id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288868-qfdxri93	Wack, Andreas	Vaccinology at the beginning of the 21st century	2005-06-13		.txt	text/plain	5082	224	43	Thus, the use of reverse genetics enables rapid production of a reference vaccine virus in response to the emergence of a new influenza variant [15 ,16] . Activation of DCs increases their ability to process and present antigen and to attract and activate T cells through cytokine secretion; consequently, several cytokines are 414 Host-pathogen interactions Table 1 Human TLR agonists used as adjuvants in vaccine formulations in clinical trials or licensed vaccines a . When viral vehicles (vaccinia or adenovirus) were compared with loaded DCs in terms of their ability to overcome established tolerance and induce immune responses in a transgenic mouse model, the viral formulations were able to do so, whereas DCs required repeated administration of TLR agonists or irrelevant virus, or removal of suppressive CD4 + CD25 + Treg cells [54 ] . A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease	./cache/cord-288868-qfdxri93.txt	./txt/cord-288868-qfdxri93.txt