id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-126015-zc7u3g34	Krieger, Elizabeth	Immunological determinants of clinical outcomes in COVID-19: A quantitative perspective	2020-05-13		.txt	text/plain	6421	348	42	To better understand what impact these genetic variants in immune response genes may have in the differences observed in the immune response to SARS-CoV-2, a quantitative analysis of a dynamical systems model that considers both, the magnitude of viral growth, and the subsequent innate and adaptive response required to achieve control of infection is considered. To better understand what impact these genetic variants in immune response genes may have in the differences observed in the immune response to SARS-CoV-2, a quantitative analysis of a dynamical systems model that considers both, the magnitude of viral growth, and the subsequent innate and adaptive response required to achieve control of infection is considered. The HLA genes exhibit extreme allelic polymorphisms and present viral peptides on host HLA molecules to T cells to trigger an adaptive immune response. A quantitative approach relating differences in cytokine levels and polymorphisms in the immune response pathways may help identify patients at risk of severe disease.	./cache/cord-126015-zc7u3g34.txt	./txt/cord-126015-zc7u3g34.txt