id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252568-b8sbvy0g	Marques Neto, Lázaro Moreira	Role of Metallic Nanoparticles in Vaccinology: Implications for Infectious Disease Vaccine Development	2017-03-08		.txt	text/plain	5317	260	39	There is evidence that these particles display adjuvant characteristics, promoting cell recruitment, antigen-presenting cell activation, cytokine production, and inducing a humoral immune response. However, many NPs have been shown to stimulate immune responses, including cell recruitment, activation of antigen (Ag)-presenting cells (APCs), and induction of cytokine and chemokine release. Among the vaccines targeting extracellular bacteria and toxin, two were formulated with lipopolysaccharide (LPS) in glycopeptide Ag. The use of glycoantigen and LPS can trigger an intense response through TLR4 and B cell receptor activation; the presence of gold NPs (AuNPs) may have minimal influence on this response. To understand the possible uses of MeNPs as platforms for vaccines against infectious diseases, analysis is needed of the impact of different physicochemical characteristics of NPs on the innate immune response (Figure 1) .	./cache/cord-252568-b8sbvy0g.txt	./txt/cord-252568-b8sbvy0g.txt