	in	in	IN
cord-018265-twp33bb6	124	53	vaccinees	vaccinees	NNP
cord-018265-twp33bb6	124	54	[	[	-LRB-
cord-018265-twp33bb6	124	55	1	1	CD
cord-018265-twp33bb6	124	56	]	]	-RRB-
cord-018265-twp33bb6	124	57	.	.	.
cord-018265-twp33bb6	125	1	The	the	DT
cord-018265-twp33bb6	125	2	main	main	JJ
cord-018265-twp33bb6	125	3	two	two	CD
cord-018265-twp33bb6	125	4	difficulties	difficulty	NNS
cord-018265-twp33bb6	125	5	associated	associate	VBN
cord-018265-twp33bb6	125	6	with	with	IN
cord-018265-twp33bb6	125	7	the	the	DT
cord-018265-twp33bb6	125	8	generation	generation	NN
cord-018265-twp33bb6	125	9	of	of	IN
cord-018265-twp33bb6	125	10	live	live	JJ
cord-018265-twp33bb6	125	11	attenuated	attenuated	JJ
cord-018265-twp33bb6	125	12	vaccines	vaccine	NNS
cord-018265-twp33bb6	125	13	against	against	IN
cord-018265-twp33bb6	125	14	RSV	RSV	NNP
cord-018265-twp33bb6	125	15	are	be	VBP
cord-018265-twp33bb6	125	16	over	over	RB
cord-018265-twp33bb6	125	17	-	-	HYPH
cord-018265-twp33bb6	125	18	or	or	CC
cord-018265-twp33bb6	125	19	under	under	IN
cord-018265-twp33bb6	125	20	-	-	HYPH
cord-018265-twp33bb6	125	21	attenuation	attenuation	NN
cord-018265-twp33bb6	125	22	of	of	IN
cord-018265-twp33bb6	125	23	the	the	DT
cord-018265-twp33bb6	125	24	virus	virus	NN
cord-018265-twp33bb6	125	25	and	and	CC
cord-018265-twp33bb6	125	26	limited	limited	JJ
cord-018265-twp33bb6	125	27	genetic	genetic	JJ
cord-018265-twp33bb6	125	28	stability	stability	NN
cord-018265-twp33bb6	125	29	.	.	.
cord-018265-twp33bb6	126	1	Temperature	temperature	NN
cord-018265-twp33bb6	126	2	-	-	HYPH
cord-018265-twp33bb6	126	3	sensitive	sensitive	JJ
cord-018265-twp33bb6	126	4	(	(	-LRB-
cord-018265-twp33bb6	126	5	ts	ts	NNP
cord-018265-twp33bb6	126	6	)	)	-RRB-
cord-018265-twp33bb6	126	7	,	,	,
cord-018265-twp33bb6	126	8	ca	ca	NNP
cord-018265-twp33bb6	126	9	and	and	CC
cord-018265-twp33bb6	127	1	cold	cold	JJ
cord-018265-twp33bb6	127	2	-	-	HYPH
cord-018265-twp33bb6	127	3	passaged	passaged	JJ
cord-018265-twp33bb6	127	4	(	(	-LRB-
cord-018265-twp33bb6	127	5	cp	cp	JJ
cord-018265-twp33bb6	127	6	)	)	-RRB-
cord-018265-twp33bb6	127	7	mutant	mutant	JJ
cord-018265-twp33bb6	127	8	viral	viral	JJ
cord-018265-twp33bb6	127	9	strains	strain	NNS
cord-018265-twp33bb6	127	10	have	have	VBP
cord-018265-twp33bb6	127	11	been	be	VBN
cord-018265-twp33bb6	127	12	generated	generate	VBN
cord-018265-twp33bb6	127	13	.	.	.
cord-018265-twp33bb6	128	1	Despite	despite	IN
cord-018265-twp33bb6	128	2	the	the	DT
cord-018265-twp33bb6	128	3	attenuation	attenuation	NN
cord-018265-twp33bb6	128	4	shown	show	VBN
cord-018265-twp33bb6	128	5	in	in	IN
cord-018265-twp33bb6	128	6	adults	adult	NNS
cord-018265-twp33bb6	128	7	and	and	CC
cord-018265-twp33bb6	128	8	sero	sero	NN
cord-018265-twp33bb6	128	9	-	-	HYPH
cord-018265-twp33bb6	128	10	positive	positive	JJ
cord-018265-twp33bb6	128	11	children	child	NNS
cord-018265-twp33bb6	128	12	,	,	,
cord-018265-twp33bb6	128	13	cpts	cpt	NNS
cord-018265-twp33bb6	128	14	mutants	mutant	NNS
cord-018265-twp33bb6	128	15	still	still	RB
cord-018265-twp33bb6	128	16	caused	cause	VBD
cord-018265-twp33bb6	128	17	moderate	moderate	JJ
cord-018265-twp33bb6	128	18	congestion	congestion	NN
cord-018265-twp33bb6	128	19	in	in	IN
cord-018265-twp33bb6	128	20	the	the	DT
cord-018265-twp33bb6	128	21	upper	upper	JJ
cord-018265-twp33bb6	128	22	respiratory	respiratory	JJ
cord-018265-twp33bb6	128	23	tract	tract	NN
cord-018265-twp33bb6	128	24	of	of	IN
cord-018265-twp33bb6	128	25	sero	sero	NN
cord-018265-twp33bb6	128	26	-	-	HYPH
cord-018265-twp33bb6	128	27	negative	negative	JJ
cord-018265-twp33bb6	128	28	infants	infant	NNS
cord-018265-twp33bb6	128	29	(	(	-LRB-
cord-018265-twp33bb6	128	30	1	1	CD
cord-018265-twp33bb6	128	31	-	-	SYM
cord-018265-twp33bb6	128	32	2	2	CD
cord-018265-twp33bb6	128	33	months	month	NNS
cord-018265-twp33bb6	128	34	old	old	JJ
cord-018265-twp33bb6	128	35	)	)	-RRB-
cord-018265-twp33bb6	128	36	[	[	-LRB-
cord-018265-twp33bb6	128	37	35	35	CD
cord-018265-twp33bb6	128	38	]	]	-RRB-
cord-018265-twp33bb6	128	39	.	.	.
cord-018265-twp33bb6	129	1	Recombinant	recombinant	JJ
cord-018265-twp33bb6	129	2	RSV	RSV	NNP
cord-018265-twp33bb6	129	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	129	4	with	with	IN
cord-018265-twp33bb6	129	5	deletions	deletion	NNS
cord-018265-twp33bb6	129	6	in	in	IN
cord-018265-twp33bb6	129	7	non	non	JJ
cord-018265-twp33bb6	129	8	essential	essential	JJ
cord-018265-twp33bb6	129	9	genes	gene	NNS
cord-018265-twp33bb6	129	10	(	(	-LRB-
cord-018265-twp33bb6	129	11	e.g.	e.g.	RB
cord-018265-twp33bb6	129	12	,	,	,
cord-018265-twp33bb6	129	13	SH	SH	NNP
cord-018265-twp33bb6	129	14	,	,	,
cord-018265-twp33bb6	129	15	NS1	ns1	NN
cord-018265-twp33bb6	129	16	or	or	CC
cord-018265-twp33bb6	129	17	NS2	NS2	NNP
cord-018265-twp33bb6	129	18	)	)	-RRB-
cord-018265-twp33bb6	129	19	,	,	,
cord-018265-twp33bb6	129	20	which	which	WDT
cord-018265-twp33bb6	129	21	also	also	RB
cord-018265-twp33bb6	129	22	carry	carry	VBP
cord-018265-twp33bb6	129	23	cp	cp	NN
cord-018265-twp33bb6	129	24	and	and	CC
cord-018265-twp33bb6	129	25	ts	ts	NNP
cord-018265-twp33bb6	129	26	mutations	mutation	NNS
cord-018265-twp33bb6	129	27	in	in	IN
cord-018265-twp33bb6	129	28	essential	essential	JJ
cord-018265-twp33bb6	129	29	genes	gene	NNS
cord-018265-twp33bb6	129	30	are	be	VBP
cord-018265-twp33bb6	129	31	currently	currently	RB
cord-018265-twp33bb6	129	32	being	be	VBG
cord-018265-twp33bb6	129	33	evaluated	evaluate	VBN
cord-018265-twp33bb6	129	34	[	[	-LRB-
cord-018265-twp33bb6	129	35	1	1	CD
cord-018265-twp33bb6	129	36	]	]	-RRB-
cord-018265-twp33bb6	129	37	.	.	.
cord-018265-twp33bb6	130	1	Through	through	IN
cord-018265-twp33bb6	130	2	recombinant	recombinant	JJ
cord-018265-twp33bb6	130	3	DNA	dna	NN
cord-018265-twp33bb6	130	4	technology	technology	NN
cord-018265-twp33bb6	130	5	chimeric	chimeric	JJ
cord-018265-twp33bb6	130	6	viruses	virus	NNS
cord-018265-twp33bb6	130	7	were	be	VBD
cord-018265-twp33bb6	130	8	engineered	engineer	VBN
cord-018265-twp33bb6	130	9	,	,	,
cord-018265-twp33bb6	130	10	which	which	WDT
cord-018265-twp33bb6	130	11	contain	contain	VBP
cord-018265-twp33bb6	130	12	the	the	DT
cord-018265-twp33bb6	130	13	genes	gene	NNS
cord-018265-twp33bb6	130	14	of	of	IN
cord-018265-twp33bb6	130	15	hPIV-3	hpiv-3	NN
cord-018265-twp33bb6	130	16	surface	surface	NN
cord-018265-twp33bb6	130	17	glycoproteins	glycoprotein	NNS
cord-018265-twp33bb6	130	18	F	F	NNP
cord-018265-twp33bb6	130	19	and	and	CC
cord-018265-twp33bb6	130	20	NH	NH	NNP
cord-018265-twp33bb6	130	21	together	together	RB
cord-018265-twp33bb6	130	22	with	with	IN
cord-018265-twp33bb6	130	23	those	those	DT
cord-018265-twp33bb6	130	24	of	of	IN
cord-018265-twp33bb6	130	25	RSV	RSV	NNP
cord-018265-twp33bb6	130	26	glycoproteins	glycoprotein	NNS
cord-018265-twp33bb6	130	27	F	F	NNP
cord-018265-twp33bb6	130	28	and	and	CC
cord-018265-twp33bb6	130	29	G	g	NN
cord-018265-twp33bb6	130	30	in	in	IN
cord-018265-twp33bb6	130	31	a	a	DT
cord-018265-twp33bb6	130	32	bPIV-3	bpiv-3	CD
cord-018265-twp33bb6	130	33	genetic	genetic	JJ
cord-018265-twp33bb6	130	34	background	background	NN
cord-018265-twp33bb6	130	35	.	.	.
cord-018265-twp33bb6	131	1	One	one	CD
cord-018265-twp33bb6	131	2	of	of	IN
cord-018265-twp33bb6	131	3	these	these	DT
cord-018265-twp33bb6	131	4	candidates	candidate	NNS
cord-018265-twp33bb6	131	5	was	be	VBD
cord-018265-twp33bb6	131	6	found	find	VBN
cord-018265-twp33bb6	131	7	to	to	TO
cord-018265-twp33bb6	131	8	be	be	VB
cord-018265-twp33bb6	131	9	attenuated	attenuated	JJ
cord-018265-twp33bb6	131	10	and	and	CC
cord-018265-twp33bb6	131	11	able	able	JJ
cord-018265-twp33bb6	131	12	to	to	TO
cord-018265-twp33bb6	131	13	induce	induce	VB
cord-018265-twp33bb6	131	14	the	the	DT
cord-018265-twp33bb6	131	15	elicitation	elicitation	NN
cord-018265-twp33bb6	131	16	of	of	IN
cord-018265-twp33bb6	131	17	immune	immune	JJ
cord-018265-twp33bb6	131	18	responses	response	NNS
cord-018265-twp33bb6	131	19	against	against	IN
cord-018265-twp33bb6	131	20	both	both	DT
cord-018265-twp33bb6	131	21	hPIV-3	hPIV-3	NNP
cord-018265-twp33bb6	131	22	and	and	CC
cord-018265-twp33bb6	131	23	RSV	RSV	NNP
cord-018265-twp33bb6	131	24	in	in	IN
cord-018265-twp33bb6	131	25	rhesus	rhesu	NNS
cord-018265-twp33bb6	131	26	monkeys	monkey	NNS
cord-018265-twp33bb6	131	27	[	[	-LRB-
cord-018265-twp33bb6	131	28	36	36	CD
cord-018265-twp33bb6	131	29	]	]	-RRB-
cord-018265-twp33bb6	131	30	.	.	.
cord-018265-twp33bb6	132	1	Similarly	similarly	RB
cord-018265-twp33bb6	132	2	,	,	,
cord-018265-twp33bb6	132	3	a	a	DT
cord-018265-twp33bb6	132	4	bPIV-3	bpiv-3	NN
cord-018265-twp33bb6	132	5	genome	genome	NN
cord-018265-twp33bb6	132	6	was	be	VBD
cord-018265-twp33bb6	132	7	engineered	engineer	VBN
cord-018265-twp33bb6	132	8	to	to	TO
cord-018265-twp33bb6	132	9	express	express	VB
cord-018265-twp33bb6	132	10	hPIV-3	hPIV-3	NNP
cord-018265-twp33bb6	132	11	F	F	NNP
cord-018265-twp33bb6	132	12	and	and	CC
cord-018265-twp33bb6	132	13	HN	HN	NNP
cord-018265-twp33bb6	132	14	proteins	protein	NNS
cord-018265-twp33bb6	132	15	and	and	CC
cord-018265-twp33bb6	132	16	either	either	CC
cord-018265-twp33bb6	132	17	native	native	JJ
cord-018265-twp33bb6	132	18	or	or	CC
cord-018265-twp33bb6	132	19	soluble	soluble	JJ
cord-018265-twp33bb6	132	20	RSV	RSV	NNP
cord-018265-twp33bb6	132	21	F	F	NNP
cord-018265-twp33bb6	132	22	protein	protein	NN
cord-018265-twp33bb6	132	23	[	[	-LRB-
cord-018265-twp33bb6	132	24	37	37	CD
cord-018265-twp33bb6	132	25	]	]	-RRB-
cord-018265-twp33bb6	132	26	.	.	.
cord-018265-twp33bb6	133	1	The	the	DT
cord-018265-twp33bb6	133	2	resulting	result	VBG
cord-018265-twp33bb6	133	3	strain	strain	NN
cord-018265-twp33bb6	133	4	,	,	,
cord-018265-twp33bb6	133	5	which	which	WDT
cord-018265-twp33bb6	133	6	induced	induce	VBD
cord-018265-twp33bb6	133	7	RSV	RSV	NNP
cord-018265-twp33bb6	133	8	neutralizing	neutralize	VBG
cord-018265-twp33bb6	133	9	antibodies	antibody	NNS
cord-018265-twp33bb6	133	10	and	and	CC
cord-018265-twp33bb6	133	11	protective	protective	JJ
cord-018265-twp33bb6	133	12	immunity	immunity	NN
cord-018265-twp33bb6	133	13	against	against	IN
cord-018265-twp33bb6	133	14	RSV	RSV	NNP
cord-018265-twp33bb6	133	15	challenge	challenge	NN
cord-018265-twp33bb6	133	16	in	in	IN
cord-018265-twp33bb6	133	17	African	african	JJ
cord-018265-twp33bb6	133	18	Green	Green	NNP
cord-018265-twp33bb6	133	19	monkeys	monkey	NNS
cord-018265-twp33bb6	133	20	,	,	,
cord-018265-twp33bb6	133	21	needs	need	VBZ
cord-018265-twp33bb6	133	22	to	to	TO
cord-018265-twp33bb6	133	23	be	be	VB
cord-018265-twp33bb6	133	24	tested	test	VBN
cord-018265-twp33bb6	133	25	for	for	IN
cord-018265-twp33bb6	133	26	safety	safety	NN
cord-018265-twp33bb6	133	27	and	and	CC
cord-018265-twp33bb6	133	28	efficacy	efficacy	NN
cord-018265-twp33bb6	133	29	against	against	IN
cord-018265-twp33bb6	133	30	RSV	RSV	NNP
cord-018265-twp33bb6	133	31	and	and	CC
cord-018265-twp33bb6	133	32	PIV-3	PIV-3	NNP
cord-018265-twp33bb6	133	33	in	in	IN
cord-018265-twp33bb6	133	34	infants	infant	NNS
cord-018265-twp33bb6	133	35	.	.	.
cord-018265-twp33bb6	134	1	This	this	DT
cord-018265-twp33bb6	134	2	emerging	emerge	VBG
cord-018265-twp33bb6	134	3	disease	disease	NN
cord-018265-twp33bb6	134	4	was	be	VBD
cord-018265-twp33bb6	134	5	originally	originally	RB
cord-018265-twp33bb6	134	6	described	describe	VBN
cord-018265-twp33bb6	134	7	in	in	IN
cord-018265-twp33bb6	134	8	the	the	DT
cord-018265-twp33bb6	134	9	Guangdong	Guangdong	NNP
cord-018265-twp33bb6	134	10	province	province	NN
cord-018265-twp33bb6	134	11	of	of	IN
cord-018265-twp33bb6	134	12	China	China	NNP
cord-018265-twp33bb6	134	13	in	in	IN
cord-018265-twp33bb6	134	14	2002	2002	CD
cord-018265-twp33bb6	134	15	.	.	.
cord-018265-twp33bb6	135	1	Even	even	RB
cord-018265-twp33bb6	135	2	when	when	WRB
cord-018265-twp33bb6	135	3	the	the	DT
cord-018265-twp33bb6	135	4	global	global	JJ
cord-018265-twp33bb6	135	5	outbreak	outbreak	NN
cord-018265-twp33bb6	135	6	of	of	IN
cord-018265-twp33bb6	135	7	SARS	SARS	NNP
cord-018265-twp33bb6	135	8	was	be	VBD
cord-018265-twp33bb6	135	9	under	under	IN
cord-018265-twp33bb6	135	10	control	control	NN
cord-018265-twp33bb6	135	11	in	in	IN
cord-018265-twp33bb6	135	12	2003	2003	CD
cord-018265-twp33bb6	135	13	,	,	,
cord-018265-twp33bb6	135	14	new	new	JJ
cord-018265-twp33bb6	135	15	infections	infection	NNS
cord-018265-twp33bb6	135	16	were	be	VBD
cord-018265-twp33bb6	135	17	reported	report	VBN
cord-018265-twp33bb6	135	18	in	in	IN
cord-018265-twp33bb6	135	19	persons	person	NNS
cord-018265-twp33bb6	135	20	who	who	WP
cord-018265-twp33bb6	135	21	had	have	VBD
cord-018265-twp33bb6	135	22	contacts	contact	NNS
cord-018265-twp33bb6	135	23	with	with	IN
cord-018265-twp33bb6	135	24	animals	animal	NNS
cord-018265-twp33bb6	135	25	in	in	IN
cord-018265-twp33bb6	135	26	2003	2003	CD
cord-018265-twp33bb6	135	27	and	and	CC
cord-018265-twp33bb6	135	28	2004	2004	CD
cord-018265-twp33bb6	135	29	[	[	-LRB-
cord-018265-twp33bb6	135	30	38	38	CD
cord-018265-twp33bb6	135	31	]	]	-RRB-
cord-018265-twp33bb6	135	32	.	.	.
cord-018265-twp33bb6	136	1	The	the	DT
cord-018265-twp33bb6	136	2	typical	typical	JJ
cord-018265-twp33bb6	136	3	SARS	SARS	NNP
cord-018265-twp33bb6	136	4	-	-	HYPH
cord-018265-twp33bb6	136	5	CoV	CoV	NNP
cord-018265-twp33bb6	136	6	-	-	HYPH
cord-018265-twp33bb6	136	7	like	like	JJ
cord-018265-twp33bb6	136	8	virus	virus	NN
cord-018265-twp33bb6	136	9	is	be	VBZ
cord-018265-twp33bb6	136	10	not	not	RB
cord-018265-twp33bb6	136	11	transmitted	transmit	VBN
cord-018265-twp33bb6	136	12	from	from	IN
cord-018265-twp33bb6	136	13	animals	animal	NNS
cord-018265-twp33bb6	136	14	to	to	IN
cord-018265-twp33bb6	136	15	humans	human	NNS
cord-018265-twp33bb6	136	16	.	.	.
cord-018265-twp33bb6	137	1	However	however	RB
cord-018265-twp33bb6	137	2	,	,	,
cord-018265-twp33bb6	137	3	under	under	IN
cord-018265-twp33bb6	137	4	certain	certain	JJ
cord-018265-twp33bb6	137	5	conditions	condition	NNS
cord-018265-twp33bb6	137	6	the	the	DT
cord-018265-twp33bb6	137	7	virus	virus	NN
cord-018265-twp33bb6	137	8	can	can	MD
cord-018265-twp33bb6	137	9	evolve	evolve	VB
cord-018265-twp33bb6	137	10	into	into	IN
cord-018265-twp33bb6	137	11	the	the	DT
cord-018265-twp33bb6	137	12	early	early	JJ
cord-018265-twp33bb6	137	13	human	human	JJ
cord-018265-twp33bb6	137	14	SARS	SARS	NNP
cord-018265-twp33bb6	137	15	-	-	HYPH
cord-018265-twp33bb6	137	16	CoV	CoV	NNP
cord-018265-twp33bb6	137	17	,	,	,
cord-018265-twp33bb6	137	18	which	which	WDT
cord-018265-twp33bb6	137	19	has	have	VBZ
cord-018265-twp33bb6	137	20	the	the	DT
cord-018265-twp33bb6	137	21	ability	ability	NN
cord-018265-twp33bb6	137	22	to	to	TO
cord-018265-twp33bb6	137	23	be	be	VB
cord-018265-twp33bb6	137	24	transmitted	transmit	VBN
cord-018265-twp33bb6	137	25	from	from	IN
cord-018265-twp33bb6	137	26	animals	animal	NNS
cord-018265-twp33bb6	137	27	to	to	IN
cord-018265-twp33bb6	137	28	humans	human	NNS
cord-018265-twp33bb6	137	29	or	or	CC
cord-018265-twp33bb6	137	30	even	even	RB
cord-018265-twp33bb6	137	31	humans	human	NNS
cord-018265-twp33bb6	137	32	to	to	IN
cord-018265-twp33bb6	137	33	humans	human	NNS
cord-018265-twp33bb6	137	34	,	,	,
cord-018265-twp33bb6	137	35	thereby	thereby	RB
cord-018265-twp33bb6	137	36	leading	lead	VBG
cord-018265-twp33bb6	137	37	to	to	IN
cord-018265-twp33bb6	137	38	localized	localized	JJ
cord-018265-twp33bb6	137	39	outbreaks	outbreak	NNS
cord-018265-twp33bb6	137	40	of	of	IN
cord-018265-twp33bb6	137	41	mild	mild	JJ
cord-018265-twp33bb6	137	42	disease	disease	NN
cord-018265-twp33bb6	137	43	.	.	.
cord-018265-twp33bb6	138	1	The	the	DT
cord-018265-twp33bb6	138	2	early	early	JJ
cord-018265-twp33bb6	138	3	human	human	JJ
cord-018265-twp33bb6	138	4	SARS	SARS	NNP
cord-018265-twp33bb6	138	5	-	-	HYPH
cord-018265-twp33bb6	138	6	CoV	CoV	NNP
cord-018265-twp33bb6	138	7	,	,	,
cord-018265-twp33bb6	138	8	under	under	IN
cord-018265-twp33bb6	138	9	selective	selective	JJ
cord-018265-twp33bb6	138	10	pressure	pressure	NN
cord-018265-twp33bb6	138	11	in	in	IN
cord-018265-twp33bb6	138	12	humans	human	NNS
cord-018265-twp33bb6	138	13	,	,	,
cord-018265-twp33bb6	138	14	may	may	MD
cord-018265-twp33bb6	138	15	further	further	RB
cord-018265-twp33bb6	138	16	evolve	evolve	VB
cord-018265-twp33bb6	138	17	into	into	IN
cord-018265-twp33bb6	138	18	the	the	DT
cord-018265-twp33bb6	138	19	late	late	JJ
cord-018265-twp33bb6	138	20	human	human	JJ
cord-018265-twp33bb6	138	21	SARS	SARS	NNP
cord-018265-twp33bb6	138	22	-	-	HYPH
cord-018265-twp33bb6	138	23	CoV	CoV	NNP
cord-018265-twp33bb6	138	24	,	,	,
cord-018265-twp33bb6	138	25	which	which	WDT
cord-018265-twp33bb6	138	26	can	can	MD
cord-018265-twp33bb6	138	27	cause	cause	VB
cord-018265-twp33bb6	138	28	local	local	JJ
cord-018265-twp33bb6	138	29	or	or	CC
cord-018265-twp33bb6	138	30	global	global	JJ
cord-018265-twp33bb6	138	31	outbreaks	outbreak	NNS
cord-018265-twp33bb6	138	32	of	of	IN
cord-018265-twp33bb6	138	33	typical	typical	JJ
cord-018265-twp33bb6	138	34	SARS	SARS	NNP
cord-018265-twp33bb6	138	35	[	[	-LRB-
cord-018265-twp33bb6	138	36	39	39	CD
cord-018265-twp33bb6	138	37	]	]	-RRB-
cord-018265-twp33bb6	138	38	.	.	.
cord-018265-twp33bb6	139	1	SARS	SARS	NNP
cord-018265-twp33bb6	139	2	can	can	MD
cord-018265-twp33bb6	139	3	be	be	VB
cord-018265-twp33bb6	139	4	easily	easily	RB
cord-018265-twp33bb6	139	5	grown	grow	VBN
cord-018265-twp33bb6	139	6	in	in	IN
cord-018265-twp33bb6	139	7	cell	cell	NN
cord-018265-twp33bb6	139	8	cultures	culture	NNS
cord-018265-twp33bb6	139	9	[	[	-LRB-
cord-018265-twp33bb6	139	10	38	38	CD
cord-018265-twp33bb6	139	11	]	]	-RRB-
cord-018265-twp33bb6	139	12	.	.	.
cord-018265-twp33bb6	140	1	Thus	thus	RB
cord-018265-twp33bb6	140	2	,	,	,
cord-018265-twp33bb6	140	3	there	there	EX
cord-018265-twp33bb6	140	4	is	be	VBZ
cord-018265-twp33bb6	140	5	an	an	DT
cord-018265-twp33bb6	140	6	urgent	urgent	JJ
cord-018265-twp33bb6	140	7	need	need	NN
cord-018265-twp33bb6	140	8	for	for	IN
cord-018265-twp33bb6	140	9	vaccines	vaccine	NNS
cord-018265-twp33bb6	140	10	,	,	,
cord-018265-twp33bb6	140	11	not	not	RB
cord-018265-twp33bb6	140	12	only	only	RB
cord-018265-twp33bb6	140	13	to	to	TO
cord-018265-twp33bb6	140	14	prevent	prevent	VB
cord-018265-twp33bb6	140	15	naturally	naturally	RB
cord-018265-twp33bb6	140	16	occurring	occur	VBG
cord-018265-twp33bb6	140	17	epidemic	epidemic	NN
cord-018265-twp33bb6	140	18	outbreaks	outbreak	NNS
cord-018265-twp33bb6	140	19	,	,	,
cord-018265-twp33bb6	140	20	but	but	CC
cord-018265-twp33bb6	140	21	also	also	RB
cord-018265-twp33bb6	140	22	as	as	IN
cord-018265-twp33bb6	140	23	a	a	DT
cord-018265-twp33bb6	140	24	tool	tool	NN
cord-018265-twp33bb6	140	25	against	against	IN
cord-018265-twp33bb6	140	26	the	the	DT
cord-018265-twp33bb6	140	27	threat	threat	NN
cord-018265-twp33bb6	140	28	of	of	IN
cord-018265-twp33bb6	140	29	biological	biological	JJ
cord-018265-twp33bb6	140	30	weapons	weapon	NNS
cord-018265-twp33bb6	140	31	.	.	.
cord-018265-twp33bb6	141	1	Several	several	JJ
cord-018265-twp33bb6	141	2	structural	structural	JJ
cord-018265-twp33bb6	141	3	proteins	protein	NNS
cord-018265-twp33bb6	141	4	are	be	VBP
cord-018265-twp33bb6	141	5	expressed	express	VBN
cord-018265-twp33bb6	141	6	by	by	IN
cord-018265-twp33bb6	141	7	SARS	SARS	NNP
cord-018265-twp33bb6	141	8	-	-	HYPH
cord-018265-twp33bb6	141	9	CoV	CoV	NNP
cord-018265-twp33bb6	141	10	,	,	,
cord-018265-twp33bb6	141	11	including	include	VBG
cord-018265-twp33bb6	141	12	nucleocapsid	nucleocapsid	NN
cord-018265-twp33bb6	141	13	,	,	,
cord-018265-twp33bb6	141	14	envelope	envelope	NN
cord-018265-twp33bb6	141	15	and	and	CC
cord-018265-twp33bb6	141	16	spike	spike	NN
cord-018265-twp33bb6	141	17	(	(	-LRB-
cord-018265-twp33bb6	141	18	S	s	NN
cord-018265-twp33bb6	141	19	)	)	-RRB-
cord-018265-twp33bb6	141	20	proteins	protein	NNS
cord-018265-twp33bb6	141	21	[	[	-LRB-
cord-018265-twp33bb6	141	22	38	38	CD
cord-018265-twp33bb6	141	23	]	]	-RRB-
cord-018265-twp33bb6	141	24	.	.	.
cord-018265-twp33bb6	142	1	The	the	DT
cord-018265-twp33bb6	142	2	latter	latter	JJ
cord-018265-twp33bb6	142	3	is	be	VBZ
cord-018265-twp33bb6	142	4	a	a	DT
cord-018265-twp33bb6	142	5	type	type	NN
cord-018265-twp33bb6	142	6	I	-PRON-	PRP
cord-018265-twp33bb6	142	7	trans	trans	NN
cord-018265-twp33bb6	142	8	-	-	NN
cord-018265-twp33bb6	142	9	membrane	membrane	NN
cord-018265-twp33bb6	142	10	glycoprotein	glycoprotein	NN
cord-018265-twp33bb6	142	11	,	,	,
cord-018265-twp33bb6	142	12	which	which	WDT
cord-018265-twp33bb6	142	13	is	be	VBZ
cord-018265-twp33bb6	142	14	responsible	responsible	JJ
cord-018265-twp33bb6	142	15	for	for	IN
cord-018265-twp33bb6	142	16	virus	virus	NN
cord-018265-twp33bb6	142	17	binding	binding	NN
cord-018265-twp33bb6	142	18	,	,	,
cord-018265-twp33bb6	142	19	fusion	fusion	NN
cord-018265-twp33bb6	142	20	and	and	CC
cord-018265-twp33bb6	142	21	entry	entry	NN
cord-018265-twp33bb6	142	22	,	,	,
cord-018265-twp33bb6	142	23	and	and	CC
cord-018265-twp33bb6	142	24	being	be	VBG
cord-018265-twp33bb6	142	25	the	the	DT
cord-018265-twp33bb6	142	26	major	major	JJ
cord-018265-twp33bb6	142	27	target	target	NN
cord-018265-twp33bb6	142	28	of	of	IN
cord-018265-twp33bb6	142	29	neutralizing	neutralize	VBG
cord-018265-twp33bb6	142	30	antibodies	antibody	NNS
cord-018265-twp33bb6	142	31	[	[	-LRB-
cord-018265-twp33bb6	142	32	38	38	CD
cord-018265-twp33bb6	142	33	,	,	,
cord-018265-twp33bb6	142	34	40	40	CD
cord-018265-twp33bb6	142	35	]	]	-RRB-
cord-018265-twp33bb6	142	36	.	.	.
cord-018265-twp33bb6	143	1	The	the	DT
cord-018265-twp33bb6	143	2	extracelullar	extracelullar	JJ
cord-018265-twp33bb6	143	3	domain	domain	NN
cord-018265-twp33bb6	143	4	of	of	IN
cord-018265-twp33bb6	143	5	the	the	DT
cord-018265-twp33bb6	143	6	S	S	NNP
cord-018265-twp33bb6	143	7	protein	protein	NN
cord-018265-twp33bb6	143	8	consists	consist	VBZ
cord-018265-twp33bb6	143	9	of	of	IN
cord-018265-twp33bb6	143	10	two	two	CD
cord-018265-twp33bb6	143	11	subunits	subunit	NNS
cord-018265-twp33bb6	143	12	,	,	,
cord-018265-twp33bb6	143	13	S1	s1	NN
cord-018265-twp33bb6	143	14	and	and	CC
cord-018265-twp33bb6	143	15	S2	S2	NNP
cord-018265-twp33bb6	143	16	[	[	-LRB-
cord-018265-twp33bb6	143	17	40	40	CD
cord-018265-twp33bb6	143	18	]	]	-RRB-
cord-018265-twp33bb6	143	19	.	.	.
cord-018265-twp33bb6	144	1	The	the	DT
cord-018265-twp33bb6	144	2	S1	s1	NN
cord-018265-twp33bb6	144	3	subunit	subunit	NN
cord-018265-twp33bb6	144	4	possess	possess	VBP
cord-018265-twp33bb6	144	5	a	a	DT
cord-018265-twp33bb6	144	6	receptor	receptor	NN
cord-018265-twp33bb6	144	7	-	-	HYPH
cord-018265-twp33bb6	144	8	binding	bind	VBG
cord-018265-twp33bb6	144	9	domain	domain	NN
cord-018265-twp33bb6	144	10	(	(	-LRB-
cord-018265-twp33bb6	144	11	RBD	RBD	NNP
cord-018265-twp33bb6	144	12	)	)	-RRB-
cord-018265-twp33bb6	144	13	,	,	,
cord-018265-twp33bb6	144	14	which	which	WDT
cord-018265-twp33bb6	144	15	is	be	VBZ
cord-018265-twp33bb6	144	16	responsible	responsible	JJ
cord-018265-twp33bb6	144	17	for	for	IN
cord-018265-twp33bb6	144	18	viral	viral	JJ
cord-018265-twp33bb6	144	19	binding	binding	NN
cord-018265-twp33bb6	144	20	to	to	IN
cord-018265-twp33bb6	144	21	one	one	CD
cord-018265-twp33bb6	144	22	of	of	IN
cord-018265-twp33bb6	144	23	its	-PRON-	PRP$
cord-018265-twp33bb6	144	24	receptors	receptor	NNS
cord-018265-twp33bb6	144	25	[	[	-LRB-
cord-018265-twp33bb6	144	26	41	41	CD
cord-018265-twp33bb6	144	27	,	,	,
cord-018265-twp33bb6	144	28	42	42	CD
cord-018265-twp33bb6	144	29	]	]	-RRB-
cord-018265-twp33bb6	144	30	.	.	.
cord-018265-twp33bb6	145	1	Vector	vector	NN
cord-018265-twp33bb6	145	2	-	-	HYPH
cord-018265-twp33bb6	145	3	based	base	VBN
cord-018265-twp33bb6	145	4	vaccines	vaccine	NNS
cord-018265-twp33bb6	145	5	expressing	express	VBG
cord-018265-twp33bb6	145	6	the	the	DT
cord-018265-twp33bb6	145	7	S	S	NNP
cord-018265-twp33bb6	145	8	protein	protein	NN
cord-018265-twp33bb6	145	9	,	,	,
cord-018265-twp33bb6	145	10	as	as	RB
cord-018265-twp33bb6	145	11	well	well	RB
cord-018265-twp33bb6	145	12	as	as	IN
cord-018265-twp33bb6	145	13	DNA	dna	NN
cord-018265-twp33bb6	145	14	vaccines	vaccine	NNS
cord-018265-twp33bb6	145	15	encoding	encode	VBG
cord-018265-twp33bb6	145	16	full	full	JJ
cord-018265-twp33bb6	145	17	-	-	HYPH
cord-018265-twp33bb6	145	18	length	length	NN
cord-018265-twp33bb6	145	19	S	s	NN
cord-018265-twp33bb6	145	20	protein	protein	NN
cord-018265-twp33bb6	145	21	have	have	VBP
cord-018265-twp33bb6	145	22	been	be	VBN
cord-018265-twp33bb6	145	23	assessed	assess	VBN
cord-018265-twp33bb6	145	24	in	in	IN
cord-018265-twp33bb6	145	25	preclinical	preclinical	JJ
cord-018265-twp33bb6	145	26	studies	study	NNS
cord-018265-twp33bb6	145	27	[	[	-LRB-
cord-018265-twp33bb6	145	28	43	43	CD
cord-018265-twp33bb6	145	29	,	,	,
cord-018265-twp33bb6	145	30	44	44	CD
cord-018265-twp33bb6	145	31	]	]	-RRB-
cord-018265-twp33bb6	145	32	.	.	.
cord-018265-twp33bb6	146	1	When	when	WRB
cord-018265-twp33bb6	146	2	modified	modify	VBN
cord-018265-twp33bb6	146	3	vaccinia	vaccinia	NN
cord-018265-twp33bb6	146	4	virus	virus	NN
cord-018265-twp33bb6	146	5	Ankara	Ankara	NNP
cord-018265-twp33bb6	146	6	(	(	-LRB-
cord-018265-twp33bb6	146	7	MVA	MVA	NNP
cord-018265-twp33bb6	146	8	)	)	-RRB-
cord-018265-twp33bb6	146	9	coding	code	VBG
cord-018265-twp33bb6	146	10	for	for	IN
cord-018265-twp33bb6	146	11	full	full	JJ
cord-018265-twp33bb6	146	12	-	-	HYPH
cord-018265-twp33bb6	146	13	length	length	NN
cord-018265-twp33bb6	146	14	S	s	NN
cord-018265-twp33bb6	146	15	protein	protein	NN
cord-018265-twp33bb6	146	16	was	be	VBD
cord-018265-twp33bb6	146	17	administered	administer	VBN
cord-018265-twp33bb6	146	18	by	by	IN
cord-018265-twp33bb6	146	19	either	either	DT
cord-018265-twp33bb6	146	20	intranasal	intranasal	JJ
cord-018265-twp33bb6	146	21	or	or	CC
cord-018265-twp33bb6	146	22	intramuscular	intramuscular	JJ
cord-018265-twp33bb6	146	23	route	route	NN
cord-018265-twp33bb6	146	24	,	,	,
cord-018265-twp33bb6	146	25	neutralizing	neutralize	VBG
cord-018265-twp33bb6	146	26	antibodies	antibody	NNS
cord-018265-twp33bb6	146	27	were	be	VBD
cord-018265-twp33bb6	146	28	elicited	elicit	VBN
cord-018265-twp33bb6	146	29	[	[	-LRB-
cord-018265-twp33bb6	146	30	45	45	CD
cord-018265-twp33bb6	146	31	]	]	-RRB-
cord-018265-twp33bb6	146	32	.	.	.
cord-018265-twp33bb6	147	1	However	however	RB
cord-018265-twp33bb6	147	2	,	,	,
cord-018265-twp33bb6	147	3	vaccination	vaccination	NN
cord-018265-twp33bb6	147	4	of	of	IN
cord-018265-twp33bb6	147	5	ferrets	ferret	NNS
cord-018265-twp33bb6	147	6	resulted	result	VBD
cord-018265-twp33bb6	147	7	in	in	IN
cord-018265-twp33bb6	147	8	liver	liver	NN
cord-018265-twp33bb6	147	9	damage	damage	NN
cord-018265-twp33bb6	147	10	after	after	IN
cord-018265-twp33bb6	147	11	challenge	challenge	NN
cord-018265-twp33bb6	147	12	,	,	,
cord-018265-twp33bb6	147	13	raising	raise	VBG
cord-018265-twp33bb6	147	14	some	some	DT
cord-018265-twp33bb6	147	15	concerns	concern	NNS
cord-018265-twp33bb6	147	16	about	about	IN
cord-018265-twp33bb6	147	17	the	the	DT
cord-018265-twp33bb6	147	18	safety	safety	NN
cord-018265-twp33bb6	147	19	of	of	IN
cord-018265-twp33bb6	147	20	this	this	DT
cord-018265-twp33bb6	147	21	approach	approach	NN
cord-018265-twp33bb6	147	22	[	[	-LRB-
cord-018265-twp33bb6	147	23	46	46	CD
cord-018265-twp33bb6	147	24	]	]	-RRB-
cord-018265-twp33bb6	147	25	.	.	.
cord-018265-twp33bb6	148	1	Vaccines	vaccine	NNS
cord-018265-twp33bb6	148	2	formulated	formulate	VBN
cord-018265-twp33bb6	148	3	using	use	VBG
cord-018265-twp33bb6	148	4	different	different	JJ
cord-018265-twp33bb6	148	5	synthetic	synthetic	JJ
cord-018265-twp33bb6	148	6	peptides	peptide	NNS
cord-018265-twp33bb6	148	7	encompassing	encompass	VBG
cord-018265-twp33bb6	148	8	linear	linear	NNP
cord-018265-twp33bb6	148	9	B	B	NNP
cord-018265-twp33bb6	148	10	cell	cell	NN
cord-018265-twp33bb6	148	11	epitopes	epitope	NNS
cord-018265-twp33bb6	148	12	from	from	IN
cord-018265-twp33bb6	148	13	the	the	DT
cord-018265-twp33bb6	148	14	S	S	NNP
cord-018265-twp33bb6	148	15	protein	protein	NN
cord-018265-twp33bb6	148	16	,	,	,
cord-018265-twp33bb6	148	17	which	which	WDT
cord-018265-twp33bb6	148	18	were	be	VBD
cord-018265-twp33bb6	148	19	identified	identify	VBN
cord-018265-twp33bb6	148	20	using	use	VBG
cord-018265-twp33bb6	148	21	sera	sera	NNP
cord-018265-twp33bb6	148	22	from	from	IN
cord-018265-twp33bb6	148	23	convalescent	convalescent	JJ
cord-018265-twp33bb6	148	24	patients	patient	NNS
cord-018265-twp33bb6	148	25	,	,	,
cord-018265-twp33bb6	148	26	stimulated	stimulate	VBD
cord-018265-twp33bb6	148	27	high	high	JJ
cord-018265-twp33bb6	148	28	antibody	antibody	NN
cord-018265-twp33bb6	148	29	titres	titre	NNS
cord-018265-twp33bb6	148	30	.	.	.
cord-018265-twp33bb6	149	1	Nevertheless	nevertheless	RB
cord-018265-twp33bb6	149	2	,	,	,
cord-018265-twp33bb6	149	3	none	none	NN
cord-018265-twp33bb6	149	4	of	of	IN
cord-018265-twp33bb6	149	5	them	-PRON-	PRP
cord-018265-twp33bb6	149	6	triggered	trigger	VBD
cord-018265-twp33bb6	149	7	the	the	DT
cord-018265-twp33bb6	149	8	elicitation	elicitation	NN
cord-018265-twp33bb6	149	9	of	of	IN
cord-018265-twp33bb6	149	10	neutralizing	neutralize	VBG
cord-018265-twp33bb6	149	11	activity	activity	NN
cord-018265-twp33bb6	149	12	.	.	.
cord-018265-twp33bb6	150	1	On	on	IN
cord-018265-twp33bb6	150	2	the	the	DT
cord-018265-twp33bb6	150	3	other	other	JJ
cord-018265-twp33bb6	150	4	hand	hand	NN
cord-018265-twp33bb6	150	5	,	,	,
cord-018265-twp33bb6	150	6	some	some	DT
cord-018265-twp33bb6	150	7	studies	study	NNS
cord-018265-twp33bb6	150	8	demonstrated	demonstrate	VBD
cord-018265-twp33bb6	150	9	that	that	IN
cord-018265-twp33bb6	150	10	although	although	IN
cord-018265-twp33bb6	150	11	antibodies	antibody	NNS
cord-018265-twp33bb6	150	12	against	against	IN
cord-018265-twp33bb6	150	13	S	S	NNP
cord-018265-twp33bb6	150	14	protein	protein	NN
cord-018265-twp33bb6	150	15	of	of	IN
cord-018265-twp33bb6	150	16	the	the	DT
cord-018265-twp33bb6	150	17	late	late	JJ
cord-018265-twp33bb6	150	18	SARS	SARS	NNP
cord-018265-twp33bb6	150	19	-	-	HYPH
cord-018265-twp33bb6	150	20	CoV	CoV	NNP
cord-018265-twp33bb6	150	21	(	(	-LRB-
cord-018265-twp33bb6	150	22	Urbani	Urbani	NNP
cord-018265-twp33bb6	150	23	strain	strain	NN
cord-018265-twp33bb6	150	24	)	)	-RRB-
cord-018265-twp33bb6	151	1	exhibit	exhibit	NN
cord-018265-twp33bb6	151	2	neutralizing	neutralize	VBG
cord-018265-twp33bb6	151	3	activity	activity	NN
cord-018265-twp33bb6	151	4	,	,	,
cord-018265-twp33bb6	151	5	they	-PRON-	PRP
cord-018265-twp33bb6	151	6	can	can	MD
cord-018265-twp33bb6	151	7	also	also	RB
cord-018265-twp33bb6	151	8	enhance	enhance	VB
cord-018265-twp33bb6	151	9	infection	infection	NN
cord-018265-twp33bb6	151	10	by	by	IN
cord-018265-twp33bb6	151	11	an	an	DT
cord-018265-twp33bb6	151	12	early	early	JJ
cord-018265-twp33bb6	151	13	human	human	JJ
cord-018265-twp33bb6	151	14	SARS	SARS	NNP
cord-018265-twp33bb6	151	15	-	-	HYPH
cord-018265-twp33bb6	151	16	CoV	CoV	NNP
cord-018265-twp33bb6	151	17	isolate	isolate	NN
cord-018265-twp33bb6	151	18	(	(	-LRB-
cord-018265-twp33bb6	151	19	GD03T0013	GD03T0013	NNP
cord-018265-twp33bb6	151	20	)	)	-RRB-
cord-018265-twp33bb6	151	21	and	and	CC
cord-018265-twp33bb6	151	22	the	the	DT
cord-018265-twp33bb6	151	23	civet	civet	NN
cord-018265-twp33bb6	151	24	SARS	SARS	NNP
cord-018265-twp33bb6	151	25	-	-	HYPH
cord-018265-twp33bb6	151	26	CoV	CoV	NNP
cord-018265-twp33bb6	151	27	-	-	HYPH
cord-018265-twp33bb6	151	28	like	like	JJ
cord-018265-twp33bb6	151	29	viruses	virus	NNS
cord-018265-twp33bb6	151	30	.	.	.
cord-018265-twp33bb6	152	1	A	a	DT
cord-018265-twp33bb6	152	2	derivative	derivative	NN
cord-018265-twp33bb6	152	3	of	of	IN
cord-018265-twp33bb6	152	4	the	the	DT
cord-018265-twp33bb6	152	5	S	S	NNP
cord-018265-twp33bb6	152	6	protein	protein	NN
cord-018265-twp33bb6	152	7	with	with	IN
cord-018265-twp33bb6	152	8	a	a	DT
cord-018265-twp33bb6	152	9	truncation	truncation	NN
cord-018265-twp33bb6	152	10	at	at	IN
cord-018265-twp33bb6	152	11	amino	amino	NN
cord-018265-twp33bb6	152	12	acid	acid	NN
cord-018265-twp33bb6	152	13	(	(	-LRB-
cord-018265-twp33bb6	152	14	aa	aa	NNP
cord-018265-twp33bb6	152	15	)	)	-RRB-
cord-018265-twp33bb6	152	16	1153	1153	CD
cord-018265-twp33bb6	152	17	fails	fail	VBZ
cord-018265-twp33bb6	152	18	to	to	TO
cord-018265-twp33bb6	152	19	cause	cause	VB
cord-018265-twp33bb6	152	20	antibody	antibody	NN
cord-018265-twp33bb6	152	21	dependent	dependent	JJ
cord-018265-twp33bb6	152	22	enhancement	enhancement	NN
cord-018265-twp33bb6	152	23	of	of	IN
cord-018265-twp33bb6	152	24	infection	infection	NN
cord-018265-twp33bb6	152	25	,	,	,
cord-018265-twp33bb6	152	26	but	but	CC
cord-018265-twp33bb6	152	27	retains	retain	VBZ
cord-018265-twp33bb6	152	28	the	the	DT
cord-018265-twp33bb6	152	29	ability	ability	NN
cord-018265-twp33bb6	152	30	to	to	TO
cord-018265-twp33bb6	152	31	induce	induce	VB
cord-018265-twp33bb6	152	32	neutralizing	neutralize	VBG
cord-018265-twp33bb6	152	33	antibodies	antibody	NNS
cord-018265-twp33bb6	152	34	.	.	.
cord-018265-twp33bb6	153	1	These	these	DT
cord-018265-twp33bb6	153	2	findings	finding	NNS
cord-018265-twp33bb6	153	3	suggest	suggest	VBP
cord-018265-twp33bb6	153	4	that	that	IN
cord-018265-twp33bb6	153	5	the	the	DT
cord-018265-twp33bb6	153	6	elimination	elimination	NN
cord-018265-twp33bb6	153	7	of	of	IN
cord-018265-twp33bb6	153	8	the	the	DT
cord-018265-twp33bb6	153	9	putative	putative	JJ
cord-018265-twp33bb6	153	10	heptad	heptad	NN
cord-018265-twp33bb6	153	11	repeated	repeat	VBN
cord-018265-twp33bb6	153	12	2	2	CD
cord-018265-twp33bb6	153	13	(	(	-LRB-
cord-018265-twp33bb6	153	14	HR2	HR2	NNP
cord-018265-twp33bb6	153	15	,	,	,
cord-018265-twp33bb6	153	16	aa	aa	NNP
cord-018265-twp33bb6	153	17	1153	1153	CD
cord-018265-twp33bb6	153	18	-	-	HYPH
cord-018265-twp33bb6	153	19	1194	1194	CD
cord-018265-twp33bb6	153	20	)	)	-RRB-
cord-018265-twp33bb6	153	21	,	,	,
cord-018265-twp33bb6	153	22	which	which	WDT
cord-018265-twp33bb6	153	23	is	be	VBZ
cord-018265-twp33bb6	153	24	implicated	implicate	VBN
cord-018265-twp33bb6	153	25	in	in	IN
cord-018265-twp33bb6	153	26	viral	viral	JJ
cord-018265-twp33bb6	153	27	fusion	fusion	NN
cord-018265-twp33bb6	153	28	,	,	,
cord-018265-twp33bb6	153	29	might	may	MD
cord-018265-twp33bb6	153	30	abrogate	abrogate	VB
cord-018265-twp33bb6	153	31	the	the	DT
cord-018265-twp33bb6	153	32	stimulation	stimulation	NN
cord-018265-twp33bb6	153	33	of	of	IN
cord-018265-twp33bb6	153	34	virus	virus	NN
cord-018265-twp33bb6	153	35	infection	infection	NN
cord-018265-twp33bb6	153	36	-	-	HYPH
cord-018265-twp33bb6	153	37	enhancing	enhance	VBG
cord-018265-twp33bb6	153	38	antibodies	antibody	NNS
cord-018265-twp33bb6	153	39	[	[	-LRB-
cord-018265-twp33bb6	153	40	47	47	CD
cord-018265-twp33bb6	153	41	,	,	,
cord-018265-twp33bb6	153	42	48	48	CD
cord-018265-twp33bb6	153	43	]	]	-RRB-
cord-018265-twp33bb6	153	44	.	.	.
cord-018265-twp33bb6	154	1	The	the	DT
cord-018265-twp33bb6	154	2	use	use	NN
cord-018265-twp33bb6	154	3	of	of	IN
cord-018265-twp33bb6	154	4	the	the	DT
cord-018265-twp33bb6	154	5	nucleoprotein	nucleoprotein	NN
cord-018265-twp33bb6	154	6	of	of	IN
cord-018265-twp33bb6	154	7	the	the	DT
cord-018265-twp33bb6	154	8	coronavirus	coronavirus	NN
cord-018265-twp33bb6	154	9	in	in	IN
cord-018265-twp33bb6	154	10	a	a	DT
cord-018265-twp33bb6	154	11	DNA	dna	NN
cord-018265-twp33bb6	154	12	vaccination	vaccination	NN
cord-018265-twp33bb6	154	13	protocol	protocol	NN
cord-018265-twp33bb6	154	14	also	also	RB
cord-018265-twp33bb6	154	15	led	lead	VBD
cord-018265-twp33bb6	154	16	to	to	IN
cord-018265-twp33bb6	154	17	the	the	DT
cord-018265-twp33bb6	154	18	stimulation	stimulation	NN
cord-018265-twp33bb6	154	19	of	of	IN
cord-018265-twp33bb6	154	20	a	a	DT
cord-018265-twp33bb6	154	21	protective	protective	JJ
cord-018265-twp33bb6	154	22	response	response	NN
cord-018265-twp33bb6	154	23	[	[	-LRB-
cord-018265-twp33bb6	154	24	49	49	CD
cord-018265-twp33bb6	154	25	]	]	-RRB-
cord-018265-twp33bb6	154	26	.	.	.
cord-018265-twp33bb6	155	1	In	in	IN
cord-018265-twp33bb6	155	2	contrast	contrast	NN
cord-018265-twp33bb6	155	3	,	,	,
cord-018265-twp33bb6	155	4	protection	protection	NN
cord-018265-twp33bb6	155	5	was	be	VBD
cord-018265-twp33bb6	155	6	not	not	RB
cord-018265-twp33bb6	155	7	achieved	achieve	VBN
cord-018265-twp33bb6	155	8	when	when	WRB
cord-018265-twp33bb6	155	9	a	a	DT
cord-018265-twp33bb6	155	10	recombinant	recombinant	JJ
cord-018265-twp33bb6	155	11	PIV-3	PIV-3	NNP
cord-018265-twp33bb6	155	12	expressing	express	VBG
cord-018265-twp33bb6	155	13	the	the	DT
cord-018265-twp33bb6	155	14	nucleoprotein	nucleoprotein	NNP
cord-018265-twp33bb6	155	15	alone	alone	RB
cord-018265-twp33bb6	155	16	or	or	CC
cord-018265-twp33bb6	155	17	together	together	RB
cord-018265-twp33bb6	155	18	with	with	IN
cord-018265-twp33bb6	155	19	the	the	DT
cord-018265-twp33bb6	155	20	matrix	matrix	NN
cord-018265-twp33bb6	155	21	protein	protein	NN
cord-018265-twp33bb6	155	22	was	be	VBD
cord-018265-twp33bb6	155	23	used	use	VBN
cord-018265-twp33bb6	155	24	[	[	-LRB-
cord-018265-twp33bb6	155	25	50	50	CD
cord-018265-twp33bb6	155	26	]	]	-RRB-
cord-018265-twp33bb6	155	27	.	.	.
cord-018265-twp33bb6	156	1	This	this	DT
cord-018265-twp33bb6	156	2	demonstrates	demonstrate	VBZ
cord-018265-twp33bb6	156	3	that	that	IN
cord-018265-twp33bb6	156	4	the	the	DT
cord-018265-twp33bb6	156	5	selection	selection	NN
cord-018265-twp33bb6	156	6	of	of	IN
cord-018265-twp33bb6	156	7	the	the	DT
cord-018265-twp33bb6	156	8	delivery	delivery	NN
cord-018265-twp33bb6	156	9	system	system	NN
cord-018265-twp33bb6	156	10	and	and	CC
cord-018265-twp33bb6	156	11	immunization	immunization	NN
cord-018265-twp33bb6	156	12	strategy	strategy	NN
cord-018265-twp33bb6	156	13	play	play	VBP
cord-018265-twp33bb6	156	14	a	a	DT
cord-018265-twp33bb6	156	15	critical	critical	JJ
cord-018265-twp33bb6	156	16	role	role	NN
cord-018265-twp33bb6	156	17	in	in	IN
cord-018265-twp33bb6	156	18	vaccine	vaccine	NN
cord-018265-twp33bb6	156	19	efficacy	efficacy	NN
cord-018265-twp33bb6	156	20	.	.	.
cord-018265-twp33bb6	157	1	The	the	DT
cord-018265-twp33bb6	157	2	human	human	JJ
cord-018265-twp33bb6	157	3	adenoviruses	adenovirus	NNS
cord-018265-twp33bb6	157	4	are	be	VBP
cord-018265-twp33bb6	157	5	divided	divide	VBN
cord-018265-twp33bb6	157	6	into	into	IN
cord-018265-twp33bb6	157	7	six	six	CD
cord-018265-twp33bb6	157	8	subgroups	subgroup	NNS
cord-018265-twp33bb6	157	9	(	(	-LRB-
cord-018265-twp33bb6	157	10	A	A	NNP
cord-018265-twp33bb6	157	11	-	-	HYPH
cord-018265-twp33bb6	157	12	F	F	NNP
cord-018265-twp33bb6	157	13	)	)	-RRB-
cord-018265-twp33bb6	157	14	.	.	.
cord-018265-twp33bb6	158	1	The	the	DT
cord-018265-twp33bb6	158	2	adenovirus	adenovirus	NN
cord-018265-twp33bb6	158	3	can	can	MD
cord-018265-twp33bb6	158	4	cause	cause	VB
cord-018265-twp33bb6	158	5	large	large	JJ
cord-018265-twp33bb6	158	6	-	-	HYPH
cord-018265-twp33bb6	158	7	scale	scale	NN
cord-018265-twp33bb6	158	8	epidemics	epidemic	NNS
cord-018265-twp33bb6	158	9	of	of	IN
cord-018265-twp33bb6	158	10	acute	acute	JJ
cord-018265-twp33bb6	158	11	respiratory	respiratory	JJ
cord-018265-twp33bb6	158	12	disease	disease	NN
cord-018265-twp33bb6	158	13	,	,	,
cord-018265-twp33bb6	158	14	and	and	CC
cord-018265-twp33bb6	158	15	dissemination	dissemination	NN
cord-018265-twp33bb6	158	16	is	be	VBZ
cord-018265-twp33bb6	158	17	especially	especially	RB
cord-018265-twp33bb6	158	18	favoured	favour	VBN
cord-018265-twp33bb6	158	19	under	under	IN
cord-018265-twp33bb6	158	20	conditions	condition	NNS
cord-018265-twp33bb6	158	21	in	in	IN
cord-018265-twp33bb6	158	22	which	which	WDT
cord-018265-twp33bb6	158	23	persons	person	NNS
cord-018265-twp33bb6	158	24	are	be	VBP
cord-018265-twp33bb6	158	25	housed	house	VBN
cord-018265-twp33bb6	158	26	communally	communally	RB
cord-018265-twp33bb6	158	27	.	.	.
cord-018265-twp33bb6	159	1	The	the	DT
cord-018265-twp33bb6	159	2	subgroup	subgroup	NN
cord-018265-twp33bb6	159	3	A	a	DT
cord-018265-twp33bb6	159	4	viruses	virus	NNS
cord-018265-twp33bb6	159	5	,	,	,
cord-018265-twp33bb6	159	6	such	such	JJ
cord-018265-twp33bb6	159	7	as	as	IN
cord-018265-twp33bb6	159	8	Ad31	ad31	CD
cord-018265-twp33bb6	159	9	,	,	,
cord-018265-twp33bb6	159	10	have	have	VBP
cord-018265-twp33bb6	159	11	been	be	VBN
cord-018265-twp33bb6	159	12	associated	associate	VBN
cord-018265-twp33bb6	159	13	with	with	IN
cord-018265-twp33bb6	159	14	pneumonia	pneumonia	NN
cord-018265-twp33bb6	159	15	in	in	IN
cord-018265-twp33bb6	159	16	immunocompromised	immunocompromised	JJ
cord-018265-twp33bb6	159	17	patients	patient	NNS
cord-018265-twp33bb6	159	18	.	.	.
cord-018265-twp33bb6	160	1	Neutralizing	neutralize	VBG
cord-018265-twp33bb6	160	2	antibodies	antibody	NNS
cord-018265-twp33bb6	160	3	directed	direct	VBN
cord-018265-twp33bb6	160	4	against	against	IN
cord-018265-twp33bb6	160	5	the	the	DT
cord-018265-twp33bb6	160	6	capsid	capsid	NN
cord-018265-twp33bb6	160	7	(	(	-LRB-
cord-018265-twp33bb6	160	8	hexon	hexon	NN
cord-018265-twp33bb6	160	9	and	and	CC
cord-018265-twp33bb6	160	10	fiber	fiber	NN
cord-018265-twp33bb6	160	11	proteins	protein	NNS
cord-018265-twp33bb6	160	12	)	)	-RRB-
cord-018265-twp33bb6	160	13	seems	seem	VBZ
cord-018265-twp33bb6	160	14	to	to	TO
cord-018265-twp33bb6	160	15	be	be	VB
cord-018265-twp33bb6	160	16	the	the	DT
cord-018265-twp33bb6	160	17	main	main	JJ
cord-018265-twp33bb6	160	18	effector	effector	NN
cord-018265-twp33bb6	160	19	mechanism	mechanism	NN
cord-018265-twp33bb6	160	20	to	to	TO
cord-018265-twp33bb6	160	21	prevent	prevent	VB
cord-018265-twp33bb6	160	22	re	re	NNS
cord-018265-twp33bb6	160	23	-	-	NNS
cord-018265-twp33bb6	160	24	infections	infection	NNS
cord-018265-twp33bb6	160	25	by	by	IN
cord-018265-twp33bb6	160	26	adenovirus	adenovirus	NN
cord-018265-twp33bb6	160	27	[	[	-LRB-
cord-018265-twp33bb6	160	28	3	3	CD
cord-018265-twp33bb6	160	29	]	]	-RRB-
cord-018265-twp33bb6	160	30	.	.	.
cord-018265-twp33bb6	161	1	Until	until	IN
cord-018265-twp33bb6	161	2	1998	1998	CD
cord-018265-twp33bb6	161	3	,	,	,
cord-018265-twp33bb6	161	4	military	military	JJ
cord-018265-twp33bb6	161	5	recruits	recruit	NNS
cord-018265-twp33bb6	161	6	in	in	IN
cord-018265-twp33bb6	161	7	USA	USA	NNP
cord-018265-twp33bb6	161	8	were	be	VBD
cord-018265-twp33bb6	161	9	administered	administer	VBN
cord-018265-twp33bb6	161	10	enteric	enteric	JJ
cord-018265-twp33bb6	161	11	-	-	HYPH
cord-018265-twp33bb6	161	12	coated	coat	VBN
cord-018265-twp33bb6	161	13	capsules	capsule	NNS
cord-018265-twp33bb6	161	14	containing	contain	VBG
cord-018265-twp33bb6	161	15	live	live	JJ
cord-018265-twp33bb6	161	16	viruses	virus	NNS
cord-018265-twp33bb6	161	17	from	from	IN
cord-018265-twp33bb6	161	18	the	the	DT
cord-018265-twp33bb6	161	19	serotypes	serotype	NNS
cord-018265-twp33bb6	161	20	4	4	CD
cord-018265-twp33bb6	161	21	and	and	CC
cord-018265-twp33bb6	161	22	7	7	CD
cord-018265-twp33bb6	161	23	.	.	.
cord-018265-twp33bb6	162	1	The	the	DT
cord-018265-twp33bb6	162	2	virus	virus	NN
cord-018265-twp33bb6	162	3	,	,	,
cord-018265-twp33bb6	162	4	which	which	WDT
cord-018265-twp33bb6	162	5	was	be	VBD
cord-018265-twp33bb6	162	6	not	not	RB
cord-018265-twp33bb6	162	7	attenuated	attenuate	VBN
cord-018265-twp33bb6	162	8	if	if	IN
cord-018265-twp33bb6	162	9	delivered	deliver	VBN
cord-018265-twp33bb6	162	10	by	by	IN
cord-018265-twp33bb6	162	11	respiratory	respiratory	JJ
cord-018265-twp33bb6	162	12	route	route	NN
cord-018265-twp33bb6	162	13	,	,	,
cord-018265-twp33bb6	162	14	was	be	VBD
cord-018265-twp33bb6	162	15	able	able	JJ
cord-018265-twp33bb6	162	16	to	to	TO
cord-018265-twp33bb6	162	17	replicate	replicate	VB
cord-018265-twp33bb6	162	18	in	in	IN
cord-018265-twp33bb6	162	19	the	the	DT
cord-018265-twp33bb6	162	20	gastrointestinal	gastrointestinal	JJ
cord-018265-twp33bb6	162	21	tract	tract	NN
cord-018265-twp33bb6	162	22	without	without	IN
cord-018265-twp33bb6	162	23	causing	cause	VBG
cord-018265-twp33bb6	162	24	disease	disease	NN
cord-018265-twp33bb6	162	25	,	,	,
cord-018265-twp33bb6	162	26	thereby	thereby	RB
cord-018265-twp33bb6	162	27	stimulating	stimulate	VBG
cord-018265-twp33bb6	162	28	protective	protective	JJ
cord-018265-twp33bb6	162	29	responses	response	NNS
cord-018265-twp33bb6	162	30	in	in	IN
cord-018265-twp33bb6	162	31	the	the	DT
cord-018265-twp33bb6	162	32	respiratory	respiratory	JJ
cord-018265-twp33bb6	162	33	tract	tract	NN
cord-018265-twp33bb6	162	34	[	[	-LRB-
cord-018265-twp33bb6	162	35	51	51	CD
cord-018265-twp33bb6	162	36	]	]	-RRB-
cord-018265-twp33bb6	162	37	.	.	.
cord-018265-twp33bb6	163	1	When	when	WRB
cord-018265-twp33bb6	163	2	the	the	DT
cord-018265-twp33bb6	163	3	vaccine	vaccine	NN
cord-018265-twp33bb6	163	4	went	go	VBD
cord-018265-twp33bb6	163	5	out	out	IN
cord-018265-twp33bb6	163	6	of	of	IN
cord-018265-twp33bb6	163	7	production	production	NN
cord-018265-twp33bb6	163	8	,	,	,
cord-018265-twp33bb6	163	9	outbreaks	outbreak	NNS
cord-018265-twp33bb6	163	10	of	of	IN
cord-018265-twp33bb6	163	11	respiratory	respiratory	JJ
cord-018265-twp33bb6	163	12	diseases	disease	NNS
cord-018265-twp33bb6	163	13	caused	cause	VBN
cord-018265-twp33bb6	163	14	by	by	IN
cord-018265-twp33bb6	163	15	adenovirus	adenovirus	NN
cord-018265-twp33bb6	163	16	reemerged	reemerge	VBD
cord-018265-twp33bb6	163	17	among	among	IN
cord-018265-twp33bb6	163	18	the	the	DT
cord-018265-twp33bb6	163	19	military	military	JJ
cord-018265-twp33bb6	163	20	recruits	recruit	NNS
cord-018265-twp33bb6	163	21	[	[	-LRB-
cord-018265-twp33bb6	163	22	3	3	CD
cord-018265-twp33bb6	163	23	]	]	-RRB-
cord-018265-twp33bb6	163	24	.	.	.
cord-018265-twp33bb6	164	1	Since	since	IN
cord-018265-twp33bb6	164	2	serotypes	serotype	NNS
cord-018265-twp33bb6	164	3	1	1	CD
cord-018265-twp33bb6	164	4	,	,	,
cord-018265-twp33bb6	164	5	2	2	CD
cord-018265-twp33bb6	164	6	,	,	,
cord-018265-twp33bb6	164	7	3	3	CD
cord-018265-twp33bb6	164	8	and	and	CC
cord-018265-twp33bb6	164	9	5	5	CD
cord-018265-twp33bb6	164	10	cause	cause	VB
cord-018265-twp33bb6	164	11	the	the	DT
cord-018265-twp33bb6	164	12	80	80	CD
cord-018265-twp33bb6	164	13	%	%	NN
cord-018265-twp33bb6	164	14	of	of	IN
cord-018265-twp33bb6	164	15	adenovirus	adenovirus	NN
cord-018265-twp33bb6	164	16	associated	associate	VBN
cord-018265-twp33bb6	164	17	respiratory	respiratory	JJ
cord-018265-twp33bb6	164	18	disease	disease	NN
cord-018265-twp33bb6	164	19	in	in	IN
cord-018265-twp33bb6	164	20	young	young	JJ
cord-018265-twp33bb6	164	21	children	child	NNS
cord-018265-twp33bb6	164	22	,	,	,
cord-018265-twp33bb6	164	23	the	the	DT
cord-018265-twp33bb6	164	24	development	development	NN
cord-018265-twp33bb6	164	25	of	of	IN
cord-018265-twp33bb6	164	26	a	a	DT
cord-018265-twp33bb6	164	27	tetravalent	tetravalent	NN
cord-018265-twp33bb6	164	28	vaccine	vaccine	NN
cord-018265-twp33bb6	164	29	similar	similar	JJ
cord-018265-twp33bb6	164	30	to	to	IN
cord-018265-twp33bb6	164	31	the	the	DT
cord-018265-twp33bb6	164	32	above	above	RB
cord-018265-twp33bb6	164	33	mentioned	mention	VBN
cord-018265-twp33bb6	164	34	might	may	MD
cord-018265-twp33bb6	164	35	solve	solve	VB
cord-018265-twp33bb6	164	36	the	the	DT
cord-018265-twp33bb6	164	37	problem	problem	NN
cord-018265-twp33bb6	164	38	in	in	IN
cord-018265-twp33bb6	164	39	children	child	NNS
cord-018265-twp33bb6	164	40	[	[	-LRB-
cord-018265-twp33bb6	164	41	52	52	CD
cord-018265-twp33bb6	164	42	]	]	-RRB-
cord-018265-twp33bb6	164	43	.	.	.
cord-018265-twp33bb6	165	1	However	however	RB
cord-018265-twp33bb6	165	2	,	,	,
cord-018265-twp33bb6	165	3	the	the	DT
cord-018265-twp33bb6	165	4	implementation	implementation	NN
cord-018265-twp33bb6	165	5	of	of	IN
cord-018265-twp33bb6	165	6	a	a	DT
cord-018265-twp33bb6	165	7	vaccine	vaccine	NN
cord-018265-twp33bb6	165	8	(	(	-LRB-
cord-018265-twp33bb6	165	9	live	live	VB
cord-018265-twp33bb6	165	10	or	or	CC
cord-018265-twp33bb6	165	11	attenuated	attenuate	VBN
cord-018265-twp33bb6	165	12	)	)	-RRB-
cord-018265-twp33bb6	165	13	against	against	IN
cord-018265-twp33bb6	165	14	adenovirus	adenovirus	NN
cord-018265-twp33bb6	165	15	should	should	MD
cord-018265-twp33bb6	165	16	be	be	VB
cord-018265-twp33bb6	165	17	carefully	carefully	RB
cord-018265-twp33bb6	165	18	evaluated	evaluate	VBN
cord-018265-twp33bb6	165	19	,	,	,
cord-018265-twp33bb6	165	20	since	since	IN
cord-018265-twp33bb6	165	21	recombinant	recombinant	JJ
cord-018265-twp33bb6	165	22	adenoviruses	adenovirus	NNS
cord-018265-twp33bb6	165	23	are	be	VBP
cord-018265-twp33bb6	165	24	proposed	propose	VBN
cord-018265-twp33bb6	165	25	both	both	CC
cord-018265-twp33bb6	165	26	as	as	IN
cord-018265-twp33bb6	165	27	vaccine	vaccine	NN
cord-018265-twp33bb6	165	28	vectors	vector	NNS
cord-018265-twp33bb6	165	29	and	and	CC
cord-018265-twp33bb6	165	30	as	as	IN
cord-018265-twp33bb6	165	31	tools	tool	NNS
cord-018265-twp33bb6	165	32	for	for	IN
cord-018265-twp33bb6	165	33	the	the	DT
cord-018265-twp33bb6	165	34	transfer	transfer	NN
cord-018265-twp33bb6	165	35	of	of	IN
cord-018265-twp33bb6	165	36	foreign	foreign	JJ
cord-018265-twp33bb6	165	37	genes	gene	NNS
cord-018265-twp33bb6	165	38	in	in	IN
cord-018265-twp33bb6	165	39	gene	gene	NN
cord-018265-twp33bb6	165	40	therapy	therapy	NN
cord-018265-twp33bb6	165	41	protocols	protocol	NNS
cord-018265-twp33bb6	165	42	.	.	.
cord-018265-twp33bb6	166	1	Polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	166	2	-	-	HYPH
cord-018265-twp33bb6	166	3	based	base	VBN
cord-018265-twp33bb6	166	4	vaccines	vaccine	NNS
cord-018265-twp33bb6	166	5	against	against	IN
cord-018265-twp33bb6	166	6	S.	S.	NNP
cord-018265-twp33bb6	166	7	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	166	8	In	in	IN
cord-018265-twp33bb6	166	9	1945	1945	CD
cord-018265-twp33bb6	166	10	,	,	,
cord-018265-twp33bb6	166	11	MacLeod	MacLeod	NNP
cord-018265-twp33bb6	166	12	et	et	NNP
cord-018265-twp33bb6	166	13	al	al	NNP
cord-018265-twp33bb6	166	14	.	.	.
cord-018265-twp33bb6	167	1	[	[	-LRB-
cord-018265-twp33bb6	167	2	53	53	CD
cord-018265-twp33bb6	167	3	]	]	-RRB-
cord-018265-twp33bb6	167	4	reported	report	VBD
cord-018265-twp33bb6	167	5	the	the	DT
cord-018265-twp33bb6	167	6	protective	protective	JJ
cord-018265-twp33bb6	167	7	efficacy	efficacy	NN
cord-018265-twp33bb6	167	8	of	of	IN
cord-018265-twp33bb6	167	9	a	a	DT
cord-018265-twp33bb6	167	10	capsular	capsular	JJ
cord-018265-twp33bb6	167	11	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	167	12	(	(	-LRB-
cord-018265-twp33bb6	167	13	PS	PS	NNP
cord-018265-twp33bb6	167	14	)	)	-RRB-
cord-018265-twp33bb6	167	15	vaccine	vaccine	NN
cord-018265-twp33bb6	167	16	in	in	IN
cord-018265-twp33bb6	167	17	military	military	JJ
cord-018265-twp33bb6	167	18	personnel	personnel	NNS
cord-018265-twp33bb6	167	19	during	during	IN
cord-018265-twp33bb6	167	20	an	an	DT
cord-018265-twp33bb6	167	21	outbreak	outbreak	NN
cord-018265-twp33bb6	167	22	of	of	IN
cord-018265-twp33bb6	167	23	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	167	24	pneumonia	pneumonia	NN
cord-018265-twp33bb6	167	25	.	.	.
cord-018265-twp33bb6	168	1	The	the	DT
cord-018265-twp33bb6	168	2	immunization	immunization	NN
cord-018265-twp33bb6	168	3	with	with	IN
cord-018265-twp33bb6	168	4	purified	purify	VBN
cord-018265-twp33bb6	168	5	PS	PS	NNP
cord-018265-twp33bb6	168	6	showed	show	VBD
cord-018265-twp33bb6	168	7	a	a	DT
cord-018265-twp33bb6	168	8	drastically	drastically	RB
cord-018265-twp33bb6	168	9	reduced	reduce	VBN
cord-018265-twp33bb6	168	10	reactogenicity	reactogenicity	NN
cord-018265-twp33bb6	168	11	,	,	,
cord-018265-twp33bb6	168	12	in	in	IN
cord-018265-twp33bb6	168	13	comparison	comparison	NN
cord-018265-twp33bb6	168	14	with	with	IN
cord-018265-twp33bb6	168	15	the	the	DT
cord-018265-twp33bb6	168	16	previously	previously	RB
cord-018265-twp33bb6	168	17	used	use	VBN
cord-018265-twp33bb6	168	18	inactivated	inactivate	VBN
cord-018265-twp33bb6	168	19	whole	whole	JJ
cord-018265-twp33bb6	168	20	cell	cell	NN
cord-018265-twp33bb6	168	21	vaccines	vaccine	NNS
cord-018265-twp33bb6	168	22	.	.	.
cord-018265-twp33bb6	169	1	This	this	DT
cord-018265-twp33bb6	169	2	was	be	VBD
cord-018265-twp33bb6	169	3	a	a	DT
cord-018265-twp33bb6	169	4	major	major	JJ
cord-018265-twp33bb6	169	5	breakthrough	breakthrough	NN
cord-018265-twp33bb6	169	6	,	,	,
cord-018265-twp33bb6	169	7	not	not	RB
cord-018265-twp33bb6	169	8	only	only	RB
cord-018265-twp33bb6	169	9	in	in	IN
cord-018265-twp33bb6	169	10	terms	term	NNS
cord-018265-twp33bb6	169	11	of	of	IN
cord-018265-twp33bb6	169	12	safety	safety	NN
cord-018265-twp33bb6	169	13	,	,	,
cord-018265-twp33bb6	169	14	but	but	CC
cord-018265-twp33bb6	169	15	also	also	RB
cord-018265-twp33bb6	169	16	because	because	IN
cord-018265-twp33bb6	169	17	it	-PRON-	PRP
cord-018265-twp33bb6	169	18	demonstrated	demonstrate	VBD
cord-018265-twp33bb6	169	19	that	that	IN
cord-018265-twp33bb6	169	20	a	a	DT
cord-018265-twp33bb6	169	21	specific	specific	JJ
cord-018265-twp33bb6	169	22	virulence	virulence	NN
cord-018265-twp33bb6	169	23	factor	factor	NN
cord-018265-twp33bb6	169	24	can	can	MD
cord-018265-twp33bb6	169	25	be	be	VB
cord-018265-twp33bb6	169	26	purified	purify	VBN
cord-018265-twp33bb6	169	27	and	and	CC
cord-018265-twp33bb6	169	28	effectively	effectively	RB
cord-018265-twp33bb6	169	29	implemented	implement	VBN
cord-018265-twp33bb6	169	30	for	for	IN
cord-018265-twp33bb6	169	31	the	the	DT
cord-018265-twp33bb6	169	32	prevention	prevention	NN
cord-018265-twp33bb6	169	33	of	of	IN
cord-018265-twp33bb6	169	34	an	an	DT
cord-018265-twp33bb6	169	35	infectious	infectious	JJ
cord-018265-twp33bb6	169	36	disease	disease	NN
cord-018265-twp33bb6	169	37	,	,	,
cord-018265-twp33bb6	169	38	thereby	thereby	RB
cord-018265-twp33bb6	169	39	paving	pave	VBG
cord-018265-twp33bb6	169	40	the	the	DT
cord-018265-twp33bb6	169	41	road	road	NN
cord-018265-twp33bb6	169	42	for	for	IN
cord-018265-twp33bb6	169	43	modern	modern	JJ
cord-018265-twp33bb6	169	44	non	non	JJ
cord-018265-twp33bb6	169	45	toxoid	toxoid	NN
cord-018265-twp33bb6	169	46	-	-	HYPH
cord-018265-twp33bb6	169	47	based	base	VBN
cord-018265-twp33bb6	169	48	subunit	subunit	NN
cord-018265-twp33bb6	169	49	vaccines	vaccine	NNS
cord-018265-twp33bb6	169	50	.	.	.
cord-018265-twp33bb6	170	1	Although	although	IN
cord-018265-twp33bb6	170	2	the	the	DT
cord-018265-twp33bb6	170	3	serological	serological	JJ
cord-018265-twp33bb6	170	4	correlates	correlate	NNS
cord-018265-twp33bb6	170	5	of	of	IN
cord-018265-twp33bb6	170	6	immunity	immunity	NN
cord-018265-twp33bb6	170	7	are	be	VBP
cord-018265-twp33bb6	170	8	poorly	poorly	RB
cord-018265-twp33bb6	170	9	defined	define	VBN
cord-018265-twp33bb6	170	10	,	,	,
cord-018265-twp33bb6	170	11	type	type	NN
cord-018265-twp33bb6	170	12	-	-	HYPH
cord-018265-twp33bb6	170	13	specific	specific	JJ
cord-018265-twp33bb6	170	14	anti	anti	JJ
cord-018265-twp33bb6	170	15	-	-	JJ
cord-018265-twp33bb6	170	16	capsular	capsular	JJ
cord-018265-twp33bb6	170	17	antibodies	antibody	NNS
cord-018265-twp33bb6	170	18	are	be	VBP
cord-018265-twp33bb6	170	19	responsible	responsible	JJ
cord-018265-twp33bb6	170	20	for	for	IN
cord-018265-twp33bb6	170	21	protective	protective	JJ
cord-018265-twp33bb6	170	22	immu	immu	NN
cord-018265-twp33bb6	170	23	-	-	HYPH
cord-018265-twp33bb6	170	24	nity	nity	NN
cord-018265-twp33bb6	170	25	.	.	.
cord-018265-twp33bb6	171	1	However	however	RB
cord-018265-twp33bb6	171	2	,	,	,
cord-018265-twp33bb6	171	3	immunity	immunity	NN
cord-018265-twp33bb6	171	4	is	be	VBZ
cord-018265-twp33bb6	171	5	serotype	serotype	NN
cord-018265-twp33bb6	171	6	specific	specific	JJ
cord-018265-twp33bb6	171	7	,	,	,
cord-018265-twp33bb6	171	8	rendering	render	VBG
cord-018265-twp33bb6	171	9	extremely	extremely	RB
cord-018265-twp33bb6	171	10	difficult	difficult	JJ
cord-018265-twp33bb6	171	11	the	the	DT
cord-018265-twp33bb6	171	12	development	development	NN
cord-018265-twp33bb6	171	13	of	of	IN
cord-018265-twp33bb6	171	14	a	a	DT
cord-018265-twp33bb6	171	15	universal	universal	JJ
cord-018265-twp33bb6	171	16	vaccine	vaccine	NN
cord-018265-twp33bb6	171	17	.	.	.
cord-018265-twp33bb6	172	1	This	this	DT
cord-018265-twp33bb6	172	2	is	be	VBZ
cord-018265-twp33bb6	172	3	in	in	IN
cord-018265-twp33bb6	172	4	part	part	NN
cord-018265-twp33bb6	172	5	due	due	IN
cord-018265-twp33bb6	172	6	to	to	IN
cord-018265-twp33bb6	172	7	the	the	DT
cord-018265-twp33bb6	172	8	elevate	elevate	JJ
cord-018265-twp33bb6	172	9	number	number	NN
cord-018265-twp33bb6	172	10	of	of	IN
cord-018265-twp33bb6	172	11	serotypes	serotype	NNS
cord-018265-twp33bb6	172	12	,	,	,
cord-018265-twp33bb6	172	13	the	the	DT
cord-018265-twp33bb6	172	14	regional	regional	JJ
cord-018265-twp33bb6	172	15	variations	variation	NNS
cord-018265-twp33bb6	172	16	in	in	IN
cord-018265-twp33bb6	172	17	dominant	dominant	JJ
cord-018265-twp33bb6	172	18	serotypes	serotype	NNS
cord-018265-twp33bb6	172	19	and	and	CC
cord-018265-twp33bb6	172	20	the	the	DT
cord-018265-twp33bb6	172	21	lack	lack	NN
cord-018265-twp33bb6	172	22	of	of	IN
cord-018265-twp33bb6	172	23	updated	update	VBN
cord-018265-twp33bb6	172	24	sero	sero	NN
cord-018265-twp33bb6	172	25	-	-	HYPH
cord-018265-twp33bb6	172	26	prevalence	prevalence	NN
cord-018265-twp33bb6	172	27	data	datum	NNS
cord-018265-twp33bb6	172	28	for	for	IN
cord-018265-twp33bb6	172	29	certain	certain	JJ
cord-018265-twp33bb6	172	30	regions	region	NNS
cord-018265-twp33bb6	172	31	.	.	.
cord-018265-twp33bb6	173	1	These	these	DT
cord-018265-twp33bb6	173	2	problems	problem	NNS
cord-018265-twp33bb6	173	3	have	have	VBP
cord-018265-twp33bb6	173	4	been	be	VBN
cord-018265-twp33bb6	173	5	partially	partially	RB
cord-018265-twp33bb6	173	6	solved	solve	VBN
cord-018265-twp33bb6	173	7	by	by	IN
cord-018265-twp33bb6	173	8	the	the	DT
cord-018265-twp33bb6	173	9	use	use	NN
cord-018265-twp33bb6	173	10	of	of	IN
cord-018265-twp33bb6	173	11	PS	PS	NNP
cord-018265-twp33bb6	173	12	-	-	HYPH
cord-018265-twp33bb6	173	13	based	base	VBN
cord-018265-twp33bb6	173	14	polyvalent	polyvalent	JJ
cord-018265-twp33bb6	173	15	vaccines	vaccine	NNS
cord-018265-twp33bb6	173	16	.	.	.
cord-018265-twp33bb6	174	1	The	the	DT
cord-018265-twp33bb6	174	2	currently	currently	RB
cord-018265-twp33bb6	174	3	licensed	license	VBN
cord-018265-twp33bb6	174	4	formulations	formulation	NNS
cord-018265-twp33bb6	174	5	contain	contain	VBP
cord-018265-twp33bb6	174	6	23	23	CD
cord-018265-twp33bb6	174	7	serotypes	serotype	NNS
cord-018265-twp33bb6	174	8	of	of	IN
cord-018265-twp33bb6	174	9	S.	S.	NNP
cord-018265-twp33bb6	174	10	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	174	11	,	,	,
cord-018265-twp33bb6	174	12	which	which	WDT
cord-018265-twp33bb6	174	13	cover	cover	VBP
cord-018265-twp33bb6	174	14	approximately	approximately	RB
cord-018265-twp33bb6	174	15	90	90	CD
cord-018265-twp33bb6	174	16	%	%	NN
cord-018265-twp33bb6	174	17	of	of	IN
cord-018265-twp33bb6	174	18	serious	serious	JJ
cord-018265-twp33bb6	174	19	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	174	20	disease	disease	NN
cord-018265-twp33bb6	174	21	,	,	,
cord-018265-twp33bb6	174	22	but	but	CC
cord-018265-twp33bb6	174	23	only	only	RB
cord-018265-twp33bb6	174	24	in	in	IN
cord-018265-twp33bb6	174	25	Western	western	JJ
cord-018265-twp33bb6	174	26	industrialized	industrialize	VBN
cord-018265-twp33bb6	174	27	countries	country	NNS
cord-018265-twp33bb6	174	28	.	.	.
cord-018265-twp33bb6	175	1	Relatively	relatively	RB
cord-018265-twp33bb6	175	2	good	good	JJ
cord-018265-twp33bb6	175	3	antibody	antibody	NN
cord-018265-twp33bb6	175	4	responses	response	NNS
cord-018265-twp33bb6	175	5	(	(	-LRB-
cord-018265-twp33bb6	175	6	60	60	CD
cord-018265-twp33bb6	175	7	-	-	SYM
cord-018265-twp33bb6	175	8	70	70	CD
cord-018265-twp33bb6	175	9	%	%	NN
cord-018265-twp33bb6	175	10	)	)	-RRB-
cord-018265-twp33bb6	175	11	are	be	VBP
cord-018265-twp33bb6	175	12	elicited	elicit	VBN
cord-018265-twp33bb6	175	13	in	in	IN
cord-018265-twp33bb6	175	14	healthy	healthy	JJ
cord-018265-twp33bb6	175	15	adults	adult	NNS
cord-018265-twp33bb6	175	16	2	2	CD
cord-018265-twp33bb6	175	17	-	-	SYM
cord-018265-twp33bb6	175	18	3	3	CD
cord-018265-twp33bb6	175	19	weeks	week	NNS
cord-018265-twp33bb6	175	20	after	after	IN
cord-018265-twp33bb6	175	21	a	a	DT
cord-018265-twp33bb6	175	22	single	single	JJ
cord-018265-twp33bb6	175	23	intramuscular	intramuscular	JJ
cord-018265-twp33bb6	175	24	or	or	CC
cord-018265-twp33bb6	175	25	subcutaneous	subcutaneous	JJ
cord-018265-twp33bb6	175	26	immunization	immunization	NN
cord-018265-twp33bb6	175	27	[	[	-LRB-
cord-018265-twp33bb6	175	28	54	54	CD
cord-018265-twp33bb6	175	29	]	]	-RRB-
cord-018265-twp33bb6	175	30	.	.	.
cord-018265-twp33bb6	176	1	Unfortunately	unfortunately	RB
cord-018265-twp33bb6	176	2	,	,	,
cord-018265-twp33bb6	176	3	they	-PRON-	PRP
cord-018265-twp33bb6	176	4	are	be	VBP
cord-018265-twp33bb6	176	5	poorly	poorly	RB
cord-018265-twp33bb6	176	6	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	176	7	in	in	IN
cord-018265-twp33bb6	176	8	children	child	NNS
cord-018265-twp33bb6	176	9	aged	age	VBN
cord-018265-twp33bb6	176	10	less	less	JJR
cord-018265-twp33bb6	176	11	than	than	IN
cord-018265-twp33bb6	176	12	2	2	CD
cord-018265-twp33bb6	176	13	years	year	NNS
cord-018265-twp33bb6	176	14	,	,	,
cord-018265-twp33bb6	176	15	in	in	IN
cord-018265-twp33bb6	176	16	immune	immune	JJ
cord-018265-twp33bb6	176	17	compromised	compromise	VBN
cord-018265-twp33bb6	176	18	individuals	individual	NNS
cord-018265-twp33bb6	176	19	(	(	-LRB-
cord-018265-twp33bb6	176	20	e.g.	e.g.	RB
cord-018265-twp33bb6	176	21	,	,	,
cord-018265-twp33bb6	176	22	AIDS	AIDS	NNP
cord-018265-twp33bb6	176	23	patients	patient	NNS
cord-018265-twp33bb6	176	24	)	)	-RRB-
cord-018265-twp33bb6	176	25	and	and	CC
cord-018265-twp33bb6	176	26	in	in	IN
cord-018265-twp33bb6	176	27	elderly	elderly	JJ
cord-018265-twp33bb6	176	28	people	people	NNS
cord-018265-twp33bb6	176	29	with	with	IN
cord-018265-twp33bb6	176	30	concomitant	concomitant	JJ
cord-018265-twp33bb6	176	31	disease	disease	NN
cord-018265-twp33bb6	176	32	,	,	,
cord-018265-twp33bb6	176	33	and	and	CC
cord-018265-twp33bb6	176	34	they	-PRON-	PRP
cord-018265-twp33bb6	176	35	do	do	VBP
cord-018265-twp33bb6	176	36	not	not	RB
cord-018265-twp33bb6	176	37	induce	induce	VB
cord-018265-twp33bb6	176	38	good	good	JJ
cord-018265-twp33bb6	176	39	immunological	immunological	JJ
cord-018265-twp33bb6	176	40	memory	memory	NN
cord-018265-twp33bb6	176	41	.	.	.
cord-018265-twp33bb6	177	1	Randomized	randomized	JJ
cord-018265-twp33bb6	177	2	controlled	control	VBN
cord-018265-twp33bb6	177	3	trials	trial	NNS
cord-018265-twp33bb6	177	4	in	in	IN
cord-018265-twp33bb6	177	5	healthy	healthy	JJ
cord-018265-twp33bb6	177	6	elderly	elderly	JJ
cord-018265-twp33bb6	177	7	and	and	CC
cord-018265-twp33bb6	177	8	young	young	JJ
cord-018265-twp33bb6	177	9	men	man	NNS
cord-018265-twp33bb6	177	10	also	also	RB
cord-018265-twp33bb6	177	11	failed	fail	VBD
cord-018265-twp33bb6	177	12	to	to	TO
cord-018265-twp33bb6	177	13	show	show	VB
cord-018265-twp33bb6	177	14	a	a	DT
cord-018265-twp33bb6	177	15	beneficial	beneficial	JJ
cord-018265-twp33bb6	177	16	effect	effect	NN
cord-018265-twp33bb6	177	17	against	against	IN
cord-018265-twp33bb6	177	18	pneumonia	pneumonia	NN
cord-018265-twp33bb6	177	19	[	[	-LRB-
cord-018265-twp33bb6	177	20	55	55	CD
cord-018265-twp33bb6	177	21	]	]	-RRB-
cord-018265-twp33bb6	177	22	.	.	.
cord-018265-twp33bb6	178	1	However	however	RB
cord-018265-twp33bb6	178	2	,	,	,
cord-018265-twp33bb6	178	3	vaccination	vaccination	NN
cord-018265-twp33bb6	178	4	is	be	VBZ
cord-018265-twp33bb6	178	5	recommended	recommend	VBN
cord-018265-twp33bb6	178	6	for	for	IN
cord-018265-twp33bb6	178	7	healthy	healthy	JJ
cord-018265-twp33bb6	178	8	people	people	NNS
cord-018265-twp33bb6	178	9	over	over	IN
cord-018265-twp33bb6	178	10	65	65	CD
cord-018265-twp33bb6	178	11	years	year	NNS
cord-018265-twp33bb6	178	12	of	of	IN
cord-018265-twp33bb6	178	13	age	age	NN
cord-018265-twp33bb6	178	14	to	to	TO
cord-018265-twp33bb6	178	15	confer	confer	VB
cord-018265-twp33bb6	178	16	protection	protection	NN
cord-018265-twp33bb6	178	17	against	against	IN
cord-018265-twp33bb6	178	18	invasive	invasive	JJ
cord-018265-twp33bb6	178	19	disease	disease	NN
cord-018265-twp33bb6	178	20	[	[	-LRB-
cord-018265-twp33bb6	178	21	54	54	CD
cord-018265-twp33bb6	178	22	]	]	-RRB-
cord-018265-twp33bb6	178	23	.	.	.
cord-018265-twp33bb6	179	1	PS	PS	NNP
cord-018265-twp33bb6	179	2	-	-	HYPH
cord-018265-twp33bb6	179	3	based	base	VBN
cord-018265-twp33bb6	179	4	vaccines	vaccine	NNS
cord-018265-twp33bb6	179	5	can	can	MD
cord-018265-twp33bb6	179	6	be	be	VB
cord-018265-twp33bb6	179	7	also	also	RB
cord-018265-twp33bb6	179	8	used	use	VBN
cord-018265-twp33bb6	179	9	in	in	IN
cord-018265-twp33bb6	179	10	pregnant	pregnant	JJ
cord-018265-twp33bb6	179	11	women	woman	NNS
cord-018265-twp33bb6	179	12	to	to	TO
cord-018265-twp33bb6	179	13	stimulate	stimulate	VB
cord-018265-twp33bb6	179	14	the	the	DT
cord-018265-twp33bb6	179	15	production	production	NN
cord-018265-twp33bb6	179	16	of	of	IN
cord-018265-twp33bb6	179	17	antibodies	antibody	NNS
cord-018265-twp33bb6	179	18	,	,	,
cord-018265-twp33bb6	179	19	which	which	WDT
cord-018265-twp33bb6	179	20	are	be	VBP
cord-018265-twp33bb6	179	21	transferred	transfer	VBN
cord-018265-twp33bb6	179	22	to	to	IN
cord-018265-twp33bb6	179	23	the	the	DT
cord-018265-twp33bb6	179	24	foetus	foetus	NN
cord-018265-twp33bb6	179	25	via	via	IN
cord-018265-twp33bb6	179	26	the	the	DT
cord-018265-twp33bb6	179	27	placenta	placenta	NN
cord-018265-twp33bb6	179	28	or	or	CC
cord-018265-twp33bb6	179	29	to	to	IN
cord-018265-twp33bb6	179	30	the	the	DT
cord-018265-twp33bb6	179	31	newborns	newborn	NNS
cord-018265-twp33bb6	179	32	by	by	IN
cord-018265-twp33bb6	179	33	breast	breast	NN
cord-018265-twp33bb6	179	34	-	-	HYPH
cord-018265-twp33bb6	179	35	feeding	feeding	NN
cord-018265-twp33bb6	179	36	.	.	.
cord-018265-twp33bb6	180	1	However	however	RB
cord-018265-twp33bb6	180	2	,	,	,
cord-018265-twp33bb6	180	3	it	-PRON-	PRP
cord-018265-twp33bb6	180	4	is	be	VBZ
cord-018265-twp33bb6	180	5	still	still	RB
cord-018265-twp33bb6	180	6	a	a	DT
cord-018265-twp33bb6	180	7	matter	matter	NN
cord-018265-twp33bb6	180	8	of	of	IN
cord-018265-twp33bb6	180	9	controversy	controversy	NN
cord-018265-twp33bb6	180	10	whether	whether	IN
cord-018265-twp33bb6	180	11	maternal	maternal	JJ
cord-018265-twp33bb6	180	12	vaccination	vaccination	NN
cord-018265-twp33bb6	180	13	can	can	MD
cord-018265-twp33bb6	180	14	indeed	indeed	RB
cord-018265-twp33bb6	180	15	protect	protect	VB
cord-018265-twp33bb6	180	16	newborns	newborn	NNS
cord-018265-twp33bb6	180	17	against	against	IN
cord-018265-twp33bb6	180	18	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	180	19	infections	infection	NNS
cord-018265-twp33bb6	180	20	[	[	-LRB-
cord-018265-twp33bb6	180	21	56	56	CD
cord-018265-twp33bb6	180	22	]	]	-RRB-
cord-018265-twp33bb6	180	23	.	.	.
cord-018265-twp33bb6	181	1	The	the	DT
cord-018265-twp33bb6	181	2	second	second	JJ
cord-018265-twp33bb6	181	3	generation	generation	NN
cord-018265-twp33bb6	181	4	of	of	IN
cord-018265-twp33bb6	181	5	PS	PS	NNP
cord-018265-twp33bb6	181	6	-	-	HYPH
cord-018265-twp33bb6	181	7	based	base	VBN
cord-018265-twp33bb6	181	8	conjugate	conjugate	NN
cord-018265-twp33bb6	181	9	vaccines	vaccine	NNS
cord-018265-twp33bb6	181	10	stimulates	stimulate	VBZ
cord-018265-twp33bb6	181	11	stronger	strong	JJR
cord-018265-twp33bb6	181	12	antibody	antibody	NN
cord-018265-twp33bb6	181	13	responses	response	NNS
cord-018265-twp33bb6	181	14	,	,	,
cord-018265-twp33bb6	181	15	even	even	RB
cord-018265-twp33bb6	181	16	in	in	IN
cord-018265-twp33bb6	181	17	infants	infant	NNS
cord-018265-twp33bb6	181	18	,	,	,
cord-018265-twp33bb6	181	19	young	young	JJ
cord-018265-twp33bb6	181	20	children	child	NNS
cord-018265-twp33bb6	181	21	and	and	CC
cord-018265-twp33bb6	181	22	immune	immune	JJ
cord-018265-twp33bb6	181	23	deficient	deficient	JJ
cord-018265-twp33bb6	181	24	individuals	individual	NNS
cord-018265-twp33bb6	181	25	,	,	,
cord-018265-twp33bb6	181	26	as	as	RB
cord-018265-twp33bb6	181	27	well	well	RB
cord-018265-twp33bb6	181	28	as	as	IN
cord-018265-twp33bb6	181	29	immunological	immunological	JJ
cord-018265-twp33bb6	181	30	memory	memory	NN
cord-018265-twp33bb6	181	31	.	.	.
cord-018265-twp33bb6	182	1	These	these	DT
cord-018265-twp33bb6	182	2	vaccines	vaccine	NNS
cord-018265-twp33bb6	182	3	also	also	RB
cord-018265-twp33bb6	182	4	suppress	suppress	VBP
cord-018265-twp33bb6	182	5	nasopharyngeal	nasopharyngeal	JJ
cord-018265-twp33bb6	182	6	carriage	carriage	NN
cord-018265-twp33bb6	182	7	of	of	IN
cord-018265-twp33bb6	182	8	the	the	DT
cord-018265-twp33bb6	182	9	pathogen	pathogen	NN
cord-018265-twp33bb6	182	10	and	and	CC
cord-018265-twp33bb6	182	11	reduce	reduce	VB
cord-018265-twp33bb6	182	12	bacterial	bacterial	JJ
cord-018265-twp33bb6	182	13	transmission	transmission	NN
cord-018265-twp33bb6	182	14	in	in	IN
cord-018265-twp33bb6	182	15	the	the	DT
cord-018265-twp33bb6	182	16	community	community	NN
cord-018265-twp33bb6	182	17	leading	lead	VBG
cord-018265-twp33bb6	182	18	to	to	TO
cord-018265-twp33bb6	182	19	herd	herd	VB
cord-018265-twp33bb6	182	20	immunity	immunity	NN
cord-018265-twp33bb6	182	21	,	,	,
cord-018265-twp33bb6	182	22	which	which	WDT
cord-018265-twp33bb6	182	23	adds	add	VBZ
cord-018265-twp33bb6	182	24	considerable	considerable	JJ
cord-018265-twp33bb6	182	25	value	value	NN
cord-018265-twp33bb6	182	26	to	to	IN
cord-018265-twp33bb6	182	27	their	-PRON-	PRP$
cord-018265-twp33bb6	182	28	implementation	implementation	NN
cord-018265-twp33bb6	182	29	.	.	.
cord-018265-twp33bb6	183	1	The	the	DT
cord-018265-twp33bb6	183	2	introduction	introduction	NN
cord-018265-twp33bb6	183	3	of	of	IN
cord-018265-twp33bb6	183	4	these	these	DT
cord-018265-twp33bb6	183	5	vaccines	vaccine	NNS
cord-018265-twp33bb6	183	6	in	in	IN
cord-018265-twp33bb6	183	7	USA	USA	NNP
cord-018265-twp33bb6	183	8	in	in	IN
cord-018265-twp33bb6	183	9	2000	2000	CD
cord-018265-twp33bb6	183	10	resulted	result	VBD
cord-018265-twp33bb6	183	11	in	in	IN
cord-018265-twp33bb6	183	12	a	a	DT
cord-018265-twp33bb6	183	13	dramatic	dramatic	JJ
cord-018265-twp33bb6	183	14	decline	decline	NN
cord-018265-twp33bb6	183	15	in	in	IN
cord-018265-twp33bb6	183	16	the	the	DT
cord-018265-twp33bb6	183	17	rates	rate	NNS
cord-018265-twp33bb6	183	18	of	of	IN
cord-018265-twp33bb6	183	19	invasive	invasive	JJ
cord-018265-twp33bb6	183	20	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	183	21	disease	disease	NN
cord-018265-twp33bb6	183	22	[	[	-LRB-
cord-018265-twp33bb6	183	23	1	1	CD
cord-018265-twp33bb6	183	24	,	,	,
cord-018265-twp33bb6	183	25	57	57	CD
cord-018265-twp33bb6	183	26	,	,	,
cord-018265-twp33bb6	183	27	58	58	CD
cord-018265-twp33bb6	183	28	]	]	-RRB-
cord-018265-twp33bb6	183	29	.	.	.
cord-018265-twp33bb6	184	1	A	a	DT
cord-018265-twp33bb6	184	2	significant	significant	JJ
cord-018265-twp33bb6	184	3	reduction	reduction	NN
cord-018265-twp33bb6	184	4	in	in	IN
cord-018265-twp33bb6	184	5	the	the	DT
cord-018265-twp33bb6	184	6	incidence	incidence	NN
cord-018265-twp33bb6	184	7	rates	rate	NNS
cord-018265-twp33bb6	184	8	among	among	IN
cord-018265-twp33bb6	184	9	non	non	JJ
cord-018265-twp33bb6	184	10	vaccinated	vaccinated	JJ
cord-018265-twp33bb6	184	11	individuals	individual	NNS
cord-018265-twp33bb6	184	12	was	be	VBD
cord-018265-twp33bb6	184	13	also	also	RB
cord-018265-twp33bb6	184	14	observed	observe	VBN
cord-018265-twp33bb6	184	15	as	as	IN
cord-018265-twp33bb6	184	16	a	a	DT
cord-018265-twp33bb6	184	17	result	result	NN
cord-018265-twp33bb6	184	18	of	of	IN
cord-018265-twp33bb6	184	19	herd	herd	NN
cord-018265-twp33bb6	184	20	immunity	immunity	NN
cord-018265-twp33bb6	184	21	[	[	-LRB-
cord-018265-twp33bb6	184	22	59	59	CD
cord-018265-twp33bb6	184	23	,	,	,
cord-018265-twp33bb6	184	24	60	60	CD
cord-018265-twp33bb6	184	25	]	]	-RRB-
cord-018265-twp33bb6	184	26	.	.	.
cord-018265-twp33bb6	185	1	However	however	RB
cord-018265-twp33bb6	185	2	,	,	,
cord-018265-twp33bb6	185	3	the	the	DT
cord-018265-twp33bb6	185	4	licensed	licensed	JJ
cord-018265-twp33bb6	185	5	seven	seven	CD
cord-018265-twp33bb6	185	6	-	-	HYPH
cord-018265-twp33bb6	185	7	valent	valent	NN
cord-018265-twp33bb6	185	8	vaccine	vaccine	NN
cord-018265-twp33bb6	185	9	does	do	VBZ
cord-018265-twp33bb6	185	10	not	not	RB
cord-018265-twp33bb6	185	11	contain	contain	VB
cord-018265-twp33bb6	185	12	some	some	DT
cord-018265-twp33bb6	185	13	of	of	IN
cord-018265-twp33bb6	185	14	serotypes	serotype	NNS
cord-018265-twp33bb6	185	15	that	that	WDT
cord-018265-twp33bb6	185	16	cause	cause	VBP
cord-018265-twp33bb6	185	17	severe	severe	JJ
cord-018265-twp33bb6	185	18	disease	disease	NN
cord-018265-twp33bb6	185	19	in	in	IN
cord-018265-twp33bb6	185	20	developing	develop	VBG
cord-018265-twp33bb6	185	21	countries	country	NNS
cord-018265-twp33bb6	185	22	(	(	-LRB-
cord-018265-twp33bb6	185	23	i.e.	i.e.	FW
cord-018265-twp33bb6	185	24	,	,	,
cord-018265-twp33bb6	185	25	serotypes	serotypes	NN
cord-018265-twp33bb6	185	26	1	1	CD
cord-018265-twp33bb6	185	27	and	and	CC
cord-018265-twp33bb6	185	28	5	5	CD
cord-018265-twp33bb6	185	29	)	)	-RRB-
cord-018265-twp33bb6	185	30	.	.	.
