id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292983-msuluuuu	Ballesteros-Briones, María Cristina	A new generation of vaccines based on alphavirus self-amplifying RNA	2020-09-06		.txt	text/plain	4942	277	47	In particular, self-amplifying RNA (saRNA) derived from alphavirus expression vectors has shown to be very efficient to induce humoral and cellular responses against many antigens in preclinical models, being superior to non-replicating mRNA and DNA. In particular, self-amplifying RNA (saRNA) derived from alphavirus expression vectors has shown to be very efficient to induce humoral and cellular responses against many antigens in preclinical models, being superior to non-replicating mRNA and DNA. This type of LNP-delivered saRNA vaccines, named SAM (for self-amplifying mRNA) platform, have shown great potential to generate immune responses against influenza virus [20] [21] [22] and Toxoplasma gondii [23] . Despite the fact that the ta-RNA system was able to induce good immune responses in vivo against influenza virus HA, it did not outperform vaccination with a single saRNA molecule expressing the same antigen.	./cache/cord-292983-msuluuuu.txt	./txt/cord-292983-msuluuuu.txt