id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289961-7q2wkwrf	Chattopadhyay, Saborni	Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation	2017-06-09		.txt	text/plain	10531	581	32	Exploiting the same transport mechanisms aimed at detaining viruses, nanoparticle vaccines can effectively target immune cells in lymph nodes, delivering antigens or adjuvants following administration in peripheral tissues [13, 141, 142] (Fig. 3A) . Given the privilege of nanocarriers in lymphatic transport, nanoparticles have been shown to enhance the delivery of target antigens to lymph nodes and resident immune cells for processing and immune activation. In their animal study, strong anti-ovalbumin humoral response was observed [13] , highlighting the benefit of nanoparticle-mediated lymph node delivery on enhancing antigen processing. These virus-like particles showed high immunogenicity in both murine and avian models and enhanced anti-viral IgA and IgG titers and cellular immune responses in comparison to free protein antigens and a commercial WIV vaccine [155] . Not only can nanoparticle vaccines enhance humoral responses against target antigens, they have been shown to promote cell-based immunity as well as immunological memory.	./cache/cord-289961-7q2wkwrf.txt	./txt/cord-289961-7q2wkwrf.txt