cord-018265-twp33bb6	186	1	New	new	JJ
cord-018265-twp33bb6	186	2	conjugate	conjugate	NN
cord-018265-twp33bb6	186	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	186	4	including	include	VBG
cord-018265-twp33bb6	186	5	more	more	JJR
cord-018265-twp33bb6	186	6	serotypes	serotype	NNS
cord-018265-twp33bb6	186	7	,	,	,
cord-018265-twp33bb6	186	8	such	such	JJ
cord-018265-twp33bb6	186	9	as	as	IN
cord-018265-twp33bb6	186	10	the	the	DT
cord-018265-twp33bb6	186	11	ninevalent	ninevalent	NNP
cord-018265-twp33bb6	186	12	vaccine	vaccine	NN
cord-018265-twp33bb6	186	13	(	(	-LRB-
cord-018265-twp33bb6	186	14	Wyeth	Wyeth	NNP
cord-018265-twp33bb6	186	15	)	)	-RRB-
cord-018265-twp33bb6	186	16	and	and	CC
cord-018265-twp33bb6	186	17	two	two	CD
cord-018265-twp33bb6	186	18	11-valent	11-valent	CD
cord-018265-twp33bb6	186	19	vaccines	vaccine	NNS
cord-018265-twp33bb6	186	20	(	(	-LRB-
cord-018265-twp33bb6	186	21	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-018265-twp33bb6	186	22	and	and	CC
cord-018265-twp33bb6	186	23	Sanofi	Sanofi	NNP
cord-018265-twp33bb6	186	24	-	-	HYPH
cord-018265-twp33bb6	186	25	Pasteur	Pasteur	NNP
cord-018265-twp33bb6	186	26	)	)	-RRB-
cord-018265-twp33bb6	186	27	,	,	,
cord-018265-twp33bb6	186	28	should	should	MD
cord-018265-twp33bb6	186	29	provide	provide	VB
cord-018265-twp33bb6	186	30	better	well	JJR
cord-018265-twp33bb6	186	31	serotype	serotype	NN
cord-018265-twp33bb6	186	32	coverage	coverage	NN
cord-018265-twp33bb6	186	33	.	.	.
cord-018265-twp33bb6	187	1	New	new	JJ
cord-018265-twp33bb6	187	2	approaches	approach	NNS
cord-018265-twp33bb6	187	3	to	to	TO
cord-018265-twp33bb6	187	4	develop	develop	VB
cord-018265-twp33bb6	187	5	protein	protein	NN
cord-018265-twp33bb6	187	6	-	-	HYPH
cord-018265-twp33bb6	187	7	based	base	VBN
cord-018265-twp33bb6	187	8	subunit	subunit	NN
cord-018265-twp33bb6	187	9	vaccines	vaccine	NNS
cord-018265-twp33bb6	187	10	against	against	IN
cord-018265-twp33bb6	187	11	S.	S.	NNP
cord-018265-twp33bb6	187	12	pneumoniae	pneumoniae	NNS
cord-018265-twp33bb6	187	13	are	be	VBP
cord-018265-twp33bb6	187	14	currently	currently	RB
cord-018265-twp33bb6	187	15	being	be	VBG
cord-018265-twp33bb6	187	16	pursued	pursue	VBN
cord-018265-twp33bb6	187	17	by	by	IN
cord-018265-twp33bb6	187	18	different	different	JJ
cord-018265-twp33bb6	187	19	research	research	NN
cord-018265-twp33bb6	187	20	groups	group	NNS
cord-018265-twp33bb6	187	21	.	.	.
cord-018265-twp33bb6	188	1	This	this	DT
cord-018265-twp33bb6	188	2	is	be	VBZ
cord-018265-twp33bb6	188	3	expected	expect	VBN
cord-018265-twp33bb6	188	4	to	to	TO
cord-018265-twp33bb6	188	5	enable	enable	VB
cord-018265-twp33bb6	188	6	the	the	DT
cord-018265-twp33bb6	188	7	generation	generation	NN
cord-018265-twp33bb6	188	8	of	of	IN
cord-018265-twp33bb6	188	9	a	a	DT
cord-018265-twp33bb6	188	10	universal	universal	JJ
cord-018265-twp33bb6	188	11	vaccine	vaccine	NN
cord-018265-twp33bb6	188	12	conferring	confer	VBG
cord-018265-twp33bb6	188	13	protective	protective	JJ
cord-018265-twp33bb6	188	14	immunity	immunity	NN
cord-018265-twp33bb6	188	15	against	against	IN
cord-018265-twp33bb6	188	16	a	a	DT
cord-018265-twp33bb6	188	17	large	large	JJ
cord-018265-twp33bb6	188	18	number	number	NN
cord-018265-twp33bb6	188	19	of	of	IN
cord-018265-twp33bb6	188	20	serotypes	serotype	NNS
cord-018265-twp33bb6	188	21	,	,	,
cord-018265-twp33bb6	188	22	as	as	RB
cord-018265-twp33bb6	188	23	well	well	RB
cord-018265-twp33bb6	188	24	as	as	IN
cord-018265-twp33bb6	188	25	to	to	TO
cord-018265-twp33bb6	188	26	avoid	avoid	VB
cord-018265-twp33bb6	188	27	the	the	DT
cord-018265-twp33bb6	188	28	complexity	complexity	NN
cord-018265-twp33bb6	188	29	of	of	IN
cord-018265-twp33bb6	188	30	manufacturing	manufacture	VBG
cord-018265-twp33bb6	188	31	a	a	DT
cord-018265-twp33bb6	188	32	conjugate	conjugate	JJ
cord-018265-twp33bb6	188	33	vaccine	vaccine	NN
cord-018265-twp33bb6	188	34	[	[	-LRB-
cord-018265-twp33bb6	188	35	61	61	CD
cord-018265-twp33bb6	188	36	]	]	-RRB-
cord-018265-twp33bb6	188	37	.	.	.
cord-018265-twp33bb6	189	1	There	there	EX
cord-018265-twp33bb6	189	2	are	be	VBP
cord-018265-twp33bb6	189	3	different	different	JJ
cord-018265-twp33bb6	189	4	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	189	5	candidate	candidate	NN
cord-018265-twp33bb6	189	6	antigens	antigen	NNS
cord-018265-twp33bb6	189	7	,	,	,
cord-018265-twp33bb6	189	8	such	such	JJ
cord-018265-twp33bb6	189	9	as	as	IN
cord-018265-twp33bb6	189	10	the	the	DT
cord-018265-twp33bb6	189	11	pneumolysin	pneumolysin	NNP
cord-018265-twp33bb6	189	12	,	,	,
cord-018265-twp33bb6	189	13	neuraminidase	neuraminidase	NN
cord-018265-twp33bb6	189	14	,	,	,
cord-018265-twp33bb6	189	15	autolysin	autolysin	NNP
cord-018265-twp33bb6	189	16	,	,	,
cord-018265-twp33bb6	189	17	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	189	18	surface	surface	NN
cord-018265-twp33bb6	189	19	protein	protein	NN
cord-018265-twp33bb6	189	20	A	A	NNP
cord-018265-twp33bb6	189	21	(	(	-LRB-
cord-018265-twp33bb6	189	22	PspA	PspA	NNP
cord-018265-twp33bb6	189	23	)	)	-RRB-
cord-018265-twp33bb6	189	24	and	and	CC
cord-018265-twp33bb6	189	25	adhesin	adhesin	NNP
cord-018265-twp33bb6	189	26	A	A	NNP
cord-018265-twp33bb6	189	27	(	(	-LRB-
cord-018265-twp33bb6	189	28	PsaA	PsaA	NNP
cord-018265-twp33bb6	189	29	)	)	-RRB-
cord-018265-twp33bb6	189	30	,	,	,
cord-018265-twp33bb6	189	31	which	which	WDT
cord-018265-twp33bb6	189	32	are	be	VBP
cord-018265-twp33bb6	189	33	in	in	IN
cord-018265-twp33bb6	189	34	an	an	DT
cord-018265-twp33bb6	189	35	early	early	JJ
cord-018265-twp33bb6	189	36	phase	phase	NN
cord-018265-twp33bb6	189	37	of	of	IN
cord-018265-twp33bb6	189	38	clinical	clinical	JJ
cord-018265-twp33bb6	189	39	development	development	NN
cord-018265-twp33bb6	189	40	[	[	-LRB-
cord-018265-twp33bb6	189	41	1	1	CD
cord-018265-twp33bb6	189	42	]	]	-RRB-
cord-018265-twp33bb6	189	43	.	.	.
cord-018265-twp33bb6	190	1	In	in	IN
cord-018265-twp33bb6	190	2	addition	addition	NN
cord-018265-twp33bb6	190	3	,	,	,
cord-018265-twp33bb6	190	4	several	several	JJ
cord-018265-twp33bb6	190	5	promising	promising	JJ
cord-018265-twp33bb6	190	6	candidates	candidate	NNS
cord-018265-twp33bb6	190	7	have	have	VBP
cord-018265-twp33bb6	190	8	been	be	VBN
cord-018265-twp33bb6	190	9	identified	identify	VBN
cord-018265-twp33bb6	190	10	,	,	,
cord-018265-twp33bb6	190	11	which	which	WDT
cord-018265-twp33bb6	190	12	are	be	VBP
cord-018265-twp33bb6	190	13	currently	currently	RB
cord-018265-twp33bb6	190	14	being	be	VBG
cord-018265-twp33bb6	190	15	tested	test	VBN
cord-018265-twp33bb6	190	16	in	in	IN
cord-018265-twp33bb6	190	17	pre	pre	JJ
cord-018265-twp33bb6	190	18	-	-	JJ
cord-018265-twp33bb6	190	19	clinical	clinical	JJ
cord-018265-twp33bb6	190	20	experimental	experimental	JJ
cord-018265-twp33bb6	190	21	models	model	NNS
cord-018265-twp33bb6	190	22	[	[	-LRB-
cord-018265-twp33bb6	190	23	1	1	CD
cord-018265-twp33bb6	190	24	]	]	-RRB-
cord-018265-twp33bb6	190	25	.	.	.
cord-018265-twp33bb6	191	1	Among	among	IN
cord-018265-twp33bb6	191	2	them	-PRON-	PRP
cord-018265-twp33bb6	191	3	,	,	,
cord-018265-twp33bb6	191	4	the	the	DT
cord-018265-twp33bb6	191	5	two	two	CD
cord-018265-twp33bb6	191	6	iron	iron	NN
cord-018265-twp33bb6	191	7	uptake	uptake	NN
cord-018265-twp33bb6	191	8	ABC	ABC	NNP
cord-018265-twp33bb6	191	9	transporters	transporter	NNS
cord-018265-twp33bb6	191	10	of	of	IN
cord-018265-twp33bb6	191	11	S.	S.	NNP
cord-018265-twp33bb6	191	12	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	191	13	(	(	-LRB-
cord-018265-twp33bb6	191	14	PiaA	PiaA	NNP
cord-018265-twp33bb6	191	15	and	and	CC
cord-018265-twp33bb6	191	16	PiuA	PiuA	NNP
cord-018265-twp33bb6	191	17	)	)	-RRB-
cord-018265-twp33bb6	191	18	,	,	,
cord-018265-twp33bb6	191	19	which	which	WDT
cord-018265-twp33bb6	191	20	trigger	trigger	VBP
cord-018265-twp33bb6	191	21	protective	protective	JJ
cord-018265-twp33bb6	191	22	immunity	immunity	NN
cord-018265-twp33bb6	191	23	against	against	IN
cord-018265-twp33bb6	191	24	invasive	invasive	JJ
cord-018265-twp33bb6	191	25	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	191	26	disease	disease	NN
cord-018265-twp33bb6	191	27	in	in	IN
cord-018265-twp33bb6	191	28	mice	mouse	NNS
cord-018265-twp33bb6	191	29	.	.	.
cord-018265-twp33bb6	192	1	Through	through	IN
cord-018265-twp33bb6	192	2	the	the	DT
cord-018265-twp33bb6	192	3	screening	screening	NN
cord-018265-twp33bb6	192	4	of	of	IN
cord-018265-twp33bb6	192	5	S.	S.	NNP
cord-018265-twp33bb6	192	6	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	192	7	genomic	genomic	JJ
cord-018265-twp33bb6	192	8	expression	expression	NN
cord-018265-twp33bb6	192	9	libraries	library	NNS
cord-018265-twp33bb6	192	10	with	with	IN
cord-018265-twp33bb6	192	11	sera	sera	NNP
cord-018265-twp33bb6	192	12	from	from	IN
cord-018265-twp33bb6	192	13	convalescent	convalescent	JJ
cord-018265-twp33bb6	192	14	patients	patient	NNS
cord-018265-twp33bb6	192	15	,	,	,
cord-018265-twp33bb6	192	16	bacterial	bacterial	JJ
cord-018265-twp33bb6	192	17	surface	surface	NN
cord-018265-twp33bb6	192	18	proteins	protein	NNS
cord-018265-twp33bb6	192	19	were	be	VBD
cord-018265-twp33bb6	192	20	identified	identify	VBN
cord-018265-twp33bb6	192	21	(	(	-LRB-
cord-018265-twp33bb6	192	22	e.g.	e.g.	RB
cord-018265-twp33bb6	192	23	,	,	,
cord-018265-twp33bb6	192	24	BVH-3	BVH-3	NNP
cord-018265-twp33bb6	192	25	and	and	CC
cord-018265-twp33bb6	192	26	BVH-11	BVH-11	NNP
cord-018265-twp33bb6	192	27	)	)	-RRB-
cord-018265-twp33bb6	192	28	that	that	WDT
cord-018265-twp33bb6	192	29	promote	promote	VBP
cord-018265-twp33bb6	192	30	the	the	DT
cord-018265-twp33bb6	192	31	elicitation	elicitation	NN
cord-018265-twp33bb6	192	32	of	of	IN
cord-018265-twp33bb6	192	33	protective	protective	JJ
cord-018265-twp33bb6	192	34	anti	anti	JJ
cord-018265-twp33bb6	192	35	-	-	JJ
cord-018265-twp33bb6	192	36	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	192	37	antibodies	antibody	NNS
cord-018265-twp33bb6	192	38	in	in	IN
cord-018265-twp33bb6	192	39	mice	mouse	NNS
cord-018265-twp33bb6	192	40	[	[	-LRB-
cord-018265-twp33bb6	192	41	1	1	CD
cord-018265-twp33bb6	192	42	]	]	-RRB-
cord-018265-twp33bb6	192	43	.	.	.
cord-018265-twp33bb6	193	1	A	a	DT
cord-018265-twp33bb6	193	2	recombinant	recombinant	JJ
cord-018265-twp33bb6	193	3	hybrid	hybrid	NN
cord-018265-twp33bb6	193	4	protein	protein	NN
cord-018265-twp33bb6	193	5	,	,	,
cord-018265-twp33bb6	193	6	BVH3/11V	BVH3/11V	NNP
cord-018265-twp33bb6	193	7	,	,	,
cord-018265-twp33bb6	193	8	has	have	VBZ
cord-018265-twp33bb6	193	9	successfully	successfully	RB
cord-018265-twp33bb6	193	10	been	be	VBN
cord-018265-twp33bb6	193	11	tested	test	VBN
cord-018265-twp33bb6	193	12	in	in	IN
cord-018265-twp33bb6	193	13	toddlers	toddler	NNS
cord-018265-twp33bb6	193	14	and	and	CC
cord-018265-twp33bb6	193	15	elderly	elderly	JJ
cord-018265-twp33bb6	193	16	volunteers	volunteer	NNS
cord-018265-twp33bb6	193	17	.	.	.
cord-018265-twp33bb6	194	1	This	this	DT
cord-018265-twp33bb6	194	2	candidate	candidate	NN
cord-018265-twp33bb6	194	3	vaccine	vaccine	NN
cord-018265-twp33bb6	194	4	should	should	MD
cord-018265-twp33bb6	194	5	be	be	VB
cord-018265-twp33bb6	194	6	able	able	JJ
cord-018265-twp33bb6	194	7	to	to	TO
cord-018265-twp33bb6	194	8	trigger	trigger	VB
cord-018265-twp33bb6	194	9	serotype	serotype	NN
cord-018265-twp33bb6	194	10	-	-	HYPH
cord-018265-twp33bb6	194	11	independent	independent	JJ
cord-018265-twp33bb6	194	12	responses	response	NNS
cord-018265-twp33bb6	194	13	,	,	,
cord-018265-twp33bb6	194	14	since	since	IN
cord-018265-twp33bb6	194	15	the	the	DT
cord-018265-twp33bb6	194	16	BVH3	BVH3	NNP
cord-018265-twp33bb6	194	17	and	and	CC
cord-018265-twp33bb6	194	18	BVH11	BVH11	NNP
cord-018265-twp33bb6	194	19	antigens	antigen	NNS
cord-018265-twp33bb6	194	20	are	be	VBP
cord-018265-twp33bb6	194	21	common	common	JJ
cord-018265-twp33bb6	194	22	to	to	IN
cord-018265-twp33bb6	194	23	all	all	DT
cord-018265-twp33bb6	194	24	serotypes	serotype	NNS
cord-018265-twp33bb6	194	25	of	of	IN
cord-018265-twp33bb6	194	26	S.	S.	NNP
cord-018265-twp33bb6	194	27	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	194	28	.	.	.
cord-018265-twp33bb6	195	1	The	the	DT
cord-018265-twp33bb6	195	2	major	major	JJ
cord-018265-twp33bb6	195	3	obstacle	obstacle	NN
cord-018265-twp33bb6	195	4	for	for	IN
cord-018265-twp33bb6	195	5	developing	develop	VBG
cord-018265-twp33bb6	195	6	an	an	DT
cord-018265-twp33bb6	195	7	effective	effective	JJ
cord-018265-twp33bb6	195	8	vaccine	vaccine	NN
cord-018265-twp33bb6	195	9	against	against	IN
cord-018265-twp33bb6	195	10	H.	H.	NNP
cord-018265-twp33bb6	195	11	influenzae	influenzae	NN
cord-018265-twp33bb6	196	1	capsular	capsular	JJ
cord-018265-twp33bb6	196	2	PS	PS	NNP
cord-018265-twp33bb6	196	3	was	be	VBD
cord-018265-twp33bb6	196	4	related	relate	VBN
cord-018265-twp33bb6	196	5	to	to	IN
cord-018265-twp33bb6	196	6	the	the	DT
cord-018265-twp33bb6	196	7	inherently	inherently	RB
cord-018265-twp33bb6	196	8	poor	poor	JJ
cord-018265-twp33bb6	196	9	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	196	10	of	of	IN
cord-018265-twp33bb6	196	11	this	this	DT
cord-018265-twp33bb6	196	12	T	t	NN
cord-018265-twp33bb6	196	13	-	-	HYPH
cord-018265-twp33bb6	196	14	cell	cell	NN
cord-018265-twp33bb6	196	15	-	-	HYPH
cord-018265-twp33bb6	196	16	independent	independent	JJ
cord-018265-twp33bb6	196	17	antigen	antigen	NN
cord-018265-twp33bb6	196	18	.	.	.
cord-018265-twp33bb6	197	1	Antibody	antibody	NN
cord-018265-twp33bb6	197	2	responses	response	NNS
cord-018265-twp33bb6	197	3	against	against	IN
cord-018265-twp33bb6	197	4	PS	PS	NNP
cord-018265-twp33bb6	197	5	are	be	VBP
cord-018265-twp33bb6	197	6	age	age	NN
cord-018265-twp33bb6	197	7	-	-	HYPH
cord-018265-twp33bb6	197	8	related	relate	VBN
cord-018265-twp33bb6	197	9	,	,	,
cord-018265-twp33bb6	197	10	with	with	IN
cord-018265-twp33bb6	197	11	extremely	extremely	RB
cord-018265-twp33bb6	197	12	poor	poor	JJ
cord-018265-twp33bb6	197	13	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	197	14	in	in	IN
cord-018265-twp33bb6	197	15	infants	infant	NNS
cord-018265-twp33bb6	197	16	during	during	IN
cord-018265-twp33bb6	197	17	the	the	DT
cord-018265-twp33bb6	197	18	first	first	JJ
cord-018265-twp33bb6	197	19	18	18	CD
cord-018265-twp33bb6	197	20	months	month	NNS
cord-018265-twp33bb6	197	21	of	of	IN
cord-018265-twp33bb6	197	22	life	life	NN
cord-018265-twp33bb6	197	23	.	.	.
cord-018265-twp33bb6	198	1	Unfortunately	unfortunately	RB
cord-018265-twp33bb6	198	2	,	,	,
cord-018265-twp33bb6	198	3	this	this	DT
cord-018265-twp33bb6	198	4	age	age	NN
cord-018265-twp33bb6	198	5	group	group	NN
cord-018265-twp33bb6	198	6	exhibits	exhibit	VBZ
cord-018265-twp33bb6	198	7	the	the	DT
cord-018265-twp33bb6	198	8	highest	high	JJS
cord-018265-twp33bb6	198	9	risk	risk	NN
cord-018265-twp33bb6	198	10	for	for	IN
cord-018265-twp33bb6	198	11	invasive	invasive	JJ
cord-018265-twp33bb6	198	12	infections	infection	NNS
cord-018265-twp33bb6	198	13	caused	cause	VBN
cord-018265-twp33bb6	198	14	by	by	IN
cord-018265-twp33bb6	198	15	H.	H.	NNP
cord-018265-twp33bb6	198	16	influenzae	influenzae	NN
cord-018265-twp33bb6	198	17	.	.	.
cord-018265-twp33bb6	199	1	A	a	DT
cord-018265-twp33bb6	199	2	PS	PS	NNP
cord-018265-twp33bb6	199	3	-	-	HYPH
cord-018265-twp33bb6	199	4	based	base	VBN
cord-018265-twp33bb6	199	5	vaccine	vaccine	NN
cord-018265-twp33bb6	199	6	against	against	IN
cord-018265-twp33bb6	199	7	the	the	DT
cord-018265-twp33bb6	199	8	H.	H.	NNP
cord-018265-twp33bb6	199	9	influenzae	influenzae	NN
cord-018265-twp33bb6	199	10	type	type	NN
cord-018265-twp33bb6	199	11	b	b	NN
cord-018265-twp33bb6	199	12	(	(	-LRB-
cord-018265-twp33bb6	199	13	Hib	Hib	NNP
cord-018265-twp33bb6	199	14	)	)	-RRB-
cord-018265-twp33bb6	199	15	was	be	VBD
cord-018265-twp33bb6	199	16	licensed	license	VBN
cord-018265-twp33bb6	199	17	in	in	IN
cord-018265-twp33bb6	199	18	the	the	DT
cord-018265-twp33bb6	199	19	United	United	NNP
cord-018265-twp33bb6	199	20	States	States	NNP
cord-018265-twp33bb6	199	21	in	in	IN
cord-018265-twp33bb6	199	22	1985	1985	CD
cord-018265-twp33bb6	199	23	,	,	,
cord-018265-twp33bb6	199	24	for	for	IN
cord-018265-twp33bb6	199	25	children	child	NNS
cord-018265-twp33bb6	199	26	more	more	JJR
cord-018265-twp33bb6	199	27	than	than	IN
cord-018265-twp33bb6	199	28	18	18	CD
cord-018265-twp33bb6	199	29	months	month	NNS
cord-018265-twp33bb6	199	30	old	old	JJ
cord-018265-twp33bb6	199	31	[	[	-LRB-
cord-018265-twp33bb6	199	32	62	62	CD
cord-018265-twp33bb6	199	33	,	,	,
cord-018265-twp33bb6	199	34	63	63	CD
cord-018265-twp33bb6	199	35	]	]	-RRB-
cord-018265-twp33bb6	199	36	.	.	.
cord-018265-twp33bb6	200	1	The	the	DT
cord-018265-twp33bb6	200	2	protective	protective	JJ
cord-018265-twp33bb6	200	3	efficacy	efficacy	NN
cord-018265-twp33bb6	200	4	after	after	IN
cord-018265-twp33bb6	200	5	licensure	licensure	NN
cord-018265-twp33bb6	200	6	studies	study	NNS
cord-018265-twp33bb6	200	7	showed	show	VBD
cord-018265-twp33bb6	200	8	the	the	DT
cord-018265-twp33bb6	200	9	inefficacy	inefficacy	NN
cord-018265-twp33bb6	200	10	of	of	IN
cord-018265-twp33bb6	200	11	this	this	DT
cord-018265-twp33bb6	200	12	vaccine	vaccine	NN
cord-018265-twp33bb6	200	13	not	not	RB
cord-018265-twp33bb6	200	14	only	only	RB
cord-018265-twp33bb6	200	15	in	in	IN
cord-018265-twp33bb6	200	16	infants	infant	NNS
cord-018265-twp33bb6	200	17	,	,	,
cord-018265-twp33bb6	200	18	but	but	CC
cord-018265-twp33bb6	200	19	also	also	RB
cord-018265-twp33bb6	200	20	in	in	IN
cord-018265-twp33bb6	200	21	older	old	JJR
cord-018265-twp33bb6	200	22	children	child	NNS
cord-018265-twp33bb6	200	23	[	[	-LRB-
cord-018265-twp33bb6	200	24	64	64	CD
cord-018265-twp33bb6	200	25	]	]	-RRB-
cord-018265-twp33bb6	200	26	.	.	.
cord-018265-twp33bb6	201	1	This	this	DT
cord-018265-twp33bb6	201	2	problem	problem	NN
cord-018265-twp33bb6	201	3	was	be	VBD
cord-018265-twp33bb6	201	4	solved	solve	VBN
cord-018265-twp33bb6	201	5	by	by	IN
cord-018265-twp33bb6	201	6	the	the	DT
cord-018265-twp33bb6	201	7	generation	generation	NN
cord-018265-twp33bb6	201	8	of	of	IN
cord-018265-twp33bb6	201	9	a	a	DT
cord-018265-twp33bb6	201	10	conjugate	conjugate	JJ
cord-018265-twp33bb6	201	11	Hib	Hib	NNP
cord-018265-twp33bb6	201	12	vaccine	vaccine	NN
cord-018265-twp33bb6	201	13	.	.	.
cord-018265-twp33bb6	202	1	To	to	IN
cord-018265-twp33bb6	202	2	this	this	DT
cord-018265-twp33bb6	202	3	end	end	NN
cord-018265-twp33bb6	202	4	,	,	,
cord-018265-twp33bb6	202	5	the	the	DT
cord-018265-twp33bb6	202	6	Hib	Hib	NNP
cord-018265-twp33bb6	202	7	PS	PS	NNP
cord-018265-twp33bb6	202	8	(	(	-LRB-
cord-018265-twp33bb6	202	9	i.e.	i.e.	FW
cord-018265-twp33bb6	202	10	,	,	,
cord-018265-twp33bb6	202	11	polyribosylribitol	polyribosylribitol	JJ
cord-018265-twp33bb6	202	12	phosphate	phosphate	NN
cord-018265-twp33bb6	202	13	;	;	:
cord-018265-twp33bb6	202	14	PRP	PRP	NNP
cord-018265-twp33bb6	202	15	)	)	-RRB-
cord-018265-twp33bb6	202	16	was	be	VBD
cord-018265-twp33bb6	202	17	covalently	covalently	RB
cord-018265-twp33bb6	202	18	linked	link	VBN
cord-018265-twp33bb6	202	19	to	to	IN
cord-018265-twp33bb6	202	20	an	an	DT
cord-018265-twp33bb6	202	21	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	202	22	carrier	carrier	NN
cord-018265-twp33bb6	202	23	protein	protein	NN
cord-018265-twp33bb6	202	24	,	,	,
cord-018265-twp33bb6	202	25	thereby	thereby	RB
cord-018265-twp33bb6	202	26	leading	lead	VBG
cord-018265-twp33bb6	202	27	to	to	IN
cord-018265-twp33bb6	202	28	T	t	NN
cord-018265-twp33bb6	202	29	-	-	HYPH
cord-018265-twp33bb6	202	30	cell	cell	NN
cord-018265-twp33bb6	202	31	-	-	HYPH
cord-018265-twp33bb6	202	32	dependent	dependent	JJ
cord-018265-twp33bb6	202	33	responses	response	NNS
cord-018265-twp33bb6	202	34	against	against	IN
cord-018265-twp33bb6	202	35	the	the	DT
cord-018265-twp33bb6	202	36	PS	PS	NNP
cord-018265-twp33bb6	202	37	.	.	.
cord-018265-twp33bb6	203	1	Different	different	JJ
cord-018265-twp33bb6	203	2	conjugate	conjugate	NN
cord-018265-twp33bb6	203	3	Hib	Hib	NNP
cord-018265-twp33bb6	203	4	vaccines	vaccine	NNS
cord-018265-twp33bb6	203	5	currently	currently	RB
cord-018265-twp33bb6	203	6	exist	exist	VBP
cord-018265-twp33bb6	203	7	.	.	.
cord-018265-twp33bb6	204	1	These	these	DT
cord-018265-twp33bb6	204	2	vaccines	vaccine	NNS
cord-018265-twp33bb6	204	3	are	be	VBP
cord-018265-twp33bb6	204	4	HbOC	hboc	NN
cord-018265-twp33bb6	204	5	,	,	,
cord-018265-twp33bb6	204	6	PRP	PRP	NNP
cord-018265-twp33bb6	204	7	-	-	HYPH
cord-018265-twp33bb6	204	8	T	T	NNP
cord-018265-twp33bb6	204	9	and	and	CC
cord-018265-twp33bb6	204	10	PRP	PRP	NNP
cord-018265-twp33bb6	204	11	-	-	HYPH
cord-018265-twp33bb6	204	12	OMP	OMP	NNP
cord-018265-twp33bb6	204	13	,	,	,
cord-018265-twp33bb6	204	14	which	which	WDT
cord-018265-twp33bb6	204	15	make	make	VBP
cord-018265-twp33bb6	204	16	use	use	NN
cord-018265-twp33bb6	204	17	of	of	IN
cord-018265-twp33bb6	204	18	the	the	DT
cord-018265-twp33bb6	204	19	mutant	mutant	JJ
cord-018265-twp33bb6	204	20	diphtheria	diphtheria	NN
cord-018265-twp33bb6	204	21	toxin	toxin	NN
cord-018265-twp33bb6	204	22	CRM197	CRM197	NNP
cord-018265-twp33bb6	204	23	,	,	,
cord-018265-twp33bb6	204	24	the	the	DT
cord-018265-twp33bb6	204	25	tetanus	tetanus	NN
cord-018265-twp33bb6	204	26	toxoid	toxoid	NN
cord-018265-twp33bb6	204	27	and	and	CC
cord-018265-twp33bb6	204	28	the	the	DT
cord-018265-twp33bb6	204	29	outer	outer	JJ
cord-018265-twp33bb6	204	30	membrane	membrane	NN
cord-018265-twp33bb6	204	31	protein	protein	NN
cord-018265-twp33bb6	204	32	from	from	IN
cord-018265-twp33bb6	204	33	group	group	NN
cord-018265-twp33bb6	204	34	B	B	NNP
cord-018265-twp33bb6	204	35	N.	N.	NNP
cord-018265-twp33bb6	204	36	meningitidis	meningitidis	NN
cord-018265-twp33bb6	204	37	as	as	IN
cord-018265-twp33bb6	204	38	carriers	carrier	NNS
cord-018265-twp33bb6	204	39	,	,	,
cord-018265-twp33bb6	204	40	respectively	respectively	RB
cord-018265-twp33bb6	204	41	.	.	.
cord-018265-twp33bb6	205	1	All	all	DT
cord-018265-twp33bb6	205	2	of	of	IN
cord-018265-twp33bb6	205	3	them	-PRON-	PRP
cord-018265-twp33bb6	205	4	trigger	trigger	VBP
cord-018265-twp33bb6	205	5	similar	similar	JJ
cord-018265-twp33bb6	205	6	immune	immune	JJ
cord-018265-twp33bb6	205	7	responses	response	NNS
cord-018265-twp33bb6	205	8	at	at	IN
cord-018265-twp33bb6	205	9	the	the	DT
cord-018265-twp33bb6	205	10	recommended	recommend	VBN
cord-018265-twp33bb6	205	11	doses	dose	NNS
cord-018265-twp33bb6	205	12	.	.	.
cord-018265-twp33bb6	206	1	However	however	RB
cord-018265-twp33bb6	206	2	,	,	,
cord-018265-twp33bb6	206	3	the	the	DT
cord-018265-twp33bb6	206	4	dynamic	dynamic	NN
cord-018265-twp33bb6	206	5	of	of	IN
cord-018265-twp33bb6	206	6	the	the	DT
cord-018265-twp33bb6	206	7	elicited	elicit	VBN
cord-018265-twp33bb6	206	8	response	response	NN
cord-018265-twp33bb6	206	9	may	may	MD
cord-018265-twp33bb6	206	10	vary	vary	VB
cord-018265-twp33bb6	206	11	for	for	IN
cord-018265-twp33bb6	206	12	each	each	DT
cord-018265-twp33bb6	206	13	of	of	IN
cord-018265-twp33bb6	206	14	them	-PRON-	PRP
cord-018265-twp33bb6	206	15	[	[	-LRB-
cord-018265-twp33bb6	206	16	65	65	CD
cord-018265-twp33bb6	206	17	,	,	,
cord-018265-twp33bb6	206	18	66	66	CD
cord-018265-twp33bb6	206	19	]	]	-RRB-
cord-018265-twp33bb6	206	20	.	.	.
cord-018265-twp33bb6	207	1	Efficacy	efficacy	NN
cord-018265-twp33bb6	207	2	studies	study	NNS
cord-018265-twp33bb6	207	3	of	of	IN
cord-018265-twp33bb6	207	4	these	these	DT
cord-018265-twp33bb6	207	5	vaccines	vaccine	NNS
cord-018265-twp33bb6	207	6	showed	show	VBD
cord-018265-twp33bb6	207	7	that	that	IN
cord-018265-twp33bb6	207	8	they	-PRON-	PRP
cord-018265-twp33bb6	207	9	confer	confer	VBP
cord-018265-twp33bb6	207	10	protection	protection	NN
cord-018265-twp33bb6	207	11	not	not	RB
cord-018265-twp33bb6	207	12	only	only	RB
cord-018265-twp33bb6	207	13	against	against	IN
cord-018265-twp33bb6	207	14	meningitis	meningitis	NN
cord-018265-twp33bb6	207	15	,	,	,
cord-018265-twp33bb6	207	16	but	but	CC
cord-018265-twp33bb6	207	17	also	also	RB
cord-018265-twp33bb6	207	18	against	against	IN
cord-018265-twp33bb6	207	19	pneumonia	pneumonia	NN
cord-018265-twp33bb6	207	20	[	[	-LRB-
cord-018265-twp33bb6	207	21	67	67	CD
cord-018265-twp33bb6	207	22	]	]	-RRB-
cord-018265-twp33bb6	207	23	[	[	-LRB-
cord-018265-twp33bb6	207	24	68	68	CD
cord-018265-twp33bb6	207	25	]	]	-RRB-
cord-018265-twp33bb6	207	26	[	[	-LRB-
cord-018265-twp33bb6	207	27	69	69	CD
cord-018265-twp33bb6	207	28	]	]	-RRB-
cord-018265-twp33bb6	207	29	.	.	.
cord-018265-twp33bb6	208	1	Although	although	IN
cord-018265-twp33bb6	208	2	Hib	Hib	NNP
cord-018265-twp33bb6	208	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	208	4	are	be	VBP
cord-018265-twp33bb6	208	5	highly	highly	RB
cord-018265-twp33bb6	208	6	effective	effective	JJ
cord-018265-twp33bb6	208	7	,	,	,
cord-018265-twp33bb6	208	8	their	-PRON-	PRP$
cord-018265-twp33bb6	208	9	cost	cost	NN
cord-018265-twp33bb6	208	10	is	be	VBZ
cord-018265-twp33bb6	208	11	still	still	RB
cord-018265-twp33bb6	208	12	prohibitive	prohibitive	JJ
cord-018265-twp33bb6	208	13	for	for	IN
cord-018265-twp33bb6	208	14	the	the	DT
cord-018265-twp33bb6	208	15	world	world	NN
cord-018265-twp33bb6	208	16	's	's	POS
cord-018265-twp33bb6	208	17	poorest	poor	JJS
cord-018265-twp33bb6	208	18	nations	nation	NNS
cord-018265-twp33bb6	208	19	.	.	.
cord-018265-twp33bb6	209	1	However	however	RB
cord-018265-twp33bb6	209	2	,	,	,
cord-018265-twp33bb6	209	3	with	with	IN
cord-018265-twp33bb6	209	4	the	the	DT
cord-018265-twp33bb6	209	5	establishment	establishment	NN
cord-018265-twp33bb6	209	6	of	of	IN
cord-018265-twp33bb6	209	7	the	the	DT
cord-018265-twp33bb6	209	8	Global	Global	NNP
cord-018265-twp33bb6	209	9	Alliance	Alliance	NNP
cord-018265-twp33bb6	209	10	for	for	IN
cord-018265-twp33bb6	209	11	Vaccines	Vaccines	NNPS
cord-018265-twp33bb6	209	12	and	and	CC
cord-018265-twp33bb6	209	13	Immunization	Immunization	NNP
cord-018265-twp33bb6	209	14	(	(	-LRB-
cord-018265-twp33bb6	209	15	GAVI	GAVI	NNP
cord-018265-twp33bb6	209	16	)	)	-RRB-
cord-018265-twp33bb6	209	17	,	,	,
cord-018265-twp33bb6	209	18	we	-PRON-	PRP
cord-018265-twp33bb6	209	19	have	have	VBP
cord-018265-twp33bb6	209	20	moved	move	VBN
cord-018265-twp33bb6	209	21	consistently	consistently	RB
cord-018265-twp33bb6	209	22	ahead	ahead	RB
cord-018265-twp33bb6	209	23	in	in	IN
cord-018265-twp33bb6	209	24	making	make	VBG
cord-018265-twp33bb6	209	25	them	-PRON-	PRP
cord-018265-twp33bb6	209	26	also	also	RB
cord-018265-twp33bb6	209	27	available	available	JJ
cord-018265-twp33bb6	209	28	for	for	IN
cord-018265-twp33bb6	209	29	developing	develop	VBG
cord-018265-twp33bb6	209	30	countries	country	NNS
cord-018265-twp33bb6	209	31	.	.	.
cord-018265-twp33bb6	210	1	GAVI	GAVI	NNP
cord-018265-twp33bb6	210	2	has	have	VBZ
cord-018265-twp33bb6	210	3	approved	approve	VBN
cord-018265-twp33bb6	210	4	the	the	DT
cord-018265-twp33bb6	210	5	establishment	establishment	NN
cord-018265-twp33bb6	210	6	of	of	IN
cord-018265-twp33bb6	210	7	a	a	DT
cord-018265-twp33bb6	210	8	Hib	Hib	NNP
cord-018265-twp33bb6	210	9	initiative	initiative	NN
cord-018265-twp33bb6	210	10	to	to	TO
cord-018265-twp33bb6	210	11	support	support	VB
cord-018265-twp33bb6	210	12	countries	country	NNS
cord-018265-twp33bb6	210	13	wishing	wish	VBG
cord-018265-twp33bb6	210	14	to	to	TO
cord-018265-twp33bb6	210	15	sustain	sustain	VB
cord-018265-twp33bb6	210	16	Hib	Hib	NNP
cord-018265-twp33bb6	210	17	vaccination	vaccination	NN
cord-018265-twp33bb6	210	18	,	,	,
cord-018265-twp33bb6	210	19	as	as	RB
cord-018265-twp33bb6	210	20	well	well	RB
cord-018265-twp33bb6	210	21	as	as	IN
cord-018265-twp33bb6	210	22	those	those	DT
cord-018265-twp33bb6	210	23	exploring	explore	VBG
cord-018265-twp33bb6	210	24	whether	whether	IN
cord-018265-twp33bb6	210	25	their	-PRON-	PRP$
cord-018265-twp33bb6	210	26	introduction	introduction	NN
cord-018265-twp33bb6	210	27	could	could	MD
cord-018265-twp33bb6	210	28	be	be	VB
cord-018265-twp33bb6	210	29	considered	consider	VBN
cord-018265-twp33bb6	210	30	a	a	DT
cord-018265-twp33bb6	210	31	priority	priority	NN
cord-018265-twp33bb6	210	32	in	in	IN
cord-018265-twp33bb6	210	33	the	the	DT
cord-018265-twp33bb6	210	34	near	near	JJ
cord-018265-twp33bb6	210	35	future	future	NN
cord-018265-twp33bb6	210	36	.	.	.
cord-018265-twp33bb6	211	1	Although	although	IN
cord-018265-twp33bb6	211	2	the	the	DT
cord-018265-twp33bb6	211	3	introduction	introduction	NN
cord-018265-twp33bb6	211	4	of	of	IN
cord-018265-twp33bb6	211	5	conjugated	conjugated	JJ
cord-018265-twp33bb6	211	6	PS	PS	NNP
cord-018265-twp33bb6	211	7	vaccines	vaccine	NNS
cord-018265-twp33bb6	211	8	has	have	VBZ
cord-018265-twp33bb6	211	9	significantly	significantly	RB
cord-018265-twp33bb6	211	10	decreased	decrease	VBN
cord-018265-twp33bb6	211	11	the	the	DT
cord-018265-twp33bb6	211	12	prevalence	prevalence	NN
cord-018265-twp33bb6	211	13	of	of	IN
cord-018265-twp33bb6	211	14	invasive	invasive	JJ
cord-018265-twp33bb6	211	15	Hib	Hib	NNP
cord-018265-twp33bb6	211	16	disease	disease	NN
cord-018265-twp33bb6	211	17	,	,	,
cord-018265-twp33bb6	211	18	paediatric	paediatric	JJ
cord-018265-twp33bb6	211	19	infections	infection	NNS
cord-018265-twp33bb6	211	20	due	due	JJ
cord-018265-twp33bb6	211	21	to	to	IN
cord-018265-twp33bb6	211	22	non	non	JJ
cord-018265-twp33bb6	211	23	typeable	typeable	JJ
cord-018265-twp33bb6	211	24	H.	h.	NN
cord-018265-twp33bb6	211	25	influenzae	influenzae	NN
cord-018265-twp33bb6	211	26	(	(	-LRB-
cord-018265-twp33bb6	211	27	NTHi	NTHi	NNS
cord-018265-twp33bb6	211	28	)	)	-RRB-
cord-018265-twp33bb6	211	29	are	be	VBP
cord-018265-twp33bb6	211	30	still	still	RB
cord-018265-twp33bb6	211	31	highly	highly	RB
cord-018265-twp33bb6	211	32	prevalent	prevalent	JJ
cord-018265-twp33bb6	211	33	.	.	.
cord-018265-twp33bb6	212	1	NTHi	NTHi	NNP
cord-018265-twp33bb6	212	2	is	be	VBZ
cord-018265-twp33bb6	212	3	most	most	RBS
cord-018265-twp33bb6	212	4	often	often	RB
cord-018265-twp33bb6	212	5	associated	associate	VBN
cord-018265-twp33bb6	212	6	with	with	IN
cord-018265-twp33bb6	212	7	otitis	otitis	NN
cord-018265-twp33bb6	212	8	media	medium	NNS
cord-018265-twp33bb6	212	9	,	,	,
cord-018265-twp33bb6	212	10	sinusitis	sinusitis	NN
cord-018265-twp33bb6	212	11	and	and	CC
cord-018265-twp33bb6	212	12	bronchitis	bronchitis	NN
cord-018265-twp33bb6	212	13	.	.	.
cord-018265-twp33bb6	213	1	In	in	IN
cord-018265-twp33bb6	213	2	addition	addition	NN
cord-018265-twp33bb6	213	3	,	,	,
cord-018265-twp33bb6	213	4	NTHi	NTHi	NNP
cord-018265-twp33bb6	213	5	is	be	VBZ
cord-018265-twp33bb6	213	6	an	an	DT
cord-018265-twp33bb6	213	7	important	important	JJ
cord-018265-twp33bb6	213	8	cause	cause	NN
cord-018265-twp33bb6	213	9	of	of	IN
cord-018265-twp33bb6	213	10	lower	low	JJR
cord-018265-twp33bb6	213	11	respiratory	respiratory	JJ
cord-018265-twp33bb6	213	12	infection	infection	NN
cord-018265-twp33bb6	213	13	in	in	IN
cord-018265-twp33bb6	213	14	adults	adult	NNS
cord-018265-twp33bb6	213	15	with	with	IN
cord-018265-twp33bb6	213	16	chronic	chronic	JJ
cord-018265-twp33bb6	213	17	obstructive	obstructive	JJ
cord-018265-twp33bb6	213	18	pulmonary	pulmonary	JJ
cord-018265-twp33bb6	213	19	disease	disease	NN
cord-018265-twp33bb6	213	20	(	(	-LRB-
cord-018265-twp33bb6	213	21	COPD	COPD	NNP
cord-018265-twp33bb6	213	22	)	)	-RRB-
cord-018265-twp33bb6	213	23	.	.	.
cord-018265-twp33bb6	214	1	Thus	thus	RB
cord-018265-twp33bb6	214	2	,	,	,
cord-018265-twp33bb6	214	3	the	the	DT
cord-018265-twp33bb6	214	4	development	development	NN
cord-018265-twp33bb6	214	5	of	of	IN
cord-018265-twp33bb6	214	6	a	a	DT
cord-018265-twp33bb6	214	7	vaccine	vaccine	NN
cord-018265-twp33bb6	214	8	against	against	IN
cord-018265-twp33bb6	214	9	NTHi	NTHi	NNP
cord-018265-twp33bb6	214	10	is	be	VBZ
cord-018265-twp33bb6	214	11	considered	consider	VBN
cord-018265-twp33bb6	214	12	an	an	DT
cord-018265-twp33bb6	214	13	important	important	JJ
cord-018265-twp33bb6	214	14	goal	goal	NN
cord-018265-twp33bb6	214	15	in	in	IN
cord-018265-twp33bb6	214	16	public	public	JJ
cord-018265-twp33bb6	214	17	health	health	NN
cord-018265-twp33bb6	214	18	.	.	.
cord-018265-twp33bb6	215	1	In	in	IN
cord-018265-twp33bb6	215	2	contrast	contrast	NN
cord-018265-twp33bb6	215	3	to	to	IN
cord-018265-twp33bb6	215	4	Hib	Hib	NNP
cord-018265-twp33bb6	215	5	,	,	,
cord-018265-twp33bb6	215	6	vaccines	vaccine	NNS
cord-018265-twp33bb6	215	7	against	against	IN
cord-018265-twp33bb6	215	8	the	the	DT
cord-018265-twp33bb6	215	9	non	non	JJ
cord-018265-twp33bb6	215	10	-	-	JJ
cord-018265-twp33bb6	215	11	encapsulated	encapsulated	JJ
cord-018265-twp33bb6	215	12	NTHi	NTHi	NNS
cord-018265-twp33bb6	215	13	strains	strain	NNS
cord-018265-twp33bb6	215	14	must	must	MD
cord-018265-twp33bb6	215	15	be	be	VB
cord-018265-twp33bb6	215	16	directed	direct	VBN
cord-018265-twp33bb6	215	17	against	against	IN
cord-018265-twp33bb6	215	18	alternative	alternative	JJ
cord-018265-twp33bb6	215	19	virulence	virulence	NN
cord-018265-twp33bb6	215	20	factors	factor	NNS
cord-018265-twp33bb6	215	21	.	.	.
cord-018265-twp33bb6	216	1	The	the	DT
cord-018265-twp33bb6	216	2	lipoproteins	lipoprotein	NNS
cord-018265-twp33bb6	216	3	D	d	NN
cord-018265-twp33bb6	216	4	and	and	CC
cord-018265-twp33bb6	216	5	P6	p6	NN
cord-018265-twp33bb6	216	6	are	be	VBP
cord-018265-twp33bb6	216	7	widely	widely	RB
cord-018265-twp33bb6	216	8	distributed	distribute	VBN
cord-018265-twp33bb6	216	9	and	and	CC
cord-018265-twp33bb6	216	10	antigenically	antigenically	RB
cord-018265-twp33bb6	216	11	conserved	conserve	VBN
cord-018265-twp33bb6	216	12	among	among	IN
cord-018265-twp33bb6	216	13	H.	h.	NN
cord-018265-twp33bb6	216	14	influenzae	influenzae	NN
cord-018265-twp33bb6	216	15	strains	strain	NNS
cord-018265-twp33bb6	216	16	,	,	,
cord-018265-twp33bb6	216	17	and	and	CC
cord-018265-twp33bb6	216	18	also	also	RB
cord-018265-twp33bb6	216	19	trigger	trigger	VB
cord-018265-twp33bb6	216	20	the	the	DT
cord-018265-twp33bb6	216	21	elicitation	elicitation	NN
cord-018265-twp33bb6	216	22	of	of	IN
cord-018265-twp33bb6	216	23	protective	protective	JJ
cord-018265-twp33bb6	216	24	immunity	immunity	NN
cord-018265-twp33bb6	216	25	in	in	IN
cord-018265-twp33bb6	216	26	animals	animal	NNS
cord-018265-twp33bb6	216	27	vaccinated	vaccinate	VBN
cord-018265-twp33bb6	216	28	by	by	IN
cord-018265-twp33bb6	216	29	mucosal	mucosal	JJ
cord-018265-twp33bb6	216	30	route	route	NN
cord-018265-twp33bb6	216	31	[	[	-LRB-
cord-018265-twp33bb6	216	32	70	70	CD
cord-018265-twp33bb6	216	33	]	]	-RRB-
cord-018265-twp33bb6	217	1	[	[	-LRB-
cord-018265-twp33bb6	217	2	71	71	CD
cord-018265-twp33bb6	217	3	]	]	-RRB-
cord-018265-twp33bb6	218	1	[	[	-LRB-
cord-018265-twp33bb6	218	2	72	72	CD
cord-018265-twp33bb6	218	3	]	]	-RRB-
cord-018265-twp33bb6	218	4	[	[	-LRB-
cord-018265-twp33bb6	218	5	73	73	CD
cord-018265-twp33bb6	218	6	]	]	-RRB-
cord-018265-twp33bb6	218	7	.	.	.
cord-018265-twp33bb6	219	1	Thus	thus	RB
cord-018265-twp33bb6	219	2	,	,	,
cord-018265-twp33bb6	219	3	their	-PRON-	PRP$
cord-018265-twp33bb6	219	4	incorporation	incorporation	NN
cord-018265-twp33bb6	219	5	in	in	IN
cord-018265-twp33bb6	219	6	vaccine	vaccine	NN
cord-018265-twp33bb6	219	7	candidates	candidate	NNS
cord-018265-twp33bb6	219	8	might	may	MD
cord-018265-twp33bb6	219	9	facilitate	facilitate	VB
cord-018265-twp33bb6	219	10	the	the	DT
cord-018265-twp33bb6	219	11	generation	generation	NN
cord-018265-twp33bb6	219	12	of	of	IN
cord-018265-twp33bb6	219	13	a	a	DT
cord-018265-twp33bb6	219	14	universal	universal	JJ
cord-018265-twp33bb6	219	15	vaccine	vaccine	NN
cord-018265-twp33bb6	219	16	against	against	IN
cord-018265-twp33bb6	219	17	all	all	DT
cord-018265-twp33bb6	219	18	typeable	typeable	JJ
cord-018265-twp33bb6	219	19	and	and	CC
cord-018265-twp33bb6	219	20	non	non	JJ
cord-018265-twp33bb6	219	21	typeable	typeable	JJ
cord-018265-twp33bb6	219	22	H.	h.	NN
cord-018265-twp33bb6	219	23	influenzae	influenzae	NN
cord-018265-twp33bb6	219	24	.	.	.
cord-018265-twp33bb6	220	1	Even	even	RB
cord-018265-twp33bb6	220	2	in	in	IN
cord-018265-twp33bb6	220	3	the	the	DT
cord-018265-twp33bb6	220	4	age	age	NN
cord-018265-twp33bb6	220	5	of	of	IN
cord-018265-twp33bb6	220	6	vaccine	vaccine	NN
cord-018265-twp33bb6	220	7	availability	availability	NN
cord-018265-twp33bb6	220	8	,	,	,
cord-018265-twp33bb6	220	9	B.	B.	NNP
cord-018265-twp33bb6	220	10	pertussis	pertussis	NN
cord-018265-twp33bb6	220	11	continues	continue	VBZ
cord-018265-twp33bb6	220	12	to	to	TO
cord-018265-twp33bb6	220	13	be	be	VB
cord-018265-twp33bb6	220	14	a	a	DT
cord-018265-twp33bb6	220	15	major	major	JJ
cord-018265-twp33bb6	220	16	cause	cause	NN
cord-018265-twp33bb6	220	17	of	of	IN
cord-018265-twp33bb6	220	18	childhood	childhood	NN
cord-018265-twp33bb6	220	19	morbidity	morbidity	NN
cord-018265-twp33bb6	220	20	and	and	CC
cord-018265-twp33bb6	220	21	mortality	mortality	NN
cord-018265-twp33bb6	220	22	(	(	-LRB-
cord-018265-twp33bb6	220	23	i.e.	i.e.	FW
cord-018265-twp33bb6	220	24	,	,	,
cord-018265-twp33bb6	220	25	approximately	approximately	RB
cord-018265-twp33bb6	220	26	50	50	CD
cord-018265-twp33bb6	220	27	million	million	CD
cord-018265-twp33bb6	220	28	cases	case	NNS
cord-018265-twp33bb6	220	29	and	and	CC
cord-018265-twp33bb6	220	30	300,000	300,000	CD
cord-018265-twp33bb6	220	31	deaths	death	NNS
cord-018265-twp33bb6	220	32	occur	occur	VBP
cord-018265-twp33bb6	220	33	annually	annually	RB
cord-018265-twp33bb6	220	34	worldwide	worldwide	RB
cord-018265-twp33bb6	220	35	)	)	-RRB-
cord-018265-twp33bb6	220	36	.	.	.
cord-018265-twp33bb6	221	1	Since	since	IN
cord-018265-twp33bb6	221	2	the	the	DT
cord-018265-twp33bb6	221	3	late	late	JJ
cord-018265-twp33bb6	221	4	1940s	1940	NNS
cord-018265-twp33bb6	221	5	,	,	,
cord-018265-twp33bb6	221	6	the	the	DT
cord-018265-twp33bb6	221	7	incidence	incidence	NN
cord-018265-twp33bb6	221	8	of	of	IN
cord-018265-twp33bb6	221	9	whooping	whooping	JJ
cord-018265-twp33bb6	221	10	cough	cough	NN
cord-018265-twp33bb6	221	11	has	have	VBZ
cord-018265-twp33bb6	221	12	dramatically	dramatically	RB
cord-018265-twp33bb6	221	13	decreased	decrease	VBN
cord-018265-twp33bb6	221	14	in	in	IN
cord-018265-twp33bb6	221	15	most	most	JJS
cord-018265-twp33bb6	221	16	developed	develop	VBN
cord-018265-twp33bb6	221	17	countries	country	NNS
cord-018265-twp33bb6	221	18	,	,	,
cord-018265-twp33bb6	221	19	as	as	IN
cord-018265-twp33bb6	221	20	a	a	DT
cord-018265-twp33bb6	221	21	result	result	NN
cord-018265-twp33bb6	221	22	of	of	IN
cord-018265-twp33bb6	221	23	widespread	widespread	JJ
cord-018265-twp33bb6	221	24	immunization	immunization	NN
cord-018265-twp33bb6	221	25	.	.	.
cord-018265-twp33bb6	222	1	The	the	DT
cord-018265-twp33bb6	222	2	first	first	JJ
cord-018265-twp33bb6	222	3	vaccine	vaccine	NN
cord-018265-twp33bb6	222	4	formulations	formulation	NNS
cord-018265-twp33bb6	222	5	,	,	,
cord-018265-twp33bb6	222	6	which	which	WDT
cord-018265-twp33bb6	222	7	are	be	VBP
cord-018265-twp33bb6	222	8	still	still	RB
cord-018265-twp33bb6	222	9	in	in	IN
cord-018265-twp33bb6	222	10	use	use	NN
cord-018265-twp33bb6	222	11	,	,	,
cord-018265-twp33bb6	222	12	consist	consist	VBP
cord-018265-twp33bb6	222	13	of	of	IN
cord-018265-twp33bb6	222	14	preparations	preparation	NNS
cord-018265-twp33bb6	222	15	based	base	VBN
cord-018265-twp33bb6	222	16	on	on	IN
cord-018265-twp33bb6	222	17	killed	kill	VBN
cord-018265-twp33bb6	222	18	B.	B.	NNP
cord-018265-twp33bb6	222	19	pertussis	pertussis	NN
cord-018265-twp33bb6	222	20	.	.	.
cord-018265-twp33bb6	223	1	The	the	DT
cord-018265-twp33bb6	223	2	frequent	frequent	JJ
cord-018265-twp33bb6	223	3	incidence	incidence	NN
cord-018265-twp33bb6	223	4	of	of	IN
cord-018265-twp33bb6	223	5	minor	minor	JJ
cord-018265-twp33bb6	223	6	adverse	adverse	JJ
cord-018265-twp33bb6	223	7	effects	effect	NNS
cord-018265-twp33bb6	223	8	(	(	-LRB-
cord-018265-twp33bb6	223	9	e.g.	e.g.	RB
cord-018265-twp33bb6	223	10	,	,	,
cord-018265-twp33bb6	223	11	fever	fever	NN
cord-018265-twp33bb6	223	12	,	,	,
cord-018265-twp33bb6	223	13	protracted	protracted	JJ
cord-018265-twp33bb6	223	14	crying	crying	NN
cord-018265-twp33bb6	223	15	and	and	CC
cord-018265-twp33bb6	223	16	local	local	JJ
cord-018265-twp33bb6	223	17	erythematous	erythematous	JJ
cord-018265-twp33bb6	223	18	reactions	reaction	NNS
cord-018265-twp33bb6	223	19	)	)	-RRB-
cord-018265-twp33bb6	223	20	,	,	,
cord-018265-twp33bb6	223	21	as	as	RB
cord-018265-twp33bb6	223	22	well	well	RB
cord-018265-twp33bb6	223	23	as	as	IN
cord-018265-twp33bb6	223	24	concerns	concern	NNS
cord-018265-twp33bb6	223	25	raised	raise	VBN
cord-018265-twp33bb6	223	26	by	by	IN
cord-018265-twp33bb6	223	27	reports	report	NNS
cord-018265-twp33bb6	223	28	of	of	IN
cord-018265-twp33bb6	223	29	serious	serious	JJ
cord-018265-twp33bb6	223	30	neurological	neurological	JJ
cord-018265-twp33bb6	223	31	side	side	NN
cord-018265-twp33bb6	223	32	-	-	HYPH
cord-018265-twp33bb6	223	33	effects	effect	NNS
cord-018265-twp33bb6	223	34	,	,	,
cord-018265-twp33bb6	223	35	resulted	result	VBD
cord-018265-twp33bb6	223	36	in	in	IN
cord-018265-twp33bb6	223	37	a	a	DT
cord-018265-twp33bb6	223	38	decline	decline	NN
cord-018265-twp33bb6	223	39	in	in	IN
cord-018265-twp33bb6	223	40	vaccine	vaccine	NN
cord-018265-twp33bb6	223	41	acceptance	acceptance	NN
cord-018265-twp33bb6	223	42	and	and	CC
cord-018265-twp33bb6	223	43	use	use	VB
cord-018265-twp33bb6	223	44	[	[	-LRB-
cord-018265-twp33bb6	223	45	74	74	CD
cord-018265-twp33bb6	223	46	]	]	-RRB-
cord-018265-twp33bb6	223	47	.	.	.
cord-018265-twp33bb6	224	1	This	this	DT
cord-018265-twp33bb6	224	2	in	in	IN
cord-018265-twp33bb6	224	3	turn	turn	NN
cord-018265-twp33bb6	224	4	led	lead	VBD
cord-018265-twp33bb6	224	5	to	to	IN
cord-018265-twp33bb6	224	6	a	a	DT
cord-018265-twp33bb6	224	7	re	re	NN
cord-018265-twp33bb6	224	8	-	-	NN
cord-018265-twp33bb6	224	9	emergence	emergence	NN
cord-018265-twp33bb6	224	10	of	of	IN
cord-018265-twp33bb6	224	11	whooping	whooping	JJ
cord-018265-twp33bb6	224	12	cough	cough	NN
cord-018265-twp33bb6	224	13	and	and	CC
cord-018265-twp33bb6	224	14	its	-PRON-	PRP$
cord-018265-twp33bb6	224	15	complications	complication	NNS
cord-018265-twp33bb6	224	16	.	.	.
cord-018265-twp33bb6	225	1	This	this	DT
cord-018265-twp33bb6	225	2	serious	serious	JJ
cord-018265-twp33bb6	225	3	problem	problem	NN
cord-018265-twp33bb6	225	4	prompted	prompt	VBD
cord-018265-twp33bb6	225	5	the	the	DT
cord-018265-twp33bb6	225	6	development	development	NN
cord-018265-twp33bb6	225	7	of	of	IN
cord-018265-twp33bb6	225	8	a	a	DT
cord-018265-twp33bb6	225	9	new	new	JJ
cord-018265-twp33bb6	225	10	generation	generation	NN
cord-018265-twp33bb6	225	11	of	of	IN
cord-018265-twp33bb6	225	12	acellular	acellular	JJ
cord-018265-twp33bb6	225	13	vaccines	vaccine	NNS
cord-018265-twp33bb6	225	14	.	.	.
cord-018265-twp33bb6	226	1	In	in	IN
cord-018265-twp33bb6	226	2	1981	1981	CD
cord-018265-twp33bb6	226	3	Japan	Japan	NNP
cord-018265-twp33bb6	226	4	was	be	VBD
cord-018265-twp33bb6	226	5	the	the	DT
cord-018265-twp33bb6	226	6	first	first	JJ
cord-018265-twp33bb6	226	7	country	country	NN
cord-018265-twp33bb6	226	8	to	to	TO
cord-018265-twp33bb6	226	9	successfully	successfully	RB
cord-018265-twp33bb6	226	10	introduce	introduce	VB
cord-018265-twp33bb6	226	11	acellular	acellular	JJ
cord-018265-twp33bb6	226	12	vaccines	vaccine	NNS
cord-018265-twp33bb6	226	13	against	against	IN
cord-018265-twp33bb6	226	14	whooping	whooping	JJ
cord-018265-twp33bb6	226	15	cough	cough	NN
cord-018265-twp33bb6	226	16	in	in	IN
cord-018265-twp33bb6	226	17	its	-PRON-	PRP$
cord-018265-twp33bb6	226	18	immunisation	immunisation	NN
cord-018265-twp33bb6	226	19	programme	programme	NN
cord-018265-twp33bb6	226	20	[	[	-LRB-
cord-018265-twp33bb6	226	21	75	75	CD
cord-018265-twp33bb6	226	22	]	]	-RRB-
cord-018265-twp33bb6	226	23	,	,	,
cord-018265-twp33bb6	226	24	leading	lead	VBG
cord-018265-twp33bb6	226	25	to	to	IN
cord-018265-twp33bb6	226	26	a	a	DT
cord-018265-twp33bb6	226	27	consistent	consistent	JJ
cord-018265-twp33bb6	226	28	reduction	reduction	NN
cord-018265-twp33bb6	226	29	in	in	IN
cord-018265-twp33bb6	226	30	the	the	DT
cord-018265-twp33bb6	226	31	reported	report	VBN
cord-018265-twp33bb6	226	32	side	side	NN
cord-018265-twp33bb6	226	33	-	-	HYPH
cord-018265-twp33bb6	226	34	effects	effect	NNS
cord-018265-twp33bb6	226	35	.	.	.
cord-018265-twp33bb6	227	1	In	in	IN
cord-018265-twp33bb6	227	2	the	the	DT
cord-018265-twp33bb6	227	3	mid	mid	NNP
cord-018265-twp33bb6	227	4	1980	1980	CD
cord-018265-twp33bb6	227	5	's	's	POS
cord-018265-twp33bb6	227	6	a	a	DT
cord-018265-twp33bb6	227	7	major	major	JJ
cord-018265-twp33bb6	227	8	phase	phase	NN
cord-018265-twp33bb6	227	9	III	iii	CD
cord-018265-twp33bb6	227	10	trial	trial	NN
cord-018265-twp33bb6	227	11	of	of	IN
cord-018265-twp33bb6	227	12	acellular	acellular	JJ
cord-018265-twp33bb6	227	13	vaccines	vaccine	NNS
cord-018265-twp33bb6	227	14	was	be	VBD
cord-018265-twp33bb6	227	15	undertaken	undertake	VBN
cord-018265-twp33bb6	227	16	in	in	IN
cord-018265-twp33bb6	227	17	Sweden	Sweden	NNP
cord-018265-twp33bb6	227	18	,	,	,
cord-018265-twp33bb6	227	19	at	at	IN
cord-018265-twp33bb6	227	20	a	a	DT
cord-018265-twp33bb6	227	21	time	time	NN
cord-018265-twp33bb6	227	22	when	when	WRB
cord-018265-twp33bb6	227	23	the	the	DT
cord-018265-twp33bb6	227	24	banning	banning	NN
cord-018265-twp33bb6	227	25	of	of	IN
cord-018265-twp33bb6	227	26	the	the	DT
cord-018265-twp33bb6	227	27	whole	whole	JJ
cord-018265-twp33bb6	227	28	cell	cell	NN
cord-018265-twp33bb6	227	29	vaccine	vaccine	NN
cord-018265-twp33bb6	227	30	had	have	VBD
cord-018265-twp33bb6	227	31	resulted	result	VBN
cord-018265-twp33bb6	227	32	in	in	IN
cord-018265-twp33bb6	227	33	a	a	DT
cord-018265-twp33bb6	227	34	pertussis	pertussis	NN
cord-018265-twp33bb6	227	35	epidemic	epidemic	NN
cord-018265-twp33bb6	227	36	in	in	IN
cord-018265-twp33bb6	227	37	that	that	DT
cord-018265-twp33bb6	227	38	country	country	NN
cord-018265-twp33bb6	227	39	[	[	-LRB-
cord-018265-twp33bb6	227	40	76	76	CD
cord-018265-twp33bb6	227	41	]	]	-RRB-
cord-018265-twp33bb6	227	42	.	.	.
cord-018265-twp33bb6	228	1	The	the	DT
cord-018265-twp33bb6	228	2	first	first	JJ
cord-018265-twp33bb6	228	3	vaccine	vaccine	NN
cord-018265-twp33bb6	228	4	trials	trial	NNS
cord-018265-twp33bb6	228	5	contained	contain	VBN
cord-018265-twp33bb6	228	6	chemically	chemically	RB
cord-018265-twp33bb6	228	7	detoxified	detoxify	VBN
cord-018265-twp33bb6	228	8	pertussis	pertussis	NN
cord-018265-twp33bb6	228	9	toxin	toxin	NN
cord-018265-twp33bb6	228	10	(	(	-LRB-
cord-018265-twp33bb6	228	11	PT	PT	NNP
cord-018265-twp33bb6	228	12	)	)	-RRB-
cord-018265-twp33bb6	228	13	and	and	CC
cord-018265-twp33bb6	228	14	filamentous	filamentous	JJ
cord-018265-twp33bb6	228	15	haemagglutinin	haemagglutinin	NNP
cord-018265-twp33bb6	228	16	(	(	-LRB-
cord-018265-twp33bb6	228	17	FHA	FHA	NNP
cord-018265-twp33bb6	228	18	)	)	-RRB-
cord-018265-twp33bb6	228	19	,	,	,
cord-018265-twp33bb6	228	20	or	or	CC
cord-018265-twp33bb6	228	21	detoxified	detoxify	VBN
cord-018265-twp33bb6	228	22	PT	PT	NNP
cord-018265-twp33bb6	228	23	alone	alone	RB
cord-018265-twp33bb6	228	24	.	.	.
cord-018265-twp33bb6	229	1	The	the	DT
cord-018265-twp33bb6	229	2	results	result	NNS
cord-018265-twp33bb6	229	3	of	of	IN
cord-018265-twp33bb6	229	4	these	these	DT
cord-018265-twp33bb6	229	5	trials	trial	NNS
cord-018265-twp33bb6	229	6	showed	show	VBD
cord-018265-twp33bb6	229	7	that	that	IN
cord-018265-twp33bb6	229	8	whilst	whilst	IN
cord-018265-twp33bb6	229	9	producing	produce	VBG
cord-018265-twp33bb6	229	10	good	good	JJ
cord-018265-twp33bb6	229	11	antibody	antibody	NN
cord-018265-twp33bb6	229	12	responses	response	NNS
cord-018265-twp33bb6	229	13	,	,	,
cord-018265-twp33bb6	229	14	the	the	DT
cord-018265-twp33bb6	229	15	vaccines	vaccine	NNS
cord-018265-twp33bb6	229	16	failed	fail	VBD
cord-018265-twp33bb6	229	17	to	to	TO
cord-018265-twp33bb6	229	18	give	give	VB
cord-018265-twp33bb6	229	19	an	an	DT
cord-018265-twp33bb6	229	20	adequate	adequate	JJ
cord-018265-twp33bb6	229	21	level	level	NN
cord-018265-twp33bb6	229	22	of	of	IN
cord-018265-twp33bb6	229	23	protection	protection	NN
cord-018265-twp33bb6	229	24	in	in	IN
cord-018265-twp33bb6	229	25	infants	infant	NNS
cord-018265-twp33bb6	229	26	.	.	.
cord-018265-twp33bb6	230	1	The	the	DT
cord-018265-twp33bb6	230	2	mono	mono	NN
cord-018265-twp33bb6	230	3	-	-	HYPH
cord-018265-twp33bb6	230	4	component	component	NN
cord-018265-twp33bb6	230	5	vaccine	vaccine	NN
cord-018265-twp33bb6	230	6	conferred	confer	VBD
cord-018265-twp33bb6	230	7	no	no	DT
cord-018265-twp33bb6	230	8	protection	protection	NN
cord-018265-twp33bb6	230	9	against	against	IN
cord-018265-twp33bb6	230	10	infection	infection	NN
cord-018265-twp33bb6	230	11	,	,	,
cord-018265-twp33bb6	230	12	whereas	whereas	IN
cord-018265-twp33bb6	230	13	the	the	DT
cord-018265-twp33bb6	230	14	use	use	NN
cord-018265-twp33bb6	230	15	of	of	IN
cord-018265-twp33bb6	230	16	the	the	DT
cord-018265-twp33bb6	230	17	two	two	CD
cord-018265-twp33bb6	230	18	component	component	NN
cord-018265-twp33bb6	230	19	candidate	candidate	NN
cord-018265-twp33bb6	230	20	only	only	RB
cord-018265-twp33bb6	230	21	gave	give	VBD
cord-018265-twp33bb6	230	22	incomplete	incomplete	JJ
cord-018265-twp33bb6	230	23	protection	protection	NN
cord-018265-twp33bb6	230	24	against	against	IN
cord-018265-twp33bb6	230	25	infection	infection	NN
cord-018265-twp33bb6	230	26	[	[	-LRB-
cord-018265-twp33bb6	230	27	77	77	CD
cord-018265-twp33bb6	230	28	]	]	-RRB-
cord-018265-twp33bb6	230	29	.	.	.
cord-018265-twp33bb6	231	1	The	the	DT
cord-018265-twp33bb6	231	2	results	result	NNS
cord-018265-twp33bb6	231	3	obtained	obtain	VBN
cord-018265-twp33bb6	231	4	in	in	IN
cord-018265-twp33bb6	231	5	Japan	Japan	NNP
cord-018265-twp33bb6	231	6	and	and	CC
cord-018265-twp33bb6	231	7	Sweden	Sweden	NNP
cord-018265-twp33bb6	231	8	stimulated	stimulate	VBD
cord-018265-twp33bb6	231	9	vaccine	vaccine	NN
cord-018265-twp33bb6	231	10	companies	company	NNS
cord-018265-twp33bb6	231	11	in	in	IN
cord-018265-twp33bb6	231	12	the	the	DT
cord-018265-twp33bb6	231	13	USA	USA	NNP
cord-018265-twp33bb6	231	14	and	and	CC
cord-018265-twp33bb6	231	15	Europe	Europe	NNP
cord-018265-twp33bb6	231	16	to	to	TO
cord-018265-twp33bb6	231	17	establish	establish	VB
cord-018265-twp33bb6	231	18	vigorous	vigorous	JJ
cord-018265-twp33bb6	231	19	research	research	NN
cord-018265-twp33bb6	231	20	programmes	programme	NNS
cord-018265-twp33bb6	231	21	aimed	aim	VBN
cord-018265-twp33bb6	231	22	at	at	IN
cord-018265-twp33bb6	231	23	the	the	DT
cord-018265-twp33bb6	231	24	development	development	NN
cord-018265-twp33bb6	231	25	of	of	IN
cord-018265-twp33bb6	231	26	a	a	DT
cord-018265-twp33bb6	231	27	new	new	JJ
cord-018265-twp33bb6	231	28	generation	generation	NN
cord-018265-twp33bb6	231	29	of	of	IN
cord-018265-twp33bb6	231	30	acellular	acellular	JJ
cord-018265-twp33bb6	231	31	vaccines	vaccine	NNS
cord-018265-twp33bb6	231	32	with	with	IN
cord-018265-twp33bb6	231	33	higher	high	JJR
cord-018265-twp33bb6	231	34	efficacy	efficacy	NN
cord-018265-twp33bb6	231	35	.	.	.
cord-018265-twp33bb6	232	1	Currently	currently	RB
cord-018265-twp33bb6	232	2	available	available	JJ
cord-018265-twp33bb6	232	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	232	4	have	have	VBP
cord-018265-twp33bb6	232	5	incorporated	incorporate	VBN
cord-018265-twp33bb6	232	6	chemically	chemically	RB
cord-018265-twp33bb6	232	7	or	or	CC
cord-018265-twp33bb6	232	8	genetically	genetically	RB
cord-018265-twp33bb6	232	9	inactivated	inactivate	VBN
cord-018265-twp33bb6	232	10	PT	pt	NN
cord-018265-twp33bb6	232	11	and	and	CC
cord-018265-twp33bb6	232	12	additional	additional	JJ
cord-018265-twp33bb6	232	13	virulence	virulence	NN
cord-018265-twp33bb6	232	14	factors	factor	NNS
cord-018265-twp33bb6	232	15	,	,	,
cord-018265-twp33bb6	232	16	such	such	JJ
cord-018265-twp33bb6	232	17	as	as	IN
cord-018265-twp33bb6	232	18	FHA	FHA	NNP
cord-018265-twp33bb6	232	19	,	,	,
cord-018265-twp33bb6	232	20	the	the	DT
cord-018265-twp33bb6	232	21	outer	outer	JJ
cord-018265-twp33bb6	232	22	membrane	membrane	NN
cord-018265-twp33bb6	232	23	protein	protein	NN
cord-018265-twp33bb6	232	24	pertactin	pertactin	NNP
cord-018265-twp33bb6	232	25	(	(	-LRB-
cord-018265-twp33bb6	232	26	PRN	PRN	NNP
cord-018265-twp33bb6	232	27	)	)	-RRB-
cord-018265-twp33bb6	232	28	and	and	CC
cord-018265-twp33bb6	232	29	fimbrial	fimbrial	JJ
cord-018265-twp33bb6	232	30	proteins	protein	NNS
cord-018265-twp33bb6	233	1	(	(	-LRB-
cord-018265-twp33bb6	233	2	FIMs	FIMs	NNP
cord-018265-twp33bb6	233	3	)	)	-RRB-
cord-018265-twp33bb6	233	4	.	.	.
cord-018265-twp33bb6	234	1	The	the	DT
cord-018265-twp33bb6	234	2	efficacy	efficacy	NN
cord-018265-twp33bb6	234	3	studies	study	NNS
cord-018265-twp33bb6	234	4	of	of	IN
cord-018265-twp33bb6	234	5	this	this	DT
cord-018265-twp33bb6	234	6	second	second	JJ
cord-018265-twp33bb6	234	7	generation	generation	NN
cord-018265-twp33bb6	234	8	of	of	IN
cord-018265-twp33bb6	234	9	acellular	acellular	JJ
cord-018265-twp33bb6	234	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	234	11	have	have	VBP
cord-018265-twp33bb6	234	12	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	234	13	that	that	IN
cord-018265-twp33bb6	234	14	they	-PRON-	PRP
cord-018265-twp33bb6	234	15	confer	confer	VBP
cord-018265-twp33bb6	234	16	levels	level	NNS
cord-018265-twp33bb6	234	17	of	of	IN
cord-018265-twp33bb6	234	18	protection	protection	NN
cord-018265-twp33bb6	234	19	equivalent	equivalent	JJ
cord-018265-twp33bb6	234	20	to	to	IN
cord-018265-twp33bb6	234	21	the	the	DT
cord-018265-twp33bb6	234	22	whole	whole	JJ
cord-018265-twp33bb6	234	23	cell	cell	NN
cord-018265-twp33bb6	234	24	vaccines	vaccine	NNS
cord-018265-twp33bb6	234	25	.	.	.
cord-018265-twp33bb6	235	1	The	the	DT
cord-018265-twp33bb6	235	2	advent	advent	NN
cord-018265-twp33bb6	235	3	of	of	IN
cord-018265-twp33bb6	235	4	improved	improved	JJ
cord-018265-twp33bb6	235	5	techniques	technique	NNS
cord-018265-twp33bb6	235	6	for	for	IN
cord-018265-twp33bb6	235	7	antigenic	antigenic	JJ
cord-018265-twp33bb6	235	8	characterisation	characterisation	NN
cord-018265-twp33bb6	235	9	and	and	CC
cord-018265-twp33bb6	235	10	the	the	DT
cord-018265-twp33bb6	235	11	introduction	introduction	NN
cord-018265-twp33bb6	235	12	of	of	IN
cord-018265-twp33bb6	235	13	acellular	acellular	JJ
cord-018265-twp33bb6	235	14	vaccines	vaccine	NNS
cord-018265-twp33bb6	235	15	containing	contain	VBG
cord-018265-twp33bb6	235	16	genetically	genetically	RB
cord-018265-twp33bb6	235	17	defined	define	VBN
cord-018265-twp33bb6	235	18	components	component	NNS
cord-018265-twp33bb6	235	19	also	also	RB
cord-018265-twp33bb6	235	20	resulted	result	VBD
cord-018265-twp33bb6	235	21	in	in	IN
cord-018265-twp33bb6	235	22	a	a	DT
cord-018265-twp33bb6	235	23	reduction	reduction	NN
cord-018265-twp33bb6	235	24	of	of	IN
cord-018265-twp33bb6	235	25	lot	lot	NN
cord-018265-twp33bb6	235	26	-	-	HYPH
cord-018265-twp33bb6	235	27	to	to	IN
cord-018265-twp33bb6	235	28	-	-	HYPH
cord-018265-twp33bb6	235	29	lot	lot	NN
cord-018265-twp33bb6	235	30	variation	variation	NN
cord-018265-twp33bb6	235	31	in	in	IN
cord-018265-twp33bb6	235	32	comparison	comparison	NN
cord-018265-twp33bb6	235	33	with	with	IN
cord-018265-twp33bb6	235	34	conventional	conventional	JJ
cord-018265-twp33bb6	235	35	whole	whole	JJ
cord-018265-twp33bb6	235	36	cell	cell	NN
cord-018265-twp33bb6	235	37	vaccines	vaccine	NNS
cord-018265-twp33bb6	235	38	and	and	CC
cord-018265-twp33bb6	235	39	the	the	DT
cord-018265-twp33bb6	235	40	acellular	acellular	JJ
cord-018265-twp33bb6	235	41	formulation	formulation	NN
cord-018265-twp33bb6	235	42	originally	originally	RB
cord-018265-twp33bb6	235	43	introduced	introduce	VBN
cord-018265-twp33bb6	235	44	in	in	IN
cord-018265-twp33bb6	235	45	Japan	Japan	NNP
cord-018265-twp33bb6	235	46	.	.	.
cord-018265-twp33bb6	236	1	However	however	RB
cord-018265-twp33bb6	236	2	,	,	,
cord-018265-twp33bb6	236	3	despite	despite	IN
cord-018265-twp33bb6	236	4	the	the	DT
cord-018265-twp33bb6	236	5	wide	wide	JJ
cord-018265-twp33bb6	236	6	implementation	implementation	NN
cord-018265-twp33bb6	236	7	of	of	IN
cord-018265-twp33bb6	236	8	vaccination	vaccination	NN
cord-018265-twp33bb6	236	9	campaigns	campaign	NNS
cord-018265-twp33bb6	236	10	in	in	IN
cord-018265-twp33bb6	236	11	infants	infant	NNS
cord-018265-twp33bb6	236	12	and	and	CC
cord-018265-twp33bb6	236	13	children	child	NNS
cord-018265-twp33bb6	236	14	,	,	,
cord-018265-twp33bb6	236	15	the	the	DT
cord-018265-twp33bb6	236	16	disease	disease	NN
cord-018265-twp33bb6	236	17	continues	continue	VBZ
cord-018265-twp33bb6	236	18	to	to	TO
cord-018265-twp33bb6	236	19	be	be	VB
cord-018265-twp33bb6	236	20	endemic	endemic	JJ
cord-018265-twp33bb6	236	21	.	.	.
cord-018265-twp33bb6	237	1	In	in	IN
cord-018265-twp33bb6	237	2	addition	addition	NN
cord-018265-twp33bb6	237	3	,	,	,
cord-018265-twp33bb6	237	4	in	in	IN
cord-018265-twp33bb6	237	5	countries	country	NNS
cord-018265-twp33bb6	237	6	with	with	IN
cord-018265-twp33bb6	237	7	high	high	JJ
cord-018265-twp33bb6	237	8	vaccine	vaccine	NN
cord-018265-twp33bb6	237	9	coverage	coverage	NN
cord-018265-twp33bb6	237	10	we	-PRON-	PRP
cord-018265-twp33bb6	237	11	are	be	VBP
cord-018265-twp33bb6	237	12	now	now	RB
cord-018265-twp33bb6	237	13	observing	observe	VBG
cord-018265-twp33bb6	237	14	a	a	DT
cord-018265-twp33bb6	237	15	consistent	consistent	JJ
cord-018265-twp33bb6	237	16	increment	increment	NN
cord-018265-twp33bb6	237	17	in	in	IN
cord-018265-twp33bb6	237	18	the	the	DT
cord-018265-twp33bb6	237	19	cases	case	NNS
cord-018265-twp33bb6	237	20	of	of	IN
cord-018265-twp33bb6	237	21	pertussis	pertussis	NN
cord-018265-twp33bb6	237	22	in	in	IN
cord-018265-twp33bb6	237	23	adolescents	adolescent	NNS
cord-018265-twp33bb6	237	24	and	and	CC
cord-018265-twp33bb6	237	25	adults	adult	NNS
cord-018265-twp33bb6	237	26	[	[	-LRB-
cord-018265-twp33bb6	237	27	78	78	CD
cord-018265-twp33bb6	237	28	]	]	-RRB-
cord-018265-twp33bb6	237	29	[	[	-LRB-
cord-018265-twp33bb6	237	30	79	79	CD
cord-018265-twp33bb6	237	31	]	]	-RRB-
cord-018265-twp33bb6	237	32	[	[	-LRB-
cord-018265-twp33bb6	237	33	80	80	CD
cord-018265-twp33bb6	237	34	]	]	-RRB-
cord-018265-twp33bb6	237	35	.	.	.
cord-018265-twp33bb6	238	1	These	these	DT
cord-018265-twp33bb6	238	2	patients	patient	NNS
cord-018265-twp33bb6	238	3	can	can	MD
cord-018265-twp33bb6	238	4	then	then	RB
cord-018265-twp33bb6	238	5	transmit	transmit	VB
cord-018265-twp33bb6	238	6	the	the	DT
cord-018265-twp33bb6	238	7	disease	disease	NN
cord-018265-twp33bb6	238	8	to	to	IN
cord-018265-twp33bb6	238	9	infants	infant	NNS
cord-018265-twp33bb6	238	10	,	,	,
cord-018265-twp33bb6	238	11	thereby	thereby	RB
cord-018265-twp33bb6	238	12	now	now	RB
cord-018265-twp33bb6	238	13	representing	represent	VBG
cord-018265-twp33bb6	238	14	a	a	DT
cord-018265-twp33bb6	238	15	primary	primary	JJ
cord-018265-twp33bb6	238	16	reservoir	reservoir	NN
cord-018265-twp33bb6	238	17	for	for	IN
cord-018265-twp33bb6	238	18	bacterial	bacterial	JJ
cord-018265-twp33bb6	238	19	transmission	transmission	NN
cord-018265-twp33bb6	238	20	and	and	CC
cord-018265-twp33bb6	238	21	cycling	cycling	NN
cord-018265-twp33bb6	238	22	in	in	IN
cord-018265-twp33bb6	238	23	the	the	DT
cord-018265-twp33bb6	238	24	community	community	NN
cord-018265-twp33bb6	238	25	.	.	.
cord-018265-twp33bb6	239	1	The	the	DT
cord-018265-twp33bb6	239	2	above	above	RB
cord-018265-twp33bb6	239	3	-	-	HYPH
cord-018265-twp33bb6	239	4	mentioned	mention	VBN
cord-018265-twp33bb6	239	5	observations	observation	NNS
cord-018265-twp33bb6	239	6	can	can	MD
cord-018265-twp33bb6	239	7	be	be	VB
cord-018265-twp33bb6	239	8	explained	explain	VBN
cord-018265-twp33bb6	239	9	by	by	IN
cord-018265-twp33bb6	239	10	one	one	CD
cord-018265-twp33bb6	239	11	or	or	CC
cord-018265-twp33bb6	239	12	more	more	JJR
cord-018265-twp33bb6	239	13	of	of	IN
cord-018265-twp33bb6	239	14	the	the	DT
cord-018265-twp33bb6	239	15	following	following	JJ
cord-018265-twp33bb6	239	16	factors	factor	NNS
cord-018265-twp33bb6	239	17	:	:	:
cord-018265-twp33bb6	239	18	(	(	-LRB-
cord-018265-twp33bb6	239	19	i	i	NN
cord-018265-twp33bb6	239	20	)	)	-RRB-
cord-018265-twp33bb6	239	21	improved	improve	VBN
cord-018265-twp33bb6	239	22	detection	detection	NN
cord-018265-twp33bb6	239	23	techniques	technique	NNS
cord-018265-twp33bb6	239	24	,	,	,
cord-018265-twp33bb6	239	25	(	(	-LRB-
cord-018265-twp33bb6	239	26	ii	ii	NN
cord-018265-twp33bb6	239	27	)	)	-RRB-
cord-018265-twp33bb6	239	28	major	major	JJ
cord-018265-twp33bb6	239	29	awareness	awareness	NN
cord-018265-twp33bb6	239	30	on	on	IN
cord-018265-twp33bb6	239	31	the	the	DT
cord-018265-twp33bb6	239	32	possibility	possibility	NN
cord-018265-twp33bb6	239	33	that	that	IN
cord-018265-twp33bb6	239	34	bacteria	bacteria	NNS
cord-018265-twp33bb6	239	35	may	may	MD
cord-018265-twp33bb6	239	36	affect	affect	VB
cord-018265-twp33bb6	239	37	these	these	DT
cord-018265-twp33bb6	239	38	age	age	NN
cord-018265-twp33bb6	239	39	groups	group	NNS
cord-018265-twp33bb6	239	40	,	,	,
cord-018265-twp33bb6	239	41	(	(	-LRB-
cord-018265-twp33bb6	239	42	iii	iii	NNP
cord-018265-twp33bb6	239	43	)	)	-RRB-
cord-018265-twp33bb6	239	44	vaccinedriven	vaccinedriven	NNP
cord-018265-twp33bb6	239	45	antigenic	antigenic	JJ
cord-018265-twp33bb6	239	46	changes	change	NNS
cord-018265-twp33bb6	239	47	in	in	IN
cord-018265-twp33bb6	239	48	circulating	circulate	VBG
cord-018265-twp33bb6	239	49	isolates	isolate	NNS
cord-018265-twp33bb6	239	50	,	,	,
cord-018265-twp33bb6	239	51	and	and	CC
cord-018265-twp33bb6	239	52	(	(	-LRB-
cord-018265-twp33bb6	239	53	iv	iv	LS
cord-018265-twp33bb6	239	54	)	)	-RRB-
cord-018265-twp33bb6	239	55	reduction	reduction	NN
cord-018265-twp33bb6	239	56	in	in	IN
cord-018265-twp33bb6	239	57	vaccine	vaccine	NN
cord-018265-twp33bb6	239	58	efficacy	efficacy	NN
cord-018265-twp33bb6	239	59	over	over	IN
cord-018265-twp33bb6	239	60	time	time	NN
cord-018265-twp33bb6	239	61	.	.	.
cord-018265-twp33bb6	240	1	In	in	IN
cord-018265-twp33bb6	240	2	this	this	DT
cord-018265-twp33bb6	240	3	context	context	NN
cord-018265-twp33bb6	240	4	,	,	,
cord-018265-twp33bb6	240	5	concerns	concern	NNS
cord-018265-twp33bb6	240	6	have	have	VBP
cord-018265-twp33bb6	240	7	been	be	VBN
cord-018265-twp33bb6	240	8	raised	raise	VBN
cord-018265-twp33bb6	240	9	about	about	IN
cord-018265-twp33bb6	240	10	genetic	genetic	JJ
cord-018265-twp33bb6	240	11	variation	variation	NN
cord-018265-twp33bb6	240	12	between	between	IN
cord-018265-twp33bb6	240	13	the	the	DT
cord-018265-twp33bb6	240	14	strains	strain	NNS
cord-018265-twp33bb6	240	15	used	use	VBN
cord-018265-twp33bb6	240	16	for	for	IN
cord-018265-twp33bb6	240	17	vaccine	vaccine	NN
cord-018265-twp33bb6	240	18	preparation	preparation	NN
cord-018265-twp33bb6	240	19	and	and	CC
cord-018265-twp33bb6	240	20	circulating	circulate	VBG
cord-018265-twp33bb6	240	21	isolates	isolate	NNS
cord-018265-twp33bb6	240	22	.	.	.
cord-018265-twp33bb6	241	1	This	this	DT
cord-018265-twp33bb6	241	2	seems	seem	VBZ
cord-018265-twp33bb6	241	3	to	to	TO
cord-018265-twp33bb6	241	4	be	be	VB
cord-018265-twp33bb6	241	5	true	true	JJ
cord-018265-twp33bb6	241	6	,	,	,
cord-018265-twp33bb6	241	7	since	since	IN
cord-018265-twp33bb6	241	8	the	the	DT
cord-018265-twp33bb6	241	9	currently	currently	RB
cord-018265-twp33bb6	241	10	used	use	VBN
cord-018265-twp33bb6	241	11	whole	whole	JJ
cord-018265-twp33bb6	241	12	cell	cell	NN
cord-018265-twp33bb6	241	13	and	and	CC
cord-018265-twp33bb6	241	14	acellular	acellular	JJ
cord-018265-twp33bb6	241	15	vaccines	vaccine	NNS
cord-018265-twp33bb6	241	16	are	be	VBP
cord-018265-twp33bb6	241	17	prepared	prepare	VBN
cord-018265-twp33bb6	241	18	with	with	IN
cord-018265-twp33bb6	241	19	strains	strain	NNS
cord-018265-twp33bb6	241	20	that	that	WDT
cord-018265-twp33bb6	241	21	were	be	VBD
cord-018265-twp33bb6	241	22	isolated	isolate	VBN
cord-018265-twp33bb6	241	23	before	before	IN
cord-018265-twp33bb6	241	24	mass	mass	JJ
cord-018265-twp33bb6	241	25	vaccine	vaccine	NN
cord-018265-twp33bb6	241	26	introduction	introduction	NN
cord-018265-twp33bb6	241	27	and	and	CC
cord-018265-twp33bb6	241	28	show	show	VB
cord-018265-twp33bb6	241	29	clear	clear	JJ
cord-018265-twp33bb6	241	30	mismatches	mismatch	NNS
cord-018265-twp33bb6	241	31	with	with	IN
cord-018265-twp33bb6	241	32	respect	respect	NN
cord-018265-twp33bb6	241	33	to	to	IN
cord-018265-twp33bb6	241	34	circulating	circulate	VBG
cord-018265-twp33bb6	241	35	strains	strain	NNS
cord-018265-twp33bb6	241	36	.	.	.
cord-018265-twp33bb6	242	1	There	there	EX
cord-018265-twp33bb6	242	2	is	be	VBZ
cord-018265-twp33bb6	242	3	a	a	DT
cord-018265-twp33bb6	242	4	steady	steady	JJ
cord-018265-twp33bb6	242	5	tendency	tendency	NN
cord-018265-twp33bb6	242	6	to	to	TO
cord-018265-twp33bb6	242	7	decrease	decrease	VB
cord-018265-twp33bb6	242	8	diversity	diversity	NN
cord-018265-twp33bb6	242	9	in	in	IN
cord-018265-twp33bb6	242	10	recent	recent	JJ
cord-018265-twp33bb6	242	11	isolates	isolate	NNS
cord-018265-twp33bb6	242	12	,	,	,
cord-018265-twp33bb6	242	13	together	together	RB
cord-018265-twp33bb6	242	14	with	with	IN
cord-018265-twp33bb6	242	15	clonal	clonal	JJ
cord-018265-twp33bb6	242	16	expansion	expansion	NN
cord-018265-twp33bb6	242	17	during	during	IN
cord-018265-twp33bb6	242	18	epidemic	epidemic	NN
cord-018265-twp33bb6	242	19	outbreaks	outbreak	NNS
cord-018265-twp33bb6	242	20	[	[	-LRB-
cord-018265-twp33bb6	242	21	81	81	CD
cord-018265-twp33bb6	242	22	,	,	,
cord-018265-twp33bb6	242	23	82	82	CD
cord-018265-twp33bb6	242	24	]	]	-RRB-
cord-018265-twp33bb6	242	25	.	.	.
cord-018265-twp33bb6	243	1	Over	over	IN
cord-018265-twp33bb6	243	2	time	time	NN
cord-018265-twp33bb6	243	3	,	,	,
cord-018265-twp33bb6	243	4	at	at	RB
cord-018265-twp33bb6	243	5	least	least	RBS
cord-018265-twp33bb6	243	6	two	two	CD
cord-018265-twp33bb6	243	7	surface	surface	NN
cord-018265-twp33bb6	243	8	proteins	protein	NNS
cord-018265-twp33bb6	243	9	(	(	-LRB-
cord-018265-twp33bb6	243	10	PT	PT	NNP
cord-018265-twp33bb6	243	11	and	and	CC
cord-018265-twp33bb6	243	12	PRN	PRN	NNP
cord-018265-twp33bb6	243	13	)	)	-RRB-
cord-018265-twp33bb6	243	14	may	may	MD
cord-018265-twp33bb6	243	15	have	have	VB
cord-018265-twp33bb6	243	16	changed	change	VBN
cord-018265-twp33bb6	243	17	sufficiently	sufficiently	RB
cord-018265-twp33bb6	243	18	to	to	TO
cord-018265-twp33bb6	243	19	allow	allow	VB
cord-018265-twp33bb6	243	20	for	for	IN
cord-018265-twp33bb6	243	21	an	an	DT
cord-018265-twp33bb6	243	22	increase	increase	NN
cord-018265-twp33bb6	243	23	in	in	IN
cord-018265-twp33bb6	243	24	the	the	DT
cord-018265-twp33bb6	243	25	incidence	incidence	NN
cord-018265-twp33bb6	243	26	of	of	IN
cord-018265-twp33bb6	243	27	disease	disease	NN
cord-018265-twp33bb6	243	28	.	.	.
cord-018265-twp33bb6	244	1	Unfortunately	unfortunately	RB
cord-018265-twp33bb6	244	2	,	,	,
cord-018265-twp33bb6	244	3	our	-PRON-	PRP$
cord-018265-twp33bb6	244	4	global	global	JJ
cord-018265-twp33bb6	244	5	information	information	NN
cord-018265-twp33bb6	244	6	on	on	IN
cord-018265-twp33bb6	244	7	antigenic	antigenic	JJ
cord-018265-twp33bb6	244	8	variation	variation	NN
cord-018265-twp33bb6	244	9	and	and	CC
cord-018265-twp33bb6	244	10	disease	disease	NN
cord-018265-twp33bb6	244	11	in	in	IN
cord-018265-twp33bb6	244	12	adults	adult	NNS
cord-018265-twp33bb6	244	13	and	and	CC
cord-018265-twp33bb6	244	14	adolescent	adolescent	JJ
cord-018265-twp33bb6	244	15	is	be	VBZ
cord-018265-twp33bb6	244	16	extremely	extremely	RB
cord-018265-twp33bb6	244	17	limited	limited	JJ
cord-018265-twp33bb6	244	18	.	.	.
cord-018265-twp33bb6	245	1	Thus	thus	RB
cord-018265-twp33bb6	245	2	,	,	,
cord-018265-twp33bb6	245	3	despite	despite	IN
cord-018265-twp33bb6	245	4	widespread	widespread	JJ
cord-018265-twp33bb6	245	5	introduction	introduction	NN
cord-018265-twp33bb6	245	6	of	of	IN
cord-018265-twp33bb6	245	7	pertussis	pertussis	NN
cord-018265-twp33bb6	245	8	vaccines	vaccine	NNS
cord-018265-twp33bb6	245	9	,	,	,
cord-018265-twp33bb6	245	10	it	-PRON-	PRP
cord-018265-twp33bb6	245	11	is	be	VBZ
cord-018265-twp33bb6	245	12	essential	essential	JJ
cord-018265-twp33bb6	245	13	to	to	TO
cord-018265-twp33bb6	245	14	continue	continue	VB
cord-018265-twp33bb6	245	15	surveillance	surveillance	NN
cord-018265-twp33bb6	245	16	studies	study	NNS
cord-018265-twp33bb6	245	17	and	and	CC
cord-018265-twp33bb6	245	18	collection	collection	NN
cord-018265-twp33bb6	245	19	of	of	IN
cord-018265-twp33bb6	245	20	circulating	circulate	VBG
cord-018265-twp33bb6	245	21	strains	strain	NNS
cord-018265-twp33bb6	245	22	.	.	.
cord-018265-twp33bb6	246	1	The	the	DT
cord-018265-twp33bb6	246	2	present	present	JJ
cord-018265-twp33bb6	246	3	view	view	NN
cord-018265-twp33bb6	246	4	is	be	VBZ
cord-018265-twp33bb6	246	5	that	that	DT
cord-018265-twp33bb6	246	6	successful	successful	JJ
cord-018265-twp33bb6	246	7	control	control	NN
cord-018265-twp33bb6	246	8	of	of	IN
cord-018265-twp33bb6	246	9	pertussis	pertussis	NN
cord-018265-twp33bb6	246	10	in	in	IN
cord-018265-twp33bb6	246	11	the	the	DT
cord-018265-twp33bb6	246	12	community	community	NN
cord-018265-twp33bb6	246	13	may	may	MD
cord-018265-twp33bb6	246	14	require	require	VB
cord-018265-twp33bb6	246	15	routine	routine	JJ
cord-018265-twp33bb6	246	16	immunization	immunization	NN
cord-018265-twp33bb6	246	17	of	of	IN
cord-018265-twp33bb6	246	18	adolescents	adolescent	NNS
cord-018265-twp33bb6	246	19	and	and	CC
cord-018265-twp33bb6	246	20	adults	adult	NNS
cord-018265-twp33bb6	246	21	with	with	IN
cord-018265-twp33bb6	246	22	the	the	DT
cord-018265-twp33bb6	246	23	new	new	JJ
cord-018265-twp33bb6	246	24	acellular	acellular	JJ
cord-018265-twp33bb6	246	25	vaccines	vaccine	NNS
cord-018265-twp33bb6	246	26	,	,	,
cord-018265-twp33bb6	246	27	perhaps	perhaps	RB
cord-018265-twp33bb6	246	28	in	in	IN
cord-018265-twp33bb6	246	29	combination	combination	NN
cord-018265-twp33bb6	246	30	with	with	IN
cord-018265-twp33bb6	246	31	the	the	DT
cord-018265-twp33bb6	246	32	diphtheria	diphtheria	NN
cord-018265-twp33bb6	246	33	and	and	CC
cord-018265-twp33bb6	246	34	tetanus	tetanus	NN
cord-018265-twp33bb6	246	35	toxoids	toxoid	NNS
cord-018265-twp33bb6	246	36	(	(	-LRB-
cord-018265-twp33bb6	246	37	DTaP	DTaP	NNP
cord-018265-twp33bb6	246	38	)	)	-RRB-
cord-018265-twp33bb6	246	39	.	.	.
cord-018265-twp33bb6	247	1	This	this	DT
cord-018265-twp33bb6	247	2	intervention	intervention	NN
cord-018265-twp33bb6	247	3	might	may	MD
cord-018265-twp33bb6	247	4	help	help	VB
cord-018265-twp33bb6	247	5	in	in	IN
cord-018265-twp33bb6	247	6	turn	turn	NN
cord-018265-twp33bb6	247	7	to	to	TO
cord-018265-twp33bb6	247	8	reduce	reduce	VB
cord-018265-twp33bb6	247	9	the	the	DT
cord-018265-twp33bb6	247	10	burden	burden	NN
cord-018265-twp33bb6	247	11	of	of	IN
cord-018265-twp33bb6	247	12	disease	disease	NN
cord-018265-twp33bb6	247	13	and	and	CC
cord-018265-twp33bb6	247	14	transmission	transmission	NN
cord-018265-twp33bb6	247	15	to	to	IN
cord-018265-twp33bb6	247	16	infants	infant	NNS
cord-018265-twp33bb6	247	17	.	.	.
cord-018265-twp33bb6	248	1	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	248	2	pneumonia	pneumonia	NN
cord-018265-twp33bb6	248	3	is	be	VBZ
cord-018265-twp33bb6	248	4	an	an	DT
cord-018265-twp33bb6	248	5	intracellular	intracellular	JJ
cord-018265-twp33bb6	248	6	bacterium	bacterium	NN
cord-018265-twp33bb6	248	7	transmitted	transmit	VBN
cord-018265-twp33bb6	248	8	person	person	NN
cord-018265-twp33bb6	248	9	-	-	HYPH
cord-018265-twp33bb6	248	10	toperson	toperson	NN
cord-018265-twp33bb6	248	11	via	via	IN
cord-018265-twp33bb6	248	12	respiratory	respiratory	JJ
cord-018265-twp33bb6	248	13	droplets	droplet	NNS
cord-018265-twp33bb6	248	14	.	.	.
cord-018265-twp33bb6	249	1	This	this	DT
cord-018265-twp33bb6	249	2	pathogen	pathogen	NN
cord-018265-twp33bb6	249	3	is	be	VBZ
cord-018265-twp33bb6	249	4	a	a	DT
cord-018265-twp33bb6	249	5	common	common	JJ
cord-018265-twp33bb6	249	6	cause	cause	NN
cord-018265-twp33bb6	249	7	of	of	IN
cord-018265-twp33bb6	249	8	pneumonia	pneumonia	NN
cord-018265-twp33bb6	249	9	,	,	,
cord-018265-twp33bb6	249	10	with	with	IN
cord-018265-twp33bb6	249	11	infections	infection	NNS
cord-018265-twp33bb6	249	12	usually	usually	RB
cord-018265-twp33bb6	249	13	being	be	VBG
cord-018265-twp33bb6	249	14	oligosymptomatic	oligosymptomatic	JJ
cord-018265-twp33bb6	249	15	or	or	CC
cord-018265-twp33bb6	249	16	asymptomatic	asymptomatic	JJ
cord-018265-twp33bb6	249	17	in	in	IN
cord-018265-twp33bb6	249	18	young	young	JJ
cord-018265-twp33bb6	249	19	age	age	NN
cord-018265-twp33bb6	249	20	groups	group	NNS
cord-018265-twp33bb6	249	21	.	.	.
cord-018265-twp33bb6	250	1	However	however	RB
cord-018265-twp33bb6	250	2	,	,	,
cord-018265-twp33bb6	250	3	the	the	DT
cord-018265-twp33bb6	250	4	rate	rate	NN
cord-018265-twp33bb6	250	5	of	of	IN
cord-018265-twp33bb6	250	6	asymptomatic	asymptomatic	JJ
cord-018265-twp33bb6	250	7	carriage	carriage	NN
cord-018265-twp33bb6	250	8	in	in	IN
cord-018265-twp33bb6	250	9	the	the	DT
cord-018265-twp33bb6	250	10	normal	normal	JJ
cord-018265-twp33bb6	250	11	population	population	NN
cord-018265-twp33bb6	250	12	is	be	VBZ
cord-018265-twp33bb6	250	13	unknown	unknown	JJ
cord-018265-twp33bb6	250	14	.	.	.
