id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320431-0877trhh	Frey, Andreas	More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis	2020-04-28		.txt	text/plain	15225	762	40	In case of asthma, all these functions are impaired by the already existing allergic immune response that per se weakens the barrier integrity and self-cleaning abilities of the airway epithelium making it more vulnerable to penetration of allergens as well as of infection by bacteria and viruses. Besides this innate "rapid response team, " the polarized epithelium of the human airways is also able to transport and apically release immunoglobulins that carry a J-chain (joining chain) by using its poly Ig receptor (pIgR) (145) (146) (147) that is expressed by all non-stratified epithelial cells (Figure 2) . After contact for example with HDM extracts, representing a major source of asthma associated allergens, TLR4 dependent activation of NFκB and protease induced injuries in airway epithelial cells lead to secretion of chemokines and cytokines like thymic stromal lymphopoietin (TSLP), GM-CSF, IL-25, and IL-33 (211) (212) (213) (214) (215) .	./cache/cord-320431-0877trhh.txt	./txt/cord-320431-0877trhh.txt