id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-032600-lldbjm77	Soni, Dheeraj	The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems	2020-09-14		.txt	text/plain	6655	388	32	2 Second-generation efforts employed more characterized materials, such as the biodegradable synthetic polymer poly (D,L-lactic-co-glycolic acid) (PLGA), which is a widely investigated nanoparticle adjuvant for controlled and effective delivery of vaccine antigens, including synthetic peptides. 32 Thus, pathogen-mimicking nanoparticles can be engineered to enhance the immune response by controlling when and where vaccine components are delivered intracellularly to APCs. 15 A plethora of particulate delivery systems for immunoengineering have been developed, which are summarized further in this review. Recently, we have combined such engineering and rational vaccine design approaches to develop a nanoparticle-based adjuvant and antigen-delivery system designed to be active in human newborns and infants. Furthermore, such formulations hold substantial potential for early life immunization by serving as a dual antigen/adjuvant delivery system that mimics the enhanced neonatal innate and adaptive immune responses elicited by the live Bacille Calmette-Guerin (BCG) vaccine.	./cache/cord-032600-lldbjm77.txt	./txt/cord-032600-lldbjm77.txt