cord-018265-twp33bb6	251	1	There	there	EX
cord-018265-twp33bb6	251	2	is	be	VBZ
cord-018265-twp33bb6	251	3	also	also	RB
cord-018265-twp33bb6	251	4	a	a	DT
cord-018265-twp33bb6	251	5	tremendous	tremendous	JJ
cord-018265-twp33bb6	251	6	gap	gap	NN
cord-018265-twp33bb6	251	7	in	in	IN
cord-018265-twp33bb6	251	8	our	-PRON-	PRP$
cord-018265-twp33bb6	251	9	understanding	understanding	NN
cord-018265-twp33bb6	251	10	of	of	IN
cord-018265-twp33bb6	251	11	host	host	NN
cord-018265-twp33bb6	251	12	response	response	NN
cord-018265-twp33bb6	251	13	to	to	IN
cord-018265-twp33bb6	251	14	infections	infection	NNS
cord-018265-twp33bb6	251	15	caused	cause	VBN
cord-018265-twp33bb6	251	16	by	by	IN
cord-018265-twp33bb6	251	17	C.	C.	NNP
cord-018265-twp33bb6	251	18	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	251	19	.	.	.
cord-018265-twp33bb6	252	1	Most	Most	JJS
cord-018265-twp33bb6	252	2	of	of	IN
cord-018265-twp33bb6	252	3	the	the	DT
cord-018265-twp33bb6	252	4	studies	study	NNS
cord-018265-twp33bb6	252	5	have	have	VBP
cord-018265-twp33bb6	252	6	been	be	VBN
cord-018265-twp33bb6	252	7	focused	focus	VBN
cord-018265-twp33bb6	252	8	on	on	IN
cord-018265-twp33bb6	252	9	the	the	DT
cord-018265-twp33bb6	252	10	development	development	NN
cord-018265-twp33bb6	252	11	of	of	IN
cord-018265-twp33bb6	252	12	efficient	efficient	JJ
cord-018265-twp33bb6	252	13	diagnostic	diagnostic	JJ
cord-018265-twp33bb6	252	14	methods	method	NNS
cord-018265-twp33bb6	252	15	.	.	.
cord-018265-twp33bb6	253	1	However	however	RB
cord-018265-twp33bb6	253	2	,	,	,
cord-018265-twp33bb6	253	3	less	less	JJR
cord-018265-twp33bb6	253	4	work	work	NN
cord-018265-twp33bb6	253	5	has	have	VBZ
cord-018265-twp33bb6	253	6	been	be	VBN
cord-018265-twp33bb6	253	7	done	do	VBN
cord-018265-twp33bb6	253	8	on	on	IN
cord-018265-twp33bb6	253	9	vaccine	vaccine	NN
cord-018265-twp33bb6	253	10	development	development	NN
cord-018265-twp33bb6	253	11	,	,	,
cord-018265-twp33bb6	253	12	and	and	CC
cord-018265-twp33bb6	253	13	there	there	EX
cord-018265-twp33bb6	253	14	is	be	VBZ
cord-018265-twp33bb6	253	15	a	a	DT
cord-018265-twp33bb6	253	16	paucity	paucity	NN
cord-018265-twp33bb6	253	17	of	of	IN
cord-018265-twp33bb6	253	18	knowledge	knowledge	NN
cord-018265-twp33bb6	253	19	on	on	IN
cord-018265-twp33bb6	253	20	the	the	DT
cord-018265-twp33bb6	253	21	microbial	microbial	JJ
cord-018265-twp33bb6	253	22	components	component	NNS
cord-018265-twp33bb6	253	23	which	which	WDT
cord-018265-twp33bb6	253	24	may	may	MD
cord-018265-twp33bb6	253	25	serve	serve	VB
cord-018265-twp33bb6	253	26	as	as	IN
cord-018265-twp33bb6	253	27	target	target	NN
cord-018265-twp33bb6	253	28	antigens	antigen	NNS
cord-018265-twp33bb6	253	29	.	.	.
cord-018265-twp33bb6	254	1	In	in	IN
cord-018265-twp33bb6	254	2	fact	fact	NN
cord-018265-twp33bb6	254	3	,	,	,
cord-018265-twp33bb6	254	4	at	at	IN
cord-018265-twp33bb6	254	5	present	present	NN
cord-018265-twp33bb6	254	6	there	there	EX
cord-018265-twp33bb6	254	7	are	be	VBP
cord-018265-twp33bb6	254	8	no	no	DT
cord-018265-twp33bb6	254	9	licensed	licensed	JJ
cord-018265-twp33bb6	254	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	254	11	against	against	IN
cord-018265-twp33bb6	254	12	C.	C.	NNP
cord-018265-twp33bb6	254	13	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	254	14	.	.	.
cord-018265-twp33bb6	255	1	However	however	RB
cord-018265-twp33bb6	255	2	,	,	,
cord-018265-twp33bb6	255	3	the	the	DT
cord-018265-twp33bb6	255	4	potential	potential	NN
cord-018265-twp33bb6	255	5	of	of	IN
cord-018265-twp33bb6	255	6	different	different	JJ
cord-018265-twp33bb6	255	7	antigens	antigen	NNS
cord-018265-twp33bb6	255	8	,	,	,
cord-018265-twp33bb6	255	9	such	such	JJ
cord-018265-twp33bb6	255	10	as	as	IN
cord-018265-twp33bb6	255	11	the	the	DT
cord-018265-twp33bb6	255	12	major	major	JJ
cord-018265-twp33bb6	255	13	OMP2	OMP2	NNP
cord-018265-twp33bb6	255	14	[	[	-LRB-
cord-018265-twp33bb6	255	15	83	83	CD
cord-018265-twp33bb6	255	16	]	]	-RRB-
cord-018265-twp33bb6	255	17	have	have	VBP
cord-018265-twp33bb6	255	18	been	be	VBN
cord-018265-twp33bb6	255	19	assessed	assess	VBN
cord-018265-twp33bb6	255	20	in	in	IN
cord-018265-twp33bb6	255	21	experimental	experimental	JJ
cord-018265-twp33bb6	255	22	animal	animal	NN
cord-018265-twp33bb6	255	23	models	model	NNS
cord-018265-twp33bb6	255	24	.	.	.
cord-018265-twp33bb6	256	1	Nevertheless	nevertheless	RB
cord-018265-twp33bb6	256	2	,	,	,
cord-018265-twp33bb6	256	3	mice	mouse	NNS
cord-018265-twp33bb6	256	4	vaccinated	vaccinate	VBN
cord-018265-twp33bb6	256	5	with	with	IN
cord-018265-twp33bb6	256	6	OMP2	OMP2	NNP
cord-018265-twp33bb6	256	7	using	use	VBG
cord-018265-twp33bb6	256	8	a	a	DT
cord-018265-twp33bb6	256	9	protocol	protocol	NN
cord-018265-twp33bb6	256	10	based	base	VBN
cord-018265-twp33bb6	256	11	on	on	IN
cord-018265-twp33bb6	256	12	priming	prime	VBG
cord-018265-twp33bb6	256	13	with	with	IN
cord-018265-twp33bb6	256	14	DNA	dna	NN
cord-018265-twp33bb6	256	15	and	and	CC
cord-018265-twp33bb6	256	16	boosting	boost	VBG
cord-018265-twp33bb6	256	17	with	with	IN
cord-018265-twp33bb6	256	18	recombinant	recombinant	JJ
cord-018265-twp33bb6	256	19	VLP	VLP	NNP
cord-018265-twp33bb6	256	20	showed	show	VBD
cord-018265-twp33bb6	256	21	only	only	RB
cord-018265-twp33bb6	256	22	partial	partial	JJ
cord-018265-twp33bb6	256	23	protection	protection	NN
cord-018265-twp33bb6	256	24	[	[	-LRB-
cord-018265-twp33bb6	256	25	84	84	CD
cord-018265-twp33bb6	256	26	]	]	-RRB-
cord-018265-twp33bb6	256	27	.	.	.
cord-018265-twp33bb6	257	1	Recent	recent	JJ
cord-018265-twp33bb6	257	2	studies	study	NNS
cord-018265-twp33bb6	257	3	also	also	RB
cord-018265-twp33bb6	257	4	suggested	suggest	VBD
cord-018265-twp33bb6	257	5	that	that	IN
cord-018265-twp33bb6	257	6	CTL	CTL	NNP
cord-018265-twp33bb6	257	7	responses	response	NNS
cord-018265-twp33bb6	257	8	play	play	VBP
cord-018265-twp33bb6	257	9	a	a	DT
cord-018265-twp33bb6	257	10	role	role	NN
cord-018265-twp33bb6	257	11	in	in	IN
cord-018265-twp33bb6	257	12	protection	protection	NN
cord-018265-twp33bb6	257	13	and	and	CC
cord-018265-twp33bb6	257	14	clearance	clearance	NN
cord-018265-twp33bb6	257	15	[	[	-LRB-
cord-018265-twp33bb6	257	16	85	85	CD
cord-018265-twp33bb6	257	17	]	]	-RRB-
cord-018265-twp33bb6	257	18	.	.	.
cord-018265-twp33bb6	258	1	Animals	animal	NNS
cord-018265-twp33bb6	258	2	immunized	immunize	VBN
cord-018265-twp33bb6	258	3	with	with	IN
cord-018265-twp33bb6	258	4	a	a	DT
cord-018265-twp33bb6	258	5	mini	mini	JJ
cord-018265-twp33bb6	258	6	-	-	NN
cord-018265-twp33bb6	258	7	gene	gene	NN
cord-018265-twp33bb6	258	8	encoding	encode	VBG
cord-018265-twp33bb6	258	9	seven	seven	CD
cord-018265-twp33bb6	258	10	H-2(b)-restricted	H-2(b)-restricted	NNP
cord-018265-twp33bb6	258	11	CTL	CTL	NNP
cord-018265-twp33bb6	258	12	epitopes	epitope	NNS
cord-018265-twp33bb6	258	13	fused	fuse	VBN
cord-018265-twp33bb6	258	14	to	to	IN
cord-018265-twp33bb6	258	15	a	a	DT
cord-018265-twp33bb6	258	16	endothelial	endothelial	JJ
cord-018265-twp33bb6	258	17	reticulum	reticulum	NN
cord-018265-twp33bb6	258	18	-	-	HYPH
cord-018265-twp33bb6	258	19	translocation	translocation	NN
cord-018265-twp33bb6	258	20	signal	signal	NN
cord-018265-twp33bb6	258	21	showed	show	VBD
cord-018265-twp33bb6	258	22	protection	protection	NN
cord-018265-twp33bb6	258	23	following	follow	VBG
cord-018265-twp33bb6	258	24	intranasal	intranasal	NN
cord-018265-twp33bb6	258	25	challenge	challenge	NN
cord-018265-twp33bb6	258	26	with	with	IN
cord-018265-twp33bb6	258	27	a	a	DT
cord-018265-twp33bb6	258	28	virulent	virulent	JJ
cord-018265-twp33bb6	258	29	C.	C.	NNP
cord-018265-twp33bb6	258	30	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	258	31	[	[	-LRB-
cord-018265-twp33bb6	258	32	85	85	CD
cord-018265-twp33bb6	258	33	]	]	-RRB-
cord-018265-twp33bb6	258	34	.	.	.
cord-018265-twp33bb6	259	1	The	the	DT
cord-018265-twp33bb6	259	2	current	current	JJ
cord-018265-twp33bb6	259	3	view	view	NN
cord-018265-twp33bb6	259	4	is	be	VBZ
cord-018265-twp33bb6	259	5	that	that	IN
cord-018265-twp33bb6	259	6	multi	multi	JJ
cord-018265-twp33bb6	259	7	-	-	JJ
cord-018265-twp33bb6	259	8	component	component	JJ
cord-018265-twp33bb6	259	9	vaccine	vaccine	NN
cord-018265-twp33bb6	259	10	will	will	MD
cord-018265-twp33bb6	259	11	be	be	VB
cord-018265-twp33bb6	259	12	required	require	VBN
cord-018265-twp33bb6	259	13	in	in	IN
cord-018265-twp33bb6	259	14	order	order	NN
cord-018265-twp33bb6	259	15	to	to	TO
cord-018265-twp33bb6	259	16	induce	induce	VB
cord-018265-twp33bb6	259	17	a	a	DT
cord-018265-twp33bb6	259	18	protective	protective	JJ
cord-018265-twp33bb6	259	19	response	response	NN
cord-018265-twp33bb6	259	20	[	[	-LRB-
cord-018265-twp33bb6	259	21	86	86	CD
cord-018265-twp33bb6	259	22	]	]	-RRB-
cord-018265-twp33bb6	259	23	.	.	.
cord-018265-twp33bb6	260	1	Using	use	VBG
cord-018265-twp33bb6	260	2	the	the	DT
cord-018265-twp33bb6	260	3	promising	promising	JJ
cord-018265-twp33bb6	260	4	approach	approach	NN
cord-018265-twp33bb6	260	5	of	of	IN
cord-018265-twp33bb6	260	6	reverse	reverse	JJ
cord-018265-twp33bb6	260	7	vaccinology	vaccinology	NN
cord-018265-twp33bb6	260	8	combined	combine	VBN
cord-018265-twp33bb6	260	9	with	with	IN
cord-018265-twp33bb6	260	10	proteomics	proteomic	NNS
cord-018265-twp33bb6	260	11	(	(	-LRB-
cord-018265-twp33bb6	260	12	see	see	VB
cord-018265-twp33bb6	260	13	section	section	NN
cord-018265-twp33bb6	260	14	"	"	``
cord-018265-twp33bb6	260	15	Reverse	Reverse	NNP
cord-018265-twp33bb6	260	16	vaccinology	vaccinology	NN
cord-018265-twp33bb6	260	17	"	"	''
cord-018265-twp33bb6	260	18	)	)	-RRB-
cord-018265-twp33bb6	260	19	,	,	,
cord-018265-twp33bb6	260	20	the	the	DT
cord-018265-twp33bb6	260	21	whole	whole	JJ
cord-018265-twp33bb6	260	22	-	-	HYPH
cord-018265-twp33bb6	260	23	genome	genome	NN
cord-018265-twp33bb6	260	24	of	of	IN
cord-018265-twp33bb6	260	25	C.	C.	NNP
cord-018265-twp33bb6	260	26	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	260	27	was	be	VBD
cord-018265-twp33bb6	260	28	screened	screen	VBN
cord-018265-twp33bb6	260	29	searching	search	VBG
cord-018265-twp33bb6	260	30	for	for	IN
cord-018265-twp33bb6	260	31	vaccine	vaccine	NN
cord-018265-twp33bb6	260	32	candidate	candidate	NN
cord-018265-twp33bb6	260	33	antigens	antigen	NNS
cord-018265-twp33bb6	260	34	among	among	IN
cord-018265-twp33bb6	260	35	exposed	expose	VBN
cord-018265-twp33bb6	260	36	and	and	CC
cord-018265-twp33bb6	260	37	immune	immune	JJ
cord-018265-twp33bb6	260	38	accessible	accessible	JJ
cord-018265-twp33bb6	260	39	surface	surface	NN
cord-018265-twp33bb6	260	40	proteins	protein	NNS
cord-018265-twp33bb6	260	41	[	[	-LRB-
cord-018265-twp33bb6	260	42	87	87	CD
cord-018265-twp33bb6	260	43	]	]	-RRB-
cord-018265-twp33bb6	260	44	.	.	.
cord-018265-twp33bb6	261	1	The	the	DT
cord-018265-twp33bb6	261	2	selected	select	VBN
cord-018265-twp33bb6	261	3	candidates	candidate	NNS
cord-018265-twp33bb6	261	4	were	be	VBD
cord-018265-twp33bb6	261	5	then	then	RB
cord-018265-twp33bb6	261	6	expressed	express	VBN
cord-018265-twp33bb6	261	7	in	in	IN
cord-018265-twp33bb6	261	8	a	a	DT
cord-018265-twp33bb6	261	9	heterologous	heterologous	JJ
cord-018265-twp33bb6	261	10	system	system	NN
cord-018265-twp33bb6	261	11	and	and	CC
cord-018265-twp33bb6	261	12	used	use	VBN
cord-018265-twp33bb6	261	13	in	in	IN
cord-018265-twp33bb6	261	14	immunization	immunization	NN
cord-018265-twp33bb6	261	15	studies	study	NNS
cord-018265-twp33bb6	261	16	.	.	.
cord-018265-twp33bb6	262	1	Approximately	approximately	RB
cord-018265-twp33bb6	262	2	53	53	CD
cord-018265-twp33bb6	262	3	proteins	protein	NNS
cord-018265-twp33bb6	262	4	were	be	VBD
cord-018265-twp33bb6	262	5	able	able	JJ
cord-018265-twp33bb6	262	6	to	to	TO
cord-018265-twp33bb6	262	7	trigger	trigger	VB
cord-018265-twp33bb6	262	8	the	the	DT
cord-018265-twp33bb6	262	9	elicitation	elicitation	NN
cord-018265-twp33bb6	262	10	of	of	IN
cord-018265-twp33bb6	262	11	C.	C.	NNP
cord-018265-twp33bb6	262	12	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	262	13	-	-	HYPH
cord-018265-twp33bb6	262	14	binding	bind	VBG
cord-018265-twp33bb6	262	15	antibodies	antibody	NNS
cord-018265-twp33bb6	262	16	.	.	.
cord-018265-twp33bb6	263	1	When	when	WRB
cord-018265-twp33bb6	263	2	tested	test	VBN
cord-018265-twp33bb6	263	3	in	in	IN
cord-018265-twp33bb6	263	4	secondary	secondary	JJ
cord-018265-twp33bb6	263	5	screenings	screening	NNS
cord-018265-twp33bb6	263	6	,	,	,
cord-018265-twp33bb6	263	7	six	six	CD
cord-018265-twp33bb6	263	8	of	of	IN
cord-018265-twp33bb6	263	9	them	-PRON-	PRP
cord-018265-twp33bb6	263	10	were	be	VBD
cord-018265-twp33bb6	263	11	also	also	RB
cord-018265-twp33bb6	263	12	able	able	JJ
cord-018265-twp33bb6	263	13	to	to	TO
cord-018265-twp33bb6	263	14	neutralize	neutralize	VB
cord-018265-twp33bb6	263	15	bacteria	bacteria	NNS
cord-018265-twp33bb6	263	16	in	in	IN
cord-018265-twp33bb6	263	17	vitro	vitro	FW
cord-018265-twp33bb6	263	18	,	,	,
cord-018265-twp33bb6	263	19	and	and	CC
cord-018265-twp33bb6	263	20	four	four	CD
cord-018265-twp33bb6	263	21	inhibited	inhibited	JJ
cord-018265-twp33bb6	263	22	systemic	systemic	JJ
cord-018265-twp33bb6	263	23	dissemination	dissemination	NN
cord-018265-twp33bb6	263	24	of	of	IN
cord-018265-twp33bb6	263	25	C.	C.	NNP
cord-018265-twp33bb6	263	26	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	263	27	in	in	IN
cord-018265-twp33bb6	263	28	a	a	DT
cord-018265-twp33bb6	263	29	hamster	hamster	NN
cord-018265-twp33bb6	263	30	model	model	NN
cord-018265-twp33bb6	263	31	[	[	-LRB-
cord-018265-twp33bb6	263	32	86	86	CD
cord-018265-twp33bb6	263	33	]	]	-RRB-
cord-018265-twp33bb6	263	34	.	.	.
cord-018265-twp33bb6	264	1	Moraxella	Moraxella	NNP
cord-018265-twp33bb6	264	2	catarrhalis	catarrhalis	NNP
cord-018265-twp33bb6	264	3	is	be	VBZ
cord-018265-twp33bb6	264	4	the	the	DT
cord-018265-twp33bb6	264	5	third	third	JJ
cord-018265-twp33bb6	264	6	most	most	RBS
cord-018265-twp33bb6	264	7	common	common	JJ
cord-018265-twp33bb6	264	8	bacterial	bacterial	JJ
cord-018265-twp33bb6	264	9	etiologic	etiologic	JJ
cord-018265-twp33bb6	264	10	agent	agent	NN
cord-018265-twp33bb6	264	11	of	of	IN
cord-018265-twp33bb6	264	12	otitis	otitis	NN
cord-018265-twp33bb6	264	13	media	medium	NNS
cord-018265-twp33bb6	264	14	in	in	IN
cord-018265-twp33bb6	264	15	children	child	NNS
cord-018265-twp33bb6	264	16	.	.	.
cord-018265-twp33bb6	265	1	Furthermore	furthermore	RB
cord-018265-twp33bb6	265	2	,	,	,
cord-018265-twp33bb6	265	3	M.	M.	NNP
cord-018265-twp33bb6	265	4	catarrhalis	catarrhalis	NNP
cord-018265-twp33bb6	265	5	is	be	VBZ
cord-018265-twp33bb6	265	6	an	an	DT
cord-018265-twp33bb6	265	7	important	important	JJ
cord-018265-twp33bb6	265	8	cause	cause	NN
cord-018265-twp33bb6	265	9	of	of	IN
cord-018265-twp33bb6	265	10	respiratory	respiratory	JJ
cord-018265-twp33bb6	265	11	infections	infection	NNS
cord-018265-twp33bb6	265	12	in	in	IN
cord-018265-twp33bb6	265	13	patients	patient	NNS
cord-018265-twp33bb6	265	14	with	with	IN
cord-018265-twp33bb6	265	15	COPD	COPD	NNP
cord-018265-twp33bb6	265	16	.	.	.
cord-018265-twp33bb6	266	1	Thus	thus	RB
cord-018265-twp33bb6	266	2	,	,	,
cord-018265-twp33bb6	266	3	different	different	JJ
cord-018265-twp33bb6	266	4	studies	study	NNS
cord-018265-twp33bb6	266	5	have	have	VBP
cord-018265-twp33bb6	266	6	been	be	VBN
cord-018265-twp33bb6	266	7	carried	carry	VBN
cord-018265-twp33bb6	266	8	out	out	RP
cord-018265-twp33bb6	266	9	to	to	TO
cord-018265-twp33bb6	266	10	characterize	characterize	VB
cord-018265-twp33bb6	266	11	potential	potential	JJ
cord-018265-twp33bb6	266	12	protective	protective	JJ
cord-018265-twp33bb6	266	13	antigens	antigen	NNS
cord-018265-twp33bb6	266	14	.	.	.
cord-018265-twp33bb6	267	1	In	in	IN
cord-018265-twp33bb6	267	2	this	this	DT
cord-018265-twp33bb6	267	3	context	context	NN
cord-018265-twp33bb6	267	4	,	,	,
cord-018265-twp33bb6	267	5	two	two	CD
cord-018265-twp33bb6	267	6	major	major	JJ
cord-018265-twp33bb6	267	7	OMP	OMP	NNP
cord-018265-twp33bb6	267	8	(	(	-LRB-
cord-018265-twp33bb6	267	9	CD	CD	NNP
cord-018265-twp33bb6	267	10	and	and	CC
cord-018265-twp33bb6	267	11	E	E	NNP
cord-018265-twp33bb6	267	12	)	)	-RRB-
cord-018265-twp33bb6	267	13	have	have	VBP
cord-018265-twp33bb6	267	14	been	be	VBN
cord-018265-twp33bb6	267	15	identified	identify	VBN
cord-018265-twp33bb6	267	16	,	,	,
cord-018265-twp33bb6	267	17	which	which	WDT
cord-018265-twp33bb6	267	18	are	be	VBP
cord-018265-twp33bb6	267	19	considered	consider	VBN
cord-018265-twp33bb6	267	20	prime	prime	JJ
cord-018265-twp33bb6	267	21	candidate	candidate	NN
cord-018265-twp33bb6	267	22	antigens	antigen	NNS
cord-018265-twp33bb6	267	23	for	for	IN
cord-018265-twp33bb6	267	24	vaccine	vaccine	NN
cord-018265-twp33bb6	267	25	development	development	NN
cord-018265-twp33bb6	267	26	.	.	.
cord-018265-twp33bb6	268	1	These	these	DT
cord-018265-twp33bb6	268	2	proteins	protein	NNS
cord-018265-twp33bb6	268	3	are	be	VBP
cord-018265-twp33bb6	268	4	expressed	express	VBN
cord-018265-twp33bb6	268	5	on	on	IN
cord-018265-twp33bb6	268	6	the	the	DT
cord-018265-twp33bb6	268	7	surface	surface	NN
cord-018265-twp33bb6	268	8	and	and	CC
cord-018265-twp33bb6	268	9	show	show	VBP
cord-018265-twp33bb6	268	10	a	a	DT
cord-018265-twp33bb6	268	11	high	high	JJ
cord-018265-twp33bb6	268	12	degree	degree	NN
cord-018265-twp33bb6	268	13	of	of	IN
cord-018265-twp33bb6	268	14	conservation	conservation	NN
cord-018265-twp33bb6	268	15	among	among	IN
cord-018265-twp33bb6	268	16	circulating	circulate	VBG
cord-018265-twp33bb6	268	17	strains	strain	NNS
cord-018265-twp33bb6	268	18	.	.	.
cord-018265-twp33bb6	269	1	Both	both	DT
cord-018265-twp33bb6	269	2	OMP	OMP	NNP
cord-018265-twp33bb6	269	3	triggered	trigger	VBD
cord-018265-twp33bb6	269	4	the	the	DT
cord-018265-twp33bb6	269	5	elicitation	elicitation	NN
cord-018265-twp33bb6	269	6	of	of	IN
cord-018265-twp33bb6	269	7	bactericidal	bactericidal	JJ
cord-018265-twp33bb6	269	8	antibodies	antibody	NNS
cord-018265-twp33bb6	269	9	and	and	CC
cord-018265-twp33bb6	269	10	protective	protective	JJ
cord-018265-twp33bb6	269	11	immunity	immunity	NN
cord-018265-twp33bb6	269	12	in	in	IN
cord-018265-twp33bb6	269	13	preclinical	preclinical	JJ
cord-018265-twp33bb6	269	14	models	model	NNS
cord-018265-twp33bb6	269	15	[	[	-LRB-
cord-018265-twp33bb6	269	16	88	88	CD
cord-018265-twp33bb6	269	17	]	]	-RRB-
cord-018265-twp33bb6	269	18	.	.	.
cord-018265-twp33bb6	270	1	Additional	additional	JJ
cord-018265-twp33bb6	270	2	candidates	candidate	NNS
cord-018265-twp33bb6	270	3	are	be	VBP
cord-018265-twp33bb6	270	4	the	the	DT
cord-018265-twp33bb6	270	5	UspA1	UspA1	NNP
cord-018265-twp33bb6	270	6	protein	protein	NN
cord-018265-twp33bb6	270	7	[	[	-LRB-
cord-018265-twp33bb6	270	8	89	89	CD
cord-018265-twp33bb6	270	9	]	]	-RRB-
cord-018265-twp33bb6	270	10	,	,	,
cord-018265-twp33bb6	270	11	which	which	WDT
cord-018265-twp33bb6	270	12	seems	seem	VBZ
cord-018265-twp33bb6	270	13	to	to	TO
cord-018265-twp33bb6	270	14	be	be	VB
cord-018265-twp33bb6	270	15	required	require	VBN
cord-018265-twp33bb6	270	16	for	for	IN
cord-018265-twp33bb6	270	17	bacterial	bacterial	JJ
cord-018265-twp33bb6	270	18	colonization	colonization	NN
cord-018265-twp33bb6	270	19	of	of	IN
cord-018265-twp33bb6	270	20	the	the	DT
cord-018265-twp33bb6	270	21	human	human	JJ
cord-018265-twp33bb6	270	22	upper	upper	JJ
cord-018265-twp33bb6	270	23	respiratory	respiratory	JJ
cord-018265-twp33bb6	270	24	tract	tract	NN
cord-018265-twp33bb6	270	25	,	,	,
cord-018265-twp33bb6	270	26	the	the	DT
cord-018265-twp33bb6	270	27	iron	iron	NN
cord-018265-twp33bb6	270	28	-	-	HYPH
cord-018265-twp33bb6	270	29	induced	induce	VBN
cord-018265-twp33bb6	270	30	OMP	omp	NN
cord-018265-twp33bb6	270	31	B1	b1	NN
cord-018265-twp33bb6	270	32	and	and	CC
cord-018265-twp33bb6	270	33	LBP	LBP	NNP
cord-018265-twp33bb6	270	34	,	,	,
cord-018265-twp33bb6	270	35	and	and	CC
cord-018265-twp33bb6	270	36	the	the	DT
cord-018265-twp33bb6	270	37	iron	iron	NN
cord-018265-twp33bb6	270	38	-	-	HYPH
cord-018265-twp33bb6	270	39	repressed	repress	VBN
cord-018265-twp33bb6	270	40	OMP	OMP	NNP
cord-018265-twp33bb6	270	41	B2	b2	NN
cord-018265-twp33bb6	270	42	[	[	-LRB-
cord-018265-twp33bb6	270	43	90	90	CD
cord-018265-twp33bb6	270	44	]	]	-RRB-
cord-018265-twp33bb6	270	45	.	.	.
cord-018265-twp33bb6	271	1	A	a	DT
cord-018265-twp33bb6	271	2	conjugate	conjugate	JJ
cord-018265-twp33bb6	271	3	vaccine	vaccine	NN
cord-018265-twp33bb6	271	4	based	base	VBN
cord-018265-twp33bb6	271	5	on	on	IN
cord-018265-twp33bb6	271	6	detoxified	detoxify	VBN
cord-018265-twp33bb6	271	7	lipo	lipo	NN
cord-018265-twp33bb6	271	8	-	-	HYPH
cord-018265-twp33bb6	271	9	oligosaccharide	oligosaccharide	NN
cord-018265-twp33bb6	271	10	was	be	VBD
cord-018265-twp33bb6	271	11	also	also	RB
cord-018265-twp33bb6	271	12	tested	test	VBN
cord-018265-twp33bb6	271	13	in	in	IN
cord-018265-twp33bb6	271	14	mice	mouse	NNS
cord-018265-twp33bb6	271	15	by	by	IN
cord-018265-twp33bb6	271	16	intranasal	intranasal	NN
cord-018265-twp33bb6	271	17	route	route	NN
cord-018265-twp33bb6	271	18	with	with	IN
cord-018265-twp33bb6	271	19	encouraging	encouraging	JJ
cord-018265-twp33bb6	271	20	results	result	NNS
cord-018265-twp33bb6	271	21	[	[	-LRB-
cord-018265-twp33bb6	271	22	91	91	CD
cord-018265-twp33bb6	271	23	,	,	,
cord-018265-twp33bb6	271	24	92	92	CD
cord-018265-twp33bb6	271	25	]	]	-RRB-
cord-018265-twp33bb6	271	26	.	.	.
cord-018265-twp33bb6	272	1	Some	some	DT
cord-018265-twp33bb6	272	2	of	of	IN
cord-018265-twp33bb6	272	3	these	these	DT
cord-018265-twp33bb6	272	4	candidates	candidate	NNS
cord-018265-twp33bb6	272	5	are	be	VBP
cord-018265-twp33bb6	272	6	planned	plan	VBN
cord-018265-twp33bb6	272	7	to	to	TO
cord-018265-twp33bb6	272	8	be	be	VB
cord-018265-twp33bb6	272	9	tested	test	VBN
cord-018265-twp33bb6	272	10	in	in	IN
cord-018265-twp33bb6	272	11	clinical	clinical	JJ
cord-018265-twp33bb6	272	12	studies	study	NNS
cord-018265-twp33bb6	272	13	soon	soon	RB
cord-018265-twp33bb6	272	14	[	[	-LRB-
cord-018265-twp33bb6	272	15	90	90	CD
cord-018265-twp33bb6	272	16	]	]	-RRB-
cord-018265-twp33bb6	272	17	.	.	.
cord-018265-twp33bb6	273	1	Mycoplasmas	mycoplasma	NNS
cord-018265-twp33bb6	273	2	are	be	VBP
cord-018265-twp33bb6	273	3	commensal	commensal	JJ
cord-018265-twp33bb6	273	4	microorganisms	microorganism	NNS
cord-018265-twp33bb6	273	5	,	,	,
cord-018265-twp33bb6	273	6	as	as	RB
cord-018265-twp33bb6	273	7	well	well	RB
cord-018265-twp33bb6	273	8	as	as	IN
cord-018265-twp33bb6	273	9	opportunistic	opportunistic	JJ
cord-018265-twp33bb6	273	10	pathogens	pathogen	NNS
cord-018265-twp33bb6	273	11	.	.	.
cord-018265-twp33bb6	274	1	Mycoplasma	mycoplasma	NN
cord-018265-twp33bb6	274	2	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	274	3	is	be	VBZ
cord-018265-twp33bb6	274	4	one	one	CD
cord-018265-twp33bb6	274	5	of	of	IN
cord-018265-twp33bb6	274	6	the	the	DT
cord-018265-twp33bb6	274	7	causative	causative	JJ
cord-018265-twp33bb6	274	8	agents	agent	NNS
cord-018265-twp33bb6	274	9	of	of	IN
cord-018265-twp33bb6	274	10	acute	acute	JJ
cord-018265-twp33bb6	274	11	and	and	CC
cord-018265-twp33bb6	274	12	chronic	chronic	JJ
cord-018265-twp33bb6	274	13	human	human	JJ
cord-018265-twp33bb6	274	14	respiratory	respiratory	JJ
cord-018265-twp33bb6	274	15	diseases	disease	NNS
cord-018265-twp33bb6	274	16	and	and	CC
cord-018265-twp33bb6	274	17	the	the	DT
cord-018265-twp33bb6	274	18	main	main	JJ
cord-018265-twp33bb6	274	19	responsible	responsible	JJ
cord-018265-twp33bb6	274	20	for	for	IN
cord-018265-twp33bb6	274	21	primary	primary	JJ
cord-018265-twp33bb6	274	22	atypical	atypical	JJ
cord-018265-twp33bb6	274	23	pneumonia	pneumonia	NN
cord-018265-twp33bb6	274	24	,	,	,
cord-018265-twp33bb6	274	25	accounting	account	VBG
cord-018265-twp33bb6	274	26	for	for	IN
cord-018265-twp33bb6	274	27	approximately	approximately	RB
cord-018265-twp33bb6	274	28	20	20	CD
cord-018265-twp33bb6	274	29	-	-	SYM
cord-018265-twp33bb6	274	30	30	30	CD
cord-018265-twp33bb6	274	31	%	%	NN
cord-018265-twp33bb6	274	32	of	of	IN
cord-018265-twp33bb6	274	33	all	all	DT
cord-018265-twp33bb6	274	34	community	community	NN
cord-018265-twp33bb6	274	35	-	-	HYPH
cord-018265-twp33bb6	274	36	acquired	acquire	VBN
cord-018265-twp33bb6	274	37	pneumonia	pneumonia	NN
cord-018265-twp33bb6	274	38	[	[	-LRB-
cord-018265-twp33bb6	274	39	93	93	CD
cord-018265-twp33bb6	274	40	]	]	-RRB-
cord-018265-twp33bb6	274	41	.	.	.
cord-018265-twp33bb6	275	1	There	there	EX
cord-018265-twp33bb6	275	2	is	be	VBZ
cord-018265-twp33bb6	275	3	a	a	DT
cord-018265-twp33bb6	275	4	considerable	considerable	JJ
cord-018265-twp33bb6	275	5	underreporting	underreporting	NN
cord-018265-twp33bb6	275	6	for	for	IN
cord-018265-twp33bb6	275	7	M.	M.	NNP
cord-018265-twp33bb6	275	8	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	275	9	-	-	HYPH
cord-018265-twp33bb6	275	10	associated	associate	VBN
cord-018265-twp33bb6	275	11	diseases	disease	NNS
cord-018265-twp33bb6	275	12	.	.	.
cord-018265-twp33bb6	276	1	This	this	DT
cord-018265-twp33bb6	276	2	is	be	VBZ
cord-018265-twp33bb6	276	3	in	in	IN
cord-018265-twp33bb6	276	4	part	part	NN
cord-018265-twp33bb6	276	5	due	due	IN
cord-018265-twp33bb6	276	6	to	to	IN
cord-018265-twp33bb6	276	7	the	the	DT
cord-018265-twp33bb6	276	8	wide	wide	JJ
cord-018265-twp33bb6	276	9	diversity	diversity	NN
cord-018265-twp33bb6	276	10	of	of	IN
cord-018265-twp33bb6	276	11	clinical	clinical	JJ
cord-018265-twp33bb6	276	12	manifestations	manifestation	NNS
cord-018265-twp33bb6	276	13	,	,	,
cord-018265-twp33bb6	276	14	the	the	DT
cord-018265-twp33bb6	276	15	difficulties	difficulty	NNS
cord-018265-twp33bb6	276	16	associated	associate	VBN
cord-018265-twp33bb6	276	17	with	with	IN
cord-018265-twp33bb6	276	18	its	-PRON-	PRP$
cord-018265-twp33bb6	276	19	cultivation	cultivation	NN
cord-018265-twp33bb6	276	20	from	from	IN
cord-018265-twp33bb6	276	21	clinical	clinical	JJ
cord-018265-twp33bb6	276	22	specimens	specimen	NNS
cord-018265-twp33bb6	276	23	and	and	CC
cord-018265-twp33bb6	276	24	the	the	DT
cord-018265-twp33bb6	276	25	lack	lack	NN
cord-018265-twp33bb6	276	26	of	of	IN
cord-018265-twp33bb6	276	27	adequate	adequate	JJ
cord-018265-twp33bb6	276	28	diagnostic	diagnostic	JJ
cord-018265-twp33bb6	276	29	tools	tool	NNS
cord-018265-twp33bb6	276	30	.	.	.
cord-018265-twp33bb6	277	1	No	no	DT
cord-018265-twp33bb6	277	2	vaccines	vaccine	NNS
cord-018265-twp33bb6	277	3	are	be	VBP
cord-018265-twp33bb6	277	4	currently	currently	RB
cord-018265-twp33bb6	277	5	available	available	JJ
cord-018265-twp33bb6	277	6	against	against	IN
cord-018265-twp33bb6	277	7	this	this	DT
cord-018265-twp33bb6	277	8	pathogen	pathogen	NN
cord-018265-twp33bb6	277	9	.	.	.
cord-018265-twp33bb6	278	1	However	however	RB
cord-018265-twp33bb6	278	2	,	,	,
cord-018265-twp33bb6	278	3	studies	study	NNS
cord-018265-twp33bb6	278	4	conducted	conduct	VBN
cord-018265-twp33bb6	278	5	in	in	IN
cord-018265-twp33bb6	278	6	human	human	JJ
cord-018265-twp33bb6	278	7	volunteers	volunteer	NNS
cord-018265-twp33bb6	278	8	in	in	IN
cord-018265-twp33bb6	278	9	the	the	DT
cord-018265-twp33bb6	278	10	late	late	JJ
cord-018265-twp33bb6	278	11	1960s	1960	NNS
cord-018265-twp33bb6	278	12	demonstrated	demonstrate	VBD
cord-018265-twp33bb6	278	13	that	that	IN
cord-018265-twp33bb6	278	14	a	a	DT
cord-018265-twp33bb6	278	15	formalin	formalin	NN
cord-018265-twp33bb6	278	16	-	-	HYPH
cord-018265-twp33bb6	278	17	inactivated	inactivate	VBN
cord-018265-twp33bb6	278	18	whole	whole	JJ
cord-018265-twp33bb6	278	19	cell	cell	NN
cord-018265-twp33bb6	278	20	vaccine	vaccine	NN
cord-018265-twp33bb6	278	21	and	and	CC
cord-018265-twp33bb6	278	22	an	an	DT
cord-018265-twp33bb6	278	23	acellular	acellular	JJ
cord-018265-twp33bb6	278	24	extract	extract	NN
cord-018265-twp33bb6	278	25	were	be	VBD
cord-018265-twp33bb6	278	26	able	able	JJ
cord-018265-twp33bb6	278	27	to	to	TO
cord-018265-twp33bb6	278	28	confer	confer	VB
cord-018265-twp33bb6	278	29	moderately	moderately	RB
cord-018265-twp33bb6	278	30	protective	protective	JJ
cord-018265-twp33bb6	278	31	immunity	immunity	NN
cord-018265-twp33bb6	278	32	against	against	IN
cord-018265-twp33bb6	278	33	M.	M.	NNP
cord-018265-twp33bb6	278	34	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	278	35	[	[	-LRB-
cord-018265-twp33bb6	278	36	94	94	CD
cord-018265-twp33bb6	278	37	]	]	-RRB-
cord-018265-twp33bb6	278	38	.	.	.
cord-018265-twp33bb6	279	1	Unfortunately	unfortunately	RB
cord-018265-twp33bb6	279	2	,	,	,
cord-018265-twp33bb6	279	3	immune	immune	JJ
cord-018265-twp33bb6	279	4	pathological	pathological	JJ
cord-018265-twp33bb6	279	5	reactions	reaction	NNS
cord-018265-twp33bb6	279	6	were	be	VBD
cord-018265-twp33bb6	279	7	observed	observe	VBN
cord-018265-twp33bb6	279	8	following	follow	VBG
cord-018265-twp33bb6	279	9	challenge	challenge	NN
cord-018265-twp33bb6	279	10	with	with	IN
cord-018265-twp33bb6	279	11	live	live	JJ
cord-018265-twp33bb6	279	12	organisms	organism	NNS
cord-018265-twp33bb6	279	13	.	.	.
cord-018265-twp33bb6	280	1	Therefore	therefore	RB
cord-018265-twp33bb6	280	2	,	,	,
cord-018265-twp33bb6	280	3	studies	study	NNS
cord-018265-twp33bb6	280	4	are	be	VBP
cord-018265-twp33bb6	280	5	still	still	RB
cord-018265-twp33bb6	280	6	needed	need	VBN
cord-018265-twp33bb6	280	7	to	to	TO
cord-018265-twp33bb6	280	8	understand	understand	VB
cord-018265-twp33bb6	280	9	the	the	DT
cord-018265-twp33bb6	280	10	underlying	underlie	VBG
cord-018265-twp33bb6	280	11	mechanisms	mechanism	NNS
cord-018265-twp33bb6	280	12	to	to	IN
cord-018265-twp33bb6	280	13	the	the	DT
cord-018265-twp33bb6	280	14	observed	observed	JJ
cord-018265-twp33bb6	280	15	autoimmune	autoimmune	JJ
cord-018265-twp33bb6	280	16	responses	response	NNS
cord-018265-twp33bb6	280	17	[	[	-LRB-
cord-018265-twp33bb6	280	18	95	95	CD
cord-018265-twp33bb6	280	19	]	]	-RRB-
cord-018265-twp33bb6	280	20	.	.	.
cord-018265-twp33bb6	281	1	More	more	RBR
cord-018265-twp33bb6	281	2	specifically	specifically	RB
cord-018265-twp33bb6	281	3	,	,	,
cord-018265-twp33bb6	281	4	we	-PRON-	PRP
cord-018265-twp33bb6	281	5	need	need	VBP
cord-018265-twp33bb6	281	6	to	to	TO
cord-018265-twp33bb6	281	7	elucidate	elucidate	VB
cord-018265-twp33bb6	281	8	the	the	DT
cord-018265-twp33bb6	281	9	specific	specific	JJ
cord-018265-twp33bb6	281	10	role	role	NN
cord-018265-twp33bb6	281	11	played	play	VBN
cord-018265-twp33bb6	281	12	by	by	IN
cord-018265-twp33bb6	281	13	humoral	humoral	JJ
cord-018265-twp33bb6	281	14	and	and	CC
cord-018265-twp33bb6	281	15	cellular	cellular	JJ
cord-018265-twp33bb6	281	16	response	response	NN
cord-018265-twp33bb6	281	17	in	in	IN
cord-018265-twp33bb6	281	18	protection	protection	NN
cord-018265-twp33bb6	281	19	against	against	IN
cord-018265-twp33bb6	281	20	M.	M.	NNP
cord-018265-twp33bb6	281	21	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	281	22	.	.	.
cord-018265-twp33bb6	282	1	M.	M.	NNP
cord-018265-twp33bb6	282	2	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	282	3	is	be	VBZ
cord-018265-twp33bb6	282	4	one	one	CD
cord-018265-twp33bb6	282	5	of	of	IN
cord-018265-twp33bb6	282	6	the	the	DT
cord-018265-twp33bb6	282	7	smallest	small	JJS
cord-018265-twp33bb6	282	8	self	self	NN
cord-018265-twp33bb6	282	9	-	-	HYPH
cord-018265-twp33bb6	282	10	replicating	replicate	VBG
cord-018265-twp33bb6	282	11	prokaryotic	prokaryotic	JJ
cord-018265-twp33bb6	282	12	pathogens	pathogen	NNS
cord-018265-twp33bb6	282	13	(	(	-LRB-
cord-018265-twp33bb6	282	14	approximately	approximately	RB
cord-018265-twp33bb6	282	15	800	800	CD
cord-018265-twp33bb6	282	16	kb	kb	NNP
cord-018265-twp33bb6	282	17	)	)	-RRB-
cord-018265-twp33bb6	282	18	.	.	.
cord-018265-twp33bb6	283	1	The	the	DT
cord-018265-twp33bb6	283	2	complete	complete	JJ
cord-018265-twp33bb6	283	3	genome	genome	NN
cord-018265-twp33bb6	283	4	sequence	sequence	NN
cord-018265-twp33bb6	283	5	is	be	VBZ
cord-018265-twp33bb6	283	6	now	now	RB
cord-018265-twp33bb6	283	7	available	available	JJ
cord-018265-twp33bb6	283	8	.	.	.
cord-018265-twp33bb6	284	1	This	this	DT
cord-018265-twp33bb6	284	2	is	be	VBZ
cord-018265-twp33bb6	284	3	expected	expect	VBN
cord-018265-twp33bb6	284	4	to	to	TO
cord-018265-twp33bb6	284	5	expand	expand	VB
cord-018265-twp33bb6	284	6	our	-PRON-	PRP$
cord-018265-twp33bb6	284	7	knowledge	knowledge	NN
cord-018265-twp33bb6	284	8	on	on	IN
cord-018265-twp33bb6	284	9	the	the	DT
cord-018265-twp33bb6	284	10	physiological	physiological	JJ
cord-018265-twp33bb6	284	11	and	and	CC
cord-018265-twp33bb6	284	12	virulence	virulence	NN
cord-018265-twp33bb6	284	13	properties	property	NNS
cord-018265-twp33bb6	284	14	of	of	IN
cord-018265-twp33bb6	284	15	this	this	DT
cord-018265-twp33bb6	284	16	agent	agent	NN
cord-018265-twp33bb6	284	17	,	,	,
cord-018265-twp33bb6	284	18	as	as	RB
cord-018265-twp33bb6	284	19	well	well	RB
cord-018265-twp33bb6	284	20	as	as	IN
cord-018265-twp33bb6	284	21	new	new	JJ
cord-018265-twp33bb6	284	22	hints	hint	NNS
cord-018265-twp33bb6	284	23	for	for	IN
cord-018265-twp33bb6	284	24	vaccine	vaccine	NN
cord-018265-twp33bb6	284	25	development	development	NN
cord-018265-twp33bb6	284	26	.	.	.
cord-018265-twp33bb6	285	1	A	a	DT
cord-018265-twp33bb6	285	2	previously	previously	RB
cord-018265-twp33bb6	285	3	unrecognized	unrecognized	JJ
cord-018265-twp33bb6	285	4	bacterium	bacterium	NN
cord-018265-twp33bb6	285	5	was	be	VBD
cord-018265-twp33bb6	285	6	isolated	isolate	VBN
cord-018265-twp33bb6	285	7	after	after	IN
cord-018265-twp33bb6	285	8	the	the	DT
cord-018265-twp33bb6	285	9	outbreak	outbreak	NN
cord-018265-twp33bb6	285	10	of	of	IN
cord-018265-twp33bb6	285	11	Legionnaires	Legionnaires	NNP
cord-018265-twp33bb6	285	12	disease	disease	NN
cord-018265-twp33bb6	285	13	in	in	IN
cord-018265-twp33bb6	285	14	1976	1976	CD
cord-018265-twp33bb6	285	15	,	,	,
cord-018265-twp33bb6	285	16	which	which	WDT
cord-018265-twp33bb6	285	17	was	be	VBD
cord-018265-twp33bb6	285	18	designated	designate	VBN
cord-018265-twp33bb6	285	19	Legionella	Legionella	NNP
cord-018265-twp33bb6	285	20	pneumophila	pneumophila	NN
cord-018265-twp33bb6	285	21	[	[	-LRB-
cord-018265-twp33bb6	285	22	96	96	CD
cord-018265-twp33bb6	285	23	,	,	,
cord-018265-twp33bb6	285	24	97	97	CD
cord-018265-twp33bb6	285	25	]	]	-RRB-
cord-018265-twp33bb6	285	26	.	.	.
cord-018265-twp33bb6	286	1	The	the	DT
cord-018265-twp33bb6	286	2	spreading	spreading	NN
cord-018265-twp33bb6	286	3	of	of	IN
cord-018265-twp33bb6	286	4	L.	L.	NNP
cord-018265-twp33bb6	286	5	pneumophila	pneumophila	NN
cord-018265-twp33bb6	286	6	is	be	VBZ
cord-018265-twp33bb6	286	7	increasing	increase	VBG
cord-018265-twp33bb6	286	8	due	due	IN
cord-018265-twp33bb6	286	9	to	to	IN
cord-018265-twp33bb6	286	10	the	the	DT
cord-018265-twp33bb6	286	11	use	use	NN
cord-018265-twp33bb6	286	12	of	of	IN
cord-018265-twp33bb6	286	13	air	air	NN
cord-018265-twp33bb6	286	14	-	-	HYPH
cord-018265-twp33bb6	286	15	conditioners	conditioner	NNS
cord-018265-twp33bb6	286	16	and	and	CC
cord-018265-twp33bb6	286	17	humidifiers	humidifier	NNS
cord-018265-twp33bb6	286	18	,	,	,
cord-018265-twp33bb6	286	19	since	since	IN
cord-018265-twp33bb6	286	20	infections	infection	NNS
cord-018265-twp33bb6	286	21	can	can	MD
cord-018265-twp33bb6	286	22	occur	occur	VB
cord-018265-twp33bb6	286	23	by	by	IN
cord-018265-twp33bb6	286	24	inhalation	inhalation	NN
cord-018265-twp33bb6	286	25	of	of	IN
cord-018265-twp33bb6	286	26	aerosolized	aerosolize	VBN
cord-018265-twp33bb6	286	27	contaminated	contaminated	JJ
cord-018265-twp33bb6	286	28	water	water	NN
cord-018265-twp33bb6	286	29	sources	source	NNS
cord-018265-twp33bb6	286	30	.	.	.
cord-018265-twp33bb6	287	1	Several	several	JJ
cord-018265-twp33bb6	287	2	approaches	approach	NNS
cord-018265-twp33bb6	287	3	have	have	VBP
cord-018265-twp33bb6	287	4	been	be	VBN
cord-018265-twp33bb6	287	5	developed	develop	VBN
cord-018265-twp33bb6	287	6	in	in	IN
cord-018265-twp33bb6	287	7	the	the	DT
cord-018265-twp33bb6	287	8	fight	fight	NN
cord-018265-twp33bb6	287	9	against	against	IN
cord-018265-twp33bb6	287	10	this	this	DT
cord-018265-twp33bb6	287	11	facultative	facultative	JJ
cord-018265-twp33bb6	287	12	intracellular	intracellular	JJ
cord-018265-twp33bb6	287	13	pathogen	pathogen	NN
cord-018265-twp33bb6	287	14	.	.	.
cord-018265-twp33bb6	288	1	Infection	infection	NN
cord-018265-twp33bb6	288	2	and	and	CC
cord-018265-twp33bb6	288	3	immunization	immunization	NN
cord-018265-twp33bb6	288	4	induce	induce	VBP
cord-018265-twp33bb6	288	5	a	a	DT
cord-018265-twp33bb6	288	6	rapid	rapid	JJ
cord-018265-twp33bb6	288	7	increase	increase	NN
cord-018265-twp33bb6	288	8	of	of	IN
cord-018265-twp33bb6	288	9	antibody	antibody	NN
cord-018265-twp33bb6	288	10	titres	titre	NNS
cord-018265-twp33bb6	288	11	.	.	.
cord-018265-twp33bb6	289	1	However	however	RB
cord-018265-twp33bb6	289	2	,	,	,
cord-018265-twp33bb6	289	3	antibodies	antibody	NNS
cord-018265-twp33bb6	289	4	do	do	VBP
cord-018265-twp33bb6	289	5	not	not	RB
cord-018265-twp33bb6	289	6	seem	seem	VB
cord-018265-twp33bb6	289	7	to	to	TO
cord-018265-twp33bb6	289	8	play	play	VB
cord-018265-twp33bb6	289	9	a	a	DT
cord-018265-twp33bb6	289	10	significant	significant	JJ
cord-018265-twp33bb6	289	11	role	role	NN
cord-018265-twp33bb6	289	12	in	in	IN
cord-018265-twp33bb6	289	13	host	host	NN
cord-018265-twp33bb6	289	14	resistance	resistance	NN
cord-018265-twp33bb6	289	15	,	,	,
cord-018265-twp33bb6	289	16	particularly	particularly	RB
cord-018265-twp33bb6	289	17	after	after	IN
cord-018265-twp33bb6	289	18	aerosol	aerosol	NN
cord-018265-twp33bb6	289	19	challenge	challenge	NN
cord-018265-twp33bb6	289	20	[	[	-LRB-
cord-018265-twp33bb6	289	21	98	98	CD
cord-018265-twp33bb6	289	22	]	]	-RRB-
cord-018265-twp33bb6	289	23	[	[	-LRB-
cord-018265-twp33bb6	289	24	99	99	CD
cord-018265-twp33bb6	289	25	]	]	-RRB-
cord-018265-twp33bb6	289	26	[	[	-LRB-
cord-018265-twp33bb6	289	27	100	100	CD
cord-018265-twp33bb6	289	28	]	]	-RRB-
cord-018265-twp33bb6	289	29	.	.	.
cord-018265-twp33bb6	290	1	Some	some	DT
cord-018265-twp33bb6	290	2	authors	author	NNS
cord-018265-twp33bb6	290	3	also	also	RB
cord-018265-twp33bb6	290	4	suggested	suggest	VBD
cord-018265-twp33bb6	290	5	that	that	IN
cord-018265-twp33bb6	290	6	these	these	DT
cord-018265-twp33bb6	290	7	antibodies	antibody	NNS
cord-018265-twp33bb6	290	8	can	can	MD
cord-018265-twp33bb6	290	9	promote	promote	VB
cord-018265-twp33bb6	290	10	bacterial	bacterial	JJ
cord-018265-twp33bb6	290	11	phagocytosis	phagocytosis	NN
cord-018265-twp33bb6	290	12	,	,	,
cord-018265-twp33bb6	290	13	thereby	thereby	RB
cord-018265-twp33bb6	290	14	favouring	favour	VBG
cord-018265-twp33bb6	290	15	invasion	invasion	NN
cord-018265-twp33bb6	290	16	and	and	CC
cord-018265-twp33bb6	290	17	subsequent	subsequent	JJ
cord-018265-twp33bb6	290	18	intracellular	intracellular	JJ
cord-018265-twp33bb6	290	19	replication	replication	NN
cord-018265-twp33bb6	290	20	[	[	-LRB-
cord-018265-twp33bb6	290	21	101	101	CD
cord-018265-twp33bb6	290	22	]	]	-RRB-
cord-018265-twp33bb6	290	23	.	.	.
cord-018265-twp33bb6	291	1	In	in	IN
cord-018265-twp33bb6	291	2	contrast	contrast	NN
cord-018265-twp33bb6	291	3	,	,	,
cord-018265-twp33bb6	291	4	cellular	cellular	JJ
cord-018265-twp33bb6	291	5	responses	response	NNS
cord-018265-twp33bb6	291	6	appear	appear	VBP
cord-018265-twp33bb6	291	7	to	to	TO
cord-018265-twp33bb6	291	8	be	be	VB
cord-018265-twp33bb6	291	9	important	important	JJ
cord-018265-twp33bb6	291	10	for	for	IN
cord-018265-twp33bb6	291	11	protection	protection	NN
cord-018265-twp33bb6	291	12	.	.	.
cord-018265-twp33bb6	292	1	Different	different	JJ
cord-018265-twp33bb6	292	2	vaccine	vaccine	NN
cord-018265-twp33bb6	292	3	candidates	candidate	NNS
cord-018265-twp33bb6	292	4	were	be	VBD
cord-018265-twp33bb6	292	5	tested	test	VBN
cord-018265-twp33bb6	292	6	in	in	IN
cord-018265-twp33bb6	292	7	the	the	DT
cord-018265-twp33bb6	292	8	past	past	NN
cord-018265-twp33bb6	292	9	.	.	.
cord-018265-twp33bb6	293	1	Heat-	Heat-	NNS
cord-018265-twp33bb6	293	2	,	,	,
cord-018265-twp33bb6	293	3	acetone	acetone	NN
cord-018265-twp33bb6	293	4	-	-	HYPH
cord-018265-twp33bb6	293	5	and	and	CC
cord-018265-twp33bb6	293	6	formalin	formalin	NN
cord-018265-twp33bb6	293	7	-	-	HYPH
cord-018265-twp33bb6	293	8	killed	kill	VBN
cord-018265-twp33bb6	293	9	L.	L.	NNP
cord-018265-twp33bb6	293	10	pneumophila	pneumophila	NN
cord-018265-twp33bb6	293	11	vaccines	vaccine	NNS
cord-018265-twp33bb6	293	12	were	be	VBD
cord-018265-twp33bb6	293	13	not	not	RB
cord-018265-twp33bb6	293	14	able	able	JJ
cord-018265-twp33bb6	293	15	to	to	TO
cord-018265-twp33bb6	293	16	confer	confer	VB
cord-018265-twp33bb6	293	17	protective	protective	JJ
cord-018265-twp33bb6	293	18	immunity	immunity	NN
cord-018265-twp33bb6	293	19	in	in	IN
cord-018265-twp33bb6	293	20	guinea	guinea	NN
cord-018265-twp33bb6	293	21	pigs	pig	NNS
cord-018265-twp33bb6	293	22	,	,	,
cord-018265-twp33bb6	293	23	whereas	whereas	IN
cord-018265-twp33bb6	293	24	animals	animal	NNS
cord-018265-twp33bb6	293	25	immunized	immunize	VBN
cord-018265-twp33bb6	293	26	with	with	IN
cord-018265-twp33bb6	293	27	L.	L.	NNP
cord-018265-twp33bb6	293	28	pneumophila	pneumophila	NN
cord-018265-twp33bb6	293	29	membranes	membrane	NNS
cord-018265-twp33bb6	293	30	survive	survive	VBP
cord-018265-twp33bb6	293	31	an	an	DT
cord-018265-twp33bb6	293	32	aerosol	aerosol	NN
cord-018265-twp33bb6	293	33	challenge	challenge	NN
cord-018265-twp33bb6	293	34	with	with	IN
cord-018265-twp33bb6	293	35	virulent	virulent	JJ
cord-018265-twp33bb6	293	36	bacteria	bacteria	NNS
cord-018265-twp33bb6	293	37	[	[	-LRB-
cord-018265-twp33bb6	293	38	98	98	CD
cord-018265-twp33bb6	293	39	,	,	,
cord-018265-twp33bb6	293	40	99	99	CD
cord-018265-twp33bb6	293	41	]	]	-RRB-
cord-018265-twp33bb6	293	42	.	.	.
cord-018265-twp33bb6	294	1	Additional	additional	JJ
cord-018265-twp33bb6	294	2	work	work	NN
cord-018265-twp33bb6	294	3	demonstrated	demonstrate	VBD
cord-018265-twp33bb6	294	4	that	that	IN
cord-018265-twp33bb6	294	5	also	also	RB
cord-018265-twp33bb6	294	6	purified	purify	VBN
cord-018265-twp33bb6	294	7	antigens	antigen	NNS
cord-018265-twp33bb6	294	8	,	,	,
cord-018265-twp33bb6	294	9	such	such	JJ
cord-018265-twp33bb6	294	10	as	as	IN
cord-018265-twp33bb6	294	11	the	the	DT
cord-018265-twp33bb6	294	12	major	major	JJ
cord-018265-twp33bb6	294	13	secretory	secretory	JJ
cord-018265-twp33bb6	294	14	protein	protein	NN
cord-018265-twp33bb6	294	15	[	[	-LRB-
cord-018265-twp33bb6	294	16	98	98	CD
cord-018265-twp33bb6	294	17	]	]	-RRB-
cord-018265-twp33bb6	294	18	,	,	,
cord-018265-twp33bb6	294	19	the	the	DT
cord-018265-twp33bb6	294	20	major	major	JJ
cord-018265-twp33bb6	294	21	cytoplasmatic	cytoplasmatic	JJ
cord-018265-twp33bb6	294	22	membrane	membrane	NN
cord-018265-twp33bb6	294	23	protein	protein	NN
cord-018265-twp33bb6	294	24	[	[	-LRB-
cord-018265-twp33bb6	294	25	102	102	CD
cord-018265-twp33bb6	294	26	]	]	-RRB-
cord-018265-twp33bb6	294	27	,	,	,
cord-018265-twp33bb6	294	28	the	the	DT
cord-018265-twp33bb6	294	29	peptidoglycan	peptidoglycan	NN
cord-018265-twp33bb6	294	30	-	-	HYPH
cord-018265-twp33bb6	294	31	associated	associate	VBN
cord-018265-twp33bb6	294	32	lipoprotein	lipoprotein	NN
cord-018265-twp33bb6	294	33	[	[	-LRB-
cord-018265-twp33bb6	294	34	103	103	CD
cord-018265-twp33bb6	294	35	]	]	-RRB-
cord-018265-twp33bb6	294	36	,	,	.
cord-018265-twp33bb6	295	1	OmpS	OmpS	NNP
cord-018265-twp33bb6	295	2	[	[	-LRB-
cord-018265-twp33bb6	295	3	104	104	CD
cord-018265-twp33bb6	295	4	]	]	-RRB-
cord-018265-twp33bb6	295	5	and	and	CC
cord-018265-twp33bb6	295	6	flagella	flagellum	NNS
cord-018265-twp33bb6	295	7	[	[	-LRB-
cord-018265-twp33bb6	295	8	100	100	CD
cord-018265-twp33bb6	295	9	]	]	-RRB-
cord-018265-twp33bb6	295	10	can	can	MD
cord-018265-twp33bb6	295	11	confer	confer	VB
cord-018265-twp33bb6	295	12	protection	protection	NN
cord-018265-twp33bb6	295	13	against	against	IN
cord-018265-twp33bb6	295	14	challenge	challenge	NN
cord-018265-twp33bb6	295	15	with	with	IN
cord-018265-twp33bb6	295	16	virulent	virulent	JJ
cord-018265-twp33bb6	295	17	L.	L.	NNP
cord-018265-twp33bb6	295	18	pneumophila	pneumophila	NN
cord-018265-twp33bb6	295	19	.	.	.
cord-018265-twp33bb6	296	1	Finally	finally	RB
cord-018265-twp33bb6	296	2	,	,	,
cord-018265-twp33bb6	296	3	different	different	JJ
cord-018265-twp33bb6	296	4	live	live	JJ
cord-018265-twp33bb6	296	5	attenuated	attenuated	JJ
cord-018265-twp33bb6	296	6	mutants	mutant	NNS
cord-018265-twp33bb6	296	7	of	of	IN
cord-018265-twp33bb6	296	8	L.	L.	NNP
cord-018265-twp33bb6	296	9	pneumophila	pneumophila	NN
cord-018265-twp33bb6	296	10	were	be	VBD
cord-018265-twp33bb6	296	11	used	use	VBN
cord-018265-twp33bb6	296	12	in	in	IN
cord-018265-twp33bb6	296	13	animal	animal	NN
cord-018265-twp33bb6	296	14	infection	infection	NN
cord-018265-twp33bb6	296	15	models	model	NNS
cord-018265-twp33bb6	296	16	with	with	IN
cord-018265-twp33bb6	296	17	promising	promising	JJ
cord-018265-twp33bb6	296	18	results	result	NNS
cord-018265-twp33bb6	296	19	[	[	-LRB-
cord-018265-twp33bb6	296	20	105	105	CD
cord-018265-twp33bb6	296	21	]	]	-RRB-
cord-018265-twp33bb6	296	22	.	.	.
cord-018265-twp33bb6	297	1	Cystic	cystic	JJ
cord-018265-twp33bb6	297	2	fibrosis	fibrosis	NN
cord-018265-twp33bb6	297	3	(	(	-LRB-
cord-018265-twp33bb6	297	4	CF	CF	NNP
cord-018265-twp33bb6	297	5	)	)	-RRB-
cord-018265-twp33bb6	297	6	patients	patient	NNS
cord-018265-twp33bb6	297	7	are	be	VBP
cord-018265-twp33bb6	297	8	particularly	particularly	RB
cord-018265-twp33bb6	297	9	susceptible	susceptible	JJ
cord-018265-twp33bb6	297	10	to	to	IN
cord-018265-twp33bb6	297	11	severe	severe	JJ
cord-018265-twp33bb6	297	12	bacterial	bacterial	JJ
cord-018265-twp33bb6	297	13	infections	infection	NNS
cord-018265-twp33bb6	297	14	of	of	IN
cord-018265-twp33bb6	297	15	the	the	DT
cord-018265-twp33bb6	297	16	lung	lung	NN
cord-018265-twp33bb6	297	17	,	,	,
cord-018265-twp33bb6	297	18	being	be	VBG
cord-018265-twp33bb6	297	19	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	297	20	aeruginosa	aeruginosa	IN
cord-018265-twp33bb6	297	21	one	one	CD
cord-018265-twp33bb6	297	22	of	of	IN
cord-018265-twp33bb6	297	23	the	the	DT
cord-018265-twp33bb6	297	24	most	most	RBS
cord-018265-twp33bb6	297	25	prominent	prominent	JJ
cord-018265-twp33bb6	297	26	etiologic	etiologic	JJ
cord-018265-twp33bb6	297	27	agents	agent	NNS
cord-018265-twp33bb6	297	28	.	.	.
cord-018265-twp33bb6	298	1	Thus	thus	RB
cord-018265-twp33bb6	298	2	,	,	,
cord-018265-twp33bb6	298	3	significant	significant	JJ
cord-018265-twp33bb6	298	4	efforts	effort	NNS
cord-018265-twp33bb6	298	5	have	have	VBP
cord-018265-twp33bb6	298	6	been	be	VBN
cord-018265-twp33bb6	298	7	invested	invest	VBN
cord-018265-twp33bb6	298	8	to	to	TO
cord-018265-twp33bb6	298	9	develop	develop	VB
cord-018265-twp33bb6	298	10	a	a	DT
cord-018265-twp33bb6	298	11	vaccine	vaccine	NN
cord-018265-twp33bb6	298	12	against	against	IN
cord-018265-twp33bb6	298	13	this	this	DT
cord-018265-twp33bb6	298	14	pathogen	pathogen	NN
cord-018265-twp33bb6	298	15	.	.	.
cord-018265-twp33bb6	299	1	Surface	surface	NN
cord-018265-twp33bb6	299	2	PS	PS	NNP
cord-018265-twp33bb6	299	3	are	be	VBP
cord-018265-twp33bb6	299	4	among	among	IN
cord-018265-twp33bb6	299	5	the	the	DT
cord-018265-twp33bb6	299	6	antigens	antigen	NNS
cord-018265-twp33bb6	299	7	that	that	WDT
cord-018265-twp33bb6	299	8	were	be	VBD
cord-018265-twp33bb6	299	9	most	most	RBS
cord-018265-twp33bb6	299	10	intensively	intensively	RB
cord-018265-twp33bb6	299	11	assessed	assess	VBN
cord-018265-twp33bb6	299	12	.	.	.
cord-018265-twp33bb6	300	1	Berna	Berna	NNP
cord-018265-twp33bb6	300	2	Biotech	Biotech	NNP
cord-018265-twp33bb6	300	3	have	have	VBP
cord-018265-twp33bb6	300	4	developed	develop	VBN
cord-018265-twp33bb6	300	5	an	an	DT
cord-018265-twp33bb6	300	6	octavalent	octavalent	JJ
cord-018265-twp33bb6	300	7	vaccine	vaccine	NN
cord-018265-twp33bb6	300	8	against	against	IN
cord-018265-twp33bb6	300	9	the	the	DT
cord-018265-twp33bb6	300	10	eight	eight	CD
cord-018265-twp33bb6	300	11	most	most	RBS
cord-018265-twp33bb6	300	12	prevalent	prevalent	JJ
cord-018265-twp33bb6	300	13	serotypes	serotype	NNS
cord-018265-twp33bb6	300	14	based	base	VBN
cord-018265-twp33bb6	300	15	on	on	IN
cord-018265-twp33bb6	300	16	O	O	NNP
cord-018265-twp33bb6	300	17	-	-	HYPH
cord-018265-twp33bb6	300	18	PS	PS	NNP
cord-018265-twp33bb6	300	19	conjugated	conjugate	VBN
cord-018265-twp33bb6	300	20	with	with	IN
cord-018265-twp33bb6	300	21	the	the	DT
cord-018265-twp33bb6	300	22	exotoxin	exotoxin	NN
cord-018265-twp33bb6	301	1	A	a	DT
cord-018265-twp33bb6	301	2	[	[	-LRB-
cord-018265-twp33bb6	301	3	106	106	CD
cord-018265-twp33bb6	301	4	]	]	-RRB-
cord-018265-twp33bb6	302	1	[	[	-LRB-
cord-018265-twp33bb6	302	2	107	107	CD
cord-018265-twp33bb6	302	3	]	]	-RRB-
cord-018265-twp33bb6	303	1	[	[	-LRB-
cord-018265-twp33bb6	303	2	108	108	CD
cord-018265-twp33bb6	303	3	]	]	-RRB-
cord-018265-twp33bb6	303	4	[	[	-LRB-
cord-018265-twp33bb6	303	5	109	109	CD
cord-018265-twp33bb6	303	6	]	]	-RRB-
cord-018265-twp33bb6	303	7	[	[	-LRB-
cord-018265-twp33bb6	303	8	110	110	CD
cord-018265-twp33bb6	303	9	]	]	-RRB-
cord-018265-twp33bb6	303	10	[	[	-LRB-
cord-018265-twp33bb6	303	11	111	111	CD
cord-018265-twp33bb6	303	12	]	]	-RRB-
cord-018265-twp33bb6	303	13	[	[	-LRB-
cord-018265-twp33bb6	303	14	112	112	CD
cord-018265-twp33bb6	303	15	]	]	-RRB-
cord-018265-twp33bb6	303	16	[	[	-LRB-
cord-018265-twp33bb6	303	17	113	113	CD
cord-018265-twp33bb6	303	18	]	]	-RRB-
cord-018265-twp33bb6	303	19	.	.	.
cord-018265-twp33bb6	304	1	A	a	DT
cord-018265-twp33bb6	304	2	consistent	consistent	JJ
cord-018265-twp33bb6	304	3	reduction	reduction	NN
cord-018265-twp33bb6	304	4	in	in	IN
cord-018265-twp33bb6	304	5	the	the	DT
cord-018265-twp33bb6	304	6	number	number	NN
cord-018265-twp33bb6	304	7	of	of	IN
cord-018265-twp33bb6	304	8	CF	cf	NN
cord-018265-twp33bb6	304	9	patients	patient	NNS
cord-018265-twp33bb6	304	10	with	with	IN
cord-018265-twp33bb6	304	11	chronic	chronic	JJ
cord-018265-twp33bb6	304	12	P.	P.	NNP
cord-018265-twp33bb6	304	13	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	304	14	lung	lung	NN
cord-018265-twp33bb6	304	15	infection	infection	NN
cord-018265-twp33bb6	304	16	was	be	VBD
cord-018265-twp33bb6	304	17	observed	observe	VBN
cord-018265-twp33bb6	304	18	in	in	IN
cord-018265-twp33bb6	304	19	a	a	DT
cord-018265-twp33bb6	304	20	cohort	cohort	NN
cord-018265-twp33bb6	304	21	receiving	receive	VBG
cord-018265-twp33bb6	304	22	the	the	DT
cord-018265-twp33bb6	304	23	basic	basic	JJ
cord-018265-twp33bb6	304	24	immunization	immunization	NN
cord-018265-twp33bb6	304	25	protocol	protocol	NN
cord-018265-twp33bb6	304	26	,	,	,
cord-018265-twp33bb6	304	27	followed	follow	VBN
cord-018265-twp33bb6	304	28	by	by	IN
cord-018265-twp33bb6	304	29	yearly	yearly	JJ
cord-018265-twp33bb6	304	30	boosters	booster	NNS
cord-018265-twp33bb6	304	31	over	over	IN
cord-018265-twp33bb6	304	32	a	a	DT
cord-018265-twp33bb6	304	33	period	period	NN
cord-018265-twp33bb6	304	34	of	of	IN
cord-018265-twp33bb6	304	35	10	10	CD
cord-018265-twp33bb6	304	36	years	year	NNS
cord-018265-twp33bb6	304	37	[	[	-LRB-
cord-018265-twp33bb6	304	38	112	112	CD
cord-018265-twp33bb6	304	39	,	,	,
cord-018265-twp33bb6	304	40	113	113	CD
cord-018265-twp33bb6	304	41	]	]	-RRB-
cord-018265-twp33bb6	304	42	.	.	.
cord-018265-twp33bb6	305	1	The	the	DT
cord-018265-twp33bb6	305	2	conjugate	conjugate	JJ
cord-018265-twp33bb6	305	3	vaccine	vaccine	NN
cord-018265-twp33bb6	305	4	induced	induce	VBD
cord-018265-twp33bb6	305	5	the	the	DT
cord-018265-twp33bb6	305	6	production	production	NN
cord-018265-twp33bb6	305	7	of	of	IN
cord-018265-twp33bb6	305	8	specific	specific	JJ
cord-018265-twp33bb6	305	9	IgG	igg	NN
cord-018265-twp33bb6	305	10	antibodies	antibody	NNS
cord-018265-twp33bb6	305	11	and	and	CC
cord-018265-twp33bb6	305	12	increased	increase	VBD
cord-018265-twp33bb6	305	13	the	the	DT
cord-018265-twp33bb6	305	14	number	number	NN
cord-018265-twp33bb6	305	15	of	of	IN
cord-018265-twp33bb6	305	16	IgG	IgG	NNP
cord-018265-twp33bb6	305	17	memory	memory	NN
cord-018265-twp33bb6	305	18	B	B	NNP
cord-018265-twp33bb6	305	19	cells	cell	NNS
cord-018265-twp33bb6	305	20	.	.	.
cord-018265-twp33bb6	306	1	It	-PRON-	PRP
cord-018265-twp33bb6	306	2	is	be	VBZ
cord-018265-twp33bb6	306	3	still	still	RB
cord-018265-twp33bb6	306	4	unclear	unclear	JJ
cord-018265-twp33bb6	306	5	if	if	IN
cord-018265-twp33bb6	306	6	cellular	cellular	JJ
cord-018265-twp33bb6	306	7	responses	response	NNS
cord-018265-twp33bb6	306	8	might	may	MD
cord-018265-twp33bb6	306	9	contribute	contribute	VB
cord-018265-twp33bb6	306	10	to	to	IN
cord-018265-twp33bb6	306	11	the	the	DT
cord-018265-twp33bb6	306	12	overall	overall	JJ
cord-018265-twp33bb6	306	13	protection	protection	NN
cord-018265-twp33bb6	306	14	conferred	confer	VBN
cord-018265-twp33bb6	306	15	by	by	IN
cord-018265-twp33bb6	306	16	this	this	DT
cord-018265-twp33bb6	306	17	vaccine	vaccine	NN
cord-018265-twp33bb6	306	18	.	.	.
cord-018265-twp33bb6	307	1	However	however	RB
cord-018265-twp33bb6	307	2	,	,	,
cord-018265-twp33bb6	307	3	strong	strong	JJ
cord-018265-twp33bb6	307	4	proliferative	proliferative	JJ
cord-018265-twp33bb6	307	5	responses	response	NNS
cord-018265-twp33bb6	307	6	of	of	IN
cord-018265-twp33bb6	307	7	lymphocytes	lymphocyte	NNS
cord-018265-twp33bb6	307	8	with	with	IN
cord-018265-twp33bb6	307	9	a	a	DT
cord-018265-twp33bb6	307	10	Th1	th1	CD
cord-018265-twp33bb6	307	11	phenotype	phenotype	NN
cord-018265-twp33bb6	307	12	were	be	VBD
cord-018265-twp33bb6	307	13	observed	observe	VBN
cord-018265-twp33bb6	307	14	in	in	IN
cord-018265-twp33bb6	307	15	vaccinated	vaccinated	JJ
cord-018265-twp33bb6	307	16	individuals	individual	NNS
cord-018265-twp33bb6	307	17	in	in	IN
cord-018265-twp33bb6	307	18	response	response	NN
cord-018265-twp33bb6	307	19	to	to	IN
cord-018265-twp33bb6	307	20	the	the	DT
cord-018265-twp33bb6	307	21	carrier	carrier	NN
cord-018265-twp33bb6	307	22	exotoxin	exotoxin	NN
cord-018265-twp33bb6	307	23	A	a	DT
cord-018265-twp33bb6	307	24	protein	protein	NN
cord-018265-twp33bb6	307	25	[	[	-LRB-
cord-018265-twp33bb6	307	26	113	113	CD
cord-018265-twp33bb6	307	27	]	]	-RRB-
cord-018265-twp33bb6	307	28	.	.	.
cord-018265-twp33bb6	308	1	Alternative	alternative	JJ
cord-018265-twp33bb6	308	2	vaccination	vaccination	NN
cord-018265-twp33bb6	308	3	strategies	strategy	NNS
cord-018265-twp33bb6	308	4	are	be	VBP
cord-018265-twp33bb6	308	5	currently	currently	RB
cord-018265-twp33bb6	308	6	being	be	VBG
cord-018265-twp33bb6	308	7	tested	test	VBN
cord-018265-twp33bb6	308	8	in	in	IN
cord-018265-twp33bb6	308	9	clinical	clinical	JJ
cord-018265-twp33bb6	308	10	trials	trial	NNS
cord-018265-twp33bb6	308	11	.	.	.
cord-018265-twp33bb6	309	1	Among	among	IN
cord-018265-twp33bb6	309	2	them	-PRON-	PRP
cord-018265-twp33bb6	309	3	,	,	,
cord-018265-twp33bb6	309	4	formulations	formulation	NNS
cord-018265-twp33bb6	309	5	based	base	VBN
cord-018265-twp33bb6	309	6	on	on	IN
cord-018265-twp33bb6	309	7	a	a	DT
cord-018265-twp33bb6	309	8	fusion	fusion	NN
cord-018265-twp33bb6	309	9	protein	protein	NN
cord-018265-twp33bb6	309	10	between	between	IN
cord-018265-twp33bb6	309	11	the	the	DT
cord-018265-twp33bb6	309	12	outer	outer	JJ
cord-018265-twp33bb6	309	13	membrane	membrane	NN
cord-018265-twp33bb6	309	14	proteins	protein	NNS
cord-018265-twp33bb6	309	15	F	F	NNP
cord-018265-twp33bb6	309	16	and	and	CC
cord-018265-twp33bb6	309	17	I	I	NNP
cord-018265-twp33bb6	309	18	,	,	,
cord-018265-twp33bb6	309	19	which	which	WDT
cord-018265-twp33bb6	309	20	have	have	VBP
cord-018265-twp33bb6	309	21	been	be	VBN
cord-018265-twp33bb6	309	22	administered	administer	VBN
cord-018265-twp33bb6	309	23	by	by	IN
cord-018265-twp33bb6	309	24	parenteral	parenteral	JJ
cord-018265-twp33bb6	309	25	and	and	CC
cord-018265-twp33bb6	309	26	mucosal	mucosal	JJ
cord-018265-twp33bb6	309	27	routes	route	NNS
cord-018265-twp33bb6	309	28	[	[	-LRB-
cord-018265-twp33bb6	309	29	114	114	CD
cord-018265-twp33bb6	309	30	,	,	,
cord-018265-twp33bb6	309	31	115	115	CD
cord-018265-twp33bb6	309	32	]	]	-RRB-
cord-018265-twp33bb6	309	33	.	.	.
cord-018265-twp33bb6	310	1	These	these	DT
cord-018265-twp33bb6	310	2	formulations	formulation	NNS
cord-018265-twp33bb6	310	3	were	be	VBD
cord-018265-twp33bb6	310	4	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	310	5	to	to	TO
cord-018265-twp33bb6	310	6	be	be	VB
cord-018265-twp33bb6	310	7	safe	safe	JJ
cord-018265-twp33bb6	310	8	in	in	IN
cord-018265-twp33bb6	310	9	volunteers	volunteer	NNS
cord-018265-twp33bb6	310	10	and	and	CC
cord-018265-twp33bb6	310	11	conferred	confer	VBD
cord-018265-twp33bb6	310	12	increased	increased	JJ
cord-018265-twp33bb6	310	13	protection	protection	NN
cord-018265-twp33bb6	310	14	against	against	IN
cord-018265-twp33bb6	310	15	P.	P.	NNP
cord-018265-twp33bb6	310	16	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	310	17	in	in	IN
cord-018265-twp33bb6	310	18	CF	cf	NN
cord-018265-twp33bb6	310	19	patients	patient	NNS
cord-018265-twp33bb6	310	20	.	.	.
cord-018265-twp33bb6	311	1	Cell	cell	NN
cord-018265-twp33bb6	311	2	-	-	HYPH
cord-018265-twp33bb6	311	3	surface	surface	NN
cord-018265-twp33bb6	311	4	alginate	alginate	NN
cord-018265-twp33bb6	311	5	,	,	,
cord-018265-twp33bb6	311	6	flagella	flagellum	NNS
cord-018265-twp33bb6	311	7	,	,	,
cord-018265-twp33bb6	311	8	components	component	NNS
cord-018265-twp33bb6	311	9	of	of	IN
cord-018265-twp33bb6	311	10	the	the	DT
cord-018265-twp33bb6	311	11	type	type	NN
cord-018265-twp33bb6	311	12	III	iii	CD
cord-018265-twp33bb6	311	13	secretion	secretion	NN
cord-018265-twp33bb6	311	14	system	system	NN
cord-018265-twp33bb6	311	15	,	,	,
cord-018265-twp33bb6	311	16	inactivated	inactivate	VBN
cord-018265-twp33bb6	311	17	toxins	toxin	NNS
cord-018265-twp33bb6	311	18	and	and	CC
cord-018265-twp33bb6	311	19	proteases	protease	NNS
cord-018265-twp33bb6	311	20	are	be	VBP
cord-018265-twp33bb6	311	21	other	other	JJ
cord-018265-twp33bb6	311	22	proposed	propose	VBN
cord-018265-twp33bb6	311	23	target	target	NN
cord-018265-twp33bb6	311	24	antigens	antigen	NNS
cord-018265-twp33bb6	311	25	[	[	-LRB-
cord-018265-twp33bb6	311	26	116	116	CD
cord-018265-twp33bb6	311	27	]	]	-RRB-
cord-018265-twp33bb6	311	28	.	.	.
cord-018265-twp33bb6	312	1	Some	some	DT
cord-018265-twp33bb6	312	2	of	of	IN
cord-018265-twp33bb6	312	3	them	-PRON-	PRP
cord-018265-twp33bb6	312	4	are	be	VBP
cord-018265-twp33bb6	312	5	already	already	RB
cord-018265-twp33bb6	312	6	in	in	IN
cord-018265-twp33bb6	312	7	clinical	clinical	JJ
cord-018265-twp33bb6	312	8	trials	trial	NNS
cord-018265-twp33bb6	312	9	alone	alone	RB
cord-018265-twp33bb6	312	10	or	or	CC
cord-018265-twp33bb6	312	11	in	in	IN
cord-018265-twp33bb6	312	12	combination	combination	NN
cord-018265-twp33bb6	312	13	[	[	-LRB-
cord-018265-twp33bb6	312	14	116	116	CD
cord-018265-twp33bb6	312	15	]	]	-RRB-
cord-018265-twp33bb6	312	16	.	.	.
cord-018265-twp33bb6	313	1	When	when	WRB
cord-018265-twp33bb6	313	2	Pasteur	Pasteur	NNP
cord-018265-twp33bb6	313	3	returned	return	VBD
cord-018265-twp33bb6	313	4	from	from	IN
cord-018265-twp33bb6	313	5	his	-PRON-	PRP$
cord-018265-twp33bb6	313	6	summer	summer	NN
cord-018265-twp33bb6	313	7	holidays	holiday	NNS
cord-018265-twp33bb6	313	8	in	in	IN
cord-018265-twp33bb6	313	9	1881	1881	CD
cord-018265-twp33bb6	313	10	to	to	TO
cord-018265-twp33bb6	313	11	continue	continue	VB
cord-018265-twp33bb6	313	12	with	with	IN
cord-018265-twp33bb6	313	13	his	-PRON-	PRP$
cord-018265-twp33bb6	313	14	studies	study	NNS
cord-018265-twp33bb6	313	15	on	on	IN
cord-018265-twp33bb6	313	16	chicken	chicken	NN
cord-018265-twp33bb6	313	17	cholera	cholera	NN
cord-018265-twp33bb6	313	18	,	,	,
cord-018265-twp33bb6	313	19	he	-PRON-	PRP
cord-018265-twp33bb6	313	20	inoculated	inoculate	VBD
cord-018265-twp33bb6	313	21	chickens	chicken	NNS
cord-018265-twp33bb6	313	22	with	with	IN
cord-018265-twp33bb6	313	23	an	an	DT
cord-018265-twp33bb6	313	24	old	old	JJ
cord-018265-twp33bb6	313	25	culture	culture	NN
cord-018265-twp33bb6	313	26	of	of	IN
cord-018265-twp33bb6	313	27	Pasteurella	Pasteurella	NNP
cord-018265-twp33bb6	313	28	multocida	multocida	NNP
cord-018265-twp33bb6	313	29	,	,	,
cord-018265-twp33bb6	313	30	which	which	WDT
cord-018265-twp33bb6	313	31	was	be	VBD
cord-018265-twp33bb6	313	32	left	leave	VBN
cord-018265-twp33bb6	313	33	during	during	IN
cord-018265-twp33bb6	313	34	the	the	DT
cord-018265-twp33bb6	313	35	whole	whole	JJ
cord-018265-twp33bb6	313	36	summer	summer	NN
cord-018265-twp33bb6	313	37	on	on	IN
cord-018265-twp33bb6	313	38	his	-PRON-	PRP$
cord-018265-twp33bb6	313	39	bench	bench	NN
cord-018265-twp33bb6	313	40	.	.	.
cord-018265-twp33bb6	314	1	The	the	DT
cord-018265-twp33bb6	314	2	animals	animal	NNS
cord-018265-twp33bb6	314	3	that	that	WDT
cord-018265-twp33bb6	314	4	received	receive	VBD
cord-018265-twp33bb6	314	5	the	the	DT
cord-018265-twp33bb6	314	6	preparation	preparation	NN
cord-018265-twp33bb6	314	7	were	be	VBD
cord-018265-twp33bb6	314	8	protected	protect	VBN
cord-018265-twp33bb6	314	9	against	against	IN
cord-018265-twp33bb6	314	10	a	a	DT
cord-018265-twp33bb6	314	11	challenge	challenge	NN
cord-018265-twp33bb6	314	12	performed	perform	VBN
cord-018265-twp33bb6	314	13	with	with	IN
cord-018265-twp33bb6	314	14	a	a	DT
cord-018265-twp33bb6	314	15	fresh	fresh	JJ
cord-018265-twp33bb6	314	16	isolate	isolate	NN
cord-018265-twp33bb6	314	17	.	.	.
cord-018265-twp33bb6	315	1	Thus	thus	RB
cord-018265-twp33bb6	315	2	,	,	,
cord-018265-twp33bb6	315	3	Pasteur	Pasteur	NNP
cord-018265-twp33bb6	315	4	developed	develop	VBD
cord-018265-twp33bb6	315	5	the	the	DT
cord-018265-twp33bb6	315	6	hypothesis	hypothesis	NN
cord-018265-twp33bb6	315	7	that	that	IN
cord-018265-twp33bb6	315	8	pathogens	pathogen	NNS
cord-018265-twp33bb6	315	9	could	could	MD
cord-018265-twp33bb6	315	10	be	be	VB
cord-018265-twp33bb6	315	11	attenuated	attenuate	VBN
cord-018265-twp33bb6	315	12	by	by	IN
cord-018265-twp33bb6	315	13	exposure	exposure	NN
cord-018265-twp33bb6	315	14	to	to	IN
cord-018265-twp33bb6	315	15	environmental	environmental	JJ
cord-018265-twp33bb6	315	16	insults	insult	NNS
cord-018265-twp33bb6	315	17	(	(	-LRB-
cord-018265-twp33bb6	315	18	e.g.	e.g.	RB
cord-018265-twp33bb6	315	19	,	,	,
cord-018265-twp33bb6	315	20	high	high	JJ
cord-018265-twp33bb6	315	21	temperature	temperature	NN
cord-018265-twp33bb6	315	22	,	,	,
cord-018265-twp33bb6	315	23	oxygen	oxygen	NN
cord-018265-twp33bb6	315	24	and	and	CC
cord-018265-twp33bb6	315	25	chemicals	chemical	NNS
cord-018265-twp33bb6	315	26	)	)	-RRB-
cord-018265-twp33bb6	315	27	[	[	-LRB-
cord-018265-twp33bb6	315	28	117	117	CD
cord-018265-twp33bb6	315	29	]	]	-RRB-
cord-018265-twp33bb6	315	30	.	.	.
cord-018265-twp33bb6	316	1	The	the	DT
cord-018265-twp33bb6	316	2	strategy	strategy	NN
cord-018265-twp33bb6	316	3	was	be	VBD
cord-018265-twp33bb6	316	4	then	then	RB
cord-018265-twp33bb6	316	5	successfully	successfully	RB
cord-018265-twp33bb6	316	6	extrapolated	extrapolate	VBN
cord-018265-twp33bb6	316	7	for	for	IN
cord-018265-twp33bb6	316	8	developing	develop	VBG
cord-018265-twp33bb6	316	9	anthrax	anthrax	NN
cord-018265-twp33bb6	316	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	316	11	in	in	IN
cord-018265-twp33bb6	316	12	livestock	livestock	NN
cord-018265-twp33bb6	316	13	in	in	IN
cord-018265-twp33bb6	316	14	the	the	DT
cord-018265-twp33bb6	316	15	1880s	1880	NNS
cord-018265-twp33bb6	316	16	,	,	,
cord-018265-twp33bb6	316	17	with	with	IN
cord-018265-twp33bb6	316	18	significant	significant	JJ
cord-018265-twp33bb6	316	19	economic	economic	JJ
cord-018265-twp33bb6	316	20	benefits	benefit	NNS
cord-018265-twp33bb6	316	21	.	.	.
cord-018265-twp33bb6	317	1	This	this	DT
cord-018265-twp33bb6	317	2	was	be	VBD
cord-018265-twp33bb6	317	3	followed	follow	VBN
cord-018265-twp33bb6	317	4	by	by	IN
cord-018265-twp33bb6	317	5	the	the	DT
cord-018265-twp33bb6	317	6	generation	generation	NN
cord-018265-twp33bb6	317	7	of	of	IN
cord-018265-twp33bb6	317	8	attenuated	attenuated	JJ
cord-018265-twp33bb6	317	9	vaccines	vaccine	NNS
cord-018265-twp33bb6	317	10	against	against	IN
cord-018265-twp33bb6	317	11	rabies	rabie	NNS
cord-018265-twp33bb6	317	12	and	and	CC
cord-018265-twp33bb6	317	13	other	other	JJ
cord-018265-twp33bb6	317	14	important	important	JJ
cord-018265-twp33bb6	317	15	pathogens	pathogen	NNS
cord-018265-twp33bb6	317	16	towards	towards	IN
cord-018265-twp33bb6	317	17	the	the	DT
cord-018265-twp33bb6	317	18	end	end	NN
cord-018265-twp33bb6	317	19	of	of	IN
cord-018265-twp33bb6	317	20	the	the	DT
cord-018265-twp33bb6	317	21	nineteenth	nineteenth	JJ
cord-018265-twp33bb6	317	22	century	century	NN
cord-018265-twp33bb6	317	23	.	.	.
cord-018265-twp33bb6	318	1	Pasteur	Pasteur	NNP
cord-018265-twp33bb6	318	2	's	's	POS
cord-018265-twp33bb6	318	3	approach	approach	NN
cord-018265-twp33bb6	318	4	for	for	IN
cord-018265-twp33bb6	318	5	"	"	``
cord-018265-twp33bb6	318	6	attenuating	attenuate	VBG
cord-018265-twp33bb6	318	7	"	"	''
cord-018265-twp33bb6	318	8	or	or	CC
cord-018265-twp33bb6	318	9	"	"	``
cord-018265-twp33bb6	318	10	inactivating	inactivate	VBG
cord-018265-twp33bb6	318	11	"	"	''
cord-018265-twp33bb6	318	12	a	a	DT
cord-018265-twp33bb6	318	13	pathogenic	pathogenic	JJ
cord-018265-twp33bb6	318	14	organisms	organism	NNS
cord-018265-twp33bb6	318	15	still	still	RB
cord-018265-twp33bb6	318	16	constitutes	constitute	VBZ
cord-018265-twp33bb6	318	17	a	a	DT
cord-018265-twp33bb6	318	18	cornerstone	cornerstone	NN
cord-018265-twp33bb6	318	19	in	in	IN
cord-018265-twp33bb6	318	20	vaccine	vaccine	NN
cord-018265-twp33bb6	318	21	technology	technology	NN
cord-018265-twp33bb6	318	22	[	[	-LRB-
cord-018265-twp33bb6	318	23	117	117	CD
cord-018265-twp33bb6	318	24	]	]	-RRB-
cord-018265-twp33bb6	318	25	.	.	.
cord-018265-twp33bb6	319	1	This	this	DT
cord-018265-twp33bb6	319	2	exemplifies	exemplify	VBZ
cord-018265-twp33bb6	319	3	that	that	IN
cord-018265-twp33bb6	319	4	until	until	IN
cord-018265-twp33bb6	319	5	recently	recently	RB
cord-018265-twp33bb6	319	6	the	the	DT
cord-018265-twp33bb6	319	7	major	major	JJ
cord-018265-twp33bb6	319	8	achievements	achievement	NNS
cord-018265-twp33bb6	319	9	in	in	IN
cord-018265-twp33bb6	319	10	vaccinology	vaccinology	NN
cord-018265-twp33bb6	319	11	have	have	VBP
cord-018265-twp33bb6	319	12	been	be	VBN
cord-018265-twp33bb6	319	13	facilitated	facilitate	VBN
cord-018265-twp33bb6	319	14	by	by	IN
cord-018265-twp33bb6	319	15	technological	technological	JJ
cord-018265-twp33bb6	319	16	(	(	-LRB-
cord-018265-twp33bb6	319	17	e.g.	e.g.	RB
cord-018265-twp33bb6	319	18	,	,	,
cord-018265-twp33bb6	319	19	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	319	20	,	,	,
cord-018265-twp33bb6	319	21	delivery	delivery	NN
cord-018265-twp33bb6	319	22	systems	system	NNS
cord-018265-twp33bb6	319	23	,	,	,
cord-018265-twp33bb6	319	24	reverse	reverse	VB
cord-018265-twp33bb6	319	25	vaccinology	vaccinology	NN
cord-018265-twp33bb6	319	26	,	,	,
cord-018265-twp33bb6	319	27	genetic	genetic	JJ
cord-018265-twp33bb6	319	28	engineering	engineering	NN
cord-018265-twp33bb6	319	29	)	)	-RRB-
cord-018265-twp33bb6	319	30	rather	rather	RB
cord-018265-twp33bb6	319	31	than	than	IN
cord-018265-twp33bb6	319	32	immunological	immunological	JJ
cord-018265-twp33bb6	319	33	advances	advance	NNS
cord-018265-twp33bb6	319	34	[	[	-LRB-
cord-018265-twp33bb6	319	35	117	117	CD
cord-018265-twp33bb6	319	36	]	]	-RRB-
cord-018265-twp33bb6	319	37	[	[	-LRB-
cord-018265-twp33bb6	319	38	118	118	CD
cord-018265-twp33bb6	319	39	]	]	-RRB-
cord-018265-twp33bb6	319	40	[	[	-LRB-
cord-018265-twp33bb6	319	41	119	119	CD
cord-018265-twp33bb6	319	42	]	]	-RRB-
cord-018265-twp33bb6	319	43	.	.	.
cord-018265-twp33bb6	320	1	However	however	RB
cord-018265-twp33bb6	320	2	,	,	,
cord-018265-twp33bb6	320	3	it	-PRON-	PRP
cord-018265-twp33bb6	320	4	is	be	VBZ
cord-018265-twp33bb6	320	5	expected	expect	VBN
cord-018265-twp33bb6	320	6	that	that	IN
cord-018265-twp33bb6	320	7	the	the	DT
cord-018265-twp33bb6	320	8	impressive	impressive	JJ
cord-018265-twp33bb6	320	9	knowledge	knowledge	NN
cord-018265-twp33bb6	320	10	accumulated	accumulate	VBN
cord-018265-twp33bb6	320	11	in	in	IN
cord-018265-twp33bb6	320	12	recent	recent	JJ
cord-018265-twp33bb6	320	13	years	year	NNS
cord-018265-twp33bb6	320	14	in	in	IN
cord-018265-twp33bb6	320	15	the	the	DT
cord-018265-twp33bb6	320	16	fields	field	NNS
cord-018265-twp33bb6	320	17	of	of	IN
cord-018265-twp33bb6	320	18	immunology	immunology	NN
cord-018265-twp33bb6	320	19	,	,	,
cord-018265-twp33bb6	320	20	immune	immune	JJ
cord-018265-twp33bb6	320	21	pathology	pathology	NN
cord-018265-twp33bb6	320	22	and	and	CC
cord-018265-twp33bb6	320	23	microbial	microbial	JJ
cord-018265-twp33bb6	320	24	pathogenesis	pathogenesis	NN
cord-018265-twp33bb6	320	25	will	will	MD
cord-018265-twp33bb6	320	26	pave	pave	VB
cord-018265-twp33bb6	320	27	the	the	DT
cord-018265-twp33bb6	320	28	road	road	NN
cord-018265-twp33bb6	320	29	to	to	IN
cord-018265-twp33bb6	320	30	a	a	DT
cord-018265-twp33bb6	320	31	new	new	JJ
cord-018265-twp33bb6	320	32	golden	golden	JJ
cord-018265-twp33bb6	320	33	era	era	NN
cord-018265-twp33bb6	320	34	in	in	IN
cord-018265-twp33bb6	320	35	vaccinology	vaccinology	NN
cord-018265-twp33bb6	320	36	,	,	,
cord-018265-twp33bb6	320	37	in	in	IN
cord-018265-twp33bb6	320	38	which	which	WDT
cord-018265-twp33bb6	320	39	knowledge	knowledge	NN
cord-018265-twp33bb6	320	40	and	and	CC
cord-018265-twp33bb6	320	41	technology	technology	NN
cord-018265-twp33bb6	320	42	will	will	MD
cord-018265-twp33bb6	320	43	enable	enable	VB
cord-018265-twp33bb6	320	44	rational	rational	JJ
cord-018265-twp33bb6	320	45	vaccine	vaccine	NN
cord-018265-twp33bb6	320	46	design	design	NN
cord-018265-twp33bb6	320	47	.	.	.
cord-018265-twp33bb6	321	1	In	in	IN
cord-018265-twp33bb6	321	2	the	the	DT
cord-018265-twp33bb6	321	3	20th	20th	JJ
cord-018265-twp33bb6	321	4	century	century	NN
cord-018265-twp33bb6	321	5	,	,	,
cord-018265-twp33bb6	321	6	pertussis	pertussis	NN
cord-018265-twp33bb6	321	7	vaccines	vaccine	NNS
cord-018265-twp33bb6	321	8	progressed	progress	VBD
cord-018265-twp33bb6	321	9	from	from	IN
cord-018265-twp33bb6	321	10	crude	crude	JJ
cord-018265-twp33bb6	321	11	bacterial	bacterial	JJ
cord-018265-twp33bb6	321	12	preparations	preparation	NNS
cord-018265-twp33bb6	321	13	to	to	IN
cord-018265-twp33bb6	321	14	the	the	DT
cord-018265-twp33bb6	321	15	highly	highly	RB
cord-018265-twp33bb6	321	16	purified	purify	VBN
cord-018265-twp33bb6	321	17	antigens	antigen	NNS
cord-018265-twp33bb6	321	18	used	use	VBN
cord-018265-twp33bb6	321	19	for	for	IN
cord-018265-twp33bb6	321	20	acellular	acellular	JJ
cord-018265-twp33bb6	321	21	vaccines	vaccine	NNS
cord-018265-twp33bb6	321	22	.	.	.
cord-018265-twp33bb6	322	1	A	a	DT
cord-018265-twp33bb6	322	2	similar	similar	JJ
cord-018265-twp33bb6	322	3	quantum	quantum	NN
cord-018265-twp33bb6	322	4	jump	jump	NN
cord-018265-twp33bb6	322	5	in	in	IN
cord-018265-twp33bb6	322	6	technology	technology	NN
cord-018265-twp33bb6	322	7	allowed	allow	VBD
cord-018265-twp33bb6	322	8	the	the	DT
cord-018265-twp33bb6	322	9	development	development	NN
cord-018265-twp33bb6	322	10	of	of	IN
cord-018265-twp33bb6	322	11	subunit	subunit	NN
cord-018265-twp33bb6	322	12	vaccines	vaccine	NNS
cord-018265-twp33bb6	322	13	against	against	IN
cord-018265-twp33bb6	322	14	influenza	influenza	NN
cord-018265-twp33bb6	322	15	,	,	,
cord-018265-twp33bb6	322	16	Hib	Hib	NNP
cord-018265-twp33bb6	322	17	and	and	CC
cord-018265-twp33bb6	322	18	S.	S.	NNP
cord-018265-twp33bb6	322	19	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	322	20	,	,	,
cord-018265-twp33bb6	322	21	as	as	RB
cord-018265-twp33bb6	322	22	well	well	RB
cord-018265-twp33bb6	322	23	as	as	IN
cord-018265-twp33bb6	322	24	the	the	DT
cord-018265-twp33bb6	322	25	production	production	NN
cord-018265-twp33bb6	322	26	of	of	IN
cord-018265-twp33bb6	322	27	antigens	antigen	NNS
cord-018265-twp33bb6	322	28	by	by	IN
cord-018265-twp33bb6	322	29	recombinant	recombinant	JJ
cord-018265-twp33bb6	322	30	DNA	dna	NN
cord-018265-twp33bb6	322	31	techniques	technique	NNS
cord-018265-twp33bb6	322	32	(	(	-LRB-
cord-018265-twp33bb6	322	33	e.g.	e.g.	RB
cord-018265-twp33bb6	322	34	,	,	,
cord-018265-twp33bb6	322	35	genetically	genetically	RB
cord-018265-twp33bb6	322	36	inactivated	inactivate	VBN
cord-018265-twp33bb6	322	37	PT	pt	NN
cord-018265-twp33bb6	322	38	)	)	-RRB-
cord-018265-twp33bb6	322	39	.	.	.
cord-018265-twp33bb6	323	1	Despite	despite	IN
cord-018265-twp33bb6	323	2	the	the	DT
cord-018265-twp33bb6	323	3	fact	fact	NN
cord-018265-twp33bb6	323	4	that	that	IN
cord-018265-twp33bb6	323	5	these	these	DT
cord-018265-twp33bb6	323	6	techniques	technique	NNS
cord-018265-twp33bb6	323	7	enable	enable	VBP
cord-018265-twp33bb6	323	8	the	the	DT
cord-018265-twp33bb6	323	9	production	production	NN
cord-018265-twp33bb6	323	10	of	of	IN
cord-018265-twp33bb6	323	11	almost	almost	RB
cord-018265-twp33bb6	323	12	any	any	DT
cord-018265-twp33bb6	323	13	foreseeable	foreseeable	JJ
cord-018265-twp33bb6	323	14	antigen	antigen	NN
cord-018265-twp33bb6	323	15	,	,	,
cord-018265-twp33bb6	323	16	the	the	DT
cord-018265-twp33bb6	323	17	identification	identification	NN
cord-018265-twp33bb6	323	18	of	of	IN
cord-018265-twp33bb6	323	19	suitable	suitable	JJ
cord-018265-twp33bb6	323	20	targets	target	NNS
cord-018265-twp33bb6	323	21	still	still	RB
cord-018265-twp33bb6	323	22	remained	remain	VBD
cord-018265-twp33bb6	323	23	as	as	IN
cord-018265-twp33bb6	323	24	a	a	DT
cord-018265-twp33bb6	323	25	main	main	JJ
cord-018265-twp33bb6	323	26	bottleneck	bottleneck	NN
cord-018265-twp33bb6	323	27	for	for	IN
cord-018265-twp33bb6	323	28	vaccine	vaccine	NN
cord-018265-twp33bb6	323	29	development	development	NN
cord-018265-twp33bb6	323	30	[	[	-LRB-
cord-018265-twp33bb6	323	31	120	120	CD
cord-018265-twp33bb6	323	32	]	]	-RRB-
cord-018265-twp33bb6	323	33	.	.	.
