id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303674-0xo2fiop	Criscuolo, E.	Alternative Methods of Vaccine Delivery: An Overview of Edible and Intradermal Vaccines	2019-03-04		.txt	text/plain	7451	359	32	In particular, novel strategies based on edible or intradermal vaccine formulations have been demonstrated to trigger both a systemic and mucosal immune response. In this review, we discuss current advances and advantages of edible systems based on plants, algae, yeast, insect cells, and lactic acid bacteria and of the intradermal immunization route. Subsequently, the antigen(s) can be incorporated into different edible systems, as plants, algae, insects, or yeasts, or used for intradermal formulations to induce a mucosal protective response. Remarkably, some preclinical studies based on orally administrated Saccharomyces cerevisiae and developed for different infectious agents, such as HPV and Actinobacillus pleuropneumoniae, showed that this delivery system is able to induce a protective mucosal and a systemic immune response [68] [69] [70] . Another vaccine delivery route capable of triggering both systemic and mucosal immunities is the intradermal route, in which the antigen is delivered through the skin using recently developed self-administrable devices.	./cache/cord-303674-0xo2fiop.txt	./txt/cord-303674-0xo2fiop.txt