id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-271250-ywb26cq6	Sarkar, Indranil	Selection of adjuvants for vaccines targeting specific pathogens	2019-04-22		.txt	text/plain	11394	542	39	In-depth understanding of the role of adjuvants in activating the innate immune system, combined with systems vaccinology approaches, have led to the development of next-generation, novel adjuvants that can be used in vaccines against challenging pathogens and in specific target populations. Intact MyD88 signaling in each of the three types of APCs (DCs, macrophages and B cells) is essential for robust activity of TLR ligand-based vaccine adjuvants (PorB, a TLR2 ligand and CpG, a TLR9 ligand) such as induction of in vivo cytokine responses, germinal center (GC) formation and antibody production [49] . A combination adjuvant consisting of poly(I:C), a host defense peptide and PCEP when delivered intranasally transiently induces production of chemokines and cytokines in murine respiratory tissues, which promotes infiltration and activation of DCs, macrophages, and neutrophils to generate improved mucosal and systemic immune responses [55] .	./cache/cord-271250-ywb26cq6.txt	./txt/cord-271250-ywb26cq6.txt