cord-018265-twp33bb6	324	1	The	the	DT
cord-018265-twp33bb6	324	2	advent	advent	NN
cord-018265-twp33bb6	324	3	of	of	IN
cord-018265-twp33bb6	324	4	genomics	genomic	NNS
cord-018265-twp33bb6	324	5	and	and	CC
cord-018265-twp33bb6	324	6	its	-PRON-	PRP$
cord-018265-twp33bb6	324	7	exploitation	exploitation	NN
cord-018265-twp33bb6	324	8	in	in	IN
cord-018265-twp33bb6	324	9	the	the	DT
cord-018265-twp33bb6	324	10	vaccinology	vaccinology	NN
cord-018265-twp33bb6	324	11	field	field	NN
cord-018265-twp33bb6	324	12	have	have	VBP
cord-018265-twp33bb6	324	13	rendered	render	VBN
cord-018265-twp33bb6	324	14	possible	possible	JJ
cord-018265-twp33bb6	324	15	the	the	DT
cord-018265-twp33bb6	324	16	implementation	implementation	NN
cord-018265-twp33bb6	324	17	of	of	IN
cord-018265-twp33bb6	324	18	a	a	DT
cord-018265-twp33bb6	324	19	systematic	systematic	JJ
cord-018265-twp33bb6	324	20	and	and	CC
cord-018265-twp33bb6	324	21	holistic	holistic	JJ
cord-018265-twp33bb6	324	22	approach	approach	NN
cord-018265-twp33bb6	324	23	for	for	IN
cord-018265-twp33bb6	324	24	the	the	DT
cord-018265-twp33bb6	324	25	screening	screening	NN
cord-018265-twp33bb6	324	26	,	,	,
cord-018265-twp33bb6	324	27	identification	identification	NN
cord-018265-twp33bb6	324	28	and	and	CC
cord-018265-twp33bb6	324	29	prioritisation	prioritisation	NN
cord-018265-twp33bb6	324	30	of	of	IN
cord-018265-twp33bb6	324	31	candidate	candidate	NN
cord-018265-twp33bb6	324	32	antigens	antigen	NNS
cord-018265-twp33bb6	324	33	.	.	.
cord-018265-twp33bb6	325	1	This	this	DT
cord-018265-twp33bb6	325	2	new	new	JJ
cord-018265-twp33bb6	325	3	approach	approach	NN
cord-018265-twp33bb6	325	4	,	,	,
cord-018265-twp33bb6	325	5	called	call	VBN
cord-018265-twp33bb6	325	6	"	"	``
cord-018265-twp33bb6	325	7	reverse	reverse	JJ
cord-018265-twp33bb6	325	8	vaccinology	vaccinology	NN
cord-018265-twp33bb6	325	9	"	"	''
cord-018265-twp33bb6	325	10	[	[	-LRB-
cord-018265-twp33bb6	325	11	121	121	CD
cord-018265-twp33bb6	325	12	]	]	-RRB-
cord-018265-twp33bb6	325	13	,	,	,
cord-018265-twp33bb6	325	14	does	do	VBZ
cord-018265-twp33bb6	325	15	not	not	RB
cord-018265-twp33bb6	325	16	require	require	VB
cord-018265-twp33bb6	325	17	cultivation	cultivation	NN
cord-018265-twp33bb6	325	18	of	of	IN
cord-018265-twp33bb6	325	19	the	the	DT
cord-018265-twp33bb6	325	20	original	original	JJ
cord-018265-twp33bb6	325	21	pathogen	pathogen	NN
cord-018265-twp33bb6	325	22	,	,	,
cord-018265-twp33bb6	325	23	thereby	thereby	RB
cord-018265-twp33bb6	325	24	being	be	VBG
cord-018265-twp33bb6	325	25	amenable	amenable	JJ
cord-018265-twp33bb6	325	26	for	for	IN
cord-018265-twp33bb6	325	27	highlypathogenic	highlypathogenic	JJ
cord-018265-twp33bb6	325	28	or	or	CC
cord-018265-twp33bb6	325	29	non	non	AFX
cord-018265-twp33bb6	325	30	culturable	culturable	JJ
cord-018265-twp33bb6	325	31	micro	micro	NNS
cord-018265-twp33bb6	325	32	-	-	HYPH
cord-018265-twp33bb6	325	33	organisms	organism	NNS
cord-018265-twp33bb6	325	34	.	.	.
cord-018265-twp33bb6	326	1	It	-PRON-	PRP
cord-018265-twp33bb6	326	2	is	be	VBZ
cord-018265-twp33bb6	326	3	possible	possible	JJ
cord-018265-twp33bb6	326	4	to	to	TO
cord-018265-twp33bb6	326	5	predict	predict	VB
cord-018265-twp33bb6	326	6	and	and	CC
cord-018265-twp33bb6	326	7	select	select	VB
cord-018265-twp33bb6	326	8	the	the	DT
cord-018265-twp33bb6	326	9	most	most	RBS
cord-018265-twp33bb6	326	10	promising	promising	JJ
cord-018265-twp33bb6	326	11	candidates	candidate	NNS
cord-018265-twp33bb6	326	12	by	by	IN
cord-018265-twp33bb6	326	13	the	the	DT
cord-018265-twp33bb6	326	14	analysis	analysis	NN
cord-018265-twp33bb6	326	15	of	of	IN
cord-018265-twp33bb6	326	16	genomic	genomic	JJ
cord-018265-twp33bb6	326	17	sequences	sequence	NNS
cord-018265-twp33bb6	326	18	in	in	IN
cord-018265-twp33bb6	326	19	silico	silico	NN
cord-018265-twp33bb6	326	20	,	,	,
cord-018265-twp33bb6	326	21	which	which	WDT
cord-018265-twp33bb6	326	22	will	will	MD
cord-018265-twp33bb6	326	23	then	then	RB
cord-018265-twp33bb6	326	24	be	be	VB
cord-018265-twp33bb6	326	25	cloned	clone	VBN
cord-018265-twp33bb6	326	26	and	and	CC
cord-018265-twp33bb6	326	27	expressed	express	VBN
cord-018265-twp33bb6	326	28	in	in	IN
cord-018265-twp33bb6	326	29	heterologous	heterologous	NNP
cord-018265-twp33bb6	326	30	systems	system	NNS
cord-018265-twp33bb6	326	31	.	.	.
cord-018265-twp33bb6	327	1	The	the	DT
cord-018265-twp33bb6	327	2	resulting	result	VBG
cord-018265-twp33bb6	327	3	proteins	protein	NNS
cord-018265-twp33bb6	327	4	are	be	VBP
cord-018265-twp33bb6	327	5	then	then	RB
cord-018265-twp33bb6	327	6	used	use	VBN
cord-018265-twp33bb6	327	7	to	to	TO
cord-018265-twp33bb6	327	8	perform	perform	VB
cord-018265-twp33bb6	327	9	immunological	immunological	JJ
cord-018265-twp33bb6	327	10	and/or	and/or	CC
cord-018265-twp33bb6	327	11	functional	functional	JJ
cord-018265-twp33bb6	327	12	studies	study	NNS
cord-018265-twp33bb6	327	13	to	to	TO
cord-018265-twp33bb6	327	14	select	select	VB
cord-018265-twp33bb6	327	15	the	the	DT
cord-018265-twp33bb6	327	16	most	most	RBS
cord-018265-twp33bb6	327	17	promising	promising	JJ
cord-018265-twp33bb6	327	18	candidates	candidate	NNS
cord-018265-twp33bb6	327	19	(	(	-LRB-
cord-018265-twp33bb6	327	20	e.g.	e.g.	RB
cord-018265-twp33bb6	327	21	,	,	,
cord-018265-twp33bb6	327	22	able	able	JJ
cord-018265-twp33bb6	327	23	to	to	TO
cord-018265-twp33bb6	327	24	induce	induce	VB
cord-018265-twp33bb6	327	25	the	the	DT
cord-018265-twp33bb6	327	26	production	production	NN
cord-018265-twp33bb6	327	27	of	of	IN
cord-018265-twp33bb6	327	28	microbicidal	microbicidal	NN
cord-018265-twp33bb6	327	29	or	or	CC
cord-018265-twp33bb6	327	30	neutralizing	neutralize	VBG
cord-018265-twp33bb6	327	31	antibodies	antibody	NNS
cord-018265-twp33bb6	327	32	,	,	,
cord-018265-twp33bb6	327	33	capacity	capacity	NN
cord-018265-twp33bb6	327	34	to	to	TO
cord-018265-twp33bb6	327	35	confer	confer	VB
cord-018265-twp33bb6	327	36	protective	protective	JJ
cord-018265-twp33bb6	327	37	immunity	immunity	NN
cord-018265-twp33bb6	327	38	)	)	-RRB-
cord-018265-twp33bb6	327	39	.	.	.
cord-018265-twp33bb6	328	1	Flanking	flanking	JJ
cord-018265-twp33bb6	328	2	studies	study	NNS
cord-018265-twp33bb6	328	3	are	be	VBP
cord-018265-twp33bb6	328	4	usually	usually	RB
cord-018265-twp33bb6	328	5	carried	carry	VBN
cord-018265-twp33bb6	328	6	out	out	RP
cord-018265-twp33bb6	328	7	,	,	,
cord-018265-twp33bb6	328	8	such	such	JJ
cord-018265-twp33bb6	328	9	as	as	IN
cord-018265-twp33bb6	328	10	molecular	molecular	JJ
cord-018265-twp33bb6	328	11	epidemiological	epidemiological	JJ
cord-018265-twp33bb6	328	12	analysis	analysis	NN
cord-018265-twp33bb6	328	13	to	to	TO
cord-018265-twp33bb6	328	14	assess	assess	VB
cord-018265-twp33bb6	328	15	their	-PRON-	PRP$
cord-018265-twp33bb6	328	16	degree	degree	NN
cord-018265-twp33bb6	328	17	of	of	IN
cord-018265-twp33bb6	328	18	conservation	conservation	NN
cord-018265-twp33bb6	328	19	among	among	IN
cord-018265-twp33bb6	328	20	circulating	circulate	VBG
cord-018265-twp33bb6	328	21	strains	strain	NNS
cord-018265-twp33bb6	328	22	,	,	,
cord-018265-twp33bb6	328	23	or	or	CC
cord-018265-twp33bb6	328	24	transcriptional	transcriptional	JJ
cord-018265-twp33bb6	328	25	profiling	profiling	NN
cord-018265-twp33bb6	328	26	to	to	TO
cord-018265-twp33bb6	328	27	evaluate	evaluate	VB
cord-018265-twp33bb6	328	28	their	-PRON-	PRP$
cord-018265-twp33bb6	328	29	expression	expression	NN
cord-018265-twp33bb6	328	30	during	during	IN
cord-018265-twp33bb6	328	31	natural	natural	JJ
cord-018265-twp33bb6	328	32	infections	infection	NNS
cord-018265-twp33bb6	328	33	[	[	-LRB-
cord-018265-twp33bb6	328	34	122	122	CD
cord-018265-twp33bb6	328	35	]	]	-RRB-
cord-018265-twp33bb6	328	36	.	.	.
cord-018265-twp33bb6	329	1	The	the	DT
cord-018265-twp33bb6	329	2	time	time	NN
cord-018265-twp33bb6	329	3	-	-	HYPH
cord-018265-twp33bb6	329	4	consuming	consume	VBG
cord-018265-twp33bb6	329	5	process	process	NN
cord-018265-twp33bb6	329	6	in	in	IN
cord-018265-twp33bb6	329	7	which	which	WDT
cord-018265-twp33bb6	329	8	highly	highly	RB
cord-018265-twp33bb6	329	9	expressed	express	VBD
cord-018265-twp33bb6	329	10	components	component	NNS
cord-018265-twp33bb6	329	11	of	of	IN
cord-018265-twp33bb6	329	12	an	an	DT
cord-018265-twp33bb6	329	13	in	in	FW
cord-018265-twp33bb6	329	14	vitro	vitro	FW
cord-018265-twp33bb6	329	15	cultivable	cultivable	JJ
cord-018265-twp33bb6	329	16	organism	organism	NN
cord-018265-twp33bb6	329	17	are	be	VBP
cord-018265-twp33bb6	329	18	identified	identify	VBN
cord-018265-twp33bb6	329	19	(	(	-LRB-
cord-018265-twp33bb6	329	20	one	one	CD
cord-018265-twp33bb6	329	21	at	at	IN
cord-018265-twp33bb6	329	22	a	a	DT
cord-018265-twp33bb6	329	23	time	time	NN
cord-018265-twp33bb6	329	24	)	)	-RRB-
cord-018265-twp33bb6	329	25	and	and	CC
cord-018265-twp33bb6	329	26	separated	separate	VBD
cord-018265-twp33bb6	329	27	(	(	-LRB-
cord-018265-twp33bb6	329	28	different	different	JJ
cord-018265-twp33bb6	329	29	components	component	NNS
cord-018265-twp33bb6	329	30	between	between	IN
cord-018265-twp33bb6	329	31	them	-PRON-	PRP
cord-018265-twp33bb6	329	32	)	)	-RRB-
cord-018265-twp33bb6	329	33	is	be	VBZ
cord-018265-twp33bb6	329	34	one	one	CD
cord-018265-twp33bb6	329	35	of	of	IN
cord-018265-twp33bb6	329	36	the	the	DT
cord-018265-twp33bb6	329	37	disadvantages	disadvantage	NNS
cord-018265-twp33bb6	329	38	that	that	WDT
cord-018265-twp33bb6	329	39	reverse	reverse	VBP
cord-018265-twp33bb6	329	40	vaccinology	vaccinology	NN
cord-018265-twp33bb6	329	41	has	have	VBZ
cord-018265-twp33bb6	329	42	solved	solve	VBN
cord-018265-twp33bb6	329	43	.	.	.
cord-018265-twp33bb6	330	1	The	the	DT
cord-018265-twp33bb6	330	2	conventional	conventional	JJ
cord-018265-twp33bb6	330	3	method	method	NN
cord-018265-twp33bb6	330	4	usually	usually	RB
cord-018265-twp33bb6	330	5	requires	require	VBZ
cord-018265-twp33bb6	330	6	15	15	CD
cord-018265-twp33bb6	330	7	-	-	SYM
cord-018265-twp33bb6	330	8	20	20	CD
cord-018265-twp33bb6	330	9	years	year	NNS
cord-018265-twp33bb6	330	10	to	to	TO
cord-018265-twp33bb6	330	11	arrive	arrive	VB
cord-018265-twp33bb6	330	12	to	to	IN
cord-018265-twp33bb6	330	13	a	a	DT
cord-018265-twp33bb6	330	14	clinical	clinical	JJ
cord-018265-twp33bb6	330	15	trial	trial	NN
cord-018265-twp33bb6	330	16	,	,	,
cord-018265-twp33bb6	330	17	whereas	whereas	IN
cord-018265-twp33bb6	330	18	reverse	reverse	JJ
cord-018265-twp33bb6	330	19	vaccinology	vaccinology	NN
cord-018265-twp33bb6	330	20	reduces	reduce	VBZ
cord-018265-twp33bb6	330	21	the	the	DT
cord-018265-twp33bb6	330	22	process	process	NN
cord-018265-twp33bb6	330	23	to	to	IN
cord-018265-twp33bb6	330	24	approximately	approximately	RB
cord-018265-twp33bb6	330	25	5	5	CD
cord-018265-twp33bb6	330	26	years	year	NNS
cord-018265-twp33bb6	330	27	.	.	.
cord-018265-twp33bb6	331	1	Reverse	reverse	JJ
cord-018265-twp33bb6	331	2	vaccinology	vaccinology	NN
cord-018265-twp33bb6	331	3	also	also	RB
cord-018265-twp33bb6	331	4	allows	allow	VBZ
cord-018265-twp33bb6	331	5	the	the	DT
cord-018265-twp33bb6	331	6	identification	identification	NN
cord-018265-twp33bb6	331	7	of	of	IN
cord-018265-twp33bb6	331	8	hundreds	hundred	NNS
cord-018265-twp33bb6	331	9	of	of	IN
cord-018265-twp33bb6	331	10	potential	potential	JJ
cord-018265-twp33bb6	331	11	candidates	candidate	NNS
cord-018265-twp33bb6	331	12	in	in	IN
cord-018265-twp33bb6	331	13	a	a	DT
cord-018265-twp33bb6	331	14	few	few	JJ
cord-018265-twp33bb6	331	15	days	day	NNS
cord-018265-twp33bb6	331	16	,	,	,
cord-018265-twp33bb6	331	17	in	in	IN
cord-018265-twp33bb6	331	18	comparison	comparison	NN
cord-018265-twp33bb6	331	19	with	with	IN
cord-018265-twp33bb6	331	20	the	the	DT
cord-018265-twp33bb6	331	21	small	small	JJ
cord-018265-twp33bb6	331	22	number	number	NN
cord-018265-twp33bb6	331	23	of	of	IN
cord-018265-twp33bb6	331	24	antigens	antigen	NNS
cord-018265-twp33bb6	331	25	that	that	IN
cord-018265-twp33bb6	331	26	conventional	conventional	JJ
cord-018265-twp33bb6	331	27	approaches	approach	NNS
cord-018265-twp33bb6	331	28	have	have	VBP
cord-018265-twp33bb6	331	29	provided	provide	VBN
cord-018265-twp33bb6	331	30	after	after	IN
cord-018265-twp33bb6	331	31	decades	decade	NNS
cord-018265-twp33bb6	331	32	of	of	IN
cord-018265-twp33bb6	331	33	research	research	NN
cord-018265-twp33bb6	331	34	.	.	.
cord-018265-twp33bb6	332	1	Moreover	moreover	RB
cord-018265-twp33bb6	332	2	,	,	,
cord-018265-twp33bb6	332	3	reverse	reverse	VB
cord-018265-twp33bb6	332	4	vaccinology	vaccinology	NN
cord-018265-twp33bb6	332	5	offers	offer	VBZ
cord-018265-twp33bb6	332	6	the	the	DT
cord-018265-twp33bb6	332	7	possibility	possibility	NN
cord-018265-twp33bb6	332	8	to	to	TO
cord-018265-twp33bb6	332	9	select	select	VB
cord-018265-twp33bb6	332	10	potential	potential	JJ
cord-018265-twp33bb6	332	11	candidates	candidate	NNS
cord-018265-twp33bb6	332	12	independent	independent	JJ
cord-018265-twp33bb6	332	13	of	of	IN
cord-018265-twp33bb6	332	14	their	-PRON-	PRP$
cord-018265-twp33bb6	332	15	expression	expression	NN
cord-018265-twp33bb6	332	16	levels	level	NNS
cord-018265-twp33bb6	332	17	or	or	CC
cord-018265-twp33bb6	332	18	purification	purification	NN
cord-018265-twp33bb6	332	19	easiness	easiness	NN
cord-018265-twp33bb6	332	20	.	.	.
cord-018265-twp33bb6	333	1	The	the	DT
cord-018265-twp33bb6	333	2	reverse	reverse	JJ
cord-018265-twp33bb6	333	3	vaccinology	vaccinology	NN
cord-018265-twp33bb6	333	4	approach	approach	NN
cord-018265-twp33bb6	333	5	has	have	VBZ
cord-018265-twp33bb6	333	6	proved	prove	VBN
cord-018265-twp33bb6	333	7	its	-PRON-	PRP$
cord-018265-twp33bb6	333	8	usefulness	usefulness	NN
cord-018265-twp33bb6	333	9	in	in	IN
cord-018265-twp33bb6	333	10	the	the	DT
cord-018265-twp33bb6	333	11	field	field	NN
cord-018265-twp33bb6	333	12	for	for	IN
cord-018265-twp33bb6	333	13	both	both	CC
cord-018265-twp33bb6	333	14	viral	viral	JJ
cord-018265-twp33bb6	333	15	and	and	CC
cord-018265-twp33bb6	333	16	bacterial	bacterial	JJ
cord-018265-twp33bb6	333	17	pathogens	pathogen	NNS
cord-018265-twp33bb6	333	18	(	(	-LRB-
cord-018265-twp33bb6	333	19	e.g.	e.g.	IN
cord-018265-twp33bb6	333	20	hepatitis	hepatitis	NN
cord-018265-twp33bb6	333	21	C	C	NNP
cord-018265-twp33bb6	333	22	virus	virus	NN
cord-018265-twp33bb6	333	23	,	,	,
cord-018265-twp33bb6	333	24	Group	Group	NNP
cord-018265-twp33bb6	333	25	B	B	NNP
cord-018265-twp33bb6	333	26	meningococci	meningococci	NNP
cord-018265-twp33bb6	333	27	,	,	,
cord-018265-twp33bb6	333	28	group	group	NN
cord-018265-twp33bb6	333	29	B	b	NN
cord-018265-twp33bb6	333	30	streptococci	streptococcus	NNS
cord-018265-twp33bb6	333	31	)	)	-RRB-
cord-018265-twp33bb6	333	32	[	[	-LRB-
cord-018265-twp33bb6	333	33	123	123	CD
cord-018265-twp33bb6	333	34	,	,	,
cord-018265-twp33bb6	333	35	124	124	CD
cord-018265-twp33bb6	333	36	]	]	-RRB-
cord-018265-twp33bb6	333	37	.	.	.
cord-018265-twp33bb6	334	1	Reverse	reverse	JJ
cord-018265-twp33bb6	334	2	vaccinology	vaccinology	NN
cord-018265-twp33bb6	334	3	has	have	VBZ
cord-018265-twp33bb6	334	4	also	also	RB
cord-018265-twp33bb6	334	5	become	become	VBN
cord-018265-twp33bb6	334	6	an	an	DT
cord-018265-twp33bb6	334	7	essential	essential	JJ
cord-018265-twp33bb6	334	8	tool	tool	NN
cord-018265-twp33bb6	334	9	for	for	IN
cord-018265-twp33bb6	334	10	several	several	JJ
cord-018265-twp33bb6	334	11	vaccine	vaccine	NN
cord-018265-twp33bb6	334	12	development	development	NN
cord-018265-twp33bb6	334	13	projects	project	NNS
cord-018265-twp33bb6	334	14	against	against	IN
cord-018265-twp33bb6	334	15	agents	agent	NNS
cord-018265-twp33bb6	334	16	causing	cause	VBG
cord-018265-twp33bb6	334	17	community	community	NN
cord-018265-twp33bb6	334	18	-	-	HYPH
cord-018265-twp33bb6	334	19	acquired	acquire	VBN
cord-018265-twp33bb6	334	20	pneumonia	pneumonia	NN
cord-018265-twp33bb6	334	21	(	(	-LRB-
cord-018265-twp33bb6	334	22	e.g.	e.g.	RB
cord-018265-twp33bb6	334	23	,	,	,
cord-018265-twp33bb6	334	24	C.	C.	NNP
cord-018265-twp33bb6	334	25	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	334	26	,	,	,
cord-018265-twp33bb6	334	27	streptococci	streptococcus	NNS
cord-018265-twp33bb6	334	28	)	)	-RRB-
cord-018265-twp33bb6	334	29	.	.	.
cord-018265-twp33bb6	335	1	The	the	DT
cord-018265-twp33bb6	335	2	potential	potential	JJ
cord-018265-twp33bb6	335	3	and	and	CC
cord-018265-twp33bb6	335	4	speed	speed	NN
cord-018265-twp33bb6	335	5	of	of	IN
cord-018265-twp33bb6	335	6	genomic	genomic	NN
cord-018265-twp33bb6	335	7	-	-	HYPH
cord-018265-twp33bb6	335	8	based	base	VBN
cord-018265-twp33bb6	335	9	approaches	approach	NNS
cord-018265-twp33bb6	335	10	was	be	VBD
cord-018265-twp33bb6	335	11	also	also	RB
cord-018265-twp33bb6	335	12	shown	show	VBN
cord-018265-twp33bb6	335	13	when	when	WRB
cord-018265-twp33bb6	335	14	the	the	DT
cord-018265-twp33bb6	335	15	nucleotide	nucleotide	JJ
cord-018265-twp33bb6	335	16	sequence	sequence	NN
cord-018265-twp33bb6	335	17	of	of	IN
cord-018265-twp33bb6	335	18	the	the	DT
cord-018265-twp33bb6	335	19	coronavirus	coronavirus	NN
cord-018265-twp33bb6	335	20	causing	cause	VBG
cord-018265-twp33bb6	335	21	SARS	SARS	NNP
cord-018265-twp33bb6	335	22	was	be	VBD
cord-018265-twp33bb6	335	23	made	make	VBN
cord-018265-twp33bb6	335	24	available	available	JJ
cord-018265-twp33bb6	335	25	in	in	IN
cord-018265-twp33bb6	335	26	less	less	JJR
cord-018265-twp33bb6	335	27	than	than	IN
cord-018265-twp33bb6	335	28	one	one	CD
cord-018265-twp33bb6	335	29	month	month	NN
cord-018265-twp33bb6	335	30	.	.	.
cord-018265-twp33bb6	336	1	In	in	IN
cord-018265-twp33bb6	336	2	addition	addition	NN
cord-018265-twp33bb6	336	3	,	,	,
cord-018265-twp33bb6	336	4	the	the	DT
cord-018265-twp33bb6	336	5	increasing	increase	VBG
cord-018265-twp33bb6	336	6	number	number	NN
cord-018265-twp33bb6	336	7	of	of	IN
cord-018265-twp33bb6	336	8	available	available	JJ
cord-018265-twp33bb6	336	9	genomes	genome	NNS
cord-018265-twp33bb6	336	10	from	from	IN
cord-018265-twp33bb6	336	11	bacteria	bacteria	NNS
cord-018265-twp33bb6	336	12	and	and	CC
cord-018265-twp33bb6	336	13	viruses	virus	NNS
cord-018265-twp33bb6	336	14	would	would	MD
cord-018265-twp33bb6	336	15	allow	allow	VB
cord-018265-twp33bb6	336	16	comparative	comparative	JJ
cord-018265-twp33bb6	336	17	genomic	genomic	JJ
cord-018265-twp33bb6	336	18	studies	study	NNS
cord-018265-twp33bb6	336	19	,	,	,
cord-018265-twp33bb6	336	20	thereby	thereby	RB
cord-018265-twp33bb6	336	21	providing	provide	VBG
cord-018265-twp33bb6	336	22	hints	hint	NNS
cord-018265-twp33bb6	336	23	on	on	IN
cord-018265-twp33bb6	336	24	conserved	conserved	JJ
cord-018265-twp33bb6	336	25	protein	protein	NN
cord-018265-twp33bb6	336	26	families	family	NNS
cord-018265-twp33bb6	336	27	and/or	and/or	CC
cord-018265-twp33bb6	336	28	functional	functional	JJ
cord-018265-twp33bb6	336	29	domains	domain	NNS
cord-018265-twp33bb6	336	30	.	.	.
cord-018265-twp33bb6	337	1	This	this	DT
cord-018265-twp33bb6	337	2	would	would	MD
cord-018265-twp33bb6	337	3	facilitate	facilitate	VB
cord-018265-twp33bb6	337	4	the	the	DT
cord-018265-twp33bb6	337	5	generation	generation	NN
cord-018265-twp33bb6	337	6	of	of	IN
cord-018265-twp33bb6	337	7	vaccines	vaccine	NNS
cord-018265-twp33bb6	337	8	using	use	VBG
cord-018265-twp33bb6	337	9	immunogens	immunogen	NNS
cord-018265-twp33bb6	337	10	covering	cover	VBG
cord-018265-twp33bb6	337	11	multiple	multiple	JJ
cord-018265-twp33bb6	337	12	micro	micro	NNS
cord-018265-twp33bb6	337	13	-	-	HYPH
cord-018265-twp33bb6	337	14	organisms	organism	NNS
cord-018265-twp33bb6	337	15	[	[	-LRB-
cord-018265-twp33bb6	337	16	125	125	CD
cord-018265-twp33bb6	337	17	]	]	-RRB-
cord-018265-twp33bb6	337	18	.	.	.
cord-018265-twp33bb6	338	1	Despite	despite	IN
cord-018265-twp33bb6	338	2	the	the	DT
cord-018265-twp33bb6	338	3	incredible	incredible	JJ
cord-018265-twp33bb6	338	4	potential	potential	NN
cord-018265-twp33bb6	338	5	of	of	IN
cord-018265-twp33bb6	338	6	reverse	reverse	JJ
cord-018265-twp33bb6	338	7	vaccinology	vaccinology	NN
cord-018265-twp33bb6	338	8	,	,	,
cord-018265-twp33bb6	338	9	this	this	DT
cord-018265-twp33bb6	338	10	approach	approach	NN
cord-018265-twp33bb6	338	11	also	also	RB
cord-018265-twp33bb6	338	12	has	have	VBZ
cord-018265-twp33bb6	338	13	some	some	DT
cord-018265-twp33bb6	338	14	important	important	JJ
cord-018265-twp33bb6	338	15	limitations	limitation	NNS
cord-018265-twp33bb6	338	16	(	(	-LRB-
cord-018265-twp33bb6	338	17	Tab	Tab	NNP
cord-018265-twp33bb6	338	18	.	.	.
cord-018265-twp33bb6	338	19	1	1	CD
cord-018265-twp33bb6	338	20	)	)	-RRB-
cord-018265-twp33bb6	338	21	.	.	.
cord-018265-twp33bb6	339	1	Among	among	IN
cord-018265-twp33bb6	339	2	them	-PRON-	PRP
cord-018265-twp33bb6	339	3	is	be	VBZ
cord-018265-twp33bb6	339	4	the	the	DT
cord-018265-twp33bb6	339	5	fact	fact	NN
cord-018265-twp33bb6	339	6	that	that	IN
cord-018265-twp33bb6	339	7	it	-PRON-	PRP
cord-018265-twp33bb6	339	8	is	be	VBZ
cord-018265-twp33bb6	339	9	not	not	RB
cord-018265-twp33bb6	339	10	be	be	VB
cord-018265-twp33bb6	339	11	possible	possible	JJ
cord-018265-twp33bb6	339	12	to	to	TO
cord-018265-twp33bb6	339	13	identify	identify	VB
cord-018265-twp33bb6	339	14	non	non	JJ
cord-018265-twp33bb6	339	15	-	-	JJ
cord-018265-twp33bb6	339	16	protein	protein	JJ
cord-018265-twp33bb6	339	17	antigens	antigen	NNS
cord-018265-twp33bb6	339	18	(	(	-LRB-
cord-018265-twp33bb6	339	19	e.g.	e.g.	RB
cord-018265-twp33bb6	339	20	,	,	,
cord-018265-twp33bb6	339	21	PS	PS	NNP
cord-018265-twp33bb6	339	22	,	,	,
cord-018265-twp33bb6	339	23	glycolipids	glycolipid	NNS
cord-018265-twp33bb6	339	24	)	)	-RRB-
cord-018265-twp33bb6	339	25	,	,	,
cord-018265-twp33bb6	339	26	which	which	WDT
cord-018265-twp33bb6	339	27	are	be	VBP
cord-018265-twp33bb6	339	28	the	the	DT
cord-018265-twp33bb6	339	29	cornerstone	cornerstone	NN
cord-018265-twp33bb6	339	30	for	for	IN
cord-018265-twp33bb6	339	31	many	many	JJ
cord-018265-twp33bb6	339	32	successful	successful	JJ
cord-018265-twp33bb6	339	33	vaccines	vaccine	NNS
cord-018265-twp33bb6	339	34	(	(	-LRB-
cord-018265-twp33bb6	339	35	e.g.	e.g.	RB
cord-018265-twp33bb6	339	36	,	,	,
cord-018265-twp33bb6	339	37	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	339	38	and	and	CC
cord-018265-twp33bb6	339	39	Hib	Hib	NNP
cord-018265-twp33bb6	339	40	vaccines	vaccine	NNS
cord-018265-twp33bb6	339	41	)	)	-RRB-
cord-018265-twp33bb6	339	42	.	.	.
cord-018265-twp33bb6	340	1	Currently	currently	RB
cord-018265-twp33bb6	340	2	available	available	JJ
cord-018265-twp33bb6	340	3	influenza	influenza	NN
cord-018265-twp33bb6	340	4	vaccines	vaccine	NNS
cord-018265-twp33bb6	340	5	(	(	-LRB-
cord-018265-twp33bb6	340	6	see	see	VB
cord-018265-twp33bb6	340	7	above	above	RB
cord-018265-twp33bb6	340	8	)	)	-RRB-
cord-018265-twp33bb6	340	9	are	be	VBP
cord-018265-twp33bb6	340	10	based	base	VBN
cord-018265-twp33bb6	340	11	on	on	IN
cord-018265-twp33bb6	340	12	inactivated	inactivate	VBN
cord-018265-twp33bb6	340	13	viruses	virus	NNS
cord-018265-twp33bb6	340	14	,	,	,
cord-018265-twp33bb6	340	15	and	and	CC
cord-018265-twp33bb6	340	16	,	,	,
cord-018265-twp33bb6	340	17	more	more	RBR
cord-018265-twp33bb6	340	18	recently	recently	RB
cord-018265-twp33bb6	340	19	,	,	,
cord-018265-twp33bb6	340	20	attenuated	attenuated	JJ
cord-018265-twp33bb6	340	21	ca	ca	NN
cord-018265-twp33bb6	340	22	viruses	virus	NNS
cord-018265-twp33bb6	340	23	and	and	CC
cord-018265-twp33bb6	340	24	virosomes	virosome	NNS
cord-018265-twp33bb6	340	25	.	.	.
cord-018265-twp33bb6	341	1	All	all	PDT
cord-018265-twp33bb6	341	2	these	these	DT
cord-018265-twp33bb6	341	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	341	4	exploit	exploit	VBP
cord-018265-twp33bb6	341	5	the	the	DT
cord-018265-twp33bb6	341	6	same	same	JJ
cord-018265-twp33bb6	341	7	starting	starting	NN
cord-018265-twp33bb6	341	8	material	material	NN
cord-018265-twp33bb6	341	9	(	(	-LRB-
cord-018265-twp33bb6	341	10	wild	wild	JJ
cord-018265-twp33bb6	341	11	-	-	HYPH
cord-018265-twp33bb6	341	12	type	type	NN
cord-018265-twp33bb6	341	13	virus	virus	NN
cord-018265-twp33bb6	341	14	)	)	-RRB-
cord-018265-twp33bb6	341	15	,	,	,
cord-018265-twp33bb6	341	16	which	which	WDT
cord-018265-twp33bb6	341	17	is	be	VBZ
cord-018265-twp33bb6	341	18	inactivated	inactivate	VBN
cord-018265-twp33bb6	341	19	or	or	CC
cord-018265-twp33bb6	341	20	attenuated	attenuate	VBN
cord-018265-twp33bb6	341	21	.	.	.
cord-018265-twp33bb6	342	1	The	the	DT
cord-018265-twp33bb6	342	2	last	last	JJ
cord-018265-twp33bb6	342	3	approach	approach	NN
cord-018265-twp33bb6	342	4	consists	consist	VBZ
cord-018265-twp33bb6	342	5	in	in	IN
cord-018265-twp33bb6	342	6	the	the	DT
cord-018265-twp33bb6	342	7	co	co	NN
cord-018265-twp33bb6	342	8	-	-	NN
cord-018265-twp33bb6	342	9	infection	infection	NN
cord-018265-twp33bb6	342	10	of	of	IN
cord-018265-twp33bb6	342	11	chicken	chicken	NN
cord-018265-twp33bb6	342	12	eggs	egg	NNS
cord-018265-twp33bb6	342	13	with	with	IN
cord-018265-twp33bb6	342	14	the	the	DT
cord-018265-twp33bb6	342	15	new	new	JJ
cord-018265-twp33bb6	342	16	isolate	isolate	NN
cord-018265-twp33bb6	342	17	and	and	CC
cord-018265-twp33bb6	342	18	a	a	DT
cord-018265-twp33bb6	342	19	master	master	NN
cord-018265-twp33bb6	342	20	attenuated	attenuate	VBN
cord-018265-twp33bb6	342	21	strain	strain	NN
cord-018265-twp33bb6	342	22	,	,	,
cord-018265-twp33bb6	342	23	and	and	CC
cord-018265-twp33bb6	342	24	subsequent	subsequent	JJ
cord-018265-twp33bb6	342	25	selection	selection	NN
cord-018265-twp33bb6	342	26	for	for	IN
cord-018265-twp33bb6	342	27	re	re	NN
cord-018265-twp33bb6	342	28	-	-	JJ
cord-018265-twp33bb6	342	29	assorted	assorted	JJ
cord-018265-twp33bb6	342	30	viruses	virus	NNS
cord-018265-twp33bb6	342	31	with	with	IN
cord-018265-twp33bb6	342	32	the	the	DT
cord-018265-twp33bb6	342	33	desired	desire	VBN
cord-018265-twp33bb6	342	34	genotype	genotype	NN
cord-018265-twp33bb6	342	35	/	/	SYM
cord-018265-twp33bb6	342	36	phenotype	phenotype	NN
cord-018265-twp33bb6	342	37	.	.	.
cord-018265-twp33bb6	343	1	However	however	RB
cord-018265-twp33bb6	343	2	,	,	,
cord-018265-twp33bb6	343	3	the	the	DT
cord-018265-twp33bb6	343	4	virulence	virulence	NN
cord-018265-twp33bb6	343	5	of	of	IN
cord-018265-twp33bb6	343	6	certain	certain	JJ
cord-018265-twp33bb6	343	7	virus	virus	NN
cord-018265-twp33bb6	343	8	strains	strain	NNS
cord-018265-twp33bb6	343	9	,	,	,
cord-018265-twp33bb6	343	10	such	such	JJ
cord-018265-twp33bb6	343	11	as	as	IN
cord-018265-twp33bb6	343	12	the	the	DT
cord-018265-twp33bb6	343	13	H5N1	H5N1	NNP
cord-018265-twp33bb6	343	14	,	,	,
cord-018265-twp33bb6	343	15	renders	render	VBZ
cord-018265-twp33bb6	343	16	difficult	difficult	JJ
cord-018265-twp33bb6	343	17	the	the	DT
cord-018265-twp33bb6	343	18	implementation	implementation	NN
cord-018265-twp33bb6	343	19	of	of	IN
cord-018265-twp33bb6	343	20	this	this	DT
cord-018265-twp33bb6	343	21	traditional	traditional	JJ
cord-018265-twp33bb6	343	22	strategy	strategy	NN
cord-018265-twp33bb6	343	23	.	.	.
cord-018265-twp33bb6	344	1	The	the	DT
cord-018265-twp33bb6	344	2	use	use	NN
cord-018265-twp33bb6	344	3	of	of	IN
cord-018265-twp33bb6	344	4	reverse	reverse	JJ
cord-018265-twp33bb6	344	5	genetics	genetics	NN
cord-018265-twp33bb6	344	6	represents	represent	VBZ
cord-018265-twp33bb6	344	7	a	a	DT
cord-018265-twp33bb6	344	8	valid	valid	JJ
cord-018265-twp33bb6	344	9	alternative	alternative	NN
cord-018265-twp33bb6	344	10	for	for	IN
cord-018265-twp33bb6	344	11	the	the	DT
cord-018265-twp33bb6	344	12	generation	generation	NN
cord-018265-twp33bb6	344	13	of	of	IN
cord-018265-twp33bb6	344	14	vaccines	vaccine	NNS
cord-018265-twp33bb6	344	15	against	against	IN
cord-018265-twp33bb6	344	16	RNA	RNA	NNP
cord-018265-twp33bb6	344	17	respiratory	respiratory	JJ
cord-018265-twp33bb6	344	18	viruses	virus	NNS
cord-018265-twp33bb6	344	19	,	,	,
cord-018265-twp33bb6	344	20	such	such	JJ
cord-018265-twp33bb6	344	21	as	as	IN
cord-018265-twp33bb6	344	22	the	the	DT
cord-018265-twp33bb6	344	23	influenza	influenza	NN
cord-018265-twp33bb6	344	24	virus	virus	NN
cord-018265-twp33bb6	344	25	,	,	,
cord-018265-twp33bb6	344	26	PIV	PIV	NNP
cord-018265-twp33bb6	344	27	and	and	CC
cord-018265-twp33bb6	344	28	RSV	RSV	NNP
cord-018265-twp33bb6	344	29	.	.	.
cord-018265-twp33bb6	345	1	It	-PRON-	PRP
cord-018265-twp33bb6	345	2	consists	consist	VBZ
cord-018265-twp33bb6	345	3	in	in	IN
cord-018265-twp33bb6	345	4	the	the	DT
cord-018265-twp33bb6	345	5	production	production	NN
cord-018265-twp33bb6	345	6	of	of	IN
cord-018265-twp33bb6	345	7	the	the	DT
cord-018265-twp33bb6	345	8	virus	virus	NN
cord-018265-twp33bb6	345	9	from	from	IN
cord-018265-twp33bb6	345	10	cloned	clone	VBN
cord-018265-twp33bb6	345	11	DNA	DNA	NNP
cord-018265-twp33bb6	345	12	[	[	-LRB-
cord-018265-twp33bb6	345	13	126	126	CD
cord-018265-twp33bb6	345	14	]	]	-RRB-
cord-018265-twp33bb6	345	15	,	,	,
cord-018265-twp33bb6	345	16	thereby	thereby	RB
cord-018265-twp33bb6	345	17	allowing	allow	VBG
cord-018265-twp33bb6	345	18	the	the	DT
cord-018265-twp33bb6	345	19	development	development	NN
cord-018265-twp33bb6	345	20	of	of	IN
cord-018265-twp33bb6	345	21	vaccines	vaccine	NNS
cord-018265-twp33bb6	345	22	against	against	IN
cord-018265-twp33bb6	345	23	any	any	DT
cord-018265-twp33bb6	345	24	pandemic	pandemic	NN
cord-018265-twp33bb6	345	25	viral	viral	JJ
cord-018265-twp33bb6	345	26	strain	strain	NN
cord-018265-twp33bb6	345	27	.	.	.
cord-018265-twp33bb6	346	1	In	in	IN
cord-018265-twp33bb6	346	2	some	some	DT
cord-018265-twp33bb6	346	3	cases	case	NNS
cord-018265-twp33bb6	346	4	(	(	-LRB-
cord-018265-twp33bb6	346	5	e.g.	e.g.	RB
cord-018265-twp33bb6	346	6	,	,	,
cord-018265-twp33bb6	346	7	avian	avian	JJ
cord-018265-twp33bb6	346	8	H5N1	H5N1	NNP
cord-018265-twp33bb6	346	9	)	)	-RRB-
cord-018265-twp33bb6	347	1	an	an	DT
cord-018265-twp33bb6	347	2	additional	additional	JJ
cord-018265-twp33bb6	347	3	mutagenesis	mutagenesis	NN
cord-018265-twp33bb6	347	4	step	step	NN
cord-018265-twp33bb6	347	5	would	would	MD
cord-018265-twp33bb6	347	6	be	be	VB
cord-018265-twp33bb6	347	7	required	require	VBN
cord-018265-twp33bb6	347	8	to	to	TO
cord-018265-twp33bb6	347	9	attenuate	attenuate	VB
cord-018265-twp33bb6	347	10	its	-PRON-	PRP$
cord-018265-twp33bb6	347	11	virulence	virulence	NN
cord-018265-twp33bb6	347	12	[	[	-LRB-
cord-018265-twp33bb6	347	13	127	127	CD
cord-018265-twp33bb6	347	14	]	]	-RRB-
cord-018265-twp33bb6	347	15	.	.	.
cord-018265-twp33bb6	348	1	Then	then	RB
cord-018265-twp33bb6	348	2	,	,	,
cord-018265-twp33bb6	348	3	the	the	DT
cord-018265-twp33bb6	348	4	new	new	JJ
cord-018265-twp33bb6	348	5	HA	HA	NNP
cord-018265-twp33bb6	348	6	and	and	CC
cord-018265-twp33bb6	348	7	NA	NA	NNP
cord-018265-twp33bb6	348	8	segments	segment	NNS
cord-018265-twp33bb6	348	9	would	would	MD
cord-018265-twp33bb6	348	10	be	be	VB
cord-018265-twp33bb6	348	11	transferred	transfer	VBN
cord-018265-twp33bb6	348	12	into	into	IN
cord-018265-twp33bb6	348	13	an	an	DT
cord-018265-twp33bb6	348	14	appropriate	appropriate	JJ
cord-018265-twp33bb6	348	15	influenza	influenza	NN
cord-018265-twp33bb6	348	16	A	a	DT
cord-018265-twp33bb6	348	17	virus	virus	NN
cord-018265-twp33bb6	348	18	master	master	NN
cord-018265-twp33bb6	348	19	strain	strain	NN
cord-018265-twp33bb6	348	20	adapted	adapt	VBN
cord-018265-twp33bb6	348	21	to	to	TO
cord-018265-twp33bb6	348	22	grow	grow	VB
cord-018265-twp33bb6	348	23	in	in	IN
cord-018265-twp33bb6	348	24	a	a	DT
cord-018265-twp33bb6	348	25	cell	cell	NN
cord-018265-twp33bb6	348	26	line	line	NN
cord-018265-twp33bb6	348	27	.	.	.
cord-018265-twp33bb6	349	1	The	the	DT
cord-018265-twp33bb6	349	2	final	final	JJ
cord-018265-twp33bb6	349	3	re	re	NN
cord-018265-twp33bb6	349	4	-	-	JJ
cord-018265-twp33bb6	349	5	assorted	assorted	JJ
cord-018265-twp33bb6	349	6	virus	virus	NN
cord-018265-twp33bb6	349	7	will	will	MD
cord-018265-twp33bb6	349	8	have	have	VB
cord-018265-twp33bb6	349	9	the	the	DT
cord-018265-twp33bb6	349	10	antigenic	antigenic	JJ
cord-018265-twp33bb6	349	11	specificity	specificity	NN
cord-018265-twp33bb6	349	12	of	of	IN
cord-018265-twp33bb6	349	13	the	the	DT
cord-018265-twp33bb6	349	14	pandemic	pandemic	NN
cord-018265-twp33bb6	349	15	strain	strain	NN
cord-018265-twp33bb6	349	16	and	and	CC
cord-018265-twp33bb6	349	17	the	the	DT
cord-018265-twp33bb6	349	18	growth	growth	NN
cord-018265-twp33bb6	349	19	characteristics	characteristic	NNS
cord-018265-twp33bb6	349	20	of	of	IN
cord-018265-twp33bb6	349	21	the	the	DT
cord-018265-twp33bb6	349	22	master	master	NN
cord-018265-twp33bb6	349	23	strain	strain	NN
cord-018265-twp33bb6	349	24	[	[	-LRB-
cord-018265-twp33bb6	349	25	128	128	CD
cord-018265-twp33bb6	349	26	,	,	,
cord-018265-twp33bb6	349	27	129	129	CD
cord-018265-twp33bb6	349	28	]	]	-RRB-
cord-018265-twp33bb6	349	29	.	.	.
cord-018265-twp33bb6	350	1	This	this	DT
cord-018265-twp33bb6	350	2	technology	technology	NN
cord-018265-twp33bb6	350	3	would	would	MD
cord-018265-twp33bb6	350	4	also	also	RB
cord-018265-twp33bb6	350	5	allow	allow	VB
cord-018265-twp33bb6	350	6	production	production	NN
cord-018265-twp33bb6	350	7	of	of	IN
cord-018265-twp33bb6	350	8	the	the	DT
cord-018265-twp33bb6	350	9	influenza	influenza	NN
cord-018265-twp33bb6	350	10	vaccine	vaccine	NN
cord-018265-twp33bb6	350	11	in	in	IN
cord-018265-twp33bb6	350	12	cells	cell	NNS
cord-018265-twp33bb6	350	13	that	that	WDT
cord-018265-twp33bb6	350	14	are	be	VBP
cord-018265-twp33bb6	350	15	co	co	VBN
cord-018265-twp33bb6	350	16	-	-	VBN
cord-018265-twp33bb6	350	17	transfected	transfecte	VBN
cord-018265-twp33bb6	350	18	with	with	IN
cord-018265-twp33bb6	350	19	plasmids	plasmid	NNS
cord-018265-twp33bb6	350	20	encoding	encode	VBG
cord-018265-twp33bb6	350	21	for	for	IN
cord-018265-twp33bb6	350	22	different	different	JJ
cord-018265-twp33bb6	350	23	frag-	frag-	NN
cord-018265-twp33bb6	350	24	[	[	-LRB-
cord-018265-twp33bb6	350	25	130	130	CD
cord-018265-twp33bb6	350	26	]	]	-RRB-
cord-018265-twp33bb6	350	27	.	.	.
cord-018265-twp33bb6	351	1	Therefore	therefore	RB
cord-018265-twp33bb6	351	2	,	,	,
cord-018265-twp33bb6	351	3	the	the	DT
cord-018265-twp33bb6	351	4	complete	complete	JJ
cord-018265-twp33bb6	351	5	genome	genome	NN
cord-018265-twp33bb6	351	6	is	be	VBZ
cord-018265-twp33bb6	351	7	inside	inside	IN
cord-018265-twp33bb6	351	8	the	the	DT
cord-018265-twp33bb6	351	9	cell	cell	NN
cord-018265-twp33bb6	351	10	and	and	CC
cord-018265-twp33bb6	351	11	virus	virus	NN
cord-018265-twp33bb6	351	12	can	can	MD
cord-018265-twp33bb6	351	13	be	be	VB
cord-018265-twp33bb6	351	14	produced	produce	VBN
cord-018265-twp33bb6	351	15	and	and	CC
cord-018265-twp33bb6	351	16	assembled	assemble	VBN
cord-018265-twp33bb6	351	17	.	.	.
cord-018265-twp33bb6	352	1	One	one	CD
cord-018265-twp33bb6	352	2	of	of	IN
cord-018265-twp33bb6	352	3	the	the	DT
cord-018265-twp33bb6	352	4	main	main	JJ
cord-018265-twp33bb6	352	5	advantages	advantage	NNS
cord-018265-twp33bb6	352	6	is	be	VBZ
cord-018265-twp33bb6	352	7	that	that	IN
cord-018265-twp33bb6	352	8	a	a	DT
cord-018265-twp33bb6	352	9	plasmid	plasmid	NN
cord-018265-twp33bb6	352	10	encoding	encoding	NN
cord-018265-twp33bb6	352	11	for	for	IN
cord-018265-twp33bb6	352	12	HA	HA	NNP
cord-018265-twp33bb6	352	13	and	and	CC
cord-018265-twp33bb6	352	14	NA	NA	NNP
cord-018265-twp33bb6	352	15	can	can	MD
cord-018265-twp33bb6	352	16	be	be	VB
cord-018265-twp33bb6	352	17	easily	easily	RB
cord-018265-twp33bb6	352	18	replaced	replace	VBN
cord-018265-twp33bb6	352	19	.	.	.
cord-018265-twp33bb6	353	1	Therefore	therefore	RB
cord-018265-twp33bb6	353	2	,	,	,
cord-018265-twp33bb6	353	3	re	re	NN
cord-018265-twp33bb6	353	4	-	-	NN
cord-018265-twp33bb6	353	5	assortment	assortment	JJ
cord-018265-twp33bb6	353	6	and	and	CC
cord-018265-twp33bb6	353	7	selection	selection	NN
cord-018265-twp33bb6	353	8	become	become	VBP
cord-018265-twp33bb6	353	9	unnecessary	unnecessary	JJ
cord-018265-twp33bb6	353	10	.	.	.
cord-018265-twp33bb6	354	1	This	this	DT
cord-018265-twp33bb6	354	2	method	method	NN
cord-018265-twp33bb6	354	3	would	would	MD
cord-018265-twp33bb6	354	4	considerably	considerably	RB
cord-018265-twp33bb6	354	5	reduce	reduce	VB
cord-018265-twp33bb6	354	6	the	the	DT
cord-018265-twp33bb6	354	7	time	time	NN
cord-018265-twp33bb6	354	8	for	for	IN
cord-018265-twp33bb6	354	9	vaccine	vaccine	NN
cord-018265-twp33bb6	354	10	production	production	NN
cord-018265-twp33bb6	354	11	,	,	,
cord-018265-twp33bb6	354	12	from	from	IN
cord-018265-twp33bb6	354	13	many	many	JJ
cord-018265-twp33bb6	354	14	months	month	NNS
cord-018265-twp33bb6	354	15	to	to	IN
cord-018265-twp33bb6	354	16	only	only	RB
cord-018265-twp33bb6	354	17	a	a	DT
cord-018265-twp33bb6	354	18	few	few	JJ
cord-018265-twp33bb6	354	19	weeks	week	NNS
cord-018265-twp33bb6	354	20	.	.	.
cord-018265-twp33bb6	355	1	Another	another	DT
cord-018265-twp33bb6	355	2	advantage	advantage	NN
cord-018265-twp33bb6	355	3	would	would	MD
cord-018265-twp33bb6	355	4	be	be	VB
cord-018265-twp33bb6	355	5	the	the	DT
cord-018265-twp33bb6	355	6	simple	simple	JJ
cord-018265-twp33bb6	355	7	manipulation	manipulation	NN
cord-018265-twp33bb6	355	8	of	of	IN
cord-018265-twp33bb6	355	9	the	the	DT
cord-018265-twp33bb6	355	10	genome	genome	NN
cord-018265-twp33bb6	355	11	(	(	-LRB-
cord-018265-twp33bb6	355	12	contained	contain	VBN
cord-018265-twp33bb6	355	13	in	in	IN
cord-018265-twp33bb6	355	14	plasmids	plasmid	NNS
cord-018265-twp33bb6	355	15	)	)	-RRB-
cord-018265-twp33bb6	355	16	,	,	,
cord-018265-twp33bb6	355	17	which	which	WDT
cord-018265-twp33bb6	355	18	would	would	MD
cord-018265-twp33bb6	355	19	enable	enable	VB
cord-018265-twp33bb6	355	20	detoxification	detoxification	NN
cord-018265-twp33bb6	355	21	of	of	IN
cord-018265-twp33bb6	355	22	specific	specific	JJ
cord-018265-twp33bb6	355	23	virulence	virulence	NN
cord-018265-twp33bb6	355	24	factors	factor	NNS
cord-018265-twp33bb6	355	25	.	.	.
cord-018265-twp33bb6	356	1	Similar	similar	JJ
cord-018265-twp33bb6	356	2	approaches	approach	NNS
cord-018265-twp33bb6	356	3	can	can	MD
cord-018265-twp33bb6	356	4	be	be	VB
cord-018265-twp33bb6	356	5	implemented	implement	VBN
cord-018265-twp33bb6	356	6	for	for	IN
cord-018265-twp33bb6	356	7	other	other	JJ
cord-018265-twp33bb6	356	8	viruses	virus	NNS
cord-018265-twp33bb6	356	9	,	,	,
cord-018265-twp33bb6	356	10	such	such	JJ
cord-018265-twp33bb6	356	11	as	as	IN
cord-018265-twp33bb6	356	12	RSV	RSV	NNP
cord-018265-twp33bb6	356	13	,	,	,
cord-018265-twp33bb6	356	14	PIV	PIV	NNP
cord-018265-twp33bb6	356	15	and	and	CC
cord-018265-twp33bb6	356	16	SARS	SARS	NNP
cord-018265-twp33bb6	356	17	-	-	HYPH
cord-018265-twp33bb6	356	18	CoV.	CoV.	NNP
cord-018265-twp33bb6	357	1	However	however	RB
cord-018265-twp33bb6	357	2	,	,	,
cord-018265-twp33bb6	357	3	intellectual	intellectual	JJ
cord-018265-twp33bb6	357	4	property	property	NN
cord-018265-twp33bb6	357	5	and	and	CC
cord-018265-twp33bb6	357	6	liability	liability	NN
cord-018265-twp33bb6	357	7	issues	issue	NNS
cord-018265-twp33bb6	357	8	are	be	VBP
cord-018265-twp33bb6	357	9	still	still	RB
cord-018265-twp33bb6	357	10	obstacles	obstacle	NNS
cord-018265-twp33bb6	357	11	for	for	IN
cord-018265-twp33bb6	357	12	the	the	DT
cord-018265-twp33bb6	357	13	industrial	industrial	JJ
cord-018265-twp33bb6	357	14	development	development	NN
cord-018265-twp33bb6	357	15	of	of	IN
cord-018265-twp33bb6	357	16	reverse	reverse	JJ
cord-018265-twp33bb6	357	17	-	-	HYPH
cord-018265-twp33bb6	357	18	genetics	genetics	NN
cord-018265-twp33bb6	357	19	-	-	HYPH
cord-018265-twp33bb6	357	20	based	base	VBN
cord-018265-twp33bb6	357	21	vaccines	vaccine	NNS
cord-018265-twp33bb6	357	22	[	[	-LRB-
cord-018265-twp33bb6	357	23	131	131	CD
cord-018265-twp33bb6	357	24	]	]	-RRB-
cord-018265-twp33bb6	357	25	.	.	.
cord-018265-twp33bb6	358	1	Furthermore	furthermore	RB
cord-018265-twp33bb6	358	2	,	,	,
cord-018265-twp33bb6	358	3	since	since	IN
cord-018265-twp33bb6	358	4	the	the	DT
cord-018265-twp33bb6	358	5	resulting	result	VBG
cord-018265-twp33bb6	358	6	viruses	virus	NNS
cord-018265-twp33bb6	358	7	are	be	VBP
cord-018265-twp33bb6	358	8	considered	consider	VBN
cord-018265-twp33bb6	358	9	genetically	genetically	RB
cord-018265-twp33bb6	358	10	modified	modify	VBN
cord-018265-twp33bb6	358	11	organisms	organism	NNS
cord-018265-twp33bb6	358	12	,	,	,
cord-018265-twp33bb6	358	13	additional	additional	JJ
cord-018265-twp33bb6	358	14	problems	problem	NNS
cord-018265-twp33bb6	358	15	may	may	MD
cord-018265-twp33bb6	358	16	arise	arise	VB
cord-018265-twp33bb6	358	17	from	from	IN
cord-018265-twp33bb6	358	18	the	the	DT
cord-018265-twp33bb6	358	19	regulatory	regulatory	JJ
cord-018265-twp33bb6	358	20	stand	stand	NN
cord-018265-twp33bb6	358	21	point	point	NN
cord-018265-twp33bb6	358	22	[	[	-LRB-
cord-018265-twp33bb6	358	23	131	131	CD
cord-018265-twp33bb6	358	24	]	]	-RRB-
cord-018265-twp33bb6	358	25	.	.	.
cord-018265-twp33bb6	359	1	Most	Most	JJS
cord-018265-twp33bb6	359	2	of	of	IN
cord-018265-twp33bb6	359	3	the	the	DT
cord-018265-twp33bb6	359	4	infective	infective	JJ
cord-018265-twp33bb6	359	5	agents	agent	NNS
cord-018265-twp33bb6	359	6	are	be	VBP
cord-018265-twp33bb6	359	7	either	either	RB
cord-018265-twp33bb6	359	8	limited	limit	VBN
cord-018265-twp33bb6	359	9	to	to	IN
cord-018265-twp33bb6	359	10	the	the	DT
cord-018265-twp33bb6	359	11	mucosal	mucosal	JJ
cord-018265-twp33bb6	359	12	membranes	membrane	NNS
cord-018265-twp33bb6	359	13	,	,	,
cord-018265-twp33bb6	359	14	or	or	CC
cord-018265-twp33bb6	359	15	need	need	VBP
cord-018265-twp33bb6	359	16	to	to	TO
cord-018265-twp33bb6	359	17	transit	transit	VB
cord-018265-twp33bb6	359	18	across	across	IN
cord-018265-twp33bb6	359	19	them	-PRON-	PRP
cord-018265-twp33bb6	359	20	in	in	IN
cord-018265-twp33bb6	359	21	order	order	NN
cord-018265-twp33bb6	359	22	to	to	TO
cord-018265-twp33bb6	359	23	cause	cause	VB
cord-018265-twp33bb6	359	24	disease	disease	NN
cord-018265-twp33bb6	359	25	.	.	.
cord-018265-twp33bb6	360	1	Therefore	therefore	RB
cord-018265-twp33bb6	360	2	,	,	,
cord-018265-twp33bb6	360	3	it	-PRON-	PRP
cord-018265-twp33bb6	360	4	is	be	VBZ
cord-018265-twp33bb6	360	5	highly	highly	RB
cord-018265-twp33bb6	360	6	desirable	desirable	JJ
cord-018265-twp33bb6	360	7	to	to	TO
cord-018265-twp33bb6	360	8	elicit	elicit	VB
cord-018265-twp33bb6	360	9	an	an	DT
cord-018265-twp33bb6	360	10	efficient	efficient	JJ
cord-018265-twp33bb6	360	11	immune	immune	JJ
cord-018265-twp33bb6	360	12	response	response	NN
cord-018265-twp33bb6	360	13	at	at	IN
cord-018265-twp33bb6	360	14	the	the	DT
cord-018265-twp33bb6	360	15	local	local	JJ
cord-018265-twp33bb6	360	16	site	site	NN
cord-018265-twp33bb6	360	17	in	in	IN
cord-018265-twp33bb6	360	18	which	which	WDT
cord-018265-twp33bb6	360	19	the	the	DT
cord-018265-twp33bb6	360	20	first	first	JJ
cord-018265-twp33bb6	360	21	line	line	NN
cord-018265-twp33bb6	360	22	of	of	IN
cord-018265-twp33bb6	360	23	defence	defence	NN
cord-018265-twp33bb6	360	24	is	be	VBZ
cord-018265-twp33bb6	360	25	laid	lay	VBN
cord-018265-twp33bb6	360	26	.	.	.
cord-018265-twp33bb6	361	1	The	the	DT
cord-018265-twp33bb6	361	2	stimulation	stimulation	NN
cord-018265-twp33bb6	361	3	of	of	IN
cord-018265-twp33bb6	361	4	a	a	DT
cord-018265-twp33bb6	361	5	pathogen	pathogen	NN
cord-018265-twp33bb6	361	6	-	-	HYPH
cord-018265-twp33bb6	361	7	specific	specific	JJ
cord-018265-twp33bb6	361	8	response	response	NN
cord-018265-twp33bb6	361	9	at	at	IN
cord-018265-twp33bb6	361	10	the	the	DT
cord-018265-twp33bb6	361	11	portal	portal	NN
cord-018265-twp33bb6	361	12	of	of	IN
cord-018265-twp33bb6	361	13	entry	entry	NN
cord-018265-twp33bb6	361	14	is	be	VBZ
cord-018265-twp33bb6	361	15	expected	expect	VBN
cord-018265-twp33bb6	361	16	to	to	TO
cord-018265-twp33bb6	361	17	impair	impair	VB
cord-018265-twp33bb6	361	18	infection	infection	NN
cord-018265-twp33bb6	361	19	(	(	-LRB-
cord-018265-twp33bb6	361	20	i.e.	i.e.	FW
cord-018265-twp33bb6	361	21	colonization	colonization	NNP
cord-018265-twp33bb6	361	22	)	)	-RRB-
cord-018265-twp33bb6	361	23	,	,	,
cord-018265-twp33bb6	361	24	thereby	thereby	RB
cord-018265-twp33bb6	361	25	reducing	reduce	VBG
cord-018265-twp33bb6	361	26	the	the	DT
cord-018265-twp33bb6	361	27	risk	risk	NN
cord-018265-twp33bb6	361	28	of	of	IN
cord-018265-twp33bb6	361	29	transmission	transmission	NN
cord-018265-twp33bb6	361	30	to	to	IN
cord-018265-twp33bb6	361	31	susceptible	susceptible	JJ
cord-018265-twp33bb6	361	32	hosts	host	NNS
cord-018265-twp33bb6	361	33	.	.	.
cord-018265-twp33bb6	362	1	Parenterally	Parenterally	NNP
cord-018265-twp33bb6	362	2	administered	administer	VBN
cord-018265-twp33bb6	362	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	362	4	mainly	mainly	RB
cord-018265-twp33bb6	362	5	stimulate	stimulate	VBP
cord-018265-twp33bb6	362	6	systemic	systemic	JJ
cord-018265-twp33bb6	362	7	responses	response	NNS
cord-018265-twp33bb6	362	8	,	,	,
cord-018265-twp33bb6	362	9	whereas	whereas	IN
cord-018265-twp33bb6	362	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	362	11	given	give	VBN
cord-018265-twp33bb6	362	12	by	by	IN
cord-018265-twp33bb6	362	13	the	the	DT
cord-018265-twp33bb6	362	14	mucosal	mucosal	JJ
cord-018265-twp33bb6	362	15	route	route	NN
cord-018265-twp33bb6	362	16	mimic	mimic	VBP
cord-018265-twp33bb6	362	17	natural	natural	JJ
cord-018265-twp33bb6	362	18	infections	infection	NNS
cord-018265-twp33bb6	362	19	,	,	,
cord-018265-twp33bb6	362	20	thereby	thereby	RB
cord-018265-twp33bb6	362	21	leading	lead	VBG
cord-018265-twp33bb6	362	22	to	to	IN
cord-018265-twp33bb6	362	23	efficient	efficient	JJ
cord-018265-twp33bb6	362	24	mucosal	mucosal	JJ
cord-018265-twp33bb6	362	25	and	and	CC
cord-018265-twp33bb6	362	26	systemic	systemic	JJ
cord-018265-twp33bb6	362	27	responses	response	NNS
cord-018265-twp33bb6	362	28	.	.	.
cord-018265-twp33bb6	363	1	Thus	thus	RB
cord-018265-twp33bb6	363	2	,	,	,
cord-018265-twp33bb6	363	3	there	there	EX
cord-018265-twp33bb6	363	4	is	be	VBZ
cord-018265-twp33bb6	363	5	a	a	DT
cord-018265-twp33bb6	363	6	considerable	considerable	JJ
cord-018265-twp33bb6	363	7	interest	interest	NN
cord-018265-twp33bb6	363	8	in	in	IN
cord-018265-twp33bb6	363	9	the	the	DT
cord-018265-twp33bb6	363	10	development	development	NN
cord-018265-twp33bb6	363	11	of	of	IN
cord-018265-twp33bb6	363	12	mucosal	mucosal	JJ
cord-018265-twp33bb6	363	13	vaccines	vaccine	NNS
cord-018265-twp33bb6	363	14	.	.	.
cord-018265-twp33bb6	364	1	However	however	RB
cord-018265-twp33bb6	364	2	,	,	,
cord-018265-twp33bb6	364	3	antigens	antigen	NNS
cord-018265-twp33bb6	364	4	administered	administer	VBN
cord-018265-twp33bb6	364	5	by	by	IN
cord-018265-twp33bb6	364	6	this	this	DT
cord-018265-twp33bb6	364	7	route	route	NN
cord-018265-twp33bb6	364	8	are	be	VBP
cord-018265-twp33bb6	364	9	usually	usually	RB
cord-018265-twp33bb6	364	10	poorly	poorly	RB
cord-018265-twp33bb6	364	11	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	364	12	.	.	.
cord-018265-twp33bb6	365	1	Different	different	JJ
cord-018265-twp33bb6	365	2	strategies	strategy	NNS
cord-018265-twp33bb6	365	3	are	be	VBP
cord-018265-twp33bb6	365	4	being	be	VBG
cord-018265-twp33bb6	365	5	pursued	pursue	VBN
cord-018265-twp33bb6	365	6	to	to	TO
cord-018265-twp33bb6	365	7	overcome	overcome	VB
cord-018265-twp33bb6	365	8	this	this	DT
cord-018265-twp33bb6	365	9	bottleneck	bottleneck	NN
cord-018265-twp33bb6	365	10	,	,	,
cord-018265-twp33bb6	365	11	among	among	IN
cord-018265-twp33bb6	365	12	them	-PRON-	PRP
cord-018265-twp33bb6	365	13	can	can	MD
cord-018265-twp33bb6	365	14	be	be	VB
cord-018265-twp33bb6	365	15	cited	cite	VBN
cord-018265-twp33bb6	365	16	the	the	DT
cord-018265-twp33bb6	365	17	use	use	NN
cord-018265-twp33bb6	365	18	of	of	IN
cord-018265-twp33bb6	365	19	(	(	-LRB-
cord-018265-twp33bb6	365	20	i	i	NN
cord-018265-twp33bb6	365	21	)	)	-RRB-
cord-018265-twp33bb6	365	22	advanced	advance	VBD
cord-018265-twp33bb6	365	23	synthetic	synthetic	JJ
cord-018265-twp33bb6	365	24	delivery	delivery	NN
cord-018265-twp33bb6	365	25	systems	system	NNS
cord-018265-twp33bb6	365	26	,	,	,
cord-018265-twp33bb6	365	27	(	(	-LRB-
cord-018265-twp33bb6	365	28	ii	ii	NN
cord-018265-twp33bb6	365	29	)	)	-RRB-
cord-018265-twp33bb6	365	30	live	live	JJ
cord-018265-twp33bb6	365	31	attenuated	attenuated	JJ
cord-018265-twp33bb6	365	32	bacterial	bacterial	JJ
cord-018265-twp33bb6	365	33	or	or	CC
cord-018265-twp33bb6	365	34	viral	viral	JJ
cord-018265-twp33bb6	365	35	vectors	vector	NNS
cord-018265-twp33bb6	365	36	,	,	,
cord-018265-twp33bb6	365	37	(	(	-LRB-
cord-018265-twp33bb6	365	38	iii	iii	NN
cord-018265-twp33bb6	365	39	)	)	-RRB-
cord-018265-twp33bb6	365	40	bacterial	bacterial	JJ
cord-018265-twp33bb6	365	41	ghosts	ghost	NNS
cord-018265-twp33bb6	365	42	,	,	,
cord-018265-twp33bb6	365	43	(	(	-LRB-
cord-018265-twp33bb6	365	44	iv	iv	LS
cord-018265-twp33bb6	365	45	)	)	-RRB-
cord-018265-twp33bb6	365	46	pseudoviruses	pseudoviruse	NNS
cord-018265-twp33bb6	365	47	and	and	CC
cord-018265-twp33bb6	365	48	(	(	-LRB-
cord-018265-twp33bb6	365	49	v	v	NN
cord-018265-twp33bb6	365	50	)	)	-RRB-
cord-018265-twp33bb6	365	51	mucosal	mucosal	JJ
cord-018265-twp33bb6	365	52	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	365	53	[	[	-LRB-
cord-018265-twp33bb6	365	54	132	132	CD
cord-018265-twp33bb6	365	55	]	]	-RRB-
cord-018265-twp33bb6	365	56	[	[	-LRB-
cord-018265-twp33bb6	365	57	133	133	CD
cord-018265-twp33bb6	365	58	]	]	-RRB-
cord-018265-twp33bb6	365	59	[	[	-LRB-
cord-018265-twp33bb6	365	60	134	134	CD
cord-018265-twp33bb6	365	61	]	]	-RRB-
cord-018265-twp33bb6	365	62	[	[	-LRB-
cord-018265-twp33bb6	365	63	135	135	CD
cord-018265-twp33bb6	365	64	]	]	-RRB-
cord-018265-twp33bb6	365	65	.	.	.
cord-018265-twp33bb6	366	1	Advanced	advanced	JJ
cord-018265-twp33bb6	366	2	synthetic	synthetic	JJ
cord-018265-twp33bb6	366	3	mucosal	mucosal	JJ
cord-018265-twp33bb6	366	4	delivery	delivery	NN
cord-018265-twp33bb6	366	5	systems	system	NNS
cord-018265-twp33bb6	366	6	Particulate	particulate	NN
cord-018265-twp33bb6	366	7	antigens	antigen	NNS
cord-018265-twp33bb6	366	8	are	be	VBP
cord-018265-twp33bb6	366	9	more	more	RBR
cord-018265-twp33bb6	366	10	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	366	11	than	than	IN
cord-018265-twp33bb6	366	12	those	those	DT
cord-018265-twp33bb6	366	13	in	in	IN
cord-018265-twp33bb6	366	14	solution	solution	NN
cord-018265-twp33bb6	366	15	,	,	,
cord-018265-twp33bb6	366	16	due	due	IN
cord-018265-twp33bb6	366	17	to	to	IN
cord-018265-twp33bb6	366	18	their	-PRON-	PRP$
cord-018265-twp33bb6	366	19	vulnerability	vulnerability	NN
cord-018265-twp33bb6	366	20	to	to	IN
cord-018265-twp33bb6	366	21	degradation	degradation	NN
cord-018265-twp33bb6	366	22	by	by	IN
cord-018265-twp33bb6	366	23	enzymes	enzyme	NNS
cord-018265-twp33bb6	366	24	and	and	CC
cord-018265-twp33bb6	366	25	extreme	extreme	JJ
cord-018265-twp33bb6	366	26	pH.	ph.	NN
cord-018265-twp33bb6	367	1	Thus	thus	RB
cord-018265-twp33bb6	367	2	,	,	,
cord-018265-twp33bb6	367	3	it	-PRON-	PRP
cord-018265-twp33bb6	367	4	would	would	MD
cord-018265-twp33bb6	367	5	be	be	VB
cord-018265-twp33bb6	367	6	helpful	helpful	JJ
cord-018265-twp33bb6	367	7	to	to	TO
cord-018265-twp33bb6	367	8	incorporate	incorporate	VB
cord-018265-twp33bb6	367	9	them	-PRON-	PRP
cord-018265-twp33bb6	367	10	into	into	IN
cord-018265-twp33bb6	367	11	a	a	DT
cord-018265-twp33bb6	367	12	protective	protective	JJ
cord-018265-twp33bb6	367	13	vehicle	vehicle	NN
cord-018265-twp33bb6	367	14	.	.	.
cord-018265-twp33bb6	368	1	Often	often	RB
cord-018265-twp33bb6	368	2	,	,	,
cord-018265-twp33bb6	368	3	these	these	DT
cord-018265-twp33bb6	368	4	vehicles	vehicle	NNS
cord-018265-twp33bb6	368	5	do	do	VBP
cord-018265-twp33bb6	368	6	not	not	RB
cord-018265-twp33bb6	368	7	serve	serve	VB
cord-018265-twp33bb6	368	8	only	only	RB
cord-018265-twp33bb6	368	9	to	to	TO
cord-018265-twp33bb6	368	10	protect	protect	VB
cord-018265-twp33bb6	368	11	them	-PRON-	PRP
cord-018265-twp33bb6	368	12	,	,	,
cord-018265-twp33bb6	368	13	but	but	CC
cord-018265-twp33bb6	368	14	can	can	MD
cord-018265-twp33bb6	368	15	also	also	RB
cord-018265-twp33bb6	368	16	enhance	enhance	VB
cord-018265-twp33bb6	368	17	their	-PRON-	PRP$
cord-018265-twp33bb6	368	18	uptake	uptake	NN
cord-018265-twp33bb6	368	19	,	,	,
cord-018265-twp33bb6	368	20	promote	promote	VB
cord-018265-twp33bb6	368	21	targeting	target	VBG
cord-018265-twp33bb6	368	22	to	to	IN
cord-018265-twp33bb6	368	23	antigen	antigen	NN
cord-018265-twp33bb6	368	24	presenting	present	VBG
cord-018265-twp33bb6	368	25	cells	cell	NNS
cord-018265-twp33bb6	368	26	and	and	CC
cord-018265-twp33bb6	368	27	serve	serve	VBP
cord-018265-twp33bb6	368	28	as	as	IN
cord-018265-twp33bb6	368	29	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	368	30	[	[	-LRB-
cord-018265-twp33bb6	368	31	136	136	CD
cord-018265-twp33bb6	368	32	]	]	-RRB-
cord-018265-twp33bb6	368	33	.	.	.
cord-018265-twp33bb6	369	1	The	the	DT
cord-018265-twp33bb6	369	2	most	most	RBS
cord-018265-twp33bb6	369	3	commonly	commonly	RB
cord-018265-twp33bb6	369	4	exploited	exploit	VBN
cord-018265-twp33bb6	369	5	delivery	delivery	NN
cord-018265-twp33bb6	369	6	systems	system	NNS
cord-018265-twp33bb6	369	7	are	be	VBP
cord-018265-twp33bb6	369	8	:	:	:
cord-018265-twp33bb6	369	9	(	(	-LRB-
cord-018265-twp33bb6	369	10	i	i	NN
cord-018265-twp33bb6	369	11	)	)	-RRB-
cord-018265-twp33bb6	369	12	gelatine	gelatine	NN
cord-018265-twp33bb6	369	13	capsules	capsule	NNS
cord-018265-twp33bb6	369	14	,	,	,
cord-018265-twp33bb6	369	15	which	which	WDT
cord-018265-twp33bb6	369	16	are	be	VBP
cord-018265-twp33bb6	369	17	dissolved	dissolve	VBN
cord-018265-twp33bb6	369	18	at	at	IN
cord-018265-twp33bb6	369	19	alkaline	alkaline	JJ
cord-018265-twp33bb6	369	20	pH	ph	NN
cord-018265-twp33bb6	369	21	in	in	IN
cord-018265-twp33bb6	369	22	the	the	DT
cord-018265-twp33bb6	369	23	intestine	intestine	NN
cord-018265-twp33bb6	369	24	but	but	CC
cord-018265-twp33bb6	369	25	not	not	RB
cord-018265-twp33bb6	369	26	in	in	IN
cord-018265-twp33bb6	369	27	the	the	DT
cord-018265-twp33bb6	369	28	stomach	stomach	NN
cord-018265-twp33bb6	369	29	,	,	,
cord-018265-twp33bb6	369	30	(	(	-LRB-
cord-018265-twp33bb6	369	31	ii	ii	NN
cord-018265-twp33bb6	369	32	)	)	-RRB-
cord-018265-twp33bb6	369	33	muco	muco	NN
cord-018265-twp33bb6	369	34	-	-	HYPH
cord-018265-twp33bb6	369	35	adhesive	adhesive	JJ
cord-018265-twp33bb6	369	36	polymers	polymer	NNS
cord-018265-twp33bb6	369	37	that	that	WDT
cord-018265-twp33bb6	369	38	are	be	VBP
cord-018265-twp33bb6	369	39	highly	highly	RB
cord-018265-twp33bb6	369	40	viscous	viscous	JJ
cord-018265-twp33bb6	369	41	inert	inert	JJ
cord-018265-twp33bb6	369	42	PS	PS	NNP
cord-018265-twp33bb6	369	43	,	,	,
cord-018265-twp33bb6	369	44	(	(	-LRB-
cord-018265-twp33bb6	369	45	iii	iii	NNP
cord-018265-twp33bb6	369	46	)	)	-RRB-
cord-018265-twp33bb6	369	47	eldexomer	eldexomer	NNP
cord-018265-twp33bb6	369	48	and	and	CC
cord-018265-twp33bb6	369	49	carboxymethyl	carboxymethyl	NNP
cord-018265-twp33bb6	369	50	cellulose	cellulose	NN
cord-018265-twp33bb6	369	51	,	,	,
cord-018265-twp33bb6	369	52	which	which	WDT
cord-018265-twp33bb6	369	53	have	have	VBP
cord-018265-twp33bb6	369	54	been	be	VBN
cord-018265-twp33bb6	369	55	used	use	VBN
cord-018265-twp33bb6	369	56	for	for	IN
cord-018265-twp33bb6	369	57	oral	oral	JJ
cord-018265-twp33bb6	369	58	,	,	,
cord-018265-twp33bb6	369	59	nasal	nasal	JJ
cord-018265-twp33bb6	369	60	and	and	CC
cord-018265-twp33bb6	369	61	vaginal	vaginal	JJ
cord-018265-twp33bb6	369	62	delivery	delivery	NN
cord-018265-twp33bb6	369	63	,	,	,
cord-018265-twp33bb6	369	64	(	(	-LRB-
cord-018265-twp33bb6	369	65	iv	iv	LS
cord-018265-twp33bb6	369	66	)	)	-RRB-
cord-018265-twp33bb6	369	67	lipid	lipid	NN
cord-018265-twp33bb6	369	68	-	-	HYPH
cord-018265-twp33bb6	369	69	based	base	VBN
cord-018265-twp33bb6	369	70	structures	structure	NNS
cord-018265-twp33bb6	369	71	with	with	IN
cord-018265-twp33bb6	369	72	entrapped	entrapped	JJ
cord-018265-twp33bb6	369	73	antigens	antigen	NNS
cord-018265-twp33bb6	369	74	,	,	,
cord-018265-twp33bb6	369	75	such	such	JJ
cord-018265-twp33bb6	369	76	as	as	IN
cord-018265-twp33bb6	369	77	immune	immune	JJ
cord-018265-twp33bb6	369	78	stimulating	stimulate	VBG
cord-018265-twp33bb6	369	79	complexes	complex	NNS
cord-018265-twp33bb6	369	80	(	(	-LRB-
cord-018265-twp33bb6	369	81	ISCOMs	iscom	NNS
cord-018265-twp33bb6	369	82	)	)	-RRB-
cord-018265-twp33bb6	369	83	and	and	CC
cord-018265-twp33bb6	369	84	liposomes	liposome	NNS
cord-018265-twp33bb6	369	85	,	,	,
cord-018265-twp33bb6	369	86	and	and	CC
cord-018265-twp33bb6	369	87	(	(	-LRB-
cord-018265-twp33bb6	369	88	v	v	LS
cord-018265-twp33bb6	369	89	)	)	-RRB-
cord-018265-twp33bb6	369	90	biodegradable	biodegradable	JJ
cord-018265-twp33bb6	369	91	micro	micro	NNP
cord-018265-twp33bb6	369	92	/	/	SYM
cord-018265-twp33bb6	369	93	nano	nano	NN
cord-018265-twp33bb6	369	94	-	-	HYPH
cord-018265-twp33bb6	369	95	spheres	sphere	NNS
cord-018265-twp33bb6	369	96	based	base	VBN
cord-018265-twp33bb6	369	97	on	on	IN
cord-018265-twp33bb6	369	98	biocompatible	biocompatible	JJ
cord-018265-twp33bb6	369	99	materials	material	NNS
cord-018265-twp33bb6	369	100	such	such	JJ
cord-018265-twp33bb6	369	101	as	as	IN
cord-018265-twp33bb6	369	102	starch	starch	NN
cord-018265-twp33bb6	369	103	,	,	,
cord-018265-twp33bb6	369	104	copolymers	copolymer	NNS
cord-018265-twp33bb6	369	105	of	of	IN
cord-018265-twp33bb6	369	106	lactic	lactic	JJ
cord-018265-twp33bb6	369	107	or	or	CC
cord-018265-twp33bb6	369	108	glycolic	glycolic	NN
cord-018265-twp33bb6	369	109	acid	acid	NN
cord-018265-twp33bb6	369	110	[	[	-LRB-
cord-018265-twp33bb6	369	111	137	137	CD
cord-018265-twp33bb6	369	112	,	,	,
cord-018265-twp33bb6	369	113	138	138	CD
cord-018265-twp33bb6	369	114	]	]	-RRB-
cord-018265-twp33bb6	369	115	.	.	.
cord-018265-twp33bb6	370	1	Some	some	DT
cord-018265-twp33bb6	370	2	of	of	IN
cord-018265-twp33bb6	370	3	these	these	DT
cord-018265-twp33bb6	370	4	approaches	approach	NNS
cord-018265-twp33bb6	370	5	are	be	VBP
cord-018265-twp33bb6	370	6	currently	currently	RB
cord-018265-twp33bb6	370	7	being	be	VBG
cord-018265-twp33bb6	370	8	explored	explore	VBN
cord-018265-twp33bb6	370	9	to	to	TO
cord-018265-twp33bb6	370	10	develop	develop	VB
cord-018265-twp33bb6	370	11	vaccines	vaccine	NNS
cord-018265-twp33bb6	370	12	against	against	IN
cord-018265-twp33bb6	370	13	agents	agent	NNS
cord-018265-twp33bb6	370	14	causing	cause	VBG
cord-018265-twp33bb6	370	15	community	community	NN
cord-018265-twp33bb6	370	16	-	-	HYPH
cord-018265-twp33bb6	370	17	acquired	acquire	VBN
cord-018265-twp33bb6	370	18	pneumonia	pneumonia	NN
cord-018265-twp33bb6	370	19	.	.	.
cord-018265-twp33bb6	371	1	Encouraging	encourage	VBG
cord-018265-twp33bb6	371	2	results	result	NNS
cord-018265-twp33bb6	371	3	have	have	VBP
cord-018265-twp33bb6	371	4	been	be	VBN
cord-018265-twp33bb6	371	5	obtained	obtain	VBN
cord-018265-twp33bb6	371	6	,	,	,
cord-018265-twp33bb6	371	7	among	among	IN
cord-018265-twp33bb6	371	8	others	other	NNS
cord-018265-twp33bb6	371	9	,	,	,
cord-018265-twp33bb6	371	10	using	use	VBG
cord-018265-twp33bb6	371	11	surface	surface	NN
cord-018265-twp33bb6	371	12	antigens	antigen	NNS
cord-018265-twp33bb6	371	13	from	from	IN
cord-018265-twp33bb6	371	14	S.	S.	NNP
cord-018265-twp33bb6	371	15	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	371	16	encapsulated	encapsulate	VBN
cord-018265-twp33bb6	371	17	in	in	IN
cord-018265-twp33bb6	371	18	micro	micro	NNS
cord-018265-twp33bb6	371	19	-	-	NNS
cord-018265-twp33bb6	371	20	spheres	sphere	NNS
cord-018265-twp33bb6	371	21	[	[	-LRB-
cord-018265-twp33bb6	371	22	139	139	CD
cord-018265-twp33bb6	371	23	]	]	-RRB-
cord-018265-twp33bb6	371	24	and	and	CC
cord-018265-twp33bb6	371	25	a	a	DT
cord-018265-twp33bb6	371	26	ISCOM	ISCOM	NNP
cord-018265-twp33bb6	371	27	-	-	HYPH
cord-018265-twp33bb6	371	28	adjuvanted	adjuvante	VBN
cord-018265-twp33bb6	371	29	vaccine	vaccine	NN
cord-018265-twp33bb6	371	30	obtained	obtain	VBN
cord-018265-twp33bb6	371	31	by	by	IN
cord-018265-twp33bb6	371	32	reverse	reverse	JJ
cord-018265-twp33bb6	371	33	genetics	genetic	NNS
cord-018265-twp33bb6	371	34	against	against	IN
cord-018265-twp33bb6	371	35	the	the	DT
cord-018265-twp33bb6	371	36	influenza	influenza	NN
cord-018265-twp33bb6	371	37	virus	virus	NN
cord-018265-twp33bb6	371	38	,	,	,
cord-018265-twp33bb6	371	39	in	in	IN
cord-018265-twp33bb6	371	40	preclinical	preclinical	JJ
cord-018265-twp33bb6	371	41	models	model	NNS
cord-018265-twp33bb6	371	42	[	[	-LRB-
cord-018265-twp33bb6	371	43	140	140	CD
cord-018265-twp33bb6	371	44	]	]	-RRB-
cord-018265-twp33bb6	371	45	.	.	.
cord-018265-twp33bb6	372	1	Attenuated	attenuated	JJ
cord-018265-twp33bb6	372	2	viruses	virus	NNS
cord-018265-twp33bb6	372	3	and	and	CC
cord-018265-twp33bb6	372	4	bacteria	bacteria	NNS
cord-018265-twp33bb6	372	5	can	can	MD
cord-018265-twp33bb6	372	6	be	be	VB
cord-018265-twp33bb6	372	7	used	use	VBN
cord-018265-twp33bb6	372	8	not	not	RB
cord-018265-twp33bb6	372	9	only	only	RB
cord-018265-twp33bb6	372	10	as	as	IN
cord-018265-twp33bb6	372	11	vaccine	vaccine	NN
cord-018265-twp33bb6	372	12	candidates	candidate	NNS
cord-018265-twp33bb6	372	13	per	per	IN
cord-018265-twp33bb6	372	14	se	se	FW
cord-018265-twp33bb6	372	15	,	,	,
cord-018265-twp33bb6	372	16	but	but	CC
cord-018265-twp33bb6	372	17	also	also	RB
cord-018265-twp33bb6	372	18	as	as	IN
cord-018265-twp33bb6	372	19	delivery	delivery	NN
cord-018265-twp33bb6	372	20	systems	system	NNS
cord-018265-twp33bb6	372	21	for	for	IN
cord-018265-twp33bb6	372	22	heterologous	heterologous	JJ
cord-018265-twp33bb6	372	23	antigens	antigen	NNS
cord-018265-twp33bb6	372	24	.	.	.
cord-018265-twp33bb6	373	1	Thus	thus	RB
cord-018265-twp33bb6	373	2	,	,	,
cord-018265-twp33bb6	373	3	many	many	JJ
cord-018265-twp33bb6	373	4	attenuated	attenuated	JJ
cord-018265-twp33bb6	373	5	microorganisms	microorganism	NNS
cord-018265-twp33bb6	373	6	have	have	VBP
cord-018265-twp33bb6	373	7	been	be	VBN
cord-018265-twp33bb6	373	8	exploited	exploit	VBN
cord-018265-twp33bb6	373	9	as	as	IN
cord-018265-twp33bb6	373	10	a	a	DT
cord-018265-twp33bb6	373	11	scaffold	scaffold	NN
cord-018265-twp33bb6	373	12	for	for	IN
cord-018265-twp33bb6	373	13	the	the	DT
cord-018265-twp33bb6	373	14	development	development	NN
cord-018265-twp33bb6	373	15	of	of	IN
cord-018265-twp33bb6	373	16	subunit	subunit	NN
cord-018265-twp33bb6	373	17	vaccines	vaccine	NNS
cord-018265-twp33bb6	373	18	against	against	IN
cord-018265-twp33bb6	373	19	other	other	JJ
cord-018265-twp33bb6	373	20	agents	agent	NNS
cord-018265-twp33bb6	373	21	,	,	,
cord-018265-twp33bb6	373	22	under	under	IN
cord-018265-twp33bb6	373	23	the	the	DT
cord-018265-twp33bb6	373	24	premise	premise	NN
cord-018265-twp33bb6	373	25	that	that	IN
cord-018265-twp33bb6	373	26	the	the	DT
cord-018265-twp33bb6	373	27	expression	expression	NN
cord-018265-twp33bb6	373	28	of	of	IN
cord-018265-twp33bb6	373	29	the	the	DT
cord-018265-twp33bb6	373	30	recombinant	recombinant	JJ
cord-018265-twp33bb6	373	31	antigen(s	antigen(s	NNP
cord-018265-twp33bb6	373	32	)	)	-RRB-
cord-018265-twp33bb6	373	33	does	do	VBZ
cord-018265-twp33bb6	373	34	not	not	RB
cord-018265-twp33bb6	373	35	increase	increase	VB
cord-018265-twp33bb6	373	36	their	-PRON-	PRP$
cord-018265-twp33bb6	373	37	pathogenic	pathogenic	JJ
cord-018265-twp33bb6	373	38	potential	potential	NN
cord-018265-twp33bb6	373	39	for	for	IN
cord-018265-twp33bb6	373	40	humans	human	NNS
cord-018265-twp33bb6	373	41	or	or	CC
cord-018265-twp33bb6	373	42	animals	animal	NNS
cord-018265-twp33bb6	373	43	.	.	.
cord-018265-twp33bb6	374	1	The	the	DT
cord-018265-twp33bb6	374	2	most	most	RBS
cord-018265-twp33bb6	374	3	frequently	frequently	RB
cord-018265-twp33bb6	374	4	exploited	exploit	VBN
cord-018265-twp33bb6	374	5	bacterial	bacterial	JJ
cord-018265-twp33bb6	374	6	vectors	vector	NNS
cord-018265-twp33bb6	374	7	are	be	VBP
cord-018265-twp33bb6	374	8	attenuated	attenuated	JJ
cord-018265-twp33bb6	374	9	derivatives	derivative	NNS
cord-018265-twp33bb6	374	10	of	of	IN
cord-018265-twp33bb6	374	11	Salmonella	Salmonella	NNP
cord-018265-twp33bb6	374	12	enterica	enterica	NNP
cord-018265-twp33bb6	374	13	and	and	CC
cord-018265-twp33bb6	374	14	Shigella	Shigella	NNP
cord-018265-twp33bb6	374	15	spp	spp	NNS
cord-018265-twp33bb6	374	16	.	.	.
cord-018265-twp33bb6	375	1	,	,	,
cord-018265-twp33bb6	375	2	and	and	CC
cord-018265-twp33bb6	375	3	the	the	DT
cord-018265-twp33bb6	375	4	Bacille	Bacille	NNP
cord-018265-twp33bb6	375	5	Calmette	Calmette	NNP
cord-018265-twp33bb6	375	6	-	-	HYPH
cord-018265-twp33bb6	375	7	Guérin	Guérin	NNP
cord-018265-twp33bb6	375	8	(	(	-LRB-
cord-018265-twp33bb6	375	9	BCG	BCG	NNP
cord-018265-twp33bb6	375	10	)	)	-RRB-
cord-018265-twp33bb6	375	11	.	.	.
cord-018265-twp33bb6	376	1	For	for	IN
cord-018265-twp33bb6	376	2	example	example	NN
cord-018265-twp33bb6	376	3	,	,	,
cord-018265-twp33bb6	376	4	vaccination	vaccination	NN
cord-018265-twp33bb6	376	5	with	with	IN
cord-018265-twp33bb6	376	6	an	an	DT
cord-018265-twp33bb6	376	7	attenuated	attenuated	JJ
cord-018265-twp33bb6	376	8	Salmonella	Salmonella	NNP
cord-018265-twp33bb6	376	9	expressing	express	VBG
cord-018265-twp33bb6	376	10	the	the	DT
cord-018265-twp33bb6	376	11	OprF	OprF	NNP
cord-018265-twp33bb6	376	12	-	-	HYPH
cord-018265-twp33bb6	376	13	OprI	OprI	NNP
cord-018265-twp33bb6	376	14	was	be	VBD
cord-018265-twp33bb6	376	15	also	also	RB
cord-018265-twp33bb6	376	16	shown	show	VBN
cord-018265-twp33bb6	376	17	to	to	TO
cord-018265-twp33bb6	376	18	be	be	VB
cord-018265-twp33bb6	376	19	able	able	JJ
cord-018265-twp33bb6	376	20	to	to	TO
cord-018265-twp33bb6	376	21	confer	confer	VB
cord-018265-twp33bb6	376	22	protection	protection	NN
cord-018265-twp33bb6	376	23	against	against	IN
cord-018265-twp33bb6	376	24	P.	P.	NNP
cord-018265-twp33bb6	376	25	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	376	26	in	in	IN
cord-018265-twp33bb6	376	27	a	a	DT
cord-018265-twp33bb6	376	28	murine	murine	JJ
cord-018265-twp33bb6	376	29	experimental	experimental	JJ
cord-018265-twp33bb6	376	30	infection	infection	NN
cord-018265-twp33bb6	376	31	model	model	NN
cord-018265-twp33bb6	376	32	[	[	-LRB-
cord-018265-twp33bb6	376	33	141	141	CD
cord-018265-twp33bb6	376	34	]	]	-RRB-
cord-018265-twp33bb6	376	35	.	.	.
cord-018265-twp33bb6	377	1	In	in	IN
cord-018265-twp33bb6	377	2	addition	addition	NN
cord-018265-twp33bb6	377	3	,	,	,
cord-018265-twp33bb6	377	4	it	-PRON-	PRP
cord-018265-twp33bb6	377	5	was	be	VBD
cord-018265-twp33bb6	377	6	also	also	RB
cord-018265-twp33bb6	377	7	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	377	8	that	that	IN
cord-018265-twp33bb6	377	9	a	a	DT
cord-018265-twp33bb6	377	10	recombinant	recombinant	JJ
cord-018265-twp33bb6	377	11	BCGbased	bcgbased	JJ
cord-018265-twp33bb6	377	12	vaccine	vaccine	NN
cord-018265-twp33bb6	377	13	expressing	express	VBG
cord-018265-twp33bb6	377	14	the	the	DT
cord-018265-twp33bb6	377	15	PspA	PspA	NNP
cord-018265-twp33bb6	377	16	confers	confer	VBZ
cord-018265-twp33bb6	377	17	protection	protection	NN
cord-018265-twp33bb6	377	18	against	against	IN
cord-018265-twp33bb6	377	19	S.	S.	NNP
cord-018265-twp33bb6	377	20	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	377	21	in	in	IN
cord-018265-twp33bb6	377	22	an	an	DT
cord-018265-twp33bb6	377	23	infection	infection	NN
cord-018265-twp33bb6	377	24	animal	animal	NN
cord-018265-twp33bb6	377	25	model	model	NN
cord-018265-twp33bb6	377	26	[	[	-LRB-
cord-018265-twp33bb6	377	27	142	142	CD
cord-018265-twp33bb6	377	28	]	]	-RRB-
cord-018265-twp33bb6	377	29	.	.	.
cord-018265-twp33bb6	378	1	The	the	DT
cord-018265-twp33bb6	378	2	use	use	NN
cord-018265-twp33bb6	378	3	of	of	IN
cord-018265-twp33bb6	378	4	commensals	commensal	NNS
cord-018265-twp33bb6	378	5	represents	represent	VBZ
cord-018265-twp33bb6	378	6	an	an	DT
cord-018265-twp33bb6	378	7	alternative	alternative	NN
cord-018265-twp33bb6	378	8	to	to	IN
cord-018265-twp33bb6	378	9	attenuated	attenuated	JJ
cord-018265-twp33bb6	378	10	organisms	organism	NNS
cord-018265-twp33bb6	378	11	(	(	-LRB-
cord-018265-twp33bb6	378	12	e.g.	e.g.	RB
cord-018265-twp33bb6	378	13	,	,	,
cord-018265-twp33bb6	378	14	lactobacilli	lactobacilli	NN
cord-018265-twp33bb6	378	15	)	)	-RRB-
cord-018265-twp33bb6	378	16	.	.	.
cord-018265-twp33bb6	379	1	In	in	IN
cord-018265-twp33bb6	379	2	this	this	DT
cord-018265-twp33bb6	379	3	context	context	NN
cord-018265-twp33bb6	379	4	it	-PRON-	PRP
cord-018265-twp33bb6	379	5	was	be	VBD
cord-018265-twp33bb6	379	6	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	379	7	that	that	IN
cord-018265-twp33bb6	379	8	oral	oral	JJ
cord-018265-twp33bb6	379	9	administration	administration	NN
cord-018265-twp33bb6	379	10	of	of	IN
cord-018265-twp33bb6	379	11	Lactobacillus	Lactobacillus	NNP
cord-018265-twp33bb6	379	12	expressing	express	VBG
cord-018265-twp33bb6	379	13	proteins	protein	NNS
cord-018265-twp33bb6	379	14	from	from	IN
cord-018265-twp33bb6	379	15	coronavirus	coronavirus	NN
cord-018265-twp33bb6	379	16	can	can	MD
cord-018265-twp33bb6	379	17	protect	protect	VB
cord-018265-twp33bb6	379	18	against	against	IN
cord-018265-twp33bb6	379	19	a	a	DT
cord-018265-twp33bb6	379	20	gastric	gastric	JJ
cord-018265-twp33bb6	379	21	infection	infection	NN
cord-018265-twp33bb6	379	22	[	[	-LRB-
cord-018265-twp33bb6	379	23	143	143	CD
cord-018265-twp33bb6	379	24	]	]	-RRB-
cord-018265-twp33bb6	379	25	.	.	.
cord-018265-twp33bb6	380	1	Thus	thus	RB
cord-018265-twp33bb6	380	2	,	,	,
cord-018265-twp33bb6	380	3	this	this	DT
cord-018265-twp33bb6	380	4	approach	approach	NN
cord-018265-twp33bb6	380	5	has	have	VBZ
cord-018265-twp33bb6	380	6	been	be	VBN
cord-018265-twp33bb6	380	7	also	also	RB
cord-018265-twp33bb6	380	8	proposed	propose	VBN
cord-018265-twp33bb6	380	9	to	to	TO
cord-018265-twp33bb6	380	10	combat	combat	VB
cord-018265-twp33bb6	380	11	SARS	SARS	NNP
cord-018265-twp33bb6	380	12	.	.	.
cord-018265-twp33bb6	381	1	Promising	promising	JJ
cord-018265-twp33bb6	381	2	results	result	NNS
cord-018265-twp33bb6	381	3	were	be	VBD
cord-018265-twp33bb6	381	4	also	also	RB
cord-018265-twp33bb6	381	5	obtained	obtain	VBN
cord-018265-twp33bb6	381	6	using	use	VBG
cord-018265-twp33bb6	381	7	x	x	SYM
cord-018265-twp33bb6	381	8	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	381	9	psittaci	psittaci	NN
cord-018265-twp33bb6	381	10	[	[	-LRB-
cord-018265-twp33bb6	381	11	144	144	CD
cord-018265-twp33bb6	381	12	]	]	-RRB-
cord-018265-twp33bb6	381	13	.	.	.
cord-018265-twp33bb6	382	1	On	on	IN
cord-018265-twp33bb6	382	2	the	the	DT
cord-018265-twp33bb6	382	3	other	other	JJ
cord-018265-twp33bb6	382	4	hand	hand	NN
cord-018265-twp33bb6	382	5	,	,	,
cord-018265-twp33bb6	382	6	different	different	JJ
cord-018265-twp33bb6	382	7	attenuated	attenuated	JJ
cord-018265-twp33bb6	382	8	viruses	virus	NNS
cord-018265-twp33bb6	382	9	,	,	,
cord-018265-twp33bb6	382	10	such	such	JJ
cord-018265-twp33bb6	382	11	as	as	IN
cord-018265-twp33bb6	382	12	MVA	MVA	NNP
cord-018265-twp33bb6	382	13	,	,	,
cord-018265-twp33bb6	382	14	bovine	bovine	JJ
cord-018265-twp33bb6	382	15	or	or	CC
cord-018265-twp33bb6	382	16	attenuated	attenuated	JJ
cord-018265-twp33bb6	382	17	hPIV-3	hpiv-3	NN
cord-018265-twp33bb6	382	18	and	and	CC
cord-018265-twp33bb6	382	19	adenovirus	adenovirus	NN
cord-018265-twp33bb6	382	20	can	can	MD
cord-018265-twp33bb6	382	21	be	be	VB
cord-018265-twp33bb6	382	22	used	use	VBN
cord-018265-twp33bb6	382	23	as	as	IN
cord-018265-twp33bb6	382	24	delivery	delivery	NN
cord-018265-twp33bb6	382	25	systems	system	NNS
cord-018265-twp33bb6	382	26	for	for	IN
cord-018265-twp33bb6	382	27	heterologous	heterologous	JJ
cord-018265-twp33bb6	382	28	antigens	antigen	NNS
cord-018265-twp33bb6	382	29	[	[	-LRB-
cord-018265-twp33bb6	382	30	25	25	CD
cord-018265-twp33bb6	382	31	,	,	,
cord-018265-twp33bb6	382	32	145	145	CD
cord-018265-twp33bb6	382	33	]	]	-RRB-
cord-018265-twp33bb6	382	34	.	.	.
cord-018265-twp33bb6	383	1	In	in	IN
cord-018265-twp33bb6	383	2	fact	fact	NN
cord-018265-twp33bb6	383	3	,	,	,
cord-018265-twp33bb6	383	4	MVA	MVA	NNP
cord-018265-twp33bb6	383	5	has	have	VBZ
cord-018265-twp33bb6	383	6	recently	recently	RB
cord-018265-twp33bb6	383	7	been	be	VBN
cord-018265-twp33bb6	383	8	exploited	exploit	VBN
cord-018265-twp33bb6	383	9	for	for	IN
cord-018265-twp33bb6	383	10	antigens	antigen	NNS
cord-018265-twp33bb6	383	11	of	of	IN
cord-018265-twp33bb6	383	12	the	the	DT
cord-018265-twp33bb6	383	13	SARS	SARS	NNP
cord-018265-twp33bb6	383	14	associated	associate	VBD
cord-018265-twp33bb6	383	15	coronavirus	coronavirus	NN
cord-018265-twp33bb6	383	16	[	[	-LRB-
cord-018265-twp33bb6	383	17	146	146	CD
cord-018265-twp33bb6	383	18	]	]	-RRB-
cord-018265-twp33bb6	383	19	.	.	.
cord-018265-twp33bb6	384	1	An	an	DT
cord-018265-twp33bb6	384	2	alternative	alternative	JJ
cord-018265-twp33bb6	384	3	approach	approach	NN
cord-018265-twp33bb6	384	4	to	to	IN
cord-018265-twp33bb6	384	5	the	the	DT
cord-018265-twp33bb6	384	6	use	use	NN
cord-018265-twp33bb6	384	7	of	of	IN
cord-018265-twp33bb6	384	8	live	live	JJ
cord-018265-twp33bb6	384	9	attenuated	attenuated	JJ
cord-018265-twp33bb6	384	10	carriers	carrier	NNS
cord-018265-twp33bb6	384	11	is	be	VBZ
cord-018265-twp33bb6	384	12	given	give	VBN
cord-018265-twp33bb6	384	13	by	by	IN
cord-018265-twp33bb6	384	14	the	the	DT
cord-018265-twp33bb6	384	15	use	use	NN
cord-018265-twp33bb6	384	16	of	of	IN
cord-018265-twp33bb6	384	17	bacterial	bacterial	JJ
cord-018265-twp33bb6	384	18	ghosts	ghost	NNS
cord-018265-twp33bb6	384	19	.	.	.
cord-018265-twp33bb6	385	1	Ghosts	ghost	NNS
cord-018265-twp33bb6	385	2	are	be	VBP
cord-018265-twp33bb6	385	3	generated	generate	VBN
cord-018265-twp33bb6	385	4	by	by	IN
cord-018265-twp33bb6	385	5	the	the	DT
cord-018265-twp33bb6	385	6	conditional	conditional	JJ
cord-018265-twp33bb6	385	7	expression	expression	NN
cord-018265-twp33bb6	385	8	of	of	IN
cord-018265-twp33bb6	385	9	the	the	DT
cord-018265-twp33bb6	385	10	lethal	lethal	JJ
cord-018265-twp33bb6	385	11	lysis	lysis	NN
cord-018265-twp33bb6	385	12	gene	gene	NN
cord-018265-twp33bb6	385	13	E	e	NN
cord-018265-twp33bb6	385	14	from	from	IN
cord-018265-twp33bb6	385	15	bacteriophage	bacteriophage	NN
cord-018265-twp33bb6	385	16	PhiX174	PhiX174	NNP
cord-018265-twp33bb6	385	17	in	in	IN
cord-018265-twp33bb6	385	18	Gram	gram	NN
cord-018265-twp33bb6	385	19	-	-	HYPH
cord-018265-twp33bb6	385	20	negative	negative	JJ
cord-018265-twp33bb6	385	21	bacteria	bacteria	NNS
cord-018265-twp33bb6	385	22	[	[	-LRB-
cord-018265-twp33bb6	385	23	147	147	CD
cord-018265-twp33bb6	385	24	]	]	-RRB-
cord-018265-twp33bb6	385	25	[	[	-LRB-
cord-018265-twp33bb6	385	26	148	148	CD
cord-018265-twp33bb6	385	27	]	]	-RRB-
cord-018265-twp33bb6	385	28	[	[	-LRB-
cord-018265-twp33bb6	385	29	149	149	CD
cord-018265-twp33bb6	385	30	]	]	-RRB-
cord-018265-twp33bb6	385	31	[	[	-LRB-
cord-018265-twp33bb6	385	32	150	150	CD
cord-018265-twp33bb6	385	33	]	]	-RRB-
cord-018265-twp33bb6	385	34	[	[	-LRB-
cord-018265-twp33bb6	385	35	151	151	CD
cord-018265-twp33bb6	385	36	]	]	-RRB-
cord-018265-twp33bb6	385	37	.	.	.
cord-018265-twp33bb6	386	1	This	this	DT
cord-018265-twp33bb6	386	2	leads	lead	VBZ
cord-018265-twp33bb6	386	3	to	to	IN
cord-018265-twp33bb6	386	4	the	the	DT
cord-018265-twp33bb6	386	5	formation	formation	NN
cord-018265-twp33bb6	386	6	of	of	IN
cord-018265-twp33bb6	386	7	a	a	DT
cord-018265-twp33bb6	386	8	trans	trans	NN
cord-018265-twp33bb6	386	9	-	-	NN
cord-018265-twp33bb6	386	10	membrane	membrane	NN
cord-018265-twp33bb6	386	11	tunnel	tunnel	NN
cord-018265-twp33bb6	386	12	through	through	IN
cord-018265-twp33bb6	386	13	the	the	DT
cord-018265-twp33bb6	386	14	bacterial	bacterial	JJ
cord-018265-twp33bb6	386	15	cellular	cellular	JJ
cord-018265-twp33bb6	386	16	envelope	envelope	NN
cord-018265-twp33bb6	386	17	[	[	-LRB-
cord-018265-twp33bb6	386	18	147	147	CD
cord-018265-twp33bb6	386	19	]	]	-RRB-
cord-018265-twp33bb6	386	20	.	.	.
cord-018265-twp33bb6	387	1	Due	due	IN
cord-018265-twp33bb6	387	2	to	to	IN
cord-018265-twp33bb6	387	3	the	the	DT
cord-018265-twp33bb6	387	4	high	high	JJ
cord-018265-twp33bb6	387	5	internal	internal	JJ
cord-018265-twp33bb6	387	6	osmotic	osmotic	JJ
cord-018265-twp33bb6	387	7	pressure	pressure	NN
cord-018265-twp33bb6	387	8	,	,	,
cord-018265-twp33bb6	387	9	the	the	DT
cord-018265-twp33bb6	387	10	cytoplasm	cytoplasm	NN
cord-018265-twp33bb6	387	11	content	content	NN
cord-018265-twp33bb6	387	12	is	be	VBZ
cord-018265-twp33bb6	387	13	expelled	expel	VBN
cord-018265-twp33bb6	387	14	through	through	IN
cord-018265-twp33bb6	387	15	the	the	DT
cord-018265-twp33bb6	387	16	tunnel	tunnel	NN
cord-018265-twp33bb6	387	17	,	,	,
cord-018265-twp33bb6	387	18	thereby	thereby	RB
cord-018265-twp33bb6	387	19	leading	lead	VBG
cord-018265-twp33bb6	387	20	to	to	IN
cord-018265-twp33bb6	387	21	an	an	DT
cord-018265-twp33bb6	387	22	empty	empty	JJ
cord-018265-twp33bb6	387	23	bacterial	bacterial	JJ
cord-018265-twp33bb6	387	24	cell	cell	NN
cord-018265-twp33bb6	387	25	envelope	envelope	NN
cord-018265-twp33bb6	387	26	[	[	-LRB-
cord-018265-twp33bb6	387	27	152	152	CD
cord-018265-twp33bb6	387	28	]	]	-RRB-
cord-018265-twp33bb6	387	29	.	.	.
cord-018265-twp33bb6	388	1	The	the	DT
cord-018265-twp33bb6	388	2	presence	presence	NN
cord-018265-twp33bb6	388	3	of	of	IN
cord-018265-twp33bb6	388	4	envelope	envelope	NN
cord-018265-twp33bb6	388	5	components	component	NNS
cord-018265-twp33bb6	388	6	in	in	IN
cord-018265-twp33bb6	388	7	the	the	DT
cord-018265-twp33bb6	388	8	ghosts	ghost	NNS
cord-018265-twp33bb6	388	9	provides	provide	VBZ
cord-018265-twp33bb6	388	10	a	a	DT
cord-018265-twp33bb6	388	11	strong	strong	JJ
cord-018265-twp33bb6	388	12	danger	danger	NN
cord-018265-twp33bb6	388	13	signal	signal	NN
cord-018265-twp33bb6	388	14	through	through	IN
cord-018265-twp33bb6	388	15	the	the	DT
cord-018265-twp33bb6	388	16	activation	activation	NN
cord-018265-twp33bb6	388	17	of	of	IN
cord-018265-twp33bb6	388	18	pattern	pattern	NN
cord-018265-twp33bb6	388	19	recognition	recognition	NN
cord-018265-twp33bb6	388	20	receptors	receptor	NNS
cord-018265-twp33bb6	388	21	[	[	-LRB-
cord-018265-twp33bb6	388	22	153	153	CD
cord-018265-twp33bb6	388	23	]	]	-RRB-
cord-018265-twp33bb6	388	24	.	.	.
cord-018265-twp33bb6	389	1	In	in	IN
cord-018265-twp33bb6	389	2	addition	addition	NN
cord-018265-twp33bb6	389	3	,	,	,
cord-018265-twp33bb6	389	4	bacterial	bacterial	JJ
cord-018265-twp33bb6	389	5	ghosts	ghost	NNS
cord-018265-twp33bb6	389	6	are	be	VBP
cord-018265-twp33bb6	389	7	efficiently	efficiently	RB
cord-018265-twp33bb6	389	8	taken	take	VBN
cord-018265-twp33bb6	389	9	up	up	RP
cord-018265-twp33bb6	389	10	by	by	IN
cord-018265-twp33bb6	389	11	antigen	antigen	NN
cord-018265-twp33bb6	389	12	-	-	HYPH
cord-018265-twp33bb6	389	13	presenting	present	VBG
cord-018265-twp33bb6	389	14	cells	cell	NNS
cord-018265-twp33bb6	389	15	,	,	,
cord-018265-twp33bb6	389	16	stimulating	stimulate	VBG
cord-018265-twp33bb6	389	17	their	-PRON-	PRP$
cord-018265-twp33bb6	389	18	maturation	maturation	NN
cord-018265-twp33bb6	389	19	and	and	CC
cord-018265-twp33bb6	389	20	activation	activation	NN
cord-018265-twp33bb6	389	21	[	[	-LRB-
cord-018265-twp33bb6	389	22	154	154	CD
cord-018265-twp33bb6	389	23	]	]	-RRB-
cord-018265-twp33bb6	389	24	.	.	.
cord-018265-twp33bb6	390	1	Bacterial	bacterial	JJ
cord-018265-twp33bb6	390	2	ghosts	ghost	NNS
cord-018265-twp33bb6	390	3	retain	retain	VBP
cord-018265-twp33bb6	390	4	all	all	DT
cord-018265-twp33bb6	390	5	morphological	morphological	JJ
cord-018265-twp33bb6	390	6	,	,	,
cord-018265-twp33bb6	390	7	structural	structural	JJ
cord-018265-twp33bb6	390	8	,	,	,
cord-018265-twp33bb6	390	9	and	and	CC
cord-018265-twp33bb6	390	10	antigenic	antigenic	JJ
cord-018265-twp33bb6	390	11	features	feature	NNS
cord-018265-twp33bb6	390	12	of	of	IN
cord-018265-twp33bb6	390	13	the	the	DT
cord-018265-twp33bb6	390	14	cell	cell	NN
cord-018265-twp33bb6	390	15	wall	wall	NN
cord-018265-twp33bb6	390	16	and	and	CC
cord-018265-twp33bb6	390	17	can	can	MD
cord-018265-twp33bb6	390	18	be	be	VB
cord-018265-twp33bb6	390	19	used	use	VBN
cord-018265-twp33bb6	390	20	as	as	IN
cord-018265-twp33bb6	390	21	vaccine	vaccine	NN
cord-018265-twp33bb6	390	22	candidates	candidate	NNS
cord-018265-twp33bb6	390	23	per	per	FW
cord-018265-twp33bb6	390	24	se	se	FW
cord-018265-twp33bb6	390	25	.	.	.
cord-018265-twp33bb6	391	1	Ghosts	ghost	NNS
cord-018265-twp33bb6	391	2	can	can	MD
cord-018265-twp33bb6	391	3	also	also	RB
cord-018265-twp33bb6	391	4	be	be	VB
cord-018265-twp33bb6	391	5	externally	externally	RB
cord-018265-twp33bb6	391	6	loaded	load	VBN
cord-018265-twp33bb6	391	7	with	with	IN
cord-018265-twp33bb6	391	8	purified	purify	VBN
cord-018265-twp33bb6	391	9	antigens	antigen	NNS
cord-018265-twp33bb6	391	10	.	.	.
cord-018265-twp33bb6	392	1	Alternatively	alternatively	RB
cord-018265-twp33bb6	392	2	,	,	,
cord-018265-twp33bb6	392	3	ghosts	ghost	NNS
cord-018265-twp33bb6	392	4	can	can	MD
cord-018265-twp33bb6	392	5	be	be	VB
cord-018265-twp33bb6	392	6	generated	generate	VBN
cord-018265-twp33bb6	392	7	from	from	IN
cord-018265-twp33bb6	392	8	recombinant	recombinant	JJ
cord-018265-twp33bb6	392	9	bacteria	bacteria	NNS
cord-018265-twp33bb6	392	10	expressing	express	VBG
cord-018265-twp33bb6	392	11	heterologous	heterologous	JJ
cord-018265-twp33bb6	392	12	antigens	antigen	NNS
cord-018265-twp33bb6	392	13	,	,	,
cord-018265-twp33bb6	392	14	hence	hence	RB
cord-018265-twp33bb6	392	15	avoiding	avoid	VBG
cord-018265-twp33bb6	392	16	the	the	DT
cord-018265-twp33bb6	392	17	difficulties	difficulty	NNS
cord-018265-twp33bb6	392	18	associated	associate	VBN
cord-018265-twp33bb6	392	19	with	with	IN
cord-018265-twp33bb6	392	20	the	the	DT
cord-018265-twp33bb6	392	21	purification	purification	NN
cord-018265-twp33bb6	392	22	steps	step	NNS
cord-018265-twp33bb6	392	23	.	.	.
cord-018265-twp33bb6	393	1	This	this	DT
cord-018265-twp33bb6	393	2	technology	technology	NN
cord-018265-twp33bb6	393	3	also	also	RB
cord-018265-twp33bb6	393	4	offers	offer	VBZ
cord-018265-twp33bb6	393	5	the	the	DT
cord-018265-twp33bb6	393	6	possibility	possibility	NN
cord-018265-twp33bb6	393	7	to	to	TO
cord-018265-twp33bb6	393	8	manipulate	manipulate	VB
cord-018265-twp33bb6	393	9	the	the	DT
cord-018265-twp33bb6	393	10	topology	topology	NN
cord-018265-twp33bb6	393	11	of	of	IN
cord-018265-twp33bb6	393	12	the	the	DT
cord-018265-twp33bb6	393	13	recombinant	recombinant	JJ
cord-018265-twp33bb6	393	14	antigen	antigen	NN
cord-018265-twp33bb6	393	15	(	(	-LRB-
cord-018265-twp33bb6	393	16	e.g.	e.g.	RB
cord-018265-twp33bb6	393	17	,	,	,
cord-018265-twp33bb6	393	18	the	the	DT
cord-018265-twp33bb6	393	19	antigen	antigen	NN
cord-018265-twp33bb6	393	20	can	can	MD
cord-018265-twp33bb6	393	21	be	be	VB
cord-018265-twp33bb6	393	22	bound	bind	VBN
cord-018265-twp33bb6	393	23	to	to	IN
cord-018265-twp33bb6	393	24	the	the	DT
cord-018265-twp33bb6	393	25	inner	inner	JJ
cord-018265-twp33bb6	393	26	membrane	membrane	NN
cord-018265-twp33bb6	393	27	,	,	,
cord-018265-twp33bb6	393	28	secreted	secrete	VBN
cord-018265-twp33bb6	393	29	into	into	IN
cord-018265-twp33bb6	393	30	the	the	DT
cord-018265-twp33bb6	393	31	periplasmic	periplasmic	JJ
cord-018265-twp33bb6	393	32	space	space	NN
cord-018265-twp33bb6	393	33	or	or	CC
cord-018265-twp33bb6	393	34	associated	associate	VBN
cord-018265-twp33bb6	393	35	to	to	IN
cord-018265-twp33bb6	393	36	the	the	DT
cord-018265-twp33bb6	393	37	surface	surface	NN
cord-018265-twp33bb6	393	38	)	)	-RRB-
cord-018265-twp33bb6	393	39	.	.	.
cord-018265-twp33bb6	394	1	Encouraging	encourage	VBG
cord-018265-twp33bb6	394	2	results	result	NNS
cord-018265-twp33bb6	394	3	has	have	VBZ
cord-018265-twp33bb6	394	4	been	be	VBN
cord-018265-twp33bb6	394	5	obtained	obtain	VBN
cord-018265-twp33bb6	394	6	in	in	IN
cord-018265-twp33bb6	394	7	preclinical	preclinical	JJ
cord-018265-twp33bb6	394	8	models	model	NNS
cord-018265-twp33bb6	394	9	using	use	VBG
cord-018265-twp33bb6	394	10	ghosts	ghost	NNS
cord-018265-twp33bb6	394	11	expressing	express	VBG
cord-018265-twp33bb6	394	12	chlamydial	chlamydial	JJ
cord-018265-twp33bb6	394	13	antigens	antigen	NNS
cord-018265-twp33bb6	394	14	[	[	-LRB-
cord-018265-twp33bb6	394	15	135	135	CD
cord-018265-twp33bb6	394	16	,	,	,
cord-018265-twp33bb6	394	17	155	155	CD
cord-018265-twp33bb6	394	18	]	]	-RRB-
cord-018265-twp33bb6	394	19	.	.	.
cord-018265-twp33bb6	395	1	Promising	promising	JJ
cord-018265-twp33bb6	395	2	results	result	NNS
cord-018265-twp33bb6	395	3	have	have	VBP
cord-018265-twp33bb6	395	4	been	be	VBN
cord-018265-twp33bb6	395	5	reported	report	VBN
cord-018265-twp33bb6	395	6	using	use	VBG
cord-018265-twp33bb6	395	7	different	different	JJ
cord-018265-twp33bb6	395	8	types	type	NNS
cord-018265-twp33bb6	395	9	of	of	IN
cord-018265-twp33bb6	395	10	pseudoviruses	pseudoviruse	NNS
cord-018265-twp33bb6	395	11	,	,	,
cord-018265-twp33bb6	395	12	such	such	JJ
cord-018265-twp33bb6	395	13	as	as	IN
cord-018265-twp33bb6	395	14	virosomes	virosomes	NN
cord-018265-twp33bb6	395	15	and	and	CC
cord-018265-twp33bb6	395	16	virus	virus	NN
cord-018265-twp33bb6	395	17	-	-	HYPH
cord-018265-twp33bb6	395	18	like	like	JJ
cord-018265-twp33bb6	395	19	particles	particle	NNS
cord-018265-twp33bb6	395	20	(	(	-LRB-
cord-018265-twp33bb6	395	21	VLP	VLP	NNP
cord-018265-twp33bb6	395	22	)	)	-RRB-
cord-018265-twp33bb6	395	23	,	,	,
cord-018265-twp33bb6	395	24	which	which	WDT
cord-018265-twp33bb6	395	25	are	be	VBP
cord-018265-twp33bb6	395	26	non	non	JJ
cord-018265-twp33bb6	395	27	-	-	JJ
cord-018265-twp33bb6	395	28	replicating	replicate	VBG
cord-018265-twp33bb6	395	29	viral	viral	JJ
cord-018265-twp33bb6	395	30	-	-	HYPH
cord-018265-twp33bb6	395	31	like	like	JJ
cord-018265-twp33bb6	395	32	structures	structure	NNS
cord-018265-twp33bb6	395	33	.	.	.
cord-018265-twp33bb6	396	1	Virosomes	virosome	NNS
cord-018265-twp33bb6	396	2	are	be	VBP
cord-018265-twp33bb6	396	3	based	base	VBN
cord-018265-twp33bb6	396	4	on	on	IN
cord-018265-twp33bb6	396	5	the	the	DT
cord-018265-twp33bb6	396	6	principle	principle	NN
cord-018265-twp33bb6	396	7	of	of	IN
cord-018265-twp33bb6	396	8	reconstituting	reconstitute	VBG
cord-018265-twp33bb6	396	9	empty	empty	JJ
cord-018265-twp33bb6	396	10	viral	viral	JJ
cord-018265-twp33bb6	396	11	envelopes	envelope	NNS
cord-018265-twp33bb6	396	12	through	through	IN
cord-018265-twp33bb6	396	13	integration	integration	NN
cord-018265-twp33bb6	396	14	of	of	IN
cord-018265-twp33bb6	396	15	viral	viral	JJ
cord-018265-twp33bb6	396	16	envelope	envelope	NN
cord-018265-twp33bb6	396	17	proteins	protein	NNS
cord-018265-twp33bb6	396	18	in	in	IN
cord-018265-twp33bb6	396	19	liposomes	liposome	NNS
cord-018265-twp33bb6	396	20	.	.	.
cord-018265-twp33bb6	397	1	They	-PRON-	PRP
cord-018265-twp33bb6	397	2	offer	offer	VBP
cord-018265-twp33bb6	397	3	the	the	DT
cord-018265-twp33bb6	397	4	versatility	versatility	NN
cord-018265-twp33bb6	397	5	of	of	IN
cord-018265-twp33bb6	397	6	liposomes	liposome	NNS
cord-018265-twp33bb6	397	7	in	in	IN
cord-018265-twp33bb6	397	8	terms	term	NNS
cord-018265-twp33bb6	397	9	of	of	IN
cord-018265-twp33bb6	397	10	lipid	lipid	NN
cord-018265-twp33bb6	397	11	composition	composition	NN
cord-018265-twp33bb6	397	12	,	,	,
cord-018265-twp33bb6	397	13	with	with	IN
cord-018265-twp33bb6	397	14	the	the	DT
cord-018265-twp33bb6	397	15	advantage	advantage	NN
cord-018265-twp33bb6	397	16	of	of	IN
cord-018265-twp33bb6	397	17	including	include	VBG
cord-018265-twp33bb6	397	18	viral	viral	JJ
cord-018265-twp33bb6	397	19	membrane	membrane	NN
cord-018265-twp33bb6	397	20	proteins	protein	NNS
cord-018265-twp33bb6	397	21	.	.	.
cord-018265-twp33bb6	398	1	Virosomes	virosome	NNS
cord-018265-twp33bb6	398	2	are	be	VBP
cord-018265-twp33bb6	398	3	produced	produce	VBN
cord-018265-twp33bb6	398	4	by	by	IN
cord-018265-twp33bb6	398	5	disassembling	disassemble	VBG
cord-018265-twp33bb6	398	6	the	the	DT
cord-018265-twp33bb6	398	7	viral	viral	JJ
cord-018265-twp33bb6	398	8	membrane	membrane	NN
cord-018265-twp33bb6	398	9	envelope	envelope	NN
cord-018265-twp33bb6	398	10	with	with	IN
cord-018265-twp33bb6	398	11	detergents	detergent	NNS
cord-018265-twp33bb6	398	12	.	.	.
cord-018265-twp33bb6	399	1	Then	then	RB
cord-018265-twp33bb6	399	2	,	,	,
cord-018265-twp33bb6	399	3	the	the	DT
cord-018265-twp33bb6	399	4	viral	viral	JJ
cord-018265-twp33bb6	399	5	nucleocapsid	nucleocapsid	NN
cord-018265-twp33bb6	399	6	is	be	VBZ
cord-018265-twp33bb6	399	7	removed	remove	VBN
cord-018265-twp33bb6	399	8	by	by	IN
cord-018265-twp33bb6	399	9	ultracentrifugation	ultracentrifugation	NN
cord-018265-twp33bb6	399	10	before	before	IN
cord-018265-twp33bb6	399	11	reconstitution	reconstitution	NN
cord-018265-twp33bb6	399	12	(	(	-LRB-
cord-018265-twp33bb6	399	13	Fig	Fig	NNP
cord-018265-twp33bb6	399	14	.	.	.
cord-018265-twp33bb6	399	15	1	1	CD
cord-018265-twp33bb6	399	16	)	)	-RRB-
cord-018265-twp33bb6	399	17	.	.	.
cord-018265-twp33bb6	400	1	In	in	IN
cord-018265-twp33bb6	400	2	contrast	contrast	NN
cord-018265-twp33bb6	400	3	,	,	,
cord-018265-twp33bb6	400	4	VLP	VLP	NNP
cord-018265-twp33bb6	400	5	exploit	exploit	VB
cord-018265-twp33bb6	400	6	the	the	DT
cord-018265-twp33bb6	400	7	capacity	capacity	NN
cord-018265-twp33bb6	400	8	of	of	IN
cord-018265-twp33bb6	400	9	recombinant	recombinant	JJ
cord-018265-twp33bb6	400	10	viral	viral	JJ
cord-018265-twp33bb6	400	11	coat	coat	NN
cord-018265-twp33bb6	400	12	proteins	protein	NNS
cord-018265-twp33bb6	400	13	to	to	TO
cord-018265-twp33bb6	400	14	spontaneously	spontaneously	RB
cord-018265-twp33bb6	400	15	self	self	NN
cord-018265-twp33bb6	400	16	-	-	HYPH
cord-018265-twp33bb6	400	17	assemble	assemble	JJ
cord-018265-twp33bb6	400	18	,	,	,
cord-018265-twp33bb6	400	19	thereby	thereby	RB
cord-018265-twp33bb6	400	20	mimicking	mimic	VBG
cord-018265-twp33bb6	400	21	at	at	IN
cord-018265-twp33bb6	400	22	structural	structural	JJ
cord-018265-twp33bb6	400	23	level	level	NN
cord-018265-twp33bb6	400	24	the	the	DT
cord-018265-twp33bb6	400	25	viral	viral	JJ
cord-018265-twp33bb6	400	26	capsid	capsid	NN
cord-018265-twp33bb6	400	27	.	.	.
cord-018265-twp33bb6	401	1	VLP	VLP	NNP
cord-018265-twp33bb6	401	2	can	can	MD
cord-018265-twp33bb6	401	3	be	be	VB
cord-018265-twp33bb6	401	4	isolated	isolate	VBN
cord-018265-twp33bb6	401	5	after	after	IN
cord-018265-twp33bb6	401	6	protein	protein	NN
cord-018265-twp33bb6	401	7	expression	expression	NN
cord-018265-twp33bb6	401	8	in	in	IN
cord-018265-twp33bb6	401	9	eukaryotic	eukaryotic	JJ
cord-018265-twp33bb6	401	10	cells	cell	NNS
cord-018265-twp33bb6	401	11	or	or	CC
cord-018265-twp33bb6	401	12	by	by	IN
cord-018265-twp33bb6	401	13	in	in	FW
cord-018265-twp33bb6	401	14	vitro	vitro	FW
cord-018265-twp33bb6	401	15	assemblage	assemblage	NN
cord-018265-twp33bb6	401	16	from	from	IN
cord-018265-twp33bb6	401	17	subunits	subunit	NNS
cord-018265-twp33bb6	401	18	produced	produce	VBN
cord-018265-twp33bb6	401	19	in	in	IN
cord-018265-twp33bb6	401	20	an	an	DT
cord-018265-twp33bb6	401	21	heterologous	heterologous	JJ
cord-018265-twp33bb6	401	22	system	system	NN
cord-018265-twp33bb6	401	23	[	[	-LRB-
cord-018265-twp33bb6	401	24	156	156	CD
cord-018265-twp33bb6	401	25	]	]	-RRB-
cord-018265-twp33bb6	401	26	.	.	.
cord-018265-twp33bb6	402	1	Their	-PRON-	PRP$
cord-018265-twp33bb6	402	2	main	main	JJ
cord-018265-twp33bb6	402	3	advantages	advantage	NNS
cord-018265-twp33bb6	402	4	are	be	VBP
cord-018265-twp33bb6	402	5	the	the	DT
cord-018265-twp33bb6	402	6	lack	lack	NN
cord-018265-twp33bb6	402	7	the	the	DT
cord-018265-twp33bb6	402	8	viral	viral	JJ
cord-018265-twp33bb6	402	9	genetic	genetic	JJ
cord-018265-twp33bb6	402	10	material	material	NN
cord-018265-twp33bb6	402	11	with	with	IN
cord-018265-twp33bb6	402	12	an	an	DT
cord-018265-twp33bb6	402	13	"	"	``
cord-018265-twp33bb6	402	14	intact	intact	JJ
cord-018265-twp33bb6	402	15	"	"	''
cord-018265-twp33bb6	402	16	envelope	envelope	NN
cord-018265-twp33bb6	402	17	,	,	,
cord-018265-twp33bb6	402	18	and	and	CC
cord-018265-twp33bb6	402	19	the	the	DT
cord-018265-twp33bb6	402	20	fact	fact	NN
cord-018265-twp33bb6	402	21	that	that	IN
cord-018265-twp33bb6	402	22	they	-PRON-	PRP
cord-018265-twp33bb6	402	23	are	be	VBP
cord-018265-twp33bb6	402	24	significantly	significantly	RB
cord-018265-twp33bb6	402	25	more	more	RBR
cord-018265-twp33bb6	402	26	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	402	27	than	than	IN
cord-018265-twp33bb6	402	28	soluble	soluble	JJ
cord-018265-twp33bb6	402	29	proteins	protein	NNS
cord-018265-twp33bb6	402	30	.	.	.
cord-018265-twp33bb6	403	1	They	-PRON-	PRP
cord-018265-twp33bb6	403	2	can	can	MD
cord-018265-twp33bb6	403	3	be	be	VB
cord-018265-twp33bb6	403	4	used	use	VBN
cord-018265-twp33bb6	403	5	as	as	IN
cord-018265-twp33bb6	403	6	vaccines	vaccine	NNS
cord-018265-twp33bb6	403	7	per	per	IN
cord-018265-twp33bb6	403	8	se	se	FW
cord-018265-twp33bb6	403	9	,	,	,
cord-018265-twp33bb6	403	10	as	as	RB
cord-018265-twp33bb6	403	11	well	well	RB
cord-018265-twp33bb6	403	12	as	as	IN
cord-018265-twp33bb6	403	13	a	a	DT
cord-018265-twp33bb6	403	14	delivery	delivery	NN
cord-018265-twp33bb6	403	15	system	system	NN
cord-018265-twp33bb6	403	16	for	for	IN
cord-018265-twp33bb6	403	17	protein	protein	NN
cord-018265-twp33bb6	403	18	-	-	HYPH
cord-018265-twp33bb6	403	19	or	or	CC
cord-018265-twp33bb6	403	20	nucleic	nucleic	JJ
cord-018265-twp33bb6	403	21	acid	acid	NN
cord-018265-twp33bb6	403	22	based	base	VBN
cord-018265-twp33bb6	403	23	vaccines	vaccine	NNS
cord-018265-twp33bb6	403	24	,	,	,
cord-018265-twp33bb6	403	25	or	or	CC
cord-018265-twp33bb6	403	26	as	as	IN
cord-018265-twp33bb6	403	27	carriers	carrier	NNS
cord-018265-twp33bb6	403	28	for	for	IN
cord-018265-twp33bb6	403	29	small	small	JJ
cord-018265-twp33bb6	403	30	molecules	molecule	NNS
cord-018265-twp33bb6	403	31	.	.	.
cord-018265-twp33bb6	404	1	Foreign	foreign	JJ
cord-018265-twp33bb6	404	2	antigens	antigen	NNS
cord-018265-twp33bb6	404	3	can	can	MD
cord-018265-twp33bb6	404	4	be	be	VB
cord-018265-twp33bb6	404	5	expressed	express	VBN
cord-018265-twp33bb6	404	6	on	on	IN
cord-018265-twp33bb6	404	7	their	-PRON-	PRP$
cord-018265-twp33bb6	404	8	surface	surface	NN
cord-018265-twp33bb6	404	9	,	,	,
cord-018265-twp33bb6	404	10	or	or	CC
cord-018265-twp33bb6	404	11	can	can	MD
cord-018265-twp33bb6	404	12	be	be	VB
cord-018265-twp33bb6	404	13	simply	simply	RB
cord-018265-twp33bb6	404	14	encapsulated	encapsulate	VBN
cord-018265-twp33bb6	404	15	.	.	.
cord-018265-twp33bb6	405	1	In	in	IN
cord-018265-twp33bb6	405	2	addition	addition	NN
cord-018265-twp33bb6	405	3	,	,	,
cord-018265-twp33bb6	405	4	amphiphilic	amphiphilic	JJ
cord-018265-twp33bb6	405	5	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	405	6	can	can	MD
cord-018265-twp33bb6	405	7	be	be	VB
cord-018265-twp33bb6	405	8	incorporated	incorporate	VBN
cord-018265-twp33bb6	405	9	into	into	IN
cord-018265-twp33bb6	405	10	their	-PRON-	PRP$
cord-018265-twp33bb6	405	11	membranes	membrane	NNS
cord-018265-twp33bb6	405	12	,	,	,
cord-018265-twp33bb6	405	13	thereby	thereby	RB
cord-018265-twp33bb6	405	14	offering	offer	VBG
cord-018265-twp33bb6	405	15	the	the	DT
cord-018265-twp33bb6	405	16	advantage	advantage	NN
cord-018265-twp33bb6	405	17	of	of	IN
cord-018265-twp33bb6	405	18	combining	combine	VBG
cord-018265-twp33bb6	405	19	an	an	DT
cord-018265-twp33bb6	405	20	adjuvant	adjuvant	NN
cord-018265-twp33bb6	405	21	and	and	CC
cord-018265-twp33bb6	405	22	the	the	DT
cord-018265-twp33bb6	405	23	antigen	antigen	NN
cord-018265-twp33bb6	405	24	in	in	IN
cord-018265-twp33bb6	405	25	one	one	CD
cord-018265-twp33bb6	405	26	entity	entity	NN
cord-018265-twp33bb6	405	27	without	without	IN
cord-018265-twp33bb6	405	28	a	a	DT
cord-018265-twp33bb6	405	29	covalent	covalent	JJ
cord-018265-twp33bb6	405	30	attachment	attachment	NN
cord-018265-twp33bb6	405	31	.	.	.
cord-018265-twp33bb6	406	1	Pseudoviruses	pseudoviruse	NNS
cord-018265-twp33bb6	406	2	are	be	VBP
cord-018265-twp33bb6	406	3	especially	especially	RB
cord-018265-twp33bb6	406	4	attractive	attractive	JJ
cord-018265-twp33bb6	406	5	for	for	IN
cord-018265-twp33bb6	406	6	mucosal	mucosal	JJ
cord-018265-twp33bb6	406	7	vaccination	vaccination	NN
cord-018265-twp33bb6	406	8	protocols	protocol	NNS
cord-018265-twp33bb6	406	9	,	,	,
cord-018265-twp33bb6	406	10	since	since	IN
cord-018265-twp33bb6	406	11	they	-PRON-	PRP
cord-018265-twp33bb6	406	12	offer	offer	VBP
cord-018265-twp33bb6	406	13	the	the	DT
cord-018265-twp33bb6	406	14	opportunity	opportunity	NN
cord-018265-twp33bb6	406	15	to	to	TO
cord-018265-twp33bb6	406	16	use	use	VB
cord-018265-twp33bb6	406	17	the	the	DT
cord-018265-twp33bb6	406	18	natural	natural	JJ
cord-018265-twp33bb6	406	19	route	route	NN
cord-018265-twp33bb6	406	20	of	of	IN
cord-018265-twp33bb6	406	21	transmission	transmission	NN
cord-018265-twp33bb6	406	22	of	of	IN
cord-018265-twp33bb6	406	23	the	the	DT
cord-018265-twp33bb6	406	24	agents	agent	NNS
cord-018265-twp33bb6	406	25	.	.	.
cord-018265-twp33bb6	407	1	Induction	induction	NN
cord-018265-twp33bb6	407	2	of	of	IN
cord-018265-twp33bb6	407	3	serum	serum	NN
cord-018265-twp33bb6	407	4	antibodies	antibody	NNS
cord-018265-twp33bb6	407	5	,	,	,
cord-018265-twp33bb6	407	6	secretory	secretory	JJ
cord-018265-twp33bb6	407	7	IgA	IgA	NNP
cord-018265-twp33bb6	407	8	,	,	,
cord-018265-twp33bb6	407	9	T	T	NNP
cord-018265-twp33bb6	407	10	helper	helper	NN
cord-018265-twp33bb6	407	11	and	and	CC
cord-018265-twp33bb6	407	12	CTL	CTL	NNP
cord-018265-twp33bb6	407	13	responses	response	NNS
cord-018265-twp33bb6	407	14	,	,	,
cord-018265-twp33bb6	407	15	and	and	CC
cord-018265-twp33bb6	407	16	protection	protection	NN
cord-018265-twp33bb6	407	17	against	against	IN
cord-018265-twp33bb6	407	18	mucosal	mucosal	JJ
cord-018265-twp33bb6	407	19	pathogen	pathogen	NN
cord-018265-twp33bb6	407	20	challenge	challenge	NN
cord-018265-twp33bb6	407	21	has	have	VBZ
cord-018265-twp33bb6	407	22	been	be	VBN
cord-018265-twp33bb6	407	23	reported	report	VBN
cord-018265-twp33bb6	407	24	from	from	IN
cord-018265-twp33bb6	407	25	studies	study	NNS
cord-018265-twp33bb6	407	26	in	in	IN
cord-018265-twp33bb6	407	27	animals	animal	NNS
cord-018265-twp33bb6	407	28	and	and	CC
cord-018265-twp33bb6	407	29	humans	human	NNS
cord-018265-twp33bb6	407	30	[	[	-LRB-
cord-018265-twp33bb6	407	31	157	157	CD
cord-018265-twp33bb6	407	32	]	]	-RRB-
cord-018265-twp33bb6	407	33	[	[	-LRB-
cord-018265-twp33bb6	407	34	158	158	CD
cord-018265-twp33bb6	407	35	]	]	-RRB-
cord-018265-twp33bb6	407	36	[	[	-LRB-
cord-018265-twp33bb6	407	37	159	159	CD
cord-018265-twp33bb6	407	38	]	]	-RRB-
cord-018265-twp33bb6	407	39	.	.	.
cord-018265-twp33bb6	408	1	The	the	DT
cord-018265-twp33bb6	408	2	virosomes	virosome	NNS
cord-018265-twp33bb6	408	3	generated	generate	VBN
cord-018265-twp33bb6	408	4	using	use	VBG
cord-018265-twp33bb6	408	5	the	the	DT
cord-018265-twp33bb6	408	6	influenza	influenza	NN
cord-018265-twp33bb6	408	7	virus	virus	NN
cord-018265-twp33bb6	408	8	retain	retain	VB
cord-018265-twp33bb6	408	9	membrane	membrane	NN
cord-018265-twp33bb6	408	10	fusion	fusion	NN
cord-018265-twp33bb6	408	11	properties	property	NNS
cord-018265-twp33bb6	408	12	very	very	RB
cord-018265-twp33bb6	408	13	similar	similar	JJ
cord-018265-twp33bb6	408	14	to	to	IN
cord-018265-twp33bb6	408	15	the	the	DT
cord-018265-twp33bb6	408	16	naïve	naïve	JJ
cord-018265-twp33bb6	408	17	virus	virus	NN
cord-018265-twp33bb6	408	18	.	.	.
cord-018265-twp33bb6	409	1	Therefore	therefore	RB
cord-018265-twp33bb6	409	2	,	,	,
cord-018265-twp33bb6	409	3	they	-PRON-	PRP
cord-018265-twp33bb6	409	4	are	be	VBP
cord-018265-twp33bb6	409	5	able	able	JJ
cord-018265-twp33bb6	409	6	to	to	TO
cord-018265-twp33bb6	409	7	deliver	deliver	VB
cord-018265-twp33bb6	409	8	material	material	NN
cord-018265-twp33bb6	409	9	to	to	IN
cord-018265-twp33bb6	409	10	the	the	DT
cord-018265-twp33bb6	409	11	cytosol	cytosol	NN
cord-018265-twp33bb6	409	12	of	of	IN
cord-018265-twp33bb6	409	13	target	target	NN
cord-018265-twp33bb6	409	14	cells	cell	NNS
cord-018265-twp33bb6	409	15	,	,	,
cord-018265-twp33bb6	409	16	offering	offer	VBG
cord-018265-twp33bb6	409	17	the	the	DT
cord-018265-twp33bb6	409	18	possibility	possibility	NN
cord-018265-twp33bb6	409	19	to	to	TO
cord-018265-twp33bb6	409	20	access	access	VB
cord-018265-twp33bb6	409	21	the	the	DT
cord-018265-twp33bb6	409	22	MHC	MHC	NNP
cord-018265-twp33bb6	409	23	class	class	NN
cord-018265-twp33bb6	409	24	I	i	NN
cord-018265-twp33bb6	409	25	-	-	HYPH
cord-018265-twp33bb6	409	26	restricted	restrict	VBN
cord-018265-twp33bb6	409	27	pathway	pathway	NN
cord-018265-twp33bb6	409	28	of	of	IN
cord-018265-twp33bb6	409	29	antigen	antigen	NN
cord-018265-twp33bb6	409	30	presentation	presentation	NN
cord-018265-twp33bb6	409	31	to	to	IN
cord-018265-twp33bb6	409	32	prime	prime	JJ
cord-018265-twp33bb6	409	33	CTL	CTL	NNP
cord-018265-twp33bb6	409	34	activity	activity	NN
cord-018265-twp33bb6	409	35	[	[	-LRB-
cord-018265-twp33bb6	409	36	160	160	CD
cord-018265-twp33bb6	409	37	]	]	-RRB-
cord-018265-twp33bb6	409	38	[	[	-LRB-
cord-018265-twp33bb6	409	39	161	161	CD
cord-018265-twp33bb6	409	40	]	]	-RRB-
cord-018265-twp33bb6	409	41	[	[	-LRB-
cord-018265-twp33bb6	409	42	162	162	CD
cord-018265-twp33bb6	409	43	]	]	-RRB-
cord-018265-twp33bb6	409	44	.	.	.
cord-018265-twp33bb6	409	45	 	 	_SP
cord-018265-twp33bb6	410	1	Bacterial	bacterial	JJ
cord-018265-twp33bb6	410	2	toxins	toxin	NNS
cord-018265-twp33bb6	410	3	and	and	CC
cord-018265-twp33bb6	410	4	their	-PRON-	PRP$
cord-018265-twp33bb6	410	5	derivatives	derivative	NNS
cord-018265-twp33bb6	410	6	are	be	VBP
cord-018265-twp33bb6	410	7	among	among	IN
cord-018265-twp33bb6	410	8	the	the	DT
cord-018265-twp33bb6	410	9	first	first	JJ
cord-018265-twp33bb6	410	10	molecules	molecule	NNS
cord-018265-twp33bb6	410	11	that	that	WDT
cord-018265-twp33bb6	410	12	have	have	VBP
cord-018265-twp33bb6	410	13	been	be	VBN
cord-018265-twp33bb6	410	14	used	use	VBN
cord-018265-twp33bb6	410	15	as	as	IN
cord-018265-twp33bb6	410	16	mucosal	mucosal	JJ
cord-018265-twp33bb6	410	17	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	410	18	.	.	.
cord-018265-twp33bb6	411	1	They	-PRON-	PRP
cord-018265-twp33bb6	411	2	are	be	VBP
cord-018265-twp33bb6	411	3	characterized	characterize	VBN
cord-018265-twp33bb6	411	4	by	by	IN
cord-018265-twp33bb6	411	5	the	the	DT
cord-018265-twp33bb6	411	6	presence	presence	NN
cord-018265-twp33bb6	411	7	of	of	IN
cord-018265-twp33bb6	411	8	an	an	DT
cord-018265-twp33bb6	411	9	A	A	NNP
cord-018265-twp33bb6	411	10	moiety	moiety	NN
cord-018265-twp33bb6	411	11	with	with	IN
cord-018265-twp33bb6	411	12	enzymatic	enzymatic	JJ
cord-018265-twp33bb6	411	13	activity	activity	NN
cord-018265-twp33bb6	411	14	,	,	,
cord-018265-twp33bb6	411	15	and	and	CC
cord-018265-twp33bb6	411	16	a	a	DT
cord-018265-twp33bb6	411	17	B	b	NN
cord-018265-twp33bb6	411	18	moiety	moiety	NN
cord-018265-twp33bb6	411	19	that	that	WDT
cord-018265-twp33bb6	411	20	mediates	mediate	VBZ
cord-018265-twp33bb6	411	21	toxin	toxin	NN
cord-018265-twp33bb6	411	22	binding	bind	VBG
cord-018265-twp33bb6	411	23	to	to	IN
cord-018265-twp33bb6	411	24	the	the	DT
cord-018265-twp33bb6	411	25	target	target	NN
cord-018265-twp33bb6	411	26	cells	cell	NNS
cord-018265-twp33bb6	411	27	.	.	.
cord-018265-twp33bb6	412	1	Cholera	cholera	NN
cord-018265-twp33bb6	412	2	toxin	toxin	NN
cord-018265-twp33bb6	412	3	and	and	CC
cord-018265-twp33bb6	412	4	the	the	DT
cord-018265-twp33bb6	412	5	closely	closely	RB
cord-018265-twp33bb6	412	6	related	related	JJ
cord-018265-twp33bb6	412	7	Escherichia	Escherichia	NNP
cord-018265-twp33bb6	412	8	coli	coli	NNS
cord-018265-twp33bb6	412	9	heat	heat	NN
cord-018265-twp33bb6	412	10	-	-	HYPH
cord-018265-twp33bb6	412	11	labile	labile	JJ
cord-018265-twp33bb6	412	12	toxin	toxin	NN
cord-018265-twp33bb6	412	13	showed	show	VBD
cord-018265-twp33bb6	412	14	potent	potent	JJ
cord-018265-twp33bb6	412	15	adjuvant	adjuvant	NN
cord-018265-twp33bb6	412	16	activity	activity	NN
cord-018265-twp33bb6	412	17	when	when	WRB
cord-018265-twp33bb6	412	18	co	co	NN
cord-018265-twp33bb6	412	19	-	-	VBN
cord-018265-twp33bb6	412	20	administrated	administrate	VBN
cord-018265-twp33bb6	412	21	with	with	IN
cord-018265-twp33bb6	412	22	different	different	JJ
cord-018265-twp33bb6	412	23	antigens	antigen	NNS
cord-018265-twp33bb6	412	24	by	by	IN
cord-018265-twp33bb6	412	25	the	the	DT
cord-018265-twp33bb6	412	26	mucosal	mucosal	JJ
cord-018265-twp33bb6	412	27	route	route	NN
cord-018265-twp33bb6	412	28	[	[	-LRB-
cord-018265-twp33bb6	412	29	163	163	CD
cord-018265-twp33bb6	412	30	]	]	-RRB-
cord-018265-twp33bb6	412	31	[	[	-LRB-
cord-018265-twp33bb6	412	32	164	164	CD
cord-018265-twp33bb6	412	33	]	]	-RRB-
cord-018265-twp33bb6	412	34	[	[	-LRB-
cord-018265-twp33bb6	412	35	165	165	CD
cord-018265-twp33bb6	412	36	]	]	-RRB-
cord-018265-twp33bb6	412	37	.	.	.
cord-018265-twp33bb6	413	1	However	however	RB
cord-018265-twp33bb6	413	2	,	,	,
cord-018265-twp33bb6	413	3	their	-PRON-	PRP$
cord-018265-twp33bb6	413	4	use	use	NN
cord-018265-twp33bb6	413	5	in	in	IN
cord-018265-twp33bb6	413	6	humans	human	NNS
cord-018265-twp33bb6	413	7	is	be	VBZ
cord-018265-twp33bb6	413	8	hampered	hamper	VBN
cord-018265-twp33bb6	413	9	by	by	IN
cord-018265-twp33bb6	413	10	their	-PRON-	PRP$
cord-018265-twp33bb6	413	11	intrinsic	intrinsic	JJ
cord-018265-twp33bb6	413	12	toxicity	toxicity	NN
cord-018265-twp33bb6	413	13	.	.	.
cord-018265-twp33bb6	414	1	Thus	thus	RB
cord-018265-twp33bb6	414	2	,	,	,
cord-018265-twp33bb6	414	3	mutated	mutated	JJ
cord-018265-twp33bb6	414	4	derivatives	derivative	NNS
cord-018265-twp33bb6	414	5	were	be	VBD
cord-018265-twp33bb6	414	6	developed	develop	VBN
cord-018265-twp33bb6	414	7	,	,	,
cord-018265-twp33bb6	414	8	in	in	IN
cord-018265-twp33bb6	414	9	which	which	WDT
cord-018265-twp33bb6	414	10	the	the	DT
cord-018265-twp33bb6	414	11	A	a	DT
cord-018265-twp33bb6	414	12	subunit	subunit	NN
cord-018265-twp33bb6	414	13	was	be	VBD
cord-018265-twp33bb6	414	14	modified	modify	VBN
cord-018265-twp33bb6	414	15	to	to	TO
cord-018265-twp33bb6	414	16	remove	remove	VB
cord-018265-twp33bb6	414	17	the	the	DT
cord-018265-twp33bb6	414	18	ADP	ADP	NNP
cord-018265-twp33bb6	414	19	-	-	HYPH
cord-018265-twp33bb6	414	20	ribosylating	ribosylate	VBG
cord-018265-twp33bb6	414	21	activity	activity	NN
cord-018265-twp33bb6	414	22	.	.	.
cord-018265-twp33bb6	415	1	The	the	DT
cord-018265-twp33bb6	415	2	resulting	result	VBG
cord-018265-twp33bb6	415	3	polypeptides	polypeptide	NNS
cord-018265-twp33bb6	415	4	retain	retain	VBP
cord-018265-twp33bb6	415	5	their	-PRON-	PRP$
cord-018265-twp33bb6	415	6	adjuvanticity	adjuvanticity	NN
cord-018265-twp33bb6	415	7	,	,	,
cord-018265-twp33bb6	415	8	in	in	IN
cord-018265-twp33bb6	415	9	the	the	DT
cord-018265-twp33bb6	415	10	absence	absence	NN
cord-018265-twp33bb6	415	11	of	of	IN
cord-018265-twp33bb6	415	12	detectable	detectable	JJ
cord-018265-twp33bb6	415	13	toxicity	toxicity	NN
cord-018265-twp33bb6	415	14	[	[	-LRB-
cord-018265-twp33bb6	415	15	166	166	CD
cord-018265-twp33bb6	415	16	]	]	-RRB-
cord-018265-twp33bb6	415	17	[	[	-LRB-
cord-018265-twp33bb6	415	18	167	167	CD
cord-018265-twp33bb6	415	19	]	]	-RRB-
cord-018265-twp33bb6	415	20	[	[	-LRB-
cord-018265-twp33bb6	415	21	168	168	CD
cord-018265-twp33bb6	415	22	]	]	-RRB-
cord-018265-twp33bb6	415	23	.	.	.
cord-018265-twp33bb6	416	1	However	however	RB
cord-018265-twp33bb6	416	2	,	,	,
cord-018265-twp33bb6	416	3	additional	additional	JJ
cord-018265-twp33bb6	416	4	studies	study	NNS
cord-018265-twp33bb6	416	5	have	have	VBP
cord-018265-twp33bb6	416	6	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	416	7	that	that	IN
cord-018265-twp33bb6	416	8	even	even	RB
cord-018265-twp33bb6	416	9	these	these	DT
cord-018265-twp33bb6	416	10	derivatives	derivative	NNS
cord-018265-twp33bb6	416	11	can	can	MD
cord-018265-twp33bb6	416	12	lead	lead	VB
cord-018265-twp33bb6	416	13	to	to	IN
cord-018265-twp33bb6	416	14	potential	potential	JJ
cord-018265-twp33bb6	416	15	severe	severe	JJ
cord-018265-twp33bb6	416	16	side	side	NN
cord-018265-twp33bb6	416	17	-	-	HYPH
cord-018265-twp33bb6	416	18	effects	effect	NNS
cord-018265-twp33bb6	416	19	,	,	,
cord-018265-twp33bb6	416	20	such	such	JJ
cord-018265-twp33bb6	416	21	as	as	IN
cord-018265-twp33bb6	416	22	retrograde	retrograde	JJ
cord-018265-twp33bb6	416	23	homing	homing	NN
cord-018265-twp33bb6	416	24	of	of	IN
cord-018265-twp33bb6	416	25	adjuvant	adjuvant	NN
cord-018265-twp33bb6	416	26	and	and	CC
cord-018265-twp33bb6	416	27	antigen	antigen	NN
cord-018265-twp33bb6	416	28	to	to	IN
cord-018265-twp33bb6	416	29	neural	neural	JJ
cord-018265-twp33bb6	416	30	tissues	tissue	NNS
cord-018265-twp33bb6	416	31	[	[	-LRB-
cord-018265-twp33bb6	416	32	169	169	CD
cord-018265-twp33bb6	416	33	]	]	-RRB-
cord-018265-twp33bb6	416	34	.	.	.
cord-018265-twp33bb6	417	1	This	this	DT
cord-018265-twp33bb6	417	2	might	may	MD
cord-018265-twp33bb6	417	3	explain	explain	VB
cord-018265-twp33bb6	417	4	,	,	,
cord-018265-twp33bb6	417	5	at	at	IN
cord-018265-twp33bb6	417	6	least	least	JJS
cord-018265-twp33bb6	417	7	in	in	IN
cord-018265-twp33bb6	417	8	part	part	NN
cord-018265-twp33bb6	417	9	,	,	,
cord-018265-twp33bb6	417	10	the	the	DT
cord-018265-twp33bb6	417	11	side	side	NN
cord-018265-twp33bb6	417	12	-	-	HYPH
cord-018265-twp33bb6	417	13	effects	effect	NNS
cord-018265-twp33bb6	417	14	observed	observe	VBN
cord-018265-twp33bb6	417	15	after	after	IN
cord-018265-twp33bb6	417	16	intranasal	intranasal	NN
cord-018265-twp33bb6	417	17	vaccination	vaccination	NN
cord-018265-twp33bb6	417	18	against	against	IN
cord-018265-twp33bb6	417	19	influenza	influenza	NN
cord-018265-twp33bb6	417	20	with	with	IN
cord-018265-twp33bb6	417	21	a	a	DT
cord-018265-twp33bb6	417	22	virosomes	virosomes	NN
cord-018265-twp33bb6	417	23	-	-	HYPH
cord-018265-twp33bb6	417	24	based	base	VBN
cord-018265-twp33bb6	417	25	formulation	formulation	NN
cord-018265-twp33bb6	417	26	containing	contain	VBG
cord-018265-twp33bb6	417	27	heat	heat	NN
cord-018265-twp33bb6	417	28	-	-	HYPH
cord-018265-twp33bb6	417	29	labile	labile	JJ
cord-018265-twp33bb6	417	30	toxin	toxin	NN
cord-018265-twp33bb6	417	31	(	(	-LRB-
cord-018265-twp33bb6	417	32	i.e.	i.e.	FW
cord-018265-twp33bb6	417	33	,	,	,
cord-018265-twp33bb6	417	34	Bell	Bell	NNP
cord-018265-twp33bb6	417	35	's	's	POS
cord-018265-twp33bb6	417	36	palsy	palsy	NN
cord-018265-twp33bb6	417	37	)	)	-RRB-
cord-018265-twp33bb6	417	38	,	,	,
cord-018265-twp33bb6	417	39	which	which	WDT
cord-018265-twp33bb6	417	40	in	in	IN
cord-018265-twp33bb6	417	41	turn	turn	NN
cord-018265-twp33bb6	417	42	led	lead	VBD
cord-018265-twp33bb6	417	43	to	to	IN
cord-018265-twp33bb6	417	44	its	-PRON-	PRP$
cord-018265-twp33bb6	417	45	retraction	retraction	NN
cord-018265-twp33bb6	417	46	from	from	IN
cord-018265-twp33bb6	417	47	the	the	DT
cord-018265-twp33bb6	417	48	market	market	NN
cord-018265-twp33bb6	417	49	.	.	.
cord-018265-twp33bb6	418	1	However	however	RB
cord-018265-twp33bb6	418	2	,	,	,
cord-018265-twp33bb6	418	3	chimeric	chimeric	JJ
cord-018265-twp33bb6	418	4	derivatives	derivative	NNS
cord-018265-twp33bb6	418	5	lacking	lack	VBG
cord-018265-twp33bb6	418	6	the	the	DT
cord-018265-twp33bb6	418	7	targeting	targeting	NN
cord-018265-twp33bb6	418	8	moiety	moiety	NN
cord-018265-twp33bb6	418	9	for	for	IN
cord-018265-twp33bb6	418	10	neural	neural	JJ
cord-018265-twp33bb6	418	11	tissues	tissue	NNS
cord-018265-twp33bb6	418	12	(	(	-LRB-
cord-018265-twp33bb6	418	13	i.e.	i.e.	FW
cord-018265-twp33bb6	418	14	,	,	,
cord-018265-twp33bb6	418	15	B	b	NN
cord-018265-twp33bb6	418	16	subunit	subunit	NN
cord-018265-twp33bb6	418	17	)	)	-RRB-
cord-018265-twp33bb6	418	18	are	be	VBP
cord-018265-twp33bb6	418	19	now	now	RB
cord-018265-twp33bb6	418	20	available	available	JJ
cord-018265-twp33bb6	418	21	[	[	-LRB-
cord-018265-twp33bb6	418	22	170	170	CD
cord-018265-twp33bb6	418	23	]	]	-RRB-
cord-018265-twp33bb6	418	24	.	.	.
cord-018265-twp33bb6	419	1	They	-PRON-	PRP
cord-018265-twp33bb6	419	2	might	may	MD
cord-018265-twp33bb6	419	3	allow	allow	VB
cord-018265-twp33bb6	419	4	the	the	DT
cord-018265-twp33bb6	419	5	exploitation	exploitation	NN
cord-018265-twp33bb6	419	6	of	of	IN
cord-018265-twp33bb6	419	7	the	the	DT
cord-018265-twp33bb6	419	8	high	high	JJ
cord-018265-twp33bb6	419	9	potential	potential	NN
cord-018265-twp33bb6	419	10	of	of	IN
cord-018265-twp33bb6	419	11	these	these	DT
cord-018265-twp33bb6	419	12	molecules	molecule	NNS
cord-018265-twp33bb6	419	13	for	for	IN
cord-018265-twp33bb6	419	14	the	the	DT
cord-018265-twp33bb6	419	15	development	development	NN
cord-018265-twp33bb6	419	16	of	of	IN
cord-018265-twp33bb6	419	17	vaccines	vaccine	NNS
cord-018265-twp33bb6	419	18	against	against	IN
cord-018265-twp33bb6	419	19	respiratory	respiratory	JJ
cord-018265-twp33bb6	419	20	pathogens	pathogen	NNS
cord-018265-twp33bb6	419	21	.	.	.
cord-018265-twp33bb6	420	1	In	in	IN
cord-018265-twp33bb6	420	2	fact	fact	NN
cord-018265-twp33bb6	420	3	,	,	,
cord-018265-twp33bb6	420	4	preclinical	preclinical	JJ
cord-018265-twp33bb6	420	5	studies	study	NNS
cord-018265-twp33bb6	420	6	provided	provide	VBD
cord-018265-twp33bb6	420	7	the	the	DT
cord-018265-twp33bb6	420	8	proof	proof	NN
cord-018265-twp33bb6	420	9	-	-	HYPH
cord-018265-twp33bb6	420	10	of	of	IN
cord-018265-twp33bb6	420	11	-	-	HYPH
cord-018265-twp33bb6	420	12	concept	concept	NN
cord-018265-twp33bb6	420	13	for	for	IN
cord-018265-twp33bb6	420	14	the	the	DT
cord-018265-twp33bb6	420	15	usefulness	usefulness	NN
cord-018265-twp33bb6	420	16	of	of	IN
cord-018265-twp33bb6	420	17	derivatives	derivative	NNS
cord-018265-twp33bb6	420	18	of	of	IN
cord-018265-twp33bb6	420	19	bacterial	bacterial	JJ
cord-018265-twp33bb6	420	20	toxins	toxin	NNS
cord-018265-twp33bb6	420	21	in	in	IN
cord-018265-twp33bb6	420	22	the	the	DT
cord-018265-twp33bb6	420	23	generation	generation	NN
cord-018265-twp33bb6	420	24	of	of	IN
cord-018265-twp33bb6	420	25	acellular	acellular	JJ
cord-018265-twp33bb6	420	26	vaccines	vaccine	NNS
cord-018265-twp33bb6	420	27	against	against	IN
cord-018265-twp33bb6	420	28	microorganisms	microorganism	NNS
cord-018265-twp33bb6	420	29	,	,	,
cord-018265-twp33bb6	420	30	such	such	JJ
cord-018265-twp33bb6	420	31	as	as	IN
cord-018265-twp33bb6	420	32	S.	S.	NNP
cord-018265-twp33bb6	420	33	pneumonia	pneumonia	NN
cord-018265-twp33bb6	420	34	and	and	CC
cord-018265-twp33bb6	420	35	H.	h.	NN
cord-018265-twp33bb6	420	36	influenzae	influenzae	NN
cord-018265-twp33bb6	420	37	[	[	-LRB-
cord-018265-twp33bb6	420	38	171	171	CD
cord-018265-twp33bb6	420	39	,	,	,
cord-018265-twp33bb6	420	40	172	172	CD
cord-018265-twp33bb6	420	41	]	]	-RRB-
cord-018265-twp33bb6	420	42	.	.	.
cord-018265-twp33bb6	421	1	Other	other	JJ
cord-018265-twp33bb6	421	2	bacterial	bacterial	JJ
cord-018265-twp33bb6	421	3	components	component	NNS
cord-018265-twp33bb6	421	4	were	be	VBD
cord-018265-twp33bb6	421	5	also	also	RB
cord-018265-twp33bb6	421	6	explored	explore	VBN
cord-018265-twp33bb6	421	7	for	for	IN
cord-018265-twp33bb6	421	8	their	-PRON-	PRP$
cord-018265-twp33bb6	421	9	activity	activity	NN
cord-018265-twp33bb6	421	10	as	as	IN
cord-018265-twp33bb6	421	11	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	421	12	.	.	.
cord-018265-twp33bb6	422	1	The	the	DT
cord-018265-twp33bb6	422	2	monophosphoryl	monophosphoryl	NNP
cord-018265-twp33bb6	422	3	lipid	lipid	VBG
cord-018265-twp33bb6	422	4	A	A	NNP
cord-018265-twp33bb6	422	5	retains	retain	VBZ
cord-018265-twp33bb6	422	6	much	much	JJ
cord-018265-twp33bb6	422	7	of	of	IN
cord-018265-twp33bb6	422	8	the	the	DT
cord-018265-twp33bb6	422	9	immune	immune	JJ
cord-018265-twp33bb6	422	10	stimulatory	stimulatory	JJ
cord-018265-twp33bb6	422	11	properties	property	NNS
cord-018265-twp33bb6	422	12	of	of	IN
cord-018265-twp33bb6	422	13	LPS	LPS	NNP
cord-018265-twp33bb6	422	14	,	,	,
cord-018265-twp33bb6	422	15	without	without	IN
cord-018265-twp33bb6	422	16	the	the	DT
cord-018265-twp33bb6	422	17	inherent	inherent	JJ
cord-018265-twp33bb6	422	18	toxicity	toxicity	NN
cord-018265-twp33bb6	422	19	[	[	-LRB-
cord-018265-twp33bb6	422	20	165	165	CD
cord-018265-twp33bb6	422	21	]	]	-RRB-
cord-018265-twp33bb6	422	22	.	.	.
cord-018265-twp33bb6	423	1	On	on	IN
cord-018265-twp33bb6	423	2	the	the	DT
cord-018265-twp33bb6	423	3	other	other	JJ
cord-018265-twp33bb6	423	4	hand	hand	NN
cord-018265-twp33bb6	423	5	,	,	,
cord-018265-twp33bb6	423	6	extracellular	extracellular	JJ
cord-018265-twp33bb6	423	7	matrix	matrix	NN
cord-018265-twp33bb6	423	8	binding	bind	VBG
cord-018265-twp33bb6	423	9	proteins	protein	NNS
cord-018265-twp33bb6	423	10	,	,	,
cord-018265-twp33bb6	423	11	such	such	JJ
cord-018265-twp33bb6	423	12	as	as	IN
cord-018265-twp33bb6	423	13	the	the	DT
cord-018265-twp33bb6	423	14	fibronectin	fibronectin	NN
cord-018265-twp33bb6	423	15	binding	bind	VBG
cord-018265-twp33bb6	423	16	protein	protein	NN
cord-018265-twp33bb6	423	17	I	-PRON-	PRP
cord-018265-twp33bb6	423	18	of	of	IN
cord-018265-twp33bb6	423	19	Streptococcus	streptococcus	NN
cord-018265-twp33bb6	423	20	pyogenes	pyogene	NNS
cord-018265-twp33bb6	423	21	,	,	,
cord-018265-twp33bb6	423	22	also	also	RB
cord-018265-twp33bb6	423	23	exhibit	exhibit	VB
cord-018265-twp33bb6	423	24	adjuvant	adjuvant	JJ
cord-018265-twp33bb6	423	25	activity	activity	NN
cord-018265-twp33bb6	423	26	[	[	-LRB-
cord-018265-twp33bb6	423	27	173	173	CD
cord-018265-twp33bb6	423	28	]	]	-RRB-
cord-018265-twp33bb6	423	29	.	.	.
cord-018265-twp33bb6	424	1	This	this	DT
cord-018265-twp33bb6	424	2	offers	offer	VBZ
cord-018265-twp33bb6	424	3	the	the	DT
cord-018265-twp33bb6	424	4	possibility	possibility	NN
cord-018265-twp33bb6	424	5	of	of	IN
cord-018265-twp33bb6	424	6	using	use	VBG
cord-018265-twp33bb6	424	7	them	-PRON-	PRP
cord-018265-twp33bb6	424	8	as	as	IN
cord-018265-twp33bb6	424	9	dual	dual	JJ
cord-018265-twp33bb6	424	10	antigen	antigen	NN
cord-018265-twp33bb6	424	11	/	/	SYM
cord-018265-twp33bb6	424	12	adjuvant	adjuvant	NN
cord-018265-twp33bb6	424	13	moieties	moiety	NNS
cord-018265-twp33bb6	424	14	in	in	IN
cord-018265-twp33bb6	424	15	the	the	DT
cord-018265-twp33bb6	424	16	same	same	JJ
cord-018265-twp33bb6	424	17	formulation	formulation	NN
cord-018265-twp33bb6	424	18	.	.	.
cord-018265-twp33bb6	425	1	Recent	recent	JJ
cord-018265-twp33bb6	425	2	reports	report	NNS
cord-018265-twp33bb6	425	3	also	also	RB
cord-018265-twp33bb6	425	4	demonstrate	demonstrate	VBP
cord-018265-twp33bb6	425	5	that	that	IN
cord-018265-twp33bb6	425	6	vaccine	vaccine	NN
cord-018265-twp33bb6	425	7	formulations	formulation	NNS
cord-018265-twp33bb6	425	8	containing	contain	VBG
cord-018265-twp33bb6	425	9	adamantylamide	adamantylamide	IN
cord-018265-twp33bb6	425	10	dipeptide	dipeptide	NNP
cord-018265-twp33bb6	425	11	,	,	,
cord-018265-twp33bb6	425	12	a	a	DT
cord-018265-twp33bb6	425	13	non	non	JJ
cord-018265-twp33bb6	425	14	-	-	JJ
cord-018265-twp33bb6	425	15	toxic	toxic	JJ
cord-018265-twp33bb6	425	16	compound	compound	NN
cord-018265-twp33bb6	425	17	obtained	obtain	VBN
cord-018265-twp33bb6	425	18	by	by	IN
cord-018265-twp33bb6	425	19	linking	link	VBG
cord-018265-twp33bb6	425	20	the	the	DT
cord-018265-twp33bb6	425	21	L	L	NNP
cord-018265-twp33bb6	425	22	-	-	HYPH
cord-018265-twp33bb6	425	23	alanine	alanine	NN
cord-018265-twp33bb6	425	24	-	-	HYPH
cord-018265-twp33bb6	425	25	D	d	NN
cord-018265-twp33bb6	425	26	-	-	HYPH
cord-018265-twp33bb6	425	27	isoglutamine	isoglutamine	JJ
cord-018265-twp33bb6	425	28	residue	residue	NN
cord-018265-twp33bb6	425	29	of	of	IN
cord-018265-twp33bb6	425	30	the	the	DT
cord-018265-twp33bb6	425	31	muramyl	muramyl	NN
cord-018265-twp33bb6	425	32	dipeptide	dipeptide	NNP
cord-018265-twp33bb6	425	33	to	to	IN
cord-018265-twp33bb6	425	34	the	the	DT
cord-018265-twp33bb6	425	35	antiviral	antiviral	JJ
cord-018265-twp33bb6	425	36	drug	drug	NN
cord-018265-twp33bb6	425	37	amantadine	amantadine	NNP
cord-018265-twp33bb6	425	38	,	,	,
cord-018265-twp33bb6	425	39	confer	confer	VB
cord-018265-twp33bb6	425	40	protection	protection	NN
cord-018265-twp33bb6	425	41	against	against	IN
cord-018265-twp33bb6	425	42	non	non	JJ
cord-018265-twp33bb6	425	43	typeable	typeable	JJ
cord-018265-twp33bb6	425	44	H.	h.	NN
cord-018265-twp33bb6	425	45	influenzae	influenzae	NN
cord-018265-twp33bb6	425	46	in	in	IN
cord-018265-twp33bb6	425	47	preclinical	preclinical	JJ
cord-018265-twp33bb6	425	48	models	model	NNS
cord-018265-twp33bb6	425	49	[	[	-LRB-
cord-018265-twp33bb6	425	50	73	73	CD
cord-018265-twp33bb6	425	51	]	]	-RRB-
cord-018265-twp33bb6	425	52	.	.	.
cord-018265-twp33bb6	426	1	The	the	DT
cord-018265-twp33bb6	426	2	innate	innate	JJ
cord-018265-twp33bb6	426	3	immune	immune	JJ
cord-018265-twp33bb6	426	4	system	system	NN
cord-018265-twp33bb6	426	5	plays	play	VBZ
cord-018265-twp33bb6	426	6	a	a	DT
cord-018265-twp33bb6	426	7	critical	critical	JJ
cord-018265-twp33bb6	426	8	early	early	JJ
cord-018265-twp33bb6	426	9	role	role	NN
cord-018265-twp33bb6	426	10	in	in	IN
cord-018265-twp33bb6	426	11	host	host	NN
cord-018265-twp33bb6	426	12	defence	defence	NN
cord-018265-twp33bb6	426	13	against	against	IN
cord-018265-twp33bb6	426	14	pathogenic	pathogenic	JJ
cord-018265-twp33bb6	426	15	microorganisms	microorganism	NNS
cord-018265-twp33bb6	426	16	through	through	IN
cord-018265-twp33bb6	426	17	the	the	DT
cord-018265-twp33bb6	426	18	recognition	recognition	NN
cord-018265-twp33bb6	426	19	of	of	IN
cord-018265-twp33bb6	426	20	pathogenassociated	pathogenassociate	VBN
cord-018265-twp33bb6	426	21	molecular	molecular	JJ
cord-018265-twp33bb6	426	22	patterns	pattern	NNS
cord-018265-twp33bb6	426	23	[	[	-LRB-
cord-018265-twp33bb6	426	24	174	174	CD
cord-018265-twp33bb6	426	25	]	]	-RRB-
cord-018265-twp33bb6	426	26	.	.	.
cord-018265-twp33bb6	427	1	This	this	DT
cord-018265-twp33bb6	427	2	is	be	VBZ
cord-018265-twp33bb6	427	3	achieved	achieve	VBN
cord-018265-twp33bb6	427	4	through	through	IN
cord-018265-twp33bb6	427	5	the	the	DT
cord-018265-twp33bb6	427	6	stimulation	stimulation	NN
cord-018265-twp33bb6	427	7	of	of	IN
cord-018265-twp33bb6	427	8	pattern	pattern	NN
cord-018265-twp33bb6	427	9	-	-	HYPH
cord-018265-twp33bb6	427	10	recognition	recognition	NN
cord-018265-twp33bb6	427	11	receptors	receptor	NNS
cord-018265-twp33bb6	427	12	(	(	-LRB-
cord-018265-twp33bb6	427	13	PRR	PRR	NNP
cord-018265-twp33bb6	427	14	)	)	-RRB-
cord-018265-twp33bb6	427	15	that	that	WDT
cord-018265-twp33bb6	427	16	sense	sense	VBP
cord-018265-twp33bb6	427	17	a	a	DT
cord-018265-twp33bb6	427	18	broad	broad	JJ
cord-018265-twp33bb6	427	19	range	range	NN
cord-018265-twp33bb6	427	20	of	of	IN
cord-018265-twp33bb6	427	21	exogenous	exogenous	JJ
cord-018265-twp33bb6	427	22	and	and	CC
cord-018265-twp33bb6	427	23	endogenous	endogenous	JJ
cord-018265-twp33bb6	427	24	danger	danger	NN
cord-018265-twp33bb6	427	25	signals	signal	NNS
cord-018265-twp33bb6	427	26	[	[	-LRB-
cord-018265-twp33bb6	427	27	153	153	CD
cord-018265-twp33bb6	427	28	,	,	,
cord-018265-twp33bb6	427	29	174	174	CD
cord-018265-twp33bb6	427	30	]	]	-RRB-
cord-018265-twp33bb6	427	31	.	.	.
cord-018265-twp33bb6	428	1	Toll	toll	NN
cord-018265-twp33bb6	428	2	-	-	HYPH
cord-018265-twp33bb6	428	3	like	like	JJ
cord-018265-twp33bb6	428	4	receptors	receptor	NNS
cord-018265-twp33bb6	428	5	(	(	-LRB-
cord-018265-twp33bb6	428	6	TLR	TLR	NNP
cord-018265-twp33bb6	428	7	)	)	-RRB-
cord-018265-twp33bb6	428	8	represent	represent	VBP
cord-018265-twp33bb6	428	9	the	the	DT
cord-018265-twp33bb6	428	10	best	well	RBS
cord-018265-twp33bb6	428	11	-	-	HYPH
cord-018265-twp33bb6	428	12	characterized	characterize	VBN
cord-018265-twp33bb6	428	13	family	family	NN
cord-018265-twp33bb6	428	14	of	of	IN
cord-018265-twp33bb6	428	15	PRR	PRR	NNP
cord-018265-twp33bb6	428	16	.	.	.
cord-018265-twp33bb6	429	1	Natural	natural	JJ
cord-018265-twp33bb6	429	2	and	and	CC
cord-018265-twp33bb6	429	3	synthetic	synthetic	JJ
cord-018265-twp33bb6	429	4	TLR	TLR	NNP
cord-018265-twp33bb6	429	5	agonists	agonist	NNS
cord-018265-twp33bb6	429	6	are	be	VBP
cord-018265-twp33bb6	429	7	being	be	VBG
cord-018265-twp33bb6	429	8	used	use	VBN
cord-018265-twp33bb6	429	9	as	as	IN
cord-018265-twp33bb6	429	10	immune	immune	JJ
cord-018265-twp33bb6	429	11	modulators	modulator	NNS
cord-018265-twp33bb6	429	12	to	to	TO
cord-018265-twp33bb6	429	13	optimize	optimize	VB
cord-018265-twp33bb6	429	14	responses	response	NNS
cord-018265-twp33bb6	429	15	after	after	IN
cord-018265-twp33bb6	429	16	vaccination	vaccination	NN
cord-018265-twp33bb6	429	17	.	.	.
cord-018265-twp33bb6	430	1	Since	since	IN
cord-018265-twp33bb6	430	2	the	the	DT
cord-018265-twp33bb6	430	3	identification	identification	NN
cord-018265-twp33bb6	430	4	of	of	IN
cord-018265-twp33bb6	430	5	the	the	DT
cord-018265-twp33bb6	430	6	TLR4	TLR4	NNP
cord-018265-twp33bb6	430	7	,	,	,
cord-018265-twp33bb6	430	8	many	many	JJ
cord-018265-twp33bb6	430	9	mammalian	mammalian	JJ
cord-018265-twp33bb6	430	10	TLR	TLR	NNP
cord-018265-twp33bb6	430	11	homologues	homologue	NNS
cord-018265-twp33bb6	430	12	have	have	VBP
cord-018265-twp33bb6	430	13	been	be	VBN
cord-018265-twp33bb6	430	14	identified	identify	VBN
cord-018265-twp33bb6	430	15	(	(	-LRB-
cord-018265-twp33bb6	430	16	i.e.	i.e.	FW
cord-018265-twp33bb6	430	17	,	,	,
cord-018265-twp33bb6	430	18	10	10	CD
cord-018265-twp33bb6	430	19	in	in	IN
cord-018265-twp33bb6	430	20	humans	human	NNS
cord-018265-twp33bb6	430	21	and	and	CC
cord-018265-twp33bb6	430	22	13	13	CD
cord-018265-twp33bb6	430	23	in	in	IN
cord-018265-twp33bb6	430	24	mice	mouse	NNS
cord-018265-twp33bb6	430	25	)	)	-RRB-
cord-018265-twp33bb6	430	26	[	[	-LRB-
cord-018265-twp33bb6	430	27	175	175	CD
cord-018265-twp33bb6	430	28	]	]	-RRB-
cord-018265-twp33bb6	430	29	.	.	.
cord-018265-twp33bb6	431	1	Each	each	DT
cord-018265-twp33bb6	431	2	TLR	TLR	NNP
cord-018265-twp33bb6	431	3	member	member	NN
cord-018265-twp33bb6	431	4	binds	bind	VBZ
cord-018265-twp33bb6	431	5	specifically	specifically	RB
cord-018265-twp33bb6	431	6	to	to	IN
cord-018265-twp33bb6	431	7	different	different	JJ
cord-018265-twp33bb6	431	8	ligands	ligand	NNS
cord-018265-twp33bb6	431	9	(	(	-LRB-
cord-018265-twp33bb6	431	10	Tab	Tab	NNP
cord-018265-twp33bb6	431	11	.	.	.
cord-018265-twp33bb6	431	12	2	2	LS
cord-018265-twp33bb6	431	13	)	)	-RRB-
cord-018265-twp33bb6	431	14	,	,	,
cord-018265-twp33bb6	431	15	alone	alone	JJ
cord-018265-twp33bb6	431	16	or	or	CC
cord-018265-twp33bb6	431	17	in	in	IN
cord-018265-twp33bb6	431	18	combinations	combination	NNS
cord-018265-twp33bb6	431	19	(	(	-LRB-
cord-018265-twp33bb6	431	20	e.g.	e.g.	RB
cord-018265-twp33bb6	431	21	,	,	,
cord-018265-twp33bb6	431	22	heterodimers	heterodimer	NNS
cord-018265-twp33bb6	431	23	formed	form	VBN
cord-018265-twp33bb6	431	24	by	by	IN
cord-018265-twp33bb6	431	25	TLR2	TLR2	NNP
cord-018265-twp33bb6	431	26	with	with	IN
cord-018265-twp33bb6	431	27	either	either	DT
cord-018265-twp33bb6	431	28	TLR1	TLR1	NNP
cord-018265-twp33bb6	431	29	or	or	CC
cord-018265-twp33bb6	431	30	TLR6	TLR6	NNP
cord-018265-twp33bb6	431	31	)	)	-RRB-
cord-018265-twp33bb6	431	32	.	.	.
cord-018265-twp33bb6	432	1	An	an	DT
cord-018265-twp33bb6	432	2	example	example	NN
cord-018265-twp33bb6	432	3	of	of	IN
cord-018265-twp33bb6	432	4	TLR	TLR	NNP
cord-018265-twp33bb6	432	5	agonist	agonist	NN
cord-018265-twp33bb6	432	6	is	be	VBZ
cord-018265-twp33bb6	432	7	bacterial	bacterial	JJ
cord-018265-twp33bb6	432	8	DNA	dna	NN
cord-018265-twp33bb6	432	9	,	,	,
cord-018265-twp33bb6	432	10	but	but	CC
cord-018265-twp33bb6	432	11	not	not	RB
cord-018265-twp33bb6	432	12	vertebrate	vertebrate	JJ
cord-018265-twp33bb6	432	13	DNA	dna	NN
cord-018265-twp33bb6	432	14	,	,	,
cord-018265-twp33bb6	432	15	and	and	CC
cord-018265-twp33bb6	432	16	synthetic	synthetic	JJ
cord-018265-twp33bb6	432	17	oligodeoxynucleotides	oligodeoxynucleotide	NNS
cord-018265-twp33bb6	432	18	containing	contain	VBG
cord-018265-twp33bb6	432	19	unmethylated	unmethylate	VBN
cord-018265-twp33bb6	432	20	CpG	CpG	NNP
cord-018265-twp33bb6	432	21	motifs	motif	NNS
cord-018265-twp33bb6	432	22	.	.	.
cord-018265-twp33bb6	433	1	They	-PRON-	PRP
cord-018265-twp33bb6	433	2	act	act	VBP
cord-018265-twp33bb6	433	3	on	on	IN
cord-018265-twp33bb6	433	4	TLR9	TLR9	NNP
cord-018265-twp33bb6	433	5	,	,	,
cord-018265-twp33bb6	433	6	thereby	thereby	RB
cord-018265-twp33bb6	433	7	inducing	induce	VBG
cord-018265-twp33bb6	433	8	a	a	DT
cord-018265-twp33bb6	433	9	strong	strong	JJ
cord-018265-twp33bb6	433	10	Th1	th1	CD
cord-018265-twp33bb6	433	11	responses	response	NNS
cord-018265-twp33bb6	433	12	by	by	IN
cord-018265-twp33bb6	433	13	activation	activation	NN
cord-018265-twp33bb6	433	14	of	of	IN
cord-018265-twp33bb6	433	15	dendritic	dendritic	JJ
cord-018265-twp33bb6	433	16	cells	cell	NNS
cord-018265-twp33bb6	433	17	[	[	-LRB-
cord-018265-twp33bb6	433	18	176	176	CD
cord-018265-twp33bb6	433	19	,	,	,
cord-018265-twp33bb6	433	20	177	177	CD
cord-018265-twp33bb6	433	21	]	]	-RRB-
cord-018265-twp33bb6	433	22	.	.	.
cord-018265-twp33bb6	434	1	CpG	CpG	NNP
cord-018265-twp33bb6	434	2	motifs	motif	NNS
cord-018265-twp33bb6	434	3	have	have	VBP
cord-018265-twp33bb6	434	4	been	be	VBN
cord-018265-twp33bb6	434	5	successfully	successfully	RB
cord-018265-twp33bb6	434	6	used	use	VBN
cord-018265-twp33bb6	434	7	as	as	IN
cord-018265-twp33bb6	434	8	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	434	9	in	in	IN
cord-018265-twp33bb6	434	10	preclinical	preclinical	JJ
cord-018265-twp33bb6	434	11	studies	study	NNS
cord-018265-twp33bb6	434	12	of	of	IN
cord-018265-twp33bb6	434	13	different	different	JJ
cord-018265-twp33bb6	434	14	candidate	candidate	NN
cord-018265-twp33bb6	434	15	vaccines	vaccine	NNS
cord-018265-twp33bb6	434	16	against	against	IN
cord-018265-twp33bb6	434	17	agents	agent	NNS
cord-018265-twp33bb6	434	18	causing	cause	VBG
cord-018265-twp33bb6	434	19	community	community	NN
cord-018265-twp33bb6	434	20	-	-	HYPH
cord-018265-twp33bb6	434	21	acquired	acquire	VBN
cord-018265-twp33bb6	434	22	pneumonia	pneumonia	NN
cord-018265-twp33bb6	434	23	[	[	-LRB-
cord-018265-twp33bb6	434	24	178	178	CD
cord-018265-twp33bb6	434	25	]	]	-RRB-
cord-018265-twp33bb6	434	26	[	[	-LRB-
cord-018265-twp33bb6	434	27	179	179	CD
cord-018265-twp33bb6	434	28	]	]	-RRB-
cord-018265-twp33bb6	434	29	[	[	-LRB-
cord-018265-twp33bb6	434	30	180	180	CD
cord-018265-twp33bb6	434	31	]	]	-RRB-
cord-018265-twp33bb6	434	32	.	.	.
cord-018265-twp33bb6	435	1	Another	another	DT
cord-018265-twp33bb6	435	2	important	important	JJ
cord-018265-twp33bb6	435	3	adjuvant	adjuvant	NN
cord-018265-twp33bb6	435	4	with	with	IN
cord-018265-twp33bb6	435	5	TLR	tlr	NN
cord-018265-twp33bb6	435	6	-	-	HYPH
cord-018265-twp33bb6	435	7	binding	bind	VBG
cord-018265-twp33bb6	435	8	capacities	capacity	NNS
cord-018265-twp33bb6	435	9	is	be	VBZ
cord-018265-twp33bb6	435	10	the	the	DT
cord-018265-twp33bb6	435	11	Mycoplasma	Mycoplasma	NNP
cord-018265-twp33bb6	435	12	-	-	HYPH
cord-018265-twp33bb6	435	13	derived	derive	VBN
cord-018265-twp33bb6	435	14	macrophage	macrophage	NN
cord-018265-twp33bb6	435	15	-	-	HYPH
cord-018265-twp33bb6	435	16	activating	activate	VBG
cord-018265-twp33bb6	435	17	lipopeptide	lipopeptide	JJ
cord-018265-twp33bb6	435	18	MALP-2	MALP-2	NNP
cord-018265-twp33bb6	435	19	,	,	,
cord-018265-twp33bb6	435	20	which	which	WDT
cord-018265-twp33bb6	435	21	act	act	VBP
cord-018265-twp33bb6	435	22	a	a	DT
cord-018265-twp33bb6	435	23	the	the	DT
cord-018265-twp33bb6	435	24	level	level	NN
cord-018265-twp33bb6	435	25	of	of	IN
cord-018265-twp33bb6	435	26	the	the	DT
cord-018265-twp33bb6	435	27	TLR	TLR	NNP
cord-018265-twp33bb6	435	28	heterodimer	heterodimer	NN
cord-018265-twp33bb6	435	29	2/6	2/6	CD
cord-018265-twp33bb6	435	30	[	[	-LRB-
cord-018265-twp33bb6	435	31	181	181	CD
cord-018265-twp33bb6	435	32	,	,	,
cord-018265-twp33bb6	435	33	182	182	CD
cord-018265-twp33bb6	435	34	]	]	-RRB-
cord-018265-twp33bb6	435	35	.	.	.
cord-018265-twp33bb6	436	1	MALP-2	MALP-2	NNP
cord-018265-twp33bb6	436	2	promotes	promote	VBZ
cord-018265-twp33bb6	436	3	a	a	DT
cord-018265-twp33bb6	436	4	global	global	JJ
cord-018265-twp33bb6	436	5	activation	activation	NN
cord-018265-twp33bb6	436	6	of	of	IN
cord-018265-twp33bb6	436	7	cells	cell	NNS
cord-018265-twp33bb6	436	8	from	from	IN
cord-018265-twp33bb6	436	9	the	the	DT
cord-018265-twp33bb6	436	10	innate	innate	JJ
cord-018265-twp33bb6	436	11	and	and	CC
cord-018265-twp33bb6	436	12	adaptive	adaptive	JJ
cord-018265-twp33bb6	436	13	immune	immune	JJ
cord-018265-twp33bb6	436	14	system	system	NN
cord-018265-twp33bb6	436	15	[	[	-LRB-
cord-018265-twp33bb6	436	16	183	183	CD
cord-018265-twp33bb6	436	17	,	,	,
cord-018265-twp33bb6	436	18	184	184	CD
cord-018265-twp33bb6	436	19	]	]	-RRB-
cord-018265-twp33bb6	436	20	,	,	,
cord-018265-twp33bb6	436	21	such	such	JJ
cord-018265-twp33bb6	436	22	as	as	IN
cord-018265-twp33bb6	436	23	macrophages	macrophage	NNS
cord-018265-twp33bb6	436	24	,	,	,
cord-018265-twp33bb6	436	25	DC	DC	NNP
cord-018265-twp33bb6	436	26	,	,	,
cord-018265-twp33bb6	436	27	T	T	NNP
cord-018265-twp33bb6	436	28	-	-	HYPH
cord-018265-twp33bb6	436	29	and	and	CC
cord-018265-twp33bb6	436	30	B	b	NN
cord-018265-twp33bb6	436	31	-	-	HYPH
cord-018265-twp33bb6	436	32	lymphocytes	lymphocyte	NNS
cord-018265-twp33bb6	436	33	[	[	-LRB-
cord-018265-twp33bb6	436	34	183	183	CD
cord-018265-twp33bb6	436	35	,	,	,
cord-018265-twp33bb6	436	36	185	185	CD
cord-018265-twp33bb6	436	37	]	]	-RRB-
cord-018265-twp33bb6	436	38	.	.	.
cord-018265-twp33bb6	437	1	When	when	WRB
cord-018265-twp33bb6	437	2	coadministered	coadministere	VBN
cord-018265-twp33bb6	437	3	with	with	IN
cord-018265-twp33bb6	437	4	an	an	DT
cord-018265-twp33bb6	437	5	antigen	antigen	NN
cord-018265-twp33bb6	437	6	by	by	IN
cord-018265-twp33bb6	437	7	either	either	CC
cord-018265-twp33bb6	437	8	the	the	DT
cord-018265-twp33bb6	437	9	parenteral	parenteral	JJ
cord-018265-twp33bb6	437	10	or	or	CC
cord-018265-twp33bb6	437	11	the	the	DT
cord-018265-twp33bb6	437	12	mucosal	mucosal	JJ
cord-018265-twp33bb6	437	13	route	route	NN
cord-018265-twp33bb6	437	14	,	,	,
cord-018265-twp33bb6	437	15	MALP-2	MALP-2	NNP
cord-018265-twp33bb6	437	16	promotes	promote	VBZ
cord-018265-twp33bb6	437	17	the	the	DT
cord-018265-twp33bb6	437	18	elicitation	elicitation	NN
cord-018265-twp33bb6	437	19	of	of	IN
cord-018265-twp33bb6	437	20	humoral	humoral	JJ
cord-018265-twp33bb6	437	21	and	and	CC
cord-018265-twp33bb6	437	22	cellular	cellular	JJ
cord-018265-twp33bb6	437	23	responses	response	NNS
cord-018265-twp33bb6	437	24	at	at	IN
cord-018265-twp33bb6	437	25	systemic	systemic	JJ
cord-018265-twp33bb6	437	26	and	and	CC
cord-018265-twp33bb6	437	27	mucosal	mucosal	JJ
cord-018265-twp33bb6	437	28	level	level	NN
cord-018265-twp33bb6	437	29	[	[	-LRB-
cord-018265-twp33bb6	437	30	186	186	CD
cord-018265-twp33bb6	437	31	]	]	-RRB-
cord-018265-twp33bb6	437	32	.	.	.
cord-018265-twp33bb6	438	1	Preclinical	preclinical	JJ
cord-018265-twp33bb6	438	2	studies	study	NNS
cord-018265-twp33bb6	438	3	suggested	suggest	VBD
cord-018265-twp33bb6	438	4	that	that	IN
cord-018265-twp33bb6	438	5	MALP-2	MALP-2	NNP
cord-018265-twp33bb6	438	6	could	could	MD
cord-018265-twp33bb6	438	7	be	be	VB
cord-018265-twp33bb6	438	8	exploited	exploit	VBN
cord-018265-twp33bb6	438	9	in	in	IN
cord-018265-twp33bb6	438	10	vaccine	vaccine	NN
cord-018265-twp33bb6	438	11	formulations	formulation	NNS
cord-018265-twp33bb6	438	12	against	against	IN
cord-018265-twp33bb6	438	13	the	the	DT
cord-018265-twp33bb6	438	14	SARS	SARS	NNP
cord-018265-twp33bb6	438	15	-	-	HYPH
cord-018265-twp33bb6	438	16	associated	associate	VBN
cord-018265-twp33bb6	438	17	coronavirus	coronavirus	NN
cord-018265-twp33bb6	438	18	,	,	,
cord-018265-twp33bb6	438	19	M.	M.	NNP
cord-018265-twp33bb6	438	20	catarrhalis	catarrhalis	NNP
cord-018265-twp33bb6	438	21	and	and	CC
cord-018265-twp33bb6	438	22	influenza	influenza	NN
cord-018265-twp33bb6	438	23	virus	virus	NN
cord-018265-twp33bb6	438	24	,	,	,
cord-018265-twp33bb6	438	25	among	among	IN
cord-018265-twp33bb6	438	26	others	other	NNS
cord-018265-twp33bb6	438	27	(	(	-LRB-
cord-018265-twp33bb6	438	28	unpublished	unpublished	JJ
cord-018265-twp33bb6	438	29	data	datum	NNS
cord-018265-twp33bb6	438	30	)	)	-RRB-
cord-018265-twp33bb6	438	31	.	.	.
cord-018265-twp33bb6	438	32	 	 	_SP
cord-018265-twp33bb6	439	1	DNA	DNA	NNP
cord-018265-twp33bb6	439	2	vaccination	vaccination	NN
cord-018265-twp33bb6	439	3	offers	offer	VBZ
cord-018265-twp33bb6	439	4	some	some	DT
cord-018265-twp33bb6	439	5	advantage	advantage	NN
cord-018265-twp33bb6	439	6	over	over	IN
cord-018265-twp33bb6	439	7	the	the	DT
cord-018265-twp33bb6	439	8	normal	normal	JJ
cord-018265-twp33bb6	439	9	antigen	antigen	NN
cord-018265-twp33bb6	439	10	vaccination	vaccination	NN
cord-018265-twp33bb6	439	11	,	,	,
cord-018265-twp33bb6	439	12	such	such	JJ
cord-018265-twp33bb6	439	13	as	as	IN
cord-018265-twp33bb6	439	14	the	the	DT
cord-018265-twp33bb6	439	15	fact	fact	NN
cord-018265-twp33bb6	439	16	that	that	IN
cord-018265-twp33bb6	439	17	it	-PRON-	PRP
cord-018265-twp33bb6	439	18	is	be	VBZ
cord-018265-twp33bb6	439	19	not	not	RB
cord-018265-twp33bb6	439	20	necessary	necessary	JJ
cord-018265-twp33bb6	439	21	to	to	TO
cord-018265-twp33bb6	439	22	express	express	VB
cord-018265-twp33bb6	439	23	any	any	DT
cord-018265-twp33bb6	439	24	antigen	antigen	NN
cord-018265-twp33bb6	439	25	.	.	.
cord-018265-twp33bb6	440	1	In	in	IN
cord-018265-twp33bb6	440	2	contrast	contrast	NN
cord-018265-twp33bb6	440	3	,	,	,
cord-018265-twp33bb6	440	4	it	-PRON-	PRP
cord-018265-twp33bb6	440	5	is	be	VBZ
cord-018265-twp33bb6	440	6	the	the	DT
cord-018265-twp33bb6	440	7	biosynthetic	biosynthetic	JJ
cord-018265-twp33bb6	440	8	machinery	machinery	NN
cord-018265-twp33bb6	440	9	present	present	JJ
cord-018265-twp33bb6	440	10	in	in	IN
cord-018265-twp33bb6	440	11	the	the	DT
cord-018265-twp33bb6	440	12	cells	cell	NNS
cord-018265-twp33bb6	440	13	of	of	IN
cord-018265-twp33bb6	440	14	the	the	DT
cord-018265-twp33bb6	440	15	vaccinees	vaccinee	NNS
cord-018265-twp33bb6	440	16	that	that	WDT
cord-018265-twp33bb6	440	17	takes	take	VBZ
cord-018265-twp33bb6	440	18	care	care	NN
cord-018265-twp33bb6	440	19	of	of	IN
cord-018265-twp33bb6	440	20	this	this	DT
cord-018265-twp33bb6	440	21	work	work	NN
cord-018265-twp33bb6	440	22	.	.	.
cord-018265-twp33bb6	441	1	Furthermore	furthermore	RB
cord-018265-twp33bb6	441	2	,	,	,
cord-018265-twp33bb6	441	3	since	since	IN
cord-018265-twp33bb6	441	4	eukaryotic	eukaryotic	JJ
cord-018265-twp33bb6	441	5	cells	cell	NNS
cord-018265-twp33bb6	441	6	are	be	VBP
cord-018265-twp33bb6	441	7	in	in	IN
cord-018265-twp33bb6	441	8	charge	charge	NN
cord-018265-twp33bb6	441	9	of	of	IN
cord-018265-twp33bb6	441	10	protein	protein	NN
cord-018265-twp33bb6	441	11	synthesis	synthesis	NN
cord-018265-twp33bb6	441	12	,	,	,
cord-018265-twp33bb6	441	13	their	-PRON-	PRP$
cord-018265-twp33bb6	441	14	glycosylation	glycosylation	NN
cord-018265-twp33bb6	441	15	and	and	CC
cord-018265-twp33bb6	441	16	folding	folding	NN
cord-018265-twp33bb6	441	17	are	be	VBP
cord-018265-twp33bb6	441	18	optimal	optimal	JJ
cord-018265-twp33bb6	441	19	.	.	.
cord-018265-twp33bb6	442	1	However	however	RB
cord-018265-twp33bb6	442	2	,	,	,
cord-018265-twp33bb6	442	3	the	the	DT
cord-018265-twp33bb6	442	4	large	large	JJ
cord-018265-twp33bb6	442	5	-	-	HYPH
cord-018265-twp33bb6	442	6	scale	scale	NN
cord-018265-twp33bb6	442	7	purification	purification	NN
cord-018265-twp33bb6	442	8	of	of	IN
cord-018265-twp33bb6	442	9	DNA	DNA	NNP
cord-018265-twp33bb6	442	10	might	may	MD
cord-018265-twp33bb6	442	11	be	be	VB
cord-018265-twp33bb6	442	12	associated	associate	VBN
cord-018265-twp33bb6	442	13	with	with	IN
cord-018265-twp33bb6	442	14	high	high	JJ
cord-018265-twp33bb6	442	15	costs	cost	NNS
cord-018265-twp33bb6	442	16	.	.	.
cord-018265-twp33bb6	443	1	This	this	DT
cord-018265-twp33bb6	443	2	can	can	MD
cord-018265-twp33bb6	443	3	be	be	VB
cord-018265-twp33bb6	443	4	solved	solve	VBN
cord-018265-twp33bb6	443	5	by	by	IN
cord-018265-twp33bb6	443	6	the	the	DT
cord-018265-twp33bb6	443	7	use	use	NN
cord-018265-twp33bb6	443	8	of	of	IN
cord-018265-twp33bb6	443	9	attenuated	attenuated	JJ
cord-018265-twp33bb6	443	10	or	or	CC
cord-018265-twp33bb6	443	11	inactivated	inactivate	VBN
cord-018265-twp33bb6	443	12	bacteria	bacteria	NNS
cord-018265-twp33bb6	443	13	or	or	CC
cord-018265-twp33bb6	443	14	viruses	virus	NNS
cord-018265-twp33bb6	443	15	as	as	IN
cord-018265-twp33bb6	443	16	delivery	delivery	NN
cord-018265-twp33bb6	443	17	systems	system	NNS
cord-018265-twp33bb6	443	18	[	[	-LRB-
cord-018265-twp33bb6	443	19	187	187	CD
cord-018265-twp33bb6	443	20	]	]	-RRB-
cord-018265-twp33bb6	443	21	.	.	.
cord-018265-twp33bb6	444	1	This	this	DT
cord-018265-twp33bb6	444	2	approach	approach	NN
cord-018265-twp33bb6	444	3	can	can	MD
cord-018265-twp33bb6	444	4	also	also	RB
cord-018265-twp33bb6	444	5	lead	lead	VB
cord-018265-twp33bb6	444	6	to	to	IN
cord-018265-twp33bb6	444	7	an	an	DT
cord-018265-twp33bb6	444	8	enhanced	enhance	VBN
cord-018265-twp33bb6	444	9	induction	induction	NN
cord-018265-twp33bb6	444	10	of	of	IN
cord-018265-twp33bb6	444	11	antibodies	antibody	NNS
cord-018265-twp33bb6	444	12	,	,	,
cord-018265-twp33bb6	444	13	which	which	WDT
cord-018265-twp33bb6	444	14	is	be	VBZ
cord-018265-twp33bb6	444	15	otherwise	otherwise	RB
cord-018265-twp33bb6	444	16	poor	poor	JJ
cord-018265-twp33bb6	444	17	using	use	VBG
cord-018265-twp33bb6	444	18	conventional	conventional	JJ
cord-018265-twp33bb6	444	19	naked	naked	JJ
cord-018265-twp33bb6	444	20	DNA	dna	NN
cord-018265-twp33bb6	444	21	vaccines	vaccine	NNS
cord-018265-twp33bb6	444	22	.	.	.
cord-018265-twp33bb6	445	1	We	-PRON-	PRP
cord-018265-twp33bb6	445	2	have	have	VBP
cord-018265-twp33bb6	445	3	recently	recently	RB
cord-018265-twp33bb6	445	4	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	445	5	that	that	IN
cord-018265-twp33bb6	445	6	bacterial	bacterial	JJ
cord-018265-twp33bb6	445	7	ghosts	ghost	NNS
cord-018265-twp33bb6	445	8	can	can	MD
cord-018265-twp33bb6	445	9	be	be	VB
cord-018265-twp33bb6	445	10	also	also	RB
cord-018265-twp33bb6	445	11	exploited	exploit	VBN
cord-018265-twp33bb6	445	12	as	as	IN
cord-018265-twp33bb6	445	13	a	a	DT
cord-018265-twp33bb6	445	14	delivery	delivery	NN
cord-018265-twp33bb6	445	15	system	system	NN
cord-018265-twp33bb6	445	16	for	for	IN
cord-018265-twp33bb6	445	17	DNA	dna	NN
cord-018265-twp33bb6	445	18	vaccines	vaccine	NNS
cord-018265-twp33bb6	445	19	for	for	IN
cord-018265-twp33bb6	445	20	both	both	DT
cord-018265-twp33bb6	445	21	in	in	IN
cord-018265-twp33bb6	445	22	vivo	vivo	NNP
cord-018265-twp33bb6	445	23	and	and	CC
cord-018265-twp33bb6	445	24	ex	ex	FW
cord-018265-twp33bb6	445	25	vivo	vivo	NN
cord-018265-twp33bb6	445	26	applications	application	NNS
cord-018265-twp33bb6	445	27	[	[	-LRB-
cord-018265-twp33bb6	445	28	188	188	CD
cord-018265-twp33bb6	445	29	]	]	-RRB-
cord-018265-twp33bb6	445	30	.	.	.
cord-018265-twp33bb6	446	1	The	the	DT
cord-018265-twp33bb6	446	2	potential	potential	NN
cord-018265-twp33bb6	446	3	of	of	IN
cord-018265-twp33bb6	446	4	this	this	DT
cord-018265-twp33bb6	446	5	approach	approach	NN
cord-018265-twp33bb6	446	6	is	be	VBZ
cord-018265-twp33bb6	446	7	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	446	8	by	by	IN
cord-018265-twp33bb6	446	9	the	the	DT
cord-018265-twp33bb6	446	10	fact	fact	NN
cord-018265-twp33bb6	446	11	that	that	IN
cord-018265-twp33bb6	446	12	it	-PRON-	PRP
cord-018265-twp33bb6	446	13	is	be	VBZ
cord-018265-twp33bb6	446	14	possible	possible	JJ
cord-018265-twp33bb6	446	15	to	to	TO
cord-018265-twp33bb6	446	16	optimize	optimize	VB
cord-018265-twp33bb6	446	17	performance	performance	NN
cord-018265-twp33bb6	446	18	by	by	IN
cord-018265-twp33bb6	446	19	a	a	DT
cord-018265-twp33bb6	446	20	broad	broad	JJ
cord-018265-twp33bb6	446	21	range	range	NN
cord-018265-twp33bb6	446	22	of	of	IN
cord-018265-twp33bb6	446	23	manipulations	manipulation	NNS
cord-018265-twp33bb6	446	24	,	,	,
cord-018265-twp33bb6	446	25	such	such	JJ
cord-018265-twp33bb6	446	26	as	as	IN
cord-018265-twp33bb6	446	27	(	(	-LRB-
cord-018265-twp33bb6	446	28	i	i	NN
cord-018265-twp33bb6	446	29	)	)	-RRB-
cord-018265-twp33bb6	446	30	choice	choice	NN
cord-018265-twp33bb6	446	31	of	of	IN
cord-018265-twp33bb6	446	32	optimal	optimal	JJ
cord-018265-twp33bb6	446	33	promoters	promoter	NNS
cord-018265-twp33bb6	446	34	,	,	,
cord-018265-twp33bb6	446	35	(	(	-LRB-
cord-018265-twp33bb6	446	36	ii	ii	LS
cord-018265-twp33bb6	446	37	)	)	-RRB-
cord-018265-twp33bb6	446	38	use	use	NN
cord-018265-twp33bb6	446	39	of	of	IN
cord-018265-twp33bb6	446	40	codon	codon	NN
cord-018265-twp33bb6	446	41	optimized	optimize	VBN
cord-018265-twp33bb6	446	42	genes	gene	NNS
cord-018265-twp33bb6	446	43	for	for	IN
cord-018265-twp33bb6	446	44	expression	expression	NN
cord-018265-twp33bb6	446	45	in	in	IN
cord-018265-twp33bb6	446	46	mammalian	mammalian	JJ
cord-018265-twp33bb6	446	47	cells	cell	NNS
cord-018265-twp33bb6	446	48	,	,	,
cord-018265-twp33bb6	446	49	(	(	-LRB-
cord-018265-twp33bb6	446	50	iii	iii	NN
cord-018265-twp33bb6	446	51	)	)	-RRB-
cord-018265-twp33bb6	446	52	addition	addition	NN
cord-018265-twp33bb6	446	53	of	of	IN
cord-018265-twp33bb6	446	54	nuclear	nuclear	JJ
cord-018265-twp33bb6	446	55	localization	localization	NN
cord-018265-twp33bb6	446	56	signals	signal	NNS
cord-018265-twp33bb6	446	57	or	or	CC
cord-018265-twp33bb6	446	58	ubiquitination	ubiquitination	NN
cord-018265-twp33bb6	446	59	signals	signal	NNS
cord-018265-twp33bb6	446	60	to	to	TO
cord-018265-twp33bb6	446	61	improve	improve	VB
cord-018265-twp33bb6	446	62	expression	expression	NN
cord-018265-twp33bb6	446	63	and	and	CC
cord-018265-twp33bb6	446	64	processing	processing	NN
cord-018265-twp33bb6	446	65	,	,	,
cord-018265-twp33bb6	446	66	and	and	CC
cord-018265-twp33bb6	446	67	(	(	-LRB-
cord-018265-twp33bb6	446	68	iv	iv	LS
cord-018265-twp33bb6	446	69	)	)	-RRB-
cord-018265-twp33bb6	446	70	co	co	NN
cord-018265-twp33bb6	446	71	-	-	NN
cord-018265-twp33bb6	446	72	delivery	delivery	NN
cord-018265-twp33bb6	446	73	of	of	IN
cord-018265-twp33bb6	446	74	DNA	dna	NN
cord-018265-twp33bb6	446	75	constructs	construct	NNS
cord-018265-twp33bb6	446	76	coding	code	VBG
cord-018265-twp33bb6	446	77	for	for	IN
cord-018265-twp33bb6	446	78	immune	immune	JJ
cord-018265-twp33bb6	446	79	modulatory	modulatory	JJ
cord-018265-twp33bb6	446	80	molecules	molecule	NNS
cord-018265-twp33bb6	446	81	[	[	-LRB-
cord-018265-twp33bb6	446	82	189	189	CD
cord-018265-twp33bb6	446	83	]	]	-RRB-
cord-018265-twp33bb6	446	84	.	.	.
cord-018265-twp33bb6	447	1	In	in	IN
cord-018265-twp33bb6	447	2	addition	addition	NN
cord-018265-twp33bb6	447	3	,	,	,
cord-018265-twp33bb6	447	4	by	by	IN
cord-018265-twp33bb6	447	5	the	the	DT
cord-018265-twp33bb6	447	6	presence	presence	NN
cord-018265-twp33bb6	447	7	of	of	IN
cord-018265-twp33bb6	447	8	immune	immune	JJ
cord-018265-twp33bb6	447	9	stimulatory	stimulatory	JJ
cord-018265-twp33bb6	447	10	CpG	cpg	NN
cord-018265-twp33bb6	447	11	motifs	motif	NNS
cord-018265-twp33bb6	447	12	,	,	,
cord-018265-twp33bb6	447	13	the	the	DT
cord-018265-twp33bb6	447	14	DNA	dna	NN
cord-018265-twp33bb6	447	15	vaccine	vaccine	NN
cord-018265-twp33bb6	447	16	constructs	construct	NNS
cord-018265-twp33bb6	447	17	has	have	VBZ
cord-018265-twp33bb6	447	18	built	build	VBN
cord-018265-twp33bb6	447	19	-	-	HYPH
cord-018265-twp33bb6	447	20	in	in	RP
cord-018265-twp33bb6	447	21	adjuvant	adjuvant	NN
cord-018265-twp33bb6	447	22	properties	property	NNS
cord-018265-twp33bb6	447	23	.	.	.
cord-018265-twp33bb6	448	1	This	this	DT
cord-018265-twp33bb6	448	2	vaccination	vaccination	NN
cord-018265-twp33bb6	448	3	approach	approach	NN
cord-018265-twp33bb6	448	4	is	be	VBZ
cord-018265-twp33bb6	448	5	particularly	particularly	RB
cord-018265-twp33bb6	448	6	suited	suit	VBN
cord-018265-twp33bb6	448	7	for	for	IN
cord-018265-twp33bb6	448	8	the	the	DT
cord-018265-twp33bb6	448	9	stimulation	stimulation	NN
cord-018265-twp33bb6	448	10	of	of	IN
cord-018265-twp33bb6	448	11	cellular	cellular	JJ
cord-018265-twp33bb6	448	12	immune	immune	JJ
cord-018265-twp33bb6	448	13	responses	response	NNS
cord-018265-twp33bb6	448	14	[	[	-LRB-
cord-018265-twp33bb6	448	15	190	190	CD
cord-018265-twp33bb6	448	16	]	]	-RRB-
cord-018265-twp33bb6	448	17	.	.	.
cord-018265-twp33bb6	449	1	Interestingly	interestingly	RB
cord-018265-twp33bb6	449	2	,	,	,
cord-018265-twp33bb6	449	3	several	several	JJ
cord-018265-twp33bb6	449	4	reports	report	NNS
cord-018265-twp33bb6	449	5	suggest	suggest	VBP
cord-018265-twp33bb6	449	6	that	that	IN
cord-018265-twp33bb6	449	7	DNA	dna	NN
cord-018265-twp33bb6	449	8	vaccines	vaccine	NNS
cord-018265-twp33bb6	449	9	may	may	MD
cord-018265-twp33bb6	449	10	represent	represent	VB
cord-018265-twp33bb6	449	11	a	a	DT
cord-018265-twp33bb6	449	12	valid	valid	JJ
cord-018265-twp33bb6	449	13	alternative	alternative	NN
cord-018265-twp33bb6	449	14	to	to	IN
cord-018265-twp33bb6	449	15	prime	prime	JJ
cord-018265-twp33bb6	449	16	the	the	DT
cord-018265-twp33bb6	449	17	neonatal	neonatal	JJ
cord-018265-twp33bb6	449	18	immune	immune	JJ
cord-018265-twp33bb6	449	19	system	system	NN
cord-018265-twp33bb6	449	20	,	,	,
cord-018265-twp33bb6	449	21	even	even	RB
cord-018265-twp33bb6	449	22	in	in	IN
cord-018265-twp33bb6	449	23	the	the	DT
cord-018265-twp33bb6	449	24	presence	presence	NN
cord-018265-twp33bb6	449	25	of	of	IN
cord-018265-twp33bb6	449	26	passive	passive	JJ
cord-018265-twp33bb6	449	27	transferred	transfer	VBN
cord-018265-twp33bb6	449	28	maternal	maternal	JJ
cord-018265-twp33bb6	449	29	antibodies	antibody	NNS
cord-018265-twp33bb6	449	30	[	[	-LRB-
cord-018265-twp33bb6	449	31	191	191	CD
cord-018265-twp33bb6	449	32	,	,	,
cord-018265-twp33bb6	449	33	192	192	CD
cord-018265-twp33bb6	449	34	]	]	-RRB-
cord-018265-twp33bb6	449	35	.	.	.
cord-018265-twp33bb6	450	1	In	in	IN
cord-018265-twp33bb6	450	2	fact	fact	NN
cord-018265-twp33bb6	450	3	,	,	,
cord-018265-twp33bb6	450	4	promising	promising	JJ
cord-018265-twp33bb6	450	5	results	result	NNS
cord-018265-twp33bb6	450	6	were	be	VBD
cord-018265-twp33bb6	450	7	also	also	RB
cord-018265-twp33bb6	450	8	obtained	obtain	VBN
cord-018265-twp33bb6	450	9	in	in	IN
cord-018265-twp33bb6	450	10	preclinical	preclinical	JJ
cord-018265-twp33bb6	450	11	models	model	NNS
cord-018265-twp33bb6	450	12	of	of	IN
cord-018265-twp33bb6	450	13	community	community	NN
cord-018265-twp33bb6	450	14	-	-	HYPH
cord-018265-twp33bb6	450	15	acquired	acquire	VBN
cord-018265-twp33bb6	450	16	pneumonia	pneumonia	NN
cord-018265-twp33bb6	450	17	,	,	,
cord-018265-twp33bb6	450	18	such	such	JJ
cord-018265-twp33bb6	450	19	as	as	IN
cord-018265-twp33bb6	450	20	influenza	influenza	NN
cord-018265-twp33bb6	450	21	[	[	-LRB-
cord-018265-twp33bb6	450	22	193	193	CD
cord-018265-twp33bb6	450	23	]	]	-RRB-
cord-018265-twp33bb6	450	24	and	and	CC
cord-018265-twp33bb6	450	25	S.	S.	NNP
cord-018265-twp33bb6	450	26	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	450	27	[	[	-LRB-
cord-018265-twp33bb6	450	28	194	194	CD
cord-018265-twp33bb6	450	29	]	]	-RRB-
cord-018265-twp33bb6	450	30	.	.	.
cord-018265-twp33bb6	451	1	Furthermore	furthermore	RB
cord-018265-twp33bb6	451	2	,	,	,
cord-018265-twp33bb6	451	3	DNA	dna	NN
cord-018265-twp33bb6	451	4	coding	coding	NN
cord-018265-twp33bb6	451	5	for	for	IN
cord-018265-twp33bb6	451	6	vaccine	vaccine	NN
cord-018265-twp33bb6	451	7	antigens	antigen	NNS
cord-018265-twp33bb6	451	8	appears	appear	VBZ
cord-018265-twp33bb6	451	9	to	to	TO
cord-018265-twp33bb6	451	10	induce	induce	VB
cord-018265-twp33bb6	451	11	excellent	excellent	JJ
cord-018265-twp33bb6	451	12	immunological	immunological	JJ
cord-018265-twp33bb6	451	13	memory	memory	NN
cord-018265-twp33bb6	451	14	,	,	,
cord-018265-twp33bb6	451	15	which	which	WDT
cord-018265-twp33bb6	451	16	can	can	MD
cord-018265-twp33bb6	451	17	be	be	VB
cord-018265-twp33bb6	451	18	reawakened	reawaken	VBN
cord-018265-twp33bb6	451	19	by	by	IN
cord-018265-twp33bb6	451	20	later	later	JJ
cord-018265-twp33bb6	451	21	immunization	immunization	NN
cord-018265-twp33bb6	451	22	or	or	CC
cord-018265-twp33bb6	451	23	exposure	exposure	NN
cord-018265-twp33bb6	451	24	to	to	IN
cord-018265-twp33bb6	451	25	the	the	DT
cord-018265-twp33bb6	451	26	pathogen	pathogen	NN
cord-018265-twp33bb6	451	27	.	.	.
cord-018265-twp33bb6	452	1	The	the	DT
cord-018265-twp33bb6	452	2	knowledge	knowledge	NN
cord-018265-twp33bb6	452	3	generated	generate	VBN
cord-018265-twp33bb6	452	4	in	in	IN
cord-018265-twp33bb6	452	5	several	several	JJ
cord-018265-twp33bb6	452	6	basic	basic	JJ
cord-018265-twp33bb6	452	7	disciplines	discipline	NNS
cord-018265-twp33bb6	452	8	,	,	,
cord-018265-twp33bb6	452	9	such	such	JJ
cord-018265-twp33bb6	452	10	as	as	IN
cord-018265-twp33bb6	452	11	immunology	immunology	NN
cord-018265-twp33bb6	452	12	and	and	CC
cord-018265-twp33bb6	452	13	microbial	microbial	JJ
cord-018265-twp33bb6	452	14	pathogenesis	pathogenesis	NN
cord-018265-twp33bb6	452	15	,	,	,
cord-018265-twp33bb6	452	16	has	have	VBZ
cord-018265-twp33bb6	452	17	allowed	allow	VBN
cord-018265-twp33bb6	452	18	the	the	DT
cord-018265-twp33bb6	452	19	identification	identification	NN
cord-018265-twp33bb6	452	20	of	of	IN
cord-018265-twp33bb6	452	21	critical	critical	JJ
cord-018265-twp33bb6	452	22	bottlenecks	bottleneck	NNS
cord-018265-twp33bb6	452	23	for	for	IN
cord-018265-twp33bb6	452	24	establishing	establish	VBG
cord-018265-twp33bb6	452	25	a	a	DT
cord-018265-twp33bb6	452	26	successful	successful	JJ
cord-018265-twp33bb6	452	27	vaccination	vaccination	NN
cord-018265-twp33bb6	452	28	strategy	strategy	NN
cord-018265-twp33bb6	452	29	.	.	.
cord-018265-twp33bb6	453	1	It	-PRON-	PRP
cord-018265-twp33bb6	453	2	is	be	VBZ
cord-018265-twp33bb6	453	3	expected	expect	VBN
cord-018265-twp33bb6	453	4	that	that	IN
cord-018265-twp33bb6	453	5	in	in	IN
cord-018265-twp33bb6	453	6	the	the	DT
cord-018265-twp33bb6	453	7	coming	come	VBG
cord-018265-twp33bb6	453	8	years	year	NNS
cord-018265-twp33bb6	453	9	we	-PRON-	PRP
cord-018265-twp33bb6	453	10	will	will	MD
cord-018265-twp33bb6	453	11	develop	develop	VB
cord-018265-twp33bb6	453	12	customized	customize	VBN
cord-018265-twp33bb6	453	13	approaches	approach	NNS
cord-018265-twp33bb6	453	14	to	to	TO
cord-018265-twp33bb6	453	15	address	address	VB
cord-018265-twp33bb6	453	16	each	each	DT
cord-018265-twp33bb6	453	17	of	of	IN
cord-018265-twp33bb6	453	18	them	-PRON-	PRP
cord-018265-twp33bb6	453	19	,	,	,
cord-018265-twp33bb6	453	20	in	in	IN
cord-018265-twp33bb6	453	21	order	order	NN
cord-018265-twp33bb6	453	22	to	to	TO
cord-018265-twp33bb6	453	23	stimulate	stimulate	VB
cord-018265-twp33bb6	453	24	efficient	efficient	JJ
cord-018265-twp33bb6	453	25	protection	protection	NN
cord-018265-twp33bb6	453	26	against	against	IN
cord-018265-twp33bb6	453	27	infective	infective	JJ
cord-018265-twp33bb6	453	28	agents	agent	NNS
cord-018265-twp33bb6	453	29	under	under	IN
cord-018265-twp33bb6	453	30	specific	specific	JJ
cord-018265-twp33bb6	453	31	clinical	clinical	JJ
cord-018265-twp33bb6	453	32	settings	setting	NNS
cord-018265-twp33bb6	453	33	(	(	-LRB-
cord-018265-twp33bb6	453	34	i.e.	i.e.	FW
cord-018265-twp33bb6	453	35	,	,	,
cord-018265-twp33bb6	453	36	newborns	newborn	NNS
cord-018265-twp33bb6	453	37	,	,	,
cord-018265-twp33bb6	453	38	aging	age	VBG
cord-018265-twp33bb6	453	39	individuals	individual	NNS
cord-018265-twp33bb6	453	40	,	,	,
cord-018265-twp33bb6	453	41	immunocompromised	immunocompromised	JJ
cord-018265-twp33bb6	453	42	patients	patient	NNS
cord-018265-twp33bb6	453	43	)	)	-RRB-
cord-018265-twp33bb6	453	44	.	.	.
cord-018265-twp33bb6	454	1	The	the	DT
cord-018265-twp33bb6	454	2	importance	importance	NN
cord-018265-twp33bb6	454	3	of	of	IN
cord-018265-twp33bb6	454	4	immunological	immunological	JJ
cord-018265-twp33bb6	454	5	memory	memory	NN
cord-018265-twp33bb6	454	6	B	b	NN
cord-018265-twp33bb6	454	7	lymphocytes	lymphocyte	NNS
cord-018265-twp33bb6	454	8	that	that	WDT
cord-018265-twp33bb6	454	9	have	have	VBP
cord-018265-twp33bb6	454	10	differentiated	differentiate	VBN
cord-018265-twp33bb6	454	11	into	into	IN
cord-018265-twp33bb6	454	12	plasma	plasma	NN
cord-018265-twp33bb6	454	13	cells	cell	NNS
cord-018265-twp33bb6	454	14	are	be	VBP
cord-018265-twp33bb6	454	15	the	the	DT
cord-018265-twp33bb6	454	16	producers	producer	NNS
cord-018265-twp33bb6	454	17	of	of	IN
cord-018265-twp33bb6	454	18	antigen	antigen	NN
cord-018265-twp33bb6	454	19	-	-	HYPH
cord-018265-twp33bb6	454	20	specific	specific	JJ
cord-018265-twp33bb6	454	21	IgG	igg	NN
cord-018265-twp33bb6	454	22	antibodies	antibody	NNS
cord-018265-twp33bb6	454	23	.	.	.
cord-018265-twp33bb6	455	1	Bone	bone	NN
cord-018265-twp33bb6	455	2	-	-	HYPH
cord-018265-twp33bb6	455	3	marrow	marrow	NN
cord-018265-twp33bb6	455	4	(	(	-LRB-
cord-018265-twp33bb6	455	5	BM	BM	NNP
cord-018265-twp33bb6	455	6	)	)	-RRB-
cord-018265-twp33bb6	455	7	plasma	plasma	NN
cord-018265-twp33bb6	455	8	cells	cell	NNS
cord-018265-twp33bb6	455	9	have	have	VBP
cord-018265-twp33bb6	455	10	a	a	DT
cord-018265-twp33bb6	455	11	short	short	JJ
cord-018265-twp33bb6	455	12	life	life	NN
cord-018265-twp33bb6	455	13	,	,	,
cord-018265-twp33bb6	455	14	therefore	therefore	RB
cord-018265-twp33bb6	455	15	,	,	,
cord-018265-twp33bb6	455	16	the	the	DT
cord-018265-twp33bb6	455	17	BM	BM	NNP
cord-018265-twp33bb6	455	18	reservoir	reservoir	NN
cord-018265-twp33bb6	455	19	needs	need	VBZ
cord-018265-twp33bb6	455	20	to	to	TO
cord-018265-twp33bb6	455	21	be	be	VB
cord-018265-twp33bb6	455	22	replenished	replenish	VBN
cord-018265-twp33bb6	455	23	by	by	IN
cord-018265-twp33bb6	455	24	the	the	DT
cord-018265-twp33bb6	455	25	stimulation	stimulation	NN
cord-018265-twp33bb6	455	26	of	of	IN
cord-018265-twp33bb6	455	27	memory	memory	NN
cord-018265-twp33bb6	455	28	B	b	NN
cord-018265-twp33bb6	455	29	cells	cell	NNS
cord-018265-twp33bb6	455	30	[	[	-LRB-
cord-018265-twp33bb6	455	31	195	195	CD
cord-018265-twp33bb6	455	32	,	,	,
cord-018265-twp33bb6	455	33	196	196	CD
cord-018265-twp33bb6	455	34	]	]	-RRB-
cord-018265-twp33bb6	455	35	.	.	.
cord-018265-twp33bb6	456	1	The	the	DT
cord-018265-twp33bb6	456	2	maximal	maximal	JJ
cord-018265-twp33bb6	456	3	life	life	NN
cord-018265-twp33bb6	456	4	span	span	NN
cord-018265-twp33bb6	456	5	of	of	IN
cord-018265-twp33bb6	456	6	BM	BM	NNP
cord-018265-twp33bb6	456	7	plasma	plasma	NN
cord-018265-twp33bb6	456	8	cells	cell	NNS
cord-018265-twp33bb6	456	9	is	be	VBZ
cord-018265-twp33bb6	456	10	still	still	RB
cord-018265-twp33bb6	456	11	debated	debate	VBN
cord-018265-twp33bb6	456	12	.	.	.
cord-018265-twp33bb6	457	1	Only	only	RB
cord-018265-twp33bb6	457	2	few	few	JJ
cord-018265-twp33bb6	457	3	factors	factor	NNS
cord-018265-twp33bb6	457	4	have	have	VBP
cord-018265-twp33bb6	457	5	been	be	VBN
cord-018265-twp33bb6	457	6	identified	identify	VBN
cord-018265-twp33bb6	457	7	that	that	WDT
cord-018265-twp33bb6	457	8	control	control	VBP
cord-018265-twp33bb6	457	9	the	the	DT
cord-018265-twp33bb6	457	10	differentiation	differentiation	NN
cord-018265-twp33bb6	457	11	of	of	IN
cord-018265-twp33bb6	457	12	antigen	antigen	NN
cord-018265-twp33bb6	457	13	-	-	HYPH
cord-018265-twp33bb6	457	14	specific	specific	JJ
cord-018265-twp33bb6	457	15	B	b	NN
cord-018265-twp33bb6	457	16	cells	cell	NNS
cord-018265-twp33bb6	457	17	toward	toward	IN
cord-018265-twp33bb6	457	18	short	short	JJ
cord-018265-twp33bb6	457	19	-	-	HYPH
cord-018265-twp33bb6	457	20	or	or	CC
cord-018265-twp33bb6	457	21	long	long	JJ
cord-018265-twp33bb6	457	22	-	-	HYPH
cord-018265-twp33bb6	457	23	life	life	NN
cord-018265-twp33bb6	457	24	plasma	plasma	NN
cord-018265-twp33bb6	457	25	cells	cell	NNS
cord-018265-twp33bb6	457	26	or	or	CC
cord-018265-twp33bb6	457	27	to	to	IN
cord-018265-twp33bb6	457	28	memory	memory	NN
cord-018265-twp33bb6	457	29	B	b	NN
cord-018265-twp33bb6	457	30	cells	cell	NNS
cord-018265-twp33bb6	457	31	[	[	-LRB-
cord-018265-twp33bb6	457	32	119	119	CD
cord-018265-twp33bb6	457	33	]	]	-RRB-
cord-018265-twp33bb6	457	34	.	.	.
cord-018265-twp33bb6	458	1	Beside	beside	IN
cord-018265-twp33bb6	458	2	the	the	DT
cord-018265-twp33bb6	458	3	requirement	requirement	NN
cord-018265-twp33bb6	458	4	of	of	IN
cord-018265-twp33bb6	458	5	CD4	CD4	NNP
cord-018265-twp33bb6	458	6	+	+	CC
cord-018265-twp33bb6	458	7	T	T	NNP
cord-018265-twp33bb6	458	8	cells	cell	NNS
cord-018265-twp33bb6	458	9	,	,	,
cord-018265-twp33bb6	458	10	the	the	DT
cord-018265-twp33bb6	458	11	nature	nature	NN
cord-018265-twp33bb6	458	12	of	of	IN
cord-018265-twp33bb6	458	13	the	the	DT
cord-018265-twp33bb6	458	14	antigen	antigen	NN
cord-018265-twp33bb6	458	15	[	[	-LRB-
cord-018265-twp33bb6	458	16	197	197	CD
cord-018265-twp33bb6	458	17	]	]	-RRB-
cord-018265-twp33bb6	458	18	and	and	CC
cord-018265-twp33bb6	458	19	the	the	DT
cord-018265-twp33bb6	458	20	dose	dose	NN
cord-018265-twp33bb6	458	21	are	be	VBP
cord-018265-twp33bb6	458	22	also	also	RB
cord-018265-twp33bb6	458	23	important	important	JJ
cord-018265-twp33bb6	458	24	.	.	.
cord-018265-twp33bb6	459	1	Higher	high	JJR
cord-018265-twp33bb6	459	2	antigen	antigen	NN
cord-018265-twp33bb6	459	3	doses	dose	NNS
cord-018265-twp33bb6	459	4	,	,	,
cord-018265-twp33bb6	459	5	as	as	RB
cord-018265-twp33bb6	459	6	well	well	RB
cord-018265-twp33bb6	459	7	as	as	IN
cord-018265-twp33bb6	459	8	rapid	rapid	JJ
cord-018265-twp33bb6	459	9	vaccination	vaccination	NN
cord-018265-twp33bb6	459	10	schedules	schedule	NNS
cord-018265-twp33bb6	459	11	(	(	-LRB-
cord-018265-twp33bb6	459	12	closely	closely	RB
cord-018265-twp33bb6	459	13	spaced	spaced	JJ
cord-018265-twp33bb6	459	14	vaccine	vaccine	NN
cord-018265-twp33bb6	459	15	doses	dose	NNS
cord-018265-twp33bb6	459	16	)	)	-RRB-
cord-018265-twp33bb6	459	17	tend	tend	VBP
cord-018265-twp33bb6	459	18	to	to	TO
cord-018265-twp33bb6	459	19	favour	favour	VB
cord-018265-twp33bb6	459	20	the	the	DT
cord-018265-twp33bb6	459	21	rapid	rapid	JJ
cord-018265-twp33bb6	459	22	induction	induction	NN
cord-018265-twp33bb6	459	23	of	of	IN
cord-018265-twp33bb6	459	24	short	short	JJ
cord-018265-twp33bb6	459	25	-	-	HYPH
cord-018265-twp33bb6	459	26	term	term	NN
cord-018265-twp33bb6	459	27	effectors	effector	NNS
cord-018265-twp33bb6	459	28	,	,	,
cord-018265-twp33bb6	459	29	whereas	whereas	IN
cord-018265-twp33bb6	459	30	lower	low	JJR
cord-018265-twp33bb6	459	31	doses	dose	NNS
cord-018265-twp33bb6	459	32	of	of	IN
cord-018265-twp33bb6	459	33	antigens	antigen	NNS
cord-018265-twp33bb6	459	34	preferentially	preferentially	RB
cord-018265-twp33bb6	459	35	support	support	VBP
cord-018265-twp33bb6	459	36	the	the	DT
cord-018265-twp33bb6	459	37	induction	induction	NN
cord-018265-twp33bb6	459	38	of	of	IN
cord-018265-twp33bb6	459	39	immune	immune	JJ
cord-018265-twp33bb6	459	40	memory	memory	NN
cord-018265-twp33bb6	459	41	[	[	-LRB-
cord-018265-twp33bb6	459	42	198	198	CD
cord-018265-twp33bb6	459	43	]	]	-RRB-
cord-018265-twp33bb6	459	44	[	[	-LRB-
cord-018265-twp33bb6	459	45	199	199	CD
cord-018265-twp33bb6	459	46	]	]	-RRB-
cord-018265-twp33bb6	459	47	[	[	-LRB-
cord-018265-twp33bb6	459	48	200	200	CD
cord-018265-twp33bb6	459	49	]	]	-RRB-
cord-018265-twp33bb6	459	50	[	[	-LRB-
cord-018265-twp33bb6	459	51	201	201	CD
cord-018265-twp33bb6	459	52	]	]	-RRB-
cord-018265-twp33bb6	459	53	.	.	.
cord-018265-twp33bb6	460	1	It	-PRON-	PRP
cord-018265-twp33bb6	460	2	was	be	VBD
cord-018265-twp33bb6	460	3	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	460	4	that	that	IN
cord-018265-twp33bb6	460	5	neonatal	neonatal	JJ
cord-018265-twp33bb6	460	6	vaccination	vaccination	NN
cord-018265-twp33bb6	460	7	(	(	-LRB-
cord-018265-twp33bb6	460	8	priming	prime	VBG
cord-018265-twp33bb6	460	9	)	)	-RRB-
cord-018265-twp33bb6	460	10	and	and	CC
cord-018265-twp33bb6	460	11	infant	infant	NN
cord-018265-twp33bb6	460	12	boosting	boosting	NN
cord-018265-twp33bb6	460	13	might	may	MD
cord-018265-twp33bb6	460	14	be	be	VB
cord-018265-twp33bb6	460	15	effective	effective	JJ
cord-018265-twp33bb6	460	16	even	even	RB
cord-018265-twp33bb6	460	17	when	when	WRB
cord-018265-twp33bb6	460	18	pathogen	pathogen	NN
cord-018265-twp33bb6	460	19	exposure	exposure	NN
cord-018265-twp33bb6	460	20	occurs	occur	VBZ
cord-018265-twp33bb6	460	21	very	very	RB
cord-018265-twp33bb6	460	22	early	early	RB
cord-018265-twp33bb6	460	23	in	in	IN
cord-018265-twp33bb6	460	24	life	life	NN
cord-018265-twp33bb6	460	25	.	.	.
cord-018265-twp33bb6	461	1	In	in	IN
cord-018265-twp33bb6	461	2	children	child	NNS
cord-018265-twp33bb6	461	3	in	in	IN
cord-018265-twp33bb6	461	4	whom	whom	WP
cord-018265-twp33bb6	461	5	vaccine	vaccine	NN
cord-018265-twp33bb6	461	6	-	-	HYPH
cord-018265-twp33bb6	461	7	induced	induce	VBN
cord-018265-twp33bb6	461	8	Hib	Hib	NNP
cord-018265-twp33bb6	461	9	antibody	antibody	NN
cord-018265-twp33bb6	461	10	titres	titre	NNS
cord-018265-twp33bb6	461	11	have	have	VBP
cord-018265-twp33bb6	461	12	fallen	fall	VBN
cord-018265-twp33bb6	461	13	to	to	IN
cord-018265-twp33bb6	461	14	undetectable	undetectable	JJ
cord-018265-twp33bb6	461	15	levels	level	NNS
cord-018265-twp33bb6	461	16	,	,	,
cord-018265-twp33bb6	461	17	memory	memory	NN
cord-018265-twp33bb6	461	18	is	be	VBZ
cord-018265-twp33bb6	461	19	readily	readily	RB
cord-018265-twp33bb6	461	20	demonstrated	demonstrate	VBN
cord-018265-twp33bb6	461	21	[	[	-LRB-
cord-018265-twp33bb6	461	22	202	202	CD
cord-018265-twp33bb6	461	23	]	]	-RRB-
cord-018265-twp33bb6	461	24	.	.	.
cord-018265-twp33bb6	462	1	However	however	RB
cord-018265-twp33bb6	462	2	,	,	,
cord-018265-twp33bb6	462	3	immune	immune	JJ
cord-018265-twp33bb6	462	4	memory	memory	NN
cord-018265-twp33bb6	462	5	per	per	FW
cord-018265-twp33bb6	462	6	se	se	FW
cord-018265-twp33bb6	462	7	is	be	VBZ
cord-018265-twp33bb6	462	8	not	not	RB
cord-018265-twp33bb6	462	9	enough	enough	JJ
cord-018265-twp33bb6	462	10	to	to	TO
cord-018265-twp33bb6	462	11	protect	protect	VB
cord-018265-twp33bb6	462	12	against	against	IN
cord-018265-twp33bb6	462	13	pathogens	pathogen	NNS
cord-018265-twp33bb6	462	14	that	that	WDT
cord-018265-twp33bb6	462	15	required	require	VBD
cord-018265-twp33bb6	462	16	high	high	JJ
cord-018265-twp33bb6	462	17	levels	level	NNS
cord-018265-twp33bb6	462	18	of	of	IN
cord-018265-twp33bb6	462	19	neutralizing	neutralize	VBG
cord-018265-twp33bb6	462	20	antibodies	antibody	NNS
cord-018265-twp33bb6	462	21	.	.	.
cord-018265-twp33bb6	463	1	The	the	DT
cord-018265-twp33bb6	463	2	delay	delay	NN
cord-018265-twp33bb6	463	3	between	between	IN
cord-018265-twp33bb6	463	4	memory	memory	NN
cord-018265-twp33bb6	463	5	B	b	NN
cord-018265-twp33bb6	463	6	-	-	HYPH
cord-018265-twp33bb6	463	7	cell	cell	NN
cord-018265-twp33bb6	463	8	reactivation	reactivation	NN
cord-018265-twp33bb6	463	9	and	and	CC
cord-018265-twp33bb6	463	10	differentiation	differentiation	NN
cord-018265-twp33bb6	463	11	may	may	MD
cord-018265-twp33bb6	463	12	limit	limit	VB
cord-018265-twp33bb6	463	13	the	the	DT
cord-018265-twp33bb6	463	14	ability	ability	NN
cord-018265-twp33bb6	463	15	to	to	TO
cord-018265-twp33bb6	463	16	interrupt	interrupt	VB
cord-018265-twp33bb6	463	17	pathogen	pathogen	NN
cord-018265-twp33bb6	463	18	invasion	invasion	NN
cord-018265-twp33bb6	463	19	.	.	.
cord-018265-twp33bb6	464	1	Therefore	therefore	RB
cord-018265-twp33bb6	464	2	,	,	,
cord-018265-twp33bb6	464	3	it	-PRON-	PRP
cord-018265-twp33bb6	464	4	is	be	VBZ
cord-018265-twp33bb6	464	5	important	important	JJ
cord-018265-twp33bb6	464	6	to	to	TO
cord-018265-twp33bb6	464	7	establish	establish	VB
cord-018265-twp33bb6	464	8	vaccination	vaccination	NN
cord-018265-twp33bb6	464	9	protocols	protocol	NNS
cord-018265-twp33bb6	464	10	in	in	IN
cord-018265-twp33bb6	464	11	which	which	WDT
cord-018265-twp33bb6	464	12	the	the	DT
cord-018265-twp33bb6	464	13	population	population	NN
cord-018265-twp33bb6	464	14	is	be	VBZ
cord-018265-twp33bb6	464	15	boosted	boost	VBN
cord-018265-twp33bb6	464	16	at	at	IN
cord-018265-twp33bb6	464	17	different	different	JJ
cord-018265-twp33bb6	464	18	ages	age	NNS
cord-018265-twp33bb6	464	19	in	in	IN
cord-018265-twp33bb6	464	20	order	order	NN
cord-018265-twp33bb6	464	21	to	to	TO
cord-018265-twp33bb6	464	22	maintain	maintain	VB
cord-018265-twp33bb6	464	23	the	the	DT
cord-018265-twp33bb6	464	24	required	require	VBN
cord-018265-twp33bb6	464	25	levels	level	NNS
cord-018265-twp33bb6	464	26	of	of	IN
cord-018265-twp33bb6	464	27	antibodies	antibody	NNS
cord-018265-twp33bb6	464	28	.	.	.
cord-018265-twp33bb6	465	1	This	this	DT
cord-018265-twp33bb6	465	2	is	be	VBZ
cord-018265-twp33bb6	465	3	particularly	particularly	RB
cord-018265-twp33bb6	465	4	important	important	JJ
cord-018265-twp33bb6	465	5	in	in	IN
cord-018265-twp33bb6	465	6	diseases	disease	NNS
cord-018265-twp33bb6	465	7	in	in	IN
cord-018265-twp33bb6	465	8	which	which	WDT
cord-018265-twp33bb6	465	9	antibodies	antibody	NNS
cord-018265-twp33bb6	465	10	play	play	VBP
cord-018265-twp33bb6	465	11	a	a	DT
cord-018265-twp33bb6	465	12	central	central	JJ
cord-018265-twp33bb6	465	13	role	role	NN
cord-018265-twp33bb6	465	14	in	in	IN
cord-018265-twp33bb6	465	15	microbial	microbial	JJ
cord-018265-twp33bb6	465	16	clearance	clearance	NN
cord-018265-twp33bb6	465	17	or	or	CC
cord-018265-twp33bb6	465	18	toxin	toxin	NN
cord-018265-twp33bb6	465	19	neutralization	neutralization	NN
cord-018265-twp33bb6	465	20	.	.	.
cord-018265-twp33bb6	466	1	In	in	IN
cord-018265-twp33bb6	466	2	the	the	DT
cord-018265-twp33bb6	466	3	particular	particular	JJ
cord-018265-twp33bb6	466	4	case	case	NN
cord-018265-twp33bb6	466	5	of	of	IN
cord-018265-twp33bb6	466	6	community	community	NN
cord-018265-twp33bb6	466	7	-	-	HYPH
cord-018265-twp33bb6	466	8	acquired	acquire	VBN
cord-018265-twp33bb6	466	9	pneumonia	pneumonia	NN
cord-018265-twp33bb6	466	10	,	,	,
cord-018265-twp33bb6	466	11	we	-PRON-	PRP
cord-018265-twp33bb6	466	12	should	should	MD
cord-018265-twp33bb6	466	13	consider	consider	VB
cord-018265-twp33bb6	466	14	that	that	IN
cord-018265-twp33bb6	466	15	aging	age	VBG
cord-018265-twp33bb6	466	16	individuals	individual	NNS
cord-018265-twp33bb6	466	17	are	be	VBP
cord-018265-twp33bb6	466	18	neglected	neglect	VBN
cord-018265-twp33bb6	466	19	in	in	IN
cord-018265-twp33bb6	466	20	many	many	JJ
cord-018265-twp33bb6	466	21	vaccination	vaccination	NN
cord-018265-twp33bb6	466	22	programs	program	NNS
cord-018265-twp33bb6	466	23	.	.	.
cord-018265-twp33bb6	467	1	However	however	RB
cord-018265-twp33bb6	467	2	,	,	,
cord-018265-twp33bb6	467	3	the	the	DT
cord-018265-twp33bb6	467	4	strategies	strategy	NNS
cord-018265-twp33bb6	467	5	proposed	propose	VBN
cord-018265-twp33bb6	467	6	for	for	IN
cord-018265-twp33bb6	467	7	elderly	elderly	JJ
cord-018265-twp33bb6	467	8	would	would	MD
cord-018265-twp33bb6	467	9	be	be	VB
cord-018265-twp33bb6	467	10	different	different	JJ
cord-018265-twp33bb6	467	11	from	from	IN
cord-018265-twp33bb6	467	12	those	those	DT
cord-018265-twp33bb6	467	13	used	use	VBN
cord-018265-twp33bb6	467	14	for	for	IN
cord-018265-twp33bb6	467	15	small	small	JJ
cord-018265-twp33bb6	467	16	children	child	NNS
cord-018265-twp33bb6	467	17	,	,	,
cord-018265-twp33bb6	467	18	since	since	IN
cord-018265-twp33bb6	467	19	the	the	DT
cord-018265-twp33bb6	467	20	main	main	JJ
cord-018265-twp33bb6	467	21	factors	factor	NNS
cord-018265-twp33bb6	467	22	affecting	affect	VBG
cord-018265-twp33bb6	467	23	vaccine	vaccine	NN
cord-018265-twp33bb6	467	24	efficacy	efficacy	NN
cord-018265-twp33bb6	467	25	are	be	VBP
cord-018265-twp33bb6	467	26	immune	immune	JJ
cord-018265-twp33bb6	467	27	senescence	senescence	NN
cord-018265-twp33bb6	467	28	and	and	CC
cord-018265-twp33bb6	467	29	immaturity	immaturity	NN
cord-018265-twp33bb6	467	30	,	,	,
cord-018265-twp33bb6	467	31	respectively	respectively	RB
cord-018265-twp33bb6	467	32	.	.	.
cord-018265-twp33bb6	468	1	The	the	DT
cord-018265-twp33bb6	468	2	attempts	attempt	NNS
cord-018265-twp33bb6	468	3	to	to	TO
cord-018265-twp33bb6	468	4	give	give	VB
cord-018265-twp33bb6	468	5	a	a	DT
cord-018265-twp33bb6	468	6	rational	rational	JJ
cord-018265-twp33bb6	468	7	solution	solution	NN
cord-018265-twp33bb6	468	8	to	to	IN
cord-018265-twp33bb6	468	9	this	this	DT
cord-018265-twp33bb6	468	10	issue	issue	NN
cord-018265-twp33bb6	468	11	are	be	VBP
cord-018265-twp33bb6	468	12	discussed	discuss	VBN
cord-018265-twp33bb6	468	13	in	in	IN
cord-018265-twp33bb6	468	14	the	the	DT
cord-018265-twp33bb6	468	15	next	next	JJ
cord-018265-twp33bb6	468	16	sections	section	NNS
cord-018265-twp33bb6	468	17	.	.	.
cord-018265-twp33bb6	469	1	The	the	DT
cord-018265-twp33bb6	469	2	immune	immune	JJ
cord-018265-twp33bb6	469	3	system	system	NN
cord-018265-twp33bb6	469	4	in	in	IN
cord-018265-twp33bb6	469	5	children	child	NNS
cord-018265-twp33bb6	469	6	Immune	immune	VBP
cord-018265-twp33bb6	469	7	responses	response	NNS
cord-018265-twp33bb6	469	8	to	to	IN
cord-018265-twp33bb6	469	9	bacterial	bacterial	JJ
cord-018265-twp33bb6	469	10	and	and	CC
cord-018265-twp33bb6	469	11	viral	viral	JJ
cord-018265-twp33bb6	469	12	antigens	antigen	NNS
cord-018265-twp33bb6	469	13	usually	usually	RB
cord-018265-twp33bb6	469	14	increase	increase	VBP
cord-018265-twp33bb6	469	15	with	with	IN
cord-018265-twp33bb6	469	16	age	age	NN
cord-018265-twp33bb6	469	17	in	in	IN
cord-018265-twp33bb6	469	18	a	a	DT
cord-018265-twp33bb6	469	19	stepwise	stepwise	JJ
cord-018265-twp33bb6	469	20	manner	manner	NN
cord-018265-twp33bb6	469	21	[	[	-LRB-
cord-018265-twp33bb6	469	22	203	203	CD
cord-018265-twp33bb6	469	23	]	]	-RRB-
cord-018265-twp33bb6	469	24	.	.	.
cord-018265-twp33bb6	470	1	Prompt	prompt	JJ
cord-018265-twp33bb6	470	2	immunization	immunization	NN
cord-018265-twp33bb6	470	3	after	after	IN
cord-018265-twp33bb6	470	4	birth	birth	NN
cord-018265-twp33bb6	470	5	is	be	VBZ
cord-018265-twp33bb6	470	6	required	require	VBN
cord-018265-twp33bb6	470	7	to	to	TO
cord-018265-twp33bb6	470	8	induce	induce	VB
cord-018265-twp33bb6	470	9	active	active	JJ
cord-018265-twp33bb6	470	10	immunity	immunity	NN
cord-018265-twp33bb6	470	11	against	against	IN
cord-018265-twp33bb6	470	12	diseases	disease	NNS
cord-018265-twp33bb6	470	13	that	that	WDT
cord-018265-twp33bb6	470	14	may	may	MD
cord-018265-twp33bb6	470	15	occur	occur	VB
cord-018265-twp33bb6	470	16	early	early	RB
cord-018265-twp33bb6	470	17	in	in	IN
cord-018265-twp33bb6	470	18	life	life	NN
cord-018265-twp33bb6	470	19	.	.	.
cord-018265-twp33bb6	471	1	Unfortunately	unfortunately	RB
cord-018265-twp33bb6	471	2	,	,	,
cord-018265-twp33bb6	471	3	this	this	DT
cord-018265-twp33bb6	471	4	strategy	strategy	NN
cord-018265-twp33bb6	471	5	is	be	VBZ
cord-018265-twp33bb6	471	6	limited	limit	VBN
cord-018265-twp33bb6	471	7	by	by	IN
cord-018265-twp33bb6	471	8	the	the	DT
cord-018265-twp33bb6	471	9	relative	relative	JJ
cord-018265-twp33bb6	471	10	immaturity	immaturity	NN
cord-018265-twp33bb6	471	11	of	of	IN
cord-018265-twp33bb6	471	12	the	the	DT
cord-018265-twp33bb6	471	13	neonatal	neonatal	JJ
cord-018265-twp33bb6	471	14	and	and	CC
cord-018265-twp33bb6	471	15	infant	infant	NN
cord-018265-twp33bb6	471	16	immune	immune	NN
cord-018265-twp33bb6	471	17	system	system	NN
cord-018265-twp33bb6	471	18	.	.	.
cord-018265-twp33bb6	472	1	Some	some	DT
cord-018265-twp33bb6	472	2	factors	factor	NNS
cord-018265-twp33bb6	472	3	implicated	implicate	VBN
cord-018265-twp33bb6	472	4	in	in	IN
cord-018265-twp33bb6	472	5	this	this	DT
cord-018265-twp33bb6	472	6	poor	poor	JJ
cord-018265-twp33bb6	472	7	response	response	NN
cord-018265-twp33bb6	472	8	are	be	VBP
cord-018265-twp33bb6	472	9	the	the	DT
cord-018265-twp33bb6	472	10	limited	limited	JJ
cord-018265-twp33bb6	472	11	switch	switch	NN
cord-018265-twp33bb6	472	12	from	from	IN
cord-018265-twp33bb6	472	13	IgM	IgM	NNP
cord-018265-twp33bb6	472	14	to	to	IN
cord-018265-twp33bb6	472	15	IgG2	IgG2	NNP
cord-018265-twp33bb6	472	16	antibodies	antibody	NNS
cord-018265-twp33bb6	472	17	,	,	,
cord-018265-twp33bb6	472	18	impaired	impair	VBN
cord-018265-twp33bb6	472	19	complement	complement	NN
cord-018265-twp33bb6	472	20	-	-	HYPH
cord-018265-twp33bb6	472	21	mediated	mediate	VBN
cord-018265-twp33bb6	472	22	reactions	reaction	NNS
cord-018265-twp33bb6	472	23	and	and	CC
cord-018265-twp33bb6	472	24	deficient	deficient	JJ
cord-018265-twp33bb6	472	25	organization	organization	NN
cord-018265-twp33bb6	472	26	of	of	IN
cord-018265-twp33bb6	472	27	the	the	DT
cord-018265-twp33bb6	472	28	splenic	splenic	NNP
cord-018265-twp33bb6	472	29	marginal	marginal	JJ
cord-018265-twp33bb6	472	30	zone	zone	NN
cord-018265-twp33bb6	472	31	.	.	.
cord-018265-twp33bb6	473	1	Vaccination	vaccination	NN
cord-018265-twp33bb6	473	2	studies	study	NNS
cord-018265-twp33bb6	473	3	performed	perform	VBN
cord-018265-twp33bb6	473	4	in	in	IN
cord-018265-twp33bb6	473	5	newborn	newborn	JJ
cord-018265-twp33bb6	473	6	mice	mouse	NNS
cord-018265-twp33bb6	473	7	suggested	suggest	VBD
cord-018265-twp33bb6	473	8	that	that	IN
cord-018265-twp33bb6	473	9	limited	limit	VBN
cord-018265-twp33bb6	473	10	germinal	germinal	JJ
cord-018265-twp33bb6	473	11	centre	centre	NN
cord-018265-twp33bb6	473	12	reactions	reaction	NNS
cord-018265-twp33bb6	473	13	may	may	MD
cord-018265-twp33bb6	473	14	results	results	VB
cord-018265-twp33bb6	473	15	from	from	IN
cord-018265-twp33bb6	473	16	the	the	DT
cord-018265-twp33bb6	473	17	delayed	delay	VBN
cord-018265-twp33bb6	473	18	devel	devel	NN
cord-018265-twp33bb6	473	19	-	-	HYPH
cord-018265-twp33bb6	473	20	opment	opment	NN
cord-018265-twp33bb6	473	21	of	of	IN
cord-018265-twp33bb6	473	22	follicular	follicular	JJ
cord-018265-twp33bb6	473	23	DC	DC	NNP
cord-018265-twp33bb6	473	24	and	and	CC
cord-018265-twp33bb6	473	25	limit	limit	VB
cord-018265-twp33bb6	473	26	plasma	plasma	NN
cord-018265-twp33bb6	473	27	cell	cell	NN
cord-018265-twp33bb6	473	28	differentiation	differentiation	NN
cord-018265-twp33bb6	473	29	[	[	-LRB-
cord-018265-twp33bb6	473	30	204	204	CD
cord-018265-twp33bb6	473	31	]	]	-RRB-
cord-018265-twp33bb6	473	32	.	.	.
cord-018265-twp33bb6	474	1	It	-PRON-	PRP
cord-018265-twp33bb6	474	2	was	be	VBD
cord-018265-twp33bb6	474	3	also	also	RB
cord-018265-twp33bb6	474	4	showed	show	VBN
cord-018265-twp33bb6	474	5	that	that	IN
cord-018265-twp33bb6	474	6	the	the	DT
cord-018265-twp33bb6	474	7	neonatal	neonatal	JJ
cord-018265-twp33bb6	474	8	BM	BM	NNP
cord-018265-twp33bb6	474	9	has	have	VBZ
cord-018265-twp33bb6	474	10	a	a	DT
cord-018265-twp33bb6	474	11	limited	limited	JJ
cord-018265-twp33bb6	474	12	capacity	capacity	NN
cord-018265-twp33bb6	474	13	to	to	TO
cord-018265-twp33bb6	474	14	support	support	VB
cord-018265-twp33bb6	474	15	the	the	DT
cord-018265-twp33bb6	474	16	establishment	establishment	NN
cord-018265-twp33bb6	474	17	of	of	IN
cord-018265-twp33bb6	474	18	long	long	JJ
cord-018265-twp33bb6	474	19	-	-	HYPH
cord-018265-twp33bb6	474	20	life	life	NN
cord-018265-twp33bb6	474	21	antibody	antibody	NN
cord-018265-twp33bb6	474	22	-	-	HYPH
cord-018265-twp33bb6	474	23	secreting	secrete	VBG
cord-018265-twp33bb6	474	24	plasma	plasma	NN
cord-018265-twp33bb6	474	25	cells	cell	NNS
cord-018265-twp33bb6	474	26	[	[	-LRB-
cord-018265-twp33bb6	474	27	205	205	CD
cord-018265-twp33bb6	474	28	]	]	-RRB-
cord-018265-twp33bb6	474	29	.	.	.
cord-018265-twp33bb6	475	1	Thus	thus	RB
cord-018265-twp33bb6	475	2	,	,	,
cord-018265-twp33bb6	475	3	the	the	DT
cord-018265-twp33bb6	475	4	responses	response	NNS
cord-018265-twp33bb6	475	5	to	to	IN
cord-018265-twp33bb6	475	6	glyco	glyco	NNP
cord-018265-twp33bb6	475	7	-	-	HYPH
cord-018265-twp33bb6	475	8	conjugates	conjugate	NNS
cord-018265-twp33bb6	475	9	and	and	CC
cord-018265-twp33bb6	475	10	to	to	IN
cord-018265-twp33bb6	475	11	most	most	JJS
cord-018265-twp33bb6	475	12	T	t	NN
cord-018265-twp33bb6	475	13	-	-	HYPH
cord-018265-twp33bb6	475	14	cell	cell	NN
cord-018265-twp33bb6	475	15	-	-	HYPH
cord-018265-twp33bb6	475	16	dependent	dependent	JJ
cord-018265-twp33bb6	475	17	antigens	antigen	NNS
cord-018265-twp33bb6	475	18	are	be	VBP
cord-018265-twp33bb6	475	19	usually	usually	RB
cord-018265-twp33bb6	475	20	affected	affect	VBN
cord-018265-twp33bb6	475	21	[	[	-LRB-
cord-018265-twp33bb6	475	22	119	119	CD
cord-018265-twp33bb6	475	23	]	]	-RRB-
cord-018265-twp33bb6	475	24	.	.	.
cord-018265-twp33bb6	476	1	Therefore	therefore	RB
cord-018265-twp33bb6	476	2	,	,	,
cord-018265-twp33bb6	476	3	only	only	RB
cord-018265-twp33bb6	476	4	few	few	JJ
cord-018265-twp33bb6	476	5	and	and	CC
cord-018265-twp33bb6	476	6	highly	highly	RB
cord-018265-twp33bb6	476	7	immunogenic	immunogenic	JJ
cord-018265-twp33bb6	476	8	vaccines	vaccine	NNS
cord-018265-twp33bb6	476	9	show	show	VBP
cord-018265-twp33bb6	476	10	significant	significant	JJ
cord-018265-twp33bb6	476	11	protective	protective	JJ
cord-018265-twp33bb6	476	12	efficacy	efficacy	NN
cord-018265-twp33bb6	476	13	after	after	IN
cord-018265-twp33bb6	476	14	a	a	DT
cord-018265-twp33bb6	476	15	single	single	JJ
cord-018265-twp33bb6	476	16	dose	dose	NN
cord-018265-twp33bb6	476	17	in	in	IN
cord-018265-twp33bb6	476	18	infants	infant	NNS
cord-018265-twp33bb6	476	19	.	.	.
cord-018265-twp33bb6	477	1	The	the	DT
cord-018265-twp33bb6	477	2	limited	limited	JJ
cord-018265-twp33bb6	477	3	IgG	igg	NN
cord-018265-twp33bb6	477	4	responses	response	NNS
cord-018265-twp33bb6	477	5	are	be	VBP
cord-018265-twp33bb6	477	6	extended	extend	VBN
cord-018265-twp33bb6	477	7	all	all	RB
cord-018265-twp33bb6	477	8	over	over	IN
cord-018265-twp33bb6	477	9	the	the	DT
cord-018265-twp33bb6	477	10	first	first	JJ
cord-018265-twp33bb6	477	11	year	year	NN
cord-018265-twp33bb6	477	12	of	of	IN
cord-018265-twp33bb6	477	13	life	life	NN
cord-018265-twp33bb6	477	14	.	.	.
cord-018265-twp33bb6	478	1	In	in	IN
cord-018265-twp33bb6	478	2	addition	addition	NN
cord-018265-twp33bb6	478	3	,	,	,
cord-018265-twp33bb6	478	4	the	the	DT
cord-018265-twp33bb6	478	5	immune	immune	JJ
cord-018265-twp33bb6	478	6	responses	response	NNS
cord-018265-twp33bb6	478	7	,	,	,
cord-018265-twp33bb6	478	8	particularly	particularly	RB
cord-018265-twp33bb6	478	9	antibodies	antibody	NNS
cord-018265-twp33bb6	478	10	,	,	,
cord-018265-twp33bb6	478	11	elicited	elicit	VBN
cord-018265-twp33bb6	478	12	in	in	IN
cord-018265-twp33bb6	478	13	the	the	DT
cord-018265-twp33bb6	478	14	first	first	JJ
cord-018265-twp33bb6	478	15	year	year	NN
cord-018265-twp33bb6	478	16	of	of	IN
cord-018265-twp33bb6	478	17	life	life	NN
cord-018265-twp33bb6	478	18	after	after	IN
cord-018265-twp33bb6	478	19	vaccination	vaccination	NN
cord-018265-twp33bb6	478	20	rapidly	rapidly	RB
cord-018265-twp33bb6	478	21	decline	decline	VBP
cord-018265-twp33bb6	478	22	[	[	-LRB-
cord-018265-twp33bb6	478	23	203	203	CD
cord-018265-twp33bb6	478	24	]	]	-RRB-
cord-018265-twp33bb6	478	25	.	.	.
cord-018265-twp33bb6	479	1	However	however	RB
cord-018265-twp33bb6	479	2	,	,	,
cord-018265-twp33bb6	479	3	the	the	DT
cord-018265-twp33bb6	479	4	problem	problem	NN
cord-018265-twp33bb6	479	5	observed	observe	VBD
cord-018265-twp33bb6	479	6	in	in	IN
cord-018265-twp33bb6	479	7	infants	infant	NNS
cord-018265-twp33bb6	479	8	in	in	IN
cord-018265-twp33bb6	479	9	terms	term	NNS
cord-018265-twp33bb6	479	10	of	of	IN
cord-018265-twp33bb6	479	11	magnitude	magnitude	NN
cord-018265-twp33bb6	479	12	and	and	CC
cord-018265-twp33bb6	479	13	duration	duration	NN
cord-018265-twp33bb6	479	14	of	of	IN
cord-018265-twp33bb6	479	15	immune	immune	JJ
cord-018265-twp33bb6	479	16	response	response	NN
cord-018265-twp33bb6	479	17	does	do	VBZ
cord-018265-twp33bb6	479	18	not	not	RB
cord-018265-twp33bb6	479	19	seem	seem	VB
cord-018265-twp33bb6	479	20	to	to	TO
cord-018265-twp33bb6	479	21	affect	affect	VB
cord-018265-twp33bb6	479	22	efficient	efficient	JJ
cord-018265-twp33bb6	479	23	priming	priming	NN
cord-018265-twp33bb6	479	24	.	.	.
cord-018265-twp33bb6	480	1	In	in	IN
cord-018265-twp33bb6	480	2	fact	fact	NN
cord-018265-twp33bb6	480	3	,	,	,
cord-018265-twp33bb6	480	4	the	the	DT
cord-018265-twp33bb6	480	5	immune	immune	JJ
cord-018265-twp33bb6	480	6	memory	memory	NN
cord-018265-twp33bb6	480	7	generated	generate	VBN
cord-018265-twp33bb6	480	8	in	in	IN
cord-018265-twp33bb6	480	9	neonates	neonate	NNS
cord-018265-twp33bb6	480	10	may	may	MD
cord-018265-twp33bb6	480	11	be	be	VB
cord-018265-twp33bb6	480	12	recalled	recall	VBN
cord-018265-twp33bb6	480	13	later	later	RB
cord-018265-twp33bb6	480	14	in	in	IN
cord-018265-twp33bb6	480	15	life	life	NN
cord-018265-twp33bb6	480	16	[	[	-LRB-
cord-018265-twp33bb6	480	17	119	119	CD
cord-018265-twp33bb6	480	18	]	]	-RRB-
cord-018265-twp33bb6	480	19	.	.	.
cord-018265-twp33bb6	481	1	Nevertheless	nevertheless	RB
cord-018265-twp33bb6	481	2	,	,	,
cord-018265-twp33bb6	481	3	strategies	strategy	NNS
cord-018265-twp33bb6	481	4	to	to	TO
cord-018265-twp33bb6	481	5	generate	generate	VB
cord-018265-twp33bb6	481	6	strong	strong	JJ
cord-018265-twp33bb6	481	7	and	and	CC
cord-018265-twp33bb6	481	8	long	long	RB
cord-018265-twp33bb6	481	9	-	-	HYPH
cord-018265-twp33bb6	481	10	lasting	last	VBG
cord-018265-twp33bb6	481	11	protective	protective	JJ
cord-018265-twp33bb6	481	12	responses	response	NNS
cord-018265-twp33bb6	481	13	in	in	IN
cord-018265-twp33bb6	481	14	infants	infant	NNS
cord-018265-twp33bb6	481	15	are	be	VBP
cord-018265-twp33bb6	481	16	still	still	RB
cord-018265-twp33bb6	481	17	needed	need	VBN
cord-018265-twp33bb6	481	18	.	.	.
cord-018265-twp33bb6	482	1	This	this	DT
cord-018265-twp33bb6	482	2	is	be	VBZ
cord-018265-twp33bb6	482	3	in	in	IN
cord-018265-twp33bb6	482	4	part	part	NN
cord-018265-twp33bb6	482	5	due	due	IN
cord-018265-twp33bb6	482	6	to	to	IN
cord-018265-twp33bb6	482	7	the	the	DT
cord-018265-twp33bb6	482	8	presence	presence	NN
cord-018265-twp33bb6	482	9	of	of	IN
cord-018265-twp33bb6	482	10	maternal	maternal	JJ
cord-018265-twp33bb6	482	11	antibodies	antibody	NNS
cord-018265-twp33bb6	482	12	,	,	,
cord-018265-twp33bb6	482	13	which	which	WDT
cord-018265-twp33bb6	482	14	inactivate	inactivate	VBP
cord-018265-twp33bb6	482	15	and	and	CC
cord-018265-twp33bb6	482	16	clear	clear	VB
cord-018265-twp33bb6	482	17	the	the	DT
cord-018265-twp33bb6	482	18	vaccine	vaccine	NN
cord-018265-twp33bb6	482	19	antigens	antigen	NNS
cord-018265-twp33bb6	482	20	,	,	,
cord-018265-twp33bb6	482	21	thereby	thereby	RB
cord-018265-twp33bb6	482	22	rendering	render	VBG
cord-018265-twp33bb6	482	23	difficult	difficult	JJ
cord-018265-twp33bb6	482	24	the	the	DT
cord-018265-twp33bb6	482	25	stimulation	stimulation	NN
cord-018265-twp33bb6	482	26	of	of	IN
cord-018265-twp33bb6	482	27	an	an	DT
cord-018265-twp33bb6	482	28	immature	immature	JJ
cord-018265-twp33bb6	482	29	immune	immune	JJ
cord-018265-twp33bb6	482	30	system	system	NN
cord-018265-twp33bb6	482	31	[	[	-LRB-
cord-018265-twp33bb6	482	32	203	203	CD
cord-018265-twp33bb6	482	33	]	]	-RRB-
cord-018265-twp33bb6	482	34	.	.	.
cord-018265-twp33bb6	483	1	In	in	IN
cord-018265-twp33bb6	483	2	addition	addition	NN
cord-018265-twp33bb6	483	3	,	,	,
cord-018265-twp33bb6	483	4	the	the	DT
cord-018265-twp33bb6	483	5	effects	effect	NNS
cord-018265-twp33bb6	483	6	of	of	IN
cord-018265-twp33bb6	483	7	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	483	8	reported	report	VBN
cord-018265-twp33bb6	483	9	in	in	IN
cord-018265-twp33bb6	483	10	adults	adult	NNS
cord-018265-twp33bb6	483	11	can	can	MD
cord-018265-twp33bb6	483	12	not	not	RB
cord-018265-twp33bb6	483	13	be	be	VB
cord-018265-twp33bb6	483	14	extrapolated	extrapolate	VBN
cord-018265-twp33bb6	483	15	to	to	IN
cord-018265-twp33bb6	483	16	neonates	neonate	NNS
cord-018265-twp33bb6	483	17	[	[	-LRB-
cord-018265-twp33bb6	483	18	206	206	CD
cord-018265-twp33bb6	483	19	]	]	-RRB-
cord-018265-twp33bb6	483	20	.	.	.
cord-018265-twp33bb6	484	1	A	a	DT
cord-018265-twp33bb6	484	2	potential	potential	JJ
cord-018265-twp33bb6	484	3	strategy	strategy	NN
cord-018265-twp33bb6	484	4	to	to	TO
cord-018265-twp33bb6	484	5	overcome	overcome	VB
cord-018265-twp33bb6	484	6	these	these	DT
cord-018265-twp33bb6	484	7	problems	problem	NNS
cord-018265-twp33bb6	484	8	would	would	MD
cord-018265-twp33bb6	484	9	be	be	VB
cord-018265-twp33bb6	484	10	to	to	TO
cord-018265-twp33bb6	484	11	implement	implement	VB
cord-018265-twp33bb6	484	12	vaccination	vaccination	NN
cord-018265-twp33bb6	484	13	during	during	IN
cord-018265-twp33bb6	484	14	pregnancy	pregnancy	NN
cord-018265-twp33bb6	484	15	,	,	,
cord-018265-twp33bb6	484	16	to	to	TO
cord-018265-twp33bb6	484	17	provide	provide	VB
cord-018265-twp33bb6	484	18	the	the	DT
cord-018265-twp33bb6	484	19	required	require	VBN
cord-018265-twp33bb6	484	20	antibodies	antibody	NNS
cord-018265-twp33bb6	484	21	by	by	IN
cord-018265-twp33bb6	484	22	placenta	placenta	NN
cord-018265-twp33bb6	484	23	and	and	CC
cord-018265-twp33bb6	484	24	later	later	RB
cord-018265-twp33bb6	484	25	by	by	IN
cord-018265-twp33bb6	484	26	maternal	maternal	JJ
cord-018265-twp33bb6	484	27	feeding	feeding	NN
cord-018265-twp33bb6	484	28	[	[	-LRB-
cord-018265-twp33bb6	484	29	30	30	CD
cord-018265-twp33bb6	484	30	,	,	,
cord-018265-twp33bb6	484	31	[	[	-LRB-
cord-018265-twp33bb6	484	32	207	207	CD
cord-018265-twp33bb6	484	33	]	]	-RRB-
cord-018265-twp33bb6	484	34	[	[	-LRB-
cord-018265-twp33bb6	484	35	208	208	CD
cord-018265-twp33bb6	484	36	]	]	-RRB-
cord-018265-twp33bb6	484	37	[	[	-LRB-
cord-018265-twp33bb6	484	38	209	209	CD
cord-018265-twp33bb6	484	39	]	]	-RRB-
cord-018265-twp33bb6	484	40	.	.	.
cord-018265-twp33bb6	485	1	This	this	DT
cord-018265-twp33bb6	485	2	could	could	MD
cord-018265-twp33bb6	485	3	be	be	VB
cord-018265-twp33bb6	485	4	complemented	complement	VBN
cord-018265-twp33bb6	485	5	with	with	IN
cord-018265-twp33bb6	485	6	an	an	DT
cord-018265-twp33bb6	485	7	early	early	JJ
cord-018265-twp33bb6	485	8	priming	priming	NN
cord-018265-twp33bb6	485	9	of	of	IN
cord-018265-twp33bb6	485	10	the	the	DT
cord-018265-twp33bb6	485	11	"	"	``
cord-018265-twp33bb6	485	12	immature	immature	JJ
cord-018265-twp33bb6	485	13	"	"	''
cord-018265-twp33bb6	485	14	immune	immune	JJ
cord-018265-twp33bb6	485	15	system	system	NN
cord-018265-twp33bb6	485	16	of	of	IN
cord-018265-twp33bb6	485	17	the	the	DT
cord-018265-twp33bb6	485	18	newborn	newborn	NN
cord-018265-twp33bb6	485	19	by	by	IN
cord-018265-twp33bb6	485	20	DNA	dna	NN
cord-018265-twp33bb6	485	21	vaccination	vaccination	NN
cord-018265-twp33bb6	485	22	,	,	,
cord-018265-twp33bb6	485	23	followed	follow	VBN
cord-018265-twp33bb6	485	24	by	by	IN
cord-018265-twp33bb6	485	25	a	a	DT
cord-018265-twp33bb6	485	26	boost	boost	NN
cord-018265-twp33bb6	485	27	during	during	IN
cord-018265-twp33bb6	485	28	the	the	DT
cord-018265-twp33bb6	485	29	second	second	JJ
cord-018265-twp33bb6	485	30	half	half	NN
cord-018265-twp33bb6	485	31	of	of	IN
cord-018265-twp33bb6	485	32	the	the	DT
cord-018265-twp33bb6	485	33	first	first	JJ
cord-018265-twp33bb6	485	34	year	year	NN
cord-018265-twp33bb6	485	35	or	or	CC
cord-018265-twp33bb6	485	36	later	later	RB
cord-018265-twp33bb6	485	37	in	in	IN
cord-018265-twp33bb6	485	38	life	life	NN
cord-018265-twp33bb6	485	39	[	[	-LRB-
cord-018265-twp33bb6	485	40	203	203	CD
cord-018265-twp33bb6	485	41	]	]	-RRB-
cord-018265-twp33bb6	485	42	.	.	.
cord-018265-twp33bb6	486	1	Poly	poly	NN
cord-018265-twp33bb6	486	2	-	-	HYPH
cord-018265-twp33bb6	486	3	pathology	pathology	NN
cord-018265-twp33bb6	486	4	and	and	CC
cord-018265-twp33bb6	486	5	multiple	multiple	JJ
cord-018265-twp33bb6	486	6	organ	organ	NN
cord-018265-twp33bb6	486	7	failure	failure	NN
cord-018265-twp33bb6	486	8	is	be	VBZ
cord-018265-twp33bb6	486	9	the	the	DT
cord-018265-twp33bb6	486	10	rule	rule	NN
cord-018265-twp33bb6	486	11	rather	rather	RB
cord-018265-twp33bb6	486	12	than	than	IN
cord-018265-twp33bb6	486	13	the	the	DT
cord-018265-twp33bb6	486	14	exception	exception	NN
cord-018265-twp33bb6	486	15	in	in	IN
cord-018265-twp33bb6	486	16	aging	age	VBG
cord-018265-twp33bb6	486	17	individuals	individual	NNS
cord-018265-twp33bb6	486	18	.	.	.
cord-018265-twp33bb6	487	1	Thus	thus	RB
cord-018265-twp33bb6	487	2	,	,	,
cord-018265-twp33bb6	487	3	many	many	JJ
cord-018265-twp33bb6	487	4	systems	system	NNS
cord-018265-twp33bb6	487	5	are	be	VBP
cord-018265-twp33bb6	487	6	affected	affect	VBN
cord-018265-twp33bb6	487	7	(	(	-LRB-
cord-018265-twp33bb6	487	8	e.g.	e.g.	RB
cord-018265-twp33bb6	487	9	,	,	,
cord-018265-twp33bb6	487	10	endocrine	endocrine	JJ
cord-018265-twp33bb6	487	11	,	,	,
cord-018265-twp33bb6	487	12	cardiovascular	cardiovascular	JJ
cord-018265-twp33bb6	487	13	)	)	-RRB-
cord-018265-twp33bb6	487	14	,	,	,
cord-018265-twp33bb6	487	15	and	and	CC
cord-018265-twp33bb6	487	16	the	the	DT
cord-018265-twp33bb6	487	17	immune	immune	JJ
cord-018265-twp33bb6	487	18	system	system	NN
cord-018265-twp33bb6	487	19	is	be	VBZ
cord-018265-twp33bb6	487	20	not	not	RB
cord-018265-twp33bb6	487	21	an	an	DT
cord-018265-twp33bb6	487	22	exception	exception	NN
cord-018265-twp33bb6	487	23	.	.	.
cord-018265-twp33bb6	488	1	The	the	DT
cord-018265-twp33bb6	488	2	mechanisms	mechanism	NNS
cord-018265-twp33bb6	488	3	involved	involve	VBN
cord-018265-twp33bb6	488	4	in	in	IN
cord-018265-twp33bb6	488	5	the	the	DT
cord-018265-twp33bb6	488	6	immune	immune	JJ
cord-018265-twp33bb6	488	7	senescence	senescence	NN
cord-018265-twp33bb6	488	8	process	process	NN
cord-018265-twp33bb6	488	9	,	,	,
cord-018265-twp33bb6	488	10	which	which	WDT
cord-018265-twp33bb6	488	11	in	in	IN
cord-018265-twp33bb6	488	12	turn	turn	NN
cord-018265-twp33bb6	488	13	may	may	MD
cord-018265-twp33bb6	488	14	lead	lead	VB
cord-018265-twp33bb6	488	15	to	to	IN
cord-018265-twp33bb6	488	16	poor	poor	JJ
cord-018265-twp33bb6	488	17	response	response	NN
cord-018265-twp33bb6	488	18	to	to	IN
cord-018265-twp33bb6	488	19	vaccination	vaccination	NN
cord-018265-twp33bb6	488	20	,	,	,
cord-018265-twp33bb6	488	21	are	be	VBP
cord-018265-twp33bb6	488	22	not	not	RB
cord-018265-twp33bb6	488	23	fully	fully	RB
cord-018265-twp33bb6	488	24	understood	understand	VBN
cord-018265-twp33bb6	488	25	.	.	.
cord-018265-twp33bb6	489	1	However	however	RB
cord-018265-twp33bb6	489	2	,	,	,
cord-018265-twp33bb6	489	3	it	-PRON-	PRP
cord-018265-twp33bb6	489	4	is	be	VBZ
cord-018265-twp33bb6	489	5	clear	clear	JJ
cord-018265-twp33bb6	489	6	that	that	IN
cord-018265-twp33bb6	489	7	responses	response	NNS
cord-018265-twp33bb6	489	8	against	against	IN
cord-018265-twp33bb6	489	9	certain	certain	JJ
cord-018265-twp33bb6	489	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	489	11	are	be	VBP
cord-018265-twp33bb6	489	12	more	more	RBR
cord-018265-twp33bb6	489	13	affected	affect	VBN
cord-018265-twp33bb6	489	14	by	by	IN
cord-018265-twp33bb6	489	15	immune	immune	JJ
cord-018265-twp33bb6	489	16	senescence	senescence	NN
cord-018265-twp33bb6	489	17	than	than	IN
cord-018265-twp33bb6	489	18	others	other	NNS
cord-018265-twp33bb6	489	19	(	(	-LRB-
cord-018265-twp33bb6	489	20	e.g.	e.g.	RB
cord-018265-twp33bb6	489	21	,	,	,
cord-018265-twp33bb6	489	22	PS	PS	NNP
cord-018265-twp33bb6	489	23	-	-	HYPH
cord-018265-twp33bb6	489	24	based	base	VBN
cord-018265-twp33bb6	489	25	vaccines	vaccine	NNS
cord-018265-twp33bb6	489	26	against	against	IN
cord-018265-twp33bb6	489	27	S.	S.	NNP
cord-018265-twp33bb6	489	28	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	489	29	)	)	-RRB-
cord-018265-twp33bb6	489	30	[	[	-LRB-
cord-018265-twp33bb6	489	31	210	210	CD
cord-018265-twp33bb6	489	32	]	]	-RRB-
cord-018265-twp33bb6	489	33	.	.	.
cord-018265-twp33bb6	490	1	In	in	IN
cord-018265-twp33bb6	490	2	contrast	contrast	NN
cord-018265-twp33bb6	490	3	,	,	,
cord-018265-twp33bb6	490	4	the	the	DT
cord-018265-twp33bb6	490	5	responses	response	NNS
cord-018265-twp33bb6	490	6	to	to	IN
cord-018265-twp33bb6	490	7	a	a	DT
cord-018265-twp33bb6	490	8	boost	boost	NN
cord-018265-twp33bb6	490	9	dose	dose	NN
cord-018265-twp33bb6	490	10	of	of	IN
cord-018265-twp33bb6	490	11	the	the	DT
cord-018265-twp33bb6	490	12	anti	anti	JJ
cord-018265-twp33bb6	490	13	-	-	JJ
cord-018265-twp33bb6	490	14	tetanus	tetanus	JJ
cord-018265-twp33bb6	490	15	vaccine	vaccine	NN
cord-018265-twp33bb6	490	16	are	be	VBP
cord-018265-twp33bb6	490	17	hardly	hardly	RB
cord-018265-twp33bb6	490	18	affected	affect	VBN
cord-018265-twp33bb6	490	19	by	by	IN
cord-018265-twp33bb6	490	20	age	age	NN
cord-018265-twp33bb6	490	21	[	[	-LRB-
cord-018265-twp33bb6	490	22	211	211	CD
cord-018265-twp33bb6	490	23	]	]	-RRB-
cord-018265-twp33bb6	490	24	.	.	.
cord-018265-twp33bb6	491	1	A	a	DT
cord-018265-twp33bb6	491	2	rapid	rapid	JJ
cord-018265-twp33bb6	491	3	decline	decline	NN
cord-018265-twp33bb6	491	4	of	of	IN
cord-018265-twp33bb6	491	5	antibody	antibody	NN
cord-018265-twp33bb6	491	6	responses	response	NNS
cord-018265-twp33bb6	491	7	,	,	,
cord-018265-twp33bb6	491	8	together	together	RB
cord-018265-twp33bb6	491	9	with	with	IN
cord-018265-twp33bb6	491	10	a	a	DT
cord-018265-twp33bb6	491	11	relative	relative	JJ
cord-018265-twp33bb6	491	12	restriction	restriction	NN
cord-018265-twp33bb6	491	13	of	of	IN
cord-018265-twp33bb6	491	14	the	the	DT
cord-018265-twp33bb6	491	15	T	t	NN
cord-018265-twp33bb6	491	16	-	-	HYPH
cord-018265-twp33bb6	491	17	cell	cell	NN
cord-018265-twp33bb6	491	18	repertoire	repertoire	NN
cord-018265-twp33bb6	491	19	is	be	VBZ
cord-018265-twp33bb6	491	20	characteristic	characteristic	JJ
cord-018265-twp33bb6	491	21	of	of	IN
cord-018265-twp33bb6	491	22	the	the	DT
cord-018265-twp33bb6	491	23	immune	immune	JJ
cord-018265-twp33bb6	491	24	senescence	senescence	NN
cord-018265-twp33bb6	491	25	process	process	NN
cord-018265-twp33bb6	491	26	.	.	.
cord-018265-twp33bb6	492	1	This	this	DT
cord-018265-twp33bb6	492	2	restriction	restriction	NN
cord-018265-twp33bb6	492	3	and	and	CC
cord-018265-twp33bb6	492	4	the	the	DT
cord-018265-twp33bb6	492	5	reduction	reduction	NN
cord-018265-twp33bb6	492	6	in	in	IN
cord-018265-twp33bb6	492	7	the	the	DT
cord-018265-twp33bb6	492	8	pool	pool	NN
cord-018265-twp33bb6	492	9	of	of	IN
cord-018265-twp33bb6	492	10	naïve	naïve	JJ
cord-018265-twp33bb6	492	11	cells	cell	NNS
cord-018265-twp33bb6	492	12	can	can	MD
cord-018265-twp33bb6	492	13	explain	explain	VB
cord-018265-twp33bb6	492	14	the	the	DT
cord-018265-twp33bb6	492	15	poor	poor	JJ
cord-018265-twp33bb6	492	16	CD4	CD4	NNP
cord-018265-twp33bb6	492	17	+	+	CC
cord-018265-twp33bb6	492	18	T	t	NN
cord-018265-twp33bb6	492	19	cell	cell	NN
cord-018265-twp33bb6	492	20	responses	response	NNS
cord-018265-twp33bb6	492	21	against	against	IN
cord-018265-twp33bb6	492	22	antigens	antigen	NNS
cord-018265-twp33bb6	492	23	that	that	WDT
cord-018265-twp33bb6	492	24	are	be	VBP
cord-018265-twp33bb6	492	25	cross	cross	NN
cord-018265-twp33bb6	492	26	-	-	JJ
cord-018265-twp33bb6	492	27	reacting	react	VBG
cord-018265-twp33bb6	492	28	with	with	IN
cord-018265-twp33bb6	492	29	proteins	protein	NNS
cord-018265-twp33bb6	492	30	which	which	WDT
cord-018265-twp33bb6	492	31	were	be	VBD
cord-018265-twp33bb6	492	32	seen	see	VBN
cord-018265-twp33bb6	492	33	earlier	early	RBR
cord-018265-twp33bb6	492	34	in	in	IN
cord-018265-twp33bb6	492	35	life	life	NN
cord-018265-twp33bb6	492	36	.	.	.
cord-018265-twp33bb6	493	1	In	in	IN
cord-018265-twp33bb6	493	2	contrast	contrast	NN
cord-018265-twp33bb6	493	3	,	,	,
cord-018265-twp33bb6	493	4	T	T	NNP
cord-018265-twp33bb6	493	5	-	-	HYPH
cord-018265-twp33bb6	493	6	cells	cell	NNS
cord-018265-twp33bb6	493	7	responses	response	NNS
cord-018265-twp33bb6	493	8	of	of	IN
cord-018265-twp33bb6	493	9	healthy	healthy	JJ
cord-018265-twp33bb6	493	10	elderly	elderly	JJ
cord-018265-twp33bb6	493	11	individuals	individual	NNS
cord-018265-twp33bb6	493	12	to	to	IN
cord-018265-twp33bb6	493	13	new	new	JJ
cord-018265-twp33bb6	493	14	antigens	antigen	NNS
cord-018265-twp33bb6	493	15	are	be	VBP
cord-018265-twp33bb6	493	16	often	often	RB
cord-018265-twp33bb6	493	17	unaffected	unaffected	JJ
cord-018265-twp33bb6	493	18	.	.	.
cord-018265-twp33bb6	494	1	Nevertheless	nevertheless	RB
cord-018265-twp33bb6	494	2	,	,	,
cord-018265-twp33bb6	494	3	the	the	DT
cord-018265-twp33bb6	494	4	overall	overall	JJ
cord-018265-twp33bb6	494	5	response	response	NN
cord-018265-twp33bb6	494	6	to	to	IN
cord-018265-twp33bb6	494	7	vaccination	vaccination	NN
cord-018265-twp33bb6	494	8	in	in	IN
cord-018265-twp33bb6	494	9	the	the	DT
cord-018265-twp33bb6	494	10	elderly	elderly	JJ
cord-018265-twp33bb6	494	11	is	be	VBZ
cord-018265-twp33bb6	494	12	less	less	RBR
cord-018265-twp33bb6	494	13	efficient	efficient	JJ
cord-018265-twp33bb6	494	14	than	than	IN
cord-018265-twp33bb6	494	15	in	in	IN
cord-018265-twp33bb6	494	16	young	young	JJ
cord-018265-twp33bb6	494	17	adults	adult	NNS
cord-018265-twp33bb6	494	18	,	,	,
cord-018265-twp33bb6	494	19	making	make	VBG
cord-018265-twp33bb6	494	20	more	more	RBR
cord-018265-twp33bb6	494	21	vigorous	vigorous	JJ
cord-018265-twp33bb6	494	22	approaches	approach	NNS
cord-018265-twp33bb6	494	23	necessary	necessary	JJ
cord-018265-twp33bb6	494	24	(	(	-LRB-
cord-018265-twp33bb6	494	25	Fig	fig	NN
cord-018265-twp33bb6	494	26	.	.	NNP
cord-018265-twp33bb6	494	27	2	2	CD
cord-018265-twp33bb6	494	28	)	)	-RRB-
cord-018265-twp33bb6	494	29	.	.	.
cord-018265-twp33bb6	495	1	In	in	IN
cord-018265-twp33bb6	495	2	the	the	DT
cord-018265-twp33bb6	495	3	case	case	NN
cord-018265-twp33bb6	495	4	of	of	IN
cord-018265-twp33bb6	495	5	influenza	influenza	NN
cord-018265-twp33bb6	495	6	,	,	,
cord-018265-twp33bb6	495	7	the	the	DT
cord-018265-twp33bb6	495	8	actual	actual	JJ
cord-018265-twp33bb6	495	9	strategy	strategy	NN
cord-018265-twp33bb6	495	10	is	be	VBZ
cord-018265-twp33bb6	495	11	annual	annual	JJ
cord-018265-twp33bb6	495	12	re	re	NN
cord-018265-twp33bb6	495	13	-	-	NN
cord-018265-twp33bb6	495	14	vaccination	vaccination	NN
cord-018265-twp33bb6	495	15	.	.	.
cord-018265-twp33bb6	496	1	However	however	RB
cord-018265-twp33bb6	496	2	,	,	,
cord-018265-twp33bb6	496	3	there	there	EX
cord-018265-twp33bb6	496	4	are	be	VBP
cord-018265-twp33bb6	496	5	concerns	concern	NNS
cord-018265-twp33bb6	496	6	regarding	regard	VBG
cord-018265-twp33bb6	496	7	the	the	DT
cord-018265-twp33bb6	496	8	capacity	capacity	NN
cord-018265-twp33bb6	496	9	to	to	TO
cord-018265-twp33bb6	496	10	increase	increase	VB
cord-018265-twp33bb6	496	11	antibodies	antibody	NNS
cord-018265-twp33bb6	496	12	with	with	IN
cord-018265-twp33bb6	496	13	proper	proper	JJ
cord-018265-twp33bb6	496	14	specificity	specificity	NN
cord-018265-twp33bb6	496	15	against	against	IN
cord-018265-twp33bb6	496	16	re	re	JJ
cord-018265-twp33bb6	496	17	-	-	JJ
cord-018265-twp33bb6	496	18	assorted	assorted	JJ
cord-018265-twp33bb6	496	19	viruses	virus	NNS
cord-018265-twp33bb6	496	20	in	in	IN
cord-018265-twp33bb6	496	21	aging	age	VBG
cord-018265-twp33bb6	496	22	adults	adult	NNS
cord-018265-twp33bb6	496	23	who	who	WP
cord-018265-twp33bb6	496	24	have	have	VBP
cord-018265-twp33bb6	496	25	been	be	VBN
cord-018265-twp33bb6	496	26	repeatedly	repeatedly	RB
cord-018265-twp33bb6	496	27	infected	infect	VBN
cord-018265-twp33bb6	496	28	or	or	CC
cord-018265-twp33bb6	496	29	immunized	immunize	VBN
cord-018265-twp33bb6	496	30	.	.	.
cord-018265-twp33bb6	497	1	After	after	IN
cord-018265-twp33bb6	497	2	exposure	exposure	NN
cord-018265-twp33bb6	497	3	to	to	IN
cord-018265-twp33bb6	497	4	a	a	DT
cord-018265-twp33bb6	497	5	new	new	JJ
cord-018265-twp33bb6	497	6	,	,	,
cord-018265-twp33bb6	497	7	but	but	CC
cord-018265-twp33bb6	497	8	cross	cross	NN
cord-018265-twp33bb6	497	9	-	-	JJ
cord-018265-twp33bb6	497	10	reacting	react	VBG
cord-018265-twp33bb6	497	11	antigenic	antigenic	JJ
cord-018265-twp33bb6	497	12	variant	variant	NN
cord-018265-twp33bb6	497	13	,	,	,
cord-018265-twp33bb6	497	14	such	such	JJ
cord-018265-twp33bb6	497	15	individuals	individual	NNS
cord-018265-twp33bb6	497	16	may	may	MD
cord-018265-twp33bb6	497	17	respond	respond	VB
cord-018265-twp33bb6	497	18	by	by	IN
cord-018265-twp33bb6	497	19	producing	produce	VBG
cord-018265-twp33bb6	497	20	antibodies	antibody	NNS
cord-018265-twp33bb6	497	21	.	.	.
cord-018265-twp33bb6	498	1	However	however	RB
cord-018265-twp33bb6	498	2	,	,	,
cord-018265-twp33bb6	498	3	these	these	DT
cord-018265-twp33bb6	498	4	antibodies	antibody	NNS
cord-018265-twp33bb6	498	5	could	could	MD
cord-018265-twp33bb6	498	6	be	be	VB
cord-018265-twp33bb6	498	7	primarily	primarily	RB
cord-018265-twp33bb6	498	8	directed	direct	VBN
cord-018265-twp33bb6	498	9	against	against	IN
cord-018265-twp33bb6	498	10	influenza	influenza	NN
cord-018265-twp33bb6	498	11	strains	strain	NNS
cord-018265-twp33bb6	498	12	,	,	,
cord-018265-twp33bb6	498	13	which	which	WDT
cord-018265-twp33bb6	498	14	were	be	VBD
cord-018265-twp33bb6	498	15	encountered	encounter	VBN
cord-018265-twp33bb6	498	16	earlier	early	RBR
cord-018265-twp33bb6	498	17	in	in	IN
cord-018265-twp33bb6	498	18	life	life	NN
cord-018265-twp33bb6	498	19	.	.	.
cord-018265-twp33bb6	499	1	Figure	figure	NN
cord-018265-twp33bb6	499	2	2	2	CD
cord-018265-twp33bb6	499	3	.	.	.
cord-018265-twp33bb6	500	1	Factors	factor	NNS
cord-018265-twp33bb6	500	2	affecting	affect	VBG
cord-018265-twp33bb6	500	3	the	the	DT
cord-018265-twp33bb6	500	4	responses	response	NNS
cord-018265-twp33bb6	500	5	in	in	IN
cord-018265-twp33bb6	500	6	young	young	JJ
cord-018265-twp33bb6	500	7	adults	adult	NNS
cord-018265-twp33bb6	500	8	and	and	CC
cord-018265-twp33bb6	500	9	aging	age	VBG
cord-018265-twp33bb6	500	10	individuals	individual	NNS
cord-018265-twp33bb6	500	11	after	after	IN
cord-018265-twp33bb6	500	12	vaccination	vaccination	NN
cord-018265-twp33bb6	500	13	.	.	.
cord-018265-twp33bb6	501	1	The	the	DT
cord-018265-twp33bb6	501	2	process	process	NN
cord-018265-twp33bb6	501	3	of	of	IN
cord-018265-twp33bb6	501	4	immune	immune	JJ
cord-018265-twp33bb6	501	5	senescence	senescence	NN
cord-018265-twp33bb6	501	6	impairs	impair	VBZ
cord-018265-twp33bb6	501	7	host	host	NN
cord-018265-twp33bb6	501	8	response	response	NN
cord-018265-twp33bb6	501	9	to	to	IN
cord-018265-twp33bb6	501	10	both	both	DT
cord-018265-twp33bb6	501	11	infection	infection	NN
cord-018265-twp33bb6	501	12	and	and	CC
cord-018265-twp33bb6	501	13	vaccination	vaccination	NN
cord-018265-twp33bb6	501	14	.	.	.
cord-018265-twp33bb6	502	1	This	this	DT
cord-018265-twp33bb6	502	2	critical	critical	JJ
cord-018265-twp33bb6	502	3	issue	issue	NN
cord-018265-twp33bb6	502	4	needs	need	VBZ
cord-018265-twp33bb6	502	5	to	to	TO
cord-018265-twp33bb6	502	6	be	be	VB
cord-018265-twp33bb6	502	7	considered	consider	VBN
cord-018265-twp33bb6	502	8	during	during	IN
cord-018265-twp33bb6	502	9	vaccine	vaccine	NN
cord-018265-twp33bb6	502	10	design	design	NN
cord-018265-twp33bb6	502	11	and	and	CC
cord-018265-twp33bb6	502	12	will	will	MD
cord-018265-twp33bb6	502	13	require	require	VB
cord-018265-twp33bb6	502	14	the	the	DT
cord-018265-twp33bb6	502	15	development	development	NN
cord-018265-twp33bb6	502	16	of	of	IN
cord-018265-twp33bb6	502	17	special	special	JJ
cord-018265-twp33bb6	502	18	approaches	approach	NNS
cord-018265-twp33bb6	502	19	.	.	.
cord-018265-twp33bb6	503	1	For	for	IN
cord-018265-twp33bb6	503	2	example	example	NN
cord-018265-twp33bb6	503	3	,	,	,
cord-018265-twp33bb6	503	4	individuals	individual	NNS
cord-018265-twp33bb6	503	5	previously	previously	RB
cord-018265-twp33bb6	503	6	exposed	expose	VBN
cord-018265-twp33bb6	503	7	to	to	IN
cord-018265-twp33bb6	503	8	the	the	DT
cord-018265-twp33bb6	503	9	"	"	``
cord-018265-twp33bb6	503	10	old	old	JJ
cord-018265-twp33bb6	503	11	"	"	''
cord-018265-twp33bb6	503	12	H1N1	H1N1	NNP
cord-018265-twp33bb6	503	13	influenza	influenza	NN
cord-018265-twp33bb6	503	14	strain	strain	NN
cord-018265-twp33bb6	503	15	(	(	-LRB-
cord-018265-twp33bb6	503	16	i.e.	i.e.	FW
cord-018265-twp33bb6	503	17	,	,	,
cord-018265-twp33bb6	503	18	50	50	CD
cord-018265-twp33bb6	503	19	years	year	NNS
cord-018265-twp33bb6	503	20	ago	ago	RB
cord-018265-twp33bb6	503	21	)	)	-RRB-
cord-018265-twp33bb6	503	22	,	,	,
cord-018265-twp33bb6	503	23	may	may	MD
cord-018265-twp33bb6	503	24	respond	respond	VB
cord-018265-twp33bb6	503	25	differently	differently	RB
cord-018265-twp33bb6	503	26	from	from	IN
cord-018265-twp33bb6	503	27	naïve	naïve	JJ
cord-018265-twp33bb6	503	28	adults	adult	NNS
cord-018265-twp33bb6	503	29	who	who	WP
cord-018265-twp33bb6	503	30	are	be	VBP
cord-018265-twp33bb6	503	31	vaccinated	vaccinate	VBN
cord-018265-twp33bb6	503	32	with	with	IN
cord-018265-twp33bb6	503	33	a	a	DT
cord-018265-twp33bb6	503	34	"	"	``
cord-018265-twp33bb6	503	35	new	new	JJ
cord-018265-twp33bb6	503	36	"	"	''
cord-018265-twp33bb6	503	37	H1N1	H1N1	NNP
cord-018265-twp33bb6	503	38	strain	strain	NN
cord-018265-twp33bb6	503	39	which	which	WDT
cord-018265-twp33bb6	503	40	have	have	VBP
cord-018265-twp33bb6	503	41	accumulated	accumulate	VBN
cord-018265-twp33bb6	503	42	different	different	JJ
cord-018265-twp33bb6	503	43	mutations	mutation	NNS
cord-018265-twp33bb6	503	44	.	.	.
cord-018265-twp33bb6	504	1	The	the	DT
cord-018265-twp33bb6	504	2	former	former	JJ
cord-018265-twp33bb6	504	3	might	may	MD
cord-018265-twp33bb6	504	4	produce	produce	VB
cord-018265-twp33bb6	504	5	antibodies	antibody	NNS
cord-018265-twp33bb6	504	6	against	against	IN
cord-018265-twp33bb6	504	7	the	the	DT
cord-018265-twp33bb6	504	8	HA	HA	NNP
cord-018265-twp33bb6	504	9	of	of	IN
cord-018265-twp33bb6	504	10	the	the	DT
cord-018265-twp33bb6	504	11	"	"	``
cord-018265-twp33bb6	504	12	old	old	JJ
cord-018265-twp33bb6	504	13	"	"	''
cord-018265-twp33bb6	504	14	H1N1	H1N1	NNP
cord-018265-twp33bb6	504	15	strain	strain	VBP
cord-018265-twp33bb6	504	16	rather	rather	RB
cord-018265-twp33bb6	504	17	than	than	IN
cord-018265-twp33bb6	504	18	to	to	IN
cord-018265-twp33bb6	504	19	the	the	DT
cord-018265-twp33bb6	504	20	cross	cross	NN
cord-018265-twp33bb6	504	21	-	-	JJ
cord-018265-twp33bb6	504	22	reacting	react	VBG
cord-018265-twp33bb6	504	23	epitopes	epitope	NNS
cord-018265-twp33bb6	504	24	of	of	IN
cord-018265-twp33bb6	504	25	the	the	DT
cord-018265-twp33bb6	504	26	new	new	JJ
cord-018265-twp33bb6	504	27	strain	strain	NN
cord-018265-twp33bb6	504	28	[	[	-LRB-
cord-018265-twp33bb6	504	29	212	212	CD
cord-018265-twp33bb6	504	30	]	]	-RRB-
cord-018265-twp33bb6	504	31	.	.	.
cord-018265-twp33bb6	505	1	This	this	DT
cord-018265-twp33bb6	505	2	is	be	VBZ
cord-018265-twp33bb6	505	3	phenomenon	phenomenon	NN
cord-018265-twp33bb6	505	4	is	be	VBZ
cord-018265-twp33bb6	505	5	the	the	DT
cord-018265-twp33bb6	505	6	so	so	RB
cord-018265-twp33bb6	505	7	-	-	HYPH
cord-018265-twp33bb6	505	8	called	call	VBN
cord-018265-twp33bb6	505	9	"	"	``
cord-018265-twp33bb6	505	10	original	original	JJ
cord-018265-twp33bb6	505	11	antigenic	antigenic	JJ
cord-018265-twp33bb6	505	12	sin	sin	NN
cord-018265-twp33bb6	505	13	"	"	''
cord-018265-twp33bb6	505	14	[	[	-LRB-
cord-018265-twp33bb6	505	15	119	119	CD
cord-018265-twp33bb6	505	16	]	]	-RRB-
cord-018265-twp33bb6	505	17	.	.	.
cord-018265-twp33bb6	506	1	On	on	IN
cord-018265-twp33bb6	506	2	the	the	DT
cord-018265-twp33bb6	506	3	basis	basis	NN
cord-018265-twp33bb6	506	4	of	of	IN
cord-018265-twp33bb6	506	5	this	this	DT
cord-018265-twp33bb6	506	6	observations	observation	NNS
cord-018265-twp33bb6	506	7	,	,	,
cord-018265-twp33bb6	506	8	it	-PRON-	PRP
cord-018265-twp33bb6	506	9	was	be	VBD
cord-018265-twp33bb6	506	10	proposed	propose	VBN
cord-018265-twp33bb6	506	11	that	that	IN
cord-018265-twp33bb6	506	12	variations	variation	NNS
cord-018265-twp33bb6	506	13	in	in	IN
cord-018265-twp33bb6	506	14	vaccine	vaccine	NN
cord-018265-twp33bb6	506	15	efficacy	efficacy	NN
cord-018265-twp33bb6	506	16	might	may	MD
cord-018265-twp33bb6	506	17	be	be	VB
cord-018265-twp33bb6	506	18	due	due	JJ
cord-018265-twp33bb6	506	19	to	to	IN
cord-018265-twp33bb6	506	20	differences	difference	NNS
cord-018265-twp33bb6	506	21	in	in	IN
cord-018265-twp33bb6	506	22	the	the	DT
cord-018265-twp33bb6	506	23	antigenic	antigenic	JJ
cord-018265-twp33bb6	506	24	distance	distance	NN
cord-018265-twp33bb6	506	25	between	between	IN
cord-018265-twp33bb6	506	26	the	the	DT
cord-018265-twp33bb6	506	27	vaccine	vaccine	NN
cord-018265-twp33bb6	506	28	strains	strain	NNS
cord-018265-twp33bb6	506	29	and	and	CC
cord-018265-twp33bb6	506	30	the	the	DT
cord-018265-twp33bb6	506	31	epidemic	epidemic	NN
cord-018265-twp33bb6	506	32	strains	strain	NNS
cord-018265-twp33bb6	506	33	responsible	responsible	JJ
cord-018265-twp33bb6	506	34	for	for	IN
cord-018265-twp33bb6	506	35	influenza	influenza	NN
cord-018265-twp33bb6	506	36	outbreaks	outbreak	NNS
cord-018265-twp33bb6	506	37	[	[	-LRB-
cord-018265-twp33bb6	506	38	213	213	CD
cord-018265-twp33bb6	506	39	]	]	-RRB-
cord-018265-twp33bb6	506	40	.	.	.
cord-018265-twp33bb6	507	1	However	however	RB
cord-018265-twp33bb6	507	2	,	,	,
cord-018265-twp33bb6	507	3	this	this	DT
cord-018265-twp33bb6	507	4	hypothesis	hypothesis	NN
cord-018265-twp33bb6	507	5	was	be	VBD
cord-018265-twp33bb6	507	6	not	not	RB
cord-018265-twp33bb6	507	7	confirmed	confirm	VBN
cord-018265-twp33bb6	507	8	by	by	IN
cord-018265-twp33bb6	507	9	epidemiologic	epidemiologic	JJ
cord-018265-twp33bb6	507	10	studies	study	NNS
cord-018265-twp33bb6	507	11	[	[	-LRB-
cord-018265-twp33bb6	507	12	214	214	CD
cord-018265-twp33bb6	507	13	]	]	-RRB-
cord-018265-twp33bb6	507	14	.	.	.
cord-018265-twp33bb6	508	1	Even	even	RB
cord-018265-twp33bb6	508	2	more	more	JJR
cord-018265-twp33bb6	508	3	,	,	,
cord-018265-twp33bb6	508	4	individuals	individual	NNS
cord-018265-twp33bb6	508	5	aged	age	VBN
cord-018265-twp33bb6	508	6	65	65	CD
cord-018265-twp33bb6	508	7	years	year	NNS
cord-018265-twp33bb6	508	8	or	or	CC
cord-018265-twp33bb6	508	9	older	old	JJR
cord-018265-twp33bb6	508	10	who	who	WP
cord-018265-twp33bb6	508	11	were	be	VBD
cord-018265-twp33bb6	508	12	annually	annually	RB
cord-018265-twp33bb6	508	13	vaccinated	vaccinate	VBN
cord-018265-twp33bb6	508	14	showed	show	VBD
cord-018265-twp33bb6	508	15	a	a	DT
cord-018265-twp33bb6	508	16	significantly	significantly	RB
cord-018265-twp33bb6	508	17	reduced	reduce	VBN
cord-018265-twp33bb6	508	18	mortality	mortality	NN
cord-018265-twp33bb6	508	19	risk	risk	NN
cord-018265-twp33bb6	508	20	.	.	.
cord-018265-twp33bb6	509	1	Therefore	therefore	RB
cord-018265-twp33bb6	509	2	,	,	,
cord-018265-twp33bb6	509	3	until	until	IN
cord-018265-twp33bb6	509	4	now	now	RB
cord-018265-twp33bb6	509	5	,	,	,
cord-018265-twp33bb6	509	6	it	-PRON-	PRP
cord-018265-twp33bb6	509	7	seems	seem	VBZ
cord-018265-twp33bb6	509	8	that	that	IN
cord-018265-twp33bb6	509	9	the	the	DT
cord-018265-twp33bb6	509	10	antigenic	antigenic	JJ
cord-018265-twp33bb6	509	11	sin	sin	NN
cord-018265-twp33bb6	509	12	does	do	VBZ
cord-018265-twp33bb6	509	13	not	not	RB
cord-018265-twp33bb6	509	14	represent	represent	VB
cord-018265-twp33bb6	509	15	a	a	DT
cord-018265-twp33bb6	509	16	major	major	JJ
cord-018265-twp33bb6	509	17	practical	practical	JJ
cord-018265-twp33bb6	509	18	obstacle	obstacle	NN
cord-018265-twp33bb6	509	19	in	in	IN
cord-018265-twp33bb6	509	20	influenza	influenza	NN
cord-018265-twp33bb6	509	21	vaccination	vaccination	NN
cord-018265-twp33bb6	509	22	and	and	CC
cord-018265-twp33bb6	509	23	additional	additional	JJ
cord-018265-twp33bb6	509	24	strategies	strategy	NNS
cord-018265-twp33bb6	509	25	may	may	MD
cord-018265-twp33bb6	509	26	not	not	RB
cord-018265-twp33bb6	509	27	be	be	VB
cord-018265-twp33bb6	509	28	required	require	VBN
cord-018265-twp33bb6	509	29	.	.	.
cord-018265-twp33bb6	510	1	Despite	despite	IN
cord-018265-twp33bb6	510	2	the	the	DT
cord-018265-twp33bb6	510	3	broad	broad	JJ
cord-018265-twp33bb6	510	4	availability	availability	NN
cord-018265-twp33bb6	510	5	of	of	IN
cord-018265-twp33bb6	510	6	vaccines	vaccine	NNS
cord-018265-twp33bb6	510	7	against	against	IN
cord-018265-twp33bb6	510	8	agents	agent	NNS
cord-018265-twp33bb6	510	9	causing	cause	VBG
cord-018265-twp33bb6	510	10	community	community	NN
cord-018265-twp33bb6	510	11	-	-	HYPH
cord-018265-twp33bb6	510	12	acquired	acquire	VBN
cord-018265-twp33bb6	510	13	pneumonia	pneumonia	NN
cord-018265-twp33bb6	510	14	,	,	,
cord-018265-twp33bb6	510	15	they	-PRON-	PRP
cord-018265-twp33bb6	510	16	still	still	RB
cord-018265-twp33bb6	510	17	represent	represent	VBP
cord-018265-twp33bb6	510	18	an	an	DT
cord-018265-twp33bb6	510	19	important	important	JJ
cord-018265-twp33bb6	510	20	cause	cause	NN
cord-018265-twp33bb6	510	21	of	of	IN
cord-018265-twp33bb6	510	22	death	death	NN
cord-018265-twp33bb6	510	23	,	,	,
cord-018265-twp33bb6	510	24	human	human	JJ
cord-018265-twp33bb6	510	25	suffering	suffering	NN
cord-018265-twp33bb6	510	26	and	and	CC
cord-018265-twp33bb6	510	27	economic	economic	JJ
cord-018265-twp33bb6	510	28	losses	loss	NNS
cord-018265-twp33bb6	510	29	.	.	.
cord-018265-twp33bb6	511	1	However	however	RB
cord-018265-twp33bb6	511	2	,	,	,
cord-018265-twp33bb6	511	3	we	-PRON-	PRP
cord-018265-twp33bb6	511	4	have	have	VBP
cord-018265-twp33bb6	511	5	dramatically	dramatically	RB
cord-018265-twp33bb6	511	6	expanded	expand	VBN
cord-018265-twp33bb6	511	7	our	-PRON-	PRP$
cord-018265-twp33bb6	511	8	knowledge	knowledge	NN
cord-018265-twp33bb6	511	9	on	on	IN
cord-018265-twp33bb6	511	10	the	the	DT
cord-018265-twp33bb6	511	11	pathophysiology	pathophysiology	NN
cord-018265-twp33bb6	511	12	of	of	IN
cord-018265-twp33bb6	511	13	diseases	disease	NNS
cord-018265-twp33bb6	511	14	caused	cause	VBN
cord-018265-twp33bb6	511	15	by	by	IN
cord-018265-twp33bb6	511	16	respiratory	respiratory	JJ
cord-018265-twp33bb6	511	17	pathogens	pathogen	NNS
cord-018265-twp33bb6	511	18	,	,	,
cord-018265-twp33bb6	511	19	their	-PRON-	PRP$
cord-018265-twp33bb6	511	20	virulence	virulence	NN
cord-018265-twp33bb6	511	21	factors	factor	NNS
cord-018265-twp33bb6	511	22	and	and	CC
cord-018265-twp33bb6	511	23	the	the	DT
cord-018265-twp33bb6	511	24	effector	effector	NN
cord-018265-twp33bb6	511	25	mechanisms	mechanism	NNS
cord-018265-twp33bb6	511	26	responsible	responsible	JJ
cord-018265-twp33bb6	511	27	for	for	IN
cord-018265-twp33bb6	511	28	their	-PRON-	PRP$
cord-018265-twp33bb6	511	29	clearance	clearance	NN
cord-018265-twp33bb6	511	30	.	.	.
cord-018265-twp33bb6	512	1	It	-PRON-	PRP
cord-018265-twp33bb6	512	2	is	be	VBZ
cord-018265-twp33bb6	512	3	becoming	become	VBG
cord-018265-twp33bb6	512	4	clearer	clear	JJR
cord-018265-twp33bb6	512	5	which	which	WDT
cord-018265-twp33bb6	512	6	microbial	microbial	JJ
cord-018265-twp33bb6	512	7	components	component	NNS
cord-018265-twp33bb6	512	8	are	be	VBP
cord-018265-twp33bb6	512	9	attractive	attractive	JJ
cord-018265-twp33bb6	512	10	as	as	IN
cord-018265-twp33bb6	512	11	vaccine	vaccine	NN
cord-018265-twp33bb6	512	12	targets	target	NNS
cord-018265-twp33bb6	512	13	,	,	,
cord-018265-twp33bb6	512	14	as	as	RB
cord-018265-twp33bb6	512	15	well	well	RB
cord-018265-twp33bb6	512	16	as	as	IN
cord-018265-twp33bb6	512	17	the	the	DT
cord-018265-twp33bb6	512	18	type	type	NN
cord-018265-twp33bb6	512	19	of	of	IN
cord-018265-twp33bb6	512	20	immune	immune	JJ
cord-018265-twp33bb6	512	21	response	response	NN
cord-018265-twp33bb6	512	22	needed	need	VBN
cord-018265-twp33bb6	512	23	to	to	TO
cord-018265-twp33bb6	512	24	confer	confer	VB
cord-018265-twp33bb6	512	25	protection	protection	NN
cord-018265-twp33bb6	512	26	against	against	IN
cord-018265-twp33bb6	512	27	disease	disease	NN
cord-018265-twp33bb6	512	28	.	.	.
cord-018265-twp33bb6	513	1	Thus	thus	RB
cord-018265-twp33bb6	513	2	,	,	,
cord-018265-twp33bb6	513	3	it	-PRON-	PRP
cord-018265-twp33bb6	513	4	is	be	VBZ
cord-018265-twp33bb6	513	5	now	now	RB
cord-018265-twp33bb6	513	6	possible	possible	JJ
cord-018265-twp33bb6	513	7	to	to	TO
cord-018265-twp33bb6	513	8	address	address	VB
cord-018265-twp33bb6	513	9	vaccine	vaccine	NN
cord-018265-twp33bb6	513	10	development	development	NN
cord-018265-twp33bb6	513	11	using	use	VBG
cord-018265-twp33bb6	513	12	rational	rational	JJ
cord-018265-twp33bb6	513	13	rather	rather	RB
cord-018265-twp33bb6	513	14	than	than	IN
cord-018265-twp33bb6	513	15	empiric	empiric	JJ
cord-018265-twp33bb6	513	16	approaches	approach	NNS
cord-018265-twp33bb6	513	17	.	.	.
cord-018265-twp33bb6	514	1	This	this	DT
cord-018265-twp33bb6	514	2	is	be	VBZ
cord-018265-twp33bb6	514	3	facilitated	facilitate	VBN
cord-018265-twp33bb6	514	4	by	by	IN
cord-018265-twp33bb6	514	5	powerful	powerful	JJ
cord-018265-twp33bb6	514	6	bioinformatics	bioinformatic	NNS
cord-018265-twp33bb6	514	7	tools	tool	NNS
cord-018265-twp33bb6	514	8	for	for	IN
cord-018265-twp33bb6	514	9	the	the	DT
cord-018265-twp33bb6	514	10	accurate	accurate	JJ
cord-018265-twp33bb6	514	11	prediction	prediction	NN
cord-018265-twp33bb6	514	12	of	of	IN
cord-018265-twp33bb6	514	13	epitopes	epitope	NNS
cord-018265-twp33bb6	514	14	and	and	CC
cord-018265-twp33bb6	514	15	proteasome	proteasome	NN
cord-018265-twp33bb6	514	16	trimming	trimming	NN
cord-018265-twp33bb6	514	17	[	[	-LRB-
cord-018265-twp33bb6	514	18	215	215	CD
cord-018265-twp33bb6	514	19	]	]	-RRB-
cord-018265-twp33bb6	514	20	[	[	-LRB-
cord-018265-twp33bb6	514	21	216	216	CD
cord-018265-twp33bb6	514	22	]	]	-RRB-
cord-018265-twp33bb6	514	23	[	[	-LRB-
cord-018265-twp33bb6	514	24	217	217	CD
cord-018265-twp33bb6	514	25	]	]	-RRB-
cord-018265-twp33bb6	514	26	,	,	,
cord-018265-twp33bb6	514	27	as	as	RB
cord-018265-twp33bb6	514	28	well	well	RB
cord-018265-twp33bb6	514	29	as	as	IN
cord-018265-twp33bb6	514	30	by	by	IN
cord-018265-twp33bb6	514	31	the	the	DT
cord-018265-twp33bb6	514	32	availability	availability	NN
cord-018265-twp33bb6	514	33	of	of	IN
cord-018265-twp33bb6	514	34	a	a	DT
cord-018265-twp33bb6	514	35	broad	broad	JJ
cord-018265-twp33bb6	514	36	palette	palette	NN
cord-018265-twp33bb6	514	37	of	of	IN
cord-018265-twp33bb6	514	38	immune	immune	JJ
cord-018265-twp33bb6	514	39	modulators	modulator	NNS
cord-018265-twp33bb6	514	40	and	and	CC
cord-018265-twp33bb6	514	41	delivery	delivery	NN
cord-018265-twp33bb6	514	42	systems	system	NNS
cord-018265-twp33bb6	514	43	.	.	.
cord-018265-twp33bb6	515	1	Therefore	therefore	RB
cord-018265-twp33bb6	515	2	,	,	,
cord-018265-twp33bb6	515	3	we	-PRON-	PRP
cord-018265-twp33bb6	515	4	can	can	MD
cord-018265-twp33bb6	515	5	predict	predict	VB
cord-018265-twp33bb6	515	6	that	that	IN
cord-018265-twp33bb6	515	7	new	new	JJ
cord-018265-twp33bb6	515	8	and	and	CC
cord-018265-twp33bb6	515	9	improved	improved	JJ
cord-018265-twp33bb6	515	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	515	11	against	against	IN
cord-018265-twp33bb6	515	12	the	the	DT
cord-018265-twp33bb6	515	13	etiologic	etiologic	JJ
cord-018265-twp33bb6	515	14	agents	agent	NNS
cord-018265-twp33bb6	515	15	of	of	IN
cord-018265-twp33bb6	515	16	community	community	NN
cord-018265-twp33bb6	515	17	-	-	HYPH
cord-018265-twp33bb6	515	18	acquired	acquire	VBN
cord-018265-twp33bb6	515	19	pneumonia	pneumonia	NN
cord-018265-twp33bb6	515	20	will	will	MD
cord-018265-twp33bb6	515	21	considerably	considerably	RB
cord-018265-twp33bb6	515	22	reduce	reduce	VB
cord-018265-twp33bb6	515	23	the	the	DT
cord-018265-twp33bb6	515	24	global	global	JJ
cord-018265-twp33bb6	515	25	impact	impact	NN
cord-018265-twp33bb6	515	26	of	of	IN
cord-018265-twp33bb6	515	27	this	this	DT
cord-018265-twp33bb6	515	28	disease	disease	NN
cord-018265-twp33bb6	515	29	in	in	IN
cord-018265-twp33bb6	515	30	the	the	DT
cord-018265-twp33bb6	515	31	coming	come	VBG
cord-018265-twp33bb6	515	32	years	year	NNS
cord-018265-twp33bb6	515	33	.	.	.
cord-018265-twp33bb6	515	34	 	 	_SP
cord-018265-twp33bb6	516	1	A	a	DT
cord-018265-twp33bb6	516	2	review	review	NN
cord-018265-twp33bb6	516	3	of	of	IN
cord-018265-twp33bb6	516	4	vaccine	vaccine	NN
cord-018265-twp33bb6	516	5	research	research	NN
cord-018265-twp33bb6	516	6	and	and	CC
cord-018265-twp33bb6	516	7	development	development	NN
cord-018265-twp33bb6	516	8	:	:	:
cord-018265-twp33bb6	517	1	Human	human	JJ
cord-018265-twp33bb6	517	2	acute	acute	JJ
cord-018265-twp33bb6	517	3	respiratory	respiratory	JJ
cord-018265-twp33bb6	517	4	infections	infection	NNS
cord-018265-twp33bb6	517	5	Estimates	estimate	NNS
cord-018265-twp33bb6	517	6	of	of	IN
cord-018265-twp33bb6	517	7	world	world	NN
cord-018265-twp33bb6	517	8	-	-	HYPH
cord-018265-twp33bb6	517	9	wide	wide	JJ
cord-018265-twp33bb6	517	10	distribution	distribution	NN
cord-018265-twp33bb6	517	11	of	of	IN
cord-018265-twp33bb6	517	12	child	child	NN
cord-018265-twp33bb6	517	13	deaths	death	NNS
cord-018265-twp33bb6	517	14	from	from	IN
cord-018265-twp33bb6	517	15	acute	acute	JJ
cord-018265-twp33bb6	517	16	respiratory	respiratory	JJ
cord-018265-twp33bb6	517	17	infections	infection	NNS
cord-018265-twp33bb6	517	18	Respiratory	respiratory	JJ
cord-018265-twp33bb6	517	19	viral	viral	JJ
cord-018265-twp33bb6	517	20	vaccines	vaccine	NNS
cord-018265-twp33bb6	517	21	Public	public	JJ
cord-018265-twp33bb6	517	22	health	health	NN
cord-018265-twp33bb6	517	23	.	.	.
cord-018265-twp33bb6	518	1	Will	Will	MD
cord-018265-twp33bb6	518	2	vaccines	vaccine	NNS
cord-018265-twp33bb6	518	3	be	be	VB
cord-018265-twp33bb6	518	4	available	available	JJ
cord-018265-twp33bb6	518	5	for	for	IN
cord-018265-twp33bb6	518	6	the	the	DT
cord-018265-twp33bb6	518	7	next	next	JJ
cord-018265-twp33bb6	518	8	influenza	influenza	NN
cord-018265-twp33bb6	518	9	pandemic	pandemic	NN
cord-018265-twp33bb6	518	10	Novel	novel	JJ
cord-018265-twp33bb6	518	11	generations	generation	NNS
cord-018265-twp33bb6	518	12	of	of	IN
cord-018265-twp33bb6	518	13	influenza	influenza	NN
cord-018265-twp33bb6	518	14	vaccines	vaccine	NNS
cord-018265-twp33bb6	518	15	Safety	Safety	NNP
cord-018265-twp33bb6	518	16	,	,	,
cord-018265-twp33bb6	518	17	reactogenicity	reactogenicity	NN
cord-018265-twp33bb6	518	18	and	and	CC
cord-018265-twp33bb6	518	19	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	518	20	of	of	IN
cord-018265-twp33bb6	518	21	Madin	Madin	NNP
cord-018265-twp33bb6	518	22	Darby	Darby	NNP
cord-018265-twp33bb6	518	23	Canine	Canine	NNP
cord-018265-twp33bb6	518	24	Kidney	Kidney	NNP
cord-018265-twp33bb6	518	25	cell	cell	NN
cord-018265-twp33bb6	518	26	-	-	HYPH
cord-018265-twp33bb6	518	27	derived	derive	VBN
cord-018265-twp33bb6	518	28	inactivated	inactivate	VBN
cord-018265-twp33bb6	518	29	influenza	influenza	NN
cord-018265-twp33bb6	518	30	subunit	subunit	NN
cord-018265-twp33bb6	518	31	vaccine	vaccine	NN
cord-018265-twp33bb6	518	32	.	.	.
cord-018265-twp33bb6	519	1	A	a	DT
cord-018265-twp33bb6	519	2	meta	meta	JJ
cord-018265-twp33bb6	519	3	-	-	HYPH
cord-018265-twp33bb6	519	4	analysis	analysis	NN
cord-018265-twp33bb6	519	5	of	of	IN
cord-018265-twp33bb6	519	6	clinical	clinical	JJ
cord-018265-twp33bb6	519	7	studies	study	NNS
cord-018265-twp33bb6	519	8	Development	Development	NNP
cord-018265-twp33bb6	519	9	of	of	IN
cord-018265-twp33bb6	519	10	a	a	DT
cord-018265-twp33bb6	519	11	Vero	Vero	NNP
cord-018265-twp33bb6	519	12	cell	cell	NN
cord-018265-twp33bb6	519	13	-	-	HYPH
cord-018265-twp33bb6	519	14	derived	derive	VBN
cord-018265-twp33bb6	519	15	influenza	influenza	NN
cord-018265-twp33bb6	519	16	whole	whole	JJ
cord-018265-twp33bb6	519	17	virus	virus	NN
cord-018265-twp33bb6	519	18	vaccine	vaccine	NN
cord-018265-twp33bb6	519	19	Influvac	Influvac	NNP
cord-018265-twp33bb6	519	20	:	:	:
cord-018265-twp33bb6	519	21	a	a	DT
cord-018265-twp33bb6	519	22	safe	safe	JJ
cord-018265-twp33bb6	519	23	Madin	Madin	NNP
cord-018265-twp33bb6	519	24	Darby	Darby	NNP
cord-018265-twp33bb6	519	25	Canine	canine	JJ
cord-018265-twp33bb6	519	26	Kidney	kidney	NN
cord-018265-twp33bb6	519	27	(	(	-LRB-
cord-018265-twp33bb6	519	28	MDCK	MDCK	NNP
cord-018265-twp33bb6	519	29	)	)	-RRB-
cord-018265-twp33bb6	519	30	cell	cell	NN
cord-018265-twp33bb6	519	31	culture	culture	NN
cord-018265-twp33bb6	519	32	-	-	HYPH
cord-018265-twp33bb6	519	33	based	base	VBN
cord-018265-twp33bb6	519	34	influenza	influenza	NN
cord-018265-twp33bb6	519	35	vaccine	vaccine	NN
cord-018265-twp33bb6	519	36	Structure	Structure	NNP
cord-018265-twp33bb6	519	37	of	of	IN
cord-018265-twp33bb6	519	38	influenza	influenza	NN
cord-018265-twp33bb6	519	39	haemagglutinin	haemagglutinin	NNP
cord-018265-twp33bb6	519	40	at	at	IN
cord-018265-twp33bb6	519	41	the	the	DT
cord-018265-twp33bb6	519	42	pH	pH	NNP
cord-018265-twp33bb6	519	43	of	of	IN
cord-018265-twp33bb6	519	44	membrane	membrane	NN
cord-018265-twp33bb6	519	45	fusion	fusion	NN
cord-018265-twp33bb6	519	46	Influenza	Influenza	NNP
cord-018265-twp33bb6	519	47	vaccine	vaccine	NN
cord-018265-twp33bb6	519	48	-	-	HYPH
cord-018265-twp33bb6	519	49	live	live	JJ
cord-018265-twp33bb6	519	50	Influenza	Influenza	NNP
cord-018265-twp33bb6	519	51	virus	virus	NN
cord-018265-twp33bb6	519	52	:	:	:
cord-018265-twp33bb6	519	53	immunity	immunity	NN
cord-018265-twp33bb6	519	54	and	and	CC
cord-018265-twp33bb6	519	55	vaccination	vaccination	NN
cord-018265-twp33bb6	519	56	strategies	strategy	NNS
cord-018265-twp33bb6	519	57	.	.	.
cord-018265-twp33bb6	520	1	Comparison	comparison	NN
cord-018265-twp33bb6	520	2	of	of	IN
cord-018265-twp33bb6	520	3	the	the	DT
cord-018265-twp33bb6	520	4	immune	immune	JJ
cord-018265-twp33bb6	520	5	response	response	NN
cord-018265-twp33bb6	520	6	to	to	IN
cord-018265-twp33bb6	520	7	inactivated	inactivate	VBN
cord-018265-twp33bb6	520	8	and	and	CC
cord-018265-twp33bb6	520	9	live	live	VB
cord-018265-twp33bb6	520	10	,	,	,
cord-018265-twp33bb6	520	11	attenuated	attenuated	JJ
cord-018265-twp33bb6	520	12	influenza	influenza	NN
cord-018265-twp33bb6	520	13	vaccines	vaccine	VBZ
cord-018265-twp33bb6	520	14	Current	current	JJ
cord-018265-twp33bb6	520	15	status	status	NN
cord-018265-twp33bb6	520	16	of	of	IN
cord-018265-twp33bb6	520	17	live	live	JJ
cord-018265-twp33bb6	520	18	attenuated	attenuated	JJ
cord-018265-twp33bb6	520	19	influenza	influenza	NN
cord-018265-twp33bb6	520	20	virus	virus	NN
cord-018265-twp33bb6	520	21	vaccine	vaccine	NN
cord-018265-twp33bb6	520	22	in	in	IN
cord-018265-twp33bb6	520	23	the	the	DT
cord-018265-twp33bb6	520	24	US	US	NNP
cord-018265-twp33bb6	520	25	Evaluation	Evaluation	NNP
cord-018265-twp33bb6	520	26	of	of	IN
cord-018265-twp33bb6	520	27	trivalent	trivalent	JJ
cord-018265-twp33bb6	520	28	,	,	,
cord-018265-twp33bb6	520	29	live	live	JJ
cord-018265-twp33bb6	520	30	,	,	,
cord-018265-twp33bb6	520	31	cold	cold	RB
cord-018265-twp33bb6	520	32	-	-	HYPH
cord-018265-twp33bb6	520	33	adapted	adapt	VBN
cord-018265-twp33bb6	520	34	(	(	-LRB-
cord-018265-twp33bb6	520	35	CAIV	CAIV	NNP
cord-018265-twp33bb6	520	36	-	-	HYPH
cord-018265-twp33bb6	520	37	T	T	NNP
cord-018265-twp33bb6	520	38	)	)	-RRB-
cord-018265-twp33bb6	520	39	and	and	CC
cord-018265-twp33bb6	520	40	inactivated	inactivate	VBN
cord-018265-twp33bb6	520	41	(	(	-LRB-
cord-018265-twp33bb6	520	42	TIV	TIV	NNP
cord-018265-twp33bb6	520	43	)	)	-RRB-
cord-018265-twp33bb6	520	44	influenza	influenza	NN
cord-018265-twp33bb6	520	45	vaccines	vaccine	NNS
cord-018265-twp33bb6	520	46	in	in	IN
cord-018265-twp33bb6	520	47	prevention	prevention	NN
cord-018265-twp33bb6	520	48	of	of	IN
cord-018265-twp33bb6	520	49	virus	virus	NN
cord-018265-twp33bb6	520	50	infection	infection	NN
cord-018265-twp33bb6	520	51	and	and	CC
cord-018265-twp33bb6	520	52	illness	illness	NN
cord-018265-twp33bb6	520	53	following	follow	VBG
cord-018265-twp33bb6	520	54	challenge	challenge	NN
cord-018265-twp33bb6	520	55	of	of	IN
cord-018265-twp33bb6	520	56	adults	adult	NNS
cord-018265-twp33bb6	520	57	with	with	IN
cord-018265-twp33bb6	520	58	wild	wild	JJ
cord-018265-twp33bb6	520	59	-	-	HYPH
cord-018265-twp33bb6	520	60	type	type	NN
cord-018265-twp33bb6	520	61	influenza	influenza	NN
cord-018265-twp33bb6	520	62	A	a	NN
cord-018265-twp33bb6	520	63	(	(	-LRB-
cord-018265-twp33bb6	520	64	H1N1	H1N1	NNP
cord-018265-twp33bb6	520	65	)	)	-RRB-
cord-018265-twp33bb6	520	66	,	,	,
cord-018265-twp33bb6	520	67	A	a	DT
cord-018265-twp33bb6	520	68	(	(	-LRB-
cord-018265-twp33bb6	520	69	H3N2	H3N2	NNP
cord-018265-twp33bb6	520	70	)	)	-RRB-
cord-018265-twp33bb6	520	71	,	,	,
cord-018265-twp33bb6	520	72	and	and	CC
cord-018265-twp33bb6	520	73	B	b	NN
cord-018265-twp33bb6	520	74	viruses	virus	NNS
cord-018265-twp33bb6	520	75	Safety	Safety	NNP
cord-018265-twp33bb6	520	76	,	,	,
cord-018265-twp33bb6	520	77	efficacy	efficacy	NN
cord-018265-twp33bb6	520	78	,	,	,
cord-018265-twp33bb6	520	79	and	and	CC
cord-018265-twp33bb6	520	80	effectiveness	effectiveness	NN
cord-018265-twp33bb6	520	81	of	of	IN
cord-018265-twp33bb6	520	82	live	live	JJ
cord-018265-twp33bb6	520	83	,	,	,
cord-018265-twp33bb6	520	84	attenuated	attenuated	JJ
cord-018265-twp33bb6	520	85	,	,	,
cord-018265-twp33bb6	520	86	cold	cold	RB
cord-018265-twp33bb6	520	87	-	-	HYPH
cord-018265-twp33bb6	520	88	adapted	adapt	VBN
cord-018265-twp33bb6	520	89	influenza	influenza	NN
cord-018265-twp33bb6	520	90	vaccine	vaccine	NN
cord-018265-twp33bb6	520	91	in	in	IN
cord-018265-twp33bb6	520	92	an	an	DT
cord-018265-twp33bb6	520	93	indicated	indicate	VBN
cord-018265-twp33bb6	520	94	population	population	NN
cord-018265-twp33bb6	520	95	aged	age	VBN
cord-018265-twp33bb6	521	1	5	5	LS
cord-018265-twp33bb6	521	2	-	-	SYM
cord-018265-twp33bb6	521	3	49	49	CD
cord-018265-twp33bb6	521	4	years	year	NNS
cord-018265-twp33bb6	521	5	Correlates	correlate	NNS
cord-018265-twp33bb6	521	6	of	of	IN
cord-018265-twp33bb6	521	7	ratory	ratory	JJ
cord-018265-twp33bb6	521	8	syncytial	syncytial	JJ
cord-018265-twp33bb6	521	9	virus	virus	NN
cord-018265-twp33bb6	521	10	purified	purify	VBN
cord-018265-twp33bb6	521	11	fusion	fusion	NN
cord-018265-twp33bb6	521	12	protein-2	protein-2	VBZ
cord-018265-twp33bb6	521	13	vaccine	vaccine	NN
cord-018265-twp33bb6	521	14	in	in	IN
cord-018265-twp33bb6	521	15	pregnant	pregnant	JJ
cord-018265-twp33bb6	521	16	women	woman	NNS
cord-018265-twp33bb6	521	17	Sequential	sequential	JJ
cord-018265-twp33bb6	521	18	annual	annual	JJ
cord-018265-twp33bb6	521	19	administration	administration	NN
cord-018265-twp33bb6	521	20	of	of	IN
cord-018265-twp33bb6	521	21	purified	purify	VBN
cord-018265-twp33bb6	521	22	fusion	fusion	NN
cord-018265-twp33bb6	521	23	protein	protein	NN
cord-018265-twp33bb6	521	24	vaccine	vaccine	NN
cord-018265-twp33bb6	521	25	against	against	IN
cord-018265-twp33bb6	521	26	respiratory	respiratory	JJ
cord-018265-twp33bb6	521	27	syncytial	syncytial	JJ
cord-018265-twp33bb6	521	28	virus	virus	NN
cord-018265-twp33bb6	521	29	in	in	IN
cord-018265-twp33bb6	521	30	children	child	NNS
cord-018265-twp33bb6	521	31	with	with	IN
cord-018265-twp33bb6	521	32	cystic	cystic	JJ
cord-018265-twp33bb6	521	33	fibrosis	fibrosis	NN
cord-018265-twp33bb6	522	1	Enhanced	enhanced	JJ
cord-018265-twp33bb6	522	2	pulmonary	pulmonary	JJ
cord-018265-twp33bb6	522	3	immunopathology	immunopathology	NN
cord-018265-twp33bb6	522	4	following	follow	VBG
cord-018265-twp33bb6	522	5	neonatal	neonatal	JJ
cord-018265-twp33bb6	522	6	priming	priming	NN
cord-018265-twp33bb6	522	7	with	with	IN
cord-018265-twp33bb6	522	8	formalin	formalin	NN
cord-018265-twp33bb6	522	9	-	-	HYPH
cord-018265-twp33bb6	522	10	inactivated	inactivate	VBN
cord-018265-twp33bb6	522	11	respiratory	respiratory	JJ
cord-018265-twp33bb6	522	12	syncytial	syncytial	JJ
cord-018265-twp33bb6	522	13	virus	virus	NN
cord-018265-twp33bb6	522	14	but	but	CC
cord-018265-twp33bb6	522	15	not	not	RB
cord-018265-twp33bb6	522	16	with	with	IN
cord-018265-twp33bb6	522	17	the	the	DT
cord-018265-twp33bb6	522	18	BBG2NA	BBG2NA	NNP
cord-018265-twp33bb6	522	19	vaccine	vaccine	NN
cord-018265-twp33bb6	522	20	candidate	candidate	NN
cord-018265-twp33bb6	522	21	Safety	safety	NN
cord-018265-twp33bb6	522	22	and	and	CC
cord-018265-twp33bb6	522	23	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	522	24	of	of	IN
cord-018265-twp33bb6	522	25	a	a	DT
cord-018265-twp33bb6	522	26	novel	novel	JJ
cord-018265-twp33bb6	522	27	recombinant	recombinant	JJ
cord-018265-twp33bb6	522	28	subunit	subunit	NN
cord-018265-twp33bb6	522	29	respiratory	respiratory	JJ
cord-018265-twp33bb6	522	30	syncytial	syncytial	JJ
cord-018265-twp33bb6	522	31	virus	virus	NN
cord-018265-twp33bb6	522	32	vaccine	vaccine	NN
cord-018265-twp33bb6	522	33	(	(	-LRB-
cord-018265-twp33bb6	522	34	BBG2Na	BBG2Na	NNP
cord-018265-twp33bb6	522	35	)	)	-RRB-
cord-018265-twp33bb6	522	36	in	in	IN
cord-018265-twp33bb6	522	37	healthy	healthy	JJ
cord-018265-twp33bb6	522	38	young	young	JJ
cord-018265-twp33bb6	522	39	adults	adult	NNS
cord-018265-twp33bb6	523	1	The	the	DT
cord-018265-twp33bb6	523	2	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	523	3	,	,	,
cord-018265-twp33bb6	523	4	protective	protective	JJ
cord-018265-twp33bb6	523	5	efficacy	efficacy	NN
cord-018265-twp33bb6	523	6	and	and	CC
cord-018265-twp33bb6	523	7	safety	safety	NN
cord-018265-twp33bb6	523	8	of	of	IN
cord-018265-twp33bb6	523	9	BBG2Na	BBG2Na	NNP
cord-018265-twp33bb6	523	10	,	,	,
cord-018265-twp33bb6	523	11	a	a	DT
cord-018265-twp33bb6	523	12	subunit	subunit	NN
cord-018265-twp33bb6	523	13	respiratory	respiratory	JJ
cord-018265-twp33bb6	523	14	syncytial	syncytial	JJ
cord-018265-twp33bb6	523	15	virus	virus	NN
cord-018265-twp33bb6	523	16	(	(	-LRB-
cord-018265-twp33bb6	523	17	RSV	RSV	NNP
cord-018265-twp33bb6	523	18	)	)	-RRB-
cord-018265-twp33bb6	523	19	vaccine	vaccine	NN
cord-018265-twp33bb6	523	20	candidate	candidate	NN
cord-018265-twp33bb6	523	21	,	,	,
cord-018265-twp33bb6	523	22	against	against	IN
cord-018265-twp33bb6	523	23	RSV	RSV	NNP
cord-018265-twp33bb6	523	24	-	-	HYPH
cord-018265-twp33bb6	523	25	B	B	NNP
cord-018265-twp33bb6	523	26	Evaluation	Evaluation	NNP
cord-018265-twp33bb6	523	27	of	of	IN
cord-018265-twp33bb6	523	28	a	a	DT
cord-018265-twp33bb6	523	29	live	live	JJ
cord-018265-twp33bb6	523	30	,	,	,
cord-018265-twp33bb6	523	31	cold	cold	JJ
cord-018265-twp33bb6	523	32	-	-	HYPH
cord-018265-twp33bb6	523	33	passaged	passaged	JJ
cord-018265-twp33bb6	523	34	,	,	,
cord-018265-twp33bb6	523	35	temperature	temperature	NN
cord-018265-twp33bb6	523	36	-	-	HYPH
cord-018265-twp33bb6	523	37	sensitive	sensitive	JJ
cord-018265-twp33bb6	523	38	,	,	,
cord-018265-twp33bb6	523	39	respiratory	respiratory	JJ
cord-018265-twp33bb6	523	40	syncytial	syncytial	JJ
cord-018265-twp33bb6	523	41	virus	virus	NN
cord-018265-twp33bb6	523	42	vaccine	vaccine	NN
cord-018265-twp33bb6	523	43	candidate	candidate	NN
cord-018265-twp33bb6	523	44	in	in	IN
cord-018265-twp33bb6	523	45	infancy	infancy	NN
cord-018265-twp33bb6	524	1	Recombinant	recombinant	JJ
cord-018265-twp33bb6	524	2	bovine	bovine	JJ
cord-018265-twp33bb6	524	3	/	/	SYM
cord-018265-twp33bb6	524	4	human	human	JJ
cord-018265-twp33bb6	524	5	parainfluenza	parainfluenza	NNP
cord-018265-twp33bb6	524	6	virus	virus	NNP
cord-018265-twp33bb6	524	7	type	type	NNP
cord-018265-twp33bb6	524	8	3	3	CD
cord-018265-twp33bb6	525	1	(	(	-LRB-
cord-018265-twp33bb6	525	2	B	b	NN
cord-018265-twp33bb6	525	3	/	/	SYM
cord-018265-twp33bb6	525	4	HPIV3	HPIV3	NNP
cord-018265-twp33bb6	525	5	)	)	-RRB-
cord-018265-twp33bb6	525	6	expressing	express	VBG
cord-018265-twp33bb6	525	7	the	the	DT
cord-018265-twp33bb6	525	8	respiratory	respiratory	JJ
cord-018265-twp33bb6	525	9	syncytial	syncytial	JJ
cord-018265-twp33bb6	525	10	virus	virus	NN
cord-018265-twp33bb6	525	11	(	(	-LRB-
cord-018265-twp33bb6	525	12	RSV	RSV	NNP
cord-018265-twp33bb6	525	13	)	)	-RRB-
cord-018265-twp33bb6	525	14	G	G	NNP
cord-018265-twp33bb6	525	15	and	and	CC
cord-018265-twp33bb6	525	16	F	f	NN
cord-018265-twp33bb6	525	17	proteins	protein	NNS
cord-018265-twp33bb6	525	18	can	can	MD
cord-018265-twp33bb6	525	19	be	be	VB
cord-018265-twp33bb6	525	20	used	use	VBN
cord-018265-twp33bb6	525	21	to	to	TO
cord-018265-twp33bb6	525	22	achieve	achieve	VB
cord-018265-twp33bb6	525	23	simultaneous	simultaneous	JJ
cord-018265-twp33bb6	525	24	mucosal	mucosal	JJ
cord-018265-twp33bb6	525	25	immunization	immunization	NN
cord-018265-twp33bb6	525	26	against	against	IN
cord-018265-twp33bb6	525	27	RSV	RSV	NNP
cord-018265-twp33bb6	525	28	and	and	CC
cord-018265-twp33bb6	525	29	HPIV3	HPIV3	NNP
cord-018265-twp33bb6	526	1	Parainfluenza	Parainfluenza	NNP
cord-018265-twp33bb6	526	2	virus	virus	NN
cord-018265-twp33bb6	526	3	type	type	NN
cord-018265-twp33bb6	526	4	3	3	CD
cord-018265-twp33bb6	526	5	expressing	express	VBG
cord-018265-twp33bb6	527	1	the	the	DT
cord-018265-twp33bb6	527	2	native	native	JJ
cord-018265-twp33bb6	527	3	or	or	CC
cord-018265-twp33bb6	527	4	soluble	soluble	JJ
cord-018265-twp33bb6	527	5	fusion	fusion	NN
cord-018265-twp33bb6	527	6	(	(	-LRB-
cord-018265-twp33bb6	527	7	F	F	NNP
cord-018265-twp33bb6	527	8	)	)	-RRB-
cord-018265-twp33bb6	527	9	Protein	Protein	NNP
cord-018265-twp33bb6	527	10	of	of	IN
cord-018265-twp33bb6	527	11	Respiratory	Respiratory	NNP
cord-018265-twp33bb6	527	12	Syncytial	Syncytial	NNP
cord-018265-twp33bb6	527	13	Virus	virus	NN
cord-018265-twp33bb6	527	14	(	(	-LRB-
cord-018265-twp33bb6	527	15	RSV	RSV	NNP
cord-018265-twp33bb6	527	16	)	)	-RRB-
cord-018265-twp33bb6	527	17	confers	confer	VBZ
cord-018265-twp33bb6	527	18	protection	protection	NN
cord-018265-twp33bb6	527	19	from	from	IN
cord-018265-twp33bb6	527	20	RSV	RSV	NNP
cord-018265-twp33bb6	527	21	infection	infection	NN
cord-018265-twp33bb6	527	22	in	in	IN
cord-018265-twp33bb6	527	23	African	african	JJ
cord-018265-twp33bb6	527	24	green	green	JJ
cord-018265-twp33bb6	527	25	monkeys	monkey	NNS
cord-018265-twp33bb6	528	1	Severe	severe	JJ
cord-018265-twp33bb6	528	2	acute	acute	JJ
cord-018265-twp33bb6	528	3	respiratory	respiratory	JJ
cord-018265-twp33bb6	528	4	syndrome	syndrome	NN
cord-018265-twp33bb6	528	5	SARS	SARS	NNP
cord-018265-twp33bb6	528	6	-	-	HYPH
cord-018265-twp33bb6	528	7	associated	associate	VBN
cord-018265-twp33bb6	528	8	coronavirus	coronavirus	NN
cord-018265-twp33bb6	529	1	Angiotensin	angiotensin	NN
cord-018265-twp33bb6	529	2	-	-	HYPH
cord-018265-twp33bb6	529	3	converting	convert	VBG
cord-018265-twp33bb6	529	4	enzyme	enzyme	NN
cord-018265-twp33bb6	529	5	2	2	CD
cord-018265-twp33bb6	529	6	is	be	VBZ
cord-018265-twp33bb6	529	7	a	a	DT
cord-018265-twp33bb6	529	8	functional	functional	JJ
cord-018265-twp33bb6	529	9	receptor	receptor	NN
cord-018265-twp33bb6	529	10	for	for	IN
cord-018265-twp33bb6	529	11	the	the	DT
cord-018265-twp33bb6	529	12	SARS	SARS	NNP
cord-018265-twp33bb6	529	13	coronavirus	coronavirus	NN
cord-018265-twp33bb6	530	1	A	a	DT
cord-018265-twp33bb6	530	2	193-amino	193-amino	CD
cord-018265-twp33bb6	530	3	acid	acid	NN
cord-018265-twp33bb6	530	4	fragment	fragment	NN
cord-018265-twp33bb6	530	5	of	of	IN
cord-018265-twp33bb6	530	6	the	the	DT
cord-018265-twp33bb6	530	7	SARS	SARS	NNP
cord-018265-twp33bb6	530	8	coronavirus	coronavirus	NN
cord-018265-twp33bb6	530	9	S	S	NNP
cord-018265-twp33bb6	530	10	protein	protein	NN
cord-018265-twp33bb6	530	11	efficiently	efficiently	RB
cord-018265-twp33bb6	530	12	binds	bind	VBZ
cord-018265-twp33bb6	530	13	angiotensin	angiotensin	NN
cord-018265-twp33bb6	530	14	-	-	HYPH
cord-018265-twp33bb6	530	15	converting	convert	VBG
cord-018265-twp33bb6	530	16	enzyme	enzyme	NN
cord-018265-twp33bb6	530	17	2	2	CD
cord-018265-twp33bb6	530	18	A	a	DT
cord-018265-twp33bb6	530	19	DNA	dna	NN
cord-018265-twp33bb6	530	20	vaccine	vaccine	NN
cord-018265-twp33bb6	530	21	induces	induce	VBZ
cord-018265-twp33bb6	530	22	SARS	SARS	NNP
cord-018265-twp33bb6	530	23	coronavirus	coronavirus	NN
cord-018265-twp33bb6	530	24	neutralization	neutralization	NN
cord-018265-twp33bb6	530	25	and	and	CC
cord-018265-twp33bb6	530	26	protective	protective	JJ
cord-018265-twp33bb6	530	27	immunity	immunity	NN
cord-018265-twp33bb6	530	28	in	in	IN
cord-018265-twp33bb6	530	29	mice	mouse	NNS
cord-018265-twp33bb6	530	30	Identification	identification	NN
cord-018265-twp33bb6	530	31	of	of	IN
cord-018265-twp33bb6	530	32	two	two	CD
cord-018265-twp33bb6	530	33	neutralizing	neutralize	VBG
cord-018265-twp33bb6	530	34	regions	region	NNS
cord-018265-twp33bb6	530	35	on	on	IN
cord-018265-twp33bb6	530	36	the	the	DT
cord-018265-twp33bb6	530	37	severe	severe	JJ
cord-018265-twp33bb6	530	38	acute	acute	JJ
cord-018265-twp33bb6	530	39	respiratory	respiratory	JJ
cord-018265-twp33bb6	530	40	syndrome	syndrome	NN
cord-018265-twp33bb6	530	41	coronavirus	coronavirus	NN
cord-018265-twp33bb6	530	42	spike	spike	NN
cord-018265-twp33bb6	530	43	glycoprotein	glycoprotein	NN
cord-018265-twp33bb6	530	44	produced	produce	VBN
cord-018265-twp33bb6	530	45	from	from	IN
cord-018265-twp33bb6	530	46	the	the	DT
cord-018265-twp33bb6	530	47	mammalian	mammalian	JJ
cord-018265-twp33bb6	530	48	expression	expression	NN
cord-018265-twp33bb6	530	49	system	system	NN
cord-018265-twp33bb6	530	50	Mucosal	Mucosal	NNP
cord-018265-twp33bb6	530	51	immunisation	immunisation	NN
cord-018265-twp33bb6	530	52	of	of	IN
cord-018265-twp33bb6	530	53	African	african	JJ
cord-018265-twp33bb6	530	54	green	green	JJ
cord-018265-twp33bb6	530	55	monkeys	monkey	NNS
cord-018265-twp33bb6	530	56	(	(	-LRB-
cord-018265-twp33bb6	530	57	Cercopithecus	Cercopithecus	NNP
cord-018265-twp33bb6	530	58	aethiops	aethiop	NNS
cord-018265-twp33bb6	530	59	)	)	-RRB-
cord-018265-twp33bb6	530	60	with	with	IN
cord-018265-twp33bb6	530	61	an	an	DT
cord-018265-twp33bb6	530	62	attenuated	attenuated	JJ
cord-018265-twp33bb6	530	63	parainfluenza	parainfluenza	NNP
cord-018265-twp33bb6	530	64	virus	virus	NN
cord-018265-twp33bb6	530	65	expressing	express	VBG
cord-018265-twp33bb6	530	66	the	the	DT
cord-018265-twp33bb6	530	67	SARS	SARS	NNP
cord-018265-twp33bb6	530	68	coronavirus	coronavirus	NN
cord-018265-twp33bb6	530	69	spike	spike	NN
cord-018265-twp33bb6	530	70	protein	protein	NN
cord-018265-twp33bb6	530	71	for	for	IN
cord-018265-twp33bb6	530	72	the	the	DT
cord-018265-twp33bb6	530	73	prevention	prevention	NN
cord-018265-twp33bb6	530	74	of	of	IN
cord-018265-twp33bb6	530	75	SARS	SARS	NNP
cord-018265-twp33bb6	530	76	Immunization	Immunization	NNP
cord-018265-twp33bb6	530	77	with	with	IN
cord-018265-twp33bb6	530	78	modified	modify	VBN
cord-018265-twp33bb6	530	79	vaccinia	vaccinia	NN
cord-018265-twp33bb6	530	80	virus	virus	NN
cord-018265-twp33bb6	530	81	Ankara	Ankara	NNP
cord-018265-twp33bb6	530	82	-	-	HYPH
cord-018265-twp33bb6	530	83	based	base	VBN
cord-018265-twp33bb6	530	84	recombinant	recombinant	JJ
cord-018265-twp33bb6	530	85	vaccine	vaccine	NN
cord-018265-twp33bb6	530	86	against	against	IN
cord-018265-twp33bb6	530	87	severe	severe	JJ
cord-018265-twp33bb6	530	88	acute	acute	JJ
cord-018265-twp33bb6	530	89	respiratory	respiratory	JJ
cord-018265-twp33bb6	530	90	syndrome	syndrome	NN
cord-018265-twp33bb6	530	91	is	be	VBZ
cord-018265-twp33bb6	530	92	associated	associate	VBN
cord-018265-twp33bb6	530	93	with	with	IN
cord-018265-twp33bb6	530	94	enhanced	enhance	VBN
cord-018265-twp33bb6	530	95	hepatitis	hepatitis	NN
cord-018265-twp33bb6	530	96	in	in	IN
cord-018265-twp33bb6	530	97	ferrets	ferret	NNS
cord-018265-twp33bb6	530	98	Interaction	Interaction	NNP
cord-018265-twp33bb6	530	99	between	between	IN
cord-018265-twp33bb6	530	100	heptad	heptad	NN
cord-018265-twp33bb6	530	101	repeat	repeat	NN
cord-018265-twp33bb6	530	102	1	1	CD
cord-018265-twp33bb6	530	103	and	and	CC
cord-018265-twp33bb6	530	104	2	2	CD
cord-018265-twp33bb6	530	105	regions	region	NNS
cord-018265-twp33bb6	530	106	in	in	IN
cord-018265-twp33bb6	530	107	spike	spike	NN
cord-018265-twp33bb6	530	108	protein	protein	NN
cord-018265-twp33bb6	530	109	of	of	IN
cord-018265-twp33bb6	530	110	SARS	SARS	NNP
cord-018265-twp33bb6	530	111	-	-	HYPH
cord-018265-twp33bb6	530	112	associated	associate	VBN
cord-018265-twp33bb6	530	113	coronavirus	coronavirus	NN
cord-018265-twp33bb6	530	114	:	:	:
cord-018265-twp33bb6	530	115	implications	implication	NNS
cord-018265-twp33bb6	530	116	for	for	IN
cord-018265-twp33bb6	530	117	virus	virus	NN
cord-018265-twp33bb6	530	118	fusogenic	fusogenic	NNP
cord-018265-twp33bb6	530	119	mechanism	mechanism	NN
cord-018265-twp33bb6	530	120	and	and	CC
cord-018265-twp33bb6	530	121	identification	identification	NN
cord-018265-twp33bb6	530	122	of	of	IN
cord-018265-twp33bb6	530	123	fusion	fusion	NN
cord-018265-twp33bb6	530	124	inhibitors	inhibitor	NNS
cord-018265-twp33bb6	530	125	Evasion	evasion	NN
cord-018265-twp33bb6	530	126	of	of	IN
cord-018265-twp33bb6	530	127	antibody	antibody	NN
cord-018265-twp33bb6	530	128	neutralization	neutralization	NN
cord-018265-twp33bb6	530	129	in	in	IN
cord-018265-twp33bb6	530	130	emerging	emerge	VBG
cord-018265-twp33bb6	530	131	severe	severe	JJ
cord-018265-twp33bb6	530	132	acute	acute	JJ
cord-018265-twp33bb6	530	133	respiratory	respiratory	JJ
cord-018265-twp33bb6	530	134	syndrome	syndrome	NN
cord-018265-twp33bb6	530	135	coronaviruses	coronaviruse	NNS
cord-018265-twp33bb6	531	1	Induction	Induction	NNP
cord-018265-twp33bb6	531	2	of	of	IN
cord-018265-twp33bb6	531	3	SARS	SARS	NNP
cord-018265-twp33bb6	531	4	-	-	HYPH
cord-018265-twp33bb6	531	5	nucleoprotein	nucleoprotein	NNP
cord-018265-twp33bb6	531	6	-	-	HYPH
cord-018265-twp33bb6	531	7	specific	specific	JJ
cord-018265-twp33bb6	531	8	immune	immune	JJ
cord-018265-twp33bb6	531	9	response	response	NN
cord-018265-twp33bb6	531	10	by	by	IN
cord-018265-twp33bb6	531	11	use	use	NN
cord-018265-twp33bb6	531	12	of	of	IN
cord-018265-twp33bb6	531	13	DNA	dna	NN
cord-018265-twp33bb6	531	14	vaccine	vaccine	NN
cord-018265-twp33bb6	531	15	Contributions	contribution	NNS
cord-018265-twp33bb6	531	16	of	of	IN
cord-018265-twp33bb6	531	17	the	the	DT
cord-018265-twp33bb6	531	18	structural	structural	JJ
cord-018265-twp33bb6	531	19	proteins	protein	NNS
cord-018265-twp33bb6	531	20	of	of	IN
cord-018265-twp33bb6	531	21	severe	severe	JJ
cord-018265-twp33bb6	531	22	acute	acute	JJ
cord-018265-twp33bb6	531	23	respiratory	respiratory	JJ
cord-018265-twp33bb6	531	24	syndrome	syndrome	NN
cord-018265-twp33bb6	531	25	coronavirus	coronavirus	NN
cord-018265-twp33bb6	531	26	to	to	IN
cord-018265-twp33bb6	531	27	protective	protective	JJ
cord-018265-twp33bb6	531	28	immunity	immunity	NN
cord-018265-twp33bb6	531	29	Prevention	Prevention	NNP
cord-018265-twp33bb6	531	30	of	of	IN
cord-018265-twp33bb6	531	31	adenoviral	adenoviral	JJ
cord-018265-twp33bb6	531	32	acute	acute	JJ
cord-018265-twp33bb6	531	33	respiratory	respiratory	JJ
cord-018265-twp33bb6	531	34	disease	disease	NN
cord-018265-twp33bb6	531	35	in	in	IN
cord-018265-twp33bb6	531	36	Army	Army	NNP
cord-018265-twp33bb6	531	37	recruits	recruit	NNS
cord-018265-twp33bb6	531	38	:	:	:
cord-018265-twp33bb6	531	39	cost	cost	NN
cord-018265-twp33bb6	531	40	-	-	HYPH
cord-018265-twp33bb6	531	41	effectiveness	effectiveness	NN
cord-018265-twp33bb6	531	42	of	of	IN
cord-018265-twp33bb6	531	43	a	a	DT
cord-018265-twp33bb6	531	44	military	military	JJ
cord-018265-twp33bb6	531	45	vaccination	vaccination	NN
cord-018265-twp33bb6	531	46	policy	policy	NN
cord-018265-twp33bb6	531	47	Current	current	JJ
cord-018265-twp33bb6	531	48	research	research	NN
cord-018265-twp33bb6	531	49	on	on	IN
cord-018265-twp33bb6	531	50	respiratory	respiratory	JJ
cord-018265-twp33bb6	531	51	viral	viral	JJ
cord-018265-twp33bb6	531	52	infections	infection	NNS
cord-018265-twp33bb6	531	53	:	:	:
cord-018265-twp33bb6	532	1	Third	Third	NNP
cord-018265-twp33bb6	532	2	International	International	NNP
cord-018265-twp33bb6	532	3	Symposium	Symposium	NNP
cord-018265-twp33bb6	532	4	Respiratory	respiratory	JJ
cord-018265-twp33bb6	532	5	bacterial	bacterial	JJ
cord-018265-twp33bb6	532	6	vaccines	vaccine	NNS
cord-018265-twp33bb6	532	7	Pneumococcal	Pneumococcal	NNP
cord-018265-twp33bb6	532	8	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	532	9	Randomised	randomised	JJ
cord-018265-twp33bb6	532	10	trial	trial	NN
cord-018265-twp33bb6	532	11	of	of	IN
cord-018265-twp33bb6	532	12	23-valent	23-valent	CD
cord-018265-twp33bb6	532	13	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	532	14	capsular	capsular	NN
cord-018265-twp33bb6	532	15	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	532	16	vaccine	vaccine	NN
cord-018265-twp33bb6	532	17	in	in	IN
cord-018265-twp33bb6	532	18	prevention	prevention	NN
cord-018265-twp33bb6	532	19	of	of	IN
cord-018265-twp33bb6	532	20	pneumonia	pneumonia	NN
cord-018265-twp33bb6	532	21	in	in	IN
cord-018265-twp33bb6	532	22	middle	middle	NN
cord-018265-twp33bb6	532	23	-	-	HYPH
cord-018265-twp33bb6	532	24	aged	aged	JJ
cord-018265-twp33bb6	532	25	and	and	CC
cord-018265-twp33bb6	532	26	elderly	elderly	JJ
cord-018265-twp33bb6	532	27	people	people	NNS
cord-018265-twp33bb6	532	28	.	.	.
cord-018265-twp33bb6	533	1	Swedish	Swedish	NNP
cord-018265-twp33bb6	533	2	Pneumococcal	Pneumococcal	NNP
cord-018265-twp33bb6	533	3	Vaccination	Vaccination	NNP
cord-018265-twp33bb6	533	4	Study	Study	NNP
cord-018265-twp33bb6	533	5	Group	Group	NNP
cord-018265-twp33bb6	533	6	Maternal	maternal	JJ
cord-018265-twp33bb6	533	7	immunization	immunization	NN
cord-018265-twp33bb6	533	8	with	with	IN
cord-018265-twp33bb6	533	9	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	533	10	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	533	11	vaccine	vaccine	NN
cord-018265-twp33bb6	533	12	in	in	IN
cord-018265-twp33bb6	533	13	the	the	DT
cord-018265-twp33bb6	533	14	third	third	JJ
cord-018265-twp33bb6	533	15	trimester	trimester	NN
cord-018265-twp33bb6	533	16	of	of	IN
cord-018265-twp33bb6	534	1	gestation	gestation	NN
cord-018265-twp33bb6	534	2	A	a	DT
cord-018265-twp33bb6	534	3	trial	trial	NN
cord-018265-twp33bb6	534	4	of	of	IN
cord-018265-twp33bb6	534	5	a	a	DT
cord-018265-twp33bb6	534	6	9-valent	9-valent	CD
cord-018265-twp33bb6	534	7	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	534	8	conjugate	conjugate	NN
cord-018265-twp33bb6	534	9	vaccine	vaccine	NN
cord-018265-twp33bb6	534	10	in	in	IN
cord-018265-twp33bb6	534	11	children	child	NNS
cord-018265-twp33bb6	534	12	with	with	IN
cord-018265-twp33bb6	534	13	and	and	CC
cord-018265-twp33bb6	534	14	those	those	DT
cord-018265-twp33bb6	534	15	without	without	IN
cord-018265-twp33bb6	534	16	HIV	HIV	NNP
cord-018265-twp33bb6	534	17	infection	infection	NN
cord-018265-twp33bb6	534	18	Impact	Impact	NNP
cord-018265-twp33bb6	534	19	of	of	IN
cord-018265-twp33bb6	534	20	the	the	DT
cord-018265-twp33bb6	534	21	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	534	22	conjugate	conjugate	NN
cord-018265-twp33bb6	534	23	vaccine	vaccine	NN
cord-018265-twp33bb6	534	24	on	on	IN
cord-018265-twp33bb6	534	25	otitis	otitis	NN
cord-018265-twp33bb6	534	26	media	medium	NNS
cord-018265-twp33bb6	534	27	Pneumococcal	Pneumococcal	NNP
cord-018265-twp33bb6	534	28	conjugate	conjugate	JJ
cord-018265-twp33bb6	534	29	vaccine	vaccine	NN
cord-018265-twp33bb6	534	30	Decline	decline	VB
cord-018265-twp33bb6	534	31	in	in	IN
cord-018265-twp33bb6	534	32	invasive	invasive	JJ
cord-018265-twp33bb6	534	33	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	534	34	disease	disease	NN
cord-018265-twp33bb6	534	35	after	after	IN
cord-018265-twp33bb6	534	36	the	the	DT
cord-018265-twp33bb6	534	37	introduction	introduction	NN
cord-018265-twp33bb6	534	38	of	of	IN
cord-018265-twp33bb6	534	39	protein	protein	NN
cord-018265-twp33bb6	534	40	-	-	HYPH
cord-018265-twp33bb6	534	41	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	534	42	conjugate	conjugate	NN
cord-018265-twp33bb6	534	43	vaccine	vaccine	NN
cord-018265-twp33bb6	534	44	Pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	534	45	vaccines	vaccine	NNS
cord-018265-twp33bb6	534	46	:	:	:
cord-018265-twp33bb6	534	47	an	an	DT
cord-018265-twp33bb6	534	48	update	update	NN
cord-018265-twp33bb6	534	49	on	on	IN
cord-018265-twp33bb6	534	50	current	current	JJ
cord-018265-twp33bb6	534	51	strategies	strategy	NNS
cord-018265-twp33bb6	535	1	The	the	DT
cord-018265-twp33bb6	535	2	epidemiology	epidemiology	NN
cord-018265-twp33bb6	535	3	and	and	CC
cord-018265-twp33bb6	535	4	prevention	prevention	NN
cord-018265-twp33bb6	535	5	of	of	IN
cord-018265-twp33bb6	535	6	disease	disease	NN
cord-018265-twp33bb6	535	7	caused	cause	VBN
cord-018265-twp33bb6	535	8	by	by	IN
cord-018265-twp33bb6	535	9	Haemophilus	Haemophilus	NNP
cord-018265-twp33bb6	535	10	influenzae	influenzae	NN
cord-018265-twp33bb6	535	11	type	type	NN
cord-018265-twp33bb6	535	12	b	b	NNP
cord-018265-twp33bb6	535	13	Prevention	Prevention	NNP
cord-018265-twp33bb6	535	14	of	of	IN
cord-018265-twp33bb6	535	15	Hemophilus	Hemophilus	NNP
cord-018265-twp33bb6	535	16	influenzae	influenzae	NN
cord-018265-twp33bb6	535	17	type	type	NN
cord-018265-twp33bb6	535	18	b	b	LS
cord-018265-twp33bb6	535	19	bacteremic	bacteremic	JJ
cord-018265-twp33bb6	535	20	infections	infection	NNS
cord-018265-twp33bb6	535	21	with	with	IN
cord-018265-twp33bb6	535	22	the	the	DT
cord-018265-twp33bb6	535	23	capsular	capsular	JJ
cord-018265-twp33bb6	535	24	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	535	25	vaccine	vaccine	NN
cord-018265-twp33bb6	536	1	The	the	DT
cord-018265-twp33bb6	536	2	1996	1996	CD
cord-018265-twp33bb6	536	3	Albert	Albert	NNP
cord-018265-twp33bb6	536	4	Lasker	Lasker	NNP
cord-018265-twp33bb6	536	5	Medical	Medical	NNP
cord-018265-twp33bb6	536	6	Research	Research	NNP
cord-018265-twp33bb6	536	7	Awards	Awards	NNPS
cord-018265-twp33bb6	536	8	.	.	.
cord-018265-twp33bb6	537	1	Prevention	prevention	NN
cord-018265-twp33bb6	537	2	of	of	IN
cord-018265-twp33bb6	537	3	systemic	systemic	JJ
cord-018265-twp33bb6	537	4	infections	infection	NNS
cord-018265-twp33bb6	537	5	,	,	,
cord-018265-twp33bb6	537	6	especially	especially	RB
cord-018265-twp33bb6	537	7	meningitis	meningitis	NN
cord-018265-twp33bb6	537	8	,	,	,
cord-018265-twp33bb6	537	9	caused	cause	VBN
cord-018265-twp33bb6	537	10	by	by	IN
cord-018265-twp33bb6	537	11	Haemophilus	Haemophilus	NNP
cord-018265-twp33bb6	537	12	influenzae	influenzae	NN
cord-018265-twp33bb6	537	13	type	type	NN
cord-018265-twp33bb6	537	14	b.	b.	NN
cord-018265-twp33bb6	537	15	Impact	Impact	NNP
cord-018265-twp33bb6	537	16	on	on	IN
cord-018265-twp33bb6	537	17	public	public	JJ
cord-018265-twp33bb6	537	18	health	health	NN
cord-018265-twp33bb6	537	19	and	and	CC
cord-018265-twp33bb6	537	20	implications	implication	NNS
cord-018265-twp33bb6	537	21	for	for	IN
cord-018265-twp33bb6	537	22	other	other	JJ
cord-018265-twp33bb6	537	23	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	537	24	-	-	HYPH
cord-018265-twp33bb6	537	25	based	base	VBN
cord-018265-twp33bb6	537	26	vaccines	vaccine	NNS
cord-018265-twp33bb6	537	27	Haemophilus	Haemophilus	NNP
cord-018265-twp33bb6	537	28	influenzae	influenzae	NN
cord-018265-twp33bb6	537	29	type	type	NN
cord-018265-twp33bb6	537	30	b	b	NN
cord-018265-twp33bb6	537	31	vaccines	vaccine	NNS
cord-018265-twp33bb6	537	32	:	:	:
cord-018265-twp33bb6	537	33	history	history	NN
cord-018265-twp33bb6	537	34	,	,	,
cord-018265-twp33bb6	537	35	choice	choice	NN
cord-018265-twp33bb6	537	36	and	and	CC
cord-018265-twp33bb6	537	37	comparisons	comparison	NNS
cord-018265-twp33bb6	538	1	The	the	DT
cord-018265-twp33bb6	538	2	use	use	NN
cord-018265-twp33bb6	538	3	of	of	IN
cord-018265-twp33bb6	538	4	Haemophilus	haemophilus	JJ
cord-018265-twp33bb6	538	5	influenzae	influenzae	NN
cord-018265-twp33bb6	538	6	type	type	NN
cord-018265-twp33bb6	538	7	b	b	NN
cord-018265-twp33bb6	538	8	-	-	HYPH
cord-018265-twp33bb6	538	9	tetanus	tetanus	JJ
cord-018265-twp33bb6	538	10	toxoid	toxoid	NN
cord-018265-twp33bb6	538	11	conjugate	conjugate	JJ
cord-018265-twp33bb6	538	12	vaccine	vaccine	NN
cord-018265-twp33bb6	538	13	mixed	mix	VBN
cord-018265-twp33bb6	538	14	with	with	IN
cord-018265-twp33bb6	538	15	diphtheria	diphtheria	NN
cord-018265-twp33bb6	538	16	-	-	HYPH
cord-018265-twp33bb6	538	17	tetanus	tetanus	NN
cord-018265-twp33bb6	538	18	-	-	HYPH
cord-018265-twp33bb6	538	19	pertussis	pertussis	NN
cord-018265-twp33bb6	538	20	vaccine	vaccine	NN
cord-018265-twp33bb6	538	21	in	in	IN
cord-018265-twp33bb6	538	22	Gambian	gambian	JJ
cord-018265-twp33bb6	538	23	infants	infant	NNS
cord-018265-twp33bb6	539	1	Randomised	randomised	JJ
cord-018265-twp33bb6	539	2	trial	trial	NN
cord-018265-twp33bb6	539	3	of	of	IN
cord-018265-twp33bb6	539	4	Haemophilus	haemophilus	JJ
cord-018265-twp33bb6	539	5	influenzae	influenzae	NN
cord-018265-twp33bb6	539	6	type	type	NN
cord-018265-twp33bb6	539	7	-	-	HYPH
cord-018265-twp33bb6	539	8	b	b	NN
cord-018265-twp33bb6	539	9	tetanus	tetanus	NN
cord-018265-twp33bb6	539	10	protein	protein	NN
cord-018265-twp33bb6	539	11	conjugate	conjugate	NN
cord-018265-twp33bb6	539	12	vaccine	vaccine	NN
cord-018265-twp33bb6	539	13	[	[	-LRB-
cord-018265-twp33bb6	539	14	corrected	correct	VBD
cord-018265-twp33bb6	539	15	]	]	-RRB-
cord-018265-twp33bb6	539	16	for	for	IN
cord-018265-twp33bb6	539	17	prevention	prevention	NN
cord-018265-twp33bb6	539	18	of	of	IN
cord-018265-twp33bb6	539	19	pneumonia	pneumonia	NN
cord-018265-twp33bb6	539	20	and	and	CC
cord-018265-twp33bb6	539	21	meningitis	meningitis	NN
cord-018265-twp33bb6	539	22	in	in	IN
cord-018265-twp33bb6	539	23	Gambian	gambian	JJ
cord-018265-twp33bb6	539	24	infants	infant	NNS
cord-018265-twp33bb6	540	1	Haemophilus	haemophilus	JJ
cord-018265-twp33bb6	540	2	influenzae	influenzae	NN
cord-018265-twp33bb6	540	3	type	type	NN
cord-018265-twp33bb6	540	4	b	b	NN
cord-018265-twp33bb6	540	5	conjugate	conjugate	VB
cord-018265-twp33bb6	540	6	vaccines	vaccine	NNS
cord-018265-twp33bb6	540	7	:	:	:
cord-018265-twp33bb6	540	8	a	a	DT
cord-018265-twp33bb6	540	9	review	review	NN
cord-018265-twp33bb6	540	10	of	of	IN
cord-018265-twp33bb6	540	11	efficacy	efficacy	NN
cord-018265-twp33bb6	540	12	data	datum	NNS
cord-018265-twp33bb6	540	13	Large	large	JJ
cord-018265-twp33bb6	540	14	scale	scale	NN
cord-018265-twp33bb6	540	15	,	,	,
cord-018265-twp33bb6	540	16	postlicensure	postlicensure	NN
cord-018265-twp33bb6	540	17	,	,	,
cord-018265-twp33bb6	540	18	selective	selective	JJ
cord-018265-twp33bb6	540	19	vaccination	vaccination	NN
cord-018265-twp33bb6	540	20	of	of	IN
cord-018265-twp33bb6	540	21	Chilean	chilean	JJ
cord-018265-twp33bb6	540	22	infants	infant	NNS
cord-018265-twp33bb6	540	23	with	with	IN
cord-018265-twp33bb6	540	24	PRP	PRP	NNP
cord-018265-twp33bb6	540	25	-	-	HYPH
cord-018265-twp33bb6	540	26	T	T	NNP
cord-018265-twp33bb6	540	27	conjugate	conjugate	NN
cord-018265-twp33bb6	540	28	vaccine	vaccine	NN
cord-018265-twp33bb6	540	29	:	:	:
cord-018265-twp33bb6	540	30	practicality	practicality	NN
cord-018265-twp33bb6	540	31	and	and	CC
cord-018265-twp33bb6	540	32	effectiveness	effectiveness	NN
cord-018265-twp33bb6	540	33	in	in	IN
cord-018265-twp33bb6	540	34	preventing	prevent	VBG
cord-018265-twp33bb6	540	35	invasive	invasive	JJ
cord-018265-twp33bb6	540	36	Haemophilus	Haemophilus	NNP
cord-018265-twp33bb6	540	37	influenzae	influenzae	NN
cord-018265-twp33bb6	540	38	type	type	NN
cord-018265-twp33bb6	540	39	b	b	NN
cord-018265-twp33bb6	540	40	infections	infection	NNS
cord-018265-twp33bb6	540	41	Biological	biological	JJ
cord-018265-twp33bb6	540	42	activity	activity	NN
cord-018265-twp33bb6	540	43	of	of	IN
cord-018265-twp33bb6	540	44	serum	serum	NN
cord-018265-twp33bb6	540	45	antibodies	antibody	NNS
cord-018265-twp33bb6	540	46	to	to	IN
cord-018265-twp33bb6	540	47	a	a	DT
cord-018265-twp33bb6	540	48	nonacylated	nonacylated	JJ
cord-018265-twp33bb6	540	49	form	form	NN
cord-018265-twp33bb6	540	50	of	of	IN
cord-018265-twp33bb6	540	51	lipoprotein	lipoprotein	NN
cord-018265-twp33bb6	540	52	D	d	NN
cord-018265-twp33bb6	540	53	of	of	IN
cord-018265-twp33bb6	540	54	Haemophilus	Haemophilus	NNP
cord-018265-twp33bb6	540	55	influenzae	influenzae	NN
cord-018265-twp33bb6	540	56	Enhanced	enhanced	JJ
cord-018265-twp33bb6	540	57	respiratory	respiratory	JJ
cord-018265-twp33bb6	540	58	clearance	clearance	NN
cord-018265-twp33bb6	540	59	of	of	IN
cord-018265-twp33bb6	540	60	nontypeable	nontypeable	JJ
cord-018265-twp33bb6	540	61	Haemophilus	Haemophilus	NNP
cord-018265-twp33bb6	540	62	influenzae	influenzae	NN
cord-018265-twp33bb6	540	63	following	follow	VBG
cord-018265-twp33bb6	540	64	mucosal	mucosal	JJ
cord-018265-twp33bb6	540	65	immunization	immunization	NN
cord-018265-twp33bb6	540	66	with	with	IN
cord-018265-twp33bb6	540	67	P6	p6	NN
cord-018265-twp33bb6	540	68	in	in	IN
cord-018265-twp33bb6	540	69	a	a	DT
cord-018265-twp33bb6	540	70	rat	rat	NN
cord-018265-twp33bb6	540	71	model	model	NN
cord-018265-twp33bb6	541	1	Intranasal	intranasal	NN
cord-018265-twp33bb6	541	2	immunization	immunization	NN
cord-018265-twp33bb6	541	3	with	with	IN
cord-018265-twp33bb6	541	4	recombinant	recombinant	JJ
cord-018265-twp33bb6	541	5	outer	outer	JJ
cord-018265-twp33bb6	541	6	membrane	membrane	NN
cord-018265-twp33bb6	541	7	protein	protein	NN
cord-018265-twp33bb6	541	8	P6	P6	NNP
cord-018265-twp33bb6	541	9	induces	induce	VBZ
cord-018265-twp33bb6	541	10	specific	specific	JJ
cord-018265-twp33bb6	541	11	immune	immune	JJ
cord-018265-twp33bb6	541	12	responses	response	NNS
cord-018265-twp33bb6	541	13	against	against	IN
cord-018265-twp33bb6	541	14	nontypeable	nontypeable	JJ
cord-018265-twp33bb6	541	15	Haemophilus	Haemophilus	NNP
cord-018265-twp33bb6	541	16	influenzae	influenzae	NN
cord-018265-twp33bb6	542	1	Intranasal	intranasal	NN
cord-018265-twp33bb6	542	2	vaccination	vaccination	NN
cord-018265-twp33bb6	542	3	with	with	IN
cord-018265-twp33bb6	542	4	recombinant	recombinant	JJ
cord-018265-twp33bb6	542	5	P6	p6	NN
cord-018265-twp33bb6	542	6	protein	protein	NN
cord-018265-twp33bb6	542	7	and	and	CC
cord-018265-twp33bb6	542	8	adamantylamide	adamantylamide	NN
cord-018265-twp33bb6	542	9	dipeptide	dipeptide	NN
cord-018265-twp33bb6	542	10	as	as	IN
cord-018265-twp33bb6	542	11	mucosal	mucosal	JJ
cord-018265-twp33bb6	542	12	adjuvant	adjuvant	NN
cord-018265-twp33bb6	542	13	confers	confer	VBZ
cord-018265-twp33bb6	542	14	efficient	efficient	JJ
cord-018265-twp33bb6	542	15	protection	protection	NN
cord-018265-twp33bb6	542	16	against	against	IN
cord-018265-twp33bb6	542	17	otitis	otitis	NN
cord-018265-twp33bb6	542	18	media	medium	NNS
cord-018265-twp33bb6	542	19	and	and	CC
cord-018265-twp33bb6	542	20	lung	lung	NN
cord-018265-twp33bb6	542	21	infection	infection	NN
cord-018265-twp33bb6	542	22	by	by	IN
cord-018265-twp33bb6	542	23	nontypeable	nontypeable	JJ
cord-018265-twp33bb6	542	24	Haemophilus	Haemophilus	NNP
cord-018265-twp33bb6	542	25	influenzae	influenzae	NN
cord-018265-twp33bb6	542	26	DTP	dtp	NN
cord-018265-twp33bb6	542	27	-	-	HYPH
cord-018265-twp33bb6	542	28	associated	associate	VBN
cord-018265-twp33bb6	542	29	reactions	reaction	NNS
cord-018265-twp33bb6	542	30	:	:	:
cord-018265-twp33bb6	542	31	an	an	DT
cord-018265-twp33bb6	542	32	analysis	analysis	NN
cord-018265-twp33bb6	542	33	by	by	IN
cord-018265-twp33bb6	542	34	injection	injection	NN
cord-018265-twp33bb6	542	35	site	site	NN
cord-018265-twp33bb6	542	36	,	,	,
cord-018265-twp33bb6	542	37	manufacturer	manufacturer	NN
cord-018265-twp33bb6	542	38	,	,	,
cord-018265-twp33bb6	542	39	prior	prior	JJ
cord-018265-twp33bb6	542	40	reactions	reaction	NNS
cord-018265-twp33bb6	542	41	,	,	,
cord-018265-twp33bb6	542	42	and	and	CC
cord-018265-twp33bb6	542	43	dose	dose	VB
cord-018265-twp33bb6	542	44	Development	Development	NNP
cord-018265-twp33bb6	542	45	of	of	IN
cord-018265-twp33bb6	542	46	a	a	DT
cord-018265-twp33bb6	542	47	pertussis	pertussis	NN
cord-018265-twp33bb6	542	48	component	component	NN
cord-018265-twp33bb6	542	49	vaccine	vaccine	NN
cord-018265-twp33bb6	542	50	in	in	IN
cord-018265-twp33bb6	542	51	Japan	Japan	NNP
cord-018265-twp33bb6	542	52	Placebo	Placebo	NNP
cord-018265-twp33bb6	542	53	-	-	HYPH
cord-018265-twp33bb6	542	54	controlled	control	VBN
cord-018265-twp33bb6	542	55	trial	trial	NN
cord-018265-twp33bb6	542	56	of	of	IN
cord-018265-twp33bb6	542	57	two	two	CD
cord-018265-twp33bb6	542	58	acellular	acellular	JJ
cord-018265-twp33bb6	542	59	pertussis	pertussis	NN
cord-018265-twp33bb6	542	60	vaccines	vaccine	NNS
cord-018265-twp33bb6	542	61	in	in	IN
cord-018265-twp33bb6	542	62	Sweden	Sweden	NNP
cord-018265-twp33bb6	542	63	-protective	-protective	JJ
cord-018265-twp33bb6	542	64	efficacy	efficacy	NN
cord-018265-twp33bb6	542	65	and	and	CC
cord-018265-twp33bb6	542	66	adverse	adverse	JJ
cord-018265-twp33bb6	542	67	events	event	NNS
cord-018265-twp33bb6	543	1	Secondary	secondary	JJ
cord-018265-twp33bb6	543	2	analyses	analysis	NNS
cord-018265-twp33bb6	543	3	of	of	IN
cord-018265-twp33bb6	543	4	the	the	DT
cord-018265-twp33bb6	543	5	efficacy	efficacy	NN
cord-018265-twp33bb6	543	6	of	of	IN
cord-018265-twp33bb6	543	7	two	two	CD
cord-018265-twp33bb6	543	8	acellular	acellular	JJ
cord-018265-twp33bb6	543	9	pertussis	pertussis	NN
cord-018265-twp33bb6	543	10	vaccines	vaccine	NNS
cord-018265-twp33bb6	543	11	evaluated	evaluate	VBN
cord-018265-twp33bb6	543	12	in	in	IN
cord-018265-twp33bb6	543	13	a	a	DT
cord-018265-twp33bb6	543	14	Swedish	swedish	JJ
cord-018265-twp33bb6	543	15	phase	phase	NN
cord-018265-twp33bb6	543	16	III	iii	CD
cord-018265-twp33bb6	543	17	trial	trial	NN
cord-018265-twp33bb6	543	18	Analysis	Analysis	NNP
cord-018265-twp33bb6	543	19	of	of	IN
cord-018265-twp33bb6	543	20	Bordetella	Bordetella	NNP
cord-018265-twp33bb6	543	21	pertussis	pertussis	NN
cord-018265-twp33bb6	543	22	isolates	isolate	NNS
cord-018265-twp33bb6	543	23	collected	collect	VBN
cord-018265-twp33bb6	543	24	in	in	IN
cord-018265-twp33bb6	543	25	Japan	Japan	NNP
cord-018265-twp33bb6	543	26	before	before	RB
cord-018265-twp33bb6	543	27	and	and	CC
cord-018265-twp33bb6	544	1	after	after	IN
cord-018265-twp33bb6	544	2	introduction	introduction	NN
cord-018265-twp33bb6	544	3	of	of	IN
cord-018265-twp33bb6	544	4	acellular	acellular	JJ
cord-018265-twp33bb6	544	5	pertussis	pertussis	NN
cord-018265-twp33bb6	544	6	vaccines	vaccine	NNS
cord-018265-twp33bb6	544	7	Recommendations	recommendation	NNS
cord-018265-twp33bb6	544	8	are	be	VBP
cord-018265-twp33bb6	544	9	needed	need	VBN
cord-018265-twp33bb6	544	10	for	for	IN
cord-018265-twp33bb6	544	11	adolescent	adolescent	JJ
cord-018265-twp33bb6	544	12	and	and	CC
cord-018265-twp33bb6	544	13	adult	adult	NN
cord-018265-twp33bb6	544	14	pertussis	pertussis	NN
cord-018265-twp33bb6	544	15	immunisation	immunisation	NN
cord-018265-twp33bb6	544	16	:	:	:
cord-018265-twp33bb6	544	17	rationale	rationale	NN
cord-018265-twp33bb6	544	18	and	and	CC
cord-018265-twp33bb6	544	19	strategies	strategy	NNS
cord-018265-twp33bb6	544	20	for	for	IN
cord-018265-twp33bb6	544	21	consideration	consideration	NN
cord-018265-twp33bb6	544	22	Polymorphism	polymorphism	NN
cord-018265-twp33bb6	544	23	of	of	IN
cord-018265-twp33bb6	544	24	Bordetella	Bordetella	NNP
cord-018265-twp33bb6	544	25	pertussis	pertussis	NN
cord-018265-twp33bb6	544	26	isolates	isolate	VBZ
cord-018265-twp33bb6	544	27	circulating	circulate	VBG
cord-018265-twp33bb6	544	28	for	for	IN
cord-018265-twp33bb6	544	29	the	the	DT
cord-018265-twp33bb6	544	30	last	last	JJ
cord-018265-twp33bb6	544	31	10	10	CD
cord-018265-twp33bb6	544	32	years	year	NNS
cord-018265-twp33bb6	544	33	in	in	IN
cord-018265-twp33bb6	544	34	France	France	NNP
cord-018265-twp33bb6	544	35	,	,	,
cord-018265-twp33bb6	544	36	where	where	WRB
cord-018265-twp33bb6	544	37	a	a	DT
cord-018265-twp33bb6	544	38	single	single	JJ
cord-018265-twp33bb6	544	39	effective	effective	JJ
cord-018265-twp33bb6	544	40	whole	whole	JJ
cord-018265-twp33bb6	544	41	-	-	HYPH
cord-018265-twp33bb6	544	42	cell	cell	NN
cord-018265-twp33bb6	544	43	vaccine	vaccine	NN
cord-018265-twp33bb6	544	44	has	have	VBZ
cord-018265-twp33bb6	544	45	been	be	VBN
cord-018265-twp33bb6	544	46	used	use	VBN
cord-018265-twp33bb6	544	47	for	for	IN
cord-018265-twp33bb6	544	48	more	more	JJR
cord-018265-twp33bb6	544	49	than	than	IN
cord-018265-twp33bb6	544	50	30	30	CD
cord-018265-twp33bb6	544	51	years	year	NNS
cord-018265-twp33bb6	544	52	Comparison	comparison	NN
cord-018265-twp33bb6	544	53	of	of	IN
cord-018265-twp33bb6	544	54	acellular	acellular	JJ
cord-018265-twp33bb6	544	55	pertussis	pertussis	NN
cord-018265-twp33bb6	544	56	vaccines	vaccine	NNS
cord-018265-twp33bb6	544	57	-	-	:
cord-018265-twp33bb6	544	58	induced	induce	VBN
cord-018265-twp33bb6	544	59	immunity	immunity	NN
cord-018265-twp33bb6	544	60	against	against	IN
cord-018265-twp33bb6	544	61	infection	infection	NN
cord-018265-twp33bb6	544	62	due	due	IN
cord-018265-twp33bb6	544	63	to	to	IN
cord-018265-twp33bb6	544	64	Bordetellapertussis	bordetellapertussis	NN
cord-018265-twp33bb6	544	65	variant	variant	NN
cord-018265-twp33bb6	544	66	isolates	isolate	VBZ
cord-018265-twp33bb6	544	67	in	in	IN
cord-018265-twp33bb6	544	68	a	a	DT
cord-018265-twp33bb6	544	69	mouse	mouse	NN
cord-018265-twp33bb6	544	70	model	model	NN
cord-018265-twp33bb6	544	71	Analysis	Analysis	NNP
cord-018265-twp33bb6	544	72	of	of	IN
cord-018265-twp33bb6	544	73	Bordetella	Bordetella	NNP
cord-018265-twp33bb6	544	74	pertussis	pertussis	NN
cord-018265-twp33bb6	544	75	populations	population	NNS
cord-018265-twp33bb6	544	76	in	in	IN
cord-018265-twp33bb6	544	77	European	european	JJ
cord-018265-twp33bb6	544	78	countries	country	NNS
cord-018265-twp33bb6	544	79	with	with	IN
cord-018265-twp33bb6	544	80	different	different	JJ
cord-018265-twp33bb6	544	81	vaccination	vaccination	NN
cord-018265-twp33bb6	544	82	policies	policy	NNS
cord-018265-twp33bb6	544	83	Immunity	immunity	NN
cord-018265-twp33bb6	544	84	to	to	IN
cord-018265-twp33bb6	544	85	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	544	86	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	544	87	induced	induce	VBN
cord-018265-twp33bb6	544	88	by	by	IN
cord-018265-twp33bb6	544	89	vaccination	vaccination	NN
cord-018265-twp33bb6	544	90	with	with	IN
cord-018265-twp33bb6	544	91	DNA	dna	NN
cord-018265-twp33bb6	544	92	vectors	vector	NNS
cord-018265-twp33bb6	544	93	expressing	express	VBG
cord-018265-twp33bb6	544	94	a	a	DT
cord-018265-twp33bb6	544	95	cytoplasmic	cytoplasmic	JJ
cord-018265-twp33bb6	544	96	protein	protein	NN
cord-018265-twp33bb6	544	97	(	(	-LRB-
cord-018265-twp33bb6	544	98	Hsp60	Hsp60	NNP
cord-018265-twp33bb6	544	99	)	)	-RRB-
cord-018265-twp33bb6	544	100	or	or	CC
cord-018265-twp33bb6	544	101	outer	outer	JJ
cord-018265-twp33bb6	544	102	membrane	membrane	NN
cord-018265-twp33bb6	544	103	proteins	protein	NNS
cord-018265-twp33bb6	544	104	(	(	-LRB-
cord-018265-twp33bb6	544	105	MOMP	MOMP	NNP
cord-018265-twp33bb6	544	106	and	and	CC
cord-018265-twp33bb6	544	107	Omp2	Omp2	NNP
cord-018265-twp33bb6	544	108	)	)	-RRB-
cord-018265-twp33bb6	544	109	DNA	dna	NN
cord-018265-twp33bb6	544	110	immunization	immunization	NN
cord-018265-twp33bb6	544	111	followed	follow	VBN
cord-018265-twp33bb6	544	112	by	by	IN
cord-018265-twp33bb6	544	113	a	a	DT
cord-018265-twp33bb6	544	114	viral	viral	JJ
cord-018265-twp33bb6	544	115	vector	vector	NN
cord-018265-twp33bb6	544	116	booster	booster	NN
cord-018265-twp33bb6	544	117	in	in	IN
cord-018265-twp33bb6	544	118	a	a	DT
cord-018265-twp33bb6	544	119	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	544	120	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	544	121	mouse	mouse	NN
cord-018265-twp33bb6	544	122	model	model	NN
cord-018265-twp33bb6	545	1	A	a	DT
cord-018265-twp33bb6	545	2	CD8	CD8	NNP
cord-018265-twp33bb6	545	3	+	+	CC
cord-018265-twp33bb6	545	4	T	T	NNP
cord-018265-twp33bb6	545	5	cell	cell	NN
cord-018265-twp33bb6	545	6	heptaepitope	heptaepitope	NNP
cord-018265-twp33bb6	545	7	minigene	minigene	NNP
cord-018265-twp33bb6	545	8	vaccine	vaccine	NNP
cord-018265-twp33bb6	545	9	induces	induce	VBZ
cord-018265-twp33bb6	545	10	protective	protective	JJ
cord-018265-twp33bb6	545	11	immunity	immunity	NN
cord-018265-twp33bb6	545	12	against	against	IN
cord-018265-twp33bb6	545	13	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	545	14	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	545	15	Identification	identification	NN
cord-018265-twp33bb6	545	16	of	of	IN
cord-018265-twp33bb6	545	17	new	new	JJ
cord-018265-twp33bb6	545	18	potential	potential	JJ
cord-018265-twp33bb6	545	19	vaccine	vaccine	NN
cord-018265-twp33bb6	545	20	candidates	candidate	NNS
cord-018265-twp33bb6	545	21	against	against	IN
cord-018265-twp33bb6	545	22	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	545	23	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	545	24	by	by	IN
cord-018265-twp33bb6	545	25	multiple	multiple	JJ
cord-018265-twp33bb6	545	26	screenings	screening	NNS
cord-018265-twp33bb6	545	27	Genomic	genomic	JJ
cord-018265-twp33bb6	545	28	approach	approach	NN
cord-018265-twp33bb6	545	29	for	for	IN
cord-018265-twp33bb6	545	30	analysis	analysis	NN
cord-018265-twp33bb6	545	31	of	of	IN
cord-018265-twp33bb6	545	32	surface	surface	NN
cord-018265-twp33bb6	545	33	proteins	protein	NNS
cord-018265-twp33bb6	545	34	in	in	IN
cord-018265-twp33bb6	545	35	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	545	36	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	546	1	The	the	DT
cord-018265-twp33bb6	546	2	major	major	JJ
cord-018265-twp33bb6	546	3	outer	outer	JJ
cord-018265-twp33bb6	546	4	membrane	membrane	NN
cord-018265-twp33bb6	546	5	protein	protein	NN
cord-018265-twp33bb6	546	6	,	,	,
cord-018265-twp33bb6	546	7	CD	CD	NNP
cord-018265-twp33bb6	546	8	,	,	,
cord-018265-twp33bb6	546	9	extracted	extract	VBN
cord-018265-twp33bb6	546	10	from	from	IN
cord-018265-twp33bb6	546	11	Moraxella	Moraxella	NNP
cord-018265-twp33bb6	547	1	(	(	-LRB-
cord-018265-twp33bb6	547	2	Branhamella	Branhamella	NNP
cord-018265-twp33bb6	547	3	)	)	-RRB-
cord-018265-twp33bb6	547	4	catarrhalis	catarrhalis	NNP
cord-018265-twp33bb6	547	5	is	be	VBZ
cord-018265-twp33bb6	547	6	a	a	DT
cord-018265-twp33bb6	547	7	potential	potential	JJ
cord-018265-twp33bb6	547	8	vaccine	vaccine	NN
cord-018265-twp33bb6	547	9	antigen	antigen	NN
cord-018265-twp33bb6	547	10	that	that	WDT
cord-018265-twp33bb6	547	11	induces	induce	VBZ
cord-018265-twp33bb6	547	12	bactericidal	bactericidal	JJ
cord-018265-twp33bb6	547	13	antibodies	antibody	NNS
cord-018265-twp33bb6	547	14	Evaluation	Evaluation	NNP
cord-018265-twp33bb6	547	15	of	of	IN
cord-018265-twp33bb6	547	16	purified	purify	VBN
cord-018265-twp33bb6	547	17	UspA	UspA	NNP
cord-018265-twp33bb6	547	18	from	from	IN
cord-018265-twp33bb6	547	19	Moraxella	Moraxella	NNP
cord-018265-twp33bb6	547	20	catarrhalis	catarrhalis	NNP
cord-018265-twp33bb6	547	21	as	as	IN
cord-018265-twp33bb6	547	22	a	a	DT
cord-018265-twp33bb6	547	23	vaccine	vaccine	NN
cord-018265-twp33bb6	547	24	in	in	IN
cord-018265-twp33bb6	547	25	a	a	DT
cord-018265-twp33bb6	547	26	murine	murine	JJ
cord-018265-twp33bb6	547	27	model	model	NN
cord-018265-twp33bb6	547	28	after	after	IN
cord-018265-twp33bb6	547	29	active	active	JJ
cord-018265-twp33bb6	547	30	immunization	immunization	NN
cord-018265-twp33bb6	547	31	Progress	Progress	NNP
cord-018265-twp33bb6	547	32	toward	toward	IN
cord-018265-twp33bb6	547	33	the	the	DT
cord-018265-twp33bb6	547	34	development	development	NN
cord-018265-twp33bb6	547	35	of	of	IN
cord-018265-twp33bb6	547	36	a	a	DT
cord-018265-twp33bb6	547	37	vaccine	vaccine	NN
cord-018265-twp33bb6	547	38	to	to	TO
cord-018265-twp33bb6	547	39	prevent	prevent	VB
cord-018265-twp33bb6	547	40	Moraxella	Moraxella	NNP
cord-018265-twp33bb6	547	41	(	(	-LRB-
cord-018265-twp33bb6	547	42	Branhamella	Branhamella	NNP
cord-018265-twp33bb6	547	43	)	)	-RRB-
cord-018265-twp33bb6	548	1	catarrhalis	catarrhalis	JJ
cord-018265-twp33bb6	548	2	infections	infection	NNS
cord-018265-twp33bb6	549	1	Specific	specific	JJ
cord-018265-twp33bb6	549	2	immune	immune	JJ
cord-018265-twp33bb6	549	3	responses	response	NNS
cord-018265-twp33bb6	549	4	and	and	CC
cord-018265-twp33bb6	549	5	enhancement	enhancement	NN
cord-018265-twp33bb6	549	6	of	of	IN
cord-018265-twp33bb6	549	7	murine	murine	JJ
cord-018265-twp33bb6	549	8	pulmonary	pulmonary	JJ
cord-018265-twp33bb6	549	9	clearance	clearance	NN
cord-018265-twp33bb6	549	10	of	of	IN
cord-018265-twp33bb6	549	11	Moraxella	Moraxella	NNP
cord-018265-twp33bb6	549	12	catarrhalis	catarrhali	VBN
cord-018265-twp33bb6	549	13	by	by	IN
cord-018265-twp33bb6	549	14	intranasal	intranasal	NN
cord-018265-twp33bb6	549	15	immunization	immunization	NN
cord-018265-twp33bb6	549	16	with	with	IN
cord-018265-twp33bb6	549	17	a	a	DT
cord-018265-twp33bb6	549	18	detoxified	detoxify	VBN
cord-018265-twp33bb6	549	19	lipooligosaccharide	lipooligosaccharide	NN
cord-018265-twp33bb6	549	20	conjugate	conjugate	NN
cord-018265-twp33bb6	549	21	vaccine	vaccine	NN
cord-018265-twp33bb6	549	22	Synthesis	Synthesis	NNP
cord-018265-twp33bb6	549	23	and	and	CC
cord-018265-twp33bb6	549	24	characterization	characterization	NN
cord-018265-twp33bb6	549	25	of	of	IN
cord-018265-twp33bb6	549	26	lipooligosaccharidebased	lipooligosaccharidebased	JJ
cord-018265-twp33bb6	549	27	conjugate	conjugate	NN
cord-018265-twp33bb6	549	28	vaccines	vaccine	NNS
cord-018265-twp33bb6	549	29	for	for	IN
cord-018265-twp33bb6	549	30	serotype	serotype	NN
cord-018265-twp33bb6	549	31	B	B	NNP
cord-018265-twp33bb6	549	32	Moraxella	Moraxella	NNP
cord-018265-twp33bb6	549	33	catarrhalis	catarrhalis	NNP
cord-018265-twp33bb6	550	1	Mycoplasmas	mycoplasmas	NN
cord-018265-twp33bb6	550	2	:	:	:
cord-018265-twp33bb6	550	3	sophisticated	sophisticated	JJ
cord-018265-twp33bb6	550	4	,	,	,
cord-018265-twp33bb6	550	5	reemerging	reemerge	VBG
cord-018265-twp33bb6	550	6	,	,	,
cord-018265-twp33bb6	550	7	and	and	CC
cord-018265-twp33bb6	550	8	burdened	burden	VBN
cord-018265-twp33bb6	550	9	by	by	IN
cord-018265-twp33bb6	550	10	their	-PRON-	PRP$
cord-018265-twp33bb6	550	11	notoriety	notoriety	NN
cord-018265-twp33bb6	550	12	Inactivated	inactivate	VBD
cord-018265-twp33bb6	550	13	Mycoplasma	Mycoplasma	NNP
cord-018265-twp33bb6	550	14	pneumoniae	pneumoniae	NN
cord-018265-twp33bb6	550	15	vaccine	vaccine	NN
cord-018265-twp33bb6	550	16	.	.	.
cord-018265-twp33bb6	551	1	Evaluation	evaluation	NN
cord-018265-twp33bb6	551	2	in	in	IN
cord-018265-twp33bb6	551	3	volunteers	volunteer	NNS
cord-018265-twp33bb6	551	4	Mycoplasma	Mycoplasma	NNP
cord-018265-twp33bb6	551	5	pneumoniae	pneumoniae	NNS
cord-018265-twp33bb6	551	6	and	and	CC
cord-018265-twp33bb6	551	7	its	-PRON-	PRP$
cord-018265-twp33bb6	551	8	role	role	NN
cord-018265-twp33bb6	551	9	as	as	IN
cord-018265-twp33bb6	551	10	a	a	DT
cord-018265-twp33bb6	551	11	human	human	JJ
cord-018265-twp33bb6	551	12	pathogen	pathogen	NN
cord-018265-twp33bb6	551	13	Classification	classification	NN
cord-018265-twp33bb6	551	14	of	of	IN
cord-018265-twp33bb6	551	15	the	the	DT
cord-018265-twp33bb6	551	16	Legionnaires	Legionnaires	NNPS
cord-018265-twp33bb6	551	17	'	'	POS
cord-018265-twp33bb6	551	18	disease	disease	NN
cord-018265-twp33bb6	551	19	bacterium	bacterium	NN
cord-018265-twp33bb6	551	20	:	:	:
cord-018265-twp33bb6	551	21	Legionella	legionella	NN
cord-018265-twp33bb6	551	22	pneumophila	pneumophila	NN
cord-018265-twp33bb6	551	23	,	,	,
cord-018265-twp33bb6	551	24	genus	genus	NNP
cord-018265-twp33bb6	551	25	novum	novum	NNP
cord-018265-twp33bb6	551	26	,	,	,
cord-018265-twp33bb6	551	27	species	species	NNP
cord-018265-twp33bb6	551	28	nova	nova	NNP
cord-018265-twp33bb6	551	29	,	,	,
cord-018265-twp33bb6	551	30	of	of	IN
cord-018265-twp33bb6	551	31	the	the	DT
cord-018265-twp33bb6	551	32	family	family	NN
cord-018265-twp33bb6	551	33	Legionellaceae	Legionellaceae	NNP
cord-018265-twp33bb6	551	34	,	,	,
cord-018265-twp33bb6	551	35	familia	familia	NNP
cord-018265-twp33bb6	551	36	nova	nova	NNP
cord-018265-twp33bb6	551	37	Legionnaires	Legionnaires	NNPS
cord-018265-twp33bb6	551	38	'	'	POS
cord-018265-twp33bb6	551	39	disease	disease	NN
cord-018265-twp33bb6	551	40	:	:	:
cord-018265-twp33bb6	551	41	isolation	isolation	NN
cord-018265-twp33bb6	551	42	of	of	IN
cord-018265-twp33bb6	551	43	a	a	DT
cord-018265-twp33bb6	551	44	bacterium	bacterium	NN
cord-018265-twp33bb6	551	45	and	and	CC
cord-018265-twp33bb6	551	46	demonstration	demonstration	NN
cord-018265-twp33bb6	551	47	of	of	IN
cord-018265-twp33bb6	551	48	its	-PRON-	PRP$
cord-018265-twp33bb6	551	49	role	role	NN
cord-018265-twp33bb6	551	50	in	in	IN
cord-018265-twp33bb6	551	51	other	other	JJ
cord-018265-twp33bb6	551	52	respiratory	respiratory	JJ
cord-018265-twp33bb6	551	53	disease	disease	NN
cord-018265-twp33bb6	551	54	Vaccination	vaccination	NN
cord-018265-twp33bb6	551	55	with	with	IN
cord-018265-twp33bb6	551	56	the	the	DT
cord-018265-twp33bb6	551	57	major	major	JJ
cord-018265-twp33bb6	551	58	secretory	secretory	JJ
cord-018265-twp33bb6	551	59	protein	protein	NN
cord-018265-twp33bb6	551	60	of	of	IN
cord-018265-twp33bb6	551	61	Legionella	Legionella	NNP
cord-018265-twp33bb6	551	62	pneumophila	pneumophila	NN
cord-018265-twp33bb6	551	63	induces	induce	VBZ
cord-018265-twp33bb6	551	64	cell	cell	NN
cord-018265-twp33bb6	551	65	-	-	HYPH
cord-018265-twp33bb6	551	66	mediated	mediate	VBN
cord-018265-twp33bb6	551	67	and	and	CC
cord-018265-twp33bb6	551	68	protective	protective	JJ
cord-018265-twp33bb6	551	69	immunity	immunity	NN
cord-018265-twp33bb6	551	70	in	in	IN
cord-018265-twp33bb6	551	71	a	a	DT
cord-018265-twp33bb6	551	72	guinea	guinea	NN
cord-018265-twp33bb6	551	73	pig	pig	NN
cord-018265-twp33bb6	551	74	model	model	NN
cord-018265-twp33bb6	551	75	of	of	IN
cord-018265-twp33bb6	551	76	Legionnaires	Legionnaires	NNPS
cord-018265-twp33bb6	551	77	'	'	POS
cord-018265-twp33bb6	551	78	disease	disease	NN
cord-018265-twp33bb6	551	79	Vaccination	vaccination	NN
cord-018265-twp33bb6	551	80	against	against	IN
cord-018265-twp33bb6	551	81	Legionella	Legionella	NNP
cord-018265-twp33bb6	551	82	pneumophila	pneumophila	NN
cord-018265-twp33bb6	551	83	:	:	:
cord-018265-twp33bb6	551	84	serum	serum	NN
cord-018265-twp33bb6	551	85	antibody	antibody	NN
cord-018265-twp33bb6	551	86	correlates	correlate	VBZ
cord-018265-twp33bb6	551	87	with	with	IN
cord-018265-twp33bb6	551	88	protection	protection	NN
cord-018265-twp33bb6	551	89	induced	induce	VBN
cord-018265-twp33bb6	551	90	by	by	IN
cord-018265-twp33bb6	551	91	heat	heat	NN
cord-018265-twp33bb6	551	92	-	-	HYPH
cord-018265-twp33bb6	551	93	killed	kill	VBN
cord-018265-twp33bb6	551	94	or	or	CC
cord-018265-twp33bb6	551	95	acetone	acetone	NN
cord-018265-twp33bb6	551	96	-	-	HYPH
cord-018265-twp33bb6	551	97	killed	kill	VBN
cord-018265-twp33bb6	551	98	cells	cell	NNS
cord-018265-twp33bb6	551	99	against	against	IN
cord-018265-twp33bb6	551	100	intraperitoneal	intraperitoneal	JJ
cord-018265-twp33bb6	551	101	but	but	CC
cord-018265-twp33bb6	551	102	not	not	RB
cord-018265-twp33bb6	551	103	aerosol	aerosol	NN
cord-018265-twp33bb6	551	104	infection	infection	NN
cord-018265-twp33bb6	551	105	in	in	IN
cord-018265-twp33bb6	551	106	guinea	guinea	NN
cord-018265-twp33bb6	551	107	pigs	pig	NNS
cord-018265-twp33bb6	551	108	Induction	Induction	NNP
cord-018265-twp33bb6	551	109	of	of	IN
cord-018265-twp33bb6	551	110	protective	protective	JJ
cord-018265-twp33bb6	551	111	immunity	immunity	NN
cord-018265-twp33bb6	551	112	by	by	IN
cord-018265-twp33bb6	551	113	Legionella	Legionella	NNP
cord-018265-twp33bb6	551	114	pneumophila	pneumophila	NN
cord-018265-twp33bb6	551	115	flagellum	flagellum	NN
cord-018265-twp33bb6	551	116	in	in	IN
cord-018265-twp33bb6	551	117	an	an	DT
cord-018265-twp33bb6	551	118	A	A	NNP
cord-018265-twp33bb6	551	119	/	/	SYM
cord-018265-twp33bb6	551	120	J	J	NNP
cord-018265-twp33bb6	551	121	mouse	mouse	NN
cord-018265-twp33bb6	551	122	model	model	NN
cord-018265-twp33bb6	551	123	Legionella	Legionella	NNP
cord-018265-twp33bb6	551	124	pneumophila	pneumophila	NN
cord-018265-twp33bb6	551	125	immunity	immunity	NN
cord-018265-twp33bb6	551	126	and	and	CC
cord-018265-twp33bb6	551	127	immunomodulation	immunomodulation	NN
cord-018265-twp33bb6	551	128	:	:	:
cord-018265-twp33bb6	551	129	nature	nature	NN
cord-018265-twp33bb6	551	130	and	and	CC
cord-018265-twp33bb6	551	131	mechanisms	mechanism	NNS
cord-018265-twp33bb6	551	132	Major	major	JJ
cord-018265-twp33bb6	551	133	cytoplasmic	cytoplasmic	JJ
cord-018265-twp33bb6	551	134	membrane	membrane	NN
cord-018265-twp33bb6	551	135	protein	protein	NN
cord-018265-twp33bb6	551	136	of	of	IN
cord-018265-twp33bb6	551	137	Legionella	Legionella	NNP
cord-018265-twp33bb6	551	138	pneumophila	pneumophila	NN
cord-018265-twp33bb6	551	139	,	,	,
cord-018265-twp33bb6	551	140	a	a	DT
cord-018265-twp33bb6	551	141	genus	genus	NN
cord-018265-twp33bb6	551	142	common	common	JJ
cord-018265-twp33bb6	551	143	antigen	antigen	NN
cord-018265-twp33bb6	551	144	and	and	CC
cord-018265-twp33bb6	551	145	member	member	NN
cord-018265-twp33bb6	551	146	of	of	IN
cord-018265-twp33bb6	551	147	the	the	DT
cord-018265-twp33bb6	551	148	hsp	hsp	NNP
cord-018265-twp33bb6	551	149	60	60	CD
cord-018265-twp33bb6	551	150	family	family	NN
cord-018265-twp33bb6	551	151	of	of	IN
cord-018265-twp33bb6	551	152	heat	heat	NN
cord-018265-twp33bb6	551	153	shock	shock	NN
cord-018265-twp33bb6	551	154	proteins	protein	NNS
cord-018265-twp33bb6	551	155	,	,	,
cord-018265-twp33bb6	551	156	induces	induce	VBZ
cord-018265-twp33bb6	551	157	protective	protective	JJ
cord-018265-twp33bb6	551	158	immunity	immunity	NN
cord-018265-twp33bb6	551	159	in	in	IN
cord-018265-twp33bb6	551	160	a	a	DT
cord-018265-twp33bb6	551	161	guinea	guinea	NN
cord-018265-twp33bb6	551	162	pig	pig	NN
cord-018265-twp33bb6	551	163	model	model	NN
cord-018265-twp33bb6	551	164	of	of	IN
cord-018265-twp33bb6	551	165	Legionnaires	Legionnaires	NNPS
cord-018265-twp33bb6	551	166	'	'	POS
cord-018265-twp33bb6	551	167	disease	disease	NN
cord-018265-twp33bb6	551	168	Comparison	comparison	NN
cord-018265-twp33bb6	551	169	of	of	IN
cord-018265-twp33bb6	551	170	responses	response	NNS
cord-018265-twp33bb6	551	171	elicited	elicit	VBN
cord-018265-twp33bb6	551	172	by	by	IN
cord-018265-twp33bb6	551	173	immunization	immunization	NN
cord-018265-twp33bb6	551	174	with	with	IN
cord-018265-twp33bb6	551	175	a	a	DT
cord-018265-twp33bb6	551	176	Legionella	Legionella	NNP
cord-018265-twp33bb6	551	177	species	specie	NNS
cord-018265-twp33bb6	552	1	common	common	JJ
cord-018265-twp33bb6	552	2	lipoprotein	lipoprotein	NN
cord-018265-twp33bb6	552	3	delivered	deliver	VBN
cord-018265-twp33bb6	552	4	as	as	IN
cord-018265-twp33bb6	552	5	naked	naked	JJ
cord-018265-twp33bb6	552	6	DNA	dna	NN
cord-018265-twp33bb6	552	7	or	or	CC
cord-018265-twp33bb6	552	8	recombinant	recombinant	JJ
cord-018265-twp33bb6	552	9	protein	protein	NN
cord-018265-twp33bb6	552	10	Human	Human	NNP
cord-018265-twp33bb6	552	11	and	and	CC
cord-018265-twp33bb6	552	12	guinea	guinea	NN
cord-018265-twp33bb6	552	13	pig	pig	NN
cord-018265-twp33bb6	552	14	immune	immune	JJ
cord-018265-twp33bb6	552	15	responses	response	NNS
cord-018265-twp33bb6	552	16	to	to	IN
cord-018265-twp33bb6	552	17	Legionella	Legionella	NNP
cord-018265-twp33bb6	552	18	pneumophila	pneumophila	NN
cord-018265-twp33bb6	552	19	protein	protein	NN
cord-018265-twp33bb6	552	20	antigens	antigen	NNS
cord-018265-twp33bb6	552	21	OmpS	OmpS	NNP
cord-018265-twp33bb6	552	22	and	and	CC
cord-018265-twp33bb6	552	23	Hsp60	Hsp60	NNP
cord-018265-twp33bb6	553	1	A	a	DT
cord-018265-twp33bb6	553	2	live	live	JJ
cord-018265-twp33bb6	553	3	avirulent	avirulent	NN
cord-018265-twp33bb6	553	4	mutant	mutant	JJ
cord-018265-twp33bb6	553	5	Legionella	Legionella	NNP
cord-018265-twp33bb6	553	6	pneumophila	pneumophila	NN
cord-018265-twp33bb6	553	7	vaccine	vaccine	NN
cord-018265-twp33bb6	553	8	induces	induce	VBZ
cord-018265-twp33bb6	553	9	protective	protective	JJ
cord-018265-twp33bb6	553	10	immunity	immunity	NN
cord-018265-twp33bb6	553	11	against	against	IN
cord-018265-twp33bb6	553	12	lethal	lethal	JJ
cord-018265-twp33bb6	553	13	aerosol	aerosol	NN
cord-018265-twp33bb6	553	14	challenge	challenge	NN
cord-018265-twp33bb6	553	15	Safety	Safety	NNP
cord-018265-twp33bb6	553	16	and	and	CC
cord-018265-twp33bb6	553	17	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	553	18	of	of	IN
cord-018265-twp33bb6	553	19	a	a	DT
cord-018265-twp33bb6	553	20	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	553	21	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	553	22	O	o	NN
cord-018265-twp33bb6	553	23	-	-	HYPH
cord-018265-twp33bb6	553	24	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	553	25	toxin	toxin	NN
cord-018265-twp33bb6	553	26	A	a	DT
cord-018265-twp33bb6	553	27	conjugate	conjugate	JJ
cord-018265-twp33bb6	553	28	vaccine	vaccine	NN
cord-018265-twp33bb6	553	29	in	in	IN
cord-018265-twp33bb6	553	30	humans	human	NNS
cord-018265-twp33bb6	553	31	Characterization	characterization	NN
cord-018265-twp33bb6	553	32	of	of	IN
cord-018265-twp33bb6	553	33	the	the	DT
cord-018265-twp33bb6	553	34	human	human	JJ
cord-018265-twp33bb6	553	35	immune	immune	JJ
cord-018265-twp33bb6	553	36	response	response	NN
cord-018265-twp33bb6	553	37	to	to	IN
cord-018265-twp33bb6	553	38	a	a	DT
cord-018265-twp33bb6	553	39	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	553	40	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	553	41	O	o	NN
cord-018265-twp33bb6	553	42	-	-	HYPH
cord-018265-twp33bb6	553	43	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	553	44	-	-	HYPH
cord-018265-twp33bb6	553	45	toxin	toxin	NN
cord-018265-twp33bb6	553	46	A	a	DT
cord-018265-twp33bb6	553	47	conjugate	conjugate	JJ
cord-018265-twp33bb6	553	48	vaccine	vaccine	NN
cord-018265-twp33bb6	553	49	Immunization	Immunization	NNP
cord-018265-twp33bb6	553	50	of	of	IN
cord-018265-twp33bb6	553	51	noncolonized	noncolonized	JJ
cord-018265-twp33bb6	553	52	cystic	cystic	JJ
cord-018265-twp33bb6	553	53	fibrosis	fibrosis	NN
cord-018265-twp33bb6	553	54	patients	patient	NNS
cord-018265-twp33bb6	553	55	against	against	IN
cord-018265-twp33bb6	553	56	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	553	57	aeruginosa	aeruginosa	NNP
cord-018265-twp33bb6	553	58	Immunization	Immunization	NNP
cord-018265-twp33bb6	553	59	of	of	IN
cord-018265-twp33bb6	553	60	cystic	cystic	JJ
cord-018265-twp33bb6	553	61	fibrosis	fibrosis	NN
cord-018265-twp33bb6	553	62	patients	patient	NNS
cord-018265-twp33bb6	553	63	with	with	IN
cord-018265-twp33bb6	553	64	a	a	DT
cord-018265-twp33bb6	553	65	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	553	66	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	553	67	O	o	NN
cord-018265-twp33bb6	553	68	-	-	HYPH
cord-018265-twp33bb6	553	69	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	553	70	-	-	HYPH
cord-018265-twp33bb6	553	71	toxin	toxin	NN
cord-018265-twp33bb6	553	72	A	a	DT
cord-018265-twp33bb6	553	73	conjugate	conjugate	JJ
cord-018265-twp33bb6	553	74	vaccine	vaccine	NN
cord-018265-twp33bb6	553	75	Jr	Jr	NNP
cord-018265-twp33bb6	554	1	(	(	-LRB-
cord-018265-twp33bb6	554	2	1991	1991	CD
cord-018265-twp33bb6	554	3	)	)	-RRB-
cord-018265-twp33bb6	554	4	Safety	safety	NN
cord-018265-twp33bb6	554	5	and	and	CC
cord-018265-twp33bb6	554	6	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	554	7	of	of	IN
cord-018265-twp33bb6	554	8	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	554	9	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	554	10	conjugate	conjugate	NNP
cord-018265-twp33bb6	554	11	A	a	DT
cord-018265-twp33bb6	554	12	vaccine	vaccine	NN
cord-018265-twp33bb6	554	13	in	in	IN
cord-018265-twp33bb6	554	14	cystic	cystic	JJ
cord-018265-twp33bb6	554	15	fibrosis	fibrosis	NN
cord-018265-twp33bb6	554	16	Effect	Effect	NNP
cord-018265-twp33bb6	554	17	of	of	IN
cord-018265-twp33bb6	554	18	high	high	JJ
cord-018265-twp33bb6	554	19	-	-	HYPH
cord-018265-twp33bb6	554	20	affinity	affinity	NN
cord-018265-twp33bb6	554	21	anti	anti	JJ
cord-018265-twp33bb6	554	22	-	-	JJ
cord-018265-twp33bb6	554	23	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	554	24	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	554	25	lipopolysaccharide	lipopolysaccharide	NN
cord-018265-twp33bb6	554	26	antibodies	antibody	NNS
cord-018265-twp33bb6	554	27	induced	induce	VBN
cord-018265-twp33bb6	554	28	by	by	IN
cord-018265-twp33bb6	554	29	immunization	immunization	NN
cord-018265-twp33bb6	554	30	on	on	IN
cord-018265-twp33bb6	554	31	the	the	DT
cord-018265-twp33bb6	554	32	rate	rate	NN
cord-018265-twp33bb6	554	33	of	of	IN
cord-018265-twp33bb6	554	34	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	554	35	aeruginosa	aeruginosa	VBZ
cord-018265-twp33bb6	554	36	infection	infection	NN
cord-018265-twp33bb6	554	37	in	in	IN
cord-018265-twp33bb6	554	38	patients	patient	NNS
cord-018265-twp33bb6	554	39	with	with	IN
cord-018265-twp33bb6	554	40	cystic	cystic	JJ
cord-018265-twp33bb6	554	41	fibrosis	fibrosis	NN
cord-018265-twp33bb6	554	42	Vaccination	Vaccination	NNP
cord-018265-twp33bb6	554	43	of	of	IN
cord-018265-twp33bb6	554	44	cystic	cystic	JJ
cord-018265-twp33bb6	554	45	fibrosis	fibrosis	NN
cord-018265-twp33bb6	554	46	patients	patient	NNS
cord-018265-twp33bb6	554	47	against	against	IN
cord-018265-twp33bb6	554	48	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	554	49	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	554	50	reduces	reduce	VBZ
cord-018265-twp33bb6	554	51	the	the	DT
cord-018265-twp33bb6	554	52	proportion	proportion	NN
cord-018265-twp33bb6	554	53	of	of	IN
cord-018265-twp33bb6	554	54	patients	patient	NNS
cord-018265-twp33bb6	554	55	infected	infect	VBN
cord-018265-twp33bb6	554	56	and	and	CC
cord-018265-twp33bb6	554	57	delays	delay	NNS
cord-018265-twp33bb6	554	58	time	time	NN
cord-018265-twp33bb6	554	59	to	to	IN
cord-018265-twp33bb6	554	60	infection	infection	NN
cord-018265-twp33bb6	554	61	Cellular	cellular	JJ
cord-018265-twp33bb6	554	62	immunity	immunity	NN
cord-018265-twp33bb6	554	63	in	in	IN
cord-018265-twp33bb6	554	64	healthy	healthy	JJ
cord-018265-twp33bb6	554	65	volunteers	volunteer	NNS
cord-018265-twp33bb6	554	66	treated	treat	VBN
cord-018265-twp33bb6	554	67	with	with	IN
cord-018265-twp33bb6	554	68	an	an	DT
cord-018265-twp33bb6	554	69	octavalent	octavalent	NN
cord-018265-twp33bb6	554	70	conjugate	conjugate	NN
cord-018265-twp33bb6	554	71	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	554	72	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	554	73	vaccine	vaccine	NN
cord-018265-twp33bb6	554	74	Safety	safety	NN
cord-018265-twp33bb6	554	75	and	and	CC
cord-018265-twp33bb6	554	76	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	554	77	of	of	IN
cord-018265-twp33bb6	554	78	an	an	DT
cord-018265-twp33bb6	554	79	intranasal	intranasal	NN
cord-018265-twp33bb6	554	80	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	554	81	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	554	82	hybrid	hybrid	JJ
cord-018265-twp33bb6	554	83	outer	outer	JJ
cord-018265-twp33bb6	554	84	membrane	membrane	NN
cord-018265-twp33bb6	554	85	protein	protein	NN
cord-018265-twp33bb6	554	86	F	F	NNP
cord-018265-twp33bb6	554	87	-	-	:
cord-018265-twp33bb6	554	88	I	I	NNP
cord-018265-twp33bb6	554	89	vaccine	vaccine	NN
cord-018265-twp33bb6	554	90	in	in	IN
cord-018265-twp33bb6	554	91	human	human	JJ
cord-018265-twp33bb6	554	92	volunteers	volunteer	NNS
cord-018265-twp33bb6	554	93	Mucosal	Mucosal	NNP
cord-018265-twp33bb6	554	94	vaccination	vaccination	NN
cord-018265-twp33bb6	554	95	with	with	IN
cord-018265-twp33bb6	554	96	a	a	DT
cord-018265-twp33bb6	554	97	recombinant	recombinant	JJ
cord-018265-twp33bb6	554	98	OprF	OprF	NNP
cord-018265-twp33bb6	554	99	-	-	:
cord-018265-twp33bb6	554	100	I	-PRON-	PRP
cord-018265-twp33bb6	554	101	vaccine	vaccine	NN
cord-018265-twp33bb6	554	102	of	of	IN
cord-018265-twp33bb6	554	103	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	554	104	aeruginosa	aeruginosa	NN
cord-018265-twp33bb6	554	105	in	in	IN
cord-018265-twp33bb6	554	106	healthy	healthy	JJ
cord-018265-twp33bb6	554	107	volunteers	volunteer	NNS
cord-018265-twp33bb6	554	108	:	:	:
cord-018265-twp33bb6	555	1	comparison	comparison	NN
cord-018265-twp33bb6	555	2	of	of	IN
cord-018265-twp33bb6	555	3	a	a	DT
cord-018265-twp33bb6	555	4	systemic	systemic	JJ
cord-018265-twp33bb6	555	5	vs.	vs.	IN
cord-018265-twp33bb6	555	6	a	a	DT
cord-018265-twp33bb6	555	7	mucosal	mucosal	JJ
cord-018265-twp33bb6	555	8	booster	booster	NN
cord-018265-twp33bb6	555	9	schedule	schedule	NN
cord-018265-twp33bb6	555	10	Application	Application	NNP
cord-018265-twp33bb6	555	11	of	of	IN
cord-018265-twp33bb6	555	12	vaccine	vaccine	NN
cord-018265-twp33bb6	555	13	technology	technology	NN
cord-018265-twp33bb6	555	14	to	to	IN
cord-018265-twp33bb6	555	15	prevention	prevention	NN
cord-018265-twp33bb6	555	16	of	of	IN
cord-018265-twp33bb6	555	17	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	555	18	aeruginosa	aeruginosa	VBZ
cord-018265-twp33bb6	555	19	infections	infection	NNS
cord-018265-twp33bb6	555	20	Vaccines	vaccine	NNS
cord-018265-twp33bb6	555	21	:	:	:
cord-018265-twp33bb6	555	22	past	past	JJ
cord-018265-twp33bb6	555	23	,	,	,
cord-018265-twp33bb6	555	24	present	present	JJ
cord-018265-twp33bb6	555	25	and	and	CC
cord-018265-twp33bb6	555	26	future	future	JJ
cord-018265-twp33bb6	555	27	Six	six	CD
cord-018265-twp33bb6	555	28	revolutions	revolution	NNS
cord-018265-twp33bb6	555	29	in	in	IN
cord-018265-twp33bb6	555	30	vaccinology	vaccinology	NN
cord-018265-twp33bb6	556	1	Can	Can	MD
cord-018265-twp33bb6	556	2	successful	successful	JJ
cord-018265-twp33bb6	556	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	556	4	teach	teach	VB
cord-018265-twp33bb6	556	5	us	-PRON-	PRP
cord-018265-twp33bb6	556	6	how	how	WRB
cord-018265-twp33bb6	556	7	to	to	TO
cord-018265-twp33bb6	556	8	induce	induce	VB
cord-018265-twp33bb6	556	9	efficient	efficient	JJ
cord-018265-twp33bb6	556	10	protective	protective	JJ
cord-018265-twp33bb6	556	11	immune	immune	JJ
cord-018265-twp33bb6	556	12	responses	response	NNS
cord-018265-twp33bb6	556	13	Vaccines	vaccine	NNS
cord-018265-twp33bb6	556	14	,	,	,
cord-018265-twp33bb6	556	15	vaccination	vaccination	NN
cord-018265-twp33bb6	556	16	,	,	,
cord-018265-twp33bb6	556	17	and	and	CC
cord-018265-twp33bb6	556	18	vaccinology	vaccinology	NN
cord-018265-twp33bb6	556	19	Reverse	reverse	VB
cord-018265-twp33bb6	556	20	vaccinology	vaccinology	NN
cord-018265-twp33bb6	556	21	DNA	dna	NN
cord-018265-twp33bb6	556	22	content	content	NN
cord-018265-twp33bb6	556	23	analysis	analysis	NN
cord-018265-twp33bb6	556	24	on	on	IN
cord-018265-twp33bb6	556	25	microarrays	microarray	NNS
cord-018265-twp33bb6	556	26	Immunoinformatics	Immunoinformatics	NNP
cord-018265-twp33bb6	556	27	:	:	:
cord-018265-twp33bb6	556	28	Mining	mining	NN
cord-018265-twp33bb6	556	29	genomes	genome	NNS
cord-018265-twp33bb6	556	30	for	for	IN
cord-018265-twp33bb6	556	31	vaccine	vaccine	NN
cord-018265-twp33bb6	556	32	components	component	NNS
cord-018265-twp33bb6	557	1	The	the	DT
cord-018265-twp33bb6	557	2	development	development	NN
cord-018265-twp33bb6	557	3	of	of	IN
cord-018265-twp33bb6	557	4	multi	multi	JJ
cord-018265-twp33bb6	557	5	-	-	JJ
cord-018265-twp33bb6	557	6	epitope	epitope	JJ
cord-018265-twp33bb6	557	7	vaccines	vaccine	NNS
cord-018265-twp33bb6	557	8	:	:	:
cord-018265-twp33bb6	557	9	epitope	epitope	NN
cord-018265-twp33bb6	557	10	identification	identification	NN
cord-018265-twp33bb6	557	11	,	,	,
cord-018265-twp33bb6	557	12	vaccine	vaccine	NN
cord-018265-twp33bb6	557	13	design	design	NN
cord-018265-twp33bb6	557	14	and	and	CC
cord-018265-twp33bb6	557	15	clinical	clinical	JJ
cord-018265-twp33bb6	557	16	evaluation	evaluation	NN
cord-018265-twp33bb6	558	1	Reverse	reverse	JJ
cord-018265-twp33bb6	558	2	vaccinology	vaccinology	NN
cord-018265-twp33bb6	558	3	and	and	CC
cord-018265-twp33bb6	558	4	genomics	genomic	NNS
cord-018265-twp33bb6	559	1	Reverse	reverse	JJ
cord-018265-twp33bb6	559	2	vaccinology	vaccinology	NN
cord-018265-twp33bb6	560	1	A	a	DT
cord-018265-twp33bb6	560	2	new	new	JJ
cord-018265-twp33bb6	560	3	approach	approach	NN
cord-018265-twp33bb6	560	4	to	to	IN
cord-018265-twp33bb6	560	5	an	an	DT
cord-018265-twp33bb6	560	6	influenza	influenza	NN
cord-018265-twp33bb6	560	7	live	live	JJ
cord-018265-twp33bb6	560	8	vaccine	vaccine	NN
cord-018265-twp33bb6	560	9	:	:	:
cord-018265-twp33bb6	560	10	modification	modification	NN
cord-018265-twp33bb6	560	11	of	of	IN
cord-018265-twp33bb6	560	12	the	the	DT
cord-018265-twp33bb6	560	13	cleavage	cleavage	NN
cord-018265-twp33bb6	560	14	site	site	NN
cord-018265-twp33bb6	560	15	of	of	IN
cord-018265-twp33bb6	560	16	hemagglutinin	hemagglutinin	NN
cord-018265-twp33bb6	560	17	Generation	generation	NN
cord-018265-twp33bb6	560	18	of	of	IN
cord-018265-twp33bb6	560	19	high	high	RB
cord-018265-twp33bb6	560	20	-	-	HYPH
cord-018265-twp33bb6	560	21	yielding	yield	VBG
cord-018265-twp33bb6	560	22	influenza	influenza	NN
cord-018265-twp33bb6	560	23	A	a	DT
cord-018265-twp33bb6	560	24	viruses	virus	NNS
cord-018265-twp33bb6	560	25	in	in	IN
cord-018265-twp33bb6	560	26	African	african	JJ
cord-018265-twp33bb6	560	27	green	green	JJ
cord-018265-twp33bb6	560	28	monkey	monkey	NN
cord-018265-twp33bb6	560	29	kidney	kidney	NN
cord-018265-twp33bb6	560	30	(	(	-LRB-
cord-018265-twp33bb6	560	31	Vero	Vero	NNP
cord-018265-twp33bb6	560	32	)	)	-RRB-
cord-018265-twp33bb6	560	33	cells	cell	NNS
cord-018265-twp33bb6	560	34	by	by	IN
cord-018265-twp33bb6	560	35	reverse	reverse	JJ
cord-018265-twp33bb6	560	36	genetics	genetic	NNS
cord-018265-twp33bb6	560	37	From	from	IN
cord-018265-twp33bb6	560	38	lethal	lethal	JJ
cord-018265-twp33bb6	560	39	virus	virus	NN
cord-018265-twp33bb6	560	40	to	to	IN
cord-018265-twp33bb6	560	41	life	life	NN
cord-018265-twp33bb6	560	42	-	-	HYPH
cord-018265-twp33bb6	560	43	saving	save	VBG
cord-018265-twp33bb6	560	44	vaccine	vaccine	NN
cord-018265-twp33bb6	560	45	:	:	:
cord-018265-twp33bb6	560	46	developing	develop	VBG
cord-018265-twp33bb6	560	47	inactivated	inactivate	VBN
cord-018265-twp33bb6	560	48	vaccines	vaccine	NNS
cord-018265-twp33bb6	560	49	for	for	IN
cord-018265-twp33bb6	560	50	pandemic	pandemic	NN
cord-018265-twp33bb6	560	51	influenza	influenza	NN
cord-018265-twp33bb6	560	52	Influenza	Influenza	NNP
cord-018265-twp33bb6	560	53	vaccines	vaccine	NNS
cord-018265-twp33bb6	560	54	generated	generate	VBN
cord-018265-twp33bb6	560	55	by	by	IN
cord-018265-twp33bb6	560	56	reverse	reverse	JJ
cord-018265-twp33bb6	560	57	genetics	genetic	NNS
cord-018265-twp33bb6	560	58	Influenza	influenza	NN
cord-018265-twp33bb6	560	59	:	:	:
cord-018265-twp33bb6	560	60	girding	gird	VBG
cord-018265-twp33bb6	560	61	for	for	IN
cord-018265-twp33bb6	560	62	disaster	disaster	NN
cord-018265-twp33bb6	560	63	.	.	.
cord-018265-twp33bb6	561	1	Facing	face	VBG
cord-018265-twp33bb6	561	2	down	down	RP
cord-018265-twp33bb6	561	3	pandemic	pandemic	NN
cord-018265-twp33bb6	561	4	flu	flu	NN
cord-018265-twp33bb6	561	5	,	,	,
cord-018265-twp33bb6	561	6	the	the	DT
cord-018265-twp33bb6	561	7	world	world	NN
cord-018265-twp33bb6	561	8	's	's	POS
cord-018265-twp33bb6	561	9	defenses	defense	NNS
cord-018265-twp33bb6	561	10	are	be	VBP
cord-018265-twp33bb6	561	11	weak	weak	JJ
cord-018265-twp33bb6	561	12	Mucosal	Mucosal	NNP
cord-018265-twp33bb6	561	13	immunity	immunity	NN
cord-018265-twp33bb6	561	14	and	and	CC
cord-018265-twp33bb6	561	15	vaccines	vaccine	NNS
cord-018265-twp33bb6	561	16	Bacteria	Bacteria	NNS
cord-018265-twp33bb6	561	17	as	as	IN
cord-018265-twp33bb6	561	18	DNA	dna	NN
cord-018265-twp33bb6	561	19	vaccine	vaccine	NN
cord-018265-twp33bb6	561	20	carriers	carrier	NNS
cord-018265-twp33bb6	561	21	for	for	IN
cord-018265-twp33bb6	561	22	genetic	genetic	JJ
cord-018265-twp33bb6	561	23	immunization	immunization	NN
cord-018265-twp33bb6	561	24	Mucosal	Mucosal	NNP
cord-018265-twp33bb6	561	25	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	561	26	and	and	CC
cord-018265-twp33bb6	561	27	delivery	delivery	NN
cord-018265-twp33bb6	561	28	systems	system	NNS
cord-018265-twp33bb6	561	29	for	for	IN
cord-018265-twp33bb6	561	30	protein-	protein-	JJ
cord-018265-twp33bb6	561	31	,	,	,
cord-018265-twp33bb6	561	32	DNA	dna	NN
cord-018265-twp33bb6	561	33	-	-	:
cord-018265-twp33bb6	561	34	and	and	CC
cord-018265-twp33bb6	561	35	RNA	RNA	NNP
cord-018265-twp33bb6	561	36	-	-	HYPH
cord-018265-twp33bb6	561	37	based	base	VBN
cord-018265-twp33bb6	561	38	vaccines	vaccine	NNS
cord-018265-twp33bb6	561	39	A	a	DT
cord-018265-twp33bb6	561	40	novel	novel	JJ
cord-018265-twp33bb6	561	41	recombinant	recombinant	JJ
cord-018265-twp33bb6	561	42	multisubunit	multisubunit	NN
cord-018265-twp33bb6	561	43	vaccine	vaccine	NN
cord-018265-twp33bb6	561	44	against	against	IN
cord-018265-twp33bb6	561	45	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	561	46	Poly(lactideco	poly(lactideco	NN
cord-018265-twp33bb6	561	47	-	-	HYPH
cord-018265-twp33bb6	561	48	glycolide	glycolide	NNP
cord-018265-twp33bb6	561	49	)	)	-RRB-
cord-018265-twp33bb6	561	50	microencapsulation	microencapsulation	NN
cord-018265-twp33bb6	561	51	of	of	IN
cord-018265-twp33bb6	561	52	vaccines	vaccine	NNS
cord-018265-twp33bb6	561	53	for	for	IN
cord-018265-twp33bb6	561	54	mucosal	mucosal	JJ
cord-018265-twp33bb6	561	55	immunization	immunization	NN
cord-018265-twp33bb6	561	56	ISCOMs	iscom	NNS
cord-018265-twp33bb6	561	57	,	,	,
cord-018265-twp33bb6	561	58	liposomes	liposome	NNS
cord-018265-twp33bb6	561	59	,	,	,
cord-018265-twp33bb6	561	60	and	and	CC
cord-018265-twp33bb6	561	61	oil	oil	NN
cord-018265-twp33bb6	561	62	-	-	HYPH
cord-018265-twp33bb6	561	63	based	base	VBN
cord-018265-twp33bb6	561	64	vaccine	vaccine	NN
cord-018265-twp33bb6	561	65	delivery	delivery	NN
cord-018265-twp33bb6	561	66	systems	system	NNS
cord-018265-twp33bb6	561	67	Lipid	Lipid	NNP
cord-018265-twp33bb6	561	68	based	base	VBN
cord-018265-twp33bb6	561	69	particulate	particulate	NN
cord-018265-twp33bb6	561	70	formulations	formulation	NNS
cord-018265-twp33bb6	561	71	for	for	IN
cord-018265-twp33bb6	561	72	the	the	DT
cord-018265-twp33bb6	561	73	delivery	delivery	NN
cord-018265-twp33bb6	561	74	of	of	IN
cord-018265-twp33bb6	561	75	antigen	antigen	NNP
cord-018265-twp33bb6	561	76	Cross	Cross	NNP
cord-018265-twp33bb6	561	77	-	-	JJ
cord-018265-twp33bb6	561	78	protective	protective	JJ
cord-018265-twp33bb6	561	79	immunity	immunity	NN
cord-018265-twp33bb6	561	80	of	of	IN
cord-018265-twp33bb6	561	81	mice	mouse	NNS
cord-018265-twp33bb6	561	82	induced	induce	VBN
cord-018265-twp33bb6	561	83	by	by	IN
cord-018265-twp33bb6	561	84	oral	oral	JJ
cord-018265-twp33bb6	561	85	immunization	immunization	NN
cord-018265-twp33bb6	561	86	with	with	IN
cord-018265-twp33bb6	561	87	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	561	88	surface	surface	NN
cord-018265-twp33bb6	561	89	adhesin	adhesin	NNP
cord-018265-twp33bb6	561	90	a	a	DT
cord-018265-twp33bb6	561	91	encapsulated	encapsulate	VBN
cord-018265-twp33bb6	561	92	in	in	IN
cord-018265-twp33bb6	561	93	microspheres	microsphere	NNS
cord-018265-twp33bb6	561	94	Protection	Protection	NNP
cord-018265-twp33bb6	561	95	of	of	IN
cord-018265-twp33bb6	561	96	mice	mouse	NNS
cord-018265-twp33bb6	561	97	against	against	IN
cord-018265-twp33bb6	561	98	lethal	lethal	JJ
cord-018265-twp33bb6	561	99	infection	infection	NN
cord-018265-twp33bb6	561	100	with	with	IN
cord-018265-twp33bb6	561	101	highly	highly	RB
cord-018265-twp33bb6	561	102	pathogenic	pathogenic	JJ
cord-018265-twp33bb6	561	103	H7N7	H7N7	NNP
cord-018265-twp33bb6	561	104	influenza	influenza	NN
cord-018265-twp33bb6	561	105	A	a	DT
cord-018265-twp33bb6	561	106	virus	virus	NN
cord-018265-twp33bb6	561	107	by	by	IN
cord-018265-twp33bb6	561	108	using	use	VBG
cord-018265-twp33bb6	561	109	a	a	DT
cord-018265-twp33bb6	561	110	recombinant	recombinant	JJ
cord-018265-twp33bb6	561	111	low	low	JJ
cord-018265-twp33bb6	561	112	-	-	HYPH
cord-018265-twp33bb6	561	113	pathogenicity	pathogenicity	NN
cord-018265-twp33bb6	561	114	vaccine	vaccine	NN
cord-018265-twp33bb6	561	115	strain	strain	NN
cord-018265-twp33bb6	561	116	Enhanced	enhance	VBN
cord-018265-twp33bb6	561	117	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	561	118	in	in	IN
cord-018265-twp33bb6	561	119	the	the	DT
cord-018265-twp33bb6	561	120	murine	murine	JJ
cord-018265-twp33bb6	561	121	airway	airway	NN
cord-018265-twp33bb6	561	122	mucosa	mucosa	NN
cord-018265-twp33bb6	561	123	with	with	IN
cord-018265-twp33bb6	561	124	an	an	DT
cord-018265-twp33bb6	561	125	attenuated	attenuated	JJ
cord-018265-twp33bb6	561	126	Salmonella	Salmonella	NNP
cord-018265-twp33bb6	561	127	live	live	JJ
cord-018265-twp33bb6	561	128	vaccine	vaccine	NN
cord-018265-twp33bb6	561	129	expressing	express	VBG
cord-018265-twp33bb6	561	130	OprF	OprF	NNP
cord-018265-twp33bb6	561	131	-	-	HYPH
cord-018265-twp33bb6	561	132	OprI	OprI	NNP
cord-018265-twp33bb6	561	133	from	from	IN
cord-018265-twp33bb6	561	134	Pseudomonas	Pseudomonas	NNP
cord-018265-twp33bb6	561	135	aeruginosa	aeruginosa	VBZ
cord-018265-twp33bb6	561	136	Protective	Protective	NNP
cord-018265-twp33bb6	561	137	humoral	humoral	JJ
cord-018265-twp33bb6	561	138	response	response	NN
cord-018265-twp33bb6	561	139	against	against	IN
cord-018265-twp33bb6	561	140	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	561	141	infection	infection	NN
cord-018265-twp33bb6	561	142	in	in	IN
cord-018265-twp33bb6	561	143	mice	mouse	NNS
cord-018265-twp33bb6	561	144	elicited	elicit	VBN
cord-018265-twp33bb6	561	145	by	by	IN
cord-018265-twp33bb6	561	146	recombinant	recombinant	JJ
cord-018265-twp33bb6	561	147	bacille	bacille	NNP
cord-018265-twp33bb6	561	148	Calmette	Calmette	NNP
cord-018265-twp33bb6	561	149	-	-	HYPH
cord-018265-twp33bb6	561	150	Guerin	Guerin	NNP
cord-018265-twp33bb6	561	151	vaccines	vaccine	NNS
cord-018265-twp33bb6	561	152	expressing	express	VBG
cord-018265-twp33bb6	561	153	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	561	154	surface	surface	NN
cord-018265-twp33bb6	561	155	protein	protein	NN
cord-018265-twp33bb6	561	156	A	a	DT
cord-018265-twp33bb6	561	157	Intragastric	Intragastric	NNP
cord-018265-twp33bb6	561	158	administration	administration	NN
cord-018265-twp33bb6	561	159	of	of	IN
cord-018265-twp33bb6	561	160	Lactobacillus	Lactobacillus	NNP
cord-018265-twp33bb6	561	161	casei	casei	NN
cord-018265-twp33bb6	561	162	expressing	express	VBG
cord-018265-twp33bb6	561	163	transmissible	transmissible	JJ
cord-018265-twp33bb6	561	164	gastroentritis	gastroentritis	NN
cord-018265-twp33bb6	561	165	coronavirus	coronavirus	NN
cord-018265-twp33bb6	561	166	spike	spike	NN
cord-018265-twp33bb6	561	167	glycoprotein	glycoprotein	NN
cord-018265-twp33bb6	561	168	induced	induce	VBD
cord-018265-twp33bb6	561	169	specific	specific	JJ
cord-018265-twp33bb6	561	170	antibody	antibody	NN
cord-018265-twp33bb6	561	171	production	production	NN
cord-018265-twp33bb6	561	172	Expression	expression	NN
cord-018265-twp33bb6	561	173	of	of	IN
cord-018265-twp33bb6	561	174	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	561	175	psittaci	psittaci	NN
cord-018265-twp33bb6	561	176	-	-	HYPH
cord-018265-twp33bb6	561	177	and	and	CC
cord-018265-twp33bb6	561	178	human	human	JJ
cord-018265-twp33bb6	561	179	immunodeficiency	immunodeficiency	NN
cord-018265-twp33bb6	561	180	virus	virus	NN
cord-018265-twp33bb6	561	181	-	-	HYPH
cord-018265-twp33bb6	561	182	derived	derive	VBN
cord-018265-twp33bb6	561	183	antigens	antigen	NNS
cord-018265-twp33bb6	561	184	on	on	IN
cord-018265-twp33bb6	561	185	the	the	DT
cord-018265-twp33bb6	561	186	cell	cell	NN
cord-018265-twp33bb6	561	187	surface	surface	NN
cord-018265-twp33bb6	561	188	of	of	IN
cord-018265-twp33bb6	561	189	Lactobacillus	lactobacillus	NN
cord-018265-twp33bb6	561	190	fermentum	fermentum	NN
cord-018265-twp33bb6	561	191	BR11	BR11	NNP
cord-018265-twp33bb6	561	192	as	as	IN
cord-018265-twp33bb6	561	193	fusions	fusion	NNS
cord-018265-twp33bb6	561	194	to	to	IN
cord-018265-twp33bb6	561	195	bspA	bspa	VB
cord-018265-twp33bb6	561	196	Jr	Jr	NNP
cord-018265-twp33bb6	561	197	(	(	-LRB-
cord-018265-twp33bb6	561	198	1996	1996	CD
cord-018265-twp33bb6	561	199	)	)	-RRB-
cord-018265-twp33bb6	562	1	Oral	oral	JJ
cord-018265-twp33bb6	562	2	immunization	immunization	NN
cord-018265-twp33bb6	562	3	with	with	IN
cord-018265-twp33bb6	562	4	a	a	DT
cord-018265-twp33bb6	562	5	replication	replication	NN
cord-018265-twp33bb6	562	6	-	-	HYPH
cord-018265-twp33bb6	562	7	deficient	deficient	JJ
cord-018265-twp33bb6	562	8	recombinant	recombinant	JJ
cord-018265-twp33bb6	562	9	vaccinia	vaccinia	NN
cord-018265-twp33bb6	562	10	virus	virus	NN
cord-018265-twp33bb6	562	11	protects	protect	VBZ
cord-018265-twp33bb6	562	12	mice	mouse	NNS
cord-018265-twp33bb6	562	13	against	against	IN
cord-018265-twp33bb6	562	14	influenza	influenza	NN
cord-018265-twp33bb6	562	15	Evaluation	Evaluation	NNP
cord-018265-twp33bb6	562	16	of	of	IN
cord-018265-twp33bb6	562	17	modified	modify	VBN
cord-018265-twp33bb6	562	18	vaccinia	vaccinia	NN
cord-018265-twp33bb6	562	19	virus	virus	NN
cord-018265-twp33bb6	562	20	Ankara	Ankara	NNP
cord-018265-twp33bb6	562	21	based	base	VBN
cord-018265-twp33bb6	562	22	recombinant	recombinant	JJ
cord-018265-twp33bb6	562	23	SARS	SARS	NNP
cord-018265-twp33bb6	562	24	vaccine	vaccine	NN
cord-018265-twp33bb6	562	25	in	in	IN
cord-018265-twp33bb6	562	26	ferrets	ferret	NNS
cord-018265-twp33bb6	562	27	New	new	JJ
cord-018265-twp33bb6	562	28	strategies	strategy	NNS
cord-018265-twp33bb6	562	29	for	for	IN
cord-018265-twp33bb6	562	30	combination	combination	NN
cord-018265-twp33bb6	562	31	vaccines	vaccine	NNS
cord-018265-twp33bb6	562	32	based	base	VBN
cord-018265-twp33bb6	562	33	on	on	IN
cord-018265-twp33bb6	562	34	the	the	DT
cord-018265-twp33bb6	562	35	extended	extended	JJ
cord-018265-twp33bb6	562	36	recombinant	recombinant	JJ
cord-018265-twp33bb6	562	37	bacterial	bacterial	JJ
cord-018265-twp33bb6	562	38	ghost	ghost	NN
cord-018265-twp33bb6	562	39	system	system	NN
cord-018265-twp33bb6	562	40	Online	Online	NNP
cord-018265-twp33bb6	562	41	monitoring	monitoring	NN
cord-018265-twp33bb6	562	42	of	of	IN
cord-018265-twp33bb6	562	43	Escherichia	Escherichia	NNP
cord-018265-twp33bb6	562	44	coli	coli	NNS
cord-018265-twp33bb6	562	45	ghost	ghost	NN
cord-018265-twp33bb6	562	46	production	production	NN
cord-018265-twp33bb6	562	47	Extended	extend	VBN
cord-018265-twp33bb6	562	48	recombinant	recombinant	JJ
cord-018265-twp33bb6	562	49	bacterial	bacterial	JJ
cord-018265-twp33bb6	562	50	ghost	ghost	NN
cord-018265-twp33bb6	562	51	system	system	NN
cord-018265-twp33bb6	562	52	Bacterial	bacterial	JJ
cord-018265-twp33bb6	562	53	ghosts	ghost	NNS
cord-018265-twp33bb6	562	54	as	as	IN
cord-018265-twp33bb6	562	55	carrier	carrier	NN
cord-018265-twp33bb6	562	56	and	and	CC
cord-018265-twp33bb6	562	57	targeting	target	VBG
cord-018265-twp33bb6	562	58	systems	system	NNS
cord-018265-twp33bb6	562	59	Bacterial	bacterial	JJ
cord-018265-twp33bb6	562	60	ghosts	ghost	NNS
cord-018265-twp33bb6	562	61	as	as	IN
cord-018265-twp33bb6	562	62	multifunctional	multifunctional	JJ
cord-018265-twp33bb6	562	63	vaccine	vaccine	NN
cord-018265-twp33bb6	562	64	particles	particle	NNS
cord-018265-twp33bb6	562	65	Dynamics	dynamic	NNS
cord-018265-twp33bb6	562	66	of	of	IN
cord-018265-twp33bb6	562	67	PhiX174	PhiX174	NNP
cord-018265-twp33bb6	562	68	protein	protein	NN
cord-018265-twp33bb6	562	69	E	e	NN
cord-018265-twp33bb6	562	70	-	-	HYPH
cord-018265-twp33bb6	562	71	mediated	mediate	VBN
cord-018265-twp33bb6	562	72	lysis	lysis	NN
cord-018265-twp33bb6	562	73	of	of	IN
cord-018265-twp33bb6	562	74	Escherichia	Escherichia	NNP
cord-018265-twp33bb6	562	75	coli	coli	NNS
cord-018265-twp33bb6	563	1	The	the	DT
cord-018265-twp33bb6	563	2	danger	danger	NN
cord-018265-twp33bb6	563	3	model	model	NN
cord-018265-twp33bb6	563	4	:	:	:
cord-018265-twp33bb6	563	5	a	a	DT
cord-018265-twp33bb6	563	6	renewed	renew	VBN
cord-018265-twp33bb6	563	7	sense	sense	NN
cord-018265-twp33bb6	563	8	of	of	IN
cord-018265-twp33bb6	563	9	self	self	NN
cord-018265-twp33bb6	563	10	Endotoxicity	Endotoxicity	NNP
cord-018265-twp33bb6	563	11	does	do	VBZ
cord-018265-twp33bb6	563	12	not	not	RB
cord-018265-twp33bb6	563	13	limit	limit	VB
cord-018265-twp33bb6	563	14	the	the	DT
cord-018265-twp33bb6	563	15	use	use	NN
cord-018265-twp33bb6	563	16	of	of	IN
cord-018265-twp33bb6	563	17	bacterial	bacterial	JJ
cord-018265-twp33bb6	563	18	ghosts	ghost	NNS
cord-018265-twp33bb6	563	19	as	as	IN
cord-018265-twp33bb6	563	20	candidate	candidate	NN
cord-018265-twp33bb6	563	21	vaccines	vaccine	NNS
cord-018265-twp33bb6	563	22	Delivery	Delivery	NNP
cord-018265-twp33bb6	563	23	of	of	IN
cord-018265-twp33bb6	563	24	Chlamydia	Chlamydia	NNP
cord-018265-twp33bb6	563	25	vaccines	vaccine	NNS
cord-018265-twp33bb6	563	26	Virus	virus	NN
cord-018265-twp33bb6	563	27	-	-	HYPH
cord-018265-twp33bb6	563	28	like	like	JJ
cord-018265-twp33bb6	563	29	particles	particle	NNS
cord-018265-twp33bb6	563	30	as	as	IN
cord-018265-twp33bb6	563	31	vaccines	vaccine	NNS
cord-018265-twp33bb6	563	32	and	and	CC
cord-018265-twp33bb6	563	33	vessels	vessel	NNS
cord-018265-twp33bb6	563	34	for	for	IN
cord-018265-twp33bb6	563	35	the	the	DT
cord-018265-twp33bb6	563	36	delivery	delivery	NN
cord-018265-twp33bb6	563	37	of	of	IN
cord-018265-twp33bb6	563	38	small	small	JJ
cord-018265-twp33bb6	563	39	molecules	molecule	NNS
cord-018265-twp33bb6	563	40	Recombinant	Recombinant	NNP
cord-018265-twp33bb6	563	41	Norwalk	Norwalk	NNP
cord-018265-twp33bb6	563	42	virus	virus	NN
cord-018265-twp33bb6	563	43	-	-	HYPH
cord-018265-twp33bb6	563	44	like	like	JJ
cord-018265-twp33bb6	563	45	particles	particle	NNS
cord-018265-twp33bb6	563	46	administered	administer	VBN
cord-018265-twp33bb6	563	47	intranasally	intranasally	RB
cord-018265-twp33bb6	563	48	to	to	IN
cord-018265-twp33bb6	563	49	mice	mouse	NNS
cord-018265-twp33bb6	563	50	induce	induce	VBP
cord-018265-twp33bb6	563	51	systemic	systemic	JJ
cord-018265-twp33bb6	563	52	and	and	CC
cord-018265-twp33bb6	563	53	mucosal	mucosal	JJ
cord-018265-twp33bb6	563	54	(	(	-LRB-
cord-018265-twp33bb6	563	55	fecal	fecal	JJ
cord-018265-twp33bb6	563	56	and	and	CC
cord-018265-twp33bb6	563	57	vaginal	vaginal	JJ
cord-018265-twp33bb6	563	58	)	)	-RRB-
cord-018265-twp33bb6	563	59	immune	immune	JJ
cord-018265-twp33bb6	563	60	responses	response	NNS
cord-018265-twp33bb6	563	61	Chimeric	chimeric	JJ
cord-018265-twp33bb6	563	62	recombinant	recombinant	JJ
cord-018265-twp33bb6	563	63	hepatitis	hepatitis	NN
cord-018265-twp33bb6	563	64	E	e	NN
cord-018265-twp33bb6	563	65	virus	virus	NN
cord-018265-twp33bb6	563	66	-	-	HYPH
cord-018265-twp33bb6	563	67	like	like	JJ
cord-018265-twp33bb6	563	68	particles	particle	NNS
cord-018265-twp33bb6	563	69	as	as	IN
cord-018265-twp33bb6	563	70	an	an	DT
cord-018265-twp33bb6	563	71	oral	oral	JJ
cord-018265-twp33bb6	563	72	vaccine	vaccine	NN
cord-018265-twp33bb6	563	73	vehicle	vehicle	NN
cord-018265-twp33bb6	563	74	presenting	present	VBG
cord-018265-twp33bb6	563	75	foreign	foreign	JJ
cord-018265-twp33bb6	563	76	epitopes	epitope	NNS
cord-018265-twp33bb6	563	77	Papillomavirus	Papillomavirus	NNP
cord-018265-twp33bb6	563	78	pseudovirus	pseudovirus	NNP
cord-018265-twp33bb6	563	79	:	:	:
cord-018265-twp33bb6	563	80	a	a	DT
cord-018265-twp33bb6	563	81	novel	novel	JJ
cord-018265-twp33bb6	563	82	vaccine	vaccine	NN
cord-018265-twp33bb6	563	83	to	to	TO
cord-018265-twp33bb6	563	84	induce	induce	VB
cord-018265-twp33bb6	563	85	mucosal	mucosal	JJ
cord-018265-twp33bb6	563	86	and	and	CC
cord-018265-twp33bb6	563	87	systemic	systemic	JJ
cord-018265-twp33bb6	563	88	cytotoxic	cytotoxic	JJ
cord-018265-twp33bb6	563	89	T	t	NN
cord-018265-twp33bb6	563	90	-	-	HYPH
cord-018265-twp33bb6	563	91	lymphocyte	lymphocyte	NN
cord-018265-twp33bb6	563	92	responses	response	NNS
cord-018265-twp33bb6	563	93	Induction	Induction	NNP
cord-018265-twp33bb6	563	94	of	of	IN
cord-018265-twp33bb6	563	95	cytotoxic	cytotoxic	JJ
cord-018265-twp33bb6	563	96	T	t	NN
cord-018265-twp33bb6	563	97	lymphocyte	lymphocyte	NN
cord-018265-twp33bb6	563	98	activity	activity	NN
cord-018265-twp33bb6	563	99	by	by	IN
cord-018265-twp33bb6	563	100	fusion	fusion	NN
cord-018265-twp33bb6	563	101	-	-	HYPH
cord-018265-twp33bb6	563	102	active	active	JJ
cord-018265-twp33bb6	563	103	peptide	peptide	NN
cord-018265-twp33bb6	563	104	-	-	HYPH
cord-018265-twp33bb6	563	105	containing	contain	VBG
cord-018265-twp33bb6	563	106	virosomes	virosome	NNS
cord-018265-twp33bb6	563	107	Delivery	Delivery	NNP
cord-018265-twp33bb6	563	108	of	of	IN
cord-018265-twp33bb6	563	109	protein	protein	NN
cord-018265-twp33bb6	563	110	antigens	antigen	NNS
cord-018265-twp33bb6	563	111	to	to	IN
cord-018265-twp33bb6	563	112	the	the	DT
cord-018265-twp33bb6	563	113	immune	immune	JJ
cord-018265-twp33bb6	563	114	system	system	NN
cord-018265-twp33bb6	563	115	by	by	IN
cord-018265-twp33bb6	563	116	fusion	fusion	NN
cord-018265-twp33bb6	563	117	-	-	HYPH
cord-018265-twp33bb6	563	118	active	active	JJ
cord-018265-twp33bb6	563	119	virosomes	virosomes	NN
cord-018265-twp33bb6	563	120	:	:	:
cord-018265-twp33bb6	563	121	a	a	DT
cord-018265-twp33bb6	563	122	comparison	comparison	NN
cord-018265-twp33bb6	563	123	with	with	IN
cord-018265-twp33bb6	563	124	liposomes	liposome	NNS
cord-018265-twp33bb6	563	125	and	and	CC
cord-018265-twp33bb6	563	126	ISCOMs	ISCOMs	NNPS
cord-018265-twp33bb6	563	127	Virosomes	Virosomes	NNP
cord-018265-twp33bb6	563	128	in	in	IN
cord-018265-twp33bb6	563	129	vaccine	vaccine	NN
cord-018265-twp33bb6	563	130	development	development	NN
cord-018265-twp33bb6	563	131	:	:	:
cord-018265-twp33bb6	563	132	induction	induction	NN
cord-018265-twp33bb6	563	133	of	of	IN
cord-018265-twp33bb6	563	134	cytotoxic	cytotoxic	JJ
cord-018265-twp33bb6	563	135	T	t	NN
cord-018265-twp33bb6	563	136	lymphocyte	lymphocyte	NN
cord-018265-twp33bb6	563	137	activity	activity	NN
cord-018265-twp33bb6	563	138	with	with	IN
cord-018265-twp33bb6	563	139	virosome	virosome	NN
cord-018265-twp33bb6	563	140	-	-	HYPH
cord-018265-twp33bb6	563	141	encapsulated	encapsulate	VBN
cord-018265-twp33bb6	563	142	protein	protein	NN
cord-018265-twp33bb6	563	143	antigens	antigen	NNS
cord-018265-twp33bb6	563	144	Modulation	modulation	NN
cord-018265-twp33bb6	563	145	of	of	IN
cord-018265-twp33bb6	563	146	the	the	DT
cord-018265-twp33bb6	563	147	immune	immune	JJ
cord-018265-twp33bb6	563	148	response	response	NN
cord-018265-twp33bb6	563	149	by	by	IN
cord-018265-twp33bb6	563	150	the	the	DT
cord-018265-twp33bb6	563	151	cholera	cholera	NN
cord-018265-twp33bb6	563	152	-	-	HYPH
cord-018265-twp33bb6	563	153	like	like	JJ
cord-018265-twp33bb6	563	154	enterotoxins	enterotoxin	NNS
cord-018265-twp33bb6	563	155	Mucosal	Mucosal	NNP
cord-018265-twp33bb6	563	156	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	563	157	and	and	CC
cord-018265-twp33bb6	563	158	anti	anti	JJ
cord-018265-twp33bb6	563	159	-	-	JJ
cord-018265-twp33bb6	563	160	infection	infection	JJ
cord-018265-twp33bb6	563	161	and	and	CC
cord-018265-twp33bb6	563	162	anti	anti	JJ
cord-018265-twp33bb6	563	163	-	-	JJ
cord-018265-twp33bb6	563	164	immunopathology	immunopathology	JJ
cord-018265-twp33bb6	563	165	vaccines	vaccine	NNS
cord-018265-twp33bb6	563	166	based	base	VBN
cord-018265-twp33bb6	563	167	on	on	IN
cord-018265-twp33bb6	563	168	cholera	cholera	NN
cord-018265-twp33bb6	563	169	toxin	toxin	NN
cord-018265-twp33bb6	563	170	,	,	,
cord-018265-twp33bb6	563	171	cholera	cholera	NN
cord-018265-twp33bb6	563	172	toxin	toxin	NN
cord-018265-twp33bb6	563	173	B	B	NNP
cord-018265-twp33bb6	563	174	subunit	subunit	NN
cord-018265-twp33bb6	563	175	and	and	CC
cord-018265-twp33bb6	563	176	CpG	CpG	NNP
cord-018265-twp33bb6	563	177	DNA	DNA	NNP
cord-018265-twp33bb6	563	178	New	New	NNP
cord-018265-twp33bb6	563	179	generation	generation	NN
cord-018265-twp33bb6	563	180	of	of	IN
cord-018265-twp33bb6	563	181	immune	immune	JJ
cord-018265-twp33bb6	563	182	modulators	modulator	NNS
cord-018265-twp33bb6	563	183	based	base	VBN
cord-018265-twp33bb6	563	184	on	on	IN
cord-018265-twp33bb6	563	185	Toll	Toll	NNP
cord-018265-twp33bb6	563	186	-	-	HYPH
cord-018265-twp33bb6	563	187	like	like	JJ
cord-018265-twp33bb6	563	188	receptors	receptor	NNS
cord-018265-twp33bb6	563	189	signaling	signal	VBG
cord-018265-twp33bb6	563	190	Mucosal	Mucosal	NNP
cord-018265-twp33bb6	563	191	vaccines	vaccine	NNS
cord-018265-twp33bb6	563	192	:	:	:
cord-018265-twp33bb6	563	193	non	non	JJ
cord-018265-twp33bb6	563	194	toxic	toxic	JJ
cord-018265-twp33bb6	563	195	derivatives	derivative	NNS
cord-018265-twp33bb6	563	196	of	of	IN
cord-018265-twp33bb6	563	197	LT	LT	NNP
cord-018265-twp33bb6	563	198	and	and	CC
cord-018265-twp33bb6	563	199	CT	CT	NNP
cord-018265-twp33bb6	563	200	as	as	IN
cord-018265-twp33bb6	563	201	mucosal	mucosal	JJ
cord-018265-twp33bb6	563	202	adjuvants	adjuvant	NNS
cord-018265-twp33bb6	563	203	Detoxification	detoxification	NN
cord-018265-twp33bb6	563	204	of	of	IN
cord-018265-twp33bb6	563	205	cholera	cholera	NN
cord-018265-twp33bb6	563	206	toxin	toxin	NN
cord-018265-twp33bb6	563	207	without	without	IN
cord-018265-twp33bb6	563	208	removal	removal	NN
cord-018265-twp33bb6	563	209	of	of	IN
cord-018265-twp33bb6	563	210	its	-PRON-	PRP$
cord-018265-twp33bb6	563	211	immunoadjuvanticity	immunoadjuvanticity	NN
cord-018265-twp33bb6	563	212	by	by	IN
cord-018265-twp33bb6	563	213	the	the	DT
cord-018265-twp33bb6	563	214	addition	addition	NN
cord-018265-twp33bb6	563	215	of	of	IN
cord-018265-twp33bb6	563	216	(	(	-LRB-
cord-018265-twp33bb6	563	217	STa	sta	NN
cord-018265-twp33bb6	563	218	-	-	HYPH
cord-018265-twp33bb6	563	219	related	relate	VBN
cord-018265-twp33bb6	563	220	)	)	-RRB-
cord-018265-twp33bb6	563	221	peptides	peptide	NNS
cord-018265-twp33bb6	563	222	to	to	IN
cord-018265-twp33bb6	563	223	the	the	DT
cord-018265-twp33bb6	563	224	catalytic	catalytic	JJ
cord-018265-twp33bb6	563	225	subunit	subunit	NN
cord-018265-twp33bb6	563	226	.	.	.
cord-018265-twp33bb6	564	1	A	a	DT
cord-018265-twp33bb6	564	2	potential	potential	JJ
cord-018265-twp33bb6	564	3	new	new	JJ
cord-018265-twp33bb6	564	4	strategy	strategy	NN
cord-018265-twp33bb6	564	5	to	to	TO
cord-018265-twp33bb6	564	6	generate	generate	VB
cord-018265-twp33bb6	564	7	immunostimulants	immunostimulant	NNS
cord-018265-twp33bb6	564	8	for	for	IN
cord-018265-twp33bb6	564	9	vaccination	vaccination	NN
cord-018265-twp33bb6	564	10	Mutant	Mutant	NNP
cord-018265-twp33bb6	564	11	Escherichia	Escherichia	NNP
cord-018265-twp33bb6	564	12	coli	coli	VBZ
cord-018265-twp33bb6	564	13	heat	heat	NN
cord-018265-twp33bb6	564	14	-	-	HYPH
cord-018265-twp33bb6	564	15	labile	labile	JJ
cord-018265-twp33bb6	564	16	enterotoxin	enterotoxin	JJ
cord-018265-twp33bb6	564	17	[	[	-LRB-
cord-018265-twp33bb6	564	18	LT(R192	lt(r192	JJ
cord-018265-twp33bb6	564	19	G	g	NN
cord-018265-twp33bb6	564	20	)	)	-RRB-
cord-018265-twp33bb6	564	21	]	]	-RRB-
cord-018265-twp33bb6	564	22	enhances	enhance	VBZ
cord-018265-twp33bb6	564	23	protective	protective	JJ
cord-018265-twp33bb6	564	24	humoral	humoral	JJ
cord-018265-twp33bb6	564	25	and	and	CC
cord-018265-twp33bb6	564	26	cellular	cellular	JJ
cord-018265-twp33bb6	564	27	immune	immune	JJ
cord-018265-twp33bb6	564	28	responses	response	NNS
cord-018265-twp33bb6	564	29	to	to	IN
cord-018265-twp33bb6	564	30	orally	orally	RB
cord-018265-twp33bb6	564	31	administered	administer	VBN
cord-018265-twp33bb6	564	32	inactivated	inactivate	VBN
cord-018265-twp33bb6	564	33	influenza	influenza	NN
cord-018265-twp33bb6	564	34	vaccine	vaccine	NN
cord-018265-twp33bb6	564	35	Cutting	Cutting	NNP
cord-018265-twp33bb6	564	36	edge	edge	NN
cord-018265-twp33bb6	564	37	:	:	:
cord-018265-twp33bb6	564	38	the	the	DT
cord-018265-twp33bb6	564	39	mucosal	mucosal	JJ
cord-018265-twp33bb6	564	40	adjuvant	adjuvant	JJ
cord-018265-twp33bb6	564	41	cholera	cholera	NN
cord-018265-twp33bb6	564	42	toxin	toxin	NN
cord-018265-twp33bb6	564	43	redirects	redirect	VBZ
cord-018265-twp33bb6	564	44	vaccine	vaccine	NN
cord-018265-twp33bb6	564	45	proteins	protein	NNS
cord-018265-twp33bb6	564	46	into	into	IN
cord-018265-twp33bb6	564	47	olfactory	olfactory	JJ
cord-018265-twp33bb6	564	48	tissues	tissue	NNS
cord-018265-twp33bb6	564	49	Induction	induction	NN
cord-018265-twp33bb6	564	50	and	and	CC
cord-018265-twp33bb6	564	51	recall	recall	NN
cord-018265-twp33bb6	564	52	of	of	IN
cord-018265-twp33bb6	564	53	immune	immune	JJ
cord-018265-twp33bb6	564	54	memory	memory	NN
cord-018265-twp33bb6	564	55	by	by	IN
cord-018265-twp33bb6	564	56	mucosal	mucosal	JJ
cord-018265-twp33bb6	564	57	immunization	immunization	NN
cord-018265-twp33bb6	564	58	with	with	IN
cord-018265-twp33bb6	564	59	a	a	DT
cord-018265-twp33bb6	564	60	non	non	JJ
cord-018265-twp33bb6	564	61	-	-	JJ
cord-018265-twp33bb6	564	62	toxic	toxic	JJ
cord-018265-twp33bb6	564	63	recombinant	recombinant	JJ
cord-018265-twp33bb6	564	64	enterotoxin	enterotoxin	NN
cord-018265-twp33bb6	564	65	-	-	HYPH
cord-018265-twp33bb6	564	66	based	base	VBN
cord-018265-twp33bb6	564	67	chimeric	chimeric	JJ
cord-018265-twp33bb6	564	68	protein	protein	NN
cord-018265-twp33bb6	564	69	Expression	expression	NN
cord-018265-twp33bb6	564	70	and	and	CC
cord-018265-twp33bb6	564	71	characterization	characterization	NN
cord-018265-twp33bb6	564	72	of	of	IN
cord-018265-twp33bb6	564	73	cholera	cholera	NN
cord-018265-twp33bb6	564	74	toxin	toxin	NN
cord-018265-twp33bb6	564	75	B	b	NN
cord-018265-twp33bb6	564	76	-	-	HYPH
cord-018265-twp33bb6	564	77	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	564	78	surface	surface	NN
cord-018265-twp33bb6	564	79	adhesin	adhesin	NNP
cord-018265-twp33bb6	565	1	A	a	DT
cord-018265-twp33bb6	565	2	fusion	fusion	NN
cord-018265-twp33bb6	565	3	protein	protein	NN
cord-018265-twp33bb6	565	4	in	in	IN
cord-018265-twp33bb6	565	5	Escherichia	Escherichia	NNP
cord-018265-twp33bb6	565	6	coli	coli	NNS
cord-018265-twp33bb6	565	7	:	:	:
cord-018265-twp33bb6	565	8	ability	ability	NN
cord-018265-twp33bb6	565	9	of	of	IN
cord-018265-twp33bb6	565	10	CTB	CTB	NNP
cord-018265-twp33bb6	565	11	-	-	HYPH
cord-018265-twp33bb6	565	12	PsaA	PsaA	NNP
cord-018265-twp33bb6	565	13	to	to	TO
cord-018265-twp33bb6	565	14	induce	induce	VB
cord-018265-twp33bb6	565	15	humoral	humoral	JJ
cord-018265-twp33bb6	565	16	immune	immune	JJ
cord-018265-twp33bb6	565	17	response	response	NN
cord-018265-twp33bb6	565	18	in	in	IN
cord-018265-twp33bb6	565	19	mice	mouse	NNS
cord-018265-twp33bb6	566	1	Intranasal	intranasal	NN
cord-018265-twp33bb6	566	2	immunization	immunization	NN
cord-018265-twp33bb6	566	3	enhances	enhance	VBZ
cord-018265-twp33bb6	566	4	clearance	clearance	NN
cord-018265-twp33bb6	566	5	of	of	IN
cord-018265-twp33bb6	566	6	nontypeable	nontypeable	JJ
cord-018265-twp33bb6	566	7	Haemophilus	Haemophilus	NNP
cord-018265-twp33bb6	566	8	influenzae	influenzae	NN
cord-018265-twp33bb6	566	9	and	and	CC
cord-018265-twp33bb6	566	10	reduces	reduce	VBZ
cord-018265-twp33bb6	566	11	stimulation	stimulation	NN
cord-018265-twp33bb6	566	12	of	of	IN
cord-018265-twp33bb6	566	13	tumor	tumor	NN
cord-018265-twp33bb6	566	14	necrosis	necrosis	NN
cord-018265-twp33bb6	566	15	factor	factor	NN
cord-018265-twp33bb6	566	16	alpha	alpha	NN
cord-018265-twp33bb6	566	17	production	production	NN
cord-018265-twp33bb6	566	18	in	in	IN
cord-018265-twp33bb6	566	19	the	the	DT
cord-018265-twp33bb6	566	20	murine	murine	JJ
cord-018265-twp33bb6	566	21	model	model	NN
cord-018265-twp33bb6	566	22	of	of	IN
cord-018265-twp33bb6	566	23	otitis	otitis	NN
cord-018265-twp33bb6	566	24	media	medium	NNS
cord-018265-twp33bb6	566	25	Fibronectin	Fibronectin	NNP
cord-018265-twp33bb6	566	26	-	-	HYPH
cord-018265-twp33bb6	566	27	binding	bind	VBG
cord-018265-twp33bb6	566	28	protein	protein	NN
cord-018265-twp33bb6	566	29	I	-PRON-	PRP
cord-018265-twp33bb6	566	30	of	of	IN
cord-018265-twp33bb6	566	31	Streptococcus	Streptococcus	NNP
cord-018265-twp33bb6	566	32	pyogenes	pyogene	NNS
cord-018265-twp33bb6	566	33	is	be	VBZ
cord-018265-twp33bb6	566	34	a	a	DT
cord-018265-twp33bb6	566	35	promising	promising	JJ
cord-018265-twp33bb6	566	36	adjuvant	adjuvant	NN
cord-018265-twp33bb6	566	37	for	for	IN
cord-018265-twp33bb6	566	38	antigens	antigen	NNS
cord-018265-twp33bb6	566	39	delivered	deliver	VBN
cord-018265-twp33bb6	566	40	by	by	IN
cord-018265-twp33bb6	566	41	mucosal	mucosal	JJ
cord-018265-twp33bb6	566	42	route	route	NN
cord-018265-twp33bb6	566	43	Innate	innate	JJ
cord-018265-twp33bb6	566	44	immune	immune	JJ
cord-018265-twp33bb6	566	45	recognition	recognition	NN
cord-018265-twp33bb6	567	1	The	the	DT
cord-018265-twp33bb6	567	2	evolution	evolution	NN
cord-018265-twp33bb6	567	3	of	of	IN
cord-018265-twp33bb6	567	4	vertebrate	vertebrate	NN
cord-018265-twp33bb6	568	1	Toll	toll	NN
cord-018265-twp33bb6	568	2	-	-	HYPH
cord-018265-twp33bb6	568	3	like	like	JJ
cord-018265-twp33bb6	568	4	receptors	receptor	NNS
cord-018265-twp33bb6	569	1	Toll	toll	NN
cord-018265-twp33bb6	569	2	-	-	HYPH
cord-018265-twp33bb6	569	3	like	like	JJ
cord-018265-twp33bb6	569	4	receptor	receptor	NN
cord-018265-twp33bb6	569	5	9	9	CD
cord-018265-twp33bb6	569	6	mediates	mediate	VBZ
cord-018265-twp33bb6	569	7	CpG	CpG	NNP
cord-018265-twp33bb6	569	8	-	-	HYPH
cord-018265-twp33bb6	569	9	DNA	DNA	NNP
cord-018265-twp33bb6	569	10	signaling	signal	VBG
cord-018265-twp33bb6	569	11	The	the	DT
cord-018265-twp33bb6	569	12	immunobiology	immunobiology	NN
cord-018265-twp33bb6	569	13	of	of	IN
cord-018265-twp33bb6	569	14	the	the	DT
cord-018265-twp33bb6	569	15	TLR9	TLR9	NNP
cord-018265-twp33bb6	569	16	subfamily	subfamily	NN
cord-018265-twp33bb6	569	17	Mucosal	Mucosal	NNP
cord-018265-twp33bb6	569	18	immunity	immunity	NN
cord-018265-twp33bb6	569	19	induced	induce	VBN
cord-018265-twp33bb6	569	20	by	by	IN
cord-018265-twp33bb6	569	21	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	569	22	glycoconjugate	glycoconjugate	NNP
cord-018265-twp33bb6	569	23	Safety	safety	NN
cord-018265-twp33bb6	569	24	and	and	CC
cord-018265-twp33bb6	569	25	immunogenicity	immunogenicity	NN
cord-018265-twp33bb6	569	26	of	of	IN
cord-018265-twp33bb6	569	27	CPG	CPG	NNP
cord-018265-twp33bb6	569	28	7909	7909	CD
cord-018265-twp33bb6	569	29	injection	injection	NN
cord-018265-twp33bb6	569	30	as	as	IN
cord-018265-twp33bb6	569	31	an	an	DT
cord-018265-twp33bb6	569	32	adjuvant	adjuvant	NN
cord-018265-twp33bb6	569	33	to	to	IN
cord-018265-twp33bb6	569	34	Fluarix	Fluarix	NNP
cord-018265-twp33bb6	569	35	influenza	influenza	NN
cord-018265-twp33bb6	569	36	vaccine	vaccine	NN
cord-018265-twp33bb6	570	1	The	the	DT
cord-018265-twp33bb6	570	2	adjuvant	adjuvant	JJ
cord-018265-twp33bb6	570	3	effect	effect	NN
cord-018265-twp33bb6	570	4	of	of	IN
cord-018265-twp33bb6	570	5	synthetic	synthetic	JJ
cord-018265-twp33bb6	570	6	oligodeoxynucleotide	oligodeoxynucleotide	JJ
cord-018265-twp33bb6	570	7	containing	contain	VBG
cord-018265-twp33bb6	570	8	CpG	CpG	NNP
cord-018265-twp33bb6	570	9	motif	motif	NN
cord-018265-twp33bb6	570	10	converts	convert	VBZ
cord-018265-twp33bb6	570	11	the	the	DT
cord-018265-twp33bb6	570	12	anti	anti	JJ
cord-018265-twp33bb6	570	13	-	-	JJ
cord-018265-twp33bb6	570	14	Haemophilus	haemophilus	JJ
cord-018265-twp33bb6	570	15	influenzae	influenzae	NN
cord-018265-twp33bb6	570	16	type	type	NN
cord-018265-twp33bb6	570	17	b	b	NN
cord-018265-twp33bb6	570	18	glycoconjugates	glycoconjugate	NNS
cord-018265-twp33bb6	570	19	into	into	IN
cord-018265-twp33bb6	570	20	efficient	efficient	JJ
cord-018265-twp33bb6	570	21	anti	anti	JJ
cord-018265-twp33bb6	570	22	-	-	JJ
cord-018265-twp33bb6	570	23	polysaccharide	polysaccharide	JJ
cord-018265-twp33bb6	570	24	and	and	CC
cord-018265-twp33bb6	570	25	anti	anti	JJ
cord-018265-twp33bb6	570	26	-	-	JJ
cord-018265-twp33bb6	570	27	carrier	carrier	JJ
cord-018265-twp33bb6	570	28	polyvalent	polyvalent	JJ
cord-018265-twp33bb6	570	29	vaccines	vaccine	NNS
cord-018265-twp33bb6	571	1	Mycoplasmal	Mycoplasmal	NNP
cord-018265-twp33bb6	571	2	lipopeptide	lipopeptide	NN
cord-018265-twp33bb6	571	3	MALP-2	MALP-2	NNP
cord-018265-twp33bb6	571	4	induces	induce	VBZ
cord-018265-twp33bb6	571	5	the	the	DT
cord-018265-twp33bb6	571	6	chemoattractant	chemoattractant	NN
cord-018265-twp33bb6	571	7	proteins	protein	NNS
cord-018265-twp33bb6	571	8	macrophage	macrophage	VBP
cord-018265-twp33bb6	571	9	inflammatory	inflammatory	JJ
cord-018265-twp33bb6	571	10	protein	protein	NN
cord-018265-twp33bb6	571	11	1alpha	1alpha	CD
cord-018265-twp33bb6	571	12	(	(	-LRB-
cord-018265-twp33bb6	571	13	MIP-1alpha	MIP-1alpha	NNP
cord-018265-twp33bb6	571	14	)	)	-RRB-
cord-018265-twp33bb6	571	15	,	,	,
cord-018265-twp33bb6	571	16	monocyte	monocyte	NNP
cord-018265-twp33bb6	571	17	chemoattractant	chemoattractant	NNP
cord-018265-twp33bb6	571	18	protein	protein	NNP
cord-018265-twp33bb6	571	19	1	1	CD
cord-018265-twp33bb6	571	20	,	,	,
cord-018265-twp33bb6	571	21	and	and	CC
cord-018265-twp33bb6	571	22	MIP-2	MIP-2	NNP
cord-018265-twp33bb6	571	23	and	and	CC
cord-018265-twp33bb6	571	24	promotes	promote	VBZ
cord-018265-twp33bb6	571	25	leukocyte	leukocyte	NN
cord-018265-twp33bb6	571	26	infiltration	infiltration	NN
cord-018265-twp33bb6	571	27	in	in	IN
cord-018265-twp33bb6	571	28	mice	mouse	NNS
cord-018265-twp33bb6	571	29	Isolation	isolation	NN
cord-018265-twp33bb6	571	30	,	,	,
cord-018265-twp33bb6	571	31	structure	structure	NN
cord-018265-twp33bb6	571	32	elucidation	elucidation	NN
cord-018265-twp33bb6	571	33	,	,	,
cord-018265-twp33bb6	571	34	and	and	CC
cord-018265-twp33bb6	571	35	synthesis	synthesis	NN
cord-018265-twp33bb6	571	36	of	of	IN
cord-018265-twp33bb6	571	37	a	a	DT
cord-018265-twp33bb6	571	38	macrophage	macrophage	NN
cord-018265-twp33bb6	571	39	stimulatory	stimulatory	JJ
cord-018265-twp33bb6	571	40	lipopeptide	lipopeptide	NN
cord-018265-twp33bb6	571	41	from	from	IN
cord-018265-twp33bb6	571	42	Mycoplasma	Mycoplasma	NNP
cord-018265-twp33bb6	571	43	fermentans	fermentans	NNP
cord-018265-twp33bb6	571	44	acting	act	VBG
cord-018265-twp33bb6	571	45	at	at	IN
cord-018265-twp33bb6	571	46	picomolar	picomolar	NNP
cord-018265-twp33bb6	571	47	concentration	concentration	NN
cord-018265-twp33bb6	571	48	Toll	Toll	NNP
cord-018265-twp33bb6	571	49	-	-	HYPH
cord-018265-twp33bb6	571	50	like	like	JJ
cord-018265-twp33bb6	571	51	receptor	receptor	NN
cord-018265-twp33bb6	571	52	2-and	2-and	CD
cord-018265-twp33bb6	572	1	6-mediated	6-mediated	CD
cord-018265-twp33bb6	572	2	stimulation	stimulation	NN
cord-018265-twp33bb6	572	3	by	by	IN
cord-018265-twp33bb6	572	4	macrophage	macrophage	NN
cord-018265-twp33bb6	572	5	-	-	HYPH
cord-018265-twp33bb6	572	6	activating	activate	VBG
cord-018265-twp33bb6	572	7	lipopeptide	lipopeptide	NNP
cord-018265-twp33bb6	572	8	2	2	CD
cord-018265-twp33bb6	572	9	induces	induce	VBZ
cord-018265-twp33bb6	572	10	lipopolysaccharide	lipopolysaccharide	NN
cord-018265-twp33bb6	572	11	(	(	-LRB-
cord-018265-twp33bb6	572	12	LPS	LPS	NNP
cord-018265-twp33bb6	572	13	)	)	-RRB-
cord-018265-twp33bb6	573	1	cross	cross	VB
cord-018265-twp33bb6	573	2	tolerance	tolerance	NN
cord-018265-twp33bb6	573	3	in	in	IN
cord-018265-twp33bb6	573	4	mice	mouse	NNS
cord-018265-twp33bb6	573	5	,	,	,
cord-018265-twp33bb6	573	6	which	which	WDT
cord-018265-twp33bb6	573	7	results	result	VBZ
cord-018265-twp33bb6	573	8	in	in	IN
cord-018265-twp33bb6	573	9	protection	protection	NN
cord-018265-twp33bb6	573	10	from	from	IN
cord-018265-twp33bb6	573	11	tumor	tumor	NN
cord-018265-twp33bb6	573	12	necrosis	necrosis	NN
cord-018265-twp33bb6	573	13	factor	factor	NN
cord-018265-twp33bb6	573	14	alpha	alpha	NN
cord-018265-twp33bb6	573	15	but	but	CC
cord-018265-twp33bb6	573	16	in	in	IN
cord-018265-twp33bb6	573	17	only	only	JJ
cord-018265-twp33bb6	573	18	partial	partial	JJ
cord-018265-twp33bb6	573	19	protection	protection	NN
cord-018265-twp33bb6	573	20	from	from	IN
cord-018265-twp33bb6	573	21	lethal	lethal	JJ
cord-018265-twp33bb6	573	22	LPS	LPS	NNP
cord-018265-twp33bb6	573	23	doses	dose	NNS
cord-018265-twp33bb6	573	24	Stimulation	stimulation	NN
cord-018265-twp33bb6	573	25	of	of	IN
cord-018265-twp33bb6	573	26	human	human	JJ
cord-018265-twp33bb6	573	27	Toll	toll	NN
cord-018265-twp33bb6	573	28	-	-	HYPH
cord-018265-twp33bb6	573	29	like	like	JJ
cord-018265-twp33bb6	573	30	receptor	receptor	NN
cord-018265-twp33bb6	573	31	(	(	-LRB-
cord-018265-twp33bb6	573	32	TLR	TLR	NNP
cord-018265-twp33bb6	573	33	)	)	-RRB-
cord-018265-twp33bb6	573	34	2	2	CD
cord-018265-twp33bb6	573	35	and	and	CC
cord-018265-twp33bb6	573	36	TLR6	TLR6	NNP
cord-018265-twp33bb6	573	37	with	with	IN
cord-018265-twp33bb6	573	38	membrane	membrane	NN
cord-018265-twp33bb6	573	39	lipoproteins	lipoprotein	NNS
cord-018265-twp33bb6	573	40	of	of	IN
cord-018265-twp33bb6	573	41	Mycoplasma	Mycoplasma	NNP
cord-018265-twp33bb6	573	42	fermentans	fermentans	NNP
cord-018265-twp33bb6	573	43	induces	induce	VBZ
cord-018265-twp33bb6	573	44	apoptotic	apoptotic	JJ
cord-018265-twp33bb6	573	45	cell	cell	NN
cord-018265-twp33bb6	573	46	death	death	NN
cord-018265-twp33bb6	573	47	after	after	IN
cord-018265-twp33bb6	573	48	NF	nf	NN
cord-018265-twp33bb6	573	49	-	-	HYPH
cord-018265-twp33bb6	573	50	kappa	kappa	NN
cord-018265-twp33bb6	573	51	B	B	NNP
cord-018265-twp33bb6	573	52	activation	activation	NN
cord-018265-twp33bb6	574	1	The	the	DT
cord-018265-twp33bb6	574	2	Toll	Toll	NNP
cord-018265-twp33bb6	574	3	-	-	HYPH
cord-018265-twp33bb6	574	4	like	like	JJ
cord-018265-twp33bb6	574	5	receptor	receptor	NN
cord-018265-twp33bb6	574	6	ligand	ligand	NN
cord-018265-twp33bb6	574	7	MALP-2	MALP-2	NNP
cord-018265-twp33bb6	574	8	stimulates	stimulate	VBZ
cord-018265-twp33bb6	574	9	dendritic	dendritic	JJ
cord-018265-twp33bb6	574	10	cell	cell	NN
cord-018265-twp33bb6	574	11	maturation	maturation	NN
cord-018265-twp33bb6	574	12	and	and	CC
cord-018265-twp33bb6	574	13	modulates	modulate	VBZ
cord-018265-twp33bb6	574	14	proteasome	proteasome	VBN
cord-018265-twp33bb6	574	15	composition	composition	NN
cord-018265-twp33bb6	574	16	and	and	CC
cord-018265-twp33bb6	574	17	activity	activity	NN
cord-018265-twp33bb6	575	1	The	the	DT
cord-018265-twp33bb6	575	2	Mycoplasma	Mycoplasma	NNP
cord-018265-twp33bb6	575	3	-	-	HYPH
cord-018265-twp33bb6	575	4	derived	derive	VBN
cord-018265-twp33bb6	575	5	lipopeptide	lipopeptide	NN
cord-018265-twp33bb6	575	6	MALP-2	MALP-2	NNP
cord-018265-twp33bb6	575	7	is	be	VBZ
cord-018265-twp33bb6	575	8	a	a	DT
cord-018265-twp33bb6	575	9	potent	potent	JJ
cord-018265-twp33bb6	575	10	mucosal	mucosal	NN
cord-018265-twp33bb6	575	11	adjuvant	adjuvant	JJ
cord-018265-twp33bb6	575	12	DNA	dna	NN
cord-018265-twp33bb6	575	13	vaccines	vaccine	NNS
cord-018265-twp33bb6	575	14	:	:	:
cord-018265-twp33bb6	575	15	immunology	immunology	NN
cord-018265-twp33bb6	575	16	,	,	,
cord-018265-twp33bb6	575	17	application	application	NN
cord-018265-twp33bb6	575	18	,	,	,
cord-018265-twp33bb6	575	19	and	and	CC
cord-018265-twp33bb6	575	20	optimization	optimization	NN
cord-018265-twp33bb6	576	1	*	*	NFP
cord-018265-twp33bb6	576	2	Bacterial	bacterial	JJ
cord-018265-twp33bb6	576	3	ghosts	ghost	NNS
cord-018265-twp33bb6	576	4	are	be	VBP
cord-018265-twp33bb6	576	5	an	an	DT
cord-018265-twp33bb6	576	6	efficient	efficient	JJ
cord-018265-twp33bb6	576	7	delivery	delivery	NN
cord-018265-twp33bb6	576	8	system	system	NN
cord-018265-twp33bb6	576	9	for	for	IN
cord-018265-twp33bb6	576	10	DNA	dna	NN
cord-018265-twp33bb6	576	11	vaccines	vaccine	NNS
cord-018265-twp33bb6	577	1	Polynucleotide	polynucleotide	JJ
cord-018265-twp33bb6	577	2	viral	viral	JJ
cord-018265-twp33bb6	577	3	vaccines	vaccine	NNS
cord-018265-twp33bb6	577	4	:	:	:
cord-018265-twp33bb6	578	1	codon	codon	NNP
cord-018265-twp33bb6	578	2	optimisation	optimisation	NN
cord-018265-twp33bb6	578	3	and	and	CC
cord-018265-twp33bb6	578	4	ubiquitin	ubiquitin	NN
cord-018265-twp33bb6	578	5	conjugation	conjugation	NN
cord-018265-twp33bb6	578	6	enhances	enhance	VBZ
cord-018265-twp33bb6	578	7	prophylactic	prophylactic	JJ
cord-018265-twp33bb6	578	8	and	and	CC
cord-018265-twp33bb6	578	9	therapeutic	therapeutic	JJ
cord-018265-twp33bb6	578	10	efficacy	efficacy	NN
cord-018265-twp33bb6	579	1	Preclinical	preclinical	JJ
cord-018265-twp33bb6	579	2	efficacy	efficacy	NN
cord-018265-twp33bb6	579	3	of	of	IN
cord-018265-twp33bb6	579	4	a	a	DT
cord-018265-twp33bb6	579	5	prototype	prototype	NN
cord-018265-twp33bb6	579	6	DNA	dna	NN
cord-018265-twp33bb6	579	7	vaccine	vaccine	NN
cord-018265-twp33bb6	579	8	:	:	:
cord-018265-twp33bb6	579	9	enhanced	enhance	VBN
cord-018265-twp33bb6	579	10	protection	protection	NN
cord-018265-twp33bb6	579	11	against	against	IN
cord-018265-twp33bb6	579	12	antigenic	antigenic	JJ
cord-018265-twp33bb6	579	13	drift	drift	NN
cord-018265-twp33bb6	579	14	in	in	IN
cord-018265-twp33bb6	579	15	influenza	influenza	NN
cord-018265-twp33bb6	579	16	virus	virus	NN
cord-018265-twp33bb6	579	17	Successful	successful	JJ
cord-018265-twp33bb6	579	18	nucleic	nucleic	JJ
cord-018265-twp33bb6	579	19	acid	acid	NN
cord-018265-twp33bb6	579	20	based	base	VBN
cord-018265-twp33bb6	579	21	immunization	immunization	NN
cord-018265-twp33bb6	579	22	of	of	IN
cord-018265-twp33bb6	579	23	newborn	newborn	JJ
cord-018265-twp33bb6	579	24	chimpanzees	chimpanzee	NNS
cord-018265-twp33bb6	579	25	against	against	IN
cord-018265-twp33bb6	579	26	hepatitis	hepatitis	NNP
cord-018265-twp33bb6	579	27	B	B	NNP
cord-018265-twp33bb6	579	28	virus	virus	NN
cord-018265-twp33bb6	580	1	The	the	DT
cord-018265-twp33bb6	580	2	potential	potential	JJ
cord-018265-twp33bb6	580	3	use	use	NN
cord-018265-twp33bb6	580	4	of	of	IN
cord-018265-twp33bb6	580	5	DNA	dna	NN
cord-018265-twp33bb6	580	6	vaccines	vaccine	NNS
cord-018265-twp33bb6	580	7	for	for	IN
cord-018265-twp33bb6	580	8	neonatal	neonatal	JJ
cord-018265-twp33bb6	580	9	immunization	immunization	NN
cord-018265-twp33bb6	580	10	Cross	Cross	NNP
cord-018265-twp33bb6	580	11	-	-	JJ
cord-018265-twp33bb6	580	12	reactive	reactive	JJ
cord-018265-twp33bb6	580	13	protection	protection	NN
cord-018265-twp33bb6	580	14	against	against	IN
cord-018265-twp33bb6	580	15	influenza	influenza	NN
cord-018265-twp33bb6	580	16	A	a	DT
cord-018265-twp33bb6	580	17	virus	virus	NN
cord-018265-twp33bb6	580	18	by	by	IN
cord-018265-twp33bb6	580	19	a	a	DT
cord-018265-twp33bb6	580	20	topically	topically	RB
cord-018265-twp33bb6	580	21	applied	apply	VBN
cord-018265-twp33bb6	580	22	DNA	dna	NN
cord-018265-twp33bb6	580	23	vaccine	vaccine	NN
cord-018265-twp33bb6	580	24	encoding	encode	VBG
cord-018265-twp33bb6	580	25	M	M	NNP
cord-018265-twp33bb6	580	26	gene	gene	NN
cord-018265-twp33bb6	580	27	with	with	IN
cord-018265-twp33bb6	580	28	adjuvant	adjuvant	JJ
cord-018265-twp33bb6	580	29	Protective	protective	JJ
cord-018265-twp33bb6	580	30	efficacy	efficacy	NN
cord-018265-twp33bb6	580	31	of	of	IN
cord-018265-twp33bb6	580	32	PspA	PspA	NNP
cord-018265-twp33bb6	580	33	(	(	-LRB-
cord-018265-twp33bb6	580	34	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	580	35	surface	surface	NN
cord-018265-twp33bb6	580	36	protein	protein	NN
cord-018265-twp33bb6	580	37	A)-based	A)-based	NNP
cord-018265-twp33bb6	580	38	DNA	DNA	NNP
cord-018265-twp33bb6	580	39	vaccines	vaccine	NNS
cord-018265-twp33bb6	580	40	:	:	:
cord-018265-twp33bb6	581	1	contribution	contribution	NN
cord-018265-twp33bb6	581	2	of	of	IN
cord-018265-twp33bb6	581	3	both	both	CC
cord-018265-twp33bb6	581	4	humoral	humoral	JJ
cord-018265-twp33bb6	581	5	and	and	CC
cord-018265-twp33bb6	581	6	cellular	cellular	JJ
cord-018265-twp33bb6	581	7	immune	immune	JJ
cord-018265-twp33bb6	581	8	responses	response	NNS
cord-018265-twp33bb6	581	9	Protective	protective	JJ
cord-018265-twp33bb6	581	10	long	long	JJ
cord-018265-twp33bb6	581	11	-	-	HYPH
cord-018265-twp33bb6	581	12	term	term	NN
cord-018265-twp33bb6	581	13	antibody	antibody	NN
cord-018265-twp33bb6	581	14	memory	memory	NN
cord-018265-twp33bb6	581	15	by	by	IN
cord-018265-twp33bb6	581	16	antigendriven	antigendriven	NNP
cord-018265-twp33bb6	581	17	and	and	CC
cord-018265-twp33bb6	581	18	T	T	NNP
cord-018265-twp33bb6	582	1	help	help	VB
cord-018265-twp33bb6	582	2	-	-	HYPH
cord-018265-twp33bb6	582	3	dependent	dependent	JJ
cord-018265-twp33bb6	582	4	differentiation	differentiation	NN
cord-018265-twp33bb6	582	5	of	of	IN
cord-018265-twp33bb6	582	6	long	long	RB
cord-018265-twp33bb6	582	7	-	-	HYPH
cord-018265-twp33bb6	582	8	lived	live	VBN
cord-018265-twp33bb6	582	9	memory	memory	NN
cord-018265-twp33bb6	582	10	B	b	NN
cord-018265-twp33bb6	582	11	cells	cell	NNS
cord-018265-twp33bb6	582	12	to	to	IN
cord-018265-twp33bb6	582	13	short	short	RB
cord-018265-twp33bb6	582	14	-	-	HYPH
cord-018265-twp33bb6	582	15	lived	live	VBN
cord-018265-twp33bb6	582	16	plasma	plasma	NN
cord-018265-twp33bb6	582	17	cells	cell	NNS
cord-018265-twp33bb6	582	18	independent	independent	JJ
cord-018265-twp33bb6	582	19	of	of	IN
cord-018265-twp33bb6	582	20	secondary	secondary	JJ
cord-018265-twp33bb6	582	21	lymphoid	lymphoid	JJ
cord-018265-twp33bb6	582	22	organs	organ	NNS
cord-018265-twp33bb6	583	1	On	on	IN
cord-018265-twp33bb6	583	2	differences	difference	NNS
cord-018265-twp33bb6	583	3	between	between	IN
cord-018265-twp33bb6	583	4	immunity	immunity	NN
cord-018265-twp33bb6	583	5	and	and	CC
cord-018265-twp33bb6	583	6	immunological	immunological	JJ
cord-018265-twp33bb6	583	7	memory	memory	NN
cord-018265-twp33bb6	583	8	Kinetics	kinetic	NNS
cord-018265-twp33bb6	583	9	of	of	IN
cord-018265-twp33bb6	583	10	protective	protective	JJ
cord-018265-twp33bb6	583	11	antibodies	antibody	NNS
cord-018265-twp33bb6	583	12	are	be	VBP
cord-018265-twp33bb6	583	13	determined	determine	VBN
cord-018265-twp33bb6	583	14	by	by	IN
cord-018265-twp33bb6	583	15	the	the	DT
cord-018265-twp33bb6	583	16	viral	viral	JJ
cord-018265-twp33bb6	583	17	surface	surface	NN
cord-018265-twp33bb6	583	18	antigen	antigen	NN
cord-018265-twp33bb6	583	19	Haemophilus	haemophilus	JJ
cord-018265-twp33bb6	583	20	influenzae	influenzae	NN
cord-018265-twp33bb6	583	21	type	type	NN
cord-018265-twp33bb6	583	22	b	b	NN
cord-018265-twp33bb6	583	23	conjugate	conjugate	VB
cord-018265-twp33bb6	583	24	vaccine	vaccine	NN
cord-018265-twp33bb6	583	25	diluted	dilute	VBN
cord-018265-twp33bb6	583	26	tenfold	tenfold	RB
cord-018265-twp33bb6	583	27	in	in	IN
cord-018265-twp33bb6	583	28	diphtheriatetanus	diphtheriatetanus	JJ
cord-018265-twp33bb6	583	29	-	-	HYPH
cord-018265-twp33bb6	583	30	whole	whole	JJ
cord-018265-twp33bb6	583	31	cell	cell	NN
cord-018265-twp33bb6	583	32	pertussis	pertussis	NN
cord-018265-twp33bb6	583	33	vaccine	vaccine	NN
cord-018265-twp33bb6	583	34	:	:	:
cord-018265-twp33bb6	583	35	a	a	DT
cord-018265-twp33bb6	583	36	randomized	randomized	JJ
cord-018265-twp33bb6	583	37	trial	trial	NN
cord-018265-twp33bb6	584	1	A	a	DT
cord-018265-twp33bb6	584	2	randomized	randomized	JJ
cord-018265-twp33bb6	584	3	trial	trial	NN
cord-018265-twp33bb6	584	4	of	of	IN
cord-018265-twp33bb6	584	5	alternative	alternative	JJ
cord-018265-twp33bb6	584	6	two	two	CD
cord-018265-twp33bb6	584	7	-	-	HYPH
cord-018265-twp33bb6	584	8	and	and	CC
cord-018265-twp33bb6	584	9	three	three	CD
cord-018265-twp33bb6	584	10	-	-	HYPH
cord-018265-twp33bb6	584	11	dose	dose	NN
cord-018265-twp33bb6	584	12	hepatitis	hepatitis	NN
cord-018265-twp33bb6	584	13	B	B	NNP
cord-018265-twp33bb6	584	14	vaccination	vaccination	NN
cord-018265-twp33bb6	584	15	regimens	regimen	NNS
cord-018265-twp33bb6	584	16	in	in	IN
cord-018265-twp33bb6	584	17	adolescents	adolescent	NNS
cord-018265-twp33bb6	584	18	:	:	:
cord-018265-twp33bb6	584	19	antibody	antibody	NN
cord-018265-twp33bb6	584	20	responses	response	NNS
cord-018265-twp33bb6	584	21	,	,	,
cord-018265-twp33bb6	584	22	safety	safety	NN
cord-018265-twp33bb6	584	23	,	,	,
cord-018265-twp33bb6	584	24	and	and	CC
cord-018265-twp33bb6	584	25	immunologic	immunologic	JJ
cord-018265-twp33bb6	584	26	memory	memory	NN
cord-018265-twp33bb6	585	1	Dose	dose	JJ
cord-018265-twp33bb6	585	2	dependency	dependency	NN
cord-018265-twp33bb6	585	3	of	of	IN
cord-018265-twp33bb6	585	4	antibody	antibody	NN
cord-018265-twp33bb6	585	5	response	response	NN
cord-018265-twp33bb6	585	6	in	in	IN
cord-018265-twp33bb6	585	7	infants	infant	NNS
cord-018265-twp33bb6	585	8	and	and	CC
cord-018265-twp33bb6	585	9	children	child	NNS
cord-018265-twp33bb6	585	10	to	to	IN
cord-018265-twp33bb6	585	11	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	585	12	polysaccharides	polysaccharide	NNS
cord-018265-twp33bb6	585	13	conjugated	conjugate	VBN
cord-018265-twp33bb6	585	14	to	to	IN
cord-018265-twp33bb6	585	15	tetanus	tetanus	NN
cord-018265-twp33bb6	586	1	toxoid	toxoid	NNP
cord-018265-twp33bb6	586	2	Accelerated	accelerate	VBN
cord-018265-twp33bb6	586	3	hepatitis	hepatitis	NN
cord-018265-twp33bb6	586	4	B	B	NNP
cord-018265-twp33bb6	586	5	vaccination	vaccination	NN
cord-018265-twp33bb6	586	6	schedule	schedule	NN
cord-018265-twp33bb6	586	7	in	in	IN
cord-018265-twp33bb6	586	8	childhood	childhood	NN
cord-018265-twp33bb6	586	9	Immunological	immunological	JJ
cord-018265-twp33bb6	586	10	response	response	NN
cord-018265-twp33bb6	586	11	to	to	TO
cord-018265-twp33bb6	586	12	conjugate	conjugate	VB
cord-018265-twp33bb6	586	13	vaccines	vaccine	NNS
cord-018265-twp33bb6	586	14	in	in	IN
cord-018265-twp33bb6	586	15	infants	infant	NNS
cord-018265-twp33bb6	586	16	:	:	:
cord-018265-twp33bb6	586	17	follow	follow	VB
cord-018265-twp33bb6	586	18	up	up	RP
cord-018265-twp33bb6	586	19	study	study	NN
cord-018265-twp33bb6	586	20	Neonatal	neonatal	JJ
cord-018265-twp33bb6	586	21	and	and	CC
cord-018265-twp33bb6	586	22	early	early	JJ
cord-018265-twp33bb6	586	23	life	life	NN
cord-018265-twp33bb6	587	1	vaccinology	vaccinology	NN
cord-018265-twp33bb6	587	2	Unresponsiveness	Unresponsiveness	NNP
cord-018265-twp33bb6	587	3	to	to	IN
cord-018265-twp33bb6	587	4	lymphoid	lymphoid	NN
cord-018265-twp33bb6	587	5	-	-	HYPH
cord-018265-twp33bb6	587	6	mediated	mediate	VBN
cord-018265-twp33bb6	587	7	signals	signal	NNS
cord-018265-twp33bb6	587	8	at	at	IN
cord-018265-twp33bb6	587	9	the	the	DT
cord-018265-twp33bb6	587	10	neonatal	neonatal	JJ
cord-018265-twp33bb6	587	11	follicular	follicular	JJ
cord-018265-twp33bb6	587	12	dendritic	dendritic	JJ
cord-018265-twp33bb6	587	13	cell	cell	NN
cord-018265-twp33bb6	587	14	precursor	precursor	NN
cord-018265-twp33bb6	587	15	level	level	NN
cord-018265-twp33bb6	587	16	contributes	contribute	VBZ
cord-018265-twp33bb6	587	17	to	to	IN
cord-018265-twp33bb6	587	18	delayed	delay	VBN
cord-018265-twp33bb6	587	19	germinal	germinal	JJ
cord-018265-twp33bb6	587	20	center	center	NN
cord-018265-twp33bb6	587	21	induction	induction	NN
cord-018265-twp33bb6	587	22	and	and	CC
cord-018265-twp33bb6	587	23	limitations	limitation	NNS
cord-018265-twp33bb6	587	24	of	of	IN
cord-018265-twp33bb6	587	25	neonatal	neonatal	JJ
cord-018265-twp33bb6	587	26	antibody	antibody	NN
cord-018265-twp33bb6	587	27	responses	response	NNS
cord-018265-twp33bb6	587	28	to	to	IN
cord-018265-twp33bb6	587	29	T	t	NN
cord-018265-twp33bb6	587	30	-	-	HYPH
cord-018265-twp33bb6	587	31	dependent	dependent	JJ
cord-018265-twp33bb6	587	32	antigens	antigen	NNS
cord-018265-twp33bb6	587	33	Delayed	delay	VBN
cord-018265-twp33bb6	587	34	and	and	CC
cord-018265-twp33bb6	587	35	deficient	deficient	JJ
cord-018265-twp33bb6	587	36	establishment	establishment	NN
cord-018265-twp33bb6	587	37	of	of	IN
cord-018265-twp33bb6	587	38	the	the	DT
cord-018265-twp33bb6	587	39	long	long	JJ
cord-018265-twp33bb6	587	40	-	-	HYPH
cord-018265-twp33bb6	587	41	term	term	NN
cord-018265-twp33bb6	587	42	bone	bone	NN
cord-018265-twp33bb6	587	43	marrow	marrow	NN
cord-018265-twp33bb6	587	44	plasma	plasma	NN
cord-018265-twp33bb6	587	45	cell	cell	NN
cord-018265-twp33bb6	587	46	pool	pool	NN
cord-018265-twp33bb6	587	47	during	during	IN
cord-018265-twp33bb6	587	48	early	early	JJ
cord-018265-twp33bb6	587	49	life	life	NN
cord-018265-twp33bb6	587	50	Influence	influence	NN
cord-018265-twp33bb6	587	51	of	of	IN
cord-018265-twp33bb6	587	52	Mycobacterium	Mycobacterium	NNP
cord-018265-twp33bb6	587	53	bovis	bovis	NN
cord-018265-twp33bb6	587	54	bacillus	bacillus	NN
cord-018265-twp33bb6	587	55	Calmette	Calmette	NNP
cord-018265-twp33bb6	587	56	-	-	HYPH
cord-018265-twp33bb6	587	57	Guerin	Guerin	NNP
cord-018265-twp33bb6	587	58	on	on	IN
cord-018265-twp33bb6	587	59	antibody	antibody	NN
cord-018265-twp33bb6	587	60	and	and	CC
cord-018265-twp33bb6	587	61	cytokine	cytokine	NN
cord-018265-twp33bb6	587	62	responses	response	NNS
cord-018265-twp33bb6	587	63	to	to	IN
cord-018265-twp33bb6	587	64	human	human	JJ
cord-018265-twp33bb6	587	65	neonatal	neonatal	JJ
cord-018265-twp33bb6	587	66	vaccination	vaccination	NN
cord-018265-twp33bb6	587	67	Transfer	transfer	NN
cord-018265-twp33bb6	587	68	of	of	IN
cord-018265-twp33bb6	587	69	antibody	antibody	NN
cord-018265-twp33bb6	587	70	via	via	IN
cord-018265-twp33bb6	587	71	mother	mother	NN
cord-018265-twp33bb6	587	72	's	's	POS
cord-018265-twp33bb6	587	73	milk	milk	NN
cord-018265-twp33bb6	587	74	Maternal	maternal	JJ
cord-018265-twp33bb6	587	75	immunization	immunization	NN
cord-018265-twp33bb6	587	76	with	with	IN
cord-018265-twp33bb6	587	77	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	587	78	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	587	79	vaccine	vaccine	NN
cord-018265-twp33bb6	587	80	in	in	IN
cord-018265-twp33bb6	587	81	the	the	DT
cord-018265-twp33bb6	587	82	Philippines	Philippines	NNP
cord-018265-twp33bb6	587	83	Pneumococcal	Pneumococcal	NNP
cord-018265-twp33bb6	587	84	conjugate	conjugate	NN
cord-018265-twp33bb6	587	85	vaccines	vaccine	NNS
cord-018265-twp33bb6	587	86	as	as	IN
cord-018265-twp33bb6	587	87	maternal	maternal	JJ
cord-018265-twp33bb6	587	88	and	and	CC
cord-018265-twp33bb6	587	89	infant	infant	NN
cord-018265-twp33bb6	587	90	immunogens	immunogen	NNS
cord-018265-twp33bb6	587	91	:	:	:
cord-018265-twp33bb6	587	92	challenges	challenge	NNS
cord-018265-twp33bb6	587	93	of	of	IN
cord-018265-twp33bb6	587	94	maternal	maternal	JJ
cord-018265-twp33bb6	587	95	recruitment	recruitment	NN
cord-018265-twp33bb6	587	96	The	the	DT
cord-018265-twp33bb6	587	97	protective	protective	JJ
cord-018265-twp33bb6	587	98	efficacy	efficacy	NN
cord-018265-twp33bb6	587	99	of	of	IN
cord-018265-twp33bb6	587	100	polyvalent	polyvalent	JJ
cord-018265-twp33bb6	587	101	pneumococcal	pneumococcal	JJ
cord-018265-twp33bb6	587	102	polysaccharide	polysaccharide	NN
cord-018265-twp33bb6	587	103	vaccine	vaccine	NN
cord-018265-twp33bb6	587	104	Booster	booster	NN
cord-018265-twp33bb6	587	105	effect	effect	NN
cord-018265-twp33bb6	587	106	of	of	IN
cord-018265-twp33bb6	587	107	low	low	JJ
cord-018265-twp33bb6	587	108	doses	dose	NNS
cord-018265-twp33bb6	587	109	of	of	IN
cord-018265-twp33bb6	587	110	tetanus	tetanus	NN
cord-018265-twp33bb6	587	111	toxoid	toxoid	NN
cord-018265-twp33bb6	587	112	in	in	IN
cord-018265-twp33bb6	587	113	elderly	elderly	JJ
cord-018265-twp33bb6	587	114	vaccinees	vaccinee	NNS
cord-018265-twp33bb6	587	115	Vaccine	vaccine	NN
cord-018265-twp33bb6	587	116	-	-	HYPH
cord-018265-twp33bb6	587	117	induced	induce	VBN
cord-018265-twp33bb6	587	118	antibodies	antibody	NNS
cord-018265-twp33bb6	587	119	to	to	IN
cord-018265-twp33bb6	587	120	heterologous	heterologous	NNP
cord-018265-twp33bb6	587	121	influenza	influenza	NN
cord-018265-twp33bb6	587	122	A	a	DT
cord-018265-twp33bb6	587	123	H1N1	H1N1	NNP
cord-018265-twp33bb6	587	124	viruses	virus	NNS
cord-018265-twp33bb6	587	125	:	:	:
cord-018265-twp33bb6	587	126	effects	effect	NNS
cord-018265-twp33bb6	587	127	of	of	IN
cord-018265-twp33bb6	587	128	aging	age	VBG
cord-018265-twp33bb6	587	129	and	and	CC
cord-018265-twp33bb6	587	130	"	"	``
cord-018265-twp33bb6	587	131	original	original	JJ
cord-018265-twp33bb6	587	132	antigenic	antigenic	JJ
cord-018265-twp33bb6	587	133	sin	sin	NN
cord-018265-twp33bb6	587	134	Variable	variable	JJ
cord-018265-twp33bb6	587	135	efficacy	efficacy	NN
cord-018265-twp33bb6	587	136	of	of	IN
cord-018265-twp33bb6	587	137	repeated	repeat	VBN
cord-018265-twp33bb6	587	138	annual	annual	JJ
cord-018265-twp33bb6	587	139	influenza	influenza	NN
cord-018265-twp33bb6	587	140	vaccination	vaccination	NN
cord-018265-twp33bb6	587	141	Annual	annual	JJ
cord-018265-twp33bb6	587	142	revaccination	revaccination	NN
cord-018265-twp33bb6	587	143	against	against	IN
cord-018265-twp33bb6	587	144	influenza	influenza	NN
cord-018265-twp33bb6	587	145	and	and	CC
cord-018265-twp33bb6	587	146	mortality	mortality	NN
cord-018265-twp33bb6	587	147	risk	risk	NN
cord-018265-twp33bb6	587	148	in	in	IN
cord-018265-twp33bb6	587	149	community	community	NN
cord-018265-twp33bb6	587	150	-	-	HYPH
cord-018265-twp33bb6	587	151	dwelling	dwell	VBG
cord-018265-twp33bb6	587	152	elderly	elderly	JJ
cord-018265-twp33bb6	587	153	persons	person	NNS
cord-018265-twp33bb6	587	154	Immunoinformatics	Immunoinformatics	NNP
cord-018265-twp33bb6	587	155	:	:	:
cord-018265-twp33bb6	587	156	bioinformatic	bioinformatic	JJ
cord-018265-twp33bb6	587	157	strategies	strategy	NNS
cord-018265-twp33bb6	587	158	for	for	IN
cord-018265-twp33bb6	587	159	better	well	JJR
cord-018265-twp33bb6	587	160	understanding	understanding	NN
cord-018265-twp33bb6	587	161	of	of	IN
cord-018265-twp33bb6	587	162	immune	immune	JJ
cord-018265-twp33bb6	587	163	function	function	NN
cord-018265-twp33bb6	587	164	.	.	.
cord-018265-twp33bb6	588	1	Introduction	introduction	NN
cord-018265-twp33bb6	588	2	SYFPEITHI	SYFPEITHI	NNP
cord-018265-twp33bb6	588	3	:	:	:
cord-018265-twp33bb6	588	4	database	database	NN
cord-018265-twp33bb6	588	5	for	for	IN
cord-018265-twp33bb6	588	6	MHC	MHC	NNP
cord-018265-twp33bb6	588	7	ligands	ligand	NNS
cord-018265-twp33bb6	588	8	and	and	CC
cord-018265-twp33bb6	588	9	peptide	peptide	NN
cord-018265-twp33bb6	588	10	motifs	motif	NNS
cord-018265-twp33bb6	589	1	PAProC	PAProC	NNP
cord-018265-twp33bb6	589	2	:	:	:
cord-018265-twp33bb6	589	3	a	a	DT
cord-018265-twp33bb6	589	4	prediction	prediction	NN
cord-018265-twp33bb6	589	5	algorithm	algorithm	NN
cord-018265-twp33bb6	589	6	for	for	IN
cord-018265-twp33bb6	589	7	proteasomal	proteasomal	JJ
cord-018265-twp33bb6	589	8	cleavages	cleavage	NNS
cord-018265-twp33bb6	589	9	available	available	JJ
cord-018265-twp33bb6	589	10	on	on	IN
cord-018265-twp33bb6	589	11	the	the	DT
cord-018265-twp33bb6	589	12	WWW	www	NN
cord-018265-twp33bb6	590	1	This	this	DT
cord-018265-twp33bb6	590	2	work	work	NN
cord-018265-twp33bb6	590	3	was	be	VBD
cord-018265-twp33bb6	590	4	supported	support	VBN
cord-018265-twp33bb6	590	5	in	in	IN
cord-018265-twp33bb6	590	6	part	part	NN
cord-018265-twp33bb6	590	7	by	by	IN
cord-018265-twp33bb6	590	8	grants	grant	NNS
cord-018265-twp33bb6	590	9	from	from	IN
cord-018265-twp33bb6	590	10	the	the	DT
cord-018265-twp33bb6	590	11	DFG	DFG	NNP
cord-018265-twp33bb6	590	12	(	(	-LRB-
cord-018265-twp33bb6	590	13	GU482/2	gu482/2	NN
cord-018265-twp33bb6	590	14	-	-	HYPH
cord-018265-twp33bb6	590	15	3	3	CD
cord-018265-twp33bb6	590	16	)	)	-RRB-
cord-018265-twp33bb6	590	17	and	and	CC
cord-018265-twp33bb6	590	18	the	the	DT
cord-018265-twp33bb6	590	19	BMBF	BMBF	NNS
cord-018265-twp33bb6	590	20	(	(	-LRB-
cord-018265-twp33bb6	590	21	"	"	``
cord-018265-twp33bb6	590	22	PathoGenoMik	pathogenomik	NN
cord-018265-twp33bb6	590	23	"	"	''
cord-018265-twp33bb6	591	1	-Competence	-Competence	NNP
cord-018265-twp33bb6	591	2	Center	Center	NNP
cord-018265-twp33bb6	591	3	for	for	IN
cord-018265-twp33bb6	591	4	Genome	Genome	NNP
cord-018265-twp33bb6	591	5	Research	Research	NNP
cord-018265-twp33bb6	591	6	of	of	IN
cord-018265-twp33bb6	591	7	Pathogenic	Pathogenic	NNP
cord-018265-twp33bb6	591	8	Bacteria	Bacteria	NNPS
cord-018265-twp33bb6	591	9	"	"	``
cord-018265-twp33bb6	591	10	Pathogenomik	Pathogenomik	NNP
cord-018265-twp33bb6	591	11	"	"	''
cord-018265-twp33bb6	591	12	,	,	,
cord-018265-twp33bb6	591	13	031U213B	031u213b	CD
cord-018265-twp33bb6	591	14	)	)	-RRB-
cord-018265-twp33bb6	591	15	to	to	IN
cord-018265-twp33bb6	591	16	CAG	CAG	NNP
cord-018265-twp33bb6	591	17	.	.	.
cord-018265-twp33bb6	592	1	We	-PRON-	PRP
cord-018265-twp33bb6	592	2	are	be	VBP
cord-018265-twp33bb6	592	3	particularly	particularly	RB
cord-018265-twp33bb6	592	4	grateful	grateful	JJ
cord-018265-twp33bb6	592	5	to	to	IN
cord-018265-twp33bb6	592	6	D.	D.	NNP
cord-018265-twp33bb6	592	7	Felnerova	Felnerova	NNP
cord-018265-twp33bb6	592	8	from	from	IN
cord-018265-twp33bb6	592	9	Etna	Etna	NNP
cord-018265-twp33bb6	592	10	Biotech	Biotech	NNP
cord-018265-twp33bb6	592	11	,	,	,
cord-018265-twp33bb6	592	12	who	who	WP
cord-018265-twp33bb6	592	13	provided	provide	VBD
cord-018265-twp33bb6	592	14	us	-PRON-	PRP
cord-018265-twp33bb6	592	15	with	with	IN
cord-018265-twp33bb6	592	16	a	a	DT
cord-018265-twp33bb6	592	17	micrograph	micrograph	NN
cord-018265-twp33bb6	592	18	from	from	IN
cord-018265-twp33bb6	592	19	a	a	DT
cord-018265-twp33bb6	592	20	transmission	transmission	NN
cord-018265-twp33bb6	592	21	electron	electron	NN
cord-018265-twp33bb6	592	22	microscopy	microscopy	NN
cord-018265-twp33bb6	592	23	of	of	IN
cord-018265-twp33bb6	592	24	a	a	DT
cord-018265-twp33bb6	592	25	virosome	virosome	NN
cord-018265-twp33bb6	592	26	,	,	,
cord-018265-twp33bb6	592	27	and	and	CC
cord-018265-twp33bb6	592	28	to	to	IN
cord-018265-twp33bb6	592	29	M.	M.	NNP
cord-018265-twp33bb6	592	30	Höfle	Höfle	NNP
cord-018265-twp33bb6	592	31	for	for	IN
cord-018265-twp33bb6	592	32	critical	critical	JJ
cord-018265-twp33bb6	592	33	reading	reading	NN
cord-018265-twp33bb6	592	34	of	of	IN
cord-018265-twp33bb6	592	35	the	the	DT
cord-018265-twp33bb6	592	36	manuscript	manuscript	NN
cord-018265-twp33bb6	592	37	.	